Raras
Buscar doenças, sintomas, genes...
Doença de Whipple
ORPHA:3452CID-10 · M14.8*CID-11 · DA96.0YDOENÇA RARA

É uma infecção que afeta várias partes do corpo, causada por uma bactéria chamada Tropheryma whipplei. Ela atinge o intestino delgado, dificultando a absorção de nutrientes. Além disso, a infecção pode afetar outras partes, como as articulações, o sistema nervoso (cérebro e medula espinhal) e o coração e os vasos sanguíneos.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

É uma infecção que afeta várias partes do corpo, causada por uma bactéria chamada Tropheryma whipplei. Ela atinge o intestino delgado, dificultando a absorção de nutrientes. Além disso, a infecção pode afetar outras partes, como as articulações, o sistema nervoso (cérebro e medula espinhal) e o coração e os vasos sanguíneos.

Publicações científicas
311 artigos
Último publicado: 2026

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
No data available
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: M14.8*
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
6 sintomas
🫃
Digestivo
6 sintomas
📏
Crescimento
4 sintomas
💪
Músculos
3 sintomas
❤️
Coração
3 sintomas
🩸
Sangue
2 sintomas

+ 17 sintomas em outras categorias

Características mais comuns

90%prev.
Má absorção
Muito frequente (99-80%)
90%prev.
Depressão
Muito frequente (99-80%)
90%prev.
Dor abdominal
Muito frequente (99-80%)
90%prev.
Fadiga
Muito frequente (99-80%)
90%prev.
Regressão do desenvolvimento
Muito frequente (99-80%)
90%prev.
Anorexia
Muito frequente (99-80%)
47sintomas
Muito frequente (13)
Frequente (7)
Ocasional (27)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 47 características clínicas mais associadas, ordenadas por frequência.

Má absorçãoMalabsorption
Muito frequente (99-80%)90%
DepressãoDepression
Muito frequente (99-80%)90%
Dor abdominalAbdominal pain
Muito frequente (99-80%)90%
FadigaFatigue
Muito frequente (99-80%)90%
Regressão do desenvolvimentoDevelopmental regression
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico311PubMed
Últimos 10 anos200publicações
Pico202139 papers
Linha do tempo
2026Hoje · 2026🧪 2003Primeiro ensaio clínico📈 2021Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

1 gene identificado com associação a esta condição. Padrão de herança: Not applicable.

IRF4Interferon regulatory factor 4Major susceptibility factor inAltamente restrito
FUNÇÃO

Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. Involved in CD8(+) dendritic cell differentiation by forming a complex with the BATF-JUNB heterodimer in immune cells, leading to recognition of AICE sequence (5'-TGAnTCA/GAAA-3'), an immune-specific regulatory el

LOCALIZAÇÃO

NucleusCytoplasm

VIAS BIOLÓGICAS (4)
Interferon gamma signalingInterferon alpha/beta signalingNuclear events stimulated by ALK signaling in cancerInterleukin-4 and Interleukin-13 signaling
MECANISMO DE DOENÇA

Multiple myeloma

A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.

EXPRESSÃO TECIDUAL(Tecido-específico)
Linfócitos
385.0 TPM
Cervix Ectocervix
33.4 TPM
Baço
26.6 TPM
Cervix Endocervix
21.3 TPM
Intestino delgado
13.1 TPM
OUTRAS DOENÇAS (2)
immunodeficiency 131Whipple disease
HGNC:6119UniProt:Q15306

Variantes genéticas (ClinVar)

70 variantes patogênicas registradas no ClinVar.

🧬 IRF4: NM_002460.4(IRF4):c.298G>A (p.Ala100Thr) ()
🧬 IRF4: NM_002460.4(IRF4):c.1213-261C>A ()
🧬 IRF4: GRCh37/hg19 6p25.3-25.1(chr6:154749-5886174)x1 ()
🧬 IRF4: GRCh37/hg19 6p25.3(chr6:156975-2132685)x1 ()
🧬 IRF4: NM_002460.4(IRF4):c.283A>G (p.Thr95Ala) ()
Ver todas no ClinVar

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
·Pré-clínico2
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 2 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Doença de Whipple

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

2 ensaios clínicos encontrados.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
123 papers (10 anos)
#1

Clinical experience with metagenomic next-generation sequencing (mNGS) for the detection of Tropheryma whipplei in respiratory specimens: A multicenter retrospective observational study.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases2026 Apr

Tropheryma whipplei (T. whipplei) is the causative bacterium of Whipple's disease (WD), a chronic and systemic infectious condition that predominantly affects the gastrointestinal tract. Sporadic cases of T. whipplei pneumonia have been documented recently. This multicenter retrospective observational study was conducted on patients with T. whipplei positive respiratory specimens admitted to Peking University People's Hospital and China-Japan Friendship Hospital, from Apr 2021 to Jul 2024. Metagenomic next-Generation sequencing (mNGS) was performed using the patient's bronchoalveolar lavage fluid (BALF), and the quantitative polymerase chain reaction (qPCR) of T. whipplei was also adopted. The clinical data of patients were systematically evaluated. Among 91 patients (aged 25-82, mean 57; 48% male), common symptoms included cough (60%), expectoration (48%), dyspnea (42%), and fever (30%). Notably, 22% were asymptomatic. Besides, 20 patients (22%) had a pre-existing condition of interstitial lung disease. Among all 91 patients, 14 were diagnosed with pneumonia, while the remaining 77 had bacterial colonization. Pneumonia cases showed higher T. whipplei mNGS reads than colonization (P = 0.0298). Samples testing positive for T. whipplei by qPCR exhibited significantly higher mNGS sequence reads compared to qPCR-negative samples (P < 0.0001). All pneumonia patients received antibiotics therapy tailored to their condition. One died from respiratory failure, while the remaining 13 recovered. The application of mNGS on respiratory specimens stands as an exceptional diagnostic modality, proficient in identifying rare microbial infections, exemplified by those induced by T. whipplei. Future research should launch prospective trials to optimize regimens, assess outcomes, and track long-term survival precisely.

#2

Deciphering whipple's disease complexity.

Clinical and experimental medicine2026 Feb 06

Whipple's disease is a sporadic infectious condition, with an incidence rate of approximately 1 per million individuals. The causative agent is the gram-positive bacterium Tropheryma whipplei. The disease manifests with a wide range of clinical symptoms, including non-specific presentations such as diarrhea, arthralgia, and fever, as well as the more pathognomonic lipodystrophy. This diversity in presentation poses a significant diagnostic challenge even for experienced clinicians. Our review aims to provide an updated overview encompassing the latest insights into Whipple's disease, focusing on epidemiology, pathophysiology, genetic predisposition, clinical manifestations, diagnosis, immune reconstitution inflammatory syndrome, and treatment. Herein, we have additionally explored many of the confounding factors in the diagnosis and management of Whipple's disease, including the variable presentations among patients colonized by Trophyrema whipplei as well as the limitations of current treatment options, and underscore the need for further research and guidelines related to this complex disease process.

#3

Whipple's Disease: Panniculitis Among Other Dermatoses. A Case Report and Literature Review.

Journal of cutaneous pathology2026 Feb 03

Whipple's disease (WD) is a rare infectious disease caused by Tropheryma whipplei, which primarily affects the gastrointestinal tract but may also involve the joints, central nervous system, and skin. Although cutaneous manifestations are often overlooked, they can provide valuable diagnostic clues. We report the case of a 54-year-old male with long-standing seronegative migratory polyarthritis refractory to conventional treatment, who subsequently developed multiple subcutaneous inflammatory nodules and systemic symptoms. Histopathological examination of these lesions revealed a non-vasculitic, septal-predominant panniculitis with foamy macrophages containing periodic acid-Schiff (PAS)-positive diastase-resistant intracytoplasmic inclusions, raising a strong suspicion of Whipple's disease. Subsequent duodenal biopsies confirmed the diagnosis by electron microscopy and polymerase chain reaction (PCR) for T. whipplei. Panniculitis in WD represents a highly specific but rarely reported finding, characterized by thickened subcutaneous septa with partial lobular involvement, foamy macrophage infiltration, and absence of vasculitis. A literature review identified 15 cases of histologically confirmed WD-associated panniculitis, suggesting that this manifestation may be under-recognized in clinical practice. This study underscores the importance of cutaneous pathology in WD and expands current knowledge on its dermatological manifestations by providing clinicopathologic, ultrastructural, and literature-based data.

#4

Tropheryma whipplei Infection Presenting Initially with Chest Pain.

Clinical laboratory2026 Jan 01

Tropheryma whipplei is a rare pathogenic bacterium, a Gram-positive actinomycete widely distributed in the natural environment. It mainly infects individuals with immunodeficiency, but is rarely observed in individuals with normal immune function. Most patients present with non-specific symptoms, and since it is not feasible to culture the bacteria using conventional methods, diagnosing this infection is very difficult. In this case, next-generation sequencing (NGS) detection via bronchoscopy confirmed the final diagnosis of Tropheryma whipplei infection. Bronchoscopy and next-generation sequencing were used. Through bronchoscopy, NGS of bronchoalveolar lavage fluid indicated the presence of Tropheryma whipplei. Therefore, anti-infective treatment was administered. For cases of long-standing chest pain of unknown origin with abnormal findings on chest imaging, it is crucial to stabilize the patient's condition while identifying the underlying cause. Prompt implementation of relevant diagnostic procedures, such as bronchoscopy, is essential for establishing a diagnosis.

#5

Atypical Migrating Nummular Retinal Lesions in an Immunosuppressed Patient With Whipple Disease.

ACG case reports journal2026 Jan

Whipple disease is a rare systemic infection of Tropheryma whipplei with nonspecific clinical features. Ocular involvement is uncommon but has been reported in both anterior and posterior segments of the eye. We present the case of a 70-year-old man with a history of cutaneous T-cell lymphoma, who developed unilateral ocular inflammation with hypopyon, vitritis, and migrating nummular retinal lesions. Despite intravitreal antimicrobial therapy, inflammation persisted. Four months later, he developed systemic symptoms and findings on duodenal biopsy consistent with Whipple disease. This case highlights an atypical ocular presentation suspected to be associated with Whipple disease and the diagnostic challenges in immunocompromised patients lacking classical gastrointestinal symptoms.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC223 artigos no totalmostrando 196

2026

Clinical experience with metagenomic next-generation sequencing (mNGS) for the detection of Tropheryma whipplei in respiratory specimens: A multicenter retrospective observational study.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2026

Deciphering whipple's disease complexity.

Clinical and experimental medicine
2026

Whipple's Disease: Panniculitis Among Other Dermatoses. A Case Report and Literature Review.

Journal of cutaneous pathology
2026

Tropheryma whipplei Infection Presenting Initially with Chest Pain.

Clinical laboratory
2026

Atypical Migrating Nummular Retinal Lesions in an Immunosuppressed Patient With Whipple Disease.

ACG case reports journal
2026

When it's not RA: unmasking Whipple's disease in seronegative, difficult-to-treat rheumatoid arthritis.

Clinical rheumatology
2025

Subacute cutaneous lupus erythematosus in a patient with Whipple's disease.

BMJ case reports
2025

Interplay of multiple neurological conditions - the first case of neurological Whipple's disease in Syria: a case report.

Annals of medicine and surgery (2012)
2025

A case of pulmonary nodular lesion caused by Tropheryma whipplei infection: a case report and literature review.

BMC pulmonary medicine
2026

Mitral Valve Endocarditis Due to Whipple Disease: A Rare Cause of Subacute Endocarditis.

JACC. Case reports
2026

Whipple's disease presenting with bone marrow findings mimicking prefibrotic myelofibrosis: A diagnostic pitfall.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2025

Chronic Bilateral Uveitis as the Presenting Manifestation of Ocular Whipple's Disease Confirmed by Vitreous PCR.

Ocular immunology and inflammation
2025

Movement Disorders and Oculomotor Abnormalities in Whipple's Disease: An Updated Systematic Review.

Tremor and other hyperkinetic movements (New York, N.Y.)
2026

Severe Precapillary Pulmonary Hypertension Due to Whipple Disease.

JACC. Case reports
2026

The high prevalence of Whipple's disease in patients with inflammatory rheumatic diseases.

Clinical and experimental rheumatology
2025

Analysis of clinical and imaging features and prognosis of patients positive for Tropheryma whipplei detected by nanopore sequencing of bronchoalveolar lavage fluid.

Frontiers in cellular and infection microbiology
2025

Tracking the Path of Migratory Pain: Unveiling Whipple Disease.

Cureus
2025

Lymphoma combined with Tropheryma whipplei infection: A case report and literature review.

Medicine
2025

Exploring murE protein inhibitors of Tropheryma whipplei through pharmacoinformatic approaches incorporating solubility-enhancing formulation insights.

Frontiers in pharmacology
2026

[From stroke via swollen joints to M. Whipple: case report from neurological rehabilitation and review of literature].

Fortschritte der Neurologie-Psychiatrie
2025

Whipple's Disease as a Differential Diagnosis of Blood Culture-Negative Endocarditis: A Case Report.

Arquivos brasileiros de cardiologia
2025

Spondylodiscitis revealing Whipple disease.

Skeletal radiology
2025

Severe pneumonia caused by Legionella pneumophila associated with Tropheryma whipplei: A case report.

Medicine
2024

Whipple Disease With Central Nervous System Involvement.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS
2025

Diagnosis of Tropheryma whipplei pneumonia in an immunocompromised lymphoma patient using metagenomic next generation sequencing: A case report.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy
2025

Crystal-Storing Histiocytosis of the Duodenum in a Patient With IgG-Lambda Multiple Myeloma.

International journal of surgical pathology
2025

Whipple Disease Initial Presentation as Supraclavicular Lymphadenopathy in a Patient With Rheumatoid Arthritis: A Diagnostic Challenge.

International journal of surgical pathology
2025

Application of metagenomic next-generation sequencing in the diagnosis and treatment of acute pneumonia caused by Tropheryma whipplei.

BMC pulmonary medicine
2025

Tropheryma whipplei Infections, Mexico, 2019-2021.

Emerging infectious diseases
2025

Isolated joint involvement in Whipple's disease: a cohort study.

European journal of internal medicine
2025

Human genetics of Whipple's disease.

Current opinion in rheumatology
2025

Eyelid abscess as an initial manifestation of whipple's disease: a case report and comprehensive literature review.

BMC ophthalmology
2025

Fading Away: A Case Report on Whipple's Disease.

Cureus
2025

Whipple's disease in a patient with follicular lymphoma.

Diagnostic microbiology and infectious disease
2025

Oral treatment of Whipple's disease with doxycycline and hydroxychloroquine versus intravenous therapy with ceftriaxone followed by oral trimethoprim-sulfamethoxazole in Germany: a phase 2/3, prospective, open-label, randomised, controlled, non-inferiority trial.

The Lancet. Infectious diseases
2025

Case Report: 18 F-FDG PET/CT for FUO Due to Whipple Disease Infection.

Clinical nuclear medicine
2024

Pulmonary infection caused by Tropheryma whipplei: a case report and review of the literature.

Journal of medical case reports
2024

Progressive Uveitis as a Diagnostic and Therapeutic Challenge in Whipple's Disease.

Cureus
2024

Pangenome analysis of five representative Tropheryma whipplei strains following multiepitope-based vaccine design via immunoinformatic approaches.

Molecular genetics and genomics : MGG
2024

Infectious leukoencephalopathies.

Handbook of clinical neurology
2024

Development of novel broad-range pan-genus PCR assays for the detection of Tropheryma species.

Journal of medical microbiology
2024

A rare case of Whipple disease presenting as a hydrosalpinx and granulomatous peritonitis.

Journal of infection in developing countries
2024

Classic Whipple disease presenting as genuine pyrexia of unknown origin following immunosuppression with adalimumab.

BMJ case reports
2025

Whipple disease diagnosed through minimally invasive ultrasound-guided synovial biopsy.

Rheumatology (Oxford, England)
2024

Valvular Endocarditis and Biventricular Heart Failure in the Setting of Tropheryma whipplei Disease.

Texas Heart Institute journal
2024

[Bilateral panuveitis in Whipple's disease: Case report].

Journal francais d'ophtalmologie
2024

An Unusual Case of Limbic Encephalitis Caused by Whipple Disease.

Cureus
2024

Tropheryma whipplei Colonization in Adults and Children: A Prospective Study.

Microorganisms
2024

Tropheryma whipplei pneumonia revealed by Metagenomic next-generation sequencing: Report of two cases.

Diagnostic microbiology and infectious disease
2025

Is PAS Stain Necessary to Exclude Whipple Disease in Duodenal Biopsies?

International journal of surgical pathology
2024

Very Low-density Lymphadenopathy in Whipple Disease.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
2024

Incidental Mixed Adenoma-Neuroendocrine Neoplasm (MiNEN) of Duodenum and Whipple Disease.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
2024

Tropheryma whipplei detected by metagenomic next-generation sequencing in bronchoalveolar lavage fluid.

Diagnostic microbiology and infectious disease
2024

Novel Patterns in High-Resolution Computed Tomography in Whipple Pneumonia.

Emerging infectious diseases
2024

Prolonged arthralgias in Whipple's disease - A common but often overlooked symptom of a rare disease.

The journal of the Royal College of Physicians of Edinburgh
2024

Generalized lymphadenopathy due to Tropheryma whipplei: Thinking outside the box!

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2024

Whipple Disease Presenting as Isolated Transverse Myelitis with Permanent Neurological Damage in a Patient with Systemic Lupus Erythematosus: A Case Report of a Difficult Diagnosis with a Literature Review.

Infectious disease reports
2024

Whipple's Disease Presenting With a Chief Complaint of Dyspnea and Cough From Pulmonary Invasion Without Evidence of Gastrointestinal Involvement.

Cureus
2024

Concomitant Tuberculous and Lepromatous Lymphadenitis: Clues and Pitfalls of Leprosy Concealed by Tuberculosis in Lymph Nodes.

International journal of surgical pathology
2024

From palliative care to a definite cure: a presentation of severe Whipple disease.

Gastrointestinal endoscopy
2024

[Endocarditis and ischemic stroke of rare cause].

Innere Medizin (Heidelberg, Germany)
2024

Lyme disease and Whipple's disease: a comprehensive review for the rheumatologist.

Advances in rheumatology (London, England)
2024

A 40-Year-Old Man with a 7-Year History of Polyarthritis and a Late Diagnosis of Whipple Disease: A Journey to Resolve the Mystery.

The American journal of case reports
2024

Tropheryma whipplei Endocarditis Presenting as Valvulopathy and Multiple Septic Emboli.

Journal of general internal medicine
2023

Genotyping of Whipple's disease presenting as sclerosing mesenteritis: A case report.

Germs
2024

Diagnosis and treatment of Tropheryma whipplei infection in patients with inflammatory rheumatic disease: Data from the French Tw-IRD registry.

The Journal of infection
2024

Whipple's disease: A rare disease that can be spotted by many doctors.

European journal of internal medicine
2024

Whipple's disease in the elderly.

Gastroenterologia y hepatologia
2024

A serological assay using Tropheryma whipplei antigens for the presumptive exclusion of Whipple disease.

Pathology
2024

Ocular Whipple Disease: Cases Diagnosed Over Four Decades.

Ocular immunology and inflammation
2023

Current knowledge of the immune reconstitution inflammatory syndrome in Whipple disease: a review.

Frontiers in immunology
2023

Use of bevacizumab in a patient with Whipple's disease: managing diagnostic uncertainty.

BMJ case reports
2023

Chronic Whipple's disease, a diagnostic challenge for the cardiologist.

Revista espanola de cardiologia (English ed.)
2024

Non-convulsive status epilepticus associated with Whipple's disease.

Practical neurology
2024

Ophthalmic manifestations of Whipple's disease.

Current opinion in ophthalmology
2023

Whipple Disease Misdiagnosed as Lymphoma by 18 F-FDG PET/CT: A Case Study.

Clinical nuclear medicine
2023

Diagnosis and treatment of Whipple disease after kidney transplantation: A case report.

World journal of clinical cases
2023

Clinical and laboratory predictors and prevalence of immune reconstitution inflammatory syndrome in patients with Whipple's disease.

Journal of digestive diseases
2023

Whipple's Disease; An Overlooked Diagnosis.

Middle East journal of digestive diseases
2024

A Case of Whipple's Disease With Concomitant Esophageal Candidiasis.

Military medicine
2023

A Case Report of Whipple's Disease: A Challenging Diagnosis.

Cureus
2024

Susceptibility of nucleotide-binding oligomerization domain 2 mutations to Whipple's disease.

Rheumatology (Oxford, England)
2023

Two consecutive cases of mycotic aneurysms resulting from Whipple disease.

Journal of vascular surgery cases and innovative techniques
2023

[Co-occurrence of Whipple's disease and hyperparathyroidism - coincidence or causal relationship?].

Zeitschrift fur Gastroenterologie
2023

Gastrointestinal: Whipple's disease: Often taught but rarely seen and diagnosed late.

Journal of gastroenterology and hepatology
2023

Whipple's disease-associated infective endocarditis: a systematic review.

Infectious diseases (London, England)
2023

Whipple's disease presenting as weight gain and constipation in a Chinese woman.

BMC infectious diseases
2023

Prosthetic valve endocarditis secondary to Tropheryma whipplei in a patient with chronic polyarthritis.

Journal of cardiothoracic surgery
2023

An unusual presentation of a rare disease: acute upper limb ischemia as the presenting symptom of Whipple's Endocarditis, a case report.

BMC infectious diseases
2023

Whipple's Disease - delay of diagnosis by immunosuppressive therapy; a case-series report.

Zeitschrift fur Gastroenterologie
2023

[Whipple's disease, a non-rheumatoid cause of seronegative arthritis].

Nederlands tijdschrift voor geneeskunde
2023

Patients with Whipple's disease have a high prevalence of Helicobacter pylori infection.

European journal of internal medicine
2023

Why Is Whipple's Disease Still a Challenging Diagnosis? A Case Report and Brief Review of Literature.

Cureus
2024

Whipple Disease and Orbital Inflammatory Syndrome-A Case Report.

Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society
2023

Contribution of PCR to Differential Diagnosis between Patients with Whipple Disease and Tropheryma whipplei Carriers.

Journal of clinical microbiology
2022

Orbital Manifestation of Immune Reconstitution Inflammatory Syndrome in Whipple's Disease.

Deutsches Arzteblatt international
2022

Whipple's disease review, prevalence, mortality, and characteristics in the United States: A cross-sectional national inpatient study.

Medicine
2023

[Massive pancarditis-autopsy report].

Pathologie (Heidelberg, Germany)
2023

[Whipple's disease with multiple presentation in a rheumatologic patient].

Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia
2023

Humoral immunogenicity of COVID-19 vaccines in patients with coeliac disease and other noncoeliac enteropathies compared to healthy controls.

European journal of gastroenterology &amp; hepatology
2023

Emergence of Tropheryma whipplei detection in respiratory samples by next-generation sequencing: Pathogen or innocent bystander?

The Journal of infection
2024

Whipple's disease - A typical endoscopic finding of a rare disease.

Revista espanola de enfermedades digestivas
2023

Imaging of Uncommon Bacterial, Rickettsia, Spirochete, and Fungal Infections.

Neuroimaging clinics of North America
2022

Bacterial infection possibly causing autoimmunity: Tropheryma whipplei and membranous nephropathy.

Lancet (London, England)
2022

Isolated central nervous system Whipple disease.

Surgical neurology international
2022

Whipple's disease: a rare cause of sacroiliitis.

RMD open
2022

Tropheryma whipplei Intestinal Colonization in Migrant Children, Greece.

Emerging infectious diseases
2022

The Brief Case: Tropheryma whipplei Infection Resulting in Neurological Symptoms.

Journal of clinical microbiology
2022

Closing the Brief Case: Tropheryma whipplei Infection Resulting in Neurological Symptoms.

Journal of clinical microbiology
2022

Whipple's disease unmasked by TNF inhibitor therapy for treatment of seronegative rheumatoid arthritis.

BMJ case reports
2022

A Massive Number of Extracellular Tropheryma whipplei in Infective Endocarditis: A Case Report and Literature Review.

Frontiers in immunology
2022

Whipple's disease with normal duodenal histology diagnosed by ileal biopsy using balloon endoscopy.

Clinical journal of gastroenterology
2022

Central Nervous System Whipple Disease Presenting as Hypersomnolence.

Cureus
2022

Intestinal barrier dysfunction mediates Whipple's disease immune reconstitution inflammatory syndrome (IRIS).

Immunity, inflammation and disease
2022

Whipple's disease and Tropheryma whipplei infections: from bench to bedside.

The Lancet. Infectious diseases
2023

[Chronic Tropheryma whipplei infection: an important differential diagnosis of refractory polyarthritis].

Zeitschrift fur Rheumatologie
2022

Whipple's disease: a case report in Santa Catarina, Brazil.

Le infezioni in medicina
2022

Endoscopic diagnosis of Whipple disease in a patient without gastrointestinal symptoms: A case report.

DEN open
2022

Tropheryma whipplei in the stool samples of children with acute diarrhea: a study from Tehran, Iran.

BMC infectious diseases
2022

Subcutaneous Nodules Caused by Tropheryma whipplei Infection.

Emerging infectious diseases
2022

Whipple's disease - a rare and challenging complication in a patient with Crohn's disease.

Zeitschrift fur Gastroenterologie
2022

Recurrent thrombosis as a clinical presentation of Whipple disease.

BMJ case reports
2022

Whipple Disease: An Atypical Diagnosis by Capsule Endoscopy in an Oldest-Old Patient.

GE Portuguese journal of gastroenterology
2022

Challenging case of Whipple's disease: The contribution of radiology.

Radiology case reports
2022

Rapidly progressive dementia and intractable diarrhea: a teaching case report and a systematic review of cognitive impairment in Whipple's disease.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2021

Role of enteroscopy in the diagnosis of whipple's disease.

Acta gastro-enterologica Belgica
2021

Whipple disease mimicking polymyalgia rheumatica with initial response to tocilizumab.

Internal medicine journal
2022

Whipple's disease in renal transplant recipients: Management experience of seven cases from Pakistan.

Transplant infectious disease : an official journal of the Transplantation Society
2021

Severe Pneumonia Caused by Infection With Tropheryma whipplei Complicated With Acinetobacter baumannii Infection: A Case Report Involving a Young Woman.

Frontiers in public health
2022

Balloon endoscopy and capsule endoscopy are useful in the diagnosis of small bowel lesions in Whipple's disease.

Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
2021

Whipple's disease: Rare case of malabsorption with hyperpigmentation in a female.

Indian journal of pathology &amp; microbiology
2021

Tropheryma whipplei intestinal colonization in immunocompromised children in Iran: a preliminary study.

Future microbiology
2021

Mycobacterium avium Complex Infection Imitating Whipple Disease in an Immunocompromised Patient With Newly Diagnosed Acquired Immunodeficiency Syndrome.

ACG case reports journal
2021

Recurrent Valvular Vegetation: Fooled Me Once, But Won't Fool Me Twice.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2021

Publisher Correction: Rheumatological features of Whipple disease.

Scientific reports
2021

Whipple's disease: a fatal mimic.

Autopsy &amp; case reports
2021

[Diagnostic issues of Whipple's disease during chronic inflammatory rheumatism: About three cases].

La Revue de medecine interne
2021

Phenotypic diversity of Tropheryma whipplei clinical isolates.

Microbial pathogenesis
2021

Granulomatous lung disease and immune reconstitution inflammatory syndrome in Whipple's disease.

BMJ case reports
2022

Beware of Histiocytes: Whipple Adenopathy and its Mimics.

International journal of surgical pathology
2021

Detection of Tropheryma whipplei Genome From the Aqueous Humor by Metagenomic Sequencing.

Annals of internal medicine
2021

Rheumatological features of Whipple disease.

Scientific reports
2021

Tumor Necrosis Factor Inhibitors Exacerbate Whipple's Disease by Reprogramming Macrophage and Inducing Apoptosis.

Frontiers in immunology
2021

Whipple's Disease Mimicking Common Digestive Disorders.

Rhode Island medical journal (2013)
2021

Hepatobiliary Manifestations of Whipple Disease.

Clinical liver disease
2021

Persistence of Facio-Skeletal Myorhythmia During Sleep in anti-IgLON5 Disease.

Movement disorders clinical practice
2021

The Effect of Tocilizumab on Inflammatory Markers in Patients Hospitalized with Serious Infections. Case Series and Review of Literature.

Life (Basel, Switzerland)
2021

Whipple's disease diagnosed in a patient with suspected sarcoidosis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2021

Whipple's disease: the great masquerader-a high level of suspicion is the key to diagnosis.

BMC gastroenterology
2021

Differential diagnostic value of rheumatic symptoms in patients with Whipple's disease.

Scientific reports
2021

Tropheryma whipplei endocarditis.

Echocardiography (Mount Kisco, N.Y.)
2021

Tropheryma whipplei in Feces of Patients with Diarrhea in 3 Locations on Different Continents.

Emerging infectious diseases
2021

[Whipple's disease and reversible pulmonary hypertension].

Medicina
2021

A Case of Whipple Disease With Cutaneous Manifestations.

The American Journal of dermatopathology
2021

Human galectin-1 and galectin-3 promote Tropheryma whipplei infection.

Gut microbes
2022

Unique Features of Posterior Ocular Involvement of Whipple's Disease in a Patient with No Gastrointestinal Symptoms.

Ocular immunology and inflammation
2021

Severe pneumonia in adults caused by Tropheryma whipplei and Candida sp. infection: a 2019 case series.

BMC pulmonary medicine
2021

[Whipple disease - systemic disease with gastrointestinal manifestations].

Vnitrni lekarstvi
2021

Tropheryma whipplei: an unusual cause of the accumulation in positron emission tomography.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2020

Mesenteric panniculitis as a presentation of Whipple's disease: case report and review of the literature.

Acta gastro-enterologica Belgica
2021

[A 3-week history of intestinal symptoms in a 67-year-old male patient with chronic arthralgia].

Der Internist
2020

Case Report: Tropheryma whipplei Infection Presenting with Optic Disc Edema.

Optometry and vision science : official publication of the American Academy of Optometry
2020

Gastrointestinal and renal involvement in systemic vasculitis.

Revista espanola de enfermedades digestivas
2020

[Unmasking of Whipples disease after start of prednisolone therapy].

Ugeskrift for laeger
2021

Reversible pulmonary hypertension associated with multivisceral Whipple's disease.

The European respiratory journal
2021

Erythematous skin nodules during treatment of Whipple's disease.

Infectious diseases now
2020

Whipple's disease scleral nodules: a novel presentation in 2 consecutive patients.

BMC ophthalmology
2022

Whipple's disease orbitopathy: case report and review of literature.

Orbit (Amsterdam, Netherlands)
2021

Whipple disease: a 15-year retrospective study on 36 patients with positive polymerase chain reaction for Tropheryma whipplei.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2021

Resolution of Weight Loss, Systemic Illness, and Fever after Triple Therapy: A Surprising Response to Treatment of Positive Urease Test.

Gastroenterology
2021

[Whipple's disease - a challenge for ultrasound].

Ultraschall in der Medizin (Stuttgart, Germany : 1980)
2020

Lessons from practice Low attenuation lymphadenopathy on computed tomography leading to diagnosis of Whipple disease.

The Medical journal of Australia
2020

Long-term morbidity and mortality in Whipple's disease: a single-center experience over 20 years.

Future microbiology
2021

Whipple Disease and Ankylosing Spondylitis-A Case Report.

Journal of clinical rheumatology : practical reports on rheumatic &amp; musculoskeletal diseases
2021

Whipple disease mimicking inflammatory bowel disease.

Intestinal research
2020

Whipple disease diagnosed by enteroscopy: first case report in Colombia of an underdiagnosed disease and literature review.

BMC gastroenterology
2020

Tropheryma Whipplei infection mimicking giant cell arteritis flare in a patient treated with interleukin-6 receptor blocker tocilizumab.

Clinical and experimental rheumatology
2020

Unusual effectiveness of systemic steroids in Whipple disease.

Pulmonology
2020

Tropheryma whipplei endocarditis: An uncommon infection with potentially fatal consequences.

Journal of cardiac surgery
2020

Whipple's disease: imaging contribution for a challenging case.

BMJ case reports
2020

Pearls & Oy-sters: A rare presentation of Whipple disease: Still waters run deep.

Neurology
2020

Chronic bursitis and tenosynovitis revealing Whipple's disease.

Joint bone spine
2020

Thrombocytopenia and endocarditis in a patient with Whipple's disease: case report.

BMC infectious diseases
2020

A Rare Cause of Chronic Diarrhea and Fever.

Gastroenterology
2020

Fever, Diarrhea, and Weight Loss in a Man With Inflammatory Polyarthritis.

JAMA
2019

Another Whipple's triad? Pericardial, myocardial and valvular disease in an unusual case presentation from a Canadian perspective.

BMC cardiovascular disorders
2020

A case of Whipple's disease mimicking auto-inflammatory disease and revealed by severe right cardiac failure under anakinra.

Joint bone spine
2020

Endoscopic electrohydraulic lithotripsy of an enterolith causing afferent loop syndrome after Whipple's operation.

Endoscopy
2020

Whipple's disease: diagnosis and predictive factors of relapse.

European journal of gastroenterology &amp; hepatology
2019

Seronegative Arthritis and Whipple Disease: Risk of Misdiagnosis in the Era of Biologic Agents.

Case reports in rheumatology
2019

Abdominal Pain, Fevers, and Intestinal Lymphangiectasia.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2019

Freiburg Neuropathology Case Conference : A Progressive Lesion of the Optic Tract, Brainstem, Hypothalamus and Basal Ganglia.

Clinical neuroradiology
2020

Wither Away: Weight Loss and Persistent Inflammation in a Woman With Whipple Disease.

The American journal of medicine
2019

Diagnostic vitrectomy: a case series in a single referral center.

Archivos de la Sociedad Espanola de Oftalmologia
2019

Primary Whipple disease of the Central Nervous System presenting with rhombencephalitis.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2019

Fatal Whipple's disease with severe mental manifestations on relapse - case report and brief advances update.

Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie
Ver todos os 223 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Clinical experience with metagenomic next-generation sequencing (mNGS) for the detection of Tropheryma whipplei in respiratory specimens: A multicenter retrospective observational study.
    International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases· 2026· PMID 41654251mais citado
  2. Deciphering whipple's disease complexity.
    Clinical and experimental medicine· 2026· PMID 41649590mais citado
  3. Whipple's Disease: Panniculitis Among Other Dermatoses. A Case Report and Literature Review.
    Journal of cutaneous pathology· 2026· PMID 41631710mais citado
  4. Tropheryma whipplei Infection Presenting Initially with Chest Pain.
    Clinical laboratory· 2026· PMID 41543108mais citado
  5. Atypical Migrating Nummular Retinal Lesions in an Immunosuppressed Patient With Whipple Disease.
    ACG case reports journal· 2026· PMID 41503173mais citado
  6. Clinical features of Tropheryma Whipplei in pediatric pneumonia: an mNGS and tNGS-based case-control study.
    Front Cell Infect Microbiol· 2026· PMID 41924426recente
  7. When it's not RA: unmasking Whipple's disease in seronegative, difficult-to-treat rheumatoid arthritis.
    Clin Rheumatol· 2026· PMID 41483077recente
  8. Interplay of multiple neurological conditions - the first case of neurological Whipple's disease in Syria: a case report.
    Ann Med Surg (Lond)· 2025· PMID 41377310recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:3452(Orphanet)
  2. MONDO:0005116(MONDO)
  3. GARD:7889(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Busca completa no PubMed(PubMed)
  6. Artigo Wikipedia(Wikipedia)
  7. Q653078(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Doença de Whipple
Compêndio · Raras BR

Doença de Whipple

ORPHA:3452 · MONDO:0005116
Prevalência
Unknown
Herança
Not applicable
CID-10
M14.8* · Artropatias em outras doenças classificadas em outra parte
CID-11
Início
No data available
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0023788
EuropePMC
Wikidata
Wikipedia
Papers 10a
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