Raras
Buscar doenças, sintomas, genes...
Kuru
ORPHA:454745CID-10 · A81.8CID-11 · 8E01.1DOENÇA RARA

Doença de príon encontrada exclusivamente entre os nativos do grupo linguístico Fore das terras altas da Nova Guiné. A doença é restrita principalmente a mulheres adultas e crianças de ambos os sexos. É marcada pelo início subagudo de tremor e ataxia seguido de fraqueza motora e incontinência. A morte ocorre dentro de 3-6 meses após o início da doença. A condição está associada ao canibalismo ritual e tornou-se rara desde que esta prática foi descontinuada. As características patológicas incluem perda não inflamatória de neurônios que é mais proeminente no cerebelo, proliferação glial e placas amilóides. (De Adams et al., Princípios de Neurologia, 6ª ed, p773)

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Introdução

O que você precisa saber de cara

📋

Doença de príon encontrada exclusivamente entre os nativos do grupo linguístico Fore das terras altas da Nova Guiné. A doença é restrita principalmente a mulheres adultas e crianças de ambos os sexos. É marcada pelo início subagudo de tremor e ataxia seguido de fraqueza motora e incontinência. A morte ocorre dentro de 3-6 meses após o início da doença. A condição está associada ao canibalismo ritual e tornou-se rara desde que esta prática foi descontinuada. As características patológicas incluem perda não inflamatória de neurônios que é mais proeminente no cerebelo, proliferação glial e placas amilóides. (De Adams et al., Princípios de Neurologia, 6ª ed, p773)

Publicações científicas
727 artigos
Último publicado: 2026 Apr

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Casos conhecidos
2.700
pacientes catalogados
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: A81.8
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico727PubMed
Últimos 10 anos200publicações
Pico202576 papers
Linha do tempo
2026Hoje · 2026🧪 2022Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

1 gene identificado com associação a esta condição. Padrão de herança: Multigenic/multifactorial, Not applicable.

PRNPMajor prion proteinMajor susceptibility factor inTolerante
FUNÇÃO

Its primary physiological function is unclear. May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May promote myelin homeostasis through acting as an agonist for ADGRG6 receptor. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also

LOCALIZAÇÃO

Cell membraneGolgi apparatus

VIAS BIOLÓGICAS (1)
NCAM1 interactions
EXPRESSÃO TECIDUAL(Ubíquo)
Cérebro - Hemisfério cerebelar
529.6 TPM
Brain Frontal Cortex BA9
405.5 TPM
Cerebelo
382.9 TPM
Cólon sigmoide
312.1 TPM
Córtex cerebral
265.3 TPM
OUTRAS DOENÇAS (9)
Gerstmann-Straussler-Scheinker syndromeHuntington disease-like 1fatal familial insomniaspongiform encephalopathy with neuropsychiatric features
HGNC:9449UniProt:P04156

Variantes genéticas (ClinVar)

79 variantes patogênicas registradas no ClinVar.

🧬 PRNP: NM_000311.5(PRNP):c.229C>T (p.His77Tyr) ()
🧬 PRNP: NM_000311.5(PRNP):c.325A>T (p.Met109Leu) ()
🧬 PRNP: NM_000311.5(PRNP):c.284C>A (p.Thr95Asn) ()
🧬 PRNP: NM_000311.5(PRNP):c.304C>T (p.Pro102Ser) ()
🧬 PRNP: NM_000311.5(PRNP):c.88G>A (p.Gly30Arg) ()
Ver todas no ClinVar

Classificação de variantes (ClinVar)

Distribuição de 11 variantes classificadas pelo ClinVar.

3
3
5
Patogênica (27.3%)
VUS (27.3%)
Benigna (45.5%)
VARIANTES MAIS SIGNIFICATIVAS
PRNP: NM_000311.5(PRNP):c.538G>A (p.Val180Ile) [Conflicting classifications of pathogenicity]
PRNP: NM_000311.5(PRNP):c.628G>A (p.Val210Ile) [Pathogenic/Likely pathogenic/Pathogenic, low penetrance]
PRNP: NM_000311.5(PRNP):c.598G>A (p.Glu200Lys) [Pathogenic]
PRNP: NM_000311.5(PRNP):c.498G>A (p.Met166Ile) [Uncertain significance]
PRNP: NM_000311.5(PRNP):c.*115G>A [Uncertain significance]

Vias biológicas (Reactome)

2 vias biológicas associadas aos genes desta condição.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Kuru

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

Nenhum ensaio clínico registrado para esta condição.

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Publicações mais relevantes

Timeline de publicações
109 papers (10 anos)
#1

When I use a word . . . Medical anniversaries in 2026.

BMJ (Clinical research ed.)2026 Jan 09

My list of medically related anniversaries for 2026 (events in years ending '26 and'76) includes:• Births: Abū al-Walīd Muḥammad ibn Aḥmad ibn Rushd, the physician better known as Averroes (1126); the Flemish botanist Charles de L'Ecluse (Carolus Clusius) (1576); Amadeo Avogadro, Italian physicist (1776); Johann Spurzheim, German physician (1776); George Birkbeck, English physician (1776).• Deaths: Francis Bacon (1626); Jean Anthelme Brillat-Savarin, French lawyer and gastronome (1826); Friedrich Wilhelm Weiß, German physician and composer (1826); René Laënnec, French physician (1826); Philippe Pinel, French physician (1826); Walter Channing, American physician (1876); Victor Babeș, Romanian physician and bacteriologist (1926); William Bateson, English biologist (1926); Emile Coué, French pharmacist and psychologist (1926); Camillo Golgi, Italian anatomist (1926); Emil Kraepelin, German psychiatrist (1926); Einar Aaser, Norwegian physician (1976); Andrew Arthur Abbie, Australian anatomist and anthropologist (1976); Jacques Monod, molecular biologist (1976); George Whipple, American physician (1976); Alexander S Wiener, American physician (1976).• Biomedical texts published: Observationes medicae circa morborum acutorum historiam et curationem by Thomas Sydenham (1676); A Comment on Forty two Histories Discribed [sic] by Hippocrates in the First and Third Books of his Epidemics by John Floyer (1726); The botanical arrangement of all the vegetables naturally growing in Great Britain by William Withering (1776); De generis humani varietate nativa by Johann Friedrich Blumenbach (1776); L'uomo delinquente (Criminal Man) by Cesare Lombroso (1876); Geographical distribution of animals by Alfred Wallace (1876); The theory of the gene by Thomas Hunt Morgan (1926).• Clinical therapies introduced: George Richards Minot and William Parry Murphy (treatment of pernicious anaemia with liver, 1926).• Biochemical and bacteriological observations: Karl Wilhelm Scheele (uric acid in kidney stones, 1776); Otto Unverborden (discovery of aniline, 1826); Robert Koch (the anthrax bacillus, 1876); James Batcheller Sumner (crystallisation of jackbean urease, 1926).• Establishment of the Edinburgh Medical School (1726) and of The Body Shop (Anita Roddick, 1976).• Epidemics of typhus in Spain (1576) and Ebola virus infection in Yambuku, Zaire (1976).• Nobel prizes for physiology or medicine awarded to Baruch Samuel Blumberg for identifying Australia antigen as an indicator in the blood of hepatitis B and to Daniel Carleton Gajdusek for his work on the origin and spread of infectious diseases, particularly slow virus infections and specifically kuru (both 1926), and to Johannes Andreas Grib Fibiger for discovering the Spiroptera carcinoma (1976).

#2

A Longitudinal Study on Symptom Severity in Early Childhood of Bilingual and Monolingual Children With Autism Spectrum Disorder.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience2026 Feb

In increasingly globalized and multilingual societies, a key question for individuals with autism spectrum disorder (ASD) is how bilingual exposure influences their linguistic, cognitive, and social development. This study aimed to investigate the potential impact of a bilingual home environment on the severity and progression of ASD symptoms in children. The study was conducted with 3-year follow-up results of a total of 69 children, 34 with bilingual home situations (BHSs) and 35 with monolingual home situations (MHSs). The Childhood Autism Rating Scale (CARS) was applied to assess the severity of the participants' ASD symptoms. Neurodevelopmental evaluations were performed using the Denver Developmental Screening Test II (DDST-II). No significant differences were determined between the MHS and BHS groups in terms of developmental quotient total (DQt) baseline (p = 0.618), DQt follow-up (p = 0.288), or CARS baseline (p = 0.970) scores. However, CARS follow-up scores, indicative of greater symptom severity, were significantly higher in the BHS group (p = 0.030). While the MHS group showed a notable decrease in CARS scores, the BHS group's scores tended to persist, with the decrease in CARS scores being significantly lower than that observed in the MHS group (p < 0.001). These findings suggest that children with ASD raised in bilingual home environments may exhibit comparatively less improvement in symptom severity over time. The influence of bilingualism on ASD may involve a range of complex linguistic, cognitive, and social factors. Future research should explore these variables in larger, more detailed studies.

#3

Cross-education after forearm fracture: a randomised controlled trial.

Irish journal of medical science2026 Feb

This study aimed to examine whether isokinetic exercises applied to the intact wrist could reduce muscle strength loss and prevent the development of Complex Regional Pain Syndrome (CRPS) type I in adults with distal radius fractures. Forty-two patients with distal radius fractures were randomized into two groups: a Cross-Education (CE) group (n = 21) and a control group (n = 21). Both groups received a standard home exercise program. In addition, the CE group performed 12 supervised sessions of isokinetic wrist strengthening exercises on the non-fractured side during the immobilization period. After cast removal, isometric muscle strength of the fractured wrist was evaluated, and patients were monitored for the development of CRPS type I. The CE group showed significantly higher isometric muscle strength in wrist flexors and extensors compared with the control group (wrist flexors: d = 0.73, p = 0.024; wrist extensors: d = 0.87, p = 0.008). Furthermore, the incidence of CRPS type I was significantly lower in the CE group (p = 0.03). Cross-Education training applied during immobilization can prevent muscle weakness and decrease the risk of CRPS in fracture rehabilitation. These findings highlight CE as a safe and effective early intervention strategy that may enhance functional outcomes and reduce complications in patients with distal radius fractures.

#4

Response to Letter on "Hemostasis Time as a Criterion in Vital Pulpotomy: Methodological and Biological Considerations".

Medical principles and practice : international journal of the Kuwait University, Health Science Centre2026 Feb 20
#5

[Prion diseases : Creutzfeldt-Jakob and differential diagnoses].

Radiologie (Heidelberg, Germany)2026 Mar 09

Prions are unprecedented infectious pathogens that cause a group of rare and inevitably fatal neurodegenerative diseases, affecting approximately 1 person per 1 million inhabitants worldwide each year. These diseases include Creutzfeldt-Jakob disease (CJD), Gerstmann-Sträussler-Scheinker syndrome (GSS), kuru, fatal insomnia (FI) and variably protease-sensitive prionopathy (VPSPr), all of which involve a conformational change of normal cellular prion protein (PrPC) into abnormal scrapie prion protein (PrPSc) through a posttranslational process. This structural change is associated with profound alterations in the physicochemical properties of PrPC, making the molecule resistant to proteolysis. The conformational alteration of PrPC can occur either due to spontaneous conversion, dominant mutations in the prion protein gene (PRNP) which codes for PrPC or due to an infection with the pathogenic isoform PrPSc from exogenous sources. There is general consensus that PrPC serves as the substrate for the conversion to abnormal PrPSc. The latter multiplies exponentially and accumulates in the brain, forming deposits which are associated with the neurodegenerative changes. Although the understanding of the main causes of prion-induced neurodegeneration is still limited, the spread of PrPSc and neurotoxic signal transfer in the pathogenic process of prions appear to show an interaction. Prion diseases sometimes have long incubation times but also short clinical trajectories. Sporadic and genetic forms occur worldwide of which genetic forms are associated with mutations in PRNP. Zoonotic forms of prion diseases are also associated with bovine diseases. Substantial progress has been made in the diagnosis of these disorders and the diagnostics include magnetic resonance imaging (MRI) and laboratory investigations, particularly of the cerebrospinal fluid. Prionen sind beispiellose infektiöse Krankheitserreger, die eine Gruppe seltener und unweigerlich tödlicher neurodegenerativer Erkrankungen verursachen, die weltweit jährlich etwa 1 Person pro 1 Mio. Einwohner betreffen. Zu diesen Erkrankungen gehören die Creutzfeld-Jacob-Krankheit (CJK), Gerstmann-Sträussler-Scheinker-Syndrom (GSS), Kuru, fatale Schlaflosigkeit (FI) und variable Protease-sensitive Prionopathie (VPSPr), die alle eine konformationelle Veränderung des normalen zellulären Prionproteins (PrPC) in das abnormale Scrapie-Prionprotein (PrPSc) durch einen posttranslationalen Prozess beinhalten. Diese strukturelle Veränderung geht mit tiefgreifenden Veränderungen in den physikochemischen Eigenschaften von PrPC einher, wodurch das Molekül widerstandsfähig gegen Proteolyse wird. Die konformationelle Veränderung von PrPC kann entweder durch spontane Umwandlung, dominante Mutationen im Prionprotein(PRNP)-Gen, das für PrPC codiert, oder durch eine Infektion mit der pathogenen Isoform PrPsc aus exogenen Quellen entstehen. Es besteht allgemeine Einigkeit darüber, dass PrPC als Substrat für die Umwandlung zu abnormalem PrPSc dient. Letzteres vermehrt sich exponentiell und sammelt sich im Gehirn, wodurch Ablagerungen entstehen, die mit den neurodegenerativen Veränderungen verbunden sind. Obwohl das Verständnis der Hauptursachen der prioninduzierten Neurodegeneration noch begrenzt ist, scheint zwischen der Ausbreitung von PrPSc und neurotoxischer Signalübertragung im pathogenen Prozess der Prionen eine Wechselwirkung zu bestehen. Prionenerkrankungen weisen z. T. lange Inkubationszeiten auf und andererseits kurze klinische Verläufe. Weltweit kommen sporadische und genetische Formen vor, von denen genetische Formen mit Mutationen in PRNP assoziiert sind. Zoonotische Formen von Prionenerkrankungen sind u. a. mit Rinderkrankheiten verbunden. Bei der Diagnose dieser Störungen wurden erhebliche Fortschritte erzielt, die Diagnose umfassen Magnetresonanztomographie (MRT) und laborchemische Untersuchungen, insbesondere des Liquor cerebrospinalis.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC305 artigos no totalmostrando 193

2026

[Prion diseases : Creutzfeldt-Jakob and differential diagnoses].

Radiologie (Heidelberg, Germany)
2026

Lithic Miniaturization Provides a Signature of an MIS4-3 Southern Dispersal of Homo sapiens.

Evolutionary anthropology
2026

Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy.

bioRxiv : the preprint server for biology
2026

Pilot evaluation of transcutaneous vagus nerve stimulation in chronic tinnitus: clinical outcomes and DTI insights.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
2026

Medical Decision Making in Relative Risk Scenarios: Understanding the Challenges of Communicating Alternative Health.

Health communication
2026

Influence of Generalized Joint Hyperlaxity on Volar Plate Configuration and Its Interaction with the FDP Tendon in the Proximal Interphalangeal Joint: An MRI Study.

The British journal of radiology
2026

Aronia Melanocarpa as a Multifunctional Superberry: From Antioxidant Potential to Therapeutic and Nanotechnological Applications.

Current nutrition reports
2026

Assessing the predictive value of the American College of Surgeons National Surgical Quality Improvement Program surgical risk model in a high-volume gynecologic oncology center in Turkey: a retrospective cohort study.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
2026

[How can the suitability of a geriatric patient for uro-oncological treatment be determined?].

Urologie (Heidelberg, Germany)
2025

Coaching effectiveness in competitive youth contact sports and martial arts: athletes' and coaches' perceptions.

Frontiers in psychology
2026

One-hot news: drug synergy models shortcut molecular features.

Bioinformatics (Oxford, England)
2026

Nerve transfers and central nervous system control in brachial plexus and peripheral nerve injuries: toward a balanced reconstructive strategy.

The Journal of hand surgery, European volume
2026

When I use a word . . . Medical anniversaries in 2026.

BMJ (Clinical research ed.)
2026

Comparison of Side Effects Between 3-Monthly and 1-Monthly Paliperidone Palmitate Formulations in Patients With Schizophrenia.

Human psychopharmacology
2026

A Longitudinal Study on Symptom Severity in Early Childhood of Bilingual and Monolingual Children With Autism Spectrum Disorder.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
2025

Retrospective Multicenter Analysis of Malignant Struma Ovarii: Clinical Characteristics, Management, and Outcomes.

Journal of clinical medicine
2025

Evaluation of Preoperative Capnographic Parameters in Children with Suspected Foreign Body Aspiration.

Children (Basel, Switzerland)
2025

Cardiovascular disease knowledge, risk perception, and lifestyle behaviors among university students in North-Central Nigeria: a cross-sectional study.

BMC public health
2025

Some morphological characteristics, growth performance and survival rate in Gurcu goat kids.

Tropical animal health and production
2025

Effects of fixed orthodontic treatment on taste perception: a randomized controlled trial.

Clinical oral investigations
2026

Relationships Between Nerve Ultrasound Findings and Clinical, Genetic, Laboratory and Electrophysiological Findings in Patients With Chronic Idiopathic Axonal Polyneuropathy.

Muscle &amp; nerve
2025

Pilot In Vitro Study to Assess Cleaning Ability and Effects of Different Decontamination Methods on Implant Surfaces.

Journal of visualized experiments : JoVE
2026

Tideglusib-loaded chitosan-incorporated bacterial cellulose hydrogel for enhanced palatal wound healing.

International journal of biological macromolecules
2025

Nerve ultrasound, neuronopathy and cough predict sensory neuropathy patients with RFC1 expansions.

Brain communications
2025

Plasma Neurofilament Light Chain and Phosphorylated Tau Are Elevated in Myotonic Dystrophy Type 1.

Journal of clinical medicine
2025

Imaging-based characterization of tumoral heterogeneity for personalized cancer treatment.

Nuklearmedizin. Nuclear medicine
2025

The mycomembrane proteins PorH and ProtX are inserted at polar growth zones and linked to the cell wall.

bioRxiv : the preprint server for biology
2025

The Effects of Anxiety on Social Competence and Behavioural Adjustment in Preschoolers With Developmental Language Disorder.

International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience
2025

Nerve ultrasound abnormality in RFC1 positive isolated sensory neuropathy is milder than in the full RFC1 canvas phenotype.

Clinical neurophysiology practice
2026

Cross-education after forearm fracture: a randomised controlled trial.

Irish journal of medical science
2025

The Ameliorative Effects of Morin on Colistin-Induced Kidney Injury in Ovariectomized Rats: Reduces Oxidative Stress, Inflammation Damage, Apoptosis, and Autophagic Death.

Journal of biochemical and molecular toxicology
2025

Biochemical and Immunohistochemical Evaluation of the Effects of Zingerone Against Colistin-Induced Lung Injury in Ovariectomized Rats.

Journal of biochemical and molecular toxicology
2025

Postpartum macrominerals and trace elements dynamics in cows: A potential early indicator of endometritis?

Animal reproduction science
2025

First Report of RET Fusion-Positive Lung Adenocarcinoma With Miliary Intrapulmonary Metastases Responsive to Selpercatinib: A Case Report.

Clinical case reports
2025

Dosimetric feasibility of stereotactic arrhythmia radioablation for ventricular tachycardia in patients with a subcutaneous implantable cardioverter defibrillator.

Physics and imaging in radiation oncology
2025

Effects of platelet-rich plasma in experimental acute acoustic trauma.

Science progress
2025

Comparison of two different pilates exercise methods in individuals with Ankylosing Spondylitis: A randomized controlled study.

Journal of bodywork and movement therapies
2025

Efficacy and Mid-Term Outcomes of Paclitaxel-Coated Balloon (Optilume®) for Penile Strictures.

Journal of clinical medicine
2025

Comparison of CTA and DSA collateral scores in predicting clinical outcome in anterior circulation stroke patients receiving endovascular treatment: A retrospective observational study.

Medicine
2025

Biochemical responses in Salvia limbata CA Mey. towards mercury and lead induced in vitro oxidative stress.

Scientific reports
2025

MicroRNAs as prognostic and predictive biomarkers among chronic myeloid leukemia patients in Addis Ababa, Ethiopia.

Scientific reports
2025

Atomistic mechanisms of calcium permeation modulated by Q/R editing and selectivity filter mutations in GluA2 AMPA receptors.

Proceedings of the National Academy of Sciences of the United States of America
2025

Rethinking survey development in health research with AI-driven methodologies.

Frontiers in digital health
2025

Evaluation of minimum pinch force while holding in fibromyalgia patients.

Irish journal of medical science
2025

Radiomics Signature of Aging Myocardium in Cardiac Photon-Counting Computed Tomography.

Diagnostics (Basel, Switzerland)
2026

[Prophylaxis of recurrent urinary tract infections by nitroxoline-real-world data of the ProNitrox study].

Urologie (Heidelberg, Germany)
2025

Bread crust extract is a novel activator of aryl hydrocarbon receptor and modulator of NRF2 and NFκB in HepG2 and HCT 116 cells.

Current research in food science
2025

PHACE: Phylogeny-Aware Detection of Molecular Coevolution.

Molecular biology and evolution
2026

Vitamins K2 and D3 enhance guided bone regeneration in rat calvarial bone defects.

Journal of periodontology
2025

Spectral resolution and speech comprehension performance in noise in individuals with multiple sclerosis.

BMC neurology
2025

Prion-induced ferroptosis is facilitated by RAC3.

Nature communications
2026

Anatomical classification of septum pellucidum variations and analysis of the co-occurrence of the variations with psychiatric disorders.

The neuroradiology journal
2025

[Androgen deprivation therapy of prostate cancer from a geriatric perspective].

Zeitschrift fur Gerontologie und Geriatrie
2025

Immediate Pericardial Protamine Administration During Uncontrollable Acute Iatrogenic Hemorrhagic Cardiac Tamponade: A Safety and Feasibility Study.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
2025

The effect of simulation-based breast health education on breast cancer awareness and breast self-examination skills of Afghan refugee women: a randomized controlled trial.

BMC public health
2025

Family stress and resilience to earthquake-related economic hardship in Turkish families with preschool children.

Journal of family psychology : JFP : journal of the Division of Family Psychology of the American Psychological Association (Division 43)
2025

Post-Operative Pain and Its Relationship with Patient-Related Factors after Vital Pulpotomy in Teeth with Symptomatic Pulpitis: A Prospective Clinical Study.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre
2025

Prion diseases: Lessons from historical outbreaks and potential emerging ones.

Protein science : a publication of the Protein Society
2025

Assessment of the radiological health hazards around mine sites in Jos Area, Nigeria.

Environmental geochemistry and health
2025

Psychometric Properties of the Turkish Version of the Movement Imagery Questionnaire for Children.

Turkish archives of pediatrics
2025

Industrial noise: impacts on workers' health and performance below permissible limits.

BMC public health
2025

The Effect of Neutrophil-to-Lymphocyte Ratio on Prognosis in Malignant Ovarian Germ Cell Tumors.

Diagnostics (Basel, Switzerland)
2025

The Management of Ischemic Priapism Due to Sickle Cell Disease and Other Etiologies: Treatment Strategies and Indications for Penile Prosthesis Implantation in an Endemic Region.

Medicina (Kaunas, Lithuania)
2025

Off-label Use of the Optilume Drug-coated Balloon in the Treatment of Bladder Neck Stenosis and Vesicourethral Anastomosis Stenosis.

European urology open science
2025

Spinal segmental myoclonus following ultrasound-guided suprascapular nerve block: A case report.

Turkish journal of physical medicine and rehabilitation
2025

Thirteen-year-old Child Develops Squamous Cell Carcinoma Without Underlying Causes.

Plastic and reconstructive surgery. Global open
2025

The effects of systemic ozone application and hyperbaric oxygen therapy on avascular necrosis of the femoral head: An experimental study in the vascular deprivation of the rat femoral head model.

Joint diseases and related surgery
2025

Validity and Reliability of the Core Beliefs Questionnaire in a Sample of Individuals with Generalized Anxiety Disorder and Non-Clinical Samples.

Psychiatry and clinical psychopharmacology
2025

A prospective randomized clinical trial and an in vitro evaluation of the microtensile bond strength of a chlorhexidine-containing dentin bonding agent and a bulk fill composite material in primary teeth.

BMC oral health
2025

Usage of the Internet and Digital Health among Urological Patients: Findings from a Cross-Sectional Study.

Urologia internationalis
2025

Antidepressant-associated sexual dysfunction in outpatients.

BMC psychiatry
2025

Invalidity of Ikanecator Zoral & Lajbner, 2024 (Copepoda, Harpacticoida, Miraciidae) and comparison with Amphiascoides choi (Chullasorn, Anansatitporn, Kangtia, Klangsin & Jullawateelert, 2011).

Zootaxa
2025

Can Artificial Intelligence Language Models Effectively Address Dental Trauma Questions?

Dental traumatology : official publication of International Association for Dental Traumatology
2025

Biomechanical Comparison of Single- and Double-Twist Tension Band, Cancellous Screw, and Single-Screw Tension Band Models in Medial Malleolus Fractures.

Journal of the American Podiatric Medical Association
2025

Hydrogen-rich water consumption modifies the chemical, biochemical, nutritional, and bioactive properties of the goat's colostrum and mature milk.

Food chemistry
2025

Effects of Hydrogen-Rich Water on Growth, Redox Homeostasis and Hormonal, Histological and Immune Systems in Rats Exposed to High Cage Density Stress.

Veterinary medicine and science
2025

Changes in Doppler Ultrasonography and Echotexture Parameters in Cows During the Last 10 Days of Pregnancy.

Veterinary medicine and science
2025

Feasibility, Safety, and Patient Satisfaction of Transurethral Bladder Tumor Resection in an Outpatient Setting.

Cancer reports (Hoboken, N.J.)
2025

A humanized NOVA1 splicing factor alters mouse vocal communications.

Nature communications
2025

Coping skills and smartphone addiction in adolescents with ADHD: A predictive model and relationship.

Journal of child and adolescent mental health
2025

Electrocardiogram-gated cardiac computed tomography-based patient- and segment-specific cardiac motion estimation method in stereotactic arrhythmia radioablation for ventricular tachycardia.

Physics and imaging in radiation oncology
2025

Integrated site selection model for industrial areas: case study for İnegöl furniture industry.

Environmental science and pollution research international
2024

Sporadic Creutzfeldt-Jakob Disease: A Case Report and Literature Review.

Cureus
2024

Comparison of Bicortical Headless Cannulated Screw Fixations, Tension Band Fixations, and Kirschner Wire Fixations of a Jones Fracture: A Biomechanical Study.

Journal of the American Podiatric Medical Association
2024

The relationship between the functional status of the extremities and "core" stabilization in women with fibromyalgia.

Reumatologia
2025

The 2D:4D ratios in the mothers of children with attention deficit hyperactivity disorder.

Early human development
2025

An alternative for hysteroscopic myomectomy: Ultrasound-guided single-step myomectomy for submucous myoma uteri with ring forceps, a retrospective study.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2025

Feasibility of on-site CT-FFR analysis on cardiac photon-counting CT in evaluation of hemodynamically significant stenosis in comparison to invasive catheter angiography.

European journal of radiology
2025

Efficacy of tranilast in preventing exacerbating cardiac function and death from heart failure in muscular dystrophy patients with advanced-stage heart failure: a single-arm, open-label, multicenter study.

Orphanet journal of rare diseases
2024

Association of the immunogenicity of intramuscular SARS-CoV-2 mRNA vaccination with computed tomography muscle images in patients with muscular disorders.

Frontiers in immunology
2025

Evaluation of the bone regenerative effect of glycogen synthase kinase 3 antagonist Tideglusib carried by different scaffolds on rat calvarial defects.

International journal of biological macromolecules
2024

Short-Term Urinary Incontinence After Radical Prostatectomy Is Still Based on Patients' Age, Nerve-Sparing Approach, and Surgical-Experience, Despite the Higher-Use of Robotic Surgery in 2022 Compared to 2016 Real-World Results of a Large Rehabilitation Center in Germany.

Cancer reports (Hoboken, N.J.)
2024

Medical education videos - comparative analysis of sonography vs. clinical examination videos: user perception and educational value.

BMC medical education
2024

Consensus on transition care for juvenile idiopathic arthritis: a Delphi study with youth, caregivers, and health professionals.

Pediatric rheumatology online journal
2024

Physicochemical properties of stingless bees (Meliponula beccarii) honey in Dandi and Meta Robi districts of West Shewa zone, Ethiopia.

PloS one
2025

Unusual synchronous and metachronous association of hematologic neoplasms with gynecologic neoplasms: A case series and literature review.

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics
2024

Histopathological Comparison of Various Tongue Base Reduction Processes.

Nigerian journal of clinical practice
2025

Urinary titin reflects the severity of walking ability, muscle strength, and muscle and cardiac damage in patients with Becker muscular dystrophy.

Clinica chimica acta; international journal of clinical chemistry
2024

Dentinal tubule occlusion effects of dipotassium oxalate and diode laser combination: a single-blind in vitro study.

BMC oral health
2024

Evolutionary history of calcium-sensing receptors unveils hyper/hypocalcemia-causing mutations.

PLoS computational biology
2024

Comparison of diagnostic accuracy of radiomics parameter maps and standard reconstruction for the detection of liver lesions in computed tomography.

Frontiers in oncology
2024

Evaluation of the teratogenic effects of pregabalin usage during pregnancy: A multicenter case-control study.

Northern clinics of Istanbul
2024

CTG repeat length underlying cardiac events and sudden death in myotonic dystrophy type 1.

European heart journal open
2024

The Effect of Tideglusib Application on Type 1 and Type 3 Collagen Expressions by Human Dental-Pulp Derived Stem Cells: A Preliminary Study.

Nigerian journal of clinical practice
2025

A structural equation model of parenting and child's resilience after the earthquake in Türkiye.

Family process
2024

Exploring Alternative Health Facebook Groups in the COVID-19 Pandemic: An Automated Content Analysis Through Structural Topic Modeling.

Cyberpsychology, behavior and social networking
2024

Effect of birth type and sex on growth performance, wither height, humerus-radius bone dimensions, humerus-ulna growth plate width and selected hormone profile in growing Gurcu goat kids.

Veterinary medicine and science
2024

Evaluation of helical tomotherapy as an alternative for left-sided breast cancer patients not compliant with deep inspiration breath hold.

Technical innovations &amp; patient support in radiation oncology
2024

Rapid discovery and evolution of nanosensors containing fluorogenic amino acids.

Nature communications
2025

Virtual goniometric measurement of the forearm, wrist, and hand: A double-blind psychometric study of a digital goniometer.

Journal of hand therapy : official journal of the American Society of Hand Therapists
2024

Assessment of MMP levels in reversible and irreversible pulpitis and a randomized controlled trial comparing clinical success of two different calcium-silicate cements in pulpotomy treatment of primary molars with an 18-month follow-up.

BMC oral health
2024

An autopsy case of progressive supranuclear palsy with severe corticospinal tract degeneration.

Neuropathology : official journal of the Japanese Society of Neuropathology
2025

Theory of Mind Abilities May Predict Treatment Outcomes in Adolescents With Obsessive-Compulsive Disorder: A Follow-Up Study.

Early intervention in psychiatry
2024

The effect of the combined application of elicitors to Salvia virgata Jacq. under salinity stress on physiological and antioxidant defense.

BMC plant biology
2025

Assessing predictions on fitness effects of missense variants in HMBS in CAGI6.

Human genetics
2025

Phytochemical profile and antioxidant capacity of the endemic species Bellevalia sasonii Fidan.

Zeitschrift fur Naturforschung. C, Journal of biosciences
2026

Effects of high- versus low-intensity lipid-lowering treatment in patients undergoing serial coronary computed tomography angiography: results of the multi-center LOCATE study.

Clinical research in cardiology : official journal of the German Cardiac Society
2024

Structure, governance and delivery of specialist training programs in periodontology and implant dentistry.

Journal of clinical periodontology
2024

Effect of sainfoin (Onobrychis viciifolia Scop.) seed-based diet on rats: A comprehensive evaluation of hemogram, biochemistry, and histopathology.

Food science &amp; nutrition
2024

Prion diseases, always a threat?

Journal of the neurological sciences
2024

Poly (hydroxyethylmethacrylate-co-methacryloyl glutamic acid) nanocarrier system for controlled release of levothyroxine.

Journal of biomaterials science. Polymer edition
2024

The Role of Endometrial Sampling before Hysterectomy in Premenopausal Women with Abnormal Uterine Bleeding.

Journal of clinical medicine
2025

Template-independent enzymatic synthesis of RNA oligonucleotides.

Nature biotechnology
2024

Relationship Between Motion Sickness Susceptibility and Vestibular Test Results.

Medeniyet medical journal
2024

Updated global epidemiology atlas of human prion diseases.

Frontiers in public health
2024

PHACTboost: A Phylogeny-Aware Pathogenicity Predictor for Missense Mutations via Boosting.

Molecular biology and evolution
2024

Comparison of remineralization ability of tricalcium silicate and of glass ionomer cement on residual dentin: an in vitro study.

BMC oral health
2024

Loss-of-function polymorphisms in NQO1 are not associated with the development of subacute myelo-optico-neuropathy.

Molecular genetics &amp; genomic medicine
2024

Development of nanobiosensor for therapeutic drug monitoring in personalized cancer treatment approach.

Journal of biomaterials science. Polymer edition
2025

Islands and Neurology: An Exploration into a Unique Association.

The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
2024

Bone mineral density of the incus body and long process in patients with chronic otitis media and its relationship with functional outcome in type II tympanoplasty.

Acta oto-laryngologica
2024

Frequency of fibromyalgianess in patients with rheumatoid arthritis and ankylosing spondylitis: A multicenter study of Turkish League Against Rheumatism (TLAR) network.

Archives of rheumatology
2024

Determination of anti-Müllerian hormone levels in blood and urine in fertile cats.

Theriogenology
2022

From cell lines to cancer patients: personalized drug synergy prediction.

Bioinformatics (Oxford, England)
2024

Treatment of multiple adjacent gingival recessions using leucocyte- and platelet-rich fibrin with coronally advanced flap: a 12-month split-mouth controlled randomized clinical trial.

Clinical oral investigations
2024

Prion meeting 2023: implications of a growing field.

Prion
2024

The Association Between Physical Activity/Heart Rate Variability Data Obtained Using a Wearable Device and Timed Motor Functional Tests in Patients with Duchenne Muscular Dystrophy: A Pilot Study.

Journal of neuromuscular diseases
2024

Potential of photon counting computed tomography derived spectral reconstructions to reduce beam-hardening artifacts in chest CT.

European journal of radiology
2024

Facioscapulohumeral muscular dystrophy Health Index: Japanese translation and validation study.

Disability and rehabilitation
2024

Characteristics of patients with late recurrence endometrial cancer.

Journal of cancer research and therapeutics
2024

Investigation of the effects of different drugs on the prevention of intrapleural adhesion in a rat model.

Turk gogus kalp damar cerrahisi dergisi
2024

Viroids, Satellite RNAs and Prions: Folding of Nucleic Acids and Misfolding of Proteins.

Viruses
2024

Diagnostic and prognostic efficacy of optic nerve sheath diameter in patients with dysnatremia.

Medical ultrasonography
2024

Population structure and migration in the Eastern Highlands of Papua New Guinea, a region impacted by the kuru epidemic.

American journal of human genetics
2024

Hydrogen-rich water supplementation improves metabolic profile during peripartum period in Gurcu goats and enhances the health and survival of kids.

Research in veterinary science
2023

Prognostic value of lymph node features in patients diagnosed with stage IIIC endometrial adenocancer.

Journal of cancer research and therapeutics
2024

Psychometrics of rating scales for externalizing disorders in Japanese outpatients: The ADHD-Rating Scale-5 and the Disruptive Behavior Disorders Rating Scale.

International journal of methods in psychiatric research
2024

An autopsy case of MV 2K + C subtype of Creutzfeldt-Jakob disease.

Neuropathology : official journal of the Japanese Society of Neuropathology
2024

Kuru Disease: Bridging the Gap Between Prion Biology and Human Health.

Cureus
2024

Treatment of trigger finger with metacarpophalangeal joint blocking orthosis vs relative motion extension orthosis: A randomized clinical trial.

Journal of hand therapy : official journal of the American Society of Hand Therapists
2024

Inserting "OFF-to-ON" BODIPY Tags into Cytokines: A Fluorogenic Interleukin IL-33 for Real-Time Imaging of Immune Cells.

ACS central science
2024

Multiple Penile and Scrotal Schwannomas in an Adult Patient: A Case Report.

Urologia internationalis
2024

Nationwide survey of patients with multisystem proteinopathy in Japan.

Annals of clinical and translational neurology
2024

The Relationship Between Health-Related Quality of Life and Overall Survival in Patients With Advanced Renal Cell Carcinoma in CheckMate 214.

The oncologist
2024

The effect of occupational exposure to noise and chemical agents on hearing abilities.

Archives of environmental &amp; occupational health
2024

Affinity-Based Magnetic Nanoparticle Development for Cancer Stem Cell Isolation.

Polymers
2024

Effect of Pre-exercise Sodium Citrate Ingestion on Repeated Sprint Performance in Soccer Players.

Journal of strength and conditioning research
2023

Radical Prostatectomy on YouTube: Education or Disinformation?

Archivos espanoles de urologia
2024

[Evaluation of the GeSRU-Steps educational video concept (German Society of Residents in Urology e. V.)].

Urologie (Heidelberg, Germany)
2024

Anti-inflammatory, antioxidant, antiangiogenic, and therapeutic efficacy of neroli oil in rats with endometriotic lesions.

The journal of obstetrics and gynaecology research
2024

Attitudes of parents of children with ADHD towards genetic testing: Data from a Turkish sample.

Journal of genetic counseling
2024

Treatment of Nocturnal Enuresis Using Miniaturised Smart Mechatronics With Artificial Intelligence.

IEEE journal of translational engineering in health and medicine
2024

Identifying Behavior Change Techniques in an Artificial Intelligence-Based Fitness App: A Content Analysis.

Health education &amp; behavior : the official publication of the Society for Public Health Education
2024

Assessment of wellbore integrity failure risk and hazardous zones in depleted reservoirs underground gas storage during the operation processes.

Environmental science and pollution research international
2023

The impact of the first wave of the COVID-19 pandemic on hospital admissions and treatment management of ectopic pregnancy.

Turkish journal of emergency medicine
2024

A combination of non-invasive tests for the detection of significant fibrosis in patients with metabolic dysfunction-associated steatotic liver disease is not superior to magnetic resonance elastography alone.

European radiology
2023

The concern about the educational quality of online videos on laparoscopic myomectomy.

Revista da Associacao Medica Brasileira (1992)
2023

Mapping Choice of Healthcare Institutes for Cancer Care: A Study in Northeast India.

Asian Pacific journal of cancer prevention : APJCP
2023

Natural history of Becker muscular dystrophy: a multicenter study of 225 patients.

Annals of clinical and translational neurology
2023

Evaluation of the relationship between Ki67 expression level and neoadjuvant treatment response and prognosis in breast cancer based on the Neo-Bioscore staging system.

Discover oncology
2023

Human prion diseases and the prion protein - what is the current state of knowledge?

Translational neuroscience
2023

Investigation of Cognitive Distortions in Panic Disorder, Generalized Anxiety Disorder and Social Anxiety Disorder.

Journal of clinical medicine
2023

Seasonal variation in the expression pattern of heat shock protein 70 and 90 in Common carp (Cyprinus carpio) from Karataş Lake, Burdur, Türkiye.

Veterinary research forum : an international quarterly journal
2023

The effect of hydrogen-rich water on letrozole-induced polycystic ovary syndrome in rats.

Reproductive biomedicine online
2023

Pentraxin-3, endothelin-1, some biochemical parameters and hematology in bovine respiratory disease complex.

Iranian journal of veterinary research
2023

Phase information is conserved in sparse, synchronous population-rate-codes via phase-to-rate recoding.

Nature communications
2023

The prognostic significance of the heterologous component in uterine carcinosarcomas.

Revista da Associacao Medica Brasileira (1992)
2023

First Record, Distribution and Occurrence of A Protistan Entomopathogen, Adelina mesnili Perez (Coccidia: Adeleidae) in the Indian Meal Moth, Plodia interpunctella (Hübner) (Lepidoptera: Pyralidae) Populations in Türkiye.

Turkiye parazitolojii dergisi
2023

Comparison of the effects of alpha lipoic acid and dexpanthenol in an experimental tracheal reconstruction animal model.

Saudi medical journal
2023

A Theoretical Framework on the Biology of Prion Diseases.

Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia &amp; Herzegovina : casopis Drustva za medicinsku informatiku BiH
2023

[Polypharmacy and medication review in the context of prehabilitation].

Urologie (Heidelberg, Germany)
2023

Novel histotypes of sporadic Creutzfeldt-Jakob disease linked to 129MV genotype.

Acta neuropathologica communications
2024

Two-Point Discrimination in Feet with Ankle Sprains.

Journal of the American Podiatric Medical Association
2024

Evaluation of YouTube Information Quality About Pes Planus.

Journal of the American Podiatric Medical Association
2024

Biomechanical Effect of Ankle Ligament Injury in AO Type 44B2.1 Lateral Malleolus Fractures After Lateral Plate Fixation: A Finite Element Analysis.

Journal of the American Podiatric Medical Association
2024

Computational Mechanical Analysis of AO 44A1, 44B1, and 44C1 Fractures with Finite Element Modeling: Evaluation of Screw, Plate, and Kirschner Wire Fixation.

Journal of the American Podiatric Medical Association
2023

Childhood Non-verbal Communication Scale (CNCS): Turkish Adaptation and Psychometric Properties.

Noro psikiyatri arsivi
2024

Case-based report of graded motor imagery experience in traumatic brachial plexus injury: The art of moving without moving.

Journal of hand therapy : official journal of the American Society of Hand Therapists
2023

The prognostic value of P53 index in predicting the recurrence of early low-risk endometrial cancer.

The journal of obstetrics and gynaecology research
2023

Characteristics and predictors of family accommodation in Turkish individuals with obsessive-compulsive disorder.

Turkish journal of medical sciences
2023

Metal-Chelated Polymeric Nanomaterials for the Removal of Penicillin G Contamination.

Polymers
2023

Assessment of Reliability of Three Indices Measuring Gingival Overgrowth.

Acta stomatologica Croatica
2023

Short-term clinical and hormonal effects of a deslorelin implant on late-prepubertal bitches - Based on flare-up signs.

Theriogenology
Ver todos os 305 no EuropePMC

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Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. When I use a word . . . Medical anniversaries in 2026.
    BMJ (Clinical research ed.)· 2026· PMID 41513265mais citado
  2. A Longitudinal Study on Symptom Severity in Early Childhood of Bilingual and Monolingual Children With Autism Spectrum Disorder.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience· 2026· PMID 41472332mais citado
  3. Cross-education after forearm fracture: a randomised controlled trial.
    Irish journal of medical science· 2026· PMID 41196520mais citado
  4. Response to Letter on "Hemostasis Time as a Criterion in Vital Pulpotomy: Methodological and Biological Considerations".
    Medical principles and practice : international journal of the Kuwait University, Health Science Centre· 2026· PMID 41719215mais citado
  5. [Prion diseases : Creutzfeldt-Jakob and differential diagnoses].
    Radiologie (Heidelberg, Germany)· 2026· PMID 41801336mais citado
  6. Lithic Miniaturization Provides a Signature of an MIS4-3 Southern Dispersal of Homo sapiens.
    Evol Anthropol· 2026· PMID 41790047recente
  7. Leveraging the dominant-negative effect of the kuru-protective G127V prion protein variant as a novel therapeutic strategy.
    bioRxiv· 2026· PMID 41757113recente
  8. Prion-induced ferroptosis is facilitated by RAC3.
    Nat Commun· 2025· PMID 40562790recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:454745(Orphanet)
  2. MONDO:0006825(MONDO)
  3. GARD:7617(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Busca completa no PubMed(PubMed)
  6. Artigo Wikipedia(Wikipedia)
  7. Q274615(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Kuru
Compêndio · Raras BR

Kuru

ORPHA:454745 · MONDO:0006825
Prevalência
<1 / 1 000 000
Casos
2.700 casos conhecidos
Herança
Multigenic/multifactorial, Not applicable
CID-10
A81.8 · Outras infecções por vírus atípicos do sistema nervoso central
CID-11
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0022802
EuropePMC
Wikidata
Wikipedia
Papers 10a
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