Raras
Buscar doenças, sintomas, genes...
Encefalite equina oriental
ORPHA:83594CID-10 · A83.2CID-11 · 1C84DOENÇA RARA

O mosquito-tigre-asiático pertence ao grupo Scutellaris do subgênero Stegomyia. É considerada a segunda espécie de culicídeos (Culicidae) em importância para o homem, como vetor do vírus da dengue, sendo superado apenas pelo Aedes aegypti (Lineu) A dengue coloca em risco a saúde de 2.5 a 3 bilhões de pessoas que habitam as regiões urbanas e suburbanas de 100 países das regiões tropicais e subtropicais de todo o mundo. Conta em quarto lugar na lista 100 das espécies exóticas invasoras mais daninhas do mundo e na Lista de espécies invasoras no Brasil.

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Introdução

O que você precisa saber de cara

📋

Doença viral rara transmitida por mosquitos, causa inflamação grave no cérebro, com sintomas neurológicos agudos e alta mortalidade. Afeta principalmente cavalos, mas pode infectar humanos.

Publicações científicas
706 artigos
Último publicado: 2026 Apr 6

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: A83.2
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico706PubMed
Últimos 10 anos200publicações
Pico202142 papers
Linha do tempo
2026Hoje · 2026🧪 2008Primeiro ensaio clínico📈 2021Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

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Nenhum gene associado encontrado

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Diagnóstico

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
2Fase 22
1Fase 11
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 3 ensaios
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Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Encefalite equina oriental

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

3 ensaios clínicos encontrados.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
311 papers (10 anos)
#1

Observations of the developmental stages of Coquillettidia perturbans (Diptera: Culicidae) with special reference to the pupal trumpets.

Journal of insect science (Online)2026 Mar 02

Coquillettidia perturbans (Walker) is a North American mosquito species of medical and veterinary importance that has been implicated as a vector of eastern equine encephalitis virus. Larval and pupal C. perturbans possess highly specialized respiratory appendages that enable them to respire from air vesicles in the hollow roots and shoots of emergent aquatic vegetation, which means that the larval and pupal stages have remained largely understudied. Field-collected C. perturbans larvae, pupae, and adults were studied under laboratory conditions in an attempt to establish a laboratory colony. Blood-fed adults successfully laid egg rafts in containers provisioned with water hyacinth plants (Pontederia crassipes). Larvae and pupae were maintained on hydroponically grown wheat seedlings (Triticum sp.). Images and descriptions of egg rafts, larvae, and pupae are provided with special reference to hatch success, larval instar traits and pupal trumpet morphology.

#2

Isolation of Madariaga Virus (MADV) in a Horse Coinfected with Equine Infectious Anemia in Venezuela: A Review of MADV Circulation in the Country.

Veterinary sciences2026 Jan 10

Madariaga virus (MADV), formerly known as the South American variant of Eastern Equine Encephalitis virus (EEEV), is an alphavirus that belongs to the Togaviridae family and has been periodically infecting equids in Venezuela since its first identification in 1975. This study reports the isolation and molecular characterization of MADV isolated from a horse in December 2024 in the context of MADV cases reported in Venezuela. Antibodies to the rabies virus were detected by indirect immunofluorescence, and to the Equine Infectious Anemia virus (EIAV) by passive immunodiffusion. MADV RNA was detected by qRT-PCR. The sequence of the complete viral genome was obtained by next-generation sequencing. The sequence of this virus was highly similar to that of the only human case of MADV reported in the country in 2016, as well as to a sequence of a virus isolated from a horse in Colombia in 2002. The horse was found to be co-infected with EIAV. The continuous circulation of MADV in Venezuela warrants reinforcing the preventive measures against these alphaviruses, which ignore borders, and may cause important animal and human health concerns.

#3

Investigation of neurotropic arboviruses in wild and domestic animals in Amazon region, 2023-2024.

Memorias do Instituto Oswaldo Cruz2026

Arboviruses represent a potential threat to global public health due to their ability to infect various vertebrate hosts and vectors, as well as their adaptability to diverse ecosystems, allowing them to expand geographically across continents. The present study aimed to describe the molecular epidemiology of encephalitic arboviruses, including Venezuelan equine encephalitis virus (VEEV), Eastern equine encephalitis virus (EEEV), Western equine encephalitis virus (WEEV), West Nile virus (WNV), Saint Louis encephalitis virus (SLEV), Toscana virus (TOSV), and Rift Valley fever virus (RVFV) in nervous tissue samples from domestic and wild animals from the Northern region of Brazil, between February 2023 and June 2024. Samples negative for rabies virus were analysed by reverse transcription real-time polymerase chain reaction (RT-qPCR) targeting Alphavirus, Orthoflavivirus and Phlebovirus species.Positive samples were subjected to viral isolation in cell culture and whole-genome sequencing using next-generation sequencing.Phylogenetic and molecular clock analyses were performed to characterise viral lineages and evolutionary relationships. Two samples tested positive for arboviruses by RT-qPCR: one SLEV sample from the state of Amazonas, which showed a low viral load, preventing virus isolation and sequencing, and one Madariaga virus (MADV) sample from the state of Pará, which could be isolated and sequenced.The isolated agent belongs to lineage III of EEEV, showing most similarity to strains from Guyana and Argentina. The present study detected two arboviruses in animals, suggesting its circulation in the study area.

#4

Impact of mutations affecting 4'-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus.

Journal of virology2026 Feb 17

Venezuelan equine encephalitis virus (VEEV) is a prototypical encephalitic alphavirus. Members of the Alphavirus genus are found across the globe, transmitted by arthropod vectors, and cause significant disease burdens in humans and animals. There are currently no FDA-approved antivirals for human use against any member of the Alphavirus genus. While a vaccine exists against chikungunya virus (CHIKV), a member of the arthritogenic alphaviruses, FDA-approved vaccines are not available for other members of this genus, particularly the encephalitic alphaviruses such as VEEV, Eastern equine encephalitis virus, and Western equine encephalitis virus. 4'-Fluorouridine (4'-FlU, EIDD-2749) was recently identified as a broad-spectrum antiviral against multiple RNA viruses, including alphaviruses. 4'-FlU can potently inhibit VEEV-TC83 replication, with submicromolar potency in cell culture. However, the emergence of antiviral resistance represents a hurdle for antiviral drug development and the implementation of effective treatment strategies. Here, we have identified novel mutations in the VEEV nsP4 RNA-dependent RNA polymerase that reduce susceptibility to 4'-FlU, including P187A, Q191L, L289F, and T296I. We rebuilt each mutation in recombinant VEEV-TC83 and characterized the effects of these mutations on fitness and pathogenicity. In addition, we assessed the impact of mutations reducing sensitivity to 4'-FlU in a mouse model. Although mutations against 4'-FlU arise quickly in vitro, treatment can still alleviate severe disease and lethal encephalitis. Together, these data highlight the promising therapeutic potential of 4'-FlU for the treatment of alphavirus encephalitis.IMPORTANCEVenezuelan equine encephalitis virus (VEEV) is a mosquito-spread virus that can cause encephalitis in people and animals. There are no FDA-approved countermeasures to treat VEEV infections in humans. 4'-Fluorouridine (4'-FlU) is currently being developed to treat multiple viral infections, including VEEV. A major problem with antivirals is the appearance of virus populations that are less susceptible to treatment. In this study, we treated infected mice with 4'-FlU and measured how well the compound inhibited virus replication and prevented severe disease. In addition, we identified mutations in VEEV's polymerase that confer reduced susceptibility to 4'-FlU. We then assessed if viruses encoding for these mutations were still pathogenic. Although VEEV can develop mild resistance to 4'-FlU in vitro, administration of 4'-FlU still reduced severe disease and prevented lethality in the animals infected with viruses that possess mutations that decrease susceptibility to 4'-FlU. These results suggest that 4'-FlU has strong potential as a future treatment for alphavirus infections.

#5

MOSQUITO SPECIES OF NEW YORK STATE: AN UPDATED CHECKLIST WITH PUBLIC AND VETERINARY HEALTH SIGNIFICANCE.

Journal of the American Mosquito Control Association2026 Jan 08

We present an updated checklist of mosquito species in New York State, integrating historical records, modern surveillance, and recent literature. A total of 68 species across 10 genera are documented, including invasive taxa (Aedes albopictus, Ae. japonicus) and historically rare species (Orthopodomyia alba, Or. signifera). This synthesis emphasizes species of public and veterinary significance, such as Culex pipiens and Culiseta melanura, vectors of West Nile and eastern equine encephalitis viruses. Analysis of more than 3 million specimens collected since 1999 confirms the absence of Ae. aegypti, historically introduced but unable to persist in New York. Urbanization, container-breeding ecology, climate change, and global commerce continue to shape mosquito distributions and pathogen risk. This checklist bridges historic and current data, providing a reliable reference for surveillance, vector control, and future research.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC392 artigos no totalmostrando 196

2026

Investigation of neurotropic arboviruses in wild and domestic animals in Amazon region, 2023-2024.

Memorias do Instituto Oswaldo Cruz
2026

Observations of the developmental stages of Coquillettidia perturbans (Diptera: Culicidae) with special reference to the pupal trumpets.

Journal of insect science (Online)
2026

Isolation of Madariaga Virus (MADV) in a Horse Coinfected with Equine Infectious Anemia in Venezuela: A Review of MADV Circulation in the Country.

Veterinary sciences
2026

Impact of mutations affecting 4'-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus.

Journal of virology
2025

In Silico Characterization of Conserved Epitopes in Alphavirus E2 Proteins: A Promising Approach for Pan-vaccine Design.

ACS omega
2025

Trans-complementation of chikungunya virus replicase mutants reveals alphavirus replication complexity and supports antiviral tool development.

PLoS pathogens
2025

Zoonotic Disease Transmission May Be Linked to Host Co-Occurrence Network Topology.

Annals of the New York Academy of Sciences
2026

MOSQUITO SPECIES OF NEW YORK STATE: AN UPDATED CHECKLIST WITH PUBLIC AND VETERINARY HEALTH SIGNIFICANCE.

Journal of the American Mosquito Control Association
2026

Eastern equine encephalitis virus and identification of host bloodmeal sources from individual Culiseta melanura (Diptera: Culicidae) at an enzootic focus in central New York State.

Journal of medical entomology
2025

Ion-Channel-Targeting Drugs for Chikungunya Virus.

Molecules (Basel, Switzerland)
2026

A retrospective study of 171 cases of equine meningoencephalomyelitis in the United States, 1996-2023.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
2025

An alphavirus vaccine development utilizing RNA replication-defective strategy.

Molecular therapy : the journal of the American Society of Gene Therapy
2025

Development of in vitro and in vivo neutralization assays for New World alphaviruses based on the VSV pseudovirus system.

Emerging microbes &amp; infections
2025

Structural elucidation of a unique binding mode by an intact alphavirus human IgG molecule to a quaternary epitope.

Nature communications
2025

Eastern Equine Encephalitis Virus Exhibits More Charged Amino Acids in Its Envelope Proteins, Compared to Madariaga Virus.

The American journal of tropical medicine and hygiene
2025

Three positively charged binding sites on the eastern equine encephalitis virus E2 glycoprotein coordinate heparan sulfate- and protein receptor-dependent infection.

Nature communications
2025

Highly sensitive and multiplex detection of nine potential bioterrorism viral agents in a single reaction by multiplex probe amplification (MPA) with melting curve analysis.

Microbiology spectrum
2025

What Is Eastern Equine Encephalitis?

JAMA
2025

Eastern Equine Encephalitis in the US.

JAMA
2025

A detailed kinetic model of Eastern equine encephalitis virus replication in a susceptible host cell.

PLoS computational biology
2025

Broad spectrum antiviral BDGR-164 provides protection against lethal neurotropic alphavirus infection in mice.

Antiviral research
2025

Successful Inactivation of High-Consequence Pathogens in PrimeStore Molecular Transport Media.

Viruses
2025

Basic patches on the E2 glycoprotein of eastern equine encephalitis virus influence viral vascular clearance and dissemination in mice.

Journal of virology
2025

Prevalence and Pathology Associated with Sarcocystis spp. in Raptors in Tennessee, USA.

Journal of wildlife diseases
2025

Powassan and Eastern Equine Encephalitis Virus Seroprevalence in Endemic Areas, United States, 2019-2020.

Emerging infectious diseases
2025

Insect-specific virus platforms for arbovirus vaccine development.

Frontiers in immunology
2025

Exposure to non-endemic arboviruses (alphaviruses) in Costa Rica assessed from human samples collected in areas with contrasting levels of dengue endemicity.

Frontiers in public health
2025

Optimization of a panel of behavioral tests for use in containment using a golden Syrian hamster model.

Journal of virological methods
2025

Eastern equine encephalitis virus: Pathogenesis, immune response, and clinical manifestations.

Infectious medicine
2025

Low capacity for molecular detection of Alphaviruses other than Chikungunya virus in 23 European laboratories, March 2022.

PloS one
2025

Neuropathogenesis of Encephalitic Alphaviruses in Non-Human Primate and Mouse Models of Infection.

Pathogens (Basel, Switzerland)
2024

The clinical and radiographic features of eastern equine encephalitis: A single-center retrospective case series.

Medicine
2025

The antiviral BDGR-49 provides protection from lethal, neurotropic Venezuelan equine encephalitis virus intranasal infection in mice.

Journal of virology
2025

Arthropod-Borne and Rodent-Borne Infections in Peru From 1990 to 2022.

The Journal of infectious diseases
2025

Detection of Zoonotic Arboviruses in Ruffed Grouse (Bonasa umbellus) in the Upper Midwest, USA, 2018-2022.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2025

Serologic and Molecular Evidence of Arboviruses in Nonhuman Primates in Northeast Brazil.

EcoHealth
2024

Eastern Equine Encephalitis Virus: The Importance of Metabolism and Aging.

International journal of molecular sciences
2024

Mosquito аbundance and species surveillance in St. Joseph County, Indiana, 1976-1997.

Biodiversity data journal
2025

nsP2 Protease Inhibitor Blocks the Replication of New World Alphaviruses and Offer Protection in Mice.

ACS infectious diseases
2024

Neurological manifestations of encephalitic alphaviruses, traumatic brain injuries, and organophosphorus nerve agent exposure.

Frontiers in neuroscience
2024

Formalin and 2.5% Glutaraldehyde/2% Paraformaldehyde in 0.1 M Cacodylate Buffer Inactivation Protocols to Ensure the Proper Fixation of Positive Sense RNA Viruses and Genomic Material Prior to Removal from Containment.

Methods and protocols
2025

The sticky business of Alphavirus capsid-host interactions.

Trends in microbiology
2024

Eastern equine encephalitis: a critical dermatological clue in Massachusetts' health crisis.

Archives of dermatological research
2024

Re-emergence of Eastern equine encephalitis: A looming threat in the era of climate change.

New microbes and new infections
2024

The VLDLR entry receptor is required for the pathogenesis of multiple encephalitic alphaviruses.

Cell reports
2024

Public health contributions of entomological surveillance of West Nile virus (WNV) and other mosquito-borne arboviruses in a context of climate change.

Canada communicable disease report = Releve des maladies transmissibles au Canada
2024

Identifying novel chemical matter against the Chikungunya virus nsP3 macrodomain through crystallographic fragment screening.

bioRxiv : the preprint server for biology
2024

FIRST RECORDS OF AEDES TORMENTOR AND CULEX PANOCOSSA AS A RESULT OF VECTOR SURVEILLANCE ACTIVITIES CONDUCTED DURING THE CHARACTERIZATION OF FOCI OF EASTERN EQUINE ENCEPHALITIS IN TAMAULIPAS, MEXICO.

Journal of the American Mosquito Control Association
2024

The receptor VLDLR binds Eastern Equine Encephalitis virus through multiple distinct modes.

Nature communications
2024

Structural basis for VLDLR recognition by eastern equine encephalitis virus.

Nature communications
2024

An improved alphaviruses-specific RT-qPCR facilitates monitoring and prevention of alphaviruses.

Journal of medical virology
2024

Syrian Hamsters Model Does Not Reflect Human-like Disease after Aerosol Exposure to Encephalitic Alphaviruses.

Methods and protocols
2024

Uncertainties Surrounding Madariaga Virus, a Member of the Eastern Equine Encephalitis Virus Complex.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2024

Enhancing Eastern Equine Encephalitis Virus Surveillance in New Jersey: Optimized Collection of Culiseta melanura.

Journal of the American Mosquito Control Association
2024

Bovine astrovirus and its role in lymphocytic encephalitis in cattle in Ontario, Canada, 1988-2019.

Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc
2024

Safety and immunogenicity of a novel trivalent recombinant MVA-based equine encephalitis virus vaccine: A Phase 1 clinical trial.

Vaccine
2024

MVA-based vaccines are protective against lethal eastern equine encephalitis virus aerosol challenge in cynomolgus macaques.

NPJ vaccines
2024

Comprehensive Assessment of Inactivation Methods for Madariaga Virus.

Viruses
2024

Host associations of Culex panocossa (Diptera: Culicidae) in southern Florida and its implications for arbovirus transmission.

Journal of medical entomology
2024

Virology, ecology, epidemiology, pathology, and treatment of eastern equine encephalitis.

Journal of the neurological sciences
2023

Brilacidin as a Broad-Spectrum Inhibitor of Enveloped, Acutely Infectious Viruses.

Microorganisms
2024

Designing a Multiepitope Vaccine against Eastern Equine Encephalitis Virus: Immunoinformatics and Computational Approaches.

ACS omega
2024

Culex erraticus (Diptera: Culicidae) utilizes gopher tortoise burrows for overwintering in North Central Florida.

Journal of medical entomology
2024

Structural and functional basis of VLDLR usage by Eastern equine encephalitis virus.

Cell
2024

The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses.

Nature communications
2023

Structural and functional basis of VLDLR receptor usage by Eastern equine encephalitis virus.

bioRxiv : the preprint server for biology
2023

Real-time RT-PCR for Venezuelan equine encephalitis complex, Madariaga, and Eastern equine encephalitis viruses: application in human and mosquito public health surveillance in Panama.

Journal of clinical microbiology
2024

Trends in emerging vector-borne viral infections and their outcome in children over two decades.

Pediatric research
2023

Alphavirus-based replicons demonstrate different interactions with host cells and can be optimized to increase protein expression.

Journal of virology
2024

Eastern Equine Encephalitis Virus: A Case Report and Brief Literature Review of Current Therapeutic and Preventative Strategies.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2023

West Nile Virus and Other Nationally Notifiable Arboviral Diseases - United States, 2021.

MMWR. Morbidity and mortality weekly report
2023

Eastern Equine Encephalitis Virus Diversity in Massachusetts Patients, 1938-2020.

The American journal of tropical medicine and hygiene
2023

Dynamics of eastern equine encephalitis virus during the 2019 outbreak in the Northeast United States.

Current biology : CB
2023

Mapping the abundance of endemic mosquito-borne diseases vectors in southern Quebec.

BMC public health
2023

Clinical Characteristics of the 2019 Eastern Equine Encephalitis Outbreak in Michigan.

Open forum infectious diseases
2023

Double-stranded RNA immunohistochemistry as a screening tool for viral encephalitis.

American journal of clinical pathology
2023

West Nile Virus-Induced Drop in Egg Production in Commercial Pekin Duck Breeders.

Avian diseases
2023

Isolation of Flaviviruses and Alphaviruses with Encephalitogenic Potential Diagnosed by Evandro Chagas Institute (Pará, Brazil) in the Period of 1954-2022: Six Decades of Discoveries.

Viruses
2023

Efficacy of a brain-penetrant antiviral in lethal Venezuelan and eastern equine encephalitis mouse models.

Science translational medicine
2023

Evidence of Uranotaenia sapphirina (Diptera: Culicidae) feeding on annelid worms in the Northeastern United States.

Journal of medical entomology
2024

Commonly Reported Mosquito-Borne Viruses in the United States: A Primer for Pharmacists.

Journal of pharmacy practice
2023

Mapping Eastern (EEE) and Venezuelan Equine Encephalitides (VEE) among Equines Using Geographical Information Systems, Colombia, 2008-2019.

Viruses
2023

Inhibitors of the Ubiquitin-Mediated Signaling Pathway Exhibit Broad-Spectrum Antiviral Activities against New World Alphaviruses.

Viruses
2023

Structural constraints link differences in neutralization potency of human anti-Eastern equine encephalitis virus monoclonal antibodies.

Proceedings of the National Academy of Sciences of the United States of America
2023

Automated SSHHPS Analysis Predicts a Potential Host Protein Target Common to Several Neuroinvasive (+)ssRNA Viruses.

Viruses
2023

Antiviral RNAi Response in Culex quinquefasciatus-Derived HSU Cells.

Viruses
2023

Venezuelan equine encephalitis virus E1 protein interacts with PDIA6 and PDI inhibition reduces alphavirus production.

Antiviral research
2023

Co-occurrence probabilities between mosquito vectors of West Nile and Eastern equine encephalitis viruses using Markov Random Fields (MRFcov).

Parasites &amp; vectors
2022

Alphavirus Particles Can Assemble with an Alternate Triangulation Number.

Viruses
2023

Activity, Template Preference, and Compatibility of Components of RNA Replicase of Eastern Equine Encephalitis Virus.

Journal of virology
2022

Update on the distribution of Culiseta melanura in regions of Illinois with prior eastern equine encephalitis virus activity.

Journal of vector ecology : journal of the Society for Vector Ecology
2022

"Parenthesis sign" in Eastern equine encephalitis.

Arquivos de neuro-psiquiatria
2023

Severe Arboviral Neuroinvasive Disease in Patients on Rituximab Therapy: A Review.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2022

Pearls & Oy-sters: Seronegative Eastern Equine Encephalitis in an Immunocompromised Stem Cell Transplant Recipient.

Neurology
2022

Multi-season transmission model of Eastern Equine Encephalitis.

PloS one
2022

Spatiotemporal Environmental Drivers of Eastern Equine Encephalitis Virus in Central Florida: Towards a Predictive Model for a Lethal Disease.

Journal of medical entomology
2022

Efficacy of Western, Eastern, and Venezuelan Equine Encephalitis (WEVEE) Virus-Replicon Particle (VRP) Vaccine against WEEV in a Non-Human Primate Animal Model.

Viruses
2022

Cryo-EM structures of alphavirus conformational intermediates in low pH-triggered prefusion states.

Proceedings of the National Academy of Sciences of the United States of America
2022

North American Arboviruses and White-Tailed Deer (Odocoileus virginianus): Associated Diseases and Role in Transmission.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2022

EGR1 Upregulation during Encephalitic Viral Infections Contributes to Inflammation and Cell Death.

Viruses
2022

Eastern equine encephalitis virus rapidly infects and disseminates in the brain and spinal cord of cynomolgus macaques following aerosol challenge.

PLoS neglected tropical diseases
2022

West Nile Virus and Other Domestic Nationally Notifiable Arboviral Diseases - United States, 2020.

MMWR. Morbidity and mortality weekly report
2022

Piperazinobenzodiazepinones: New Encephalitic Alphavirus Inhibitors via Ring Expansion of 2-Dichloromethylquinazolinones.

ACS medicinal chemistry letters
2022

Structure of SNX9 SH3 in complex with a viral ligand reveals the molecular basis of its unique specificity for alanine-containing class I SH3 motifs.

Structure (London, England : 1993)
2021

Predicting eastern equine encephalitis spread in North America: An ecological study.

Current research in parasitology &amp; vector-borne diseases
2022

Development and Validation of a Colorimetric Reverse Transcriptase Loop-Mediated Isothermal Amplification Assay for Detection of Eastern Equine Encephalitis Virus in Mosquitoes.

Journal of the American Mosquito Control Association
2022

West Nile Virus and Eastern Equine Encephalitis Virus High Probability Habitat Identification for the Selection of Sentinel Chicken Surveillance Sites in Florida.

Journal of the American Mosquito Control Association
2022

Alphavirus Identification in Neotropical Bats.

Viruses
2022

Glycosaminoglycan binding by arboviruses: a cautionary tale.

The Journal of general virology
2022

VLDLR and ApoER2 are receptors for multiple alphaviruses.

Nature
2021

Magnetic resonance imaging, clinicopathologic findings, and clinical progression of a puppy with confirmed Eastern equine encephalitis virus.

The Canadian veterinary journal = La revue veterinaire canadienne
2021

Eastern Equine Encephalitis: Case Series in Southern New England and Review of the Literature.

Neurology. Clinical practice
2021

An Updated Review of the Invasive Aedes albopictus in the Americas; Geographical Distribution, Host Feeding Patterns, Arbovirus Infection, and the Potential for Vertical Transmission of Dengue Virus.

Insects
2022

Ecology of Eastern Equine Encephalitis Virus in the Southeastern United States: Incriminating Vector and Host Species Responsible for Virus Amplification, Persistence, and Dispersal.

Journal of medical entomology
2022

Resurgence of Interest in Eastern Equine Encephalitis Virus Vaccine Development.

Journal of medical entomology
2022

Eastern Equine Encephalitis Virus Taxonomy, Genomics, and Evolution.

Journal of medical entomology
2022

Use of Cervid Serosurveys to Monitor Eastern Equine Encephalitis Virus Activity in Northern New England, United States, 2009-2017.

Journal of medical entomology
2022

Ecology and Epidemiology of Eastern Equine Encephalitis Virus in the Northeastern United States: An Historical Perspective.

Journal of medical entomology
2021

Host Associations of Culex pipiens: A Two-Year Analysis of Bloodmeal Sources and Implications for Arboviral Transmission in Southeastern Virginia.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2021

External quality assessment of molecular testing of 9 viral encephalitis-related viruses in China.

Virus research
2021

Case of fatal eastern equine encephalitis.

IDCases
2022

Exposing cryptic epitopes on the Venezuelan equine encephalitis virus E1 glycoprotein prior to treatment with alphavirus cross-reactive monoclonal antibody allows blockage of replication early in infection.

Virology
2021

Inhibitors of Venezuelan Equine Encephalitis Virus Identified Based on Host Interaction Partners of Viral Non-Structural Protein 3.

Viruses
2021

Active Circulation of Madariaga Virus, a Member of the Eastern Equine Encephalitis Virus Complex, in Northeast Brazil.

Pathogens (Basel, Switzerland)
2021

The Structural Biology of Eastern Equine Encephalitis Virus, an Emerging Viral Threat.

Pathogens (Basel, Switzerland)
2021

Therapeutic alphavirus cross-reactive E1 human antibodies inhibit viral egress.

Cell
2021

Prevalence of arbovirus antibodies in young healthy adult population in Brazil.

Parasites &amp; vectors
2021

West Nile Virus and Other Domestic Nationally Notifiable Arboviral Diseases - United States, 2019.

MMWR. Morbidity and mortality weekly report
2021

Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019.

Emerging infectious diseases
2021

Arboviral diseases and poverty in Alabama, 2007-2017.

PLoS neglected tropical diseases
2021

Seroprevalence of arboviruses in Ecuador: Implications for improved surveillance.

Biomedica : revista del Instituto Nacional de Salud
2021

Fatal Human Infection with Evidence of Intrahost Variation of Eastern Equine Encephalitis Virus, Alabama, USA, 2019.

Emerging infectious diseases
2021

Evaluation of a Methoprene Aerial Application for the Control of Culiseta melanura (Diptera: Culicidae) in Wetland Larval Habitats.

Journal of medical entomology
2021

The utilization of advance telemetry to investigate critical physiological parameters including electroencephalography in cynomolgus macaques following aerosol challenge with eastern equine encephalitis virus.

PLoS neglected tropical diseases
2021

PERK Is Critical for Alphavirus Nonstructural Protein Translation.

Viruses
2021

Review of antiviral peptides for use against zoonotic and selected non-zoonotic viruses.

Peptides
2021

Deadly Neuroinvasive Mosquito-Borne Virus: A Case of Eastern Equine Encephalitis.

The Permanente journal
2021

Homoseongomycin, a compound isolated from marine actinomycete bacteria K3-1, is a potent inhibitor of encephalitic alphaviruses.

Antiviral research
2021

Field Analysis of Biological Factors Associated With Sites at High and Low to Moderate Risk for Eastern Equine Encephalitis Virus Winter Activity in Florida.

Journal of medical entomology
2021

Safety and immunogenicity of an inactivated eastern equine encephalitis virus vaccine.

Vaccine
2021

Designing multivalent immunogens for alphavirus vaccine optimization.

Virology
2021

Eastern Equine Encephalitis Virus in Visibly Affected Ruffed Grouse (Bonasa umbellus) in Michigan, Minnesota, and Wisconsin, USA.

Journal of wildlife diseases
2021

Mosquito Identification From Bulk Samples Using DNA Metabarcoding: a Protocol to Support Mosquito-Borne Disease Surveillance in Canada.

Journal of medical entomology
2021

Proteomic Discovery of VEEV E2-Host Partner Interactions Identifies GRP78 Inhibitor HA15 as a Potential Therapeutic for Alphavirus Infections.

Pathogens (Basel, Switzerland)
2021

Serological evidence of Eastern equine encephalitis circulation in equids in Pará state, Brazil.

Brazilian journal of veterinary medicine
2021

Eastern Equine Encephalitis Virus in Mexican Wolf Pups at Zoo, Michigan, USA.

Emerging infectious diseases
2021

Occupations at risk of contracting zoonoses of public health significance in Québec.

Canada communicable disease report = Releve des maladies transmissibles au Canada
2021

The Alphaviral Capsid Protein Inhibits IRAK1-Dependent TLR Signaling.

Viruses
2021

Host interactions of Aedes albopictus, an invasive vector of arboviruses, in Virginia, USA.

PLoS neglected tropical diseases
2020

A Monovalent and Trivalent MVA-Based Vaccine Completely Protects Mice Against Lethal Venezuelan, Western, and Eastern Equine Encephalitis Virus Aerosol Challenge.

Frontiers in immunology
2021

Individual, household and environmental factors associated with arboviruses in rural human populations, Brazil.

Zoonoses and public health
2021

Physiological and immunological changes in the brain associated with lethal eastern equine encephalitis virus in macaques.

PLoS pathogens
2021

Arbovirus serosurvey (Orthobunyavirus, Flavivirus, and Alphavirus) in a draft horse population from Santa Fe, Argentina (2013-2016).

Archives of virology
2020

Serologic Survey of Mosquito-Borne Viruses in Hunter-Harvested White-Tailed Deer (Odocoileus virginianus), New York State.

The American journal of tropical medicine and hygiene
2021

Eastern Equine Encephalitis Virus: A Scoping Review of the Global Evidence.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2020

Human Antibodies Protect against Aerosolized Eastern Equine Encephalitis Virus Infection.

Cell
2021

Treatment of Viral Encephalitis.

Neurologic clinics
2020

Encephalitis with coinfection by Jamestown canyon virus (JCV) and varicella zoster virus (VZV).

IDCases
2021

Eastern equine encephalitis and use of IV immunoglobulin therapy and high-dose steroids.

Neurology(R) neuroimmunology &amp; neuroinflammation
2020

Eastern Equine Encephalitis Virus Seroprevalence in Maine Cervids, 2012-2017.

The American journal of tropical medicine and hygiene
2020

Phosphatidylethanolamine and Phosphatidylserine Synergize To Enhance GAS6/AXL-Mediated Virus Infection and Efferocytosis.

Journal of virology
2021

Characterization of an alphavirus isolated from a stranded harbor porpoise (Phocoena phocoena) from Alaska.

Virus research
2020

The Immune Response to Eastern Equine Encephalitis Virus Acquired Through Organ Transplantation.

Frontiers in microbiology
2020

Clinical features and laboratory diagnosis of emerging arthropod-transmitted viruses: A Report from the Pan American Society for Clinical Virology Clinical Practice Committee.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
2020

Diagnostic Approach for Arboviral Infections in the United States.

Journal of clinical microbiology
2021

A Review of the Control of Aedes aegypti (Diptera: Culicidae) in the Continental United States.

Journal of medical entomology
2020

Serologic Evidence of Arthropod-Borne Virus Infections in Wild and Captive Ruminants in Ontario, Canada.

The American journal of tropical medicine and hygiene
2020

Coverage of the 2019 Eastern equine encephalitis virus outbreak on news media.

Health promotion perspectives
2020

National Seroprevalence and Risk Factors for Eastern Equine Encephalitis and Venezuelan Equine Encephalitis in Costa Rica.

Journal of equine veterinary science
2020

Comparative pathology study of Venezuelan, eastern, and western equine encephalitis viruses in non-human primates.

Antiviral research
2020

Interactions between the imperiled West Indian manatee, Trichechus manatus, and mosquitoes (Diptera: Culicidae) in Everglades National Park, Florida, USA.

Scientific reports
2020

Immunopathogenesis of alphaviruses.

Advances in virus research
2020

Continuation of Mosquito Surveillance and Control During Public Health Emergencies and Natural Disasters.

MMWR. Morbidity and mortality weekly report
2020

Spatial and temporal expansions of Eastern equine encephalitis virus and phylogenetic groups isolated from mosquitoes and mammalian cases in New York State from 2013 to 2019.

Emerging microbes &amp; infections
2020

Serosurvey of Eastern, Western, and Venezuelan Equine Encephalitis Viruses in Wild Boars (Sus scrofa), Hunting Dogs, and Hunters of Brazil.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2020

A small molecule inhibitor of MyD88 exhibits broad spectrum antiviral activity by up regulation of type I interferon.

Antiviral research
2020

Applications of minimally invasive multimodal telemetry for continuous monitoring of brain function and intracranial pressure in macaques with acute viral encephalitis.

PloS one
2020

Hypervariable Domain of nsP3 of Eastern Equine Encephalitis Virus Is a Critical Determinant of Viral Virulence.

Journal of virology
2020

An Overview of Eastern Equine Encephalitis (EEE).

The Neurohospitalist
2020

Embryo Microinjection Techniques for Efficient Site-Specific Mutagenesis in Culex quinquefasciatus.

Journal of visualized experiments : JoVE
2020

Vaccine Advances against Venezuelan, Eastern, and Western Equine Encephalitis Viruses.

Vaccines
2020

Impact of the Southern Oscillation Index, Temperature, and Precipitation on Eastern Equine Encephalitis Virus Activity in Florida.

Journal of medical entomology
2020

Seasonal Changes of Host Use by Culiseta melanura (Diptera: Culicidae) in Central Florida.

Journal of medical entomology
2020

Cryo-EM structure of eastern equine encephalitis virus in complex with heparan sulfate analogues.

Proceedings of the National Academy of Sciences of the United States of America
2020

Eastern Equine Encephalitis Surveillance and Response, Rhode Island, 2019.

Rhode Island medical journal (2013)
2020

Cases of Eastern equine encephalitis in humans associated with Aedes canadensis, Coquillettidia perturbans and Culiseta melanura mosquitoes with the virus in New York State from 1971 to 2012 by analysis of aggregated published data.

Epidemiology and infection
2020

Patterns of mosquito and arbovirus community composition and ecological indexes of arboviral risk in the northeast United States.

PLoS neglected tropical diseases
2020

Encephalitic Alphaviruses Exploit Caveola-Mediated Transcytosis at the Blood-Brain Barrier for Central Nervous System Entry.

mBio
2020

Association of Human Eastern Equine Encephalitis With Precipitation Levels in Massachusetts.

JAMA network open
2020

Notes from the Field: Multistate Outbreak of Eastern Equine Encephalitis Virus - United States, 2019.

MMWR. Morbidity and mortality weekly report
2019

Eastern Equine Encephalitis Virus - Another Emergent Arbovirus in the United States.

The New England journal of medicine
2019

Cooperativity between the 3' untranslated region microRNA binding sites is critical for the virulence of eastern equine encephalitis virus.

PLoS pathogens
2019

Cerebral Organoid Models for Neurotropic Viruses.

ACS infectious diseases
2019

Five Emerging Neuroinvasive Arboviral Diseases: Cache Valley, Eastern Equine Encephalitis, Jamestown Canyon, Powassan, and Usutu.

Seminars in neurology
2019

First Detection of Madariaga virus in Mosquitoes Collected in a Wild Environment of Northeastern Argentina.

The American journal of tropical medicine and hygiene
2018

Evaluation of Partially Submerged Sticky Traps On Lake Spillways For Adult Black Fly (Diptera: Simuliidae) Surveillance and Arbovirus Detection.

Journal of the American Mosquito Control Association
Ver todos os 392 no EuropePMC

Associações

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Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Ainda não achamos doenças com sintomas parecidos o suficiente.

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Observations of the developmental stages of Coquillettidia perturbans (Diptera: Culicidae) with special reference to the pupal trumpets.
    Journal of insect science (Online)· 2026· PMID 41804670mais citado
  2. Isolation of Madariaga Virus (MADV) in a Horse Coinfected with Equine Infectious Anemia in Venezuela: A Review of MADV Circulation in the Country.
    Veterinary sciences· 2026· PMID 41600727mais citado
  3. Investigation of neurotropic arboviruses in wild and domestic animals in Amazon region, 2023-2024.
    Memorias do Instituto Oswaldo Cruz· 2026· PMID 41849539mais citado
  4. Impact of mutations affecting 4'-fluorouridine susceptibility on fitness and treatment outcomes for Venezuelan equine encephalitis virus.
    Journal of virology· 2026· PMID 41537597mais citado
  5. MOSQUITO SPECIES OF NEW YORK STATE: AN UPDATED CHECKLIST WITH PUBLIC AND VETERINARY HEALTH SIGNIFICANCE.
    Journal of the American Mosquito Control Association· 2026· PMID 41213512mais citado
  6. Linking hosts, landscapes, and climate to advance zoonotic arbovirus forecasting.
    Sci Rep· 2026· PMID 41942586recente
  7. Enhanced efficacy of a next-generation EEEV self-replicating RNA platform for combination cancer immunotherapies.
    Mol Ther· 2026· PMID 41889175recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:83594(Orphanet)
  2. MONDO:0005736(MONDO)
  3. GARD:10821(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q18553951(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Encefalite equina oriental
Compêndio · Raras BR

Encefalite equina oriental

ORPHA:83594 · MONDO:0005736
Prevalência
Unknown
Herança
Not applicable
CID-10
A83.2 · Encefalite eqüina oriental
CID-11
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0153065
EuropePMC
Wikidata
Wikipedia
Papers 10a
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