Oryzomys couesi, também conhecido popularmente no inglês como "Coues's rice rat", que seria como "rato-do-arroz-de-Coues" no Português, é um roedor semiaquático da família Cricetidae, encontrado desde o sul do Texas, passando pelo México e América Central, até o noroeste da Colômbia. Geralmente habita ambientes úmidos, como pântanos, mas também vive em florestas mais secas e arbustais.
Introdução
O que você precisa saber de cara
Doença viral transmitida por mosquitos, causando inflamação cerebral em humanos e cavalos. Sintomas incluem febre, dor de cabeça, confusão e convulsões, podendo levar a sequelas neurológicas graves ou morte.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Publicações mais relevantes
Informed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines.
Encephalitogenic alphaviruses are mosquito-borne viruses that can cause fatal disease in humans and equines. Currently, there are no licensed vaccines or antiviral treatments for these infections. Western equine encephalitis virus (WEEV) is a member of this group that had not produced a human infection in over a decade. However, an outbreak of WEEV encephalitis in humans and equines was reported recently in South America, indicating a need for additional countermeasures. Blind passage approaches to generation of RNA virus live attenuated vaccines (LAVs) frequently result in acquisition of positively charged amino acid mutations that confer heparan sulfate (HS) binding and that are attenuating factors in resultant LAVs. To develop an informed approach for creation of alphavirus LAVs, we have utilized the WEEV McMillan (McM) strain as an HS weak/non-binding platform into which we have placed positively charged amino acid substitution mutations at positions in the E2 glycoprotein previously shown to confer HS-dependent infection upon other alphaviruses. This approach yielded four mutants with high efficiency HS binding and avirulence in mice, which were further subjected to yield optimization by in vitro selection of second-site mutations. Interestingly, the original mutations concomitantly increased HS interactions and reduced infection promoted by VLDLR and PCDH10 protein receptors, while the second site mutations improved infectivity mediated by VLDLR. Further, we report a newly generated 4.1Å cryo-EM reconstruction of WEEV McM strain into which we have mapped the mutations to provide an E2 glycoprotein domain-based representation of receptor binding site location.
Investigation of neurotropic arboviruses in wild and domestic animals in Amazon region, 2023-2024.
Arboviruses represent a potential threat to global public health due to their ability to infect various vertebrate hosts and vectors, as well as their adaptability to diverse ecosystems, allowing them to expand geographically across continents. The present study aimed to describe the molecular epidemiology of encephalitic arboviruses, including Venezuelan equine encephalitis virus (VEEV), Eastern equine encephalitis virus (EEEV), Western equine encephalitis virus (WEEV), West Nile virus (WNV), Saint Louis encephalitis virus (SLEV), Toscana virus (TOSV), and Rift Valley fever virus (RVFV) in nervous tissue samples from domestic and wild animals from the Northern region of Brazil, between February 2023 and June 2024. Samples negative for rabies virus were analysed by reverse transcription real-time polymerase chain reaction (RT-qPCR) targeting Alphavirus, Orthoflavivirus and Phlebovirus species.Positive samples were subjected to viral isolation in cell culture and whole-genome sequencing using next-generation sequencing.Phylogenetic and molecular clock analyses were performed to characterise viral lineages and evolutionary relationships. Two samples tested positive for arboviruses by RT-qPCR: one SLEV sample from the state of Amazonas, which showed a low viral load, preventing virus isolation and sequencing, and one Madariaga virus (MADV) sample from the state of Pará, which could be isolated and sequenced.The isolated agent belongs to lineage III of EEEV, showing most similarity to strains from Guyana and Argentina. The present study detected two arboviruses in animals, suggesting its circulation in the study area.
Impact of mutations affecting 4'-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus.
Venezuelan equine encephalitis virus (VEEV) is a prototypical encephalitic alphavirus. Members of the Alphavirus genus are found across the globe, transmitted by arthropod vectors, and cause significant disease burdens in humans and animals. There are currently no FDA-approved antivirals for human use against any member of the Alphavirus genus. While a vaccine exists against chikungunya virus (CHIKV), a member of the arthritogenic alphaviruses, FDA-approved vaccines are not available for other members of this genus, particularly the encephalitic alphaviruses such as VEEV, Eastern equine encephalitis virus, and Western equine encephalitis virus. 4'-Fluorouridine (4'-FlU, EIDD-2749) was recently identified as a broad-spectrum antiviral against multiple RNA viruses, including alphaviruses. 4'-FlU can potently inhibit VEEV-TC83 replication, with submicromolar potency in cell culture. However, the emergence of antiviral resistance represents a hurdle for antiviral drug development and the implementation of effective treatment strategies. Here, we have identified novel mutations in the VEEV nsP4 RNA-dependent RNA polymerase that reduce susceptibility to 4'-FlU, including P187A, Q191L, L289F, and T296I. We rebuilt each mutation in recombinant VEEV-TC83 and characterized the effects of these mutations on fitness and pathogenicity. In addition, we assessed the impact of mutations reducing sensitivity to 4'-FlU in a mouse model. Although mutations against 4'-FlU arise quickly in vitro, treatment can still alleviate severe disease and lethal encephalitis. Together, these data highlight the promising therapeutic potential of 4'-FlU for the treatment of alphavirus encephalitis.IMPORTANCEVenezuelan equine encephalitis virus (VEEV) is a mosquito-spread virus that can cause encephalitis in people and animals. There are no FDA-approved countermeasures to treat VEEV infections in humans. 4'-Fluorouridine (4'-FlU) is currently being developed to treat multiple viral infections, including VEEV. A major problem with antivirals is the appearance of virus populations that are less susceptible to treatment. In this study, we treated infected mice with 4'-FlU and measured how well the compound inhibited virus replication and prevented severe disease. In addition, we identified mutations in VEEV's polymerase that confer reduced susceptibility to 4'-FlU. We then assessed if viruses encoding for these mutations were still pathogenic. Although VEEV can develop mild resistance to 4'-FlU in vitro, administration of 4'-FlU still reduced severe disease and prevented lethality in the animals infected with viruses that possess mutations that decrease susceptibility to 4'-FlU. These results suggest that 4'-FlU has strong potential as a future treatment for alphavirus infections.
Validation of prototype virus inactivation from seven virus families of pandemic potential with a novel low-cost, field-deployable RNA extraction and storage method.
The Centers for Research in Emerging Infectious Diseases (CREID) was established to enhance pandemic preparedness by studying emerging/reemerging pathogens, especially in resource-limited regions. To overcome infrastructure challenges, a low-cost, field-deployable method for extracting total nucleic acids is essential, eliminating reliance on expensive equipment, power, and cold chain systems used in traditional extraction techniques. To address this challenge, we developed an RNA extraction and storage method (RNAES) that meets these criteria. Herein, we report RNAES inactivation efficacy against nine prototype viruses (Middle Eastern respiratory syndrome coronavirus, Japanese encephalitis virus, West Nile virus, Hantaan virus, measles virus, Heartland virus, enterovirus A71, chikungunya virus, and Western equine encephalitis virus) representing seven pandemic potential virus families. We compare the RNAES method to the Qiagen QIAamp kit across various viral loads and field sample types. The presence of infectious virus in RNA samples was quantified using plaque assays. Successful inactivation of viruses was demonstrated for six enveloped virus families spiked into matrices routinely collected at field sites. The seventh family tested (Picornaviridae) was not completely inactivated, likely due to non-enveloped viruses being differentially susceptible to the lysis chemistry of the RNAES kit. The commercial comparator inactivated all viruses tested. Specialized biosafety facilities, specific detailed permits, and comprehensive logistics are required to ensure safety when handling and shipping potentially infectious samples. Inactivating pathogens at the point of collection reduces risks and simplifies sample transfer for critical outbreak research. Confidently ensuring that an isolated nucleic acid sample is non-infectious using RNAES will enable safer, and more efficient downstream analysis.
Structural insights into VLDLR recognition by western equine encephalitis virus.
Western equine encephalitis virus (WEEV), a group of encephalitic alphaviruses that cause severe diseases in humans and equids, historically used the very-low-density lipoprotein receptor (VLDLR) as a receptor during infection. However, current epidemic strains no longer use VLDLR as a receptor. In this study, we identify that LA1, LA2, LA3, and LA5 of VLDLR can directly interact with WEEV. Using cryo-electron microscopy, we investigate the structures of complexes formed between WEEV and VLDLR-LBD or other VLDLR fragments. Our findings show that LA1 and LA2 insert into a cleft formed by two adjacent E2-E1 heterodimers within a single trimeric spike, while LA3 and LA5 interact with the DIII region of WEEV E1. Among VLDLR concatemers, the LA1-5 exhibits the strongest binding affinity for WEEV. Additionally, we find that a single polymorphism in the E2 glycoprotein determines WEEV's receptor tropism. Mutations E2E181K or E2E81K in the nonpathogenic strain Imperial-181 enhanced its ability to enter via VLDLR. These results enhance our understanding of alphavirus receptor recognition and receptor usage shifts, providing insights for the development of antiviral therapies.
Publicações recentes
Investigation of neurotropic arboviruses in wild and domestic animals in Amazon region, 2023-2024.
Informed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines.
Impact of mutations affecting 4'-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus.
Structural insights into VLDLR recognition by western equine encephalitis virus.
Western equine encephalitis virus: A comprehensive review of epidemics, transmission, hosts, and strategies for mitigation.
📚 EuropePMC257 artigos no totalmostrando 127
Investigation of neurotropic arboviruses in wild and domestic animals in Amazon region, 2023-2024.
Memorias do Instituto Oswaldo CruzInformed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines.
PLoS pathogensImpact of mutations affecting 4'-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus.
Journal of virologyStructural insights into VLDLR recognition by western equine encephalitis virus.
Nature communicationsWestern equine encephalitis virus: A comprehensive review of epidemics, transmission, hosts, and strategies for mitigation.
VirulenceValidation of prototype virus inactivation from seven virus families of pandemic potential with a novel low-cost, field-deployable RNA extraction and storage method.
Journal of virological methodsSyndromic approach for rapid detection and differentiation of human pathogenic alphaviruses.
Journal of clinical virology : the official publication of the Pan American Society for Clinical VirologyDevelopment Rate of the Larvae of the Mosquito Aedes albifasciatus: A Mathematical Model as Decision Tool.
Neotropical entomologyMeteorological Effects on the Abundance of West Nile Virus Mosquito Vectors in Two Communities Located on the Texas-Mexico Border in the Northern Chihuahuan Desert.
Vector borne and zoonotic diseases (Larchmont, N.Y.)An alphavirus vaccine development utilizing RNA replication-defective strategy.
Molecular therapy : the journal of the American Society of Gene TherapyDevelopment of in vitro and in vivo neutralization assays for New World alphaviruses based on the VSV pseudovirus system.
Emerging microbes & infectionsChimeric Vesicular Stomatitis Virus Bearing Western Equine Encephalitis Virus Envelope Proteins E2-E1 Is a Suitable Surrogate for Western Equine Encephalitis Virus in a Plaque Reduction Neutralization Test.
VirusesUltra-fast, palm-sized platform for visual point-of-care virus detection using convective PCR with gold nanoparticle probes.
Mikrochimica actaStructural basis for engagement of Western Equine Encephalitis Virus with the PCDH10 receptor.
Nature communicationsBroad spectrum antiviral BDGR-164 provides protection against lethal neurotropic alphavirus infection in mice.
Antiviral researchMachine learning identifies genes linked to neurological disorders induced by equine encephalitis viruses, traumatic brain injuries, and organophosphorus nerve agents.
Frontiers in computational neuroscienceStructural basis for the recognition of two different types of receptors by Western equine encephalitis virus.
Cell reportsDecoding WEEV's host adaptation.
Cell host & microbeThe impact of temperature and insect-specific viruses on the transmission of alphaviruses by Aedes japonicus japonicus.
Microbiology spectrumAtypical complication of western equine encephalitis: central hypoventilation syndrome.
Colombia medica (Cali, Colombia)Diagnosis and genomic characterization of the largest western equine encephalitis virus outbreak in Uruguay during 2023-2024.
Npj virusesMolecular basis for shifted receptor recognition by an encephalitic arbovirus.
CellStructural basis for plasticity in receptor engagement by an encephalitic alphavirus.
CellLow capacity for molecular detection of Alphaviruses other than Chikungunya virus in 23 European laboratories, March 2022.
PloS oneNeuropathogenesis of Encephalitic Alphaviruses in Non-Human Primate and Mouse Models of Infection.
Pathogens (Basel, Switzerland)Host-feeding behavior of mosquitoes (Diptera: Culicidae) in North Dakota, 2003 to 2006.
Journal of medical entomologyThe antiviral BDGR-49 provides protection from lethal, neurotropic Venezuelan equine encephalitis virus intranasal infection in mice.
Journal of virologyAdvances in antiviral strategies targeting mosquito-borne viruses: cellular, viral, and immune-related approaches.
Virology journalnsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice.
ACS infectious diseasesNeurological manifestations of encephalitic alphaviruses, traumatic brain injuries, and organophosphorus nerve agent exposure.
Frontiers in neuroscienceEffects of climate change on the occurrence and distribution of Western equine encephalitis virus in South America.
Public health[Western equine encephalitis: Brainstem involvement and clinical manifestations].
MedicinaEquine Encephalomyelitis Outbreak, Uruguay, 2023-2024.
Emerging infectious diseasesOutbreak of Western Equine Encephalitis Virus Infection Associated with Neurological Disease in Horses Following a Nearly 40-Year Intermission Period in Argentina.
VirusesUnveiling the Threat: Battling the Resurgence of Western Equine Encephalitis (WEE).
Infectious disorders drug targetsThe VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses.
Cell reportsPCDH10 is a neuronal receptor for western equine encephalitis virus.
Cell researchWestern equine encephalitis: a pediatric case report.
Archivos argentinos de pediatriaMolecular Epidemiology of Western Equine Encephalitis Virus, South America, 2023-2024.
Emerging infectious diseasesWestern equine encephalitis, a report of two cases in pediatric patients.
Archivos argentinos de pediatriaShifts in receptors during submergence of an encephalitic arbovirus.
NatureAn improved alphaviruses-specific RT-qPCR facilitates monitoring and prevention of alphaviruses.
Journal of medical virologySyrian Hamsters Model Does Not Reflect Human-like Disease after Aerosol Exposure to Encephalitic Alphaviruses.
Methods and protocolsMolecular epidemiology of Western equine encephalitis virus in Brazil, 2023-2024.
medRxiv : the preprint server for health sciencesSafety and immunogenicity of a novel trivalent recombinant MVA-based equine encephalitis virus vaccine: A Phase 1 clinical trial.
Vaccine[Preparation of mouse monoclonal antibodies against the ectodomain of Western equine encephalitis virus E2 (E2ecto) protein].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunologyThe low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses.
Nature communicationsVertebrate-class-specific binding modes of the alphavirus receptor MXRA8.
CellN4 -Hydroxycytidine/Molnupiravir Inhibits RNA-Virus Induced Encephalitis by Producing Mutated Viruses with Reduced Fitness.
bioRxiv : the preprint server for biologyIsolation of Flaviviruses and Alphaviruses with Encephalitogenic Potential Diagnosed by Evandro Chagas Institute (Pará, Brazil) in the Period of 1954-2022: Six Decades of Discoveries.
VirusesSequelae and Animal Modeling of Encephalitic Alphavirus Infections.
VirusesIn Vitro and In Vivo Phenotypes of Venezuelan, Eastern and Western Equine Encephalitis Viruses Derived from cDNA Clones of Human Isolates.
VirusesFirst comprehensive report of the resistance of Culex quinquefasciatus Say (Diptera: Culicidae) to commonly used insecticides in Riyadh, Saudi Arabia.
HeliyonActivity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus.
Journal of virologyUnderstanding host responses to equine encephalitis virus infection: implications for therapeutic development.
Expert review of anti-infective therapyEfficacy of Western, Eastern, and Venezuelan Equine Encephalitis (WEVEE) Virus-Replicon Particle (VRP) Vaccine against WEEV in a Non-Human Primate Animal Model.
VirusesIdentification of salivary gland escape barriers to western equine encephalitis virus in the natural vector, Culex tarsalis.
PloS oneInactivation of Venezuelan Equine Encephalitis Virus Genome Using Two Methods.
VirusesCross-Strain Neutralizing and Protective Monoclonal Antibodies against EEEV or WEEV.
VirusesExternal quality assessment of molecular testing of 9 viral encephalitis-related viruses in China.
Virus researchExposing cryptic epitopes on the Venezuelan equine encephalitis virus E1 glycoprotein prior to treatment with alphavirus cross-reactive monoclonal antibody allows blockage of replication early in infection.
VirologyAstrocyte inflammatory signaling mediates α-synuclein aggregation and dopaminergic neuronal loss following viral encephalitis.
Experimental neurologyPan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope.
CellSeroprevalence of arboviruses in Ecuador: Implications for improved surveillance.
Biomedica : revista del Instituto Nacional de SaludWestern equine encephalitis virus virus-like particles from an insect cell-baculovirus system elicit the strong immune responses in mice.
Biotechnology journalSynthesis and biological activity of conformationally restricted indole-based inhibitors of neurotropic alphavirus replication: Generation of a three-dimensional pharmacophore.
Bioorganic & medicinal chemistry lettersSerological evidence of Eastern equine encephalitis circulation in equids in Pará state, Brazil.
Brazilian journal of veterinary medicineA Tale of 20 Alphaviruses; Inter-species Diversity and Conserved Interactions Between Viral Non-structural Protein 3 and Stress Granule Proteins.
Frontiers in cell and developmental biologyBeat the heat: Culex quinquefasciatus regulates its body temperature during blood feeding.
Journal of thermal biologyStabilization of a Broadly Neutralizing Anti-Chikungunya Virus Single Domain Antibody.
Frontiers in medicineA Monovalent and Trivalent MVA-Based Vaccine Completely Protects Mice Against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenge.
Frontiers in immunologyFirst Record of Mosquito-Borne Kyzylagach Virus in Central Europe.
VirusesThe Western Equine Encephalitis Lyophilized, Inactivated Vaccine: An Update on Safety and Immunogenicity.
Frontiers in immunologyTransmission of West Nile and five other temperate mosquito-borne viruses peaks at temperatures between 23°C and 26°C.
eLifeComparative pathology study of Venezuelan, eastern, and western equine encephalitis viruses in non-human primates.
Antiviral researchImmunopathogenesis of alphaviruses.
Advances in virus researchImpact of alphavirus 3'UTR plasticity on mosquito transmission.
Seminars in cell & developmental biologySerosurvey of Eastern, Western, and Venezuelan Equine Encephalitis Viruses in Wild Boars (Sus scrofa), Hunting Dogs, and Hunters of Brazil.
Vector borne and zoonotic diseases (Larchmont, N.Y.)Vaccine Advances against Venezuelan, Eastern, and Western Equine Encephalitis Viruses.
VaccinesHow virus size and attachment parameters affect the temperature sensitivity of virus binding to host cells: Predictions of a thermodynamic model for arboviruses and HIV.
Microbial risk analysisTowards a thermodynamic mechanistic model for the effect of temperature on arthropod vector competence for transmission of arboviruses.
Microbial risk analysisEncephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry.
mBio"Submergence" of Western equine encephalitis virus: Evidence of positive selection argues against genetic drift and fitness reductions.
PLoS pathogensComplete Coding Sequence of Western Equine Encephalitis Virus Strain Fleming, Isolated from a Human Case.
Microbiology resource announcementsThe Capsid Protein of Semliki Forest Virus Antagonizes RNA Interference in Mammalian Cells.
Journal of virologyAgua Salud alphavirus defines a novel lineage of insect-specific alphaviruses discovered in the New World.
The Journal of general virologyCooperativity between the 3' untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus.
PLoS pathogensSelection of Single-Domain Antibodies towards Western Equine Encephalitis Virus.
Antibodies (Basel, Switzerland)Infection with mosquito-borne alphavirus induces selective loss of dopaminergic neurons, neuroinflammation and widespread protein aggregation.
NPJ Parkinson's diseaseThe prophylactic and therapeutic activity of a broadly active ribonucleoside analog in a murine model of intranasal venezuelan equine encephalitis virus infection.
Antiviral researchSEROLOGICAL SURVEY FOR SELECT INFECTIOUS AGENTS IN WILD MAGELLANIC PENGUINS (SPHENISCUS MAGELLANICUS) IN ARGENTINA, 1994-2008.
Journal of wildlife diseasesNew World alphavirus protein interactomes from a therapeutic perspective.
Antiviral researchBroad-spectrum monoclonal antibodies against chikungunya virus structural proteins: Promising candidates for antibody-based rapid diagnostic test development.
PloS oneContinued Evidence of Decline in the Enzootic Activity of Western Equine Encephalitis Virus in Colorado.
Journal of medical entomologyZoonotic Viral Diseases of Equines and Their Impact on Human and Animal Health.
The open virology journalGenetic control of alphavirus pathogenesis.
Mammalian genome : official journal of the International Mammalian Genome SocietyRepurposed FDA-Approved drug sorafenib reduces replication of Venezuelan equine encephalitis virus and other alphaviruses.
Antiviral researchWing morphometrics of Aedes (Ochlerotatus) albifasciatus (Macquart, 1838) (Diptera: Culicidae) from different climatic regions of Argentina.
Parasites & vectorsGenomic Characterization and Seroprevalence Studies on Alphaviruses in Uruguay.
The American journal of tropical medicine and hygieneHuman-Like Neutralizing Antibodies Protect Mice from Aerosol Exposure with Western Equine Encephalitis Virus.
VirusesSerological evidence of widespread exposure of Grenada fruit bats to chikungunya virus.
Zoonoses and public healthHost-Feeding Patterns of Culex stigmatosoma (Diptera: Culicidae) in Southern California.
Journal of medical entomologyVenezuelan Equine Encephalitis Virus Capsid-The Clever Caper.
VirusesSusceptibility and Lethality of Western Equine Encephalitis Virus in Balb/c Mice When Infected by the Aerosol Route.
VirusesThe role of birds in arboviral disease surveillance in Harris County and the City of Houston, Texas.
U.S. Army Medical Department journalPotential Sympatric Vectors and Mammalian Hosts of Venezuelan Equine Encephalitis Virus in Southern Mexico.
Journal of wildlife diseasesDiscovery of a novel alphavirus related to Eilat virus.
The Journal of general virologyExploring genetic variation in haplotypes of the filariasis vector Culex quinquefasciatus (Diptera: Culicidae) through DNA barcoding.
Acta tropicaA Quantitative Real-Time RT-PCR Assay for the Detection of Venezuelan equine encephalitis virus Utilizing a Universal Alphavirus Control RNA.
BioMed research internationalSelective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells.
PLoS neglected tropical diseasesNotice to Readers: Final 2015 Reports of Nationally Notifiable Infectious Diseases and Conditions.
MMWR. Morbidity and mortality weekly reportAblation of Programmed -1 Ribosomal Frameshifting in Venezuelan Equine Encephalitis Virus Results in Attenuated Neuropathogenicity.
Journal of virologyVenezuelan and western equine encephalitis virus E1 liposome antigen nucleic acid complexes protect mice from lethal challenge with multiple alphaviruses.
VirologyAlphavirus protease inhibitors from natural sources: A homology modeling and molecular docking investigation.
Computational biology and chemistryHospitalized Children With Encephalitis in the United States: A Pediatric Health Information System Database Study.
Pediatric neurologyAvian Encephalomyelitis in Layer Pullets Associated with Vaccination.
Avian diseasesCulex Tarsalis Mosquitoes as Vectors of Highlands J Virus.
Vector borne and zoonotic diseases (Larchmont, N.Y.)Virus-specific thermostability and heat inactivation profiles of alphaviruses.
Journal of virological methodsEntry Sites of Venezuelan and Western Equine Encephalitis Viruses in the Mouse Central Nervous System following Peripheral Infection.
Journal of virologyMolecular determinants of alphavirus neuropathogenesis in mice.
The Journal of general virologySurveillance for Western Equine Encephalitis, St. Louis Encephalitis, and West Nile Viruses Using Reverse Transcription Loop-Mediated Isothermal Amplification.
PloS oneOccurrence of antibodies anti -Toxoplasma gondii, Neospora caninum and Leptospira interrogans in a captive deer herd in Southern Brazil.
Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia VeterinariaMultiplex qRT-PCR for the Detection of Western Equine Encephalomyelitis, St. Louis Encephalitis, and West Nile Viral RNA in Mosquito Pools (Diptera: Culicidae).
Journal of medical entomology[Establishment of a One-Step Real-Time RT-PCR Method for the Detection of Venezuelan Equine Encephalitis Virus].
Bing du xue bao = Chinese journal of virologyHuman and animal health on three continents--a biography of the early life of Karl Friedrich Meyer (1884-1974).
Pathogens and diseaseThe ubiquitin proteasome system plays a role in venezuelan equine encephalitis virus infection.
PloS oneThe combined use of alphavirus replicons and pseudoinfectious particles for the discovery of antivirals derived from natural products.
Journal of biomolecular screeningAssociações
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Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Informed mutation of western equine encephalitis virus to heparan sulfate binding: Implications for rational design of alphavirus live attenuated vaccines.
- Investigation of neurotropic arboviruses in wild and domestic animals in Amazon region, 2023-2024.
- Impact of mutations affecting 4'-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus.
- Validation of prototype virus inactivation from seven virus families of pandemic potential with a novel low-cost, field-deployable RNA extraction and storage method.
- Structural insights into VLDLR recognition by western equine encephalitis virus.
- Western equine encephalitis virus: A comprehensive review of epidemics, transmission, hosts, and strategies for mitigation.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:83593(Orphanet)
- MONDO:0019380(MONDO)
- GARD:7888(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q18553953(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
