O Linfoma Não-Hodgkin (LNH) é diferente do Linfoma de Hodgkin tanto na sua aparência quanto no seu funcionamento. Uma de suas principais características é a falta das células de Reed-Sternberg. Pode aparecer em qualquer idade e geralmente se manifesta com o inchaço dos gânglios (linfonodos), seja em uma área específica ou espalhado pelo corpo, acompanhado de febre e perda de peso. A forma como a doença evolui varia de acordo com o tipo de célula envolvida. Clinicamente, o LNH é classificado como indolente (de crescimento lento), agressivo (de crescimento rápido) ou com uma evolução variável. O LNH pode ter origem em diferentes tipos de células, como as células B, T ou NK.
Introdução
O que você precisa saber de cara
O Linfoma maligno não-Hodgkin é um tipo de câncer do sistema linfático que surge pela multiplicação desordenada de células de defesa do organismo. Ele pode provocar aumento dos gânglios linfáticos, perda sem motivo de peso corporal, febre, calafrios e lesões na pele. Essa condição não conta com um Protocolo Clínico e Diretrizes Terapêuticas (PCDT) na lista oficial de doenças raras do Ministério da Saúde. No Brasil, medicamentos específicos contam com registro na ANVISA, e a assistência aos pacientes deve ser buscada na rede de atendimento do SUS.
O Linfoma Não-Hodgkin (LNH) é diferente do Linfoma de Hodgkin tanto na sua aparência quanto no seu funcionamento. Uma de suas principais características é a falta das células de Reed-Sternberg. Pode aparecer em qualquer idade e geralmente se manifesta com o inchaço dos gânglios (linfonodos), seja em uma área específica ou espalhado pelo corpo, acompanhado de febre e perda de peso. A forma como a doença evolui varia de acordo com o tipo de célula envolvida. Clinicamente, o LNH é classificado como indolente (de crescimento lento), agressivo (de crescimento rápido) ou com uma evolução variável. O LNH pode ter origem em diferentes tipos de células, como as células B, T ou NK.
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1/20kRara
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1/5kIncomum
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 49 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 133 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
47 genes identificados com associação a esta condição.
Leukemia, chronic lymphocytic
A chronic leukemia in which functionally incompetent B-lymphocytes progressively accumulate in the bone marrow, blood, and lymphoid tissues. The clinical evolution of the disorder is heterogeneous, with some patients having indolent disease and others having aggressive disease and short survival.
Immunodeficiency 84
An autosomal recessive immunologic disorder characterized by recurrent sinopulmonary infections from childhood associated with low levels of B cells and impaired early B-cell development. There may also be variable T-cell abnormalities. Patients have increased susceptibility to infection with Epstein-Barr virus and a propensity for the development of lymphoma in adulthood.
Congenital anomalies of kidney and urinary tract syndrome with or without hearing loss, abnormal ears, or developmental delay
An autosomal dominant disorder characterized by variable congenital anomalies of the kidney and urinary tract, sometimes resulting in renal dysfunction or failure, dysmorphic facial features, and abnormalities of the outer ear. Most patients have hearing loss, and some may have global developmental delay.
Intellectual developmental disorder, autosomal dominant 26
A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Additional MRD26 features include autism, short stature, microcephaly, cerebral palsy, and facial dysmorphisms.
Skeletal defects, genital hypoplasia, and impaired intellectual development
A disorder characterized by intellectual disability, craniofacial dysmorphism, microcephaly and short stature. Additional features include absence of the thumbs, hypoplasia of the radii and ulnae, additional vertebrae and ribs, retarded bone age and genital hypoplasia.
Immunodeficiency 123 with HPV-related verrucosis
An autosomal recessive immunologic disorder characterized by susceptibility to human papilloma virus (HPV) infections and the development of HPV-related common verrucosis in the first decade of life. In some patients with HPV2 infection, warts may progress to severe generalized hyperkeratotic cutaneous papillomatosis with cutaneous horns ('tree-man' phenotype). In patients with HPV4 infection, warts remains stable and may even regress with age.
Systemic lupus erythematosus
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Autoinflammation, immune dysregulation, and eosinophilia
An autosomal dominant disorder characterized by immune dysregulation, severe atopic dermatitis, and chronic gastrointestinal inflammation. Additional features include asthma, food or environmental allergies, as well as poor overall growth with short stature.
Breast cancer
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Multiple myeloma
A malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia.
Tumor predisposition syndrome 3
An autosomal dominant disorder characterized by an increased risk for the development of various types of benign and malignant neoplasms throughout life, with age-dependent penetrance. Affected individuals can develop neoplasms involving epithelial, mesenchymal, and neuronal tissues, as well as lymphoid and myeloid cancers. The disorder is associated with elongated telomeres.
Breast cancer
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Immunodeficiency 35
A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
Ataxia telangiectasia
A rare recessive disorder characterized by progressive cerebellar ataxia, dilation of the blood vessels in the conjunctiva and eyeballs, immunodeficiency, growth retardation and sexual immaturity. Patients have a strong predisposition to cancer; about 30% of patients develop tumors, particularly lymphomas and leukemias. Cells from affected individuals are highly sensitive to damage by ionizing radiation and resistant to inhibition of DNA synthesis following irradiation.
Hyper-IgE syndrome 1, autosomal dominant, with recurrent infections
A rare disorder of immunity and connective tissue characterized by immunodeficiency, chronic eosinophilia, distinctive coarse facial appearance, abnormal dentition, hyperextensibility of the joints, and bone fractures.
Immunodeficiency 68
An autosomal recessive primary immunodeficiency characterized by life-threatening, often recurrent, pyogenic bacterial infections, including invasive pneumococcal disease, beginning in infancy or early childhood.
Autoimmune lymphoproliferative syndrome 2A
A disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.
Hemophagocytic lymphohistiocytosis, familial, 2
A rare disorder characterized by immune dysregulation with hypercytokinemia, defective function of natural killer cell, and massive infiltration of several organs by activated lymphocytes and macrophages. The clinical features of the disease include fever, hepatosplenomegaly, cytopenia, and less frequently neurological abnormalities ranging from irritability and hypotonia to seizures, cranial nerve deficits and ataxia.
Medicamentos aprovados (FDA)
3 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
4.949 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 14 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
346 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Linfoma maligno não-Hodgkin
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 8.936
[Clinical analysis of 49 cases of malignant lymphoma of the head and neck in children].
Objective:To analyze the clinical characteristics of malignant lymphoma of the head and neck in children, and to improve the understanding and diagnosis and treatment of this type of disease by otolaryngologists. Methods:Clinical data of 49 children with malignant lymphoma of the head and neck hospitalized in the Department of Otorhinolaryngology, Head and Neck Surgery of Kunming Children's Hospital from 2013-2021 were retrospectively analyzed and statistically analyzed according to gender, age distribution, duration of the disease, site of onset, type of pathology and survival status. Results:A total of 49 cases of malignant lymphoma of the head and neck in children were collected, of which, 39 were male and 10 female. The minimum age was 3 years, the maximum was 14 years and 4 months, the median age of onset was 7 years, and the largest percentage （51.02%） of children was in the school age（6-12 years）. The duration of the disease ranged from 5 days to 2 years, with a median of 1 month, and the site of the lesion was located in the neck in the majority of cases, 41（83.67%）. The pathologic types of hodgkin lymphoma（HL） were 25 cases（51.02%） and non-hodgkin lymphoma（NHL） were 24 cases（48.98%）, and among hodgkin lymphomas, mixed-cell classical hodgkin lymphoma was the most common, with 9 cases（18.37%）; among non-hodgkin lymphomas,originated from B-cells in 16 cases （32.65%） and from T-cells in 7 cases （14.29%）, with Burkitt's lymphoma being the most numerous of B-cell origin in 13 cases （26.53%）, and T-cell lymphoblastoid lymphoma being the most common of T-cell origin in 4 cases （8.16%）. The follow-up period was from 22 days to 6 years and 10 months, with 3 cases losing, 43 cases surviving, 3 cases dying, with a survival rate of 93<unk> 5%, and 3 cases relapsing, with a relapse rate of 6<unk> 5%. Conclusion:Children's head and neck malignant lymphoma has its own characteristics in terms of age of onset, gender distribution, site of onset, pathological type and treatment prognosis, which should be comprehensively assessed, diagnosed as early as possible, and multidisciplinary joint treatment actively carried out to propose personalized treatment plans. 目的：分析儿童头颈部恶性淋巴瘤的临床特点，提升耳鼻喉科医生对该类疾病的认识和诊疗水平。 方法：回顾性分析2013至2021年昆明市儿童医院耳鼻咽喉头颈外科住院治疗的49例头颈部恶性淋巴瘤患儿的临床资料，按照性别、年龄分布、病程、发病部位、病理类型及生存状态进行统计学分析。 结果：共收集儿童头颈部恶性淋巴瘤病例49例，其中，男39例，女10例；年龄最小3岁，最大14岁4个月，中位发病年龄7岁，学龄期（6～12岁）患儿的占比最大（51.02%）。病程在5 d～2年，中位数1个月，病变部位位于颈部者占绝大多数，为41例（83.67%）。病理类型中霍奇金淋巴瘤（hodgkin lymphoma，HL）25例（51.02%），非霍奇金淋巴瘤（non-hodgkin lymphoma，NHL）24例（48.98%），HL中又以混合细胞型经典HL最多，为9例（18.37%）；NHL中起源于B细胞者16例（32.65%），起源于T细胞者7例（14.29%），B细胞来源以Burkitt淋巴瘤数量最多，为13例（26.53%），T细胞来源以T细胞淋巴母细胞淋巴瘤最多见，为4例（8.16%）。随访时间为22 d～6年10个月，失访3例，存活43例，死亡3例，生存率93.5%，复发3例，复发率6.5%。 结论：儿童头颈部恶性淋巴瘤的发病年龄、性别分布、发病部位、病理类型及治疗预后都有其自身特点，应对其综合评估，尽早诊断，积极开展多学科联合治疗，提出个性化的治疗方案。.
Evaluation of ovarian functions in girls treated for hematological malignancy.
Acute lymphoblastic leukemia (ALL) and other hematological malignancies are the most common cancers in children, with chemotherapy and/or radiotherapy as the primary treatment options. These treatments, however, may have long-term effects on ovarian function and fertility in female survivors. This study aims to evaluate ovarian function and reserve in female survivors of childhood hematological malignancies by assessing hormonal markers and ovarian follicle count. This cross-sectional study included 30 female survivors of acute leukemia, non-Hodgkin lymphoma (NHL), and Hodgkin lymphoma (HL) who completed chemotherapy between 2013 and 2023. Hormonal markers including anti-Müllerian hormone (AMH), inhibin B, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), and ovarian follicle counts were measured. Statistical analysis was performed using SPSS, with a significance level of p < 0.05. Out of 263 patients diagnosed with hematological malignancies during the study period, 30 female patients were included. The median age at diagnosis was 14 years (range: 7-24 years). The malignancy breakdown was as follows: 7 patients (23.3%) with ALL, 2 patients (6.7%) with acute myeloid leukemia (AML), 9 patients (30%) with HL, and 12 patients (40%) with NHL. The median number of right ovarian follicles was 6 (range: 0-13), and the median number of left ovarian follicles was 7 (range: 2-12), with a total median follicle count of 12.5 (range: 5-25). AMH levels were normal in 26 patients (86.7%) and low in 3 patients (10%), with 3 patients (10%) diagnosed with decreased ovarian reserve (DOR), defined by AMH levels < 0.96 ng/mL. Inhibin-B levels were normal in 25 patients (83.3%), elevated in 1 patient (3.3%), and low in 4 patients (13.3%). Significant correlations were found between AMH and inhibin-B (p = 0.005, r = 0.508), FSH and inhibin-B (p = 0.041, r = 0.375), and inhibin-B and total follicle count (p = 0.014, r = 0.444). Additionally, a significant modarate correlation between AMH levels and total follicle count was observed (p = 0.033, r = 0.396). The evaluation of ovarian reserve using AMH, inhibin B, and ovarian follicle counts provides critical insights for fertility planning in survivors of childhood cancer. Early and comprehensive assessments may improve reproductive outcomes and quality of life for these patients.
Fertility preservation counselling and practice among women with lymphomas: a retrospective study.
Research on fertility preservation among women diagnosed with lymphoma is very limited. We aimed to assess the receipt of fertility preservation information and use of fertility preservation among women diagnosed with lymphoma. This was a retrospective, single-centre study. Patients with Hodgkin and non-Hodgkin lymphoma were screened from the electronic medical records of individuals who attended the Haematology Department at the study site between 2000 and 2018 and were followed-up for obstetric outcomes and onset of menopause until December 2023. Forty-three patients had available electronic health records. Overall, 13 (36.1%) of the 36 patients ≤45 years old received fertility preservation counselling; it was more frequent among nulliparous women (11/23, 47.8%), women aged ≤35 years (11/26, 42.3%), and those diagnosed in the latest study period from 2015 to 2018 (9/16, 56.3%). Of the 13 patients who were informed about fertility preservation, 2 patients refused this intervention, and fertility preservation was contraindicated for 3 patients, leading to a total of eight women who underwent fertility preservation strategies: six underwent ovarian cortex cryopreservation, and two underwent oocyte vitrification. Among the participants aged ≤45 years, 10 (27.8%) had at least one live birth after diagnosis. Fifteen (34.9%) of the 43 participants exhibited amenorrhoea after the initiation of chemotherapy, including 4 women ≤35 years of age. The median (range) age at menopause in this series was 45 (27-50) years. Even though the situation appears to have improved in recent years, we are far from reaching the target of all women with lymphoma who are of reproductive age receiving fertility preservation counselling before initiating chemotherapy. If you have cancer and/or receiving certain types of cancer treatment, fertility can be threatened. You might want to consider freezing your eggs or embryos or any other technique to preserve your fertility. For this reason, scientific societies recommend that all women diagnosed with cancer be informed about the impact of the disease and its treatment on fertility and receive fertility preservation counselling from healthcare professionals. In this study, we aimed to assess the receipt of fertility preservation information and use of fertility preservation among women diagnosed with lymphoma in our centre. Of the 36 women diagnosed with lymphoma who were 45 years or younger, only 13 (36%) had received fertility preservation counselling, and among them, only two refused fertility preservation intervention. Although the situation has improved in recent years, it seems that we are far from the recommendation to inform all women with lymphoma about fertility preservation.
Update: The molecular spectrum of virus-associated high-grade B-cell non-Hodgkin lymphomas.
The vast spectrum of aggressive B-cell non-Hodgkin neoplasms (B-NHL) encompasses several infrequent entities occurring in association with viral infections, posing diagnostic challenges for practitioners. In the emerging era of precision oncology, the molecular characterization of malignancies has acquired paramount significance. The pathophysiological comprehension of specific entities and the identification of targeted therapeutic options have seen rapid development. However, owing to their rarity, not all entities have undergone exhaustive molecular characterization. Considerable heterogeneity exists in the extant body of work, both in terms of employed methodologies and the scale of cases studied. Presently, therapeutic strategies are predominantly derived from observations in diffuse large B-cell lymphoma (DLBCL), the most prevalent subset of aggressive B-NHL. Ongoing investigations into the molecular profiles of these uncommon virus-associated entities are progressively facilitating a clearer distinction from DLBCL, ultimately paving the way towards individualized therapeutic approaches. This review consolidates the current molecular insights into aggressive and virus-associated B-NHL, taking into consideration the recently updated 5th edition of the WHO classification of hematolymphoid tumors (WHO-5HAEM) and the International Consensus Classification (ICC). Additionally, potential therapeutically targetable susceptibilities are highlighted, offering a comprehensive overview of the present scientific landscape in the field.
Gastric microbiota in patients with gastric MALT lymphoma according to Helicobacter pylori infection.
Gastric Mucosa Associated Lymphoid Tissue lymphoma (GML) development is triggered by Helicobacter pylori (H. pylori) infection. Little is known about the impact of H. pylori infection on gastric microbiota. The gastric microbiota was retrospectively investigated using 16S rRNA gene sequencing in 32 patients with untreated GML (10 H. pylori-positive and 22 H. pylori-negative), 23 with remitted and 18 refractory GML and 35 controls. Differences in microbial diversity, bacterial composition and taxonomic repartition were assessed. There was no change in diversity and bacterial composition between GML and control patients taking into account H. pylori status. Differential taxa analysis identified specific changes associated with H. pylori-negative GML: the abundances of Actinobacillus, Lactobacillus and Chryseobacterium were increased while the abundances of Veillonella, Atopobium, Leptotrichia, Catonella, Filifactor and Escherichia_Shigella were increased in control patients. In patients with remitted GML, the genera Haemophilus and Moraxella were significantly more abundant than in refractory patients, while Atopobium and Actinomyces were significantly more abundant in refractory patients. Detailed analysis of the gastric microbiota revealed significant changes in the bacterial composition of the gastric mucosa in patients with GML that may have a role in gastric lymphomagenesis but not any new pathobionts.
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📚 EuropePMC5.371 artigos no totalmostrando 199
[Clinical analysis of 49 cases of malignant lymphoma of the head and neck in children].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgeryEvaluation of ovarian functions in girls treated for hematological malignancy.
Scientific reportsFertility preservation counselling and practice among women with lymphomas: a retrospective study.
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and GynaecologyPrimary gastric T-cell lymphoma presenting with perforation: a case report and review of the literature.
Journal of hematopathology[Clinical features and outcomes of digestive tract perforation in pediatric mature B-cell non-Hodgkin lymphoma].
Zhonghua yi xue za zhiGray Zone Lymphoma: The Overlap Between Hodgkin's and Non-Hodgkin's Lymphoma.
Archivos de bronconeumologiaAn Unexpected Lymphoma: A Rare Case of Primary Gastric Burkitt's Lymphoma.
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Transplantation and cellular therapyPrimary gastric diffuse large B-cell lymphoma: A multicentre retrospective study.
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Cancer medicineInhibition of NEK2 Promotes Chemosensitivity and Reduces KSHV-positive Primary Effusion Lymphoma Burden.
Cancer research communicationsMucosa-associated lymphoid tissue lymphoma at the parotid gland.
Journal of cancer research and therapeuticsIncreasing Annual Cancer Incidence in Patients Age 20-49 Years: A Real-Data Study.
JCO global oncology[How I treat relapsed/transformed follicular lymphoma].
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International journal of radiation oncology, biology, physicsCD8+ NKs as a potential biomarker of complete response and survival with lenalidomide plus R-GDP in the R2-GDP-GOTEL trial in recurrent/refractory diffuse large B cell lymphoma.
Frontiers in immunologyAnalysis of cerebrospinal fluid for the diagnosis of CNS lymphoma: Comparison of the ESCCA/ISCCA protocol and real-world data of the CytHem/LOC French network.
Cytometry. Part B, Clinical cytometryClinical features and imaging manifestations for intravascular large B-cell lymphoma.
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciencesThe role of baseline 2-[18 F]-FDG-PET/CT metrics and radiomics features in predicting primary gastric lymphoma diagnosis.
Hematological oncologyWhole-exome sequencing is feasible on a fresh-frozen skin sample of intravascular large B cell lymphoma.
Clinical and experimental medicinePrimary pancreatic lymphoma: Histopathological pattern of 8 cases.
Saudi medical journalTwenty Years of Advancing Discoveries and Treatment of Mantle Cell Lymphoma.
Oncology (Williston Park, N.Y.)Long-term monitoring of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene.
Scientific reportsInflammatory bowel disease is associated with multiple sclerosis or Hodgkin lymphoma.
European journal of gastroenterology & hepatologyPrimary thyroid lymphoma: a case series.
Journal of medical case reportsPhenome-wide Mendelian randomization analysis reveals multiple health comorbidities of coeliac disease.
EBioMedicineUnusual Presence of Synchronous Primary Ovarian and Thyroid Extranodal Non-Hodgkin Lymphoma Without Lymph Node Involvement.
Clinical nuclear medicineCC-96673 (BMS-986358), an affinity-tuned anti-CD47 and CD20 bispecific antibody with fully functional fc, selectively targets and depletes non-Hodgkin's lymphoma.
mAbsChanges in mortality associated with different hematologic malignancies during the pandemic in the United States.
International journal of cancerThe quest for a cure in follicular lymphoma.
BloodCost analysis of patients undergoing allogeneic stem cell transplantation or chimeric antigen receptor T-cell therapy in relapsed or refractory diffuse large B-cell lymphoma from a German healthcare payer perspective.
Bone marrow transplantation[Severe consciousness disturbance after cord blood transplantation for relapsed T lymphoblastic lymphoma].
[Rinsho ketsueki] The Japanese journal of clinical hematologyInfluence of Respiratory Motion on Dose Distribution in Gastric Mucosa-associated Lymphoid Tissue Lymphoma Radiotherapy.
Anticancer research[A Case of Primary Gastric Lymphoma with Spontaneous Perforation].
Gan to kagaku ryoho. Cancer & chemotherapyTafasitamab for the treatment of patients with diffuse large B-cell lymphoma.
Human vaccines & immunotherapeuticsFamilial non-Hodgkin lymphoma with inborn error of immunity due to ORAI1 defect.
Pediatric blood & cancerOut of specification Tisagenlecleucel is associated with outcomes comparable to standard of care product in relapsed or refractory diffuse large B-cell lymphoma.
Bone marrow transplantationUpdate: The molecular spectrum of virus-associated high-grade B-cell non-Hodgkin lymphomas.
Blood reviewsIndolent T-lymphoblastic proliferation involving hepatocellular carcinoma-presentation in novel settings and comprehensive review of literature.
Journal of hematopathologyMyeloid and lymphoid neoplasm with novel complex translocation: unusual case report with T-lymphoblastic lymphoma, myeloid hyperplasia, eosinophilia, basophilia, and t(1;8;10)( (p31;q24;q11.2).
Journal of hematopathologyCurrent development of chimeric antigen receptor T-cell therapy for diffuse large B-cell lymphoma and high-grade B-cell lymphoma.
European journal of haematologyEpstein-Barr virus-associated lymphomas decoded.
British journal of haematology[Non-Hodgkin large B-cell lymphoma of the bile duct mimicking a Klatskin tumor: case report].
Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)Unraveling the enigma of B cells in diffuse large B-cell lymphoma: unveiling cancer stem cell-like B cell subpopulation at single-cell resolution.
Frontiers in immunologyPrimary Canalicular MALT Lymphoma Masquerading as Chronic Canaliculitis.
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Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International ConferenceIntegrating CAR-T cell therapy into the management of DLBCL: what we are learning.
Expert opinion on biological therapyB-cell hepatosplenic lymphoma presenting in adult patient after spontaneous splenic rupture followed by severe persistent hypoglycaemia: type B lactic acidosis and acute liver failure.
BMJ case reports[Analysis of the feasibility and prognostic value of circulating tumor DNA monitoring in detecting gene mutations in patients with diffuse large B-cell lymphoma receiving chimeric antigen receptor T-cell therapy].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiSignificant response of patients with transformed follicular lymphoma with rapid disease progression to CAR-T therapy.
Journal of clinical and experimental hematopathology : JCEHOptical Genome Mapping Reveals Novel Structural Variants in Lymphoblastic Lymphoma.
Journal of pediatric hematology/oncologyClusters, crop dusters, and myth busters: a scoping review of environmental exposures and cutaneous T-cell lymphoma.
Italian journal of dermatology and venereologyIntraspinal non-Hodgkin lymphoma with AIDS.
Asian journal of surgeryLifetime occupational and recreational physical activity and risk of lymphoma subtypes. Results from the European Epilymph case-control study.
Cancer epidemiology[Expression and significance of jumonji domain-containing protein 2B and hypoxia inducible factor-1α in non-Hodgkin lymphoma tissues in children].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsGastric microbiota in patients with gastric MALT lymphoma according to Helicobacter pylori infection.
Clinics and research in hepatology and gastroenterologyCollision Kidney Tumor Consisting of Clear Cell Renal Cell Carcinoma and Primary Renal Mantle Cell Lymphoma: A Case Report.
Archivos espanoles de urologiaA paradox of choice: Sequencing therapy in relapsed/refractory diffuse large B-cell lymphoma.
Blood reviewsDifferentiation of Sinonasal NKT From Diffuse Large B-Cell Lymphoma Using Machine Learning and MRI-Based Radiomics.
Journal of computer assisted tomographyEntirely noninvasive outcome prediction in central nervous system lymphomas using circulating tumor DNA.
BloodHow to integrate CD19 specific chimeric antigen receptor T cells with other CD19 targeting agents in diffuse large B-cell lymphoma?
Hematological oncologyHIV-1 DNA levels in peripheral blood mononuclear cells of patients with HIV-related non-Hodgkin's lymphoma.
Chinese medical journalAn Unusual Case of Extranodal Marginal Zone Lymphoma Mimicking Abdominal Cocoon Syndrome in an Adolescent Patient.
Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society[Current and future perspectives on CAR-T cell therapy to adult malignant lymphoma].
[Rinsho ketsueki] The Japanese journal of clinical hematology[Usefulness of liquid biopsy technology in clinical practice of malignant lymphoma].
[Rinsho ketsueki] The Japanese journal of clinical hematologyMultiple skin lesions, especially on the legs, predict a poorer prognosis in skin lymphoma with large tumour cells.
The British journal of dermatologyTransformation of indolent follicular lymphoma into diffuse large B-cell lymphoma - the molecular basis of "cancer aggressiveness".
Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnostiBlinatumomab consolidation post-autologous stem cell transplantation in patients with diffuse large B-cell lymphoma.
Blood advancesTackling PD1i resistance in Hodgkin lymphoma.
BloodDual PI3K/HDAC Inhibitor BEBT-908 Exhibits Potent Efficacy as Monotherapy for Primary Central Nervous System Lymphoma.
Targeted oncologyGlofitamab monotherapy induces high complete response rates and manageable safety in Chinese patients with heavily pretreated relapsed or refractory diffuse large B-cell lymphoma.
HaematologicaAllogeneic hematopoetic stem cell transplant for patients with refractory T-Cell lymphomas.
European journal of haematologyConditional activation of an anti-IgM antibody-drug conjugate for precise B cell lymphoma targeting.
Frontiers in immunologyBortezomib Is Effective in the Treatment of T Lymphoblastic Leukaemia by Inducing DNA Damage, WEE1 Downregulation, and Mitotic Catastrophe.
International journal of molecular sciencesComparison of MEAM, MCEC and LEED high-dose chemotherapy followed by autologous stem cell transplantation in relapsed/refractory diffuse large B-cell lymphoma: data from the Japan Society for Hematopoietic and Cellular Therapy Registry.
Bone marrow transplantationExpression of "DNA damage response" pathway genes in diffuse large B-cell lymphoma: The potential for exploiting synthetic lethality.
Hematological oncologyUse of PD-1 blockade in refractory/relapsed natural killer T-cell lymphomas: a systematic review and synthesis of case reports.
Leukemia & lymphomaThe utility of CONUT score in indolent lymphoma patients.
Nigerian journal of clinical practiceDuodenal plasmablastic lymphoma in an human immunodeficency virus-negative patient: a case report.
Journal of medical case reportsEosinophilic myocarditis mimicking acute coronary syndrome in a young man with T-lymphoblastic lymphoma and hypereosinophilia.
BMJ case reportsPaediatric B lymphoblastic leukaemia with hyperdiploidy and a false-positive KMT2A fluorescence in situ hybridization result.
Cancer geneticsCARs put age in the rearview mirror.
BloodCost-effectiveness of granulocyte colony-stimulating factors (G-CSFs) for the prevention of febrile neutropenia (FN) in patients with cancer.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in CancerImproved early outcome prediction by MRI-based 3D tumor volume assessment in patients with CNS lymphomas.
Neuro-oncologyRole of non-Helicobacter pylori gastric Helicobacters in helicobacter pylori-negative gastric mucosa-associated lymphoid tissue lymphoma.
World journal of gastroenterologyPET/CT: Clinical role in lymphomas.
Hellenic journal of nuclear medicineAnalysis of genomic alterations in primary central nervous system lymphoma.
MedicineMolecular techniques drive cutting edge advancements in management of cutaneous T cell lymphoma.
Frontiers in immunologyClinicopathological Characteristics and Prognosis of Diffuse Large B-Cell Lymphoma in Relation to CA-125 and CA 19-9 Expression.
Journal of evidence-based integrative medicinePrediction and prognostic potential of NR3C1 gene expression level in DLBCL patients.
Hematology (Amsterdam, Netherlands)Differential survival of Brazilian patients with diffuse large B-cell lymphoma with and without HIV infection.
AIDS (London, England)Elevated interleukin-10 levels in patients with ocular toxoplasmosis.
Parasites, hosts and diseasesDisease site number was not prognostic in a low-risk Hodgkin lymphoma combined modality trial: revisiting PHC HOD90.
Blood advancesLoncastuximab tesirine in relapsed/refractory diffuse large B-cell lymphoma: long-term efficacy and safety from the phase II LOTIS-2 study.
HaematologicaNovel anti-CD30/CD3 bispecific antibodies activate human T cells and mediate potent anti-tumor activity.
Frontiers in immunologyCost-effectiveness analysis of transplant-ineligible relapsed or refractory diffuse large B-cell lymphoma treatment options-Experience of the efficiency frontier approach.
European journal of haematologyA Boy Safely Treated with Tyrosine Kinase Inhibitors for Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia with Osteolysis.
Acta medica OkayamaFollicular lymphoma microenvironment: insights provided by single-cell analysis.
Journal of clinical and experimental hematopathology : JCEHNodular Pulmonary Amyloidosis Preceding Gastric Mucosa-associated Lymphoid Tissue Lymphoma, Initially Suspected to Be Lung Cancer.
The Tokai journal of experimental and clinical medicineThe Burden of Epstein-Barr Virus (EBV) and Its Determinants among Adult HIV-Positive Individuals in Ethiopia.
VirusesSuppression of Autophagy Can Augment PIK3 Inhibitor Induced Apoptosis in T Lymphoblastic Leukemia Cell Lines.
Annals of clinical and laboratory scienceCurrent Treatments in Mantle Cell Lymphoma.
Oncology (Williston Park, N.Y.)Diffuse large B-cell lymphoma presenting as an ileocaecal mass in a post-transplant patient.
BMJ case reportsComparison of tisagenlecleucel with conventional treatments for relapsed/refractory diffuse large B-cell lymphomas: a retrospective external comparator study.
Blood cancer journalPTCL and ICIs: a matter of time and subtype.
BloodAlcohol consumption and cancer incidence in women: interaction with smoking, body mass index and menopausal hormone therapy.
BMC cancerCLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression.
Journal for immunotherapy of cancerA Microenvironment-Related Nine-Gene Signature May Predict Survival in Mycosis Fungoides Patients at Diagnosis.
CellsHelicobacter pylori-negative mucosa-associated lymphoid tissue (MALT) lymphoma of the stomach: A clinicopathologic analysis.
American journal of clinical pathology[The consensus of the diagnosis and treatment of adult T-cell lymphoblastic lymphoma in China (2023)].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiComparative effectiveness of salvage chemotherapy regimens and chimeric antigen T-cell receptor therapies in relapsed and refractory diffuse large B cell lymphoma: a network meta-analysis of clinical trials.
Leukemia & lymphomaUtility of cerebrospinal fluid liquid biopsy in distinguishing CNS lymphoma from cerebrospinal infectious/demyelinating diseases.
Cancer medicineRadiotherapy in the management of rare gastrointestinal cancers: A systematic review.
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologiqueOutcome of Hypofractionated Radiotherapy for Localized Gastric Mucosa-associated Lymphoid Tissue Lymphoma.
Anticancer researchPhase 1 Study of JNJ-64619178, a Protein Arginine Methyltransferase 5 Inhibitor, in Advanced Solid Tumors.
Clinical cancer research : an official journal of the American Association for Cancer ResearchEyewash with balanced salt solution after intravitreal methotrexate injection in a case of vitreoretinal lymphoma: a simple but effective way to prevent ocular surface toxicity.
BMJ case reportsMapping the key characteristics of carcinogens for glyphosate and its formulations: A systematic review.
ChemosphereLymphomas affecting the submandibular glands.
Medicina oral, patologia oral y cirugia bucalCommentary on small-volume biopsy of follicular lymphoma: Practical issues in the molecular era.
Cancer cytopathologyLymphomas of Central Nervous System.
Advances in experimental medicine and biologyCytological spectrum of testicular malignancies with histopathological correlation: A retrospective analysis.
Diagnostic cytopathologyCancer Statistics in Pakistan From 1994 to 2021: Data From Cancer Registry.
JCO clinical cancer informaticsCutaneous B-cell lymphomas: 2023 update on diagnosis, risk-stratification, and management.
American journal of hematologyImplications of Contact Days in the Treatment of Relapsed Refractory Diffuse Large B-Cell Lymphoma.
The oncologistCT radiomics can predict disease progression within 6 months after chimeric antigen receptor-modified T-cell therapy in relapsed/refractory B-cell non-Hodgkin's lymphoma patients.
Clinical radiologyDevelopment of a radiomic-clinical nomogram for prediction of survival in patients with diffuse large B-cell lymphoma treated with chimeric antigen receptor T cells.
Journal of cancer research and clinical oncologyEvaluation of the efficacy of gastric lymphoma treated with non-surgical therapy using oral and double contrast-enhanced gastric ultrasonography.
Medical ultrasonography"The state of the science" of childhood, adolescent and young adult Non Hodgkin Lymphoma (NHL).
Best practice & research. Clinical haematologyFive-year Progress of Gastric MALT Lymphoma Presenting as Gastric Outlet Obstruction.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chiBeEAM (Bendamustine, Etoposide, Cytarabine, Melphalan) Versus BEAM (Carmustine, Etoposide, Cytarabine, Melphalan) as Conditioning Regimen Before Autologous Haematopoietic Cell Transplantation: A Systematic Review and Meta-Analysis.
Cell transplantationCAR T-cell therapy for central nervous system lymphomas: blood and cerebrospinal fluid biology, and outcomes.
HaematologicaLong-term Complete Remission of Decitabine-Primed Tandem CD19/CD22 CAR-T Therapy with PD-1 and BTK Inhibitors Maintenance in a Refractory Primary Central Nervous System Lymphoma Patient.
Cancer research and treatmentElraglusib (formerly 9-ING-41) possesses potent anti-lymphoma properties which cannot be attributed to GSK3 inhibition.
Cell communication and signaling : CCSThe Effect of Surgery on the Prognosis of Gastric Lymphoma: A Meta-analysis.
The American surgeonLP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair.
OncotargetTfl deletion induces extraordinary Cxcl13 secretion and cachexia in VavP-Bcl2 transgenic mice.
Frontiers in immunologyAnalysis of Cancer Research Projects in Sub-Saharan Africa: A Quantitative Perspective on Unmet Needs and Opportunities.
JCO global oncologyImmunochemotherapy for life-threatening haematological malignancies in pregnancy: a systematic review of the literature and cross-sectional analysis of clinical trial eligibility.
The Lancet. HaematologyA Novel Autologous CAR-T Therapy, YTB323, with Preserved T-cell Stemness Shows Enhanced CAR T-cell Efficacy in Preclinical and Early Clinical Development.
Cancer discoveryA new nomogram for assessing complete response (CR) in gastric diffuse large B-cell lymphoma (DLBCL) patients after chemotherapy.
Journal of cancer research and clinical oncologyAssociation between medically diagnosed postnatal infection and childhood cancers: A matched case-control study in Denmark, 1978 to 2016.
International journal of cancerIncreased plasma endostatin and GDF15 in indolent non-Hodgkin lymphoma.
Upsala journal of medical sciencesExperience of Non-Hodgkin's Lymphoma in the Central Nervous System Presented as Neurological Deficit from 2017-2021 in a Medical Center in Mexico City.
Turkish neurosurgery[Ⅳ. Advances in Diagnosis and Treatment of Vitreoretinal Lymphoma].
Gan to kagaku ryoho. Cancer & chemotherapyTesticular Rosai-Dorfman disease clonally related to CMML - Case report and literature review.
Pathology, research and practiceInternational validation of two EORTC questionnaires for assessment of health-related quality of life for patients with high-grade non-Hodgkin lymphoma (QLQ-NHL-HG29) and low-grade non-Hodgkin lymphoma (QLQ-NHL-LG20).
CancerDiffuse large B-cell lymphomas have spatially defined, tumor immune microenvironments revealed by high-parameter imaging.
Blood advancesThe clinicopathological characteristics of gastric cancer and precancerous conditions in gastric DLBCL and MALT lymphoma patients: a multi-center retrospective study.
Annals of medicineSkin swabs in the skin lymphoma clinic: from swab to treatment.
The British journal of dermatologyB-Cell Receptor Signaling Is Thought to Be a Bridge between Primary Sjogren Syndrome and Diffuse Large B-Cell Lymphoma.
International journal of molecular sciencesThinking "outside the germinal center": Re-educating T cells to combat follicular lymphoma.
Blood reviewsFailure of CAR-T cell therapy in relapsed and refractory large cell lymphoma and multiple myeloma: An urgent unmet need.
Blood reviewsHow I approach B-lymphoblastic lymphoma in children.
Pediatric blood & cancerUnusual presentation of a MALT lymphoma.
Acta otorrinolaringologica espanolaHumoral Immunity After COVID-19 Vaccination in Chronic Lymphocytic Leukemia and Other Indolent Lymphomas: A Single-Center Observational Study.
The oncologistEffectiveness of Helicobacter pylori eradication in the treatment of early-stage gastric mucosa-associated lymphoid tissue lymphoma: An up-to-date meta-analysis.
World journal of gastroenterologyPrimary esophageal follicular lymphoma: a rare entity.
Revista espanola de enfermedades digestivasAssociation of KIR Genes Polymorphism and its HLA Ligands in Diffuse Large B-cell Lymphoma.
Clinical lymphoma, myeloma & leukemiaOutcome of Brain Lymphoma in a High Epstein-Barr Virus-Prevalence Country After Kidney Transplantation.
Transplantation proceedingsEnhancing information on stage at diagnosis of cancer in Africa.
Acta oncologica (Stockholm, Sweden)Synchronous gastric MALT lymphoma and gastric adenocarcinoma of fundic gland type arising from a hamartomatous inverted polyp in a Helicobacter pylori naive patient.
Clinical journal of gastroenterologyPrimary breast B-cell non-Hodgkin’s lymphoma of the breast. Case Report and review of the literature.
Revista colombiana de obstetricia y ginecologiaRecapitulated Late-Onset Inflammatory Toxicities and Progressive Dysautonomia with Persistence of Central Memory CD4+ Chimeric Antigen Receptor T Cells in a Case of Transformed Follicular Lymphoma: Case Report.
Acta haematologicaSafety and efficacy of tisagenlecleucel in patients with relapsed or refractory B-cell lymphoma: the first real-world evidence in Japan.
International journal of clinical oncologyPATTERN OF A PRIMARY B-CELL LYMPHOMA IN ULNAR NERVE: INTRANEURAL OR EXTRANEURAL.
Georgian medical newsClinical and laboratory diversity of diffuse large B-cell lymphomas in children with Nijmegen breakage syndrome.
HaematologicaHX009, a novel BsAb dual targeting PD1 x CD47, demonstrates potent anti-lymphoma activity in preclinical models.
Scientific reportsCAR T-Cell therapy for the management of mantle cell lymphoma.
Molecular cancer[MIC2 (CD99) as a diagnostic marker for TdT-negative B lymphoblastic lymphoma].
[Rinsho ketsueki] The Japanese journal of clinical hematologyOccult optic nerve neurolymphomatosis of T-lymphoblastic lymphoma detected by PET/MRI.
British journal of haematologyPrognostic value of cross-lineage expression of the myeloid-associated antigens CD13 and CD33 in adult B-lymphoblastic leukemia: A large real-world study of 1005 patients.
Cancer medicineFactors associated with survival in patients with lymphoma and HIV.
AIDS (London, England)Clinical features predictive of vision loss in patients with vitreoretinal lymphoma: a single tertiary center experience.
Scientific reportsEarly gastric mucosa-associated lymphoid tissue lymphoma treated by endoscopic submucosal dissection.
EndoscopyLow-grade follicular lymphoma with extensive marginal zone differentiation and expression of MUM1 and CD30.
BloodExosomal PD‑L1 promotes the formation of an immunosuppressive microenvironment in gastric diffuse large B‑cell lymphoma.
Oncology reportsEpidemiological Features and Outcomes of HTLV-1 Carriers Diagnosed With Cancer: A Retrospective Cohort Study in an Endemic Country.
JCO global oncologyDiagnosis and management of lymphoblastic lymphoma in children, adolescents and young adults.
Best practice & research. Clinical haematologyA phase II study to evaluate the efficacy of low-dose rasburicase (1.5mg) in adolescent and adult acute leukemia and high-grade lymphomas with tumor lysis syndrome.
Leukemia & lymphomaBone marrow microenvironment disruption and sustained inflammation with prolonged haematologic toxicity after CAR T-cell therapy.
British journal of haematologyThe outcome of ibrutinib-based regimens in relapsed/refractory central nervous system lymphoma and the potential impact of genomic variants.
Advances in clinical and experimental medicine : official organ Wroclaw Medical UniversityRole and mechanism of PIM family in the immune microenvironment of diffuse large B cell lymphoma.
World journal of surgical oncologyAtypical MYC rearrangement pattern of 3' deletion and 5' amplification along with independent IGH rearrangement: A case study.
Indian journal of cancerImproving outcomes of childhood and young adult non-Hodgkin lymphoma: 25 years of research and collaboration within the framework of the European Intergroup for Childhood Non-Hodgkin Lymphoma.
The Lancet. HaematologyThe Outcomes of Diffuse Large B-cell Lymphoma Patients with Synchronous and Early Central Nervous System Involvement: A Single-Center Experience.
Asian Pacific journal of cancer prevention : APJCPFactors associated with long-term functional and psychosocial outcomes in patients with non-Hodgkin lymphoma.
Journal of rehabilitation medicineBreast implant-induced cutaneous lymphoma.
International journal of dermatologyLong-term clinical outcomes of gastric mucosa-associated lymphoid tissue lymphoma in real-world experience.
Annals of hematologyDiffuse large B cell lymphoma CD5-positive arising in an immune deficiency and immune dysregulation setting: A case report and brief review of the literature.
Medicine[SENTIERI - Epidemiological Study of Residents in National Priority Contaminated Sites. Sixth Report].
Epidemiologia e prevenzioneNomograms for predicting overall survival and cancer-specific survival in patients with head and neck non-Hodgkin lymphoma: A population-based study.
MedicineB-mode ultrasound and colour Doppler findings in cats with gastric lymphoma.
Journal of feline medicine and surgery[Cardiovascular risk evaluation in the treatment of Hodgkin lymphoma-are we on the road to individualized planning?].
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]Efficacy of chimeric antigen receptor T cell therapy and autologous stem cell transplant in relapsed or refractory diffuse large B-cell lymphoma: A systematic review.
Frontiers in immunologyAssociações
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Doença com base genética
Um médico geneticista pode ajudar no diagnóstico de Linfoma maligno não-Hodgkin e no aconselhamento genético da família.
Doenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Perguntas frequentes
O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu
É uma neoplasia das células do sistema linfático, como linfócitos B, T ou NK, caracterizada pela ausência de células de Reed-Sternberg. Pode acometer pessoas de diferentes faixas etárias, desde a infância até a terceira idade.
Referências
Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete
10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Citar este verbete
Raras. (s.d.). Linfoma maligno não-Hodgkin. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/linfoma-maligno-nao-hodgkin
Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
Linfoma maligno não-Hodgkin
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- Doença rara (ontologia)
- fonte: Orphanet
- Identificador unificado
- fonte: MONDO
- Codificação WHO/SUS
- fonte: WHO ICD-10 / DATASUS
- Indexação biomédica
- fonte: MeSH (NLM)
- Dado público estruturado
- fonte: Wikidata
- Medicamentos aprovados FDA
- fonte: FDA OpenFDA
- Reposicionamento
- fonte: Drug Repurposing Hub
