Linfomas cutâneos de células T (LCCT) ou Linfoma T cutâneo são um grupo de cânceres originados de linfócitos T que formam erupções ou placas vermelhas na pele, similares a uma dermatite crônica, antes de se espalhar pelos outros órgãos. São linfomas não Hodgkin, geralmente indolentes, difíceis de curar, mas geralmente pouco agressivos e tratáveis.
Introdução
O que você precisa saber de cara
Linfoma cutâneo de células T é um grupo de linfomas não-Hodgkin que se manifestam primariamente na pele, apresentando-se como pápulas ou placas eritematosas. Pode estar associado a sintomas sistêmicos como calafrios, hepatoesplenomegalia e hipercalcemia.
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<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 19 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 54 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
6 genes identificados com associação a esta condição.
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates T
Cell membraneCell junction
Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity
Cell membraneSecreted
Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells (PubMed:24665965). Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in bo
Cell membraneCell surface
Immunodeficiency 123 with HPV-related verrucosis
An autosomal recessive immunologic disorder characterized by susceptibility to human papilloma virus (HPV) infections and the development of HPV-related common verrucosis in the first decade of life. In some patients with HPV2 infection, warts may progress to severe generalized hyperkeratotic cutaneous papillomatosis with cutaneous horns ('tree-man' phenotype). In patients with HPV4 infection, warts remains stable and may even regress with age.
Inhibitory receptor acting as a major negative regulator of T-cell responses (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:18641304, PubMed:28484017). Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:28484017)
Cell membrane
Systemic lupus erythematosus
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stran
Nucleus, nucleolusNucleus, nucleoplasmCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including
Immunodeficiency 35
A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
Medicamentos e terapias
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: C-C chemokine receptor type 4 cross-linking agent
Mecanismo: Dihydrofolate reductase inhibitor
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Retinoid X receptor agonist
Mecanismo: Tubulin inhibitor
Mecanismo: Opioid receptors; mu/kappa/delta antagonist
Mecanismo: T-cell surface antigen CD4 other
Variantes genéticas (ClinVar)
88 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
31 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Linfoma cutâneo de células T
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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Outros ensaios clínicos
Publicações mais relevantes
T-cell receptor gamma (TRG) diversity predicts peripheral blood involvement in primary cutaneous T-cell lymphoma.
Localized palmar mycosis fungoides: A case report.
Mycosis fungoides (MF) is the most common primary cutaneous T-cell lymphoma, yet palmar MF is extremely rare and easily mistaken for chronic dermatoses such as psoriasis. Delayed recognition can lead to inappropriate treatment and worse outcomes. This case demonstrates how careful histopathology and immunohistochemistry can provide critical diagnostic clarity in atypical presentations. A 63-year-old woman presented with an 8-year history of erythema, dryness, scaling, and fissuring on both palms. The lesions had been misdiagnosed as psoriasis and showed no response to long-term topical calcipotriol. Histopathology of a palm biopsy revealed epidermotropism of atypical lymphocytes with cerebriform nuclei and Pautrier microabscesses. Immunohistochemistry demonstrated positivity for CD2, CD3, CD4, and CD45RO with immunophenotypic variation, confirming palmar MF. The patient was staged as early MF (IA-IB). Systemic therapy with intramuscular interferon α-2b, oral methylprednisolone, and acitretin was initiated due to chronicity, bilateral palm involvement, and resistance to topical therapy. Significant improvement was noted after 2 months. At the 1-year follow-up, her palms showed complete clearance of lesions with sustained remission. This case highlights the diagnostic pitfalls of palmar MF and underscores the necessity of early biopsy in patients with persistent, treatment-resistant palm dermatoses. Raising clinical awareness of this rare entity may prevent misdiagnosis, facilitate timely therapy, and ultimately improve patient prognosis.
Radiotherapy dose-response of mycosis fungoides with large cell transformation.
Mycosis fungoides (MF) is the most prevalent subtype of primary cutaneous T-cell lymphoma. Large cell transformation of MF (LCTMF) is rare and confers a poor prognosis. Radiotherapy (RT) is an effective local treatment for LCTMF; however, dose-response data are limited. Eligibility for this retrospective study required biopsy-proven LCTMF with clinico-pathological correlation, diagnosed 1/1/1990-1/10/2021, and managed at Peter MacCallum Cancer Centre. 83 patients were eligible. Median age was 68 years, 63 (76 %) patients had cutaneous-only LCTMF at time of diagnosis. Median follow-up was 8.0 (95 % CI: 6-11) years. Details of 155 irradiated LCTMF lesions (from 49 patients) were available: 150 cutaneous, 5 extra-cutaneous. For cutaneous LCTMF, median equivalent dose in 2.0 Gy per fraction (EQD2, α/β of 10) was 30.6 (range, 4.7-46.3) Gy. Dose-response data were available for 141 cutaneous LCTMF lesions. Overall response rate (ORR) was 94 % (60 % complete response (CR), 35 % partial response). For cutaneous lesions treated with >12.0 Gy, ORR was 100 %. Increasing doses of RT were associated with greater CR rates: doses >36.0 Gy achieved 100 % CR rate. 22 (27 %) patients had unifocal cutaneous-only LCTMF and were treated with local RT-alone, median EQD2 36.0 Gy (range, 17.3-46.3 Gy). CR rate was 100 %. 9 (41 %) patients remained relapse-free (median follow-up, 3.2 years). Only 1 patient experienced infield-only recurrence at first relapse. LCTMF is radio-responsive, with EQD2 >12.0 Gy associated with 100 % ORR. Dose-response was observed, with EQD2 >36.0 Gy achieving 100 % CR rate. For unifocal cutaneous LCTMF, RT-alone achieved excellent infield control with possible curative potential in a proportion of patients.
Histopathologic Spectrum of Primary Cutaneous T-Cell Lymphomas: Insights From a Vietnamese Case Series.
Primary cutaneous T-cell lymphomas (PCTCLs) are a rare and heterogeneous group of extranodal non-Hodgkin lymphomas originating from skin-homing T cells. Most current knowledge about PCTCLs is derived from Western populations, with limited data available from Southeast Asia, including Vietnam. To characterize the clinical, histopathologic, and immunohistochemical features of PCTCLs in a cohort of Vietnamese patients. A retrospective case series was conducted involving 39 PCTCL cases. Demographic and clinical data were collected from medical records and archived clinical images. Histopathologic and immunohistochemical evaluations were independently performed by 3 pathologists, following the fifth edition of the WHO Classification of Haematolymphoid Tumours. Subcutaneous panniculitis-like T-cell lymphoma was most frequent (36%), followed by mycosis fungoides (MF, 28%) and primary cutaneous anaplastic large cell lymphoma (pcALCL, 15%). Subcutaneous panniculitis-like T-cell lymphoma predominantly affected young women, whereas MF and pcALCL occurred in older adults (median age, 64 years). Beyond canonical clinicopathologic features, notable findings included high rates of Pautrier microabscesses and eosinophilic infiltration in MF (each 73%), 1 ulcerated MF case, and 1 pcALCL with a CD4-/CD8- phenotype. Although clinicopathologic features largely aligned with established diagnostic criteria, several differences from international series were observed. These disparities likely reflect delayed diagnosis, referral bias toward more severe disease, and broader systemic and cultural factors in Vietnam, and constrained availability of advanced diagnostic assays, underscoring the need to strengthen clinicopathologic integration and expand access to specialized care.
Bacterial skin colonization and systemic antibiotic treatment in patients with cutaneous T-cell lymphoma.
Bacterial colonization, particularly by Staphylococcus aureus (SA), is prevalent on the skin of patients with primary cutaneous T-cell lymphoma (CTCL). This study aimed to investigate risk factors for cutaneous bacterial and Staphylococcus aureus colonization and to evaluate their impact, together with systemic antibiotic use, on the prognosis of patients with CTCL. This retrospective study included 113 CTCL patients who underwent skin swab testing at Peking University First Hospital from 2010 to 2024. Eighty-five patients (75.2%) tested positive for bacterial skin colonization (SA, 60.2%). Ulcerated lesions significantly increased the likelihood of a positive result in bacterial/SA skin cultures (multivariate analysis). Additionally, advanced stages, the presence of tumors, erythroderma, lymphopenia, and eosinophilia were associated with an increased risk of positive skin cultures (Univariate analysis). Cox regression analysis indicated that skin bacterial/SA colonization and antibiotic intervention, were not correlated with overall survival (p > 0.05). This retrospective study presents data on the prevalence of bacterial skin colonization in Asian CTCL patients. Ulcerated lesions emerged as the most significant risk factor associated with cutaneous bacterial/SA colonization. In Asian patients with CTCL, neither bacterial or Staphylococcus aureus skin colonization was associated with a poorer prognosis, nor did short-term systemic antibiotic therapy improve outcomes.
Publicações recentes
Moderate-Dose Local Radiotherapy in Symptomatic CD30-Positive, Anaplastic Lymphoma Kinase (ALK)-Negative Primary Cutaneous T-cell Lymphoma.
Hypopigmented CD8+ Mycosis Fungoides in Sri Lanka: Clinicopathologic Evidence for an Indolent Variant.
Results from a Pilot Study of HyBryte™ (Topical Synthetic Hypericin) Versus Valchlor(®) (Mechlorethamine) in the Treatment of CTCL.
Molecular Markers Distinguishing Early-Stage Mycosis Fungoides From Atopic Dermatitis Skin Lesions.
T-cell receptor gamma (TRG) diversity predicts peripheral blood involvement in primary cutaneous T-cell lymphoma.
📚 EuropePMC96 artigos no totalmostrando 182
T-cell receptor gamma (TRG) diversity predicts peripheral blood involvement in primary cutaneous T-cell lymphoma.
Blood neoplasiaEfficacy and tolerability of mogamulizumab in mycosis fungoides and Sézary Syndrome: a monocentric retrospective study.
Frontiers in oncologyCutaneous and Systemic Complications in Primary CD8+ Aggressive Epidermotropic Cytotoxic T-cell Lymphoma.
CureusLocalized palmar mycosis fungoides: A case report.
MedicineUnusual Presentation of Subcutaneous Panniculitis-Like T-Cell Lymphoma.
Clinical case reportsRadiotherapy dose-response of mycosis fungoides with large cell transformation.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and OncologyClinical presentation and survival outcomes of primary cutaneous T-cell lymphoma among disaggregated Asian American, Native Hawaiian, and Pacific Islander populations.
Journal of the American Academy of DermatologyHistopathologic Spectrum of Primary Cutaneous T-Cell Lymphomas: Insights From a Vietnamese Case Series.
The American Journal of dermatopathologyBacterial skin colonization and systemic antibiotic treatment in patients with cutaneous T-cell lymphoma.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGSynergistic Efficacy of Chidamide and LB100 in Sézary Syndrome via TNC Downregulation and PI3K/AKT/mTOR Dephosphorylation.
Cancer scienceGATA3 as a Prognostic Marker in Early-Stage Classical Mycosis Fungoides: Association With Disease Progression and Survival Outcomes.
Cancer medicineRadiation Therapy Utilization for Primary Cutaneous T-Cell Lymphoma Is Lowest Among Patients Living in the Most Geographically Accessible Areas: An Australian Study.
International journal of radiation oncology, biology, physicsComprehensive characterization of nodal peripheral T-cell lymphoma, not otherwise specified: A report of the 2023 SH/EA4HP lymphoma workshop.
American journal of clinical pathologyCare and treatment for primary cutaneous lymphoma-associated ulcers: Two case reports.
SAGE open medical case reportsEvaluating mogamulizumab in the treatment of primary cutaneous T-cell lymphoma.
ImmunotherapySubcutaneous Panniculitis-Like T-Cell Lymphoma With Increased γδ T Cells: A Potential Diagnostic Pitfall.
The American Journal of dermatopathologyTransient Leukemia in an Adult Dog With Cutaneous T-Cell Lymphoma.
Veterinary clinical pathologyAlopecia Mimicking Lichen Planopilaris in a Patient with Mycosis Fungoides.
Skin appendage disordersPrimary Cutaneous Gamma-Delta T-Cell Lymphoma Presenting With Hemophagocytic Lymphohistiocytosis in a Young Polynesian Male.
Case reports in hematologyDiagnostic Challenges of Early Mycosis Fungoides in Skin of Color: A Case Report and Review.
CureusZNF460 enhances HADHB level by activating its transcription to promote the progression and pulmonary invasion of cutaneous T cell lymphoma.
Archives of biochemistry and biophysicsMusculoskeletal Lymphoma: Imaging Features, Diagnosis, and Assessment of Treatment Response.
Radiographics : a review publication of the Radiological Society of North America, IncRare case of CD20-positive primary cutaneous T-cell lymphoma, NOS, with an aggressive clinical course.
Journal of clinical pathologySuccessfully maintained complete remission of mycosis fungoides by umbilical cord blood transplantation: a case report and literature review.
Dermatology reportsClinical Characteristics, Management and Long-Term Outcomes of 180 Patients With Early-Stage Mycosis Fungoides at a Tertiary Centre-A 34-Year Retrospective Study.
The Australasian journal of dermatology"Missed" Diagnosis of Mycosis Fungoides: A Case Report.
Clinical case reportsCD4/CD8 double-negative mycosis fungoides: a review.
Dermatology reportsClinical characterization of mycosis fungoides with abnormal light reactions induced by narrow-band UVB therapy: A review of a single-center experience.
The Journal of dermatologyA Rare Coexistence of Turner Syndrome and Mycosis Fungoides: A Case Report.
Journal of clinical research in pediatric endocrinologyTreatment of Calcinosis in Dermatomyositis-Case Report and Review.
Journal of clinical medicinePrimary cutaneous T-cell lymphoma not otherwise specified reveals a novel RAB27A variant in Griscelli syndrome type 2.
The British journal of dermatologySkin-directed radiotherapy for primary cutaneous T-cell lymphomas.
Radiation oncology journalWhen mycosis fungoides seems not to be within the spectrum of clinical and histopathological differential diagnoses.
Dermatology reportsAtypical Cutaneous Manifestation of Mycosis Fungoides: A Case Report.
CureusNavigating Diagnostic and Therapeutic Challenges in Primary Cutaneous Gamma/Delta T-Cell Lymphoma: A Case Study of Fatal Outcomes Within Two Months.
The American Journal of dermatopathologyThe fifth edition of the WHO-Classification - what is new for cutaneous lymphomas?
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGCutaneous Lymphoma in a Tertiary Skin Hospital and Referral Centre in Nepal.
Journal of Nepal Health Research CouncilCharacterization of cells and mediators associated with pruritus in primary cutaneous T-cell lymphomas.
Clinical and experimental medicinePrimary cutaneous EBV+ extranodal NK/T-cell lymphoma of gamma/delta T-cell lineage in the posttransplantation setting.
Journal of cutaneous pathologySézary Syndrome in West Sweden: Exploring Epidemiology, Clinical Features, and Treatment Patterns in a Registry-Based Retrospective Analysis.
CancersPhase I/II clinical trial of brentuximab vedotin for pretreated Japanese patients with CD30-positive cutaneous T-cell lymphoma.
The Journal of dermatologyEstimation of the tissue and serum levels of IL-35 in Mycosis fungoides: a case-control study.
Archives of dermatological researchNull T-cell phenotype mycosis fungoides with aberrant CD20 and CD56 expression: A diagnostic dilemma.
Journal of cutaneous pathologyFolliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review.
Clinical case reportsGenomic profiling of mycosis fungoides identifies patients at high risk of disease progression.
Blood advancesA Case Report of Mycosis Fungoides Presenting With Blister Formation.
CureusEvaluation of mortality, prognostic parameters, and treatment efficacy in mycosis fungoides.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGPneumocystis jirovecii Pneumonia in a Patient With Localized Mycosis Fungoides Not Receiving Immunosuppressive Treatment.
CureusDermatology in black skin.
Anais brasileiros de dermatologiaErythrodermic mycosis fungoides: A case report.
World journal of clinical casesHealth-related quality of life and its influencing factors in patients with primary cutaneous B-cell lymphomas: A multicentric study in 100 patients.
Journal of the European Academy of Dermatology and Venereology : JEADVCutaneous T-Cell Lymphoma (CTCL) Arising Post Kidney Transplant: A Review of Clinical Variants in the Literature.
Hematology reportsA Rare and Isolated Presentation of Primary Cutaneous Anaplastic Large Cell Lymphoma on the Breast.
CureusUpdates in pathobiological aspects of anaplastic large cell lymphoma.
Frontiers in oncologyPrimary cutaneous T-cell lymphoma: a review of the most common entities with focus on recent updates.
Human pathologyIncreased risk of sepsis-caused death in Black patients with primary cutaneous T-cell lymphoma and Burkitt lymphoma: A population study of the US SEER registry.
Journal of the American Academy of DermatologyInteresting Presentation of Mycosis Fungoides in Staging on F-18 FDG PET/CT.
Nuclear medicine and molecular imagingmAb14, a Monoclonal Antibody against Cell Surface PCNA: A Potential Tool for Sezary Syndrome Diagnosis and Targeted Immunotherapy.
CancersAn update on mechanisms of pruritus and their potential treatment in primary cutaneous T-cell lymphoma.
Clinical and experimental medicineHyperpigmented Mycosis Fungoides Masquerading as Longstanding Lichen Planus Pigmentosus: A Diagnostic Pitfall.
The American Journal of dermatopathologyIs Cutaneous T-Cell Lymphoma Caused by Ultraviolet Radiation? A Comparison of UV Mutational Signatures in Malignant Melanoma and Mycosis Fungoides.
CellsCutaneous T-cell lymphoma developing in surgical scars post cardiac surgery: A case study.
SAGE open medical case reportsMultidisciplinary Approach to the Diagnosis and Therapy of Mycosis Fungoides.
Healthcare (Basel, Switzerland)Concurrent Presentation of Mycosis Fungoides and Primary Cutaneous Marginal Zone LPD: Clinicopathological Study of 4 Cases and Literature Review.
The American Journal of dermatopathologyThirty Years of Experience With Ocular Adnexal T-Cell Lymphoma.
Ophthalmic plastic and reconstructive surgeryPrimary Cutaneous Peripheral T-Cell Lymphoma With Follicular Helper T-Cell Phenotype: Report of 2 Epstein-Barr Virus-Positive Cases.
The American Journal of dermatopathologyRapidly progressive tumor stage mycosis fungoides: A case report from Syria.
Annals of medicine and surgery (2012)Real-Life Barriers to Diagnosis of Early Mycosis Fungoides: An International Expert Panel Discussion.
American journal of clinical dermatologyDiagnostic Outcomes and Treatment Modalities in Patients with Mycosis Fungoides in West Sweden-A Retrospective Register-Based Study.
CancersFolliculotropic Mycosis Fungoides: Current Guidance and Experience from Clinical Practice.
Clinical, cosmetic and investigational dermatologyDrug library screening identifies histone deacetylase inhibition as a novel therapeutic strategy for choriocarcinoma.
Cancer medicine[New treatment concepts and combination therapies for cutaneous T-cell lymphomas].
Dermatologie (Heidelberg, Germany)Incidence Trends of Primary Cutaneous T-Cell Lymphoma in the US From 2000 to 2018: A SEER Population Data Analysis.
JAMA oncologyCharacterization of primary cutaneous T-cell lymphoma following solid organ transplantation.
International journal of dermatologyNew developments in skin-directed treatments of cutaneous T-cell lymphoma.
Presse medicale (Paris, France : 1983)Continuous low-dose gemcitabine in primary cutaneous T cell lymphoma: A retrospective study.
Dermatologic therapyCD38 Expression by Circulating and Skin-Infiltrating Lymphocytes from Sezary Syndrome Patients: A Flow Cytometry and Immunohistochemistry Study.
Disease markersA Case Report of Double Positive Peripheral T Cell Lymphoma‑ Not Otherwise Specified in A Young Pregnant Female.
Indian dermatology online journalNivolumab in two cases of refractory mycosis fungoides erythroderma.
Central-European journal of immunologyCase Report: Graft Versus Tumor Effect After Non-Myeloablative Allogeneic Stem-Cell Transplantation in a Patient With Brentuximab-Vedotin Refractory Sezary Syndrome.
Frontiers in oncologyCutaneous T-cell lymphoma mimicking myopathy with lipoatrophy.
Neuromuscular disorders : NMDPrimary cutaneous gamma/delta T-cell lymphoma in Taiwan: A series of six cases with frequent solitary presentation and relatively indolent behavior.
Journal of cutaneous pathologyA Comprehensive Update of the Atypical, Rare and Mimicking Presentations of Mycosis Fungoides.
Dermatology and therapySingle-cell RNA sequencing reveals markers of disease progression in primary cutaneous T-cell lymphoma.
Molecular cancerRisk of Non-Hodgkin's Lymphoma in HCV Patients in the United States Between 2013 and 2020: A Population-Based Study.
Clinical lymphoma, myeloma & leukemiaEvaluation of Melanocyte Loss in Mycosis Fungoides Using SOX10 Immunohistochemistry.
Dermatopathology (Basel, Switzerland)DUSP22 rearrangement in primary cutaneous T cell lymphoma with features intermediate between mycosis fungoides, anaplastic large-cell lymphoma and lymphomatoid papulosis.
HistopathologyIndolent CD8+ primary cutaneous T-cell lymphoma involving the eyelid of an adolescent.
Journal of cutaneous pathologyAn expert consensus report on mycosis fungoides in Italy: epidemiological impact and diagnostic-therapeutic pathway.
Italian journal of dermatology and venereologyChlormethine Gel for the Treatment of Skin Lesions in All Stages of Mycosis Fungoides Cutaneous T-Cell Lymphoma: A Narrative Review and International Experience.
Dermatology and therapySingle-Cell RNA Sequencing Reveals Tissue Compartment-Specific Plasticity of Mycosis Fungoides Tumor Cells.
Frontiers in immunologyNormal and cancer fibroblasts differentially regulate TWIST1, TOX and cytokine gene expression in cutaneous T-cell lymphoma.
BMC cancerImmunophenotypic switch in cutaneous T-cell lymphoma: A series of three cases and review of the literature.
Journal of cutaneous pathologyMycosis fungoides of the vulva.
Northern clinics of IstanbulMycosis Fungoides with Dermal Mucin Deposition: An Unusual Variant of the Most Challenging Primary Cutaneous Lymphoma.
Case reports in dermatologyPrognostic factors of patients with mycosis fungoides.
Postepy dermatologii i alergologiiProtein and mRNA Expression Levels of Interleukin-17A, -17F and -22 in Blood and Skin Samples of Patients with Mycosis Fungoides.
Acta dermato-venereologicaT cell lymphoma in the setting of Sjögren's syndrome: T cells gone bad? Report of five cases from a single centre cohort.
Clinical and experimental rheumatologyComparison between the histopathological and immunophenotypical features of hypopigmented and nonhypopigmented mycosis fungoides: A retrospective study.
Journal of cutaneous pathologyClinical Remission in a 72-Year-Old Patient with a Massive Primary Cutaneous Peripheral T-Cell Lymphoma-NOS of the Eyelid, Following Combination Chemotherapy with Etoposide Plus COP.
Diagnostics (Basel, Switzerland)Long-Term Disease Control After Allogeneic Hematopoietic Stem Cell Transplantation in Primary Cutaneous T-Cell Lymphoma; Results From a Single Institution Analysis.
Frontiers in medicinePathogenesis and Therapy of Primary Cutaneous T-Cell Lymphoma: Collegium Internationale Allergologicum (CIA) Update 2020.
International archives of allergy and immunologyAggressive CD4/CD8 Double-Negative Primary Cutaneous T-Cell Lymphoma With Dural Invasion: A Rare Presentation of Mycosis Fungoides?
The American Journal of dermatopathologyTotal skin electron beam therapy for primary cutaneous T-cell lymphomas: clinical characteristics and outcomes in a Mexican reference center.
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyVorinostat upregulates MICA via the PI3K/Akt pathway to enhance the ability of natural killer cells to kill tumor cells.
European journal of pharmacologyMycosis Fungoides, Lymphomatoid Papulosis and Hodgkin's Lymphoma in the Same Patient: Apropos of a Possible Monoclonal Origin.
Indian journal of dermatology[LINEAR MYCOSIS FUNGOIDES IN A BLASCHKOID DISTRIBUTION].
HarefuahPrevalence and spectrum of T-cell lymphoproliferative disorders in patients with Hypereosinophilia: A reference laboratory experience.
Annals of diagnostic pathologyHigh-throughput Sequencing of Subcutaneous Panniculitis-like T-Cell Lymphoma Reveals Candidate Pathogenic Mutations.
Applied immunohistochemistry & molecular morphology : AIMMTwo Different Extranodal Lymphomas in an HIV+ Patient: A Case Report and Review of the Literature.
Case reports in hematologyPrimary Cutaneous Peripheral T-Cell Lymphoma of the Hand: Case Report of a Rare Diagnosis and Review of the Literature.
Journal of hand and microsurgeryT-Cell-Rich Recurrence of Primary Cutaneous Follicle Center Lymphoma After Systemic Rituximab: A Diagnostic Pitfall.
The American Journal of dermatopathologyMycosis Fungoides: A 10-year Turkish Experience.
Acta dermatovenerologica Croatica : ADCFrequent and Persistent PLCG1 Mutations in Sézary Cells Directly Enhance PLCγ1 Activity and Stimulate NFκB, AP-1, and NFAT Signaling.
The Journal of investigative dermatologyIPH4102, a first-in-class anti-KIR3DL2 monoclonal antibody, in patients with relapsed or refractory cutaneous T-cell lymphoma: an international, first-in-human, open-label, phase 1 trial.
The Lancet. OncologyTwo cases of phenotypic switch of primary cutaneous T cell lymphoma after treatment with an aggressive course and review of the literature.
Virchows Archiv : an international journal of pathologyEffective remission of chidamide on treatment of advanced mycosis fungoides: An unusual case report.
Dermatologic therapyPrimary cutaneous CD8+ and CD30+ T-cell lymphoproliferative disorders: case reports and clinical implications.
European journal of dermatology : EJDInterferon alfa-2a maintenance after salvage autologous stem cell transplantation in atypical mycosis fungoides with central nervous system involvement.
The British journal of dermatologySézary Syndrome, recent biomarkers and new drugs.
Chinese clinical oncologyPrimary cutaneous peripheral T-cell lymphoma with a late relapse solely in the ileum mimicking monomorphic epitheliotropic intestinal T-cell lymphoma.
Pathology, research and practiceSézary Syndrome Presenting With Renal Involvement.
American journal of kidney diseases : the official journal of the National Kidney FoundationMethotrexate in the treatment of mycosis fungoides - a multicenter observational study in 79 patients.
European review for medical and pharmacological sciencesMolecular pathogenesis of cutaneous lymphomas.
Experimental dermatologyTotal Skin Electron Beam Therapy with Rotary Dual Technique as Palliative Treatment for Mycosis Fungoides.
In vivo (Athens, Greece)Allogeneic hematopoietic stem cell transplantation in Primary Cutaneous T Cell Lymphoma.
Annals of hematologySurvival outcomes of primary cutaneous T-cell lymphoma in HIV-infected patients: a national population-based study.
Journal of investigative medicine : the official publication of the American Federation for Clinical ResearchSynchronous Occurrence of Mycosis Fungoides, Diffuse Large B Cell Lymphoma and Acute Myeloid Leukemia.
Internal medicine (Tokyo, Japan)Nodal Involvement by CD30+ Cutaneous Lymphoproliferative Disorders and Its Challenging Differentiation From Classical Hodgkin Lymphoma.
Archives of pathology & laboratory medicinePrimary cutaneous T-cell lymphoma: experience from the Peruvian National Cancer Institute.
Anais brasileiros de dermatologiaEruption of lymphocyte recovery with atypical lymphocytes mimicking a primary cutaneous T-cell lymphoma: a series of 12 patients.
Human pathologyA rare localised nasal CD30+ primary cutaneous T-cell lymphoma following liver transplantation.
BMJ case reportsMonitoring the extracorporeal photopheresis by immunophenotyping in a Sézary syndrome patient.
Porto biomedical journalSecond primary cutaneous T-cell lymphoma in patients with non-Hodgkin lymphoma: a chicken-or-the-egg issue.
International journal of dermatologyHistone deacetylase inhibitors downregulate CCR4 expression and decrease mogamulizumab efficacy in CCR4-positive mature T-cell lymphomas.
HaematologicaImmunohistopathological Study of c-FLIP Protein in Mycosis Fungoides.
Asian Pacific journal of cancer prevention : APJCPBrentuximab vedotin therapy for CD30-positive cutaneous T-cell lymphoma: a targeted approach to management.
Future oncology (London, England)Immunohistochemistry reveals an increased proportion of MYC-positive cells in subcutaneous panniculitis-like T-cell lymphoma compared with lupus panniculitis.
Journal of cutaneous pathology[Role of stem cell transplantation in treatment of primary cutaneous T‑cell lymphoma].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte GebieteLow-dose total skin electron beam therapy for cutaneous lymphoma : Minimal risk of acute toxicities.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]Total Skin Electron Beam Therapy as Part of Multimodal Treatment Strategies for Primary Cutaneous T-Cell Lymphoma.
Oncology research and treatmentCD4-Positive T-Cell Large Granular Lymphocytosis Mimicking Sezary Syndrome in a Patient With Mycosis Fungoides.
Cancer control : journal of the Moffitt Cancer CenterManagement Strategies for Mycosis Fungoides in India.
Indian journal of dermatologyMycosis Fungoides: Experience in a Pediatric Hospital.
Actas dermo-sifiliograficasPrimary Cutaneous T Cell Lymphoma (Gamma Delta subtype).
The Medical journal of MalaysiaClinicopathologic Variants of Mycosis Fungoides.
Actas dermo-sifiliograficasPrimary Cutaneous T-cell Lymphoma with Aberrant Expression of CD20.
Acta dermato-venereologicaAlemtuzumab in refractory Sézary syndrome.
Anais brasileiros de dermatologiaFatal Case of Primary Cutaneous Aggressive T-Cell Lymphoma Switching From a CD4+ to a CD8+ Phenotype: Progressive Disease With Bexarotene and Romidepsin Treatment.
The American Journal of dermatopathologyMycosis fungoides patient accompanied actinic keratosis, actinic keratosis with squamous cell carcinoma transformation, and porokeratosis after NBUVB therapy - 1st case report and review of the literature.
MedicineCD8-positive Mycosis Fungoides Masquerading as Pyoderma Gangrenosum.
Indian journal of dermatologyExpression of CD31 in Mycosis Fungoides.
Anticancer researchGenomic imbalances and microRNA transcriptional profiles in patients with mycosis fungoides.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and MedicineExpression of SOX18 in Mycosis Fungoides.
Acta dermato-venereologicaHow I treat mycosis fungoides and Sézary syndrome.
BloodDifferential NFATc1 Expression in Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoma and Other Forms of Cutaneous T-Cell Lymphoma and Pseudolymphoma.
The American Journal of dermatopathologyIndependent Loss of Methylthioadenosine Phosphorylase (MTAP) in Primary Cutaneous T-Cell Lymphoma.
The Journal of investigative dermatologyMycosis Fungoides: A Retrospective Study of 44 Swedish Cases.
Acta dermato-venereologicaExpression of CXCR4 and CXCL12 and their correlations to the cell proliferation and angiogenesis in mycosis fungoides.
Postepy dermatologii i alergologiiExpression of SATB1, MTI/II and Ki-67 in Mycosis Fungoides.
Anticancer researchCutaneous CD8+ Cytotoxic T-Cell Lymphoma Infiltrates: Clinicopathological Correlation and Outcome of 35 Cases.
Oncology and therapyBrentuximab vedotin in refractory or relapsed peripheral T-cell lymphomas: the French named patient program experience in 56 patients.
HaematologicaMolecular genetic and cytogenetic analysis of a primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma.
International journal of hematologyTherapeutic Update: Update on Cutaneous and Systemic Therapy for Primary Cutaneous T Cell Lymphoma, Mycosis Fungoides.
Journal of drugs in dermatology : JDDMicroRNA-16 mediates the regulation of a senescence-apoptosis switch in cutaneous T-cell and other non-Hodgkin lymphomas.
OncogeneTotal Skin Electron Beam for Primary Cutaneous T-cell Lymphoma.
International journal of radiation oncology, biology, physicsExpression of CD164 on Malignant T cells in Sézary Syndrome.
Acta dermato-venereologicaExpression of MCM-3 and MCM-7 in Primary Cutaneous T-cell Lymphomas.
Anticancer research[Molecular pathogenesis of peripheral T-cell lymphoma (1): angioimmunoblastic T-cell lymphoma, peripheral T-cell lymphoma, not otherwise specified and anaplastic large cell lymphoma].
Medecine sciences : M/SHematopoietic Stem Cell Transplant for Mycosis Fungoides and Sézary Syndrome.
Dermatologic clinicsFolliculotropic Mycosis Fungoides as a Posttransplant Lymphoproliferative Disorder.
PediatricsPrimary cutaneous follicular helper T-cell lymphoma.
Journal of cutaneous pathologyMultiple cutaneous lymphoproliferative disorders showing a retained tumor clone by T-cell receptor gene rearrangement analysis: a case series of four patients and review of the literature.
International journal of dermatologyPrimary Cutaneous T-cell Lymphoma With Coexpression of T-Cell Receptors αβ and γδ.
The American Journal of dermatopathologyRapidly progressive stage IVB mycosis fungoides treated with low-dose total skin electron beam therapy.
OncoTargets and therapyALK-positive primary cutaneous T-cell-lymphoma (CTCL) with unusual clinical presentation and aggressive course.
Journal of cutaneous pathologyPrimary Cutaneous T-cell Lymphoma With Aberrant CD-20 Expression.
Journal of drugs in dermatology : JDDHPyV6, HPyV7 and TSPyV DNA sequences detection in skin disease patients and healthy subjects.
Journal of the European Academy of Dermatology and Venereology : JEADVPagetoid reticulosis tumor cells with double expression of TCRγδ and TCRαβ: an off-target phenomenon or genuine expression?
Journal of cutaneous pathologyAltered microRNA expression in folliculotropic and transformed mycosis fungoides.
Pathology oncology research : POR'We had to change to single beds because I itch in the night': a qualitative study of the experiences, attitudes and approaches to coping of patients with cutaneous T-cell lymphoma.
The British journal of dermatologyRecent advances in primary cutaneous T-cell lymphoma.
Current opinion in oncologyAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- T-cell receptor gamma (TRG) diversity predicts peripheral blood involvement in primary cutaneous T-cell lymphoma.
- Localized palmar mycosis fungoides: A case report.
- Radiotherapy dose-response of mycosis fungoides with large cell transformation.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology· 2026· PMID 41271171mais citado
- Histopathologic Spectrum of Primary Cutaneous T-Cell Lymphomas: Insights From a Vietnamese Case Series.
- Bacterial skin colonization and systemic antibiotic treatment in patients with cutaneous T-cell lymphoma.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG· 2026· PMID 40970830mais citado
- Moderate-Dose Local Radiotherapy in Symptomatic CD30-Positive, Anaplastic Lymphoma Kinase (ALK)-Negative Primary Cutaneous T-cell Lymphoma.
- Hypopigmented CD8+ Mycosis Fungoides in Sri Lanka: Clinicopathologic Evidence for an Indolent Variant.
- Results from a Pilot Study of HyBryte™ (Topical Synthetic Hypericin) Versus Valchlor(®) (Mechlorethamine) in the Treatment of CTCL.
- Molecular Markers Distinguishing Early-Stage Mycosis Fungoides From Atopic Dermatitis Skin Lesions.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:171901(Orphanet)
- MONDO:0015758(MONDO)
- GARD:6226(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q5196687(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
