O campo da epilepsia autoimune evoluiu substancialmente nas últimas décadas com a descoberta de vários autoanticorpos neurais e com uma melhor compreensão dos mecanismos destas síndromes imunomediadas. Foi demonstrado que uma proporção considerável de doentes com epilepsia de etiologia desconhecida tem uma causa autoimune. A maioria dos doentes com epilepsia autoimune apresenta geralmente convulsões refractárias de início recente, juntamente com declínio cognitivo progressivo subagudo e disfunção comportamental ou psiquiátrica. Os anticorpos neurais específicos habitualmente associados à epilepsia autoimune incluem a proteína 1 (LGI1) activada por glioma rica em leucina, o recetor N-metil-d-aspartato (NMDA-R) e a IgG da descarboxilase do ácido glutâmico 65 (GAD65).
Introdução
O que você precisa saber de cara
Mielite transversa aguda com anticorpos anti-MOG é uma doença inflamatória rara que afeta a medula espinhal, causando sintomas neurológicos súbitos. O sistema imunológico ataca erroneamente a mielina, camada protetora dos nervos, levando a danos e disfunção.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Mielite transversa aguda com anticorpos anti-MOG
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
Overlapping autoimmunity and demyelination syndromes associated with TNF inhibitor therapy.
Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is a demyelinating disorder of the central nervous system. We describe a case of a 31-year-old male with ankylosing spondylitis who developed optic neuritis and transverse myelitis accompanied by positive anti-MOG antibodies, and subsequently features consistent with systemic lupus erythematosus (SLE), beginning 3 months after initiating adalimumab. Adalimumab was discontinued, and the patient was treated with pulsed intravenous methylprednisolone followed by rituximab with significant improvement in clinical, imaging, and laboratory manifestations of the disease. This case highlights a rare constellation of overlapping autoimmune diseases, with both MOGAD and SLE emerging after anti-TNF antibody exposure in a patient with ankylosing spondylitis.
Double-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.
Double seronegative neuromyelitis optica spectrum disorder (DN-NMOSD) is a rare autoimmune disease of the central nervous system, typically involving the optic nerve and spinal cord, characterized by negativity for anti-AQP4 and anti-MOG antibodies. A 35-year-old man with optic neuritis and recurrent myelitis, negative for AQP4 and MOG antibodies, was diagnosed with double seronegative NMOSD (DN-NMOSD). Initial treatment with Rituximab led to temporary stability, but relapses in 2021 and 2022 prompted a switch to Satralizumab (anti-IL-6R), achieving two years of clinical and radiological stability. This case underscores the therapeutic potential of anti-IL-6 drugs for DN-NMOSD, especially when anti-CD20 therapies fail. It highlights the heterogeneity of DN-NMOSD and the need for novel biomarkers, such as GFAP, tau, and IL-6, to better understand disease mechanisms and guide targeted treatments. A structured therapeutic approach, starting with anti-CD20 drugs and progressing to anti-IL-6 agents if ineffective, may optimize outcomes in this poorly understood condition.
Impact of Anti-MOG Antibody in Diagnosis of Autoimmune Diseases of the Central Nervous System in Children: A Case Series.
Autoimmune diseases of the central nervous system in children present a significant diagnostic challenge due to their heterogeneous nature. The identification of anti-myelin oligodendrocyte glycoprotein (MOG) antibodies has contributed to our understanding and classification of these disorders.This study aims to characterize the clinical, paraclinical, and neuroimaging findings in pediatric patients diagnosed with acquired demyelinating syndromes (ADS) and autoimmune encephalitis (AE).Conducted as a descriptive case series, this study retrospectively analyzed medical records of children under 18 years diagnosed with ADS or AE from January 2017 to February 2022. We employed basic descriptive statistics to analyze patient demographics, clinical presentations, laboratory findings, and neuroimaging results.A total of 71 cases were evaluated, with 80% classified as ADS and 20% as AE. Within ADS, acute disseminated encephalomyelitis and optic neuritis were the most prevalent at 19%, followed by pediatric-onset multiple sclerosis at 17%, and transverse myelitis at 16%. AE cases were predominantly seropositive (93%), with a vast majority (92%) showing anti-NMDAR antibodies compared with 8% with anti-MOG antibodies. Since MOG antibody measurement became available at our institution in 2020, many new cases have been diagnosed as MOGAD (MOG antibody-associated disease), a new entity with different clinical manifestations.In children demyelinating disorders are more frequent than autoimmune encephalitis. New biomarkers, such as anti-MOG antibodies, have led to a better understanding of pediatric autoimmune CNS diseases. The study underscores the necessity of continuous reevaluation of diagnostic criteria and treatment protocols considering emerging biomarkers in neuroimmunology.
Coronavirus Disease 2019 Infection and Vaccination in Pediatric Demyelinating Diseases.
As compared to adults, less is known about the effects of SARS-CoV-2 infection in children with neuroinflammatory diseases, such as multiple sclerosis (MS), anti-myelin oligodendrocyte glycoprotein associated disease (MOGAD), and neuromyelitis optica spectrum disorder (NMOSD). Moreover, the effects of SARS-CoV-2 vaccination on pediatric demyelinating diseases is also lesser known. Here, we examine the effects of SARS-CoV-2 infection and vaccination on children with demyelinating diseases. Retrospective chart review was performed at a single tertiary pediatric center, including 116 children with demyelinating diagnoses (MOGAD, MS, NMOSD, transverse myelitis-TM, and acute disseminated encephalomyelitis). Descriptive statistics and logistic regression were used. The diagnoses included: MS: 56/116 = 48%, MOGAD: 32/116 = 28%, NMOSD: 15/116 = 13%, acute disseminated encephalomyelitis: 12/116 = 10%, and TM: 1/116 = 1%. The known COVID infection rate was 26% = 30/116. Three of 30 (10%) of those with known infection were hospitalized. None of those hospitalized required intubation or ICU admission. Of the 30 with known infection, two (7%) had neuroinflammatory events that occurred within four weeks of infection, both of which were their first clinical events for MS. SARS-CoV-2 vaccination was not associated with any new onset or relapse neuroinflammatory events in our cohort. Demyelinating diagnosis and anti-CD20 mAbs were associated with known SARS-CoV-2 infection. Two participants had an initial clinical MS event associated with infection. However, we found no association with SARS-COV-2 vaccination or infection with relapses and no long-term adverse outcomes with SARS-CoV-2 vaccination or infection. Future larger multicenter studies should prospectively compare how infection and vaccination affects children and adults with demyelinating diseases.
Confusing Onset of MOGAD in the Form of Focal Seizures.
MOGAD is a demyelinating syndrome with the presence of antibodies against myelin oligodendrocyte glycoprotein, which is, next to multiple sclerosis and the neuromyelitis optica spectrum, one of the manifestations of the demyelinating process, more common in the pediatric population. MOGAD can take a variety of clinical forms: acute disseminated encephalomyelitis (ADEM), retrobulbar optic neuritis, often binocular (ON), transverse myelitis (TM), or NMOSD-like course (neuromyelitis optica spectrum disorders), less often encephalopathy. The course may be monophasic (40-50%) or polyphasic (50-60%), especially with persistently positive anti-MOG antibodies. Very rarely, the first manifestation of the disease, preceding the typical symptoms of MOGAD by 8 to 48 months, is focal seizures with secondary generalization, without typical demyelinating changes on MRI of the head. The paper presents a case of a 17-year-old patient whose first symptoms of MOGAD were focal epileptic seizures in the form of turning the head to the right with the elevation of the left upper limb and salivation. Seizures occurred after surgical excision of a tumor of the right adrenal gland (ganglioneuroblastoma). Then, despite a normal MRI of the head and the exclusion of onconeural antibodies in the serum and cerebrospinal fluid after intravenous treatment, a paraneoplastic syndrome was suspected. After intravenous steroid treatment and immunoglobulins, eight plasmapheresis treatments, and the initiation of antiepileptic treatment, the seizures disappeared, and no other neurological symptoms occurred for nine months. Only subsequent relapses of the disease with typical radiological and clinical picture (ADEM, MDEM, recurrent ON) allowed for proper diagnosis and treatment of the patient both during relapses and by initiating supportive treatment. The patient's case allows us to analyze the multi-phase, clinically diverse course of MOGAD and, above all, indicates the need to expand the diagnosis of epilepsy towards demyelinating diseases: determination of anti-MOG and anti-AQP4 antibodies.
Publicações recentes
Mast cell mediators in hereditary angioedema.
Prenatal Molecular Diagnosis of COL2A1-Associated Stickler Syndrome: Genotype-Phenotype Correlation in a Resource-Limited Healthcare Setting.
🥉 Relato de casoPlatelet gene signatures detecting pulmonary artery stenosis in patients with pulmonary hypertension.
The global impact of imiglucerase therapy in children with Gaucher disease types 1 and 3: a real-world analysis from the International Collaborative Gaucher Group Gaucher Registry.
Monogenic lupus with SLC7A7 mutations: a retrospective study from a Chinese center.
📚 EuropePMCmostrando 123
Overlapping autoimmunity and demyelination syndromes associated with TNF inhibitor therapy.
Clinical rheumatologyMultifocal Presentations of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): A Case Series From a District General Hospital in South East England.
CureusDouble-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.
BMC neurology[Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD): What controversies remain?].
MedicinaUncommon alliance between MOGAD and Behçet's disease.
Oxford medical case reportsHydrocephalus as an Initial Presentation of Myelin Oligodendrocyte Glycoprotein (MOG) Antibody-Associated Disease: A Case Report and Review of Tumor-Mimicking Demyelination.
CureusAnti-MOG Antibody Associated Disorders in Pakistan.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSPPaediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD): A Case Report With Varied Clinical Manifestations.
CureusFrench guidelines for the diagnosis and management of MOG antibody-associated disease.
Revue neurologiqueImpact of Anti-MOG Antibody in Diagnosis of Autoimmune Diseases of the Central Nervous System in Children: A Case Series.
NeuropediatricsCoronavirus Disease 2019 Infection and Vaccination in Pediatric Demyelinating Diseases.
Pediatric neurologyClinico-investigational profile, relapse predictors and outcomes of pediatric patients with anti-myelin oligodendrocyte associated disorders: An experience from tertiary centre.
Multiple sclerosis and related disordersConfusing Onset of MOGAD in the Form of Focal Seizures.
Neurology internationalPseudotumoural optic neuritis in myelin oligodendrocyte glycoprotein antibody-associated disease in children: Pseudotumoural optic neuritis in MOG antibody-associated disease.
Archives de pediatrie : organe officiel de la Societe francaise de pediatrieClinical characteristics of anti-myelin oligodendrocyte glycoprotein antibody among aquaporin-4 negative neuromyelitis optica spectrum disorders in Egyptian patients.
Scientific reportsNew-Onset Multiple Sclerosis in Pregnancy: Diagnostic Approaches and Treatment Dilemmas.
CureusPolyautoimmunity and multiple autoimmune syndrome in patients with neuromyelitis optica spectrum disorder.
Multiple sclerosis and related disordersA rare case of systemic lupus erythematosus-associated neuromyelitis optica spectrum disorder with cystic lesions and dual seropositivity for anti-AQP4 and anti-MOG antibodies.
Clinical case reportsIndirect Immunofluorescence-Aided Detection of Antimyelin Oligodendrocyte Glycoprotein Antibodies in Neuromyelitis Optica Spectrum Disorder/Myelin Oligodendrocyte Glycoprotein-Associated Antibody Disorder: A Case Series Involving Five Patients.
Annals of African medicineMOG CNS Autoimmunity and MOGAD.
Neurology(R) neuroimmunology & neuroinflammationExtremely Longitudinally Extensive Transverse Myelitis in a Patient With Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease.
CureusClinical, Demographic, and Radiological Characteristics of Patients Demonstrating Antibodies Against Myelin Oligodendrocyte Glycoprotein.
Balkan medical journal[Anti-MOG associated disease].
Revue medicale suisseClinical Research into Central Nervous System Inflammatory Demyelinating Diseases Related to COVID-19 Vaccines.
Diseases (Basel, Switzerland)An aggressive form of MOGAD treated with aHSCT: A case report.
Multiple sclerosis (Houndmills, Basingstoke, England)Clinical spectrum of myelin oligodendrocyte glycoprotein antibody-associated disease in Brazil: a single-center experience.
Arquivos de neuro-psiquiatriaUnderstanding MOG antibody-associated disease in Brazil.
Arquivos de neuro-psiquiatriaDual positivity for anti-MOG and oligoclonal bands: Unveiling unique clinical profiles and implications.
Multiple sclerosis and related disordersAssociation of Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease with Coronavirus Disease 2019 Vaccination and Infection: A Case Report of Cortical Encephalitis and Transverse Myelitis Relapse.
Internal medicine (Tokyo, Japan)Pathogenesis, Clinical Features, and Treatment of Patients with Myelin Oligodendrocyte Glycoprotein (MOG) Autoantibody-Associated Disorders Focusing on Optic Neuritis with Consideration of Autoantibody-Binding Sites: A Review.
International journal of molecular sciencesClinical course, imaging, and pathological features of 45 adult and pediatric cases of myelin oligodendrocyte glycoprotein antibody-associated disease.
Multiple sclerosis and related disordersEstablishment of a comprehensive diagnostic model for neuromyelitis optica spectrum disorders based on the analysis of laboratory indicators and clinical data.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyA comparative analysis of demographic, clinical and imaging features of myelin oligodendrocyte glycoprotein antibody positive, aquaporin 4 antibody positive, and double seronegative demyelinating disorders - An Indian tertiary care center prospective study.
Journal of neurosciences in rural practiceClinical and radiological profile of neuromyelitis optica spectrum disorders in a Pakistani cohort.
Multiple sclerosis and related disordersCase report: A case of acute disseminated encephalomyelitis after SARS-CoV-2 infection in pediatric patients.
Frontiers in neurologyAnti-myelin Oligodendrocyte Glycoprotein Antibody-positive Myelitis after Coronavirus Disease 2019.
Internal medicine (Tokyo, Japan)Myelin oligodendrocyte glycoprotein antibody-associated disease in children: Are there MRI predictors of relapse?
Journal of neuroradiology = Journal de neuroradiologieTransverse myelitis following COVID-19: Insights from a multi-center study and systematic literature review.
Journal of the neurological sciencesThe Prevalence, Demographics, Clinical Features, Neuroimaging, and Inter-ethnic Differences of MOGAD in Malaysia with Global Perspectives.
Multiple sclerosis and related disordersNeuromyelitis optica spectrum disorder with negative aquaporin-4 antibodies and positive anti-myelin oligodendrocyte glycoprotein antibodies: A case report.
Medical journal, Armed Forces IndiaRe-examining the characteristics of pediatric multiple sclerosis in the era of antibody-associated demyelinating syndromes.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology SocietyMyelin Oligodendrocyte Glycoprotein-Associated Disorders.
Continuum (Minneapolis, Minn.)COVID-19 Vaccine-A Potential Trigger for MOGAD Transverse Myelitis in a Teenager-A Case Report and a Review of the Literature.
Children (Basel, Switzerland)Late onset neuromyelitis optica spectrum disorders (LONMOSD) from a nationwide Portuguese study: Anti-AQP4 positive, anti-MOG positive and seronegative subgroups.
Multiple sclerosis and related disordersOptic Neuritis in the Era of NMOSD and MOGAD: A Survey of Practice Patterns in Singapore.
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)Follow-up of retinal thickness and optic MRI after optic neuritis in anti-MOG antibody-associated disease and anti-AQP4 antibody-positive NMOSD.
Journal of the neurological sciencesNeuromyelitis Optica Spectrum Disorder in Central America and the Caribbean: A Multinational Clinical Characterization Study.
Neurology internationalFailure of alemtuzumab therapy in three patients with MOG antibody associated disease.
BMC neurologyTreatment regimens for neuromyelitis optica spectrum disorder attacks: a retrospective cohort study.
Journal of neuroinflammationPediatric neuromyelitis optica spectrum disorders in Portugal: A multicentre retrospective study.
Multiple sclerosis and related disordersFive-year visual outcomes after optic neuritis in anti-MOG antibody-associated disease.
Multiple sclerosis and related disordersApplication of deep-learning to the seronegative side of the NMO spectrum.
Journal of neurologyConus medullaris involvement in demyelinating disorders of the CNS: A comparative study.
Multiple sclerosis and related disordersAseptic meningitis and leptomeningeal enhancement associated with anti-MOG antibodies: A review.
Journal of neuroimmunology[Anti-Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease].
Brain and nerve = Shinkei kenkyu no shinpoNo strong HLA association with MOG antibody disease in the UK population.
Annals of clinical and translational neurologyDifference in the Source of Anti-AQP4-IgG and Anti-MOG-IgG Antibodies in CSF in Patients With Neuromyelitis Optica Spectrum Disorder.
NeurologyHemicraniectomy and externalized ventricular drain placement in a pediatric patient with myelin oligodendrocyte glycoprotein-associated tumefactive demyelinating disease.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryProgressive Leukodystrophy-Like Demyelinating Syndromes with MOG-Antibodies in Children: A Rare Under-Recognized Phenotype.
NeuropediatricsMeningitis as a recurrent manifestation of anti-AQP4/anti-MOG negative neuromyelitis optica spectrum disorder: a case report.
BMC neurologyThe efficacy of rituximab in patients with neuromyelitis optica spectrum disorder: A real-world study from Turkey.
International journal of clinical practiceCase Report: Anti-MOG Antibody Seroconversion Accompanied by Dimethyl Fumarate Treatment.
Frontiers in immunologyAnti-MOG associated disorder-Clinical and radiological characteristics compared to AQP4-IgG+ NMOSD-A single-center experience.
Multiple sclerosis and related disordersMOG-IgG-associated disorder and systemic lupus erythematosus disease: Systematic review.
LupusAtypical Multiple Sclerosis with Antibody to MOG.
Neurology IndiaClinical outcomes of transverse myelitis with myelin oligodendrocyte glycoprotein antibody versus negative cases among adults in Isfahan, Iran: A comparative study.
Current journal of neurology[Clinical presentation of the spectrum of myelin oligodendocryte glycoprotein antibody disease].
Revista de neurologiaAn update on epidemiology, diagnosis & management of NMO-SD in the tertiary neurology department of Marrakech (Morocco).
Revue neurologique[Atypical optic neuritis: the importance of a comprehensive diagnostic work-up].
Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen GesellschaftAnti-MOG and Anti-AQP4 positive neuromyelitis optica spectrum disorder in a patient with myasthenia gravis.
Multiple sclerosis and related disordersCase Series: Myelin Oligodendrocyte Glycoprotein-Immunoglobulin G-Related Disease Spectrum.
Frontiers in neurology[Anti-myelin oligodendrocyte glycoprotein antibody-positive neurologic disease, manifested as clinical course of classical Devic's disease: A case report].
Rinsho shinkeigaku = Clinical neurologyAssociations of paediatric demyelinating and encephalitic syndromes with myelin oligodendrocyte glycoprotein antibodies: a multicentre observational study.
The Lancet. NeurologyUse of ganglion cell layer analysis for diagnosing anti-glycoprotein neuromyelitis optica of oligodendrocyte myelin.
Archivos de la Sociedad Espanola de OftalmologiaDeciphering anti-MOG IgG antibodies: Clinical and radiological spectrum, and comparison of antibody detection assays.
Journal of the neurological sciencesNeuromyelitis Optica Spectrum Disorder and Anti-Aquaporin 4 Channel Immunoglobulin in an Australian Pediatric Demyelination Cohort.
Journal of child neurology[Optic neuropathy in positive anti-MOG antibody syndrome].
Journal francais d'ophtalmologieCNS inflammatory demyelinating disorders: MS, NMOSD and MOG antibody associated disease.
Journal of investigative medicine : the official publication of the American Federation for Clinical ResearchSerial Anti-Myelin Oligodendrocyte Glycoprotein Antibody Analyses and Outcomes in Children With Demyelinating Syndromes.
JAMA neurologyClinical and radiologic approach to 'typical' versus antibody-related optic neuritis.
Current opinion in ophthalmologyThe accuracy of flow cytometric cell-based assay to detect anti-myelin oligodendrocyte glycoprotein (MOG) antibodies determining the optimal method for positivity judgement.
Journal of neuroimmunologyIncidence of pediatric neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease in Denmark 2008‒2018: A nationwide, population-based cohort study.
Multiple sclerosis and related disordersNeuromyelitis Optica Spectrum Disorder and Anti-MOG Syndromes.
BiomedicinesThe clinical spectrum of anti-MOG associated acquired demyelinating disorders: Three case-reports.
Multiple sclerosis and related disorders[Longitudinally extensive transverse myelitis involving fifteen vertebral bodies positive for anti-myelin oligodendrocyte glycoprotein (MOG) antibody: a case report].
Rinsho shinkeigaku = Clinical neurologySuccessful intravenous immunoglobulin treatment in relapsing MOG-antibody-associated disease.
Multiple sclerosis and related disordersMOG antibody-associated encephalomyelitis/encephalitis.
Multiple sclerosis (Houndmills, Basingstoke, England)Isolated recurrent myelitis in a persistent MOG positive patient.
Multiple sclerosis and related disordersAntibody-mediated biorecognition of myelin oligodendrocyte glycoprotein: computational evidence of demyelination-related epitopes.
Scientific reportsLive-cell based assays are the gold standard for anti-MOG-Ab testing.
NeurologyNeuromyelitis optica spectrum disorder: Pathogenesis, treatment, and experimental models.
Multiple sclerosis and related disordersClinical characteristics of 153 Brazilian patients with neuromyelitis optica spectrum disorder (NMOSD).
Multiple sclerosis and related disordersPositive anti-MOG antibodies in a patient with Sjögren's syndrome and transverse myelitis.
European journal of rheumatologyComparing myelin oligodendrocyte glycoprotein antibody (MOG-Ab) and non MOG-Ab associated optic neuritis: Clinical course and treatment outcome.
Multiple sclerosis and related disordersInflammatory demyelinating diseases of the central nervous system in Niger.
Revue neurologiqueClinical utility of anti-MOG antibody testing in a Danish cohort.
Multiple sclerosis and related disordersNMOSD with anti-MOG antibodies following anti-TNFα therapy: A case report.
Multiple sclerosis and related disordersRetrospective analysis of children with myelin oligodendrocyte glycoprotein antibody-related disorders.
Multiple sclerosis and related disordersAnti-Myelin Oligodendrocyte Glycoprotein Antibody Associated With Gray Matter Predominant Transverse Myelitis Mimicking Acute Flaccid Myelitis: A Presentation of Two Cases.
Pediatric neurologyA case of anti-MOG antibody-positive unilaterally dominant meningoencephalitis followed by longitudinally extensive transverse myelitis.
Multiple sclerosis and related disordersMOG-IgG-associated disease has a stereotypical clinical course, asymptomatic visual impairment and good treatment response.
Multiple sclerosis journal - experimental, translational and clinicalLate-onset neutropenia and neurological relapse, during long-term rituximab therapy in myelin oligodendrocyte glycoprotein-antibody spectrum disorder.
Multiple sclerosis (Houndmills, Basingstoke, England)[Autoantibodies in Neuromyelitis Optica Spectrum Disorders].
Brain and nerve = Shinkei kenkyu no shinpo[Anti-MOG Antibody Associated Diseases].
Brain and nerve = Shinkei kenkyu no shinpoSubclinical retinal atrophy in the unaffected fellow eyes of multiple sclerosis and neuromyelitis optica.
Journal of neuroimmunologyReversible paraspinal muscle hyperintensity in anti-MOG antibody-associated transverse myelitis.
Neurology(R) neuroimmunology & neuroinflammationUnderstanding the Antibody Repertoire in Neuropsychiatric Systemic Lupus Erythematosus and Neuromyelitis Optica Spectrum Disorder: Do They Share Common Targets?
Arthritis & rheumatology (Hoboken, N.J.)[Anti-myelin oligodendrocyte glycoprotein (MOG) antibody-positive varicella-zoster virus myelitis presenting as longitudinally extensive transverse myelitis: a case report].
Rinsho shinkeigaku = Clinical neurology[Neuromyelitis optica with anti-MOG antibodies: A case report].
Journal francais d'ophtalmologieRelapsing optic neuritis and isolated transverse myelitis are the predominant clinical phenotypes for patients with antibodies to myelin oligodendrocyte glycoprotein in India.
Multiple sclerosis journal - experimental, translational and clinical[An asynchronous bilateral optic neuropathy with positive MOG antibodies].
Journal francais d'ophtalmologieAnti-MOG antibody-positive ADEM following infectious mononucleosis due to a primary EBV infection: a case report.
BMC neurologySerological markers associated with neuromyelitis optica spectrum disorders in South India.
Annals of Indian Academy of Neurology[Anti-MOG + neuromyelitis optica spectrum disorders treated with plasmapheresis].
No to hattatsu = Brain and developmentLesion length of optic neuritis impacts visual prognosis in neuromyelitis optica.
Journal of neuroimmunologyMyelin-reactive antibodies initiate T cell-mediated CNS autoimmune disease by opsonization of endogenous antigen.
Acta neuropathologicaAutoantibody to MOG suggests two distinct clinical subtypes of NMOSD.
Science China. Life sciencesAnti-MOG antibody: The history, clinical phenotype, and pathogenicity of a serum biomarker for demyelination.
Autoimmunity reviewsChange in autoantibody and cytokine responses during the evolution of neuromyelitis optica in patients with systemic lupus erythematosus: A preliminary study.
Multiple sclerosis (Houndmills, Basingstoke, England)The clinical spectrum associated with myelin oligodendrocyte glycoprotein antibodies (anti-MOG-Ab) in Thai patients.
Multiple sclerosis (Houndmills, Basingstoke, England)Anti-MOG antibodies with longitudinally extensive transverse myelitis preceded by CLIPPERS.
NeurologyAnti-MOG antibodies are present in a subgroup of patients with a neuromyelitis optica phenotype.
Journal of neuroinflammationAnti-MOG antibodies plead against MS diagnosis in an Acquired Demyelinating Syndromes cohort.
Multiple sclerosis (Houndmills, Basingstoke, England)Associações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Mielite transversa aguda com anticorpos anti-MOG.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Mielite transversa aguda com anticorpos anti-MOG
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Ainda não achamos doenças com sintomas parecidos o suficiente.
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Overlapping autoimmunity and demyelination syndromes associated with TNF inhibitor therapy.
- Double-negative NMOSD: from case report to a proposed diagnostic and therapeutic algorithm.
- Impact of Anti-MOG Antibody in Diagnosis of Autoimmune Diseases of the Central Nervous System in Children: A Case Series.
- Coronavirus Disease 2019 Infection and Vaccination in Pediatric Demyelinating Diseases.
- Confusing Onset of MOGAD in the Form of Focal Seizures.
- Mast cell mediators in hereditary angioedema.
- Prenatal Molecular Diagnosis of COL2A1-Associated Stickler Syndrome: Genotype-Phenotype Correlation in a Resource-Limited Healthcare Setting.
- Platelet gene signatures detecting pulmonary artery stenosis in patients with pulmonary hypertension.
- The global impact of imiglucerase therapy in children with Gaucher disease types 1 and 3: a real-world analysis from the International Collaborative Gaucher Group Gaucher Registry.
- Monogenic lupus with SLC7A7 mutations: a retrospective study from a Chinese center.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:592873(Orphanet)
- MONDO:0035666(MONDO)
- GARD:22375(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
