Introdução
O que você precisa saber de cara
Transtornos do espectro da neuromielite óptica (NMOSD) são um espectro de doenças autoimunes caracterizadas por inflamação aguda do nervo óptico e da medula espinhal (mielite). Episódios de neurite óptica e mielite podem ser simultâneos ou sucessivos. Um curso de doença com recaídas é comum, especialmente em pacientes não tratados. A neuromielite óptica (NMO) é uma doença específica dentro do espectro da NMOSD. É caracterizada por neurite óptica e mielite longitudinalmente extensa. Em mais de 80% dos casos de NMO, a causa são autoanticorpos de imunoglobulina G contra a aquaporina 4 (anti-AQP4), a proteína de canal de água mais abundante no sistema nervoso central.
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Espectro clínico de neuromielite óptica com anticorpos anti-AQP4
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
0 ensaios clínicos encontrados.
Publicações mais relevantes
Isolated Paramedian Pontine Reticular Formation (PPRF) syndrome in AQP4 antibody-positive neuromyelitis optica spectrum disorder: a case report.
Paramedian pontine reticular formation (PPRF) syndrome is characterized by horizontal gaze palsy due to lesions in the PPRF or the abducens nucleus. It is relatively rare and is typically associated with medial longitudinal fasciculus (MLF) syndrome. A 53-year-old Japanese woman presented with right lateral gaze palsy and facial nerve palsy, with preserved convergence and left lateral gaze. Neurological evaluation confirmed PPRF syndrome and facial nerve palsy, with no involvement of the MLF. Brain MRI showed a lesion in the right dorsal pons, affecting the PPRF, abducens nucleus, and facial nerve. Serum testing revealed positive antinuclear and anti-AQP4 antibodies. The patient responded well to immunotherapy, with substantial clinical and radiological improvements. She was ultimately diagnosed with AQP4 antibody-positive NMOSD. This is the first documented case of isolated PPRF syndrome in AQP4 antibody-positive NMOSD. The findings expand the known phenotypic spectrum of NMOSD and highlight the importance of considering NMOSD, with targeted AQP4 antibody testing, in patients presenting with isolated PPRF syndrome.
Progress on experimental models of neuromyelitis optica spectrum disease.
Neuromyelitis optica spectrum disease (NMOSD) is an inflammatory demyelinating disease of the central nervous system (CNS) that primarily affects the optic nerve and spinal cord. At present, the etiology and pathogenesis of NMOSD have not been fully clarified, and its treatment is not perfect, and ideal animal models are a key tool to explore the disease mechanism and screen therapeutic drugs. In recent years, the discovery and confirmation of neuromyelitis optica immunoglobulin G (anti-AQP4 antibodies) as aquaporin-4 (AQP4)-specific antibodies have greatly promoted the study of the pathogenesis of NMOSD, and the study of animal models of NMOSD has become a hot topic of current attention. This article reviews the research progress of NMOSD animal models in recent years, providing a reference for further promoting the in-depth understanding of NMOSD and the formulation of treatment plans.
Neuromyelitis Optica Spectrum Disorder Developing after COVID-19 Vaccination Managed with Long-Term Eculizumab Treatment: A Case Report.
Vaccine-associated neuromyelitis optica spectrum disorder (NMOSD) is rare, especially after COVID-19 vaccination. Furthermore, prior cases generally had specific symptoms. We describe a patient who developed NMOSD following vaccination against COVID-19, whose initial symptoms were intractable hiccups and nausea. Thorough clinical examinations, including blood tests and imaging, immediately after symptom onset did not reveal any abnormal findings, and the anti-aquaporin-4 (AQP4) antibody titer was low. The patient's neurological symptoms (left side-dominant abnormal tingling sensation, touch allodynia, and muscle weakness) progressed. Approximately 5 months after symptom onset, a spinal cord lesion was found along the entire cervical cord that partially involved the thoracic cord. Owing to high anti-AQP4 antibody titers, the patient was diagnosed with AQP4-positive NMOSD. Despite steroid pulse therapy, the patient's neurological symptoms progressed daily, eventually resulting in quadriplegia. Concomitant plasmapheresis gradually improved the patient's muscle strength, and after 2 months of rehabilitation, the patient was discharged home. Before discharge, the patient started maintenance therapy with eculizumab and low-dose steroid therapy. Although she continues to experience some pain and numbness, she has not experienced any relapse for at least 2 years. Owing to the risk of severe disease, such as NMOSD, in patients who initially present with nonspecific neurological symptoms following vaccination, careful examination and monitoring are essential to ensure treatment can be started as soon as possible. Once diagnosed, eculizumab is an effective treatment for patients with AQP4-positive NMOSD following vaccination. Neuromyelitis optica spectrum disorder (NMOSD) is a rare autoimmune disease that affects the brain and nervous system, including the spinal cord and optic nerves. The disease is caused by the immune system, which produces antibodies that mistakenly target a protein, known as aquaporin-4, on the surface of nerve cells. In some patients, this disease develops after vaccination against unrelated infectious diseases. In the last few years, there have been some patients who developed NMOSD after vaccination against SARS-CoV-2, the virus that causes COVID-19. Here, we describe our experience of a patient who developed nonspecific neurological symptoms, including hiccups and weakness, after being vaccinated against SARS-CoV-2. She was diagnosed with aquaporin-4-positive NMOSD about 5 months after the symptoms first appeared. Once this diagnosis was made, she started treatment with eculizumab, a drug that inhibits complement component 5 in the complement cascade, which is part of the immune system. Over 2 years since she started eculizumab, she has not experienced any signs of NMOSD recurrence, although some symptoms, including pain and numbness, continue. Our experience with this patient highlights the risk of developing autoimmune diseases, such as NMOSD, following vaccination. For patients diagnosed with aquaporin-4-positive NMOSD, eculizumab is a potential treatment option that could be considered.
Neuromyelitis Optica Spectrum Disorder Initially Presenting With Meningitis-Like Symptoms: A Case Report.
We report a case of neuromyelitis optica spectrum disorder (NMOSD) relapse in a 45-year-old woman with a known 11-year history of NMOSD, who initially presented with meningitis-like symptoms, including fever, headache, and neck stiffness. Physical examination revealed neck stiffness and positive jolt accentuation, without any other neurological abnormalities. Cerebrospinal fluid (CSF) analysis revealed mononuclear-predominant pleocytosis and hypoglycorrhachia, raising concerns of meningitis. On hospital day 2, brain magnetic resonance imaging (MRI) revealed new hyperintense lesions in the right lateral midbrain and bilateral subcortical regions. That night, the patient developed acute right-sided visual impairment. The patient was diagnosed with NMOSD relapse and was treated with intravenous methylprednisolone pulse therapy, achieving gradual visual improvement. This case highlights that NMOSD can initially present with meningitis-like symptoms, and CSF profiles may resemble those of infectious meningitis. Clinicians should therefore maintain diagnostic vigilance for NMOSD in patients presenting with meningitis-like symptoms, particularly in those with a prior diagnosis of NMOSD or nonadherence to treatment.
Neuromyelitis optica spectrum disorder in an 11-year-old: a case report in a pediatric patient from Nepal.
Neuromyelitis optica spectrum disorder (NMOSD) is an auto-immune inflammatory disorder of the central nervous system mediated by auto-antibodies against Aquaporin-4 (AQP4). It causes vision impairment, vomiting, and paralysis. We report a case of an 11-year-old Nepalese girl who initially presented with persistent vomiting for 2 months, followed by progressive limb weakness and facial asymmetry. She was initially misdiagnosed as gastroduodenitis with mesenteric lymphadenitis and later with major depressive illness and dissociative motor disorder. Neurological examination revealed multiple cranial nerve palsies and upper motor neuron signs. Magnetic resonance imaging (MRI) of the brain and cervical spine demonstrated long segment T2 hyper-intensities involving the medulla, cervicomedullary junction, and cervical spinal cord which was highly suggestive of transverse myelitis with postrema lesions. Serum anti-AQP4 antibody testing done by indirect immunofluorescence assay was positive which confirmed NMOSD. The patient was treated with intravenous methylprednisolone pulse therapy followed by intravenous immunoglobulin and transitioned to oral prednisolone with gradual improvement in neurological function. This case highlights diagnostic challenge of NMOSD, particularly when presented with area postrema syndrome without early neurological findings. Such atypical presentations are frequently mistaken for gastrointestinal or psychiatric conditions, delaying appropriate diagnosis and management. MRI findings and a positive anti-AQP-4 antibody remain key to confirming the diagnosis. Early initiation of immunotherapy is essential to prevent irreversible neurological deficits. NMOSD should be considered in children presenting with unexplained persistent vomiting and subsequent neurological deficits. A high index of suspicion, prompt antibody testing, and timely immunotherapy are vital for favorable outcomes.
Publicações recentes
Isolated Paramedian Pontine Reticular Formation (PPRF) syndrome in AQP4 antibody-positive neuromyelitis optica spectrum disorder: a case report.
Low prevalence of inflammatory bowel disease among patients with seropositive neuromyelitis optica spectrum disorder in two large referral centers.
Double-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.
Clinical insights and risk factors for disability in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder patients: a multicenter real-world study in Greece.
Clinical and epidemiological characteristics of late-onset neuromyelitis optica at a tertiary care hospital in Central America.
📚 EuropePMCmostrando 198
Neuromyelitis Optica Spectrum Disorder Initially Presenting With Meningitis-Like Symptoms: A Case Report.
CureusNeuromyelitis optica spectrum disorder in an 11-year-old: a case report in a pediatric patient from Nepal.
Annals of medicine and surgery (2012)Isolated Paramedian Pontine Reticular Formation (PPRF) syndrome in AQP4 antibody-positive neuromyelitis optica spectrum disorder: a case report.
BMC neurologyCase Report: Organizing pneumonia associated with AQP4-antibody neuromyelitis optica spectrum disorder in children.
Frontiers in pediatricsLow prevalence of inflammatory bowel disease among patients with seropositive neuromyelitis optica spectrum disorder in two large referral centers.
Multiple sclerosis and related disordersProgress on experimental models of neuromyelitis optica spectrum disease.
IBRO neuroscience reportsNeuromyelitis Optica Spectrum Disorder Developing after COVID-19 Vaccination Managed with Long-Term Eculizumab Treatment: A Case Report.
Case reports in neurologyHyperperfusion Improvement: A Potential Therapeutic Marker in Neuromyelitis Optica Spectrum Disorder (NMOSD).
Diagnostics (Basel, Switzerland)Double-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.
BMC neurologyChanges in T lymphocyte subsets in patients with acute neuromyelitis optica spectrum disorder.
Frontiers in immunologyMycoplasma pneumoniae infection and concurrent aquaporin-4-positive neuromyelitis optica spectrum disorder: a case report and literature review.
BMC pediatricsClinical insights and risk factors for disability in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder patients: a multicenter real-world study in Greece.
Multiple sclerosis and related disordersClinical and epidemiological characteristics of late-onset neuromyelitis optica at a tertiary care hospital in Central America.
Multiple sclerosis and related disorders[AQP4 positive neuromyelitis optica spectrum disorder: an atypical pathology with nerve root enlargement and peripheral nervous system damage in demyelination].
Rinsho shinkeigaku = Clinical neurologyEffective Control of Neuropathic Pain With Amitriptyline in Neuromyelitis Optica Spectrum Disorder: A Case Report.
CureusEfficacy of mycophenolate mofetil for the maintenance therapy of anti-AQP4 antibody-positive NMOSD complying with probable sjögren's disease in a 2-year-old girl: a case report.
Pediatric rheumatology online journal[A case of recurrence after more than 20 years from transverse myelitis suspected to be neuromyelitis optica spectrum disorder].
Rinsho shinkeigaku = Clinical neurologyThe role of IL-39 in autoimmune diseases: From general to immunopathogenesis.
CytokineEarly neuromyelitis optica antibody-induced molecular changes in aquaporin 4 and associated proteins at astrocyte endfeet in murine brain tissues.
Journal of pharmacological sciencesAnti-IL-6R antibody treatment changes microglial phenotype in AQP4 peptide-immunized mice, leading to suppression of myelitis severity.
Journal of neuroimmunologyConfusing Onset of MOGAD in the Form of Focal Seizures.
Neurology internationalTranscriptome signature in the blood of neuromyelitis optica spectrum disorder under steroid tapering.
Frontiers in immunologyNovel Automated Chemiluminescent Immunoassay for the Detection of Autoantibodies Against Aquaporin-4 in Neuromyelitis Optica Spectrum Disorders.
Diagnostics (Basel, Switzerland)Neuromyelitis Optica Spectrum Disorder with Interstitial Pneumonia and Marked HyperCKemia as an Initial Presentation: A Case Report and Literature Review.
The Tohoku journal of experimental medicineInebilizumab treatment in a patient with co-occurring AQP4-IgG positive neuromyelitis optica spectrum disorder and myasthenia gravis: a case report and literature review.
Frontiers in immunologyClinical characteristics of anti-myelin oligodendrocyte glycoprotein antibody among aquaporin-4 negative neuromyelitis optica spectrum disorders in Egyptian patients.
Scientific reportsPrevalence of, and Disability Due to, Multiple Sclerosis and Neuromyelitis Optica Spectrum Disorder in Japan by the Fifth Nationwide Survey.
Neurology[Efficacy and Safety of Inebilizumab, an Anti-CD19 Monoclonal Antibody, for the Treatment of Neuromyelitis Optica Spectrum Disorder: Based on the N-MOmentum Trial].
Brain and nerve = Shinkei kenkyu no shinpoPolyautoimmunity and multiple autoimmune syndrome in patients with neuromyelitis optica spectrum disorder.
Multiple sclerosis and related disordersA rare case of systemic lupus erythematosus-associated neuromyelitis optica spectrum disorder with cystic lesions and dual seropositivity for anti-AQP4 and anti-MOG antibodies.
Clinical case reportsHumanized-Aquaporin-4-Expressing Rat Created by Gene-Editing Technology and Its Use to Clarify the Pathology of Neuromyelitis Optica Spectrum Disorder.
International journal of molecular sciencesHematopoietic stem cell transplantation for neuromyelitis optica spectrum disorder. Can immune tolerance be reestablished?
Handbook of clinical neurologyRelapsing meningitis and limbic encephalitis in anti-AQP4-Ab-associated neuromyelitis optica spectrum disorder.
Multiple sclerosis (Houndmills, Basingstoke, England)Neuromyelitis in a Patient with Rheumatoid Arthritis: A Case Report.
Archives of Iranian medicineCancer-associated neuromyelitis optica spectrum disorder: a case report with literature review.
Rinsho shinkeigaku = Clinical neurologySuccessful treatment with efgartigimod as an add-on therapy in acute attack of anti-AQP4 antibody-positive NMOSD: a case report.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyNeuromyelitis Optica Spectrum Disorders (NMOSDs) Diagnosed After Surgery for the Ossification of the Posterior Longitudinal Ligament of the Cervical and Thoracic Spine: A Case Report.
CureusComparison of efficacy of plasma exchange versus intravenous immunoglobulin as an add-on therapy in acute attacks of neuromyelitis optica spectrum disorder.
Journal of clinical apheresisAn Aberrant Case of Neuromyelitis Optica Spectrum Disorder With a Review of Literature.
CureusWhole spinal transverse myelitis in neuromyelitis optica spectrum disorder.
Multiple sclerosis and related disordersCorrelation between severe attacks and serum aquaporin-4 antibody titer in neuromyelitis optica spectrum disorder.
Journal of neurologyStage-dependent immunity orchestrates AQP4 antibody-guided NMOSD pathology: a role for netting neutrophils with resident memory T cells in situ.
Acta neuropathologicaEstablishment of novel cell lines that maintain the features of B cells derived from patients with neuromyelitis optica spectrum disorder.
Immunological medicineClinical Research into Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines.
Diseases (Basel, Switzerland)Infrequent patterns in cerebrospinal fluid isofocusing test: Clinical significance and contribution of IgG index and Reiber diagram to their interpretation.
Multiple sclerosis and related disordersPeripheral memory B cells in multiple sclerosis vs. double negative B cells in neuromyelitis optica spectrum disorder: disease driving B cell subsets during CNS inflammation.
Frontiers in cellular neuroscienceB cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4.
NatureCD11chigh B Cell Expansion Is Associated With Severity and Brain Atrophy in Neuromyelitis Optica.
Neurology(R) neuroimmunology & neuroinflammationAnti-aquaporin-4 immune complex stimulates complement-dependent Th17 cytokine release in neuromyelitis optica spectrum disorders.
Scientific reportsNeuromyelitis optica associated with the use of Atezolizumab in a patient with advanced lung adenocarcinoma.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyNeuromyelitis optica spectrum disorder with herpes simplex viral infection presenting with syndrome of inappropriate antidiuretic hormone: A case report.
Medicine[A case of neuromyelitis optica spectrum disorder after human immunodeficiency virus infection treated with rituximab].
Rinsho shinkeigaku = Clinical neurologyLong-term Effects of IL-6 Receptor Blockade Therapy on Regulatory Lymphocytes and Neutrophils in Neuromyelitis Optica Spectrum Disorder.
Neurology(R) neuroimmunology & neuroinflammationProbable eculizumab-associated hepatotoxicity in a patient with neuromyelitis optica: a case report.
The International journal of neuroscienceNeuromyelitis Optica Spectrum Disorder Mimicking Pontine Stroke: A Case Report and Systematic Literature Review.
CureusOverlap syndrome of anti-aquaporin 4 positive neuromyelitis optica spectrum disorder and primary Sjögren's syndrome: a systematic review of individual patient data.
Rheumatology internationalOverlap syndrome of anti-aquaporin-4 positive neuromyelitis optica spectrum disorder and systemic lupus erythematosus: A systematic review of individual patient data.
LupusSecondary immunoreaction in patients with neurosyphilis and its relevance to clinical outcomes.
Frontiers in neurology[Neuromyelitis optica spectrum disorder in a patient with human immunodeficiency virus].
Revista medica del Instituto Mexicano del Seguro SocialEstablishment of a comprehensive diagnostic model for neuromyelitis optica spectrum disorders based on the analysis of laboratory indicators and clinical data.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyEffectiveness of rituximab versus oral immunosuppressive therapies in neuromyelitis optica spectrum disorder in a racially diverse cohort of subjects: A single-center retrospective study.
Multiple sclerosis and related disordersClinical characteristics of late-onset neuromyelitis optica spectrum disorder.
Multiple sclerosis and related disordersA case report of neuromyelitis optica spectrum disorder induced by pembrolizumab treatment for lung adenocarcinoma: a clinical and immunohistochemical study.
BMC neurologyAutoimmune Myelitis and Myocarditis in a Patient With Anti-Aquaporin-4, Antinuclear, and Antiphospholipid Autoantibodies: The Neuromyelitis Optica-Systemic Lupus Erythematosus (NMO-SLE) Overlap Syndrome.
CureusNeuromyelitis optica spectrum disorder: pathophysiological approach.
The International journal of neuroscienceA Quality Assessment of Aquaporin-4 & Myelin Oligodendrocyte Glycoprotein Antibody Testing.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiquesA Case of Neuromyelitis Optica with Systemic Lupus Erythematosus.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSPDouble seropositive neuromyelitis optica associated with COVID-19: A case report.
Frontiers in neurologyA novel aquaporin-4-associated optic neuritis rat model with severe pathological and functional manifestations.
Journal of neuroinflammationFirst manifestation of AQP4-IgG-positive neuromyelitis optica spectrum disorder following the COVID-19 mRNA vaccine BNT162b2.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyThe Prevalence, Demographics, Clinical Features, Neuroimaging, and Inter-ethnic Differences of MOGAD in Malaysia with Global Perspectives.
Multiple sclerosis and related disordersEnlarged perivascular spaces, neuroinflammation and neurological dysfunction in NMOSD patients.
Frontiers in immunologyRe-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromes.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology SocietyNeuromyelitis Optica Spectrum Disorders in Black African: Experience of Togo (2015-2020).
Journal of neurosciences in rural practiceNeuromyelitis optica spectrum disorders and anti-myelin oligodendrocyte glycoprotein positive optic neuropathies.
International journal of ophthalmology[Local experience of IL-6 pathway inhibition with satralizumab for patients with neuromyelitis optica spectrum disorder].
Zhurnal nevrologii i psikhiatrii imeni S.S. KorsakovaClinical features of organizing pneumonia in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorders.
Respiratory investigationStrategies to Screen Anti-AQP4 Antibodies from Yeast Surface Display Libraries.
Antibodies (Basel, Switzerland)Neuromyelitis optica spectrum disorder: do patients positive and negative for anti-aquaporin-4 antibodies present distinct entities? A Colombian perspective.
NeurologiaImmuno-pathogenesis of neuromyelitis optica and emerging therapies.
Seminars in immunopathologyLate onset neuromyelitis optica spectrum disorders (LONMOSD) from a nationwide Portuguese study: Anti-AQP4 positive, anti-MOG positive and seronegative subgroups.
Multiple sclerosis and related disordersFollow-up of retinal thickness and optic MRI after optic neuritis in anti-MOG antibody-associated disease and anti-AQP4 antibody-positive NMOSD.
Journal of the neurological sciences[Seroconversion of anti-aquaporin-4 antibody in a patient with neuromyelitis optica spectrum disorder: a case report].
Rinsho shinkeigaku = Clinical neurologyNeuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study.
Neurology internationalTreatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study.
Journal of neuroinflammationPathological observations of a long spinal cord lesion in a patient with multiple sclerosis.
Neuropathology : official journal of the Japanese Society of NeuropathologyAnti-aquaporin-4 immunoglobulin G colorimetric detection by silver nanoparticles.
Nanomedicine : nanotechnology, biology, and medicineCLINICAL CASE OF NEUROMYELITIS OPTICA SPECTRUM DISORDERS IN YOUNG WOMAN TREATED WITH RITUXIMAB.
Wiadomosci lekarskie (Warsaw, Poland : 1960)Pediatric neuromyelitis optica spectrum disorders in Portugal: A multicentre retrospective study.
Multiple sclerosis and related disordersOptical coherence tomography angiography (OCTA) in differential diagnosis of aquaporin-4 antibody seronegative NMOSD and multiple sclerosis.
Multiple sclerosis and related disordersDevelopment of Paraneoplastic Neuromyelitis Optica after Lung Resection in a Patient with Squamous Cell Carcinoma.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of AsiaAcute Demyelinating Syndromes: A report of child neurology department of Sfax University Hospital.
Multiple sclerosis and related disordersRegulatory T cells protect against brain damage by alleviating inflammatory response in neuromyelitis optica spectrum disorder.
Journal of neuroinflammationInebilizumab for treatment of neuromyelitis optica spectrum disorder.
Neurodegenerative disease managementFive-year visual outcomes after optic neuritis in anti-MOG antibody-associated disease.
Multiple sclerosis and related disordersAre Zika virus cross-reactive antibodies against aquaporin-4 associated to Neuromyelitis Optica Spectrum Disorder?
Journal of neuroimmunology[A case of neuromyelitis optica associated with pulmonary Mycobacterium avium complex disease].
Rinsho shinkeigaku = Clinical neurologyAnti-AQP4 autoantibodies promote ATP release from astrocytes and induce mechanical pain in rats.
Journal of neuroinflammationConus medullaris involvement in demyelinating disorders of the CNS: A comparative study.
Multiple sclerosis and related disordersSerum Immunoglobulin G Level and Neutrophils to Lymphocytes Ratio Associated with the Prognosis of Neuromyelitis Optica Spectrum Disorder.
Current neurovascular researchStatus of the neuromyelitis optica spectrum disorder in Latin America.
Multiple sclerosis and related disordersMolecular Level Characterization of Circulating Aquaporin-4 Antibodies in Neuromyelitis Optica Spectrum Disorder.
Neurology(R) neuroimmunology & neuroinflammationClinical characteristics of intractable or persistent hiccups and nausea associated with herpes zoster.
Clinical neurology and neurosurgery[A Case of Neuromyelitis Optica Spectrum Disorder Who Relapsed Under Oral Corticosteroid Treatment with Multiple Cerebrospinal Lesions and Severe Neurological Deficits].
Journal of UOEHDifference in the Source of Anti-AQP4-IgG and Anti-MOG-IgG Antibodies in CSF in Patients With Neuromyelitis Optica Spectrum Disorder.
NeurologyParaneoplastic neuromyelitis optica spectrum disorder associated with malignant melanoma: A case report.
Thoracic cancerDementia and Parkinson-like syndrome with basal ganglia lesion in neuromyelitis optica spectrum disorders.
Neurocase[Clinical characteristics in 40 patients with longitudinally extensive transverse myelitis and connective tissue disease].
Zhonghua nei ke za zhiLongitudinally Extensive Transverse Myelitis: A Retrospective Study Differentiating Neuromyelitis Optica Spectrum Disorder From Other Etiologies.
CureusCorrelations among disability, anti-AQP4 antibody status and prognosis in the spinal cord involved patients with NMOSD.
BMC neurologyAnti-aquaporin 4 IgG Is Not Associated With Any Clinical Disease Characteristics in Neuromyelitis Optica Spectrum Disorder.
Frontiers in neurologyLongitudinal Evaluation of Serum MOG-IgG and AQP4-IgG Antibodies in NMOSD by a Semiquantitative Ratiometric Method.
Frontiers in neurologyMeningitis as a recurrent manifestation of anti-AQP4/anti-MOG negative neuromyelitis optica spectrum disorder: a case report.
BMC neurologyThe efficacy of rituximab in patients with neuromyelitis optica spectrum disorder: A real-world study from Turkey.
International journal of clinical practiceSatralizumab: an interleukin-6 (IL-6) receptor antagonist for the treatment of neuromyelitis optica spectrum disorders.
Drugs of today (Barcelona, Spain : 1998)Efficacy for the Annual Relapse Rate after the Immunosuppressive Therapy in Patients Associated with Anti-AQP4 or Anti-MOG Antibody-Positive Optic Neuritis.
Journal of ophthalmologyOptic neuritis after ocular trauma in anti-aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder.
Brain and behavior[A case of spinal cord infarction accompanied with neuromyelitis optica spectrum pathophysiology].
Rinsho shinkeigaku = Clinical neurologyAnti-MOG associated disorder-Clinical and radiological characteristics compared to AQP4-IgG+ NMOSD-A single-center experience.
Multiple sclerosis and related disordersAquaporin-4-antibody-positive Neuromyelitis Optica Spectrum Disorder in a Patient with Charcot-Marie-Tooth Disease Type 1A.
Internal medicine (Tokyo, Japan)Benefits of eculizumab in AQP4+ neuromyelitis optica spectrum disorder: Subgroup analyses of the randomized controlled phase 3 PREVENT trial.
Multiple sclerosis and related disordersA case of anti-AQP4 antibody-positive neuromyelitis optica spectrum disorder with MRI-proven lesions in lumbar nerve roots.
Multiple sclerosis and related disordersA case of anti-aquaporin-4 antibody-positive optic neuritis treated by selective immunoadsorption.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for HaemapheresisAdvances in the Treatment of Neuromyelitis Optica Spectrum Disorder.
Neurologic clinicsRituximab efficacy at different initial and maintenance doses in neuromyelitis optica spectrum disorder: Experience from a national health institute in México.
Journal of the neurological sciencesRecurrent optic neuritis in a patient with Sjogren syndrome and neuromyelitis optica spectrum disorder: A case report.
MedicineTwo cases of NMOSD with MRI findings mimicking CADASIL.
Multiple sclerosis and related disordersClinical outcomes of transverse myelitis with myelin oligodendrocyte glycoprotein antibody versus negative cases among adults in Isfahan, Iran: A comparative study.
Current journal of neurologyAquaporin-4 Expression during Toxic and Autoimmune Demyelination.
CellsEculizumab in the treatment of neuromyelitis optica spectrum disorder.
ImmunotherapyMitochondrial DNA enhance innate immune responses in neuromyelitis optica by monocyte recruitment and activation.
Scientific reportsRecurrent episodes of syncope requiring pacemaker implantation as an initial presentation of neuromyelitis optica spectrum disorder.
Multiple sclerosis and related disordersAn update on epidemiology, diagnosis & management of NMO-SD in the tertiary neurology department of Marrakech (Morocco).
Revue neurologiqueThe relationship between aquaporin-4 antibody status and visual tract integrity in neuromyelitis optica spectrum disorders: A visual evoked potential study.
Multiple sclerosis and related disordersUnilateral Optic Neuritis in Children: Experience of a Tertiary Centre.
European neurologyEffect of rituximab on disease activity in latin American patients with anti-aquaporin-4 (+) neuromyelitis optica spectrum disorder.
Clinical neurology and neurosurgeryAnti-MOG and Anti-AQP4 positive neuromyelitis optica spectrum disorder in a patient with myasthenia gravis.
Multiple sclerosis and related disordersMoving beyond anti-aquaporin-4 antibodies: emerging biomarkers in the spectrum of neuromyelitis optica.
Expert review of neurotherapeuticsA new M23-based ELISA assay for anti-aquaporin 4 autoantibodies: diagnostic accuracy and clinical correlation.
Auto- immunity highlightsCurrent and emerging biologics for the treatment of neuromyelitis optica spectrum disorders.
Expert opinion on biological therapyNeuromyelitis optica spectrum disorders in Arabian Gulf (NMOAG); establishment and initial characterization of a patient registry.
Multiple sclerosis and related disordersClinical and immunological differences between MOG associated disease and anti AQP4 antibody-positive neuromyelitis optica spectrum disorders: Blood-brain barrier breakdown and peripheral plasmablasts.
Multiple sclerosis and related disordersTwo Cases of Very-Late-Onset Neuromyelitis Optica Spectrum Disorder (NMOSD) in Patients over the Age of 80.
Case reports in neurologyUse of ganglion cell layer analysis for diagnosing anti-glycoprotein neuromyelitis optica of oligodendrocyte myelin.
Archivos de la Sociedad Espanola de OftalmologiaTacrolimus is effective for neuromyelitis optica spectrum disorders with or without anti-AQP4 antibody.
Multiple sclerosis and related disordersHLA-G Ins/Del polymorphism and +3142C/G SNP are not related to neuromyelitis optica spectrum disorder (NMOSD) development, disability status or anti-aquaporin 4 presence in Brazilian patients.
Journal of neuroimmunologyPredictive Value of Serum Antibodies and Point Mutations of AQP4, AQP1 and MOG in A Cohort of Spanish Patients with Neuromyelitis Optica Spectrum Disorders.
International journal of molecular sciences[Optic neuropathy in positive anti-MOG antibody syndrome].
Journal francais d'ophtalmologieHA280 immunoadsorption, an alternative treatment for neuromyelitis optica spectrum disorders?
Multiple sclerosis and related disordersNeuromyelitis optica spectrum disorders in South of Tunisia: A rare entity with low seroprevalence of anti-aquaporin 4 autoantibodies.
Revue neurologiqueAffinity-matured 'aquaporumab' anti-aquaporin-4 antibody for therapy of seropositive neuromyelitis optica spectrum disorders.
NeuropharmacologyGRP 78 antibodies are associated with clinical phenotype in neuromyelitis optica.
Annals of clinical and translational neurologyThe accuracy of flow cytometric cell-based assay to detect anti-myelin oligodendrocyte glycoprotein (MOG) antibodies determining the optimal method for positivity judgement.
Journal of neuroimmunologyIntractable axonal neuropathy with multifocal peripheral nerve swelling in neuromyelitis optica spectrum disorders: A case report.
Multiple sclerosis and related disordersIncidence of pediatric neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease in Denmark 2008‒2018: A nationwide, population-based cohort study.
Multiple sclerosis and related disordersDisease course, progression and activity of neuromyelitis optica (NMOSD) in patients who were treated with Rituximab, 6 and 12 months after receiving the first dose of drug, in Isfahan city.
Multiple sclerosis and related disordersOptic neuritis, encephalitis and leptomeningeal enhancement in a patient with anti-MOG antibodies: A case study.
Multiple sclerosis and related disordersAssessment of lesions on magnetic resonance imaging in multiple sclerosis: practical guidelines.
Brain : a journal of neurologyThe clinical spectrum of anti-MOG associated acquired demyelinating disorders: Three case-reports.
Multiple sclerosis and related disordersHLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients.
Arquivos de neuro-psiquiatriaEarly B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production.
Brain : a journal of neurologyHuman Serum Anti-aquaporin-4 Immunoglobulin G Detection by Cell-based Assay.
Journal of visualized experiments : JoVECase report: an area postrema syndrome revealing a neuromyelitis optica spectrum disorder associated with central nervous system tuberculosis in a young Togolese (black African) woman.
BMC neurologyInhibitors of Mammalian Aquaporin Water Channels.
International journal of molecular sciencesQuantitative 7T MRI does not detect occult brain damage in neuromyelitis optica.
Neurology(R) neuroimmunology & neuroinflammation[Neuromyelitis optica spectrum disorders positive for anti-AQP4 antibody associated with myasthenia gravis: A literature review].
Journal francais d'ophtalmologiePontine hemorrhage accompanied by neuromyelitis optica spectrum disorder.
Journal of neuroimmunologyAstrocytic damage in glial fibrillary acidic protein astrocytopathy during initial attack.
Multiple sclerosis and related disordersArea postrema syndrome: Another feature of anti-GFAP encephalomyelitis.
Multiple sclerosis (Houndmills, Basingstoke, England)Neurological Complications of Sjögren's Syndrome: Diagnosis and Management.
Current treatment options in rheumatologyNeuromyelitis optica spectrum disorder: Pathogenesis, treatment, and experimental models.
Multiple sclerosis and related disordersClinical characteristics of 153 Brazilian patients with neuromyelitis optica spectrum disorder (NMOSD).
Multiple sclerosis and related disordersRituximab-induced hypogammaglobulinemia in patients with neuromyelitis optica spectrum disorders.
Neurology(R) neuroimmunology & neuroinflammationPrevalence of anti-aquaporin 4 antibody in a diagnostic cohort of patients being investigated for possible neuromyelitis optica spectrum disorder in Western Australia.
Journal of neuroimmunology[Demyelinating disorders].
MedicinaDiagonistic Apraxia: A Unique Case of Corpus Callosal Disconnection Syndrome and Neuromyelitis Optica Spectrum Disorder.
Frontiers in neurologyDevic's syndrome and mixed connective tissue disease: an unusual association.
Acta reumatologica portuguesaHelicobacter pylori infection and demyelinating disease of the central nervous system.
Journal of neuroimmunologyIntractable nausea and vomiting as an uncommon presentation in an anti-aquaporin 4-positive patient.
The Journal of international medical researchNeuromyelitis optica in Sub-Saharan Africa: the first case report from Togo.
Medecine et sante tropicalesImmunoadsorption plasmapheresis treatment for the recurrent exacerbation of neuromyelitis optica spectrum disorder with a fluctuating anti-aquaporin-4 antibody level.
Journal of artificial organs : the official journal of the Japanese Society for Artificial OrgansRefractory neuromyelitis optica spectrum disorder in systemic lupus erythematosus successfully treated with rituximab.
LupusRecombinant IgG1 Fc hexamers block cytotoxicity and pathological changes in experimental in vitro and rat models of neuromyelitis optica.
NeuropharmacologyNeuromyelitis optica spectrum disorder secondary to treatment with anti-PD-1 antibody nivolumab: the first report.
BMC cancerThe single nucleotide polymorphism site of aquaporin-4 gene in patients with neuromyelitis optica.
Experimental and therapeutic medicineSubclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica.
Journal of neuroimmunologyRadiculopathy in neuromyelitis optica. How does anti-AQP4 Ab involve PNS?
Multiple sclerosis and related disorders[A case of recurrent myelitis associated with anti-myelin oligodendrocyte glycoprotein antibody that developed only as localized short spinal cord lesions].
Rinsho shinkeigaku = Clinical neurologyGender differences among Chinese patients with neuromyelitis optica spectrum disorders.
Multiple sclerosis and related disordersAnti-aquaporin-4 titer is not predictive of disease course in neuromyelitis optica spectrum disorder: A multicenter cohort study.
Multiple sclerosis and related disordersA case of MOG antibody-positive bilateral optic neuritis and meningoganglionitis following a genital herpes simplex virus infection.
Multiple sclerosis and related disordersDiagnostics of the neuromyelitis optica spectrum disorders (NMOSD).
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology[Clinical characteristics of neuromyelitis optica spectrum disorders associated with syringomyelia].
Zhonghua yi xue za zhiGlucose-regulated protein 78 autoantibody associates with blood-brain barrier disruption in neuromyelitis optica.
Science translational medicineAquaporin-4 antibody positive neuromyelitis optica spectrum disorder associated with esophageal cancer.
Journal of neuroimmunologyA Case of Primary Sjögren's Syndrome Presenting as Mass-Like Encephalitis, With Progression to Neuromyelitis Optica Spectrum Disorder.
Archives of rheumatologyScreening for onconeural antibodies in neuromyelitis optica spectrum disorders.
BMC neurologyDeletional tolerance prevents AQP4-directed autoimmunity in mice.
European journal of immunologyAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Espectro clínico de neuromielite óptica com anticorpos anti-AQP4.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Espectro clínico de neuromielite óptica com anticorpos anti-AQP4
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Ainda não achamos doenças com sintomas parecidos o suficiente.
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Isolated Paramedian Pontine Reticular Formation (PPRF) syndrome in AQP4 antibody-positive neuromyelitis optica spectrum disorder: a case report.
- Progress on experimental models of neuromyelitis optica spectrum disease.
- Neuromyelitis Optica Spectrum Disorder Developing after COVID-19 Vaccination Managed with Long-Term Eculizumab Treatment: A Case Report.
- Neuromyelitis Optica Spectrum Disorder Initially Presenting With Meningitis-Like Symptoms: A Case Report.
- Neuromyelitis optica spectrum disorder in an 11-year-old: a case report in a pediatric patient from Nepal.
- Low prevalence of inflammatory bowel disease among patients with seropositive neuromyelitis optica spectrum disorder in two large referral centers.
- Double-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.
- Clinical insights and risk factors for disability in aquaporin-4-IgG-positive neuromyelitis optica spectrum disorder patients: a multicenter real-world study in Greece.
- Clinical and epidemiological characteristics of late-onset neuromyelitis optica at a tertiary care hospital in Central America.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:592850(Orphanet)
- MONDO:0035663(MONDO)
- Neuromielite Optica(PCDT · Ministério da Saúde)
- GARD:22372(GARD (NIH))
- Busca completa no PubMed(PubMed)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
