Doença de Paget extramamária

Trastuzumab Rezetecan in Advanced Solid Tumors Refractory to Standard Therapies

NCT07309770

A Study of Disitamab Vedotin + Bicalutamide in HER2/AR-Positive Scrotal Paget's Disease

NCT07117851

A Study of Fluorescein Sodium in People Undergoing Vulvectomy for Extramammary Paget's Disease (EMPD)

NCT06873815

A Study of RC48-ADC Combined With JS001 for Advanced Extramammary Paget Disease of the Scrotum

NCT06791070

Multi-cohort, Single-arm Phase II Study of Albumin-paclitaxel, Ifosfamide, and Cisplatin in the Treatment of Rare Advanced Tumors

NCT06684327

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Publicações mais relevantes

Timeline de publicações

345 papers (10 anos)

#1

Efficacy of Radiation Therapy in 106 Patients with Extramammary Paget Disease: A Retrospective Study.

Advances in radiation oncology2026 Apr

Extramammary Paget disease (EMPD) is rare among Asians, and the clinical value of radiation therapy for EMPD remains controversial. This retrospective study evaluated the efficacy of radiation therapy for EMPD. From January 2012 to December 2021, 106 patients with pathologically confirmed EMPD with complete follow-up data were treated at Peking University First Hospital. The primary treatment was surgery combined with adjuvant radiation therapy, with radical radiation therapy for inoperable patients. The main surgical method for the primary lesion was Mohs micrographic surgery, with a few patients undergoing wide local excision. The recommended postoperative and radical radiation therapy doses were 50 to 60 Gy and 60 to 70 Gy, respectively. The primary endpoint was disease-specific survival rate; secondary endpoints included local recurrence-free survival, lymph node metastasis, and distant metastasis rates. Survival rates were determined using the Kaplan-Meier method and tested with the log-rank test. Univariate and multivariate prognostic analyses were performed using the Cox regression model. The study population comprised 90 men and 16 women (male-to-female ratio, 5.6:1). The median age was 66 (range, 41-85) years. The median follow-up period was 66.5 (range, 5-139) months, with a median survival time of 132 months. The 1-, 3-, 5-, and 10-year disease-specific survival rates were 96%, 92%, 89%, and 89%, respectively; local recurrence-free survival rates were 99%, 99%, 95%, and 88%, respectively; lymph node metastasis rates were 3%, 5%, 9%, and 9%, respectively; and distant metastasis rates were 4%, 10%, 14%, and 17%, respectively. Univariate analysis revealed that the depth of invasion of the primary lesion was associated with local recurrence, with dermal involvement increasing the risk of local recurrence. Multivariate analysis revealed that the N and M stages were associated with disease prognosis. Radiation therapy is suitable for EMPD. Post-Mohs micrographic surgery radiation therapy provides excellent local control, and radical radiation therapy effectively controls tumors, including metastases.

#2

Diagnostic and therapeutic challenges in mammary and extra-mammary Paget disease: a retrospective case series.

Photodiagnosis and photodynamic therapy2026 Mar 12

Mammary and extramammary Paget disease (PD; MPD, EMPD) is a rare neoplastic disorder characterised by intraepithelial infiltration of malignant cells with glandular differentiation. Diagnosis of PD remains challenging, as its clinical presentation frequently mimics inflammatory diseases or other cutaneous neoplasms. It is estimated that approximately 10-15% of EMPD cases and up to 50% of MPD cases are invasive at the time of definitive diagnosis, largely due to diagnostic delays that may last several years. In this retrospective case series, we analysed non-pigmented EMPD (n = 8) and MPD (n = 5) to evaluate the diagnostic performance of selected non-invasive imaging techniques, including dermoscopy, photodynamic diagnosis, and reflectance confocal microscopy, highlighting their limitations and advantages during the primary investigation and disease surveillance over several years. Furthermore, we analysed diagnostic challenges in advanced, metastatic, and overlapping cases. The study also summarises the outcomes of multiple-line therapeutic approaches applied in high-risk EMPD patients and compares these results with data available in the current literature.

#3

Advances in the application of photodynamic diagnosis in Skin Tumors.

Photodiagnosis and photodynamic therapy2026 Mar 05

Photodynamic Diagnosis (PDD) is a non-invasive imaging technique. It relies on a photosensitizer that, when activated by a specific light source, causes metabolically active tissues like tumors to emit visible red fluorescence. PDD offers high sensitivity, high specificity, and real-time visualization. This article reviews advances in the use of PDD for common cutaneous tumors, including Keratinocyte Carcinoma and extramammary Paget disease (EMPD). In managing skin tumors, PDD can be used during preoperative, intraoperative, and postoperative stages. This helps optimize diagnosis and treatment. Preoperatively, PDD clearly delineates tumor margins and identifies subclinical lesions. It aids in planning surgical or photodynamic therapy-especially for multifocal or ill-defined lesions, such as Bowen's disease and actinic keratosis. Intraoperatively, PDD guides surgeons in determining excision boundaries in real-time. This increases the rate of negative margins (for example, up to 98.6% in cutaneous squamous cell carcinoma surgery) while reducing the number of surgical stages and tissue damage. Postoperatively, PDD can evaluate treatment response, monitor for residual disease, or detect early recurrence. This enables non-invasive, repeatable follow-up. Limitations of PDD include false positives due to inflammation, interference from nonspecific fluorescence, limited depth of fluorescence penetration, and variability in tumor tissue. Looking forward, new technologies such as nanotechnology, artificial intelligence, and multimodal imaging may broaden the use of fluorescence detection in dermatology.

#4

Clinicopathological Analysis of 40 Cases of Extramammary Paget Disease: A Retrospective Study.

Clinical, cosmetic and investigational dermatology2026

Extramammary Paget Disease (EMPD) is a rare intra-epithelial malignancy often misdiagnosed due to diverse clinical manifestations. This study retrospectively analyzed the clinicopathological features of 40 EMPD patients to provide references for clinical practice. Clinical data of 40 patients with pathologically confirmed EMPD were collected, including demographics, clinical features, histopathological and immunohistochemical findings, treatments, and follow-up outcomes. Of the 40 patients (27 males, 13 females; mean age 68.8 years), the most common onset location was the external genitalia (n = 33). Lesions primarily presented as erythema or red plaques (n = 38), with itching being the most common symptom (n = 26). Immunohistochemically, tumor cells were positive for CK7, CEA, and EMA, with positive rates of 70% for GCDFP-15 and 25% for CK20. Thirty-nine patients underwent surgical excision, and one received photodynamic therapy combined with radiotherapy. During follow-up after surgery, one patient with invasive features (tumor mass in the dermis) recurred but achieved remission after reoperation; the other 38 patients remained disease-free. Invasive EMPD was associated with a higher risk of recurrence. EMPD's varied presentations pose diagnostic challenges. Key diagnostic differentials include eczema, psoriasis, and melanoma, particularly for rare pigmented or depigmented variants. For clinicians, a high index of suspicion and prompt biopsy are crucial for early diagnosis. For pathologists, a comprehensive immunohistochemical panel is essential, while CK20's utility in distinguishing primary from secondary disease is limited and warrants further malignancy screening. Surgical excision remains the primary treatment, with alternative therapies effective for inoperable cases. Early diagnosis, appropriate treatment, and long-term follow-up are crucial for optimal prognosis.

#5

Management of Extramammary Paget Disease of the Male Genital Region: A Narrative Review and Two Case Reports.

Journal of clinical medicine2026 Feb 09

Background/Objectives: Extramammary Paget disease (EMPD) is a rare, slow-growing intraepithelial malignancy arising in apocrine gland-bearing skin, most commonly in the anogenital region. Although often confined to the epidermis, EMPD may be associated with synchronous or underlying malignancies and can progress to invasive disease, making early recognition and compre- hensive staging crucial. Methods: We review current knowledge on the epidemiology, molecular pathogenesis, diagnostic work-up and treatment of EMPD with a particular focus on male genital involvement, and illustrate key clinical issues with two cases of penoscrotal EMPD treated in our center. Clinically, EMPD typically presents as chronic erythematous, pruritic plaques that are frequently misdiagnosed as benign dermatoses, leading to diagnostic delays. Results: Histopathology with immunohistochemistry remains the diagnostic gold standard and guides the search for associated internal malignancies. Wide local excision and Mohs micrographic surgery are the mainstays of treatment, but recurrence is common owing to subclinical extension. Non-surgical modalities-including photodynamic therapy, topical imiquimod, radiotherapy and, in advanced disease, systemic chemotherapy, HER2 targeted agents and immune checkpoint inhibitors-provide additional options in selected patients. Conclusions: A multidisciplinary, biomarker driven approach is essential to individualize management and improve long-term outcomes in this challenging disease.

Publicações recentes

Genomic Alterations in Perianal and Scrotal Extramammary Paget Disease: A Retrospective Case Series.

Dermatol Surg2026 Apr 10

The Spaghetti Technique of Modified Mohs Surgery in Extramammary Paget Disease.

Dermatol Surg2026 Apr 8

Immunohistochemical evaluation of gastric-type markers in primary extramammary Paget disease: Differential MUC5AC expression between in situ and invasive lesions.

Exp Ther Med2026 May

Common Vulvar Neoplasms-Benign and Malignant.

Clin Obstet Gynecol2026 Mar 30

Efficacy of Radiation Therapy in 106 Patients with Extramammary Paget Disease: A Retrospective Study.

Adv Radiat Oncol2026 Apr

Ver todas no PubMed

📚 EuropePMC325 artigos no totalmostrando 198

Advances in radiation oncology

Efficacy of Radiation Therapy in 106 Patients with Extramammary Paget Disease: A Retrospective Study.

Photodiagnosis and photodynamic therapy

Diagnostic and therapeutic challenges in mammary and extra-mammary Paget disease: a retrospective case series.

Pain and Scrotal Involvement are Associated with Misdiagnosis in Extramammary Paget Disease: A Retrospective Cohort Study.

Photodiagnosis and photodynamic therapy

Advances in the application of photodynamic diagnosis in Skin Tumors.

Clinical, cosmetic and investigational dermatology

Clinicopathological Analysis of 40 Cases of Extramammary Paget Disease: A Retrospective Study.

Journal of clinical medicine

Management of Extramammary Paget Disease of the Male Genital Region: A Narrative Review and Two Case Reports.

Applied immunohistochemistry & molecular morphology : AIMM

TRPS1 Expression Across the Spectrum of Paget Disease and Morphologic Mimics.

Therapeutic Algorithm for Extramammary Paget Disease: Experience in a Dermatology Referral Center in Western Mexico.

Journal of pathology and translational medicine

The evolving role of TRPS1 in dermatopathology: insights from the past 4 years.

Perianal Paget's Disease From Underlying Anal Adenocarcinoma: A Case Study.

Advances in anatomic pathology

Intraepithelial Penile Lesions.

Extramammary Paget Disease Secondary to Axillary Apocrine Carcinoma: Highlighting the Diagnostic Utility of a Limited Immunohistochemical Panel in a Resource-Limited Setting.

Prostein (p501s) is expressed in primary extramammary Paget disease.

Histopathology

Real-World Efficacy of Chemotherapy in Patients With Advanced Unresectable Extramammary Paget Disease: A Retrospective Multicenter Study of 138 Japanese Patients.

Diagnostic Algorithm for Secondary Extramammary Paget Disease from Institutional Cases and Literature Review.

Cancers

Clinicopathologic features and prognostic factors of surgically treated extramammary Paget disease of the vulva: A retrospective cohort analysis.

International journal of women's dermatology

Extramammary Paget's disease: when is enough, enough?

Critical reviews in oncology/hematology

HER2 in gynecological malignancies: Bridging the gap between standardized pathological assessment and precision therapy.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Risk of Associated Visceral Malignancies in Patients With Extra-anogenital Extramammary Paget Disease.

Case reports in dermatology

Axillary Breast Cancer Masquerading as Extramammary Paget Disease after Bilateral Total Mastectomy: A Case Report.

Indian journal of dermatology

Successful Treatment of Primary Extramammary Paget Disease with a Combined Ablative Carbon Dioxide Laser and Topical Imiquimod.

Serum Nectin-4 as a Potential Prognostic Biomarker for Extramammary Paget Disease.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc

Perianal Intestinal-Type Paget Disease With and Without Invasion, Unassociated With Internal Malignancy: A Distinct Form of Primary Perianal Adenocarcinoma.

Hinyokika kiyo. Acta urologica Japonica

[Vaginal and Vulval Secondary Extramammary Paget's Disease Associated with Urothelial Carcinoma in Situ : A Case Report].

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Factors Affecting Time to Surgery in Patients With Extramammary Paget Disease in the United States.

PRAME Expression in Mammary and Extramammary Paget Disease.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

TRPS1 Reliably Stains Benign and Malignant Lesions Arising Within Vulvar Anogenital Mammary-like Glands.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Dermatologic Oncology: The Past 50 Years.

Clinical, cosmetic and investigational dermatology

Pigmented Extramammary Paget's Disease of the Axilla: Two Case Reports and a Literature Review.

Spiny Keratoderma in Association With Extramammary Paget Disease.

Mayo Clinic proceedings

Japanese Dermatological Association Guidelines: Clinical Questions of Guidelines for Extramammary Paget Disease 2025.

A Case of Umbilical Invasive Extramammary Paget Disease With a High Tumor Mutational Burden Successfully Treated With Pembrolizumab.

Spontaneously Regressing Penile Extramammary Paget Disease without Recurrence of Primary Urothelial Carcinoma: A Case Report.

Case reports in oncology

Critical reviews in oncology/hematology

The role of HER2 pathway in vulvar paget's disease.

A combined inferior epigastric artery perforator propeller flap with scrotal flap for the reconstruction of a massive penoscrotal defect:A case report.

Urology case reports

Gynecologic oncology reports

Trastuzumab monotherapy as maintenance treatment for metastatic HER2+ vulvar Paget disease: systematic review and case report.

Plastic and reconstructive surgery. Global open

Extramammary Paget Disease in the Peristomal Skin of an Ileal Conduit Reconstructed With a Pedicled Anterolateral Thigh Flap.

European journal of cancer (Oxford, England : 1990)

Mapping the potential for anti-PD-1 therapy in advanced rare skin carcinomas.

Italian journal of dermatology and venereology

Evolution of perianal extramammary Paget disease from an erythematous patch to an achromic patch.

Line-field confocal optical coherence tomography-controlled cryotherapy for extramammary Paget disease: a case report.

Secondary extramammary Paget disease with presumed origin in the external ear's ceruminous gland.

Transurethral resection and oral mucosal grafting for urethral-involved extramammary Paget disease: A function-preserving approach.

Diagnostics (Basel, Switzerland)

Transperineal Vulvar Ultrasound: A Review of Normal and Abnormal Findings with a Proposed Standardized Methodology.

Clinical characteristics and prognostic factors associated with in situ extramammary Paget disease in the United States.

Photodynamic Therapy: Clinical Applications in Dermatology.

Pulsed dye laser-activated photodynamic therapy for extramammary Paget disease.

Archives of dermatological research

Cause-specific survival of mohs micrographic surgery versus wide local excision in extramammary Paget disease: a retrospective cohort study.

A multicenter study on TROP2 as a potential targeted therapy for extramammary Paget disease in Japan.

Scientific reports

Extramammary Paget disease.

International journal of surgical pathology

Perianal Paget Disease With an Enteric Phenotype and Associated In-Situ/Dysplastic Glandular Component: Report of a Potentially Novel Entity and Review of the Literature.

The diagnostic challenges of differentiating metastatic extramammary Paget disease and prostatic adenocarcinoma: A case report and review of the literature.

Urology case reports

Tislelizumab plus chemotherapy in metastatic extramammary Paget disease after surgery: a case report.

Plastic and reconstructive surgery. Global open

Repair of Scrotal Wounds after Extensive Excision of Extramammary Paget Disease with Thick Split-thickness Skin Graft.

Dermatology (Basel, Switzerland)

A Territory-Wide Follow-Up of Primary and Secondary Extramammary Paget Disease of 2 Decades: Effects of Local Disease on Survival.

Beyond the Surface: Dermoscopic, Clinical, and Histopathological Insights Into Secondary Extramammary Paget Disease of the Glans Linked to Urothelial Carcinoma.

Extramammary Paget's disease treated with of anti-programmed cell death protein 1 therapy after docetaxel therapy failure.

Tertiary lymphoid structures associated with improved prognosis and reduced invasion in advanced extramammary Paget disease.

Gynecologic oncology reports

Invasive acantholytic anaplastic extramammary Paget disease: A previously unreported neoplasm in the vulva and review of the literature.

Genomics predicting prognosis in metastatic extramammary Paget disease.

Impact of lesion location and pattern on the prognosis of genital extramammary Paget disease: a retrospective study.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Multiple Moat Modification of Mohs Micrographic Surgery for the Treatment of Anogenital Extramammary Paget Disease: Challenges and Considerations.

Simultaneous Occurrence of Two Ectopic Extramammary Paget Disease Lesions: A Case Report.

Axillary extramammary Paget disease in a patient with a history of Birt-Hogg-Dubé syndrome.

JAAD international

Virchows Archiv : an international journal of pathology

Utility of special AT-rich sequence-binding protein 2 (SATB2) immunohistochemistry as a marker for secondary perianal paget disease.

Association of genetic alterations with prognosis in extramammary Paget disease: insights into the involvement of somatic CDKN2A variants in patients with a poor prognosis.

Diagnostics (Basel, Switzerland)

The Role of Line-Field Confocal Optical Coherence Tomography in Detecting Extramammary Paget Disease Recurrences: A Pilot Diagnostic Study.

Case report: Pyrotinib in the treatment of advanced scrotal EMPD combined with sweat gland carcinoma.

British journal of cancer

Establishment of a trastuzumab-resistant extramammary Paget disease model: loss of PTEN as a potential mechanism.

CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne

Multiple-site primary extramammary Paget disease in a 77-year-old man.

Scrotal Cancer Incidence Rates and Trends-United States, 1999-2020.

Urology

Pedunculated Neoplasm of the Vulva.

International journal of dermatology

Sex disparities in surgery for extramammary Paget disease: a SEER population-based study.

Unusual case of extramammary Paget disease of the oral mucosa: A case report and literature review.

Dermatology (Basel, Switzerland)

Preoperative Mapping Biopsies with Local Excision in the Treatment of Extramammary Paget Disease: A Retrospective Cohort Study, Systematic Review, and Individual Patient Data Analysis.

Assessment of HER2 status in extramammary Paget disease and its implication for disitamab vedotin, a novel humanized anti-HER2 antibody-drug conjugate therapy.

Frontiers of medicine

Extramammary Paget disease. Part I. epidemiology, pathogenesis, clinical features, and diagnosis.

Virchows Archiv : an international journal of pathology

Esophageal squamous cell carcinoma with pagetoid spread: a clinicopathologic study.

Extramammary Paget Disease of Oral Mucosa: Case Report with Literature Review.

Head and neck pathology

Loss of p16 Immunoexpression and Deletions of CDKN2A in the Progression of Extramammary Paget Disease: An Immunohistochemical and Genetic Study of 24 Invasive/Metastatic Cases.

A rare case of metastatic extramammary Paget disease developing transfusion-related acute lung injury during chemotherapy.

Extramammary Paget disease. Part II. Evidence-based approach to management.

Case report: A case of Paget disease outside the axillary breast.

Medicine

Treatment of extramammary Paget disease with imiquimod in a real-life setting: a multicentre retrospective analysis in Spain.

American journal of surgery

Paget's disease of the breast: Insights from imaging to guide surgical management.

NECTIN4-targeted antibody-drug conjugate is a potential therapeutic option for extramammary Paget disease.

Identification of a rare MET variant in three siblings with extramammary Paget disease.

Anatomic Subtype Differences in Extramammary Paget Disease: A Meta-Analysis.

JAMA dermatology

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland

Perianal extramammary Paget disease: our experience of two cases - a video vignette.

Journal of pathology and translational medicine

TRPS1 expression in non-melanocytic cutaneous neoplasms: an immunohistochemical analysis of 200 cases.

FOXM1: a new therapeutic target of extramammary Paget disease.

Scientific reports

Incidence and survival rates of primary cutaneous malignancies in Korea, 1999-2019: A nationwide population-based study.

Eribulin for patients with metastatic extramammary Paget disease: Study protocol for a single-arm phase II trial.

Journal of cutaneous medicine and surgery

A Review of the Dermatologic Clinical Applications of Topical Photodynamic Therapy.

The elusive extremities: a case of extramammary Paget disease.

BMJ case reports

A rare case of extramammary Paget disease in a young HIV-positive man.

Plastic and reconstructive surgery. Global open

Immediate Lymphatic Reconstruction Using a Handheld Fluorescence Imaging Device.

Mutational landscape of advanced extramammary Paget disease with comprehensive genomic profiling tests: A cohort study in a Japanese real-world setting.

Topical Imiquimod in Primary Cutaneous Extramammary Paget's Disease: A Systematic Review.

Cancers

Pathologically Confirmed Subcutaneous Fat and Lymphovascular Invasion of a Hypopigmented Area in Extramammary Paget Disease.

Annals of dermatology

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

Ultrasonography for the Diagnosis and Follow-Up of Extramammary Paget Disease (EMPD): A Review.

Indian journal of dermatology, venereology and leprology

Impact of combining photodynamic diagnosis with reflectance confocal microscopy, on tumor margin detection and surgical outcomes in patients with extramammary Paget disease.

A case of male Paget's disease of the breast.

Asian journal of surgery

TRPS1 expression in primary and secondary extramammary Paget diseases: An immunohistochemical analysis of 93 cases.

Human pathology

Dermatology practical & conceptual

Photodynamic Therapy for Primary Cutaneous Extramammary Paget Disease.

Identification of Predictive Factors for Post-operative Recurrence and Clinical Outcomes of Primary Vulvar Extramammary Paget Disease.

In vivo (Athens, Greece)

The Australasian journal of dermatology

Hypopigmentation as a diagnostic clue in primary extramammary Paget disease: Case report and short literature review.

The Gulf journal of oncology

Scrotal Wall Metastasis from Adenocarcinoma of Unknown Origin, with Concurrent Extramammary Paget's Disease - a Case Report.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Commentary on "Reconstruction of a Large Extramammary Paget Disease Pelvic Defect".

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Reconstruction of a Large Extramammary Paget Disease Pelvic Defect.

Transcriptional repressor GATA binding 1 (TRPS1) immunoexpression in normal skin tissues and various cutaneous tumors.

Elevated Risk of Visceral Malignant Neoplasms in Extramammary Paget Disease.

JAMA dermatology

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Perianal Malignancies: A Review for the Dermatologic Surgeon.

Pathology, research and practice

Clinicopathological significance of androgen receptor expression in extramammary Paget disease: An analysis of 92 patients.

Journal of drugs in dermatology : JDD

EXTRA, EXTRA, Treatment Approaches for EXTRAmammary Paget Disease.

Annals of plastic surgery

A Simplified Algorithmic Approach to Vulvar Reconstruction According to Various Types of Vulvar Defects.

Treatment of high tumor mutation burden metastatic extramammary Paget disease with an anti-PD-1 antibody.

Extramammary Paget Disease: a Therapeutic Challenge, for a Rare Entity.

Current oncology reports

Journal of surgical case reports

Perianal extramammary Paget's disease with adenocarcinoma of perianal skin area, a case report.

Claudin-4 Expression in the Distinction of Mammary and Extramammary Paget Disease From Morphologic Mimics: Diagnostic Utility and Pitfalls.

Archives of dermatological research

The role of sentinel lymph node biopsy in extramammary paget disease: a systematic review.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Prognostic Analysis of Patients With Extramammary Paget Disease Treated With Conservative Excision.

The utility of p63, CK7, and CAM5.2 staining in differentiating pagetoid intraepidermal carcinomas.

Efficacy of chemotherapies for unresectable extramammary Paget disease: a single-centre retrospective study.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Patient's Experience With Imiquimod for Extramammary Paget Disease.

Annals of the Royal College of Surgeons of England

Recurrent primary scrotal extramammary Paget disease: a case report and literature review.

Extramammary Paget disease of the buccal mucosa in an elderly patient.

Gerodontology

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Treatment Outcomes of Adjunct and Stand-alone Photodynamic Therapy in Patients With Extramammary Paget Disease: A Literature Review.

National screening practices in vulval extramammary Paget disease: a multicentre UK audit.

TRPS1 expression is sensitive and specific for primary extramammary Paget disease.

Histopathology

Eroded pigmented anogenital plaque in an elderly woman.

International journal of dermatology

Extramammary Paget disease imaged by LC-OCT and treated with radiotherapy.

Pagetoid Spread in Basal Cell Carcinoma: Potential for Misdiagnosis.

A retrospective case series of Mohs micrographic surgery and interdisciplinary management of female genital skin cancers: Local recurrence rates and patient-reported outcomes.

Annals of translational medicine

Health-related quality of life and associated factors among non-melanoma skin cancer patients: a cross-sectional study.

'Get Data Out' Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England.

Immunohistochemical expression of TRPS1 in mammary Paget disease, extramammary Paget disease, and their close histopathologic mimics.

Clinical features of pagetoid spread: Analysis of perianal lesions associated with anal canal adenocarcinoma and perianal primary extramammary Paget disease.

Research letter: A new fluorescent three-dimensional and deep-imaging technique for histological identification of individual tumor cells in extramammary Paget's disease.

A Rare Collison of Vulvar Melanoma and Extramammary Paget Disease: Case Report and Review of the Literature.

Pathology, research and practice

Extramammary paget disease of the penoscrotal region.

Lichenoid lesions around the anus: An unusual site of Hailey-Hailey disease.

Clinical case reports

International journal of surgical pathology

Pagetoid Squamous Intraepithelial Neoplasia of the Vulva as a Mimicker of Vulvar Extramammary Paget Disease: Two Cases with Basal Layer Sparing.

Actas dermo-sifiliograficas

Cutaneous Apocrine Adenocarcinoma of the Groin With Extramammary Paget Disease: Response to Dual HER2 Blockade With Trastuzumab and Pertuzumab.

Sentinel lymph node biopsy in extramammary Paget disease: A 13-year institutional experience.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Local Recurrence Rates of Extramammary Paget Disease Are Lower After Mohs Micrographic Surgery Compared With Wide Local Excision: A Systematic Review and Meta-Analysis.

Reconstruction of the male external genitalia in diverse disease processes: Our reconstructive algorithm, techniques, and experience.

Current urology

Cell origin and genome profile difference of penoscrotum invasive extramammary Paget disease compared with its in situ counterpart.

Pagetoid Dyskeratosis of the Hand With Parallel Ridge Pattern on Dermoscopy and Expression of Bcl-10 by Immunohistochemistry.

Case Report: Prolonged clinical benefit with sequential trastuzumab-containing treatments in a patient with advanced extramammary Paget disease of the groin.

Perianal Paget disease associated with non-invasive colorectal adenoma.

Compound Clear Cell Sarcoma: A Case Report With Ulceration and Pagetoid Scatter.

Neutrophil-to-lymphocyte ratio is a potential prognostic biomarker for extramammary Paget disease: A retrospective study.

Journal of lower genital tract disease

The European Society of Gynaecological Oncology (ESGO), the International Society for the Study of Vulvovaginal Disease (ISSVD), the European College for the Study of Vulval Disease (ECSVD) and the European Federation for Colposcopy (EFC) Consensus Statements on Pre-invasive Vulvar Lesions.

Treatment of Metastatic Primary Extramammary Paget Disease With Combination Anlotinib and Tislelizumab: A Case Report and Review of the Literature.

Frontiers in medicine

Extramammary Paget disease of the axilla and scrotum in a Caucasian man.

Lasers in surgery and medicine

Fluorescence kinetics study of twice laser irradiation based HpD-PDT for nonmelanoma skin cancer.

Invasive and non-invasive extramammary perianal Paget's disease: Understanding of carcinogenesis determines individualized treatment.

Cirugia espanola

Assessment of Extramammary Paget Disease by Two-Photon Microscopy.

Frontiers in medicine

Penile extramammary Paget disease associated with urothelial carcinoma in situ: Case report and literature review.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie

CK 8∕18: the key to differentiating intracutaneous lesions with pagetoid features.

International journal of urology : official journal of the Japanese Urological Association

Boron neutron capture therapy for urological cancers.

Depigmentation of the vulvar area: Is it an alarming sign?

Clinical case reports

Archives of gynecology and obstetrics

"Clock mapping" prior to excisional surgery in vulvar Paget's disease: tailoring the surgical plan.

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.

JAMA oncology

International journal of surgery case reports

Laparoscopic pelvic surgery after reconstructive surgery with vertical rectus abdominis muscle flap: A case report.

Unusual lesion on the vulva of a postmenopausal woman.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Reflectance Confocal Microscopy-Targeted Extramammary Paget Disease Before Mohs Micrographic Surgery.

Extramammary Paget's Disease in the Genital Area of a Male: A Case Report and Review of the Literature.

American journal of obstetrics and gynecology

Treatment-refractory extramammary Paget disease responsive to radiotherapy.

Poorly Differentiated Scrotal Carcinoma With Apocrine Immunophenotype.

The American journal of case reports

Vulvar Extramammary Paget Disease Detected by Cytology for Cervical Cancer Screening: A Case Report and Literature Review.

International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists

Unusual Manifestations of Vulval Paget Disease.

Journal of gastroenterology and hepatology

Gastrointestinal: Extramammary Paget disease of the esophagus.

Investigational new drugs

Successful treatment of a case of hormone receptor-positive metastatic extramammary Paget disease with tamoxifen.

Axillary Paget disease with a visible satellite: a case report and literature review.

Diagnostic pathology

International journal of dermatology

Parallel ridge pattern in palmar pagetoid dyskeratosis: a dermoscopic pitfall.

Perianal Paget Disease: Different Entities With the Same Name.

Journal of surgical case reports

Extramammary Paget disease: five perianal case report and treatment options.

Intradermal Band-like Lipomatous Metaplasia Can Be Associated With the Regression of Overlying Skin Neoplasms: A Clinicopathologic Study of 20 Cases.

Vulvar pagetoid urothelial intraepithelial neoplasia: a case report.

Acta chirurgica Belgica

Anais brasileiros de dermatologia

Pagetoid dyskeratosis in dermatopathology.

Anogenital syringocystadenocarcinoma papilliferum in situ or anaplastic extramammary Paget disease? A unifying concept and review of the literature.

In vivo identification of tumor cells of the basal layer of the epidermis in an early lesion of extramammary Paget disease: A reflectance confocal microscopic analysis.

Dermatology online journal

Ectopic extramammary Paget disease in thoracic location.

Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine

High-Frequency Ultrasound for Evaluation of the Pathological Invasion Level of Extramammary Paget Disease.

World journal of surgical oncology

Survival analysis of extramammary Paget's disease (EMPD) in a tertiary hospital in Taiwan.

Aberrant Melan-A Expression in Extramammary Paget Disease.

Treatment of Metastatic Extramammary Paget Disease with Combination Ipilimumab and Nivolumab: A Case Report.

Case reports in oncology

Indian journal of dermatology, venereology and leprology

Utility of photodynamic diagnosis plus reflectance confocal microscopy in detecting the margins of extramammary Paget disease.

Dermatology practical & conceptual

Usefulness of Topical Imiquimod 3.75% in Cytokeratin 7 Positive Extramammary Paget Disease of the Vulva: Towards Personalized Therapy.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Treatment of Extramammary Paget Disease and the Role of Reflectance Confocal Microscopy: A Prospective Study.

Clinical nuclear medicine

68Ga-FAPI and 18F-FDG PET/CT in Perineum Extramammary Paget Disease.

Longitudinal multicentre retrospective cohort study of treatment outcomes in extramammary Paget disease.

Obstetrical & gynecological survey

Vulvar Intraepithelial Neoplasia: A Review of the Disease and Current Management.

Neutrophil/lymphocyte ratio as a predictor of lymph node metastasis in extramammary Paget disease: A retrospective study.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Reflectance Confocal Microscopy as a Promising Adjunctive Tool for Treatment Planning in Extramammary Paget's Disease.

Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]

Hypopigmentation in Extramammary Paget Disease Is an Important Prognostic Factor for High Recurrence Rate and Poor Surgical Outcome.

Ver todos os 325 no EuropePMC

[Extra Mammary Paget disease].

Annales de pathologie

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Associações

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Doença com base genética

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Conselhos e sociedades

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