Introdução
O que você precisa saber de cara
Fechamento prematuro da sutura coronal e esfenoidal em um lado do crânio, afetando o desenvolvimento facial e cerebral. Geralmente sem outras anomalias associadas.
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<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
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Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Craniossinostose unifrontoesfenoidal não-sindrômica
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Publicações mais relevantes
Low-cost beetle-wing fronto-orbital advancement using nonabsorbable suture fixation for non-syndromic trigonocephaly: A single center experience.
Trigonocephaly results from premature fusion of the metopic suture, leading to restricted frontal bone growth and a triangular forehead. Its incidence has increased, and fronto-orbital advancement (FOA) with frontal remodeling is now the standard surgical treatment, However, the use of absorbable fixation system may increase costs and limit accessibility. This study evaluates the aesthetic and functional outcomes of a modified Dhellemmes (Lille) beetle-wing FOA using nonabsorbable sutures as a low-cost alternative for nonsyndromic trigonocephaly. Twenty-four patients aged 6-12 months with nonsyndromic trigonocephaly treated at the Hospital Universitario "Dr. José Eleuterio Gonzalez" between 2019 and 2022 were included. Parental satisfaction regarding aesthetic and functional outcomes was assessed through telephone interviews using a four-point scale (very satisfied: 4; satisfied: 3; slightly satisfied: 2; completely dissatisfied: 1). The study included 15 (62.5%) males and 9 (37.5%) females who underwent bettle-wing FOA at a mean age of 9.2 months. Postoperative evaluation using a structured parent-reported questionnaire demonstrated high aesthetic and functional satisfaction. A significant correlation was observed between aesthetic and functional outcomes (Spearman's ρ = 0.622 and 0.924, respectively; p = 0.05). No intraoperative or postoperative complications were reported. The modified surgical technique using nonabsorbable sutures such as Silk or 3-0 Prolene provides a safe, effective, and affordable alternative for the correction of trigonocephaly in infants. It yields aesthetic and functional outcomes while potentially lowering overall surgical costs, thereby improving accessibility in resource-limited settings.
Fibronectin 1 is required for suture patency and dysregulated across craniosynostosis models in the mouse.
The mammalian skull roof is comprised of calvarial bones, connected through fibrous sutures, that protect the brain and allow for growth. Premature suture closure, or craniosynostosis (CS), impedes expansion, impacting 1 in every 2500 newborns. Despite its genetic heterogeneity, with nearly 80 associated genes, CS manifests as a common phenotype, hinting at a convergent etiological mechanism. Recently, we described how graded expression of extracellular matrix protein Fibronectin (FN1) is required for apical expansion of calvaria and coronal suture patency. Dysregulated FN1 expression has been identified in two human CS syndromes, suggesting its potential as a convergent mechanism of CS. Here, we further investigate the cellular basis for the CS phenotype in the Fn1 mutant mouse. Graded expression of FN1 baso-apically in the cranial mesenchyme was variably dysregulated across mouse models of syndromic and non-syndromic CS and accompanied by diminished apical expansion of frontal bone primordia. In parallel, at later developmental stages we find ectopic osteogenic induction of Six2 + patent suture mesenchyme in the Fn1 mutant. These findings pinpoint FN1 as a crucial regulator of suture patency by modulating calvarial growth and driving cell identity, and differentiation, thus providing a potential target for matrix-mediated treatments.
Daily executive function in children and adolescents with non-syndromic craniosynostosis: association with timing of surgical intervention.
This study aimed to assess executive functioning in everyday activities of participants with non-syndromic craniosynostosis, to compare their performance with a control group, to assess the relationship between the timing of surgery and executive functioning, and to determine the proportion of participants scoring in the clinical range for executive functions. Twenty-nine participants with craniosynostosis and 30 controls were assessed with the parent version of the Behavior Rating Inventory of Executive Function 2 (BRIEF-2). Both groups scored similarly. However, the older the participant with craniosynostosis at the time of the surgery, the greater their difficulties in Task Initiation, Working Memory, Planning, and Monitoring. Only a small percentage (0-17%) of participants with craniosynostosis scored in the clinically significant range; this proportion was similar to that of the control group. This study did not find substantial difficulties in executive functions in daily activities in participants with non-syndromic craniosynostosis, but it did find an association between late surgery and lower scores in some cold executive functions. The study suggests that early surgical intervention could have a potential neurodevelopmental benefit for children and adolescents with craniosynostosis.
Feasibility and reproducibility of handheld and table-mounted optical coherence tomography in children with craniosynostosis.
Optical coherence tomography (OCT) can be a valuable tool for non-invasively monitoring the optic nerve status in children with craniosynostosis. However, it is currently unknown whether optic nerve parameters derived from handheld OCT are comparable to those derived from table-mounted OCT, which is more widely used. This study aims to assess the feasibility and reproducibility of handheld and table-mounted OCT in craniosynostosis. This was a cross-sectional study conducted at Great Ormond Street Hospital (GOSH), London. Twenty children aged 4-18 years with a clinical/genetic diagnosis of craniosynostosis were included. Bilateral optic nerve head OCT imaging was performed using the Spectralis (Heidelberg Engineering), followed by the handheld Envisu C2300 (Leica Microsystems). Primary outcome measures were quantitative cup, disc, rim and peripapillary parameters. Intraclass correlation coefficients (ICC) and coefficient of variation (CoV) were calculated for each quantitative OCT parameter. 20 children (100%) were successfully recruited. Median age at the time of OCT examination was 6 years (range: 4-16; IQR: 5-8). Ten participants (50%) were female. Seven participants (35%) had syndromic craniosynostosis and 13 participants (65%) had non-syndromic craniosynostosis. Bilateral imaging success was 100% for both machines. ICCs were good-to-excellent for all parameters, ranging from 0.81 to 1.00. The coefficient of variation was low for all parameters. OCT imaging of the optic nerve is feasible in school-aged children with craniosynostosis and comparable between the Spectralis and handheld Envisu OCT. This could allow comparison and pooling of data between the two machines, greatly enhancing patient care and future research.
Incidence of Ocular Abnormalities in Metopic Craniosynostosis: Cranial Vault Reconstruction Versus Endoscopic Suturectomy.
ObjectiveTo compare the incidence of ocular abnormalities in patients with metopic craniosynostosis (MCS) treated with cranial vault reconstruction (CVR) versus endoscopic suturectomy (ESC).DesignRetrospective cohort study using the TriNetX Research Network.SettingMulti-institutional electronic health record database.Patients, ParticipantsA total of 588 pediatric patients with non-syndromic MCS (441 CVR, 147 ESC) were identified by ICD-10 and CPT codes. Propensity score matching and age adjustment were performed to reduce confounding.InterventionsSubjects underwent either CVR or ESC. Ocular and surgical complication outcomes were assessed.Main Outcome Measure(s)Primary outcome is ocular abnormalities. Secondary outcomes include surgical complications and reoperations.ResultsOcular abnormalities were present in 40.31% of MCS patients. CVR was associated with a significantly higher incidence compared to ESC (44.67% vs 27.21%; RR = 1.64; 95% CI: 1.23-2.18). CVR patients had greater rates of strabismus (15.19% vs 7.48%; RR = 2.03; 95% CI: 1.10-3.74), ametropia (29.71% vs 11.56%; RR = 2.57; 95% CI: 1.58-4.20), and astigmatism (15.87% vs 2.72%; RR = 5.84; 95% CI: 2.17-15.70). These differences remained significant after adjusting for age and matching by sex, race, and ethnicity. The ESC group showed ocular outcomes comparable to the general pediatric population.ConclusionsPatients with metopic craniosynostosis have a high rate of ocular abnormalities, and there may be a difference between those who undergo CVR versus ESC. These findings underscore the need for routine ophthalmologic surveillance and future prospective studies are needed to confirm the findings.
Publicações recentes
Daily executive function in children and adolescents with non-syndromic craniosynostosis: association with timing of surgical intervention.
Low-cost beetle-wing fronto-orbital advancement using nonabsorbable suture fixation for non-syndromic trigonocephaly: A single center experience.
Concurrent posterior vault expansion and extradural Chiari decompression in syndromic and non-syndromic craniosynostosis: a case series.
Partial intracranial volumes in metopic synostosis - pre- and postoperative comparisons with healthy controls.
Evaluation of long-term aesthetic outcomes of fronto-orbital advancement using a crossing-the-midline greenstick fracture technique in anterior synostotic plagiocephaly.
📚 EuropePMCmostrando 199
Fibronectin 1 is required for suture patency and dysregulated across craniosynostosis models in the mouse.
bioRxiv : the preprint server for biologyDaily executive function in children and adolescents with non-syndromic craniosynostosis: association with timing of surgical intervention.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryFeasibility and reproducibility of handheld and table-mounted optical coherence tomography in children with craniosynostosis.
Eye (London, England)Low-cost beetle-wing fronto-orbital advancement using nonabsorbable suture fixation for non-syndromic trigonocephaly: A single center experience.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaIncidence of Ocular Abnormalities in Metopic Craniosynostosis: Cranial Vault Reconstruction Versus Endoscopic Suturectomy.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationConcurrent posterior vault expansion and extradural Chiari decompression in syndromic and non-syndromic craniosynostosis: a case series.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryExamining Sociodemographic Disparities in Diagnostic Delays and Surgical Management of Non-Syndromic Craniosynostosis: A 10-Year Review.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationShunt Complications in Syndromic versus Non-Syndromic Pediatric Hydrocephalus: A Propensity-Matched Multicenter Analysis of 35,234 Patients.
Pediatric neurosurgeryPartial intracranial volumes in metopic synostosis - pre- and postoperative comparisons with healthy controls.
Journal of plastic surgery and hand surgeryEvaluation of long-term aesthetic outcomes of fronto-orbital advancement using a crossing-the-midline greenstick fracture technique in anterior synostotic plagiocephaly.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryLong-term outcome in 415 operated cases with single suture scaphocephaly.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryLong-term health-related quality of life and satisfaction following fronto-orbital advancement in non-syndromic metopic synostosis: FACE-Q Craniofacial Module and SCAR-Q.
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Molecular genetics & genomic medicinePsychosocial Support for Australian Families Impacted by Craniosynostosis: A Qualitative Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationIntraoperative Lactate Level as a Predictor of Resuscitation in Open Cranial Vault Reconstruction.
The Journal of craniofacial surgeryNon-syndromic craniosynostosis.
Nature reviews. Disease primersPreliminary quantitative assessment of surgical outcomes in Craniosynostosis correction procedures: A 3D-Morphometric comparison.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryThe Efficacy of Postoperative Helmet Therapy After Open Cranial Vault Remodeling for Nonsyndromic Craniosynostosis.
The Journal of craniofacial surgeryNovel digital measurement system for predicting surgical outcomes in patients with primary non-syndromic craniosynostosis.
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Journal of plastic surgery and hand surgeryA morphometric analysis of the cranial base in trigonocephaly.
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The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationComparison of syndromic and non-syndromic craniosynostosis cases followed in a tertiary pediatric intensive care unit: a case control study.
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Journal francais d'ophtalmologieEvaluating mechanical benefit of wedge osteotomies in endoscopic surgery for sagittal synostosis using patient-specific 3D-printed models.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryAI-based diagnosis and phenotype - Genotype correlations in syndromic craniosynostoses.
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Medicina (Kaunas, Lithuania)Brain volume in infants with metopic synostosis: Less white matter volume with an accelerated growth pattern in early life.
Journal of anatomyPrevalence of craniosynostosis in Finland, 1987-2010: A population-based study.
Birth defects research[Prospective analysis of inflammatory markers and perioperative clinical data in children with craniosynostosis undergoing reconstructive surgery].
Zhurnal voprosy neirokhirurgii imeni N. N. BurdenkoEvaluation of neurocognitive and social developments after craniosynostosis surgery.
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CureusPrenatal diagnostic approaches diagnosed craniosynostosis and identified a novel nonsense variant in SMAD6 in a Chinese fetus.
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European journal of obstetrics, gynecology, and reproductive biologyPatient-reported outcome measures more than fifteen years after treatment of sagittal or metopic craniosynostosis: a prospective cohort study.
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European journal of medical geneticsOxycephaly-systematic review, case presentation, and diagnostic clarification.
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Frontiers in pediatricsThe biomechanics of chewing and suckling in the infant: A potential mechanism for physiologic metopic suture closure.
PLoS computational biology[Evaluation of the clinical efficacy of minimally invasive endoscopic surgery in the treatment of isolated non-syndromic sagittal synostosis in infants].
Zhonghua yi xue za zhiEarly bone reformation after cranial vault remodelling for sagittal craniosynostosis: A retrospective 3D analysis.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryPostoperative computed tomography imaging of pediatric patients with craniosynostosis: radiation dose and image quality comparison between multi-slice computed tomography and O-arm cone-beam computed tomography.
Pediatric radiologyLong-term neurocognitive outcomes in 204 single-suture craniosynostosis patients.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryCognitive performance in preschoolers with non-syndromic craniosynostosis undergoing surgery: A comparison with typically developing children.
Applied neuropsychology. ChildLong-term aesthetic and photogrammetric outcomes in non-syndromic unicoronal synostosis: comparison of fronto-orbital distraction osteogenesis and fronto-orbital advancement and remodeling.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryPractical Algorithm for the Management of Multisutural Craniosynostosis with Associated Chiari Malformation and/or Hydrocephalus.
Pediatric neurosurgeryDental management of a pediatric patient with progressive familial intrahepatic cholestasis having dental anomalies: a case report and brief review of the literature.
BMC oral healthMolecular Mechanisms Involved in Craniosynostosis.
In vivo (Athens, Greece)Sex Differences in Comorbidities of Pediatric Craniosynostosis at Presentation.
Pediatric neurosurgeryRetroperitoneal liposarcoma and craniosynostosis: possible genomic relationship, case report, and literature review.
Functional & integrative genomicsHealth-related quality of life of children treated for non-syndromic craniosynostosis.
Journal of plastic surgery and hand surgeryThe current understanding of germline predisposition in non-syndromic sagittal craniosynostosis: a systematic review.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgerySpring forces and calvarial thickness predict cephalic index changes following spring-mediated cranioplasty for sagittal craniosynostosis.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryPosterior cranial vault distraction osteogenesis: A systematic review.
Journal of oral biology and craniofacial researchAesthetic results in children with single suture craniosynostosis: proposal for a modified Whitaker classification.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryAssessing Long-Term Neurodevelopment among Children with Non-Syndromic Single Suture Craniosynostosis.
World journal of plastic surgeryThe foramen magnum in scaphocephaly.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryMultidisciplinary Care Considerations for Patients with Craniosynostosis.
Oral and maxillofacial surgery clinics of North AmericaAppearance or attitude: what matters to craniosynostosis patients? Association of self-esteem, depressive symptoms, and facial aesthetics in patients with sagittal and metopic synostosis.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryTargeted Sequencing of Candidate Regions Associated with Sagittal and Metopic Nonsyndromic Craniosynostosis.
GenesLong-term ophthalmological outcomes in patients with anterior plagiocephaly managed with a fronto-orbital advancement procedure.
Journal francais d'ophtalmologieUtility of Preoperative Helmet Molding Therapy in Patients With Isolated Sagittal Craniosynostosis.
The Journal of craniofacial surgeryEndoscopic treatment of sagittal suture synostosis - a critical analysis of current management strategies.
Neurosurgical reviewAssociation between craniofacial anomalies, intellectual disability and autism spectrum disorder: Western Australian population-based study.
Pediatric researchHigh risk factors for craniosynostosis during pregnancy: A case-control study.
European journal of obstetrics & gynecology and reproductive biology: XPolycystin-1 regulates cell proliferation and migration through AKT/mTORC2 pathway in a human craniosynostosis cell model.
Journal of cellular and molecular medicineApplication of Deep Learning Techniques for Automated Diagnosis of Non-Syndromic Craniosynostosis Using Skull.
The Journal of craniofacial surgeryPrevalence of Ocular Anomalies in Craniosynostosis: A Systematic Review and Meta-Analysis.
Journal of clinical medicineNeurocognitive outcomes of children with non-syndromic single-suture craniosynostosis.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryOphthalmological findings in children with unicoronal craniosynostosis.
European journal of ophthalmologyParental Satisfaction from Telemedicine in the Follow-up of Children Operated for Craniosynostosis during COVID-19 Pandemic.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationIncidence of Non-Syndromic and Syndromic Craniosynostosis in Sweden.
The Journal of craniofacial surgeryCraniofacial Dysmorphology in Infants With Non-Syndromic Unilateral Coronal Craniosynostosis.
The Journal of craniofacial surgeryThe use of a single-piece bone flap for cranial reshaping in anterior craniosynostosis patients: clinical experience and a description of a novel technique.
Maxillofacial plastic and reconstructive surgeryPsychological and Physical Health Outcomes in Adults With Craniosynostosis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationAnterior fontanelle closure and diagnosis of non-syndromic craniosynostosis: a comparative study using computed tomography.
Jornal de pediatriaSyndromic Craniosynostosis: Objective and Parent-Reported Outcome Measurements after Cranio-Facial Remodelling Surgeries.
Pediatric neurosurgeryAntifibrinolytics Are Not Associated With Reduced Blood Loss in Minimally-Invasive Endoscopic-Assisted Craniectomy for Repair of Single-Suture Craniosynostosis.
The Journal of craniofacial surgeryCraniosynostosis Surgery for Increased Intracranial Pressure.
The Journal of craniofacial surgeryLong-term Outcomes of Non-syndromic and Syndromic Craniosynostosis: Analysis of Demographic, Morphologic, and Surgical Factors.
Neurologia medico-chirurgicaDe novo ALX4 variant detected in child with non-syndromic craniosynostosis.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicasSpring-assisted posterior vault expansion-a single-centre experience of 200 cases.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryHealth-related quality of life in children after surgical treatment of non-syndromal craniosynostosis.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryCiliary Signalling and Mechanotransduction in the Pathophysiology of Craniosynostosis.
GenesUsing Perfusion Contrast for Spatial Normalization of ASL MRI Images in a Pediatric Craniosynostosis Population.
Frontiers in neuroscienceFeasibility and Repeatability of Handheld Optical Coherence Tomography in Children With Craniosynostosis.
Translational vision science & technologySecondary Raised Intracranial Pressure After Cranial Vault Remodeling for Isolated Sagittal Craniosynostosis.
The Journal of craniofacial surgeryOphthalmic features of craniosynostosis: A Malaysian experience.
European journal of ophthalmologyTrigonocephaly and Cranium Bifidum Occultum Treated Simultaneously Using the Split-Bone Technique and Piezosurgery.
CureusOphthalmological findings in children with non-syndromic craniosynostosis: preoperatively and postoperatively up to 12 months after surgery.
BMJ open ophthalmologyNew method for quantification of the relative severity and (a)symmetry of isolated metopic synostosis.
International journal of oral and maxillofacial surgeryPosterior vault distraction osteogenesis: indications and expectations.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryOcular biometric features of pediatric patients with fibroblast growth factor receptor-related syndromic craniosynostosis.
Scientific reportsIdentification of differentially expressed proteins between fused and open sutures in sagittal nonsyndromic craniosynostosis during suture development by quantitative proteomic analysis.
Proteomics. Clinical applicationsNeuro-Ophthalmological Manifestations of Craniosynostosis: Current Perspectives.
Eye and brainDistinguishing craniomorphometric characteristics and severity in metopic synostosis patients.
International journal of oral and maxillofacial surgeryEmissary veins and pericerebral cerebrospinal fluid in trigonocephaly: do they define a specific subtype?
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryA Role for Artificial Intelligence in the Classification of Craniofacial Anomalies.
The Journal of craniofacial surgerySynostosis of the lambdoid suture: a spectrum.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryAdvanced parental age: Is it contributing to an increased incidence of non-syndromic craniosynostosis? A review of case-control studies.
Journal of oral biology and craniofacial researchSerum nickel is associated with craniosynostosis risk: Evidence from humans and mice.
Environment internationalComputational modelling of patient specific spring assisted lambdoid craniosynostosis correction.
Scientific reportsCraniosynostosis: To Study the Spectrum and Outcome of Surgical Intervention at a Tertiary Referral Institute in India.
Journal of pediatric neurosciencesUnderstanding families' experiences following a diagnosis of non-syndromic craniosynostosis: a qualitative study.
BMJ openSecondary Coronal Synostosis After Early Surgery for Sagittal Craniosynostosis: Implications for Cranial Growth.
The Journal of craniofacial surgerySpring-Assisted Strip Craniectomy Versus Cranial Vault Remodeling: Long-Term Psychological, Behavioral, and Executive Function Outcomes.
The Journal of craniofacial surgeryTotal Cranial Reconstruction for the Treatment of Sagittal Craniosynostosis in Children.
The Journal of craniofacial surgeryA Technique for Minimizing the Need for Hemotransfusion in Non-Syndromic Craniosynostosis Surgery.
The Journal of craniofacial surgeryTCF12 haploinsufficiency causes autosomal dominant Kallmann syndrome and reveals network-level interactions between causal loci.
Human molecular geneticsCraniosynostosis in an Indian Scenario: A Long-term Follow-up.
Plastic and reconstructive surgery. Global openSporting activity after craniosynostosis surgery in children: a source of parental anxiety.
Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery"Black bone": the new backbone in CAD/CAM-assisted craniosynostosis surgery?
Acta neurochirurgicaTiming of Ossification of the Anterior Skull Base in Syndromic Synostosis.
The Journal of craniofacial surgeryCorrelation of Intracranial Volume With Head Surface Volume in Patients With Multisutural Craniosynostosis.
The Journal of craniofacial surgeryPublic Perception of a Normal Head Shape in Children With Sagittal Craniosynostosis.
The Journal of craniofacial surgeryThe Effect of Fronto-Orbital Advancement on Frontal Sinus Development and Function in Non-Syndromic and Syndromic Craniosynostosis.
The Journal of craniofacial surgery22q11.2 deletion syndrome and congenital heart disease.
American journal of medical genetics. Part C, Seminars in medical geneticsSingle-suture craniosynostosis: is there a correlation between preoperative ophthalmological, neuroradiological, and neurocognitive findings?
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryOrbito-facial dysmorphology in patients with different degrees of trigonocephaly severity: quantitative morpho-volumetric analysis in infants with non-syndromic metopic craniosynostosis.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryBehavioral functioning of school-aged children with non-syndromic craniosynostosis.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryIncidence of delayed intracranial hypertension in children with isolated sagittal synostosis following open calvarial vault reconstruction.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryThe Influence of Epigenetic Factors in Four Pairs of Twins With Non-Syndromic Craniosynostosis.
The Journal of craniofacial surgeryBehavioral Disorders of Preschool Children With Non-Syndromic Craniosynostosis.
The Journal of craniofacial surgeryCranial growth in isolated sagittal craniosynostosis compared with normal growth in the first 6 months of age.
Journal of anatomyThe removal of cranial springs used in the treatment of scaphocephaly: A minimal access approach.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryGenetic bases of craniosynostoses: An update.
Neuro-Chirurgie[Neuropsychological consequences of craniosynostosis: Non-syndromic scaphocephaly].
Neuro-ChirurgieRecent advances in trigonocephaly.
Neuro-ChirurgieSagittal suture craniosynostosis or craniosynostoses? The heterogeneity of the most common premature fusion of the cranial sutures.
Neuro-ChirurgieWhat remains of non-syndromic bicoronal synostosis?
Neuro-ChirurgieCalvarial osteoblast gene expression in patients with craniosynostosis leads to novel polygenic mouse model.
PloS oneFollow-up study to investigate symmetry and stability of cranioplasty in craniosynostosis - Introduction of new pathology-specific parameters and a comparison to the norm population.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryChiari type I and hydrocephalus.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryRole of Autologous Fat Injection in Neglected Patients With Anterior Plagiocephaly.
The Journal of craniofacial surgeryBiallelic variants in SMAD6 are associated with a complex cardiovascular phenotype.
Human geneticsTwo novel variants in the TCF12 gene identified in cases with craniosynostosis.
The application of clinical geneticsConfirmation of the role of pathogenic SMAD6 variants in bicuspid aortic valve-related aortopathy.
European journal of human genetics : EJHGManagement of non-syndromic craniosynostoses in France in 2015: A national survey.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryNon-syndromic craniosynostosis treated by frontal orbital advancement: A case report.
The Medical journal of MalaysiaAdditional squamosal suture synostosis and segmented intracranial volume in patients with non-syndromic sagittal synostosis.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryNon-Syndromic Craniosynostosis Mimicking Primary Pseudotumor Cerebri Syndrome.
HeadachePrenatal sonographic findings and prognosis of craniosynostosis diagnosed during the fetal and neonatal periods.
Congenital anomaliesCo-occurrence of frameshift mutations in SMAD6 and TCF12 in a child with complex craniosynostosis.
Human genome variationImage based simulation of the low dose computed tomography images suggests 13 mAs 120 kV suitability for non-syndromic craniosynostosis diagnosis without iterative reconstruction algorithms.
European journal of radiologyClinical evaluation of non-syndromic scaphocephaly surgically corrected with the procedure of total vertex craniectomy.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryNon-syndromic craniosynostosis in children: Scoping review.
Medicina oral, patologia oral y cirugia bucalA Review Of Referral Patterns For Sagittal Synostosis In Ireland: 2008-2013.
Irish medical journalAn audiological evaluation of syndromic and non-syndromic craniosynostosis in pre-school going children.
International journal of pediatric otorhinolaryngologyModified Le Fort III osteotomy: A simple solution to severe midfacial hypoplasia.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryVolumetric lipoinjection of the fronto-orbital and temporal complex with adipose stem cells for the aesthetic restoration of sequelae of craniosynostosis.
Archives of plastic surgeryNon-syndromic single-suture craniosynostosis in triplets.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryReduced Intercarotid Artery Distance in Syndromic and Isolated Brachycephaly.
Pediatric neurologyFibroblast Growth Factor Receptor 2 (FGFR2) Mutation Related Syndromic Craniosynostosis.
International journal of biological sciencesHUWE1 variants cause dominant X-linked intellectual disability: a clinical study of 21 patients.
European journal of human genetics : EJHGSingle suture craniosynostosis: Identification of rare variants in genes associated with syndromic forms.
American journal of medical genetics. Part ASyndromic Craniosynostosis Can Define New Candidate Genes for Suture Development or Result from the Non-specifc Effects of Pleiotropic Genes: Rasopathies and Chromatinopathies as Examples.
Frontiers in neuroscienceLength of synostosis and segmented intracranial volume correlate with age in patients with non-syndromic sagittal synostosis.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryGrowth curves for intracranial volume in normal Asian children fortify management of craniosynostosis.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryDetermining the fate of cranial sutures after surgical correction of non-syndromic craniosynostosis.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryDe novo mutations in inhibitors of Wnt, BMP, and Ras/ERK signaling pathways in non-syndromic midline craniosynostosis.
Proceedings of the National Academy of Sciences of the United States of AmericaMultidisciplinary care of craniosynostosis.
Journal of multidisciplinary healthcareBone Fusion in Normal and Pathological Development is Constrained by the Network Architecture of the Human Skull.
Scientific reportsThe metopic-sagittal craniosynostosis-report of 35 operative cases.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryManagement options of non-syndromic sagittal craniosynostosis.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia[Guide to clinical practice for the diagnosis, treatment and rehabilitation of non-syndromic craniosynostosis on 3 levels of care].
Cirugia y cirujanosTwo locus inheritance of non-syndromic midline craniosynostosis via rare SMAD6 and common BMP2 alleles.
eLife[Non syndromic craniosynostosis].
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Low-cost beetle-wing fronto-orbital advancement using nonabsorbable suture fixation for non-syndromic trigonocephaly: A single center experience.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia· 2026· PMID 41724090mais citado
- Fibronectin 1 is required for suture patency and dysregulated across craniosynostosis models in the mouse.
- Daily executive function in children and adolescents with non-syndromic craniosynostosis: association with timing of surgical intervention.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery· 2026· PMID 41820702mais citado
- Feasibility and reproducibility of handheld and table-mounted optical coherence tomography in children with craniosynostosis.
- Incidence of Ocular Abnormalities in Metopic Craniosynostosis: Cranial Vault Reconstruction Versus Endoscopic Suturectomy.The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association· 2026· PMID 41632637mais citado
- Concurrent posterior vault expansion and extradural Chiari decompression in syndromic and non-syndromic craniosynostosis: a case series.
- Partial intracranial volumes in metopic synostosis - pre- and postoperative comparisons with healthy controls.
- Evaluation of long-term aesthetic outcomes of fronto-orbital advancement using a crossing-the-midline greenstick fracture technique in anterior synostotic plagiocephaly.
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Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:620139(Orphanet)
- MONDO:0850075(MONDO)
- GARD:22472(GARD (NIH))
- Busca completa no PubMed(PubMed)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
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