Um perineurioma geralmente benigno, não associado a um nervo, que se origina nos tecidos moles.
Introdução
O que você precisa saber de cara
Um perineurioma geralmente benigno, não associado a um nervo, que se origina nos tecidos moles.
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Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
2 genes identificados com associação a esta condição.
Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like g
Cell membraneSecretedCytoplasm, cytosol
Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells (PubMed:27789576). Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide
CytoplasmCell projection, podosome
Variantes genéticas (ClinVar)
160 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
3 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Perineurioma
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
The PERISCOPE Cohort: A Retrospective Study of Clinicopathological and TRAF7 Genetic Findings in Intraneural Perineurioma.
Intraneural perineurioma (INP) is a rare, benign peripheral nerve sheath tumour that typically presents in adolescence or early adulthood as a slowly progressive, motor-predominant mononeuropathy or plexopathy. Although its clinicoradiological and histopathological features are well characterised, the genetic basis remains incompletely defined. We retrospectively analysed 10 patients with histologically confirmed INP diagnosed between February 2015 and December 2024. Demographic and clinical data, MRI/MR neurography findings and histopathology (immunohistochemistry and electron microscopy) were analysed. Targeted Sanger sequencing of TRAF7 exons 17-18 (WD40 domain) was performed. Interphase FISH with an EWSR1 (22q12) probe was performed on archival FFPE tissue in a subset. All patients exhibited progressive motor deficits, with at least one muscle group graded ≤ 2 on the MRC scale. Sensory symptoms were present in 8/10 and pain in 4/10. MRI demonstrated fusiform nerve enlargement and homogeneous gadolinium enhancement in all cases, with T2 hyperintensity in 9/10. A pathogenic TRAF7 p.His521Arg variant was identified in 2/9 evaluable tumours (22.2%). Tendon transfer was performed in 7/10 patients as a reconstructive strategy to improve motor function, resulting in heterogeneous functional outcomes. The MRI triad of fusiform enlargement, T2 hyperintensity and homogeneous enhancement strongly supports INP diagnosis and may obviate biopsy in typical cases. Our hotspot-limited assay detected TRAF7 mutations in only 22.2%, underscoring methodological limitations and probable genetic heterogeneity. Despite an indolent imaging appearance, INP frequently causes severe functional impairment requiring reconstructive surgery. Early recognition, structured functional monitoring and risk-adapted intervention are essential to optimise outcomes.
An Unsuspected Intraneural Perineurioma in a Pediatric Patient: A Case Report.
Perineuriomas are rare tumors arising from perineurial cells that form the protective layer surrounding peripheral nerve fascicles. Four types of perineuriomas have been described: (i) intraneural, (ii) soft tissue (extraneural), (iii) sclerosing, and (iv) mucosal. Intraneural perineuriomas are rarely reported nerve sheath tumors that primarily affect the peripheral nerves of the upper and lower extremities. In this report, we present a pediatric case in which the diagnosis of perineurioma was not suspected until lesional tissue was obtained, and the final pathologic diagnosis was made. The patient is a 17-year-old girl who presented with a three-year history of symptoms involving the left upper extremity, including weakness and cramping, which became progressively worse over time. Diagnostic workup included magnetic resonance imaging (MRI), which showed enlargement and contrast enhancement of two of the left brachial plexus nerve trunks, suggestive of an inflammatory or infectious etiology, with schwannoma or neurofibroma also listed as less likely possibilities. An electromyogram (EMG) showed findings concerning for an anterior horn cell process, including amyotrophic lateral sclerosis (ALS). Nerve conduction studies (NCS) demonstrated axonal findings only in motor nerves, and needle EMG demonstrated denervation and fasciculations in multiple muscles. An initial biopsy of the brachial plexus was performed but was non-diagnostic. Ultimately, resection of the involved nerve trunks was performed. The diagnosis of intraneural perineurioma was not suspected preoperatively and was made only after histologic and immunohistochemical examination.
Cutaneous Perineurioma of the Medial Superciliary Arch: An Uncommon Location for a Rare, Benign Spindle Cell Neoplasm.
Cutaneous perineuriomas are rare, benign peripheral nerve sheath tumors that are often mistaken for other adnexal or spindle cell lesions, with facial involvement being uncommon. Recognition is important to ensure accurate diagnosis and avoid unnecessary overtreatment. We report a case of a 36-year-old Hispanic woman with a slowly enlarging papule of the left medial superciliary arch, histologically and immunophenotypically confirmed as a cutaneous perineurioma. This case highlights the clinicopathologic features, immunohistochemical profile, and management considerations of cutaneous perineurioma arising in a rare, cosmetically sensitive facial location, adding to the limited body of published cases.
Benign cutaneous plexiform hybrid tumour of perineurioma and cellular neurothekeoma: A rare diagnosis.
Benign cutaneous plexiform hybrid tumour of perineurioma and cellular neurothekeoma (BCPHTPCN) is an uncommon mesenchymal tumour first described in 2013, characterised by mixed features of perineurioma and cellular neurothekeoma. Clinically, it presents as a small papule, most frequently located in the perioral region. Histologically, it displays a plexiform pattern composed of epithelioid and spindle cells within a myxoid stroma, together with a hybrid immunohistochemical profile. In this article, we describe the case of an 82-year-old woman presenting with a perioral nodule clinically suspected to be a basal cell carcinoma, whose histological and immunohistochemical findings confirmed the diagnosis of BCPHTPCN. The tumour's features, differential diagnoses, and the need for further studies to better define its clinicopathological spectrum are discussed.
Hybrid Nerve Sheath Tumor Detected by Endoscopic Full-Thickness Resection for a Gastric Subepithelial Lesion: A Case Report.
Hybrid nerve sheath tumors (HNSTs) are exceedingly rare in the gastrointestinal tract, particularly in the stomach. We describe a case of an enlarging gastric subepithelial lesion (SEL) that was accurately diagnosed and curatively treated by endoscopic full-thickness resection (EFTR). A 50-year-old woman presented with a 10 mm SEL on the posterior wall of the upper gastric curvature. Endoscopic ultrasound (EUS) revealed a low-hypoechoic lesion primarily originating from the third layer with focal, indistinct borders with the muscularis propria. Initial boring biopsy suggested a granular cell tumor based on morphology and SOX10/S100 positivity. Six months later, the lesion had enlarged to 15 mm, and EFTR under general anesthesia with laparoscopic backup was selected to obtain a full-thickness specimen. En bloc resection was successfully achieved, and the defect was completely closed with clips. Histopathological and immunohistochemical examinations revealed biphasic Schwann and perineurial differentiation, confirming a hybrid schwannoma/perineurioma. The postoperative course was uneventful, and no recurrence was observed during the 22-month follow-up. This case highlights the diagnostic value of EFTR for rare neurogenic SELs in which superficial biopsy may be inconclusive.
Publicações recentes
Gastric perineurioma detected in routine endoscopy biopsy practice: case report and review of clinico-pathological findings in the literature.
Novel perineurioma-like soft tissue tumour with SETD1A::FOSB fusion.
An Unsuspected Intraneural Perineurioma in a Pediatric Patient: A Case Report.
Cutaneous Perineurioma of the Medial Superciliary Arch: An Uncommon Location for a Rare, Benign Spindle Cell Neoplasm.
📚 EuropePMC329 artigos no totalmostrando 197
An Unsuspected Intraneural Perineurioma in a Pediatric Patient: A Case Report.
CureusCutaneous Perineurioma of the Medial Superciliary Arch: An Uncommon Location for a Rare, Benign Spindle Cell Neoplasm.
CureusThe PERISCOPE Cohort: A Retrospective Study of Clinicopathological and TRAF7 Genetic Findings in Intraneural Perineurioma.
European journal of neurologyBenign cutaneous plexiform hybrid tumour of perineurioma and cellular neurothekeoma: A rare diagnosis.
Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de CitologiaHybrid Nerve Sheath Tumor Detected by Endoscopic Full-Thickness Resection for a Gastric Subepithelial Lesion: A Case Report.
DEN openSclerosing perineurioma of the anterior chest wall in an active Caucasian toddler: a case report.
Translational pediatricsOrbital soft-tissue perineurioma.
Journal francais d'ophtalmologieDistinct Imaging Features of Peripheral Nerve Sheath Tumours in NF2-Related Schwannomatosis: A Case Report.
Case reports in neurological medicineExtraneural Soft Tissue Perineurioma of the Oral Cavity: A Rare Case with Medico-Legal Implications and Literature Review.
Life (Basel, Switzerland)Beyond Hybrid Morphology: A Large Series of Fusion-Driven Benign Peripheral Nerve Sheath Tumors Including 5 Tumors With Novel Fusions.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncUtility of ultrasound in the diagnosis and management of a radial nerve perineurioma in a pediatric patient.
Surgical neurology internationalPerineuriomatous Nevus: A New Case Presentation With a Brief Review of the Literature.
The American Journal of dermatopathologyThe Role of Ultrasound in the Diagnosis of Intraneural Perineurioma.
Muscle & nerveGastrointestinal Tract Perineuriomas and Benign Fibroblastic Polyps: Case Report and Comprehensive Systematic Review.
Case reports in gastrointestinal medicineHybrid Benign Peripheral Nerve Sheath Tumors: A Comprehensive Literature Review with Emphasis on Their Clinical, Morphological and Genetic Features.
Diagnostics (Basel, Switzerland)A Case of Perineurioma Recurring in the Mandible.
Journal of plastic and reconstructive surgeryHybrid granular cell tumor/perineurioma: a report of two rare cases with PIK3CA mutations.
Virchows Archiv : an international journal of pathologyEpithelial-Stromal Polyp With Features of Perineurioma Lacking Covering Serrated Crypts Associated With a Sessile Serrated Lesion With High-Grade Dysplasia of the Colon: A Case Report.
CureusNeural or Neural-Related Colorectal Lesion Incidence Varies by Site, and Multifocal Cases Are Often Syndromic: Insights From a Series of 593 Patients.
Archives of pathology & laboratory medicineIntraneural Pseudoperineuriomatous Proliferations and Traumatic Neuromas: A Retrospective Multicenter Study of Clinicopathological Characteristics.
Head and neck pathologyHybrid nerve sheath tumor of the spinal canal and neurofibromatosis-2, where the twain shall meet-a case report and review of literature.
Journal of medical case reportsA Case of Hybrid Cellular Neurothekeoma and Perineurioma With a Folliculin Gene Mutation.
Journal of cutaneous pathologyHybrid peripheral nerve sheath tumours - A Review.
Journal of oral and maxillofacial pathology : JOMFPGlucose Transporter 1 (GLUT1) Positivity in Ganglion Cysts: A Diagnostic Caveat Due to Overlap With Perineuriomas and Other Fibromyxoid Lesions.
CureusAcral Cutaneous Intraneural Pseudoperineurioma.
The American Journal of dermatopathologyHybrid Epithelioid Schwannoma/Neurofibroma: A Report of 3 Cases.
The American Journal of dermatopathologyEndobronchial ultrasound-guided cryobiopsy of a rare epicardial tumour.
PulmonologyMale breast perineurioma: a rare presentation.
BMJ case reportsA Rare Case of Perineurioma of the Posterior Interosseous Nerve: A Case Report.
CureusGastrointestinal stromal tumor mimicking perineurioma: A case report.
CytoJournalGastric perineurioma: a rare entity with different clinical presentations. A case report.
Journal of gastrointestinal and liver diseases : JGLDExtraneural Soft Tissue Perineurioma: A Report of a Rare Case of Peripheral Nerve Sheath Tumor.
CureusPerineuriomatous Melanocytic Nevi: A Case Series of Four Cases.
Journal of cutaneous pathologyPseudolipoblastic Perineuroma: A Rare Histologi̇c Subtype.
The American Journal of dermatopathologyRare Hybrid Perineurioma and Granular Cell Tumor: A Pediatric Case.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyEMA-Positive Superficial ALK-Rearranged Myxoid Spindle Cell Neoplasm Masquerading as Perineurioma/Hybrid Nerve Sheath Tumor.
The American Journal of dermatopathologyCollection of Rare Peripheral Nerve Tumors-Insights from the German Registry.
CancersSclerosing Perineurioma of the Orbit.
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Human pathologyFeasibility study of ResNet-50 in the distinction of intraoral neural tumors using histopathological images.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral PathologySurgical treatment of perineurioma involving both the intramedullary and extramedullary nerve roots in the cervical spine.
Asian journal of surgeryMalignant perineurioma derived from the retroperitoneum with an aggressive clinical course: a case report.
Surgical case reportsSmall intestinal obstruction caused by perineurioma: A case report and review of literature.
Asian journal of surgeryA 22-year-old man with a posterior left shoulder mass.
Skeletal radiologyCutaneous Syncytial Myoepithelioma: An Uncommon and Distinct Variant of Cutaneous Epithelioid Neoplasm.
The American Journal of dermatopathologyUtility of LEF1 to differentiate desmoid fibromatosis from its histologic mimics.
Virchows Archiv : an international journal of pathologyTreatment of childhood intraneural perineurioma: A case report and literature review.
HeliyonIntramuscular Hybrid Nerve Sheath Tumor of the Thigh: Case Report and Literature Review.
In vivo (Athens, Greece)Gastric Perineurioma: A Rare Entity with Molecular Analysis and Literature Review.
International journal of surgical pathologyCase report: Intraneural perineurioma in dogs: a case series and brief literature review.
Frontiers in veterinary scienceHybrid peripheral nerve sheath tumours: MRI features with pathological correlation in 24 cases.
The British journal of radiologyCytological features of cranial and paraspinal nerve Tumours.
Cytopathology : official journal of the British Society for Clinical CytologyCYP1A1 immunohistochemistry is highly specific for angiofibroma of soft tissue among morphological mimics.
HistopathologyHybrid Schwannoma/Neurofibroma of the Neck: A Case Report.
Ear, nose, & throat journalWhat is new in intraneural perineurioma?
Acta neurochirurgicaBenign peripheral nerve sheath tumors: an interdisciplinary diagnostic and therapeutic challenge.
Neurosurgical reviewPerineurioma Diagnosed After Endoscopic Treatment of Suspected Gastric Adenocarcinoma of the Fundic Gland.
ACG case reports journalHybrid Schwannoma-Perineurioma of the Orbit.
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Seminars in diagnostic pathologySuperficial mesenchymal tumours expressing epithelial markers on immunohistochemistry: Diagnostic clues and pitfalls.
Seminars in diagnostic pathologyDiagnosis and Treatment of Peripheral and Cranial Nerve Tumors with Expert Recommendations: An EUropean Network for RAre CANcers (EURACAN) Initiative.
CancersMyxoid perineurioma: an entity with many mimics.
Dermatology online journalPerineurioma of the sciatic nerve with reticular, microcystic, and pseudolipoblastic features: illustrative case.
Journal of neurosurgery. Case lessonsMicroreticular perineurioma: A new morphological subtype of a rare entity.
Journal of cutaneous pathologyEpithelioid perineurioma of the vulva: A case report.
The Journal of dermatologyGAB1::ABL1 fusions define a distinctive soft tissue neoplasm, with variable perineurial differentiation, and a predilection for children and young adults.
Genes, chromosomes & cancerAssessing the role of sodium fluorescein in peripheral nerve sheath tumors and mimicking lesions surgery: An update after 142 cases.
Frontiers in oncologyUltrasonography of peripheral nerve tumours: a case series.
Radiology and oncologyBenign peripheral nerve tumors: Analysis of 89 FNA cases emphasizing diagnostic accuracy and their morphologic spectrum.
Cancer cytopathologyColonic perineurioma of the transverse colon: presentation of a rare neoplasm in an atypical location.
Revista espanola de enfermedades digestivasSurgical Management of Peripheral Nerve Pathology in Patients With Neurofibromatosis Type 2.
NeurosurgeryPlexal intraneural perineurioma: an analysis of the clinicoradiologic presentation of this rare variant.
Acta neurochirurgicaHybrid tumors with perineurioma components: a systematic review of the literature and illustrative case.
Acta neurochirurgicaLetter to Editor Regarding "Hybrid Neurofibroma/Schwannoma of the Oral Cavity: A Rare Case Report and Literature Review" by Leite et al.
International journal of surgical pathologyA Rare Case of Bladder Perineurioma.
CureusSclerosing Perineurioma: a Rare Cause of Thumb Mass.
Journal of general internal medicineRecurrent VGLL3 fusions define a distinctive subset of spindle cell rhabdomyosarcoma with an indolent clinical course and striking predilection for the head and neck.
Genes, chromosomes & cancerRREB1::MRTFB fusion-positive extra-glossal mesenchymal neoplasms: A series of five cases expanding their anatomic distribution and highlighting significant morphological and phenotypic diversity.
Genes, chromosomes & cancerPractical Approach to Histological Diagnosis of Peripheral Nerve Sheath Tumors: An Update.
Diagnostics (Basel, Switzerland)Benign Cutaneous Plexiform Hybrid Tumor Composed of Agminated Perineurioma and Cellular Neurothekeoma Components in a 9-Month-Old Boy.
Actas dermo-sifiliograficasGastric Perineurioma: A Case Report and Review of the Literature.
International journal of surgical pathologyHistopathological and Immunohistochemical Evaluation of Canine Nerve Sheath Tumors and Proposal for an Updated Classification.
Veterinary sciencesSclerosing perineurioma: a rare benign tumor in a pediatric patient.
Dermatology online journalAcral perineurioma: A case report of a rare neoplasm successfully treated with autologous skin graft reconstructive surgery.
Dermatology reportsA Rare case of Ulnar Nerve Intraneural Perineurioma in an elderly gentleman.
JPRAS openUnilateral Cavovarus Foot From Sciatic Nerve Perineurioma.
Neurology IndiaClinicopathologic and Molecular Study of Hybrid Nerve Sheath Tumors Reveals Their Common Association With Fusions Involving VGLL3.
The American journal of surgical pathologyPediatric Soft Tissue Perineurioma in the Head and Neck.
Ear, nose, & throat journalClinical, pathologic, and molecular analyses of superficial low-grade fibromyxoid sarcoma in two young patients: A rare and deceptive mimic of benignancy.
Journal of cutaneous pathologyPort-Wine Stain and Monomelic Weakness Associated With Perineurioma: A Neuromuscular Image.
Journal of clinical neuromuscular diseaseMorphological Relation of Peripheral Nerve Sheath Tumors and Nerve Fascicles: Prospective Study and Classification.
Journal of clinical medicine[Sclerosing perineurioma of the left hand middle finger: report of a case].
Zhonghua bing li xue za zhi = Chinese journal of pathologySoft tissue perineurioma involving the kidney: a report of two cases with an emphasis on differential diagnosis.
Diagnostic pathologyNerve conduction assessment and magnetic resonance imaging for the diagnosis of localized hypertrophic neuropathy of the sciatic nerve and the lumbo-sacral plexus.
Clinical neurology and neurosurgeryUpdate on Peripheral Nerve Sheath Tumors in Upper Extremity: A Descriptive Review.
The journal of hand surgery Asian-Pacific volumeMesenchymal PLAG1 Tumor With PCMTD1-PLAG1 Fusion in an Infant: A New Type of "Plagoma".
The American Journal of dermatopathologyClinical Features, Natural History, and Outcomes of Intraneural Perineuriomas: A Systematic Review of the Literature.
World neurosurgeryA Solitary Sigmoid Perineurioma in an Otherwise Healthy 30-Year-Old Male.
CureusTrigeminal hybrid nerve sheath tumor - a case report and literature review.
British journal of neurosurgeryExtraneural Sclerosing Perineurioma of the Tongue.
Ear, nose, & throat journalPerineurioma: A Rare Entity of Peripheral Nerve Sheath Tumors.
Journal of neurological surgery. Part A, Central European neurosurgeryBenign cutaneous plexiform hybrid tumor of perineurioma and cellular neurothekeoma on the leg.
The Journal of dermatologyEyelid-Cheek Junction Soft-Tissue Perineurioma: Case Report and Controversies.
Ophthalmic plastic and reconstructive surgeryPerineuriomatous nevi: A series of eight cases highlighting unifying pathologic features to avoid misdiagnosis.
Journal of cutaneous pathology[Intra-oral Perineurioma, a case report].
Nederlands tijdschrift voor tandheelkundeHybrid schwannoma-perineurioma frequently harbors VGLL3 rearrangement.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, IncSporadic Malignant Perineurioma: A Rare Diagnosis Among Malignant Peripheral Nerve Sheath Tumors.
World neurosurgeryIntraneural perineurioma of the median nerve at the elbow: A clinical case.
Hand surgery & rehabilitationCap-assisted Endoscopic Mucosal Resection of Rectal Perineurioma Mimicking a Neuroendocrine Tumor.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chiDiagnostic Pathology of Tumors of Peripheral Nerve.
NeurosurgeryFrom Dyspepsia to Diagnosis: A Rare Gastric Subepithelial Lesion Definitively Diagnosed via Endoscopic Submucosal Dissection and Immunohistochemistry.
The Permanente journalIntrinsic peripheral nerve and root tumor and pseudotumoral lesions at a tertiary care pediatric hospital.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryHybrid Schwannoma/Perineurioma: Morphologic Variations and Genetic Profiles.
Applied immunohistochemistry & molecular morphology : AIMMPerineurioma versus meningioma. A multi-institutional immunohistochemical and ultrastructural studY.
Ultrastructural pathologyEpithelial-Stromal Polyps of the Colon Are Not Perineuriomas.
American journal of clinical pathologyPeripheral nerve tumors of the hand: Clinical features, diagnosis, and treatment.
World journal of clinical casesPeripheral Nerve Sheath Tumors of Head and Neck: Imaging-Based Review of World Health Organization Classification.
Journal of computer assisted tomographyOrbital hybrid peripheral nerve sheath tumors.
Taiwan journal of ophthalmology[Informative value of ultrasound in the diagnosis of intraneural perineurioma].
Zhurnal voprosy neirokhirurgii imeni N. N. BurdenkoOrbital hybrid schwannoma/perineurioma: A case presentation.
Pathology internationalPrimary intra-osseous Hybrid Schwannoma-Perineurioma in the mandible.
Journal of clinical and experimental dentistry[Intraneural perineurioma of the radial nerve in the spiral canal as the cause of a 6-year progressive paresis of hand and finger extension].
Der NervenarztIntraneural perineurioma of the mandible: case series of a rare entity.
Oral surgery, oral medicine, oral pathology and oral radiologyRecurrent Fusion of the GRB2 Associated Binding Protein 1 (GAB1) Gene With ABL Proto-oncogene 1 (ABL1) in Benign Pediatric Soft Tissue Tumors.
Cancer genomics & proteomicsFacial Nerve Intraneural Perineurioma Masquerading as a Schwannoma.
JAMA otolaryngology-- head & neck surgeryIntraneural perineurioma with thenar atrophy presenting as congenital absence of thenar muscles.
Clinical anatomy (New York, N.Y.)Supraclavicular Solitary Hybrid Schwannoma/Neurofibroma: A Case Report.
CureusAssociation of intraneural perineurioma with neurofibromatosis type 2.
Acta neurochirurgicaLimb Undergrowth in Intraneural Perineuriomas: An Under-Recognized Association.
World neurosurgeryOnychomatricoma Presenting as a Dystrophic Right Great Toenail: Case Report and Review.
CureusEndoscopic Mucosal Resection of a Gastric Perineurioma.
ACG case reports journalIntramucosal true perineurioma of the sigmoid: endoscopic and pathological features of an infrequent lesion.
EndoscopyIntraneural perineurioma in neurofibromatosis type 2 with molecular analysis.
Clinical neuropathologyPenile pacinian neurofibroma.
Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de CitologiaDecision Making in Retroperitoneal Nerve Sheath and Nerve-Associated Tumors: A Modular Approach.
NeurosurgeryModern treatment of perineuriomas: a case-series and systematic review.
BMC neurologyA Rare Perineurioma/Granular Cell Tumor Hybrid Peripheral Nerve Sheath Tumor.
The American Journal of dermatopathologyPerineurioma -a rare cause of proptosis.
Orbit (Amsterdam, Netherlands)Novel case of hybrid perineurioma-neurofibroma of the orbit.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologieThe differential diagnosis between sclerotic fibroma and sclerosing perineurioma: An unresolved challenge.
Journal of cutaneous pathologyWhat's new in nerve sheath tumors.
Virchows Archiv : an international journal of pathologySpindle cell proliferations of the sigmoid colon, rectum and anus: a review with emphasis on perineurioma.
HistopathologySodium Fluorescein as Intraoperative Visualization Tool During Peripheral Nerve Biopsies.
World neurosurgery[Hybrid schwannoma/perineurioma: a clinicopathological analysis of 35 cases].
Zhonghua bing li xue za zhi = Chinese journal of pathologyColonic Perineurioma's Malignant Proximity to Serrated Colonic Polyps.
CureusIntraneural granular cell tumor: Histologic spectrum and histogenetic implication.
Journal of cutaneous pathologyExtraneural perineurioma: CT and MRI imaging characteristics.
Skeletal radiologyPrimary intraosseous hybrid epithelioid schwannoma/perineurioma in the proximal tibia: a case report of benign hybrid neoplasm with local hypercellularity.
Diagnostic pathologyIntramucosal fat is uncommon in large bowel polyps but raises three differential diagnoses.
Journal of clinical pathologyGastric hybrid schwannoma/perineurioma.
Cirugia espanolaAtypical Endoscopic Findings of Rectal Perineurioma.
Internal medicine (Tokyo, Japan)Perineurioma of the Tongue: A Case Report and Review of the Literature.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial SurgeonsIntraneural perineurioma: a retrospective study of 19 patients.
The Pan African medical journalPerineurioma of the colon: an uncommon tumor with an unusual location. Report of a case and review of the literature.
PathologicaMucosal Schwann Cell Hamartoma of the Rectosigmoid Junction: A Rare Lesion Mimicking Mucosal Prolapse Syndrome and Other Neural Lesions.
International journal of surgical pathologyA wolf in sheep's clothing: a benign perineurioma-like lesion that is not what it seems.
Singapore medical journalClinical and Radiological Follow-up of Intraneural Perineuriomas.
NeurosurgeryRecurrent Genomic Alterations in Soft Tissue Perineuriomas.
The American journal of surgical pathologyPerineurioma of the sigmoid colon.
BMJ case reportsIntraosseous intraneural perineurioma derived from the inferior alveolar nerve with an abnormality of chromosome 22 and expression of the BCR-ABL fusion gene: report of a case and review of recent literature.
World journal of surgical oncologyLow-fat, plexiform spindle cell lipoma of the lip expressing S100 protein: a neural tumor simulator.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieSerrated epithelial colorectal polyps (hyperplastic polyps, sessile serrated adenomas) with perineurial stroma: Clinicopathological and molecular analysis of a new series.
Annals of diagnostic pathologyLarge polypoid perineurioma of the transverse colon without crypt serration (NPS).
International journal of clinical and experimental pathologyLeft Supraclavicular Swelling: Sclerosing Perineurioma.
The Eurasian journal of medicineReconstruction of the Shoulder Joint with a Custom-Made Ceramic Implant After a Total Scapulectomy: A Case Report.
JBJS case connectorMultiple perineuriomatous melanocytic nevi.
Journal of cutaneous pathologyColonic perineurioma (benign fibroblastic polyp): case report and review of the literature.
Diagnostic pathologyBenign Cutaneous Peripheral Nerve Sheath Tumor with Hybrid Features: Report of Two Cases with Schwannoma/Perineurioma and Schwannoma/Neurofibroma Components.
Dermatopathology (Basel, Switzerland)A Perineurioma Treated With Mohs Micrographic Surgery.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]Low-grade fibromyxoid sarcoma arising within the median nerve.
Neuropathology : official journal of the Japanese Society of NeuropathologyAnesthesia for a parturient with intraneural perineurioma: A case report.
MedicineClinicoradiological features of intraneural perineuriomas obviate the need for tissue diagnosis.
Journal of neurosurgeryA Sclerosing Perineurioma With Collagen Rosette Formation: Benign Mimic of Low-Grade Fibromyxoid Sarcoma.
International journal of surgical pathologyIntraneural perineuriomas: diagnostic value of magnetic resonance neurography.
Journal of the peripheral nervous system : JPNSSoft Tissue Perineurioma in a Child With Neurofibromatosis Type 1: A Case Report and Review of the Literature.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyHybrid peripheral nerve sheath tumors: A review.
Ceskoslovenska patologieHybrid peripheral nerve sheath tumors: report of five cases and detailed review of literature.
BMC cancerGastric perineurioma: clinicopathological characteristics.
PathologyPrimary Extracranial Meningioma: A Rare Location.
Head and neck pathologySpontaneous spinal plexiform perineurioma in a juvenile chicken ( Gallus domesticus).
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, IncWhorling cellular perineurioma: A previously undescribed variant closely mimicking monophasic fibrous synovial sarcoma.
Annals of diagnostic pathologyIntranodal meningothelial proliferation in a patient with Cowden syndrome: a case report.
Human pathologyTeaching NeuroImages: Sonographic detection of intraneural perineurioma in therapy-refractory carpal tunnel syndrome.
NeurologyTargeted fascicular biopsy of the brachial plexus: rationale and operative technique.
Neurosurgical focusCan Intraneural Perineuriomas Occur Intradurally? An Anatomic Perspective.
NeurosurgerySclerosing Dermatofibrosarcoma Protuberans Shows Significant Overlap With Sclerotic Fibroma in Both Routine and Immunohistochemical Analysis: A Potential Diagnostic Pitfall.
The American Journal of dermatopathologyExtra-acral cutaneous sclerosing perineurioma with CD34 fingerprint pattern.
Journal of cutaneous pathologyOral perineurioma: clinicopathologic features from two cases and review of literature.
Oral surgery, oral medicine, oral pathology and oral radiologyGenomic analysis reveals frequent TRAF7 mutations in intraneural perineuriomas.
Annals of neurologyReticular Perineurioma of the Hand: Diagnosis and Treatment of a Rare Case of Hand Mass.
The Journal of hand surgeryProtein gene product 9.5 (PGP9.5) expression in benign cutaneous mesenchymal, histiocytic, and melanocytic lesions: comparison with cellular neurothekeoma.
PathologyBroadening the Anatomic Landscape of Sclerosing Perineurioma: A Series of 5 Cases in Nonacral Sites.
The American Journal of dermatopathologyIntraoral Pseudo-Onion Bulb Intraneural Proliferations in a Patient with Hemimandibular Hyperplasia: A Case Report and Review of the Literature.
Head and neck pathologyPseudolipoblastic perineurioma: an unusual morphological variant of perineurioma that may simulate liposarcoma.
Human pathologyIntratemporal Intraneural Perineurioma of the Facial Nerve.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyCase report: Intraneural perineurioma of the sciatic nerve in an adolescent - strategies for revealing the diagnosis.
Clinical case reportsAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- The PERISCOPE Cohort: A Retrospective Study of Clinicopathological and TRAF7 Genetic Findings in Intraneural Perineurioma.
- An Unsuspected Intraneural Perineurioma in a Pediatric Patient: A Case Report.
- Cutaneous Perineurioma of the Medial Superciliary Arch: An Uncommon Location for a Rare, Benign Spindle Cell Neoplasm.
- Benign cutaneous plexiform hybrid tumour of perineurioma and cellular neurothekeoma: A rare diagnosis.Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de Citologia· 2026· PMID 41547237mais citado
- Hybrid Nerve Sheath Tumor Detected by Endoscopic Full-Thickness Resection for a Gastric Subepithelial Lesion: A Case Report.
- Gastric perineurioma detected in routine endoscopy biopsy practice: case report and review of clinico-pathological findings in the literature.
- Novel perineurioma-like soft tissue tumour with SETD1A::FOSB fusion.
- Perineurioma.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:85102(Orphanet)
- MONDO:0019404(MONDO)
- GARD:12698(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q1314058(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
