A micose fungóide (MF) e suas variantes representam as formas mais comuns de linfomas cutâneos de células T. O termo MF é restrito à forma clássica caracterizada pela progressão lenta de manchas, placas e tumores, e a variantes com curso indolente semelhante.
Introdução
O que você precisa saber de cara
A micose fungóide (MF) e suas variantes representam as formas mais comuns de linfomas cutâneos de células T. O termo MF é restrito à forma clássica caracterizada pela progressão lenta de manchas, placas e tumores, e a variantes com curso indolente semelhante.
Tem tratamento?
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 10 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 38 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
3 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
Inhibitory receptor acting as a major negative regulator of T-cell responses (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:18641304, PubMed:28484017). Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:28484017)
Cell membrane
Systemic lupus erythematosus
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells (PubMed:24665965). Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in bo
Cell membraneCell surface
Immunodeficiency 123 with HPV-related verrucosis
An autosomal recessive immunologic disorder characterized by susceptibility to human papilloma virus (HPV) infections and the development of HPV-related common verrucosis in the first decade of life. In some patients with HPV2 infection, warts may progress to severe generalized hyperkeratotic cutaneous papillomatosis with cutaneous horns ('tree-man' phenotype). In patients with HPV4 infection, warts remains stable and may even regress with age.
Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity
Cell membraneSecreted
Medicamentos e terapias
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: C-C chemokine receptor type 4 cross-linking agent
Mecanismo: Dihydrofolate reductase inhibitor
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Glucocorticoid receptor agonist
Mecanismo: Retinoid X receptor agonist
Mecanismo: Tubulin inhibitor
Mecanismo: Opioid receptors; mu/kappa/delta antagonist
Mecanismo: T-cell surface antigen CD4 other
Variantes genéticas (ClinVar)
191 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
14 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Micose fungoide e variantes
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Pesquisa e ensaios clínicos
0 ensaios clínicos encontrados.
Publicações mais relevantes
BK polyomavirus-associated progressive multifocal leukoencephalopathy following mogamulizumab therapy for erythrodermic mycosis fungoides.
BK polyomavirus (BKPyV) is a ubiquitous human pathogen that typically causes nephropathy and hemorrhagic cystitis in immunocompromised patients. Although BKPyV shares close genetic and structural similarity with JC polyomavirus (JCPyV), which is responsible for progressive multifocal leukoencephalopathy (PML), its neurotropic potential remains poorly characterized. Rare reports have suggested possible central nervous system (CNS) involvement under conditions of severe immune suppression. Here, we describe the first documented case of BKPyV-associated PML in a patient with erythrodermic mycosis fungoides treated with Mogamulizumab, a CCR4-targeting monoclonal antibody that profoundly alters immune surveillance. We describe a patient with erythrodermic mycosis fungoides and long-standing immunological frailty, who developed neurological symptoms during Mogamulizumab therapy. Brain MRI showed multifocal white matter lesions compatible with PML. BKPyV DNA was detected in plasma, urine, and cerebrospinal fluid (CSF), while JCPyV DNA was absent. Serological testing showed high anti-BKPyV and anti-JCPyV IgG levels in plasma, indicating prior exposure to both viruses, while antibodies were undetectable in CSF, consistent with lack of intrathecal synthesis. This compartmental dissociation between plasma and CSF, together with the detection of BKPyV DNA and the absence of JCPyV DNA in CSF, supports BKPyV as the etiological neurotropic agent responsible for leukoencephalopathy. Sequencing of the VP1 and NCCR regions revealed compartment-specific nucleotide and amino acid variants, including non-conservative substitutions in the CSF isolate, suggesting intra-host viral heterogeneity. Compartment-specific sequence variability of viral protein 1 (VP1) and structural rearrangements of the non-coding control region (NCCR), particularly the loss of the Q and R block in CSF-derived isolates, underscore intra-host heterogeneity of BKV and may contribute to its adaptation and neurotropic potential. This is the first documented case of BKPyV-associated PML in a Mogamulizumab-treated patient. These findings highlight intra-host heterogeneity at the protein level, possibly reflecting compartment-specific viral evolution, and underscore the need for vigilant BKPyV and JCPyV monitoring during Mogamulizumab treatment.
Evaluation of immunohistochemical and gene expression of Janus kinase1 and Janus kinase3 in the skin of different clinical types of mycosis fungoides patients - Part II: reverse transcriptase-polymerase chain reaction.
Mycosis Fungoides (MF) is the commonest type of primary cutaneous T-Cell lymphomas representing about 50% of all lymphomas arising primarily in the skin. Janus kinases are non-receptor intracellular tyrosine kinases that play an important role in the pathogenesis of variant skin disorders and several hematological malignancies. The aim of this study was to investigate the gene expression of Janus Kinase-1 (JAK1) and Janus Kinase-3 (JAK3) in the skin of different types of MF patients using Real-time Quantitative Reverse Transcription Polymerase Chain Reaction (RT-PCR). The current study included 53 patients with MF, and 53 control samples. RT-PCR for JAK1 and JAK3 was done in the skin specimens obtained from patients and controls. Both JAK1 and JAK3 fold changes showed stepwise upregulation in lesional MF skin than normal control skin, with statistically significant increase in MF patients than healthy controls (p < 0.001 and < 0.001 respectively). JAK1 was significantly upregulated in early-stage MF than JAK3 (p < 0.001). Limitations of this study include the small sample size of some mycosis fungoides variants, such as erythrodermic MF. Further studies are needed to clarify the functional role of Janus kinase signaling pathways in MF pathogenesis. Both JAK1 and JAK3 play a role in the pathogenesis of MF. JAK1 may have a pathogenic role, particularly in the early stage of cutaneous T-cell lymphoma. This potentiates the idea of using JAK1 and JAK3 inhibitors for MF treatment.
Evaluation of immunohistochemical and gene expression of Janus kinase 1 and Janus kinase 3 in the skin of different clinical types of mycosis fungoides patients - Part 1.
Mycosis fungoides is the commonest type of cutaneous T-Cell lymphoma. Janus kinases are intracellular tyrosine kinases that have recently been proven to have a crucial role in the pathogenesis and progression of several dermatological and malignant diseases. The aim of this study was to investigate the immunohistochemical expression of Janus Kinase-1 (JAK1) and Janus Kinase-3 (JAK3) in the skin of mycosis fungoides . The current study included 46 patients with early-stage MF, and 7 patients with late-stage MF, and 53 control samples. Immunohistochemical staining using JAK1 and JAK3 monoclonal antibodies was done in the skin specimens obtained from patients and controls. The evaluation of JAK1 and JAK3 gene expression using RT-PCR will be included in part 2 of the study. JAK1 immunohistochemical expression was nuclear, and JAK3 was cytoplasmic in MF patients. Immunoreactivity scores for JAK1 and JAK3 in MF patients were significantly increased compared to healthy controls (p < 0.001 and < 0.001, respectively). JAK1 and JAK3 immunoreactivity scores were significantly higher in the tumor than in the patch and plaque stages of MF (P7 = 0.001 and 0.004, respectively). This study is limited by the relatively small sample size of some clinical variants of mycosis fungoides, particularly advanced forms such as erythrodermic and tumor-stage MF. Further studies are needed to evaluate JAK1 and JAK3 expression following therapeutic interventions, including phototherapy and JAK inhibitors. JAK1 and JAK3 were significantly expressed in MF skin lesions in comparison to normal controls. JAK1 and JAK3 were more expressed in the tumor stage than patch and plaque stage MF, suggesting that JAK1 and JAK3 could play a crucial role in MF pathogenesis, progression, and prognosis.
A historical review of mycosis fungoides: from Alibert to mogamulizumab.
In 1806, French physician Baron Jean-Louis Alibert saw a man with a desquamating rash and skin tumours. Alibert considered this to be a variant of yaws. In 1829 Alibert named the condition mycosis fungoides (MF), meaning 'mushroom-like fungal disease'. Over 100 years later, French dermatologist Albert Sézary published papers from 1938 to 1949 detailing a mysterious disease containing 'cellules monstrueuses', describing cutaneous 'monster cells'. In 1961, these clinical findings were collated together into 'Sézary syndrome'. In the 1870s English dermatologist William Tilbury Fox published a dermatology atlas detailing cases similar to what we know now as MF, with the name 'fibroma fungoides'. The atlas described MF as a type of fungus, before giving a description of yaws and painting a clinical picture that differed from that of a lymphoma. Over the twentieth century, our understandings of the origins of MF were changing and by 1975 the classification system and term we now recognize as cutaneous T-cell lymphoma (CTCL) was developed. Neoplastic cells have been thought to arise from chronic activation of T cells via antigen-presenting cells due to inappropriate cytokines and C-C chemokine receptors. In 2018, the World Health Organization and European Organisation for Research and Treatment of Cancer officially recognized four variants of MF. These are the classic Alibert-Bazin variant and its three variants: folliculotropic MF, pagetoid reticulosis and granulomatous slack skin. Developments in immunohistochemistry for the T-cell receptor gene in the 1990s improved the diagnosis of CTCL; however, diagnosis is still challenging. Advanced MF therapies have evolved from cytotoxic chemotherapy to novel monoclonal antibodies such as mogamulizumab, targeting proteins on T-cell lymphoma cells.
Adult-Onset Hypopigmented Mycosis Fungoides: A Systematic Review of Clinicopathologic, Immunophenotypic, and Therapeutic Characteristics.
Background/Objectives: Hypopigmented mycosis fungoides (hMF) is a rare variant of mycosis fungoides (MF) often seen in younger patients and individuals with darker skin phototypes. The lesions develop as hypopigmented patches or plaques, and they are usually asymptomatic and respond well to topical treatment or phototherapy. Methods: We provide a systematic review on hMF with onset at or beyond 30 years of age, based on SCOPUS, PubMed, and Embase databases. A total of 13 original articles, totaling 34 patients, were included in this review. Evidence was limited to case reports and small series; PROSPERO registration is CRD420251181894. Results: The majority of cases did not progress beyond stage IB and commonly used treatment methods, including topical corticosteroids and phototherapy. In three patients, a progression of the disease occurred, and in two of them it was fetal. Among patients receiving phototherapy, PUVA therapy achieved complete remission more often than UVB (13 out of 17 cases vs. 8 out of 16 cases). Although recurrences occurred with both treatments, they were less frequent, and relapses took longer to develop in the PUVA group. Conclusions: In this cohort, PUVA appeared to be associated with higher complete response rates and longer remission duration than UVB. However, this advantage of PUVA is derived from low-level evidence and should be confirmed in prospective comparative studies.
Publicações recentes
Real-World Outcomes of Mycosis Fungoides and Site-Specific Nodal Involvement: A Registry-Based Study of 25 467 Patients.
A First-of-Its-Kind Case of Annular Lichenoid Dermatitis of Youth (ALDY) From Kuwait.
Self-supervised AI system for differentiating mycosis fungoides and benign inflammatory dermatoses.
Persistence of sex differences and stable trends in mortality in patients with mycosis fungoides and Sézary syndrome in Spain (1983-2022).
BK polyomavirus-associated progressive multifocal leukoencephalopathy following mogamulizumab therapy for erythrodermic mycosis fungoides.
📚 EuropePMC2 artigos no totalmostrando 198
Evaluation of immunohistochemical and gene expression of Janus kinase1 and Janus kinase3 in the skin of different clinical types of mycosis fungoides patients - Part II: reverse transcriptase-polymerase chain reaction.
Anais brasileiros de dermatologiaEvaluation of immunohistochemical and gene expression of Janus kinase 1 and Janus kinase 3 in the skin of different clinical types of mycosis fungoides patients - Part 1.
Anais brasileiros de dermatologiaBK polyomavirus-associated progressive multifocal leukoencephalopathy following mogamulizumab therapy for erythrodermic mycosis fungoides.
Frontiers in cellular and infection microbiologyEfficacy and tolerability of mogamulizumab in mycosis fungoides and Sézary Syndrome: a monocentric retrospective study.
Frontiers in oncologyA historical review of mycosis fungoides: from Alibert to mogamulizumab.
Skin health and diseaseAdult-Onset Hypopigmented Mycosis Fungoides: A Systematic Review of Clinicopathologic, Immunophenotypic, and Therapeutic Characteristics.
CancersA Case of Folliculotropic Mycosis Fungoides Initially Misleading as a Poikilodermatous Rash: The Importance of Gene Rearrangement Testing in Early-Stage Disease (Folliculotropic T-Cell Lymphocytosis).
CureusRelapsed/refractory mycosis fungoides and Sezary syndrome: biology, clinical manifestations and therapeutic options.
Leukemia & lymphomaImmunoprofiling Reveals GATA3 as a Prognostic Marker in Transformed Mycosis Fungoides.
The Journal of dermatologyRapidly Progressing CD8-negative Hypopigmented Mycosis Fungoides in Adult Caucasian Male with Good Response to Mogamulizumab.
Acta dermato-venereologicaExtensive Alopecia Mucinosa and Response to Brentuximab Vedotin: A Case Report.
Skin appendage disordersAn Unusual Case of Primary Mucocutaneous Cytotoxic T-Cell Lymphoma With Epidermotropism and Phenotype Switch: Diagnostic and Molecular Insights.
Journal of cutaneous pathologyEarly-Onset Hypopigmented Mycosis Fungoides in a Young Female: Navigating Diagnostic Delays and Treatment Complexities-A Case Report.
Clinical case reportsRetrospective Analysis of Second Primary Malignancies in Patients with Mycosis Fungoides and Sézary Syndrome in Croatia.
Dermatology practical & conceptualCD30-Positive Lymphoproliferative Disorder With DUSP22-IRF4 Rearrangement and Gamma-Delta T-Cell Phenotype: A Novel Indolent Presentation.
Journal of cutaneous pathologyPrimary Cutaneous Diffuse Large B-Cell Lymphoma With Initial Atypical Clinical Presentation as Annular and Arcuate Plaques, Histologically Mimicking Interstitial Granulomatous Dermatitis.
The American Journal of dermatopathologyAtrophic Pityriasis Versicolor: 3 Case Reports.
Case reports in dermatologyA Case of Cutaneous T-cell Lymphoma: The Importance of a Dermatology Consultation.
CureusPediatric Papular Mycosis Fungoides Treated With Phototherapy: A Case Series.
Pediatric dermatologyVesiculobullous Eruption in Patient With Mycosis Fungoides.
The American Journal of dermatopathologyUnexpected Diagnosis in a Cutaneous Tumoral Lesion: Primary Cutaneous Leg-Type B-Cell Lymphoma.
CureusSuccessful Treatment of Poikilodermatous Mycosis Fungoides with 308-nm Excimer Laser.
Case reports in oncologyClinical and Prognostic Features of Erythrodermic Cutaneous T-Cell Lymphoma: A Retrospective Study of 35 Patients.
Turkish journal of haematology : official journal of Turkish Society of HaematologyDurable Remission after Allogeneic Hematopoietic Stem Cell Transplantation (Allo-HSCT) for Refractory Mycosis Fungoides: A Case Report.
International journal of hematology-oncology and stem cell researchFolliculotropic Mycosis Fungoides Masquerading as Nodulocystic Acne: A Diagnostic Challenge.
CureusFamily and Quality of Life Challenges in Mycosis Fungoides Patients: A Case-Control Study from Shiraz, Southern Iran.
Dermatology practical & conceptual[Poikilodermatous mycosis fungoides].
Dermatologie (Heidelberg, Germany)An illustrative case of hypopigmented mycosis fungoides.
SAGE open medical case reportsAnaplastic large cell lymphoma: unusual clinical and pathologic findings: A report of the 2023 SH-EA4HP Lymphoma Workshop.
American journal of clinical pathologyZosteriform Mycosis Fungoides: A Case Report and Literature Review.
The American Journal of dermatopathologyStructural Insights into the ADCC Mechanism and Resistance of Mogamulizumab, a First-in-Class Anti-CCR4 Therapy for Cutaneous T Cell Lymphoma.
International journal of molecular sciencesFolliculosebaceous Cystic Hamartoma With Unusual Mucinosis: A Report of a Rare Case.
CureusAlopecia Mimicking Lichen Planopilaris in a Patient with Mycosis Fungoides.
Skin appendage disordersISCL/EORTC-CLTG/USCLC recommendations for the diagnosis, staging and treatment of early-stage paediatric mycosis fungoides: a modified Delphi consensus. Part one: diagnosis and staging.
The British journal of dermatologyISCL/EORTC-CLTG/USCLC recommendations for the diagnosis, staging and treatment of early-stage paediatric mycosis fungoides: a modified Delphi consensus. Part two: treatment.
The British journal of dermatologyThyroid Dysfunction in Mycosis Fungoides: Sonographic and Laboratory Insights.
Dermatology practical & conceptualOverexpression of FOXM1 drives mycosis fungoides progression by regulating the cell cycle.
Journal of dermatological sciencePhotodynamic Therapy in Primary Cutaneous Skin Lymphoma-Systematic Review.
Journal of clinical medicineA Case Report on Juvenile Folliculotropic Mycosis Fungoides: A Misleading Disease.
CureusA rare case of mycosis fungoides with porokeratosis-like lesions: a case report and review of previous literature.
AME case reportsDermoscopy of folliculotropic mycosis fungoides of the scalp: a pediatric case report with comparative trichoscopic analysis.
Dermatology reportsDermoscopic and trichoscopic features of follicular mycosis fungoides: a systematic review.
Italian journal of dermatology and venereologySuccessfully maintained complete remission of mycosis fungoides by umbilical cord blood transplantation: a case report and literature review.
Dermatology reportsCentral Nervous System Manifestations of Cutaneous Lymphomas.
Current neurology and neuroscience reportsMelano-erythrodermic folliculotropic mycosis fungoides misdiagnosed as a case of recalcitrant atopic dermatitis: A case report.
SAGE open medical case reportsHDAC10 and its implications in Sézary syndrome pathogenesis.
Frontiers in cell and developmental biologyT-cell lymphoproliferative disorder with a STAT3 mutation causing a lymphocytic variant of hypereosinophilic-like syndrome without eosinophilia.
Journal of hematopathologyCoexistence of T-Cell Lymphoblastic Lymphoma and Ichthyosis Vulgaris: A Case Report.
Case reports in oncological medicineManagement of mycosis fungoides and Sézary syndrome with mogamulizumab in combination with psoralen plus UVA: two case reports.
Therapeutic advances in hematologyComparison of Pediatric- and Adult-Onset Mycosis Fungoides Patients in Terms of Clinical Features and Prognosis in a Large Series.
Journal of cutaneous medicine and surgeryA Yale Dermatology perspective on cutaneous T cell lymphoma: Historic reflection to emerging therapies.
Clinics in dermatologyCD4/CD8 double-negative mycosis fungoides: a review.
Dermatology reportsZosteriform mycosis fungoides: case report of progression to tumor stage and review of the literature.
Dermatology online journalA Case Report of Folliculotropic Mycosis Fungoides: Diagnostic Criteria and Treatment Strategy.
Cureus[Hypopigmented mycosis fungoide. Case report].
Revista medica del Instituto Mexicano del Seguro SocialFolliculotropic mycosis fungoides with leukaemic involvement in middle childhood: a rare encounter.
BMJ case reportsRadiation therapy for a case of poikilodermatous plaques in an otherwise healthy young man: A case report.
SAGE open medical case reportsSeborrheic keratosis-like mycosis fungoides: A rare variant with clinical, dermatoscopic, and dermatopathological features.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGPathogenic variants of mycosis fungoides identified using next-generation sequencing.
Journal of hematopathologyWhen mycosis fungoides seems not to be within the spectrum of clinical and histopathological differential diagnoses.
Dermatology reportsClinical and Histologic Variants of CD8+ Cutaneous T-Cell Lymphomas.
CancersBeyond the pale: Insights into hypopigmented mycosis fungoides - A case report.
Malaysian family physician : the official journal of the Academy of Family Physicians of Malaysia[Bullous mycosis fungoides-clinical indicator for an aggressive course of disease].
Dermatologie (Heidelberg, Germany)Atypical presentation of γ/δ mycosis fungoides with an unusual phenotype and SOCS1 mutation.
Open life sciencesA case report of refractory advanced-stage mycosis fungoides: successful treatment and improved patient quality of life with mogamulizumab.
Therapeutic advances in hematologyCutaneous Lymphoma in a Tertiary Skin Hospital and Referral Centre in Nepal.
Journal of Nepal Health Research CouncilMycosis Fungoides Palmaris et Plantaris Mimicking "Dyshidrotic Eczema": A Case Report.
Journal of drugs in dermatology : JDDReport on a Rare Case of Limited CD4/CD8 Double-Positive Paget Reticulosis with Literature Review.
Clinical, cosmetic and investigational dermatologyNull T-cell phenotype mycosis fungoides with aberrant CD20 and CD56 expression: A diagnostic dilemma.
Journal of cutaneous pathologyFolliculotropic mycosis fungoides associated with follicular mucinosis: A case report and mini review.
Clinical case reportsVitamin D in Cutaneous T-Cell Lymphoma.
CellsLymphomatoid Papulosis With T-cell Receptor-Gamma Delta Expression: A Clinicopathologic Case-series of 26 Patients of an Underrecognized Immunophenotypic Variant of Lymphomatoid Papulosis.
The American journal of surgical pathologyWaxy papules, infiltrated alopecic plaques, and shin ichthyosis.
International journal of dermatologyPigmented purpura dermatosis-like mycosis fungoides: four case reports and a review of published cases.
European journal of dermatology : EJDImmunobiology and treatment of cutaneous T-cell lymphoma.
Expert review of clinical immunologyRisk of progression of early-stage mycosis fungoides, 10-year experience.
Anais brasileiros de dermatologiaClinical, histopathological and immunohistochemical evaluation of ultraviolet A1 treatment in early-stage mycosis fungoides.
Photodermatology, photoimmunology & photomedicineCutaneous T-Cell Lymphoma (CTCL) Arising Post Kidney Transplant: A Review of Clinical Variants in the Literature.
Hematology reportsSuccessful anti-tumor effects with two novel bifunctional chemotherapeutic compounds that combine a LAT1 substrate with cytotoxic moieties in aggressive T-cell lymphomas.
Leukemia research reportsDeciphering Tumor Cell Evolution in Cutaneous T-Cell Lymphomas: Distinct Differentiation Trajectories in Mycosis Fungoides and Sézary Syndrome.
The Journal of investigative dermatologyFolliculotropic Mycosis Fungoides In A Child: A Rare Case.
JPMA. The Journal of the Pakistan Medical AssociationDermoscopy in the Diagnosis of Mycosis Fungoides: Can it Help?
Dermatology practical & conceptualFolliculotropic Mycosis Fungoides Is Associated with Decreased PD1 Staining Compared with Classic Mycosis Fungoides.
Dermatopathology (Basel, Switzerland)Primary cutaneous T-cell lymphoma: a review of the most common entities with focus on recent updates.
Human pathologyCase Report: Mycosis fungoides as an exclusive manifestation of common variable immunodeficiency in a family with a NFKB2 gene mutation.
Frontiers in oncologymAb14, a Monoclonal Antibody against Cell Surface PCNA: A Potential Tool for Sezary Syndrome Diagnosis and Targeted Immunotherapy.
Cancers[Eczema and its treatment in older adults].
Dermatologie (Heidelberg, Germany)Clinical Outcomes of COVID-19 in Mycosis Fungoides and Sezary Syndrome.
Acta haematologicaPaediatric Mycosis Fungoides: Clinical Variants, Treatment Modalities and Response to Therapy.
Acta dermato-venereologicaEyelid involvement of primary cutaneous lymphomas: A clinical perspective.
The Australasian journal of dermatologyFollicular mycosis fungoides: Clinicohistopathologic features and outcomes in a series of 12 Chinese cases.
Indian journal of dermatology, venereology and leprologyEmergence of Malignant T-Cell Intraclonal CDR3 Variants in Mycosis Fungoides.
JAMA dermatologyUnusual case of adult-onset cutaneous lupus erythematosus mimicking early mycosis fungoides.
Oxford medical case reportsSpatially Guided and Single Cell Tools to Map the Microenvironment in Cutaneous T-Cell Lymphoma.
CancersTwo Different Variants of Mycosis Fungoides (Hypopigmented Mycosis Fungoides and Mycosis Fungoides Palmaris et Plantaris) Occurring Simultaneously in a Single Patient.
Indian journal of dermatologyMycosis fungoides and Sézary syndrome: clinical presentation, diagnosis, staging, and therapeutic management.
Frontiers in oncologyPityriasis Lichenoides-Like Mycosis Fungoides: A Case Report.
CureusClinicopathologic characteristics and outcomes of patients with mycosis fungoides: A single tertiary center retrospective analysis in Saudi Arabia.
Saudi medical journalAre we there yet? cellular therapies for cutaneous T cell lymphoma.
Current research in translational medicineLymphomatoid papulosis with DUSP22-IRF4 rearrangement: A case report and literature review.
Journal of cutaneous pathologyMycosis fungoides with Psoriasiform plaques: A case report and review of the literature.
Clinical case reportsHypopigmented Mycosis Fungoides in an 11-Year-Old Palestinian Boy.
Case reports in dermatological medicineMultidisciplinary Approach to the Diagnosis and Therapy of Mycosis Fungoides.
Healthcare (Basel, Switzerland)Distribution and clinical features of lymphomas involving skin in Taiwan.
The Kaohsiung journal of medical sciencesSuggested Guidelines for the Treatment of Mycosis Fungoides in Countries with Limited Resources.
Dermatology research and practiceSome New Aspects of Genetic Variability in Patients with Cutaneous T-Cell Lymphoma.
GenesSyringotropic Mycosis Fungoides: A Variant of Folliculotropic or a Distinct Subtype of Adnexotropic Mycosis Fungoides?
Journal of drugs in dermatology : JDDMechlorethamine Hydrochloride Gel in the Treatment of Mycosis Fungoides-Type Cutaneous T-Cell Lymphoma (MF-CTCL): A Focus on Patient Selection and Special Considerations.
Cancer management and researchDiagnostic Outcomes and Treatment Modalities in Patients with Mycosis Fungoides in West Sweden-A Retrospective Register-Based Study.
CancersUnraveling the Structural Variations of Early-Stage Mycosis Fungoides-CD3 Based Purification and Third Generation Sequencing as Novel Tools for the Genomic Landscape in CTCL.
CancersFolliculotropic Mycosis Fungoides: Current Guidance and Experience from Clinical Practice.
Clinical, cosmetic and investigational dermatologyInterstitial Mycosis Fungoides: An Unusual Mimic of Interstitial Granuloma Annulare Not to Miss.
Case reports in dermatological medicine[Quality of life of patients with mycosis fungoides and Sézary syndrome].
Dermatologie (Heidelberg, Germany)Pityriasis Lichenoides Et Varioliformis Acuta and Lymphomatoid Papulosis Type F: A Case Report of Two Entities in One Patient.
Clinical, cosmetic and investigational dermatologyFolliculotropic Mycosis Fungoides in a Latin American Hospital: Survival Analysis.
Actas dermo-sifiliograficasExtragenital lichen sclerosus: A comprehensive review.
The Australasian journal of dermatologyLocalized lymphomatoid papulosis: Unilesional lymphomatoid papulosis, regional lymphomatoid papulosis, and persistent agmination of lymphomatoid papulosis.
Clinics in dermatologyDeepening the observation of mycosis fungoides through dermoscopy: definition of the dermoscopic profiles of its progression stages and variants.
Journal of the European Academy of Dermatology and Venereology : JEADVCD4/CD8 double-negative mycosis fungoides with large cell transformation and involvement of the lungs and leptomeninges.
Dermatology online journalHyper-IgE and Carcinoma in CADINS Disease.
Frontiers in immunologyPaediatric mycosis fungoides - characteristics, management and outcomes with particular focus on the folliculotropic variant.
Journal of the European Academy of Dermatology and Venereology : JEADVWoringer-Kolopp disease (localized pagetoid reticulosis): a systematic review.
International journal of dermatologyOncolytic effect of SARS-CoV-2 in a patient with mycosis fungoides: A case report.
Clinical case reports[Mycosis fungoides and Sézary syndrome : a systematic review].
Revue medicale suisseDermoscopic spectrum of mycosis fungoides: a retrospective observational study by the International Dermoscopy Society.
Journal of the European Academy of Dermatology and Venereology : JEADVUnderstanding Cell Lines, Patient-Derived Xenograft and Genetically Engineered Mouse Models Used to Study Cutaneous T-Cell Lymphoma.
CellsHyperpigmented mycosis fungoides: a retrospective and comparative analysis with other subtypes of mycosis fungoides.
Leukemia & lymphomaMalignant T Cell Activation by a Bacillus Species Isolated from Cutaneous T-Cell Lymphoma Lesions.
JID innovations : skin science from molecules to population healthGenomic Analysis of Cutaneous CD30-Positive Lymphoproliferative Disorders.
JID innovations : skin science from molecules to population healthThe Role of microRNA in Pathogenesis, Diagnosis, Different Variants, Treatment and Prognosis of Mycosis Fungoides.
Frontiers in oncologyInterleukin (IL)-33 immunobiology in asthma and airway inflammatory diseases.
The Journal of asthma : official journal of the Association for the Care of AsthmaCD8+ mycosis fungoides with ichthyosiform clinical presentation and angiocentric feature.
Journal of cutaneous pathologyUse of Ultrasound to Observe Mycosis Fungoides: A Case Report and Review of Literature.
Current medical imagingUnderstanding the enigmatic association between mycosis fungoides and psoriasis: Report of two cases and review of the literature.
Metabolism openIsolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling.
Journal of visualized experiments : JoVENew insights into granulomatous mycosis fungoides (GMF): a single-center experience.
European journal of cancer (Oxford, England : 1990)Primary cutaneous lymphomas in children: A prospective study from the Spanish Academy of Dermatology and Venereology (AEDV) Primary Cutaneous Lymphoma Registry.
Pediatric dermatologyManagement of a Unique Presentation of a Common Dermatologic Condition.
Spartan medical research journalClinical characteristics and prognostic factors of 70 patients with Sézary syndrome: a single-institutional experience at Moffitt cancer center.
Leukemia & lymphomaInterleukin 36 expression in psoriasis variants and other dermatologic diseases with psoriasis-like histopathologic features.
Journal of cutaneous pathologyEvaluation of Melanocyte Loss in Mycosis Fungoides Using SOX10 Immunohistochemistry.
Dermatopathology (Basel, Switzerland)Primary Cutaneous Lymphomas in Thailand: A 10-Year Retrospective Study.
BioMed research internationalMultimodal single-cell analysis of cutaneous T-cell lymphoma reveals distinct subclonal tissue-dependent signatures.
BloodA Previously Unrecognized Granulomatous Variant of Gamma-Delta T-Cell Lymphoma.
Dermatopathology (Basel, Switzerland)Clinical characteristics and long-term outcome of 223 patients with mycosis fungoides at a single tertiary center in Korea: A 29-year review.
Journal of the American Academy of DermatologyHypopigmented mycosis fungoides mimicking leprosy successfully treated with oral and topical corticosteroids: a new great imitator?
Acta dermatovenerologica Alpina, Pannonica, et AdriaticaClinical variants of mycosis fungoides in a cohort.
Gaceta medica de MexicoDermoscopic Features of Mycosis Fungoides and Its Variants in Patients with Skin of Color: A Retrospective Analysis.
Dermatology practical & conceptual[Papular mycosis fungoides in elderly: Report of two cases].
Revista espanola de geriatria y gerontologiaIntegrated genomic analyses of cutaneous T-cell lymphomas reveal the molecular bases for disease heterogeneity.
BloodDifferent aspects and variants of mycosis fungoides in a single patient.
Indian journal of dermatology, venereology and leprologyAdnexotropic Variants of the Interface Dermatitides: A Review.
Dermatopathology (Basel, Switzerland)Diagnosis and Management of Cutaneous Lymphomas Including Cutaneous T-cell Lymphoma.
The Medical clinics of North AmericaSerum and cutaneous transcriptional expression levels of IL31 are minimal in cutaneous T cell lymphoma variants.
Biochemistry and biophysics reportsClinical and trichoscopic features in 18 cases of Folliculotropic Mycosis Fungoides with scalp involvement.
Scientific reportsClinical characteristics and long-term outcomes of 97 Korean patients with mycosis fungoides.
International journal of dermatologyPrimary cutaneous T-cell lymphomas in childhood and adolescence.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGCell signaling in cutaneous T-cell lymphoma microenvironment: promising targets for molecular-specific treatment.
International journal of dermatologyErythrodermic CD4/CD8 Double-Negative Mycosis Fungoides: A Case Report.
Case reports in oncologyMycosis Fungoides in Children and Adolescents: A Systematic Review.
JAMA dermatologyMycosis Fungoides with Dermal Mucin Deposition: An Unusual Variant of the Most Challenging Primary Cutaneous Lymphoma.
Case reports in dermatologyPembrolizumab in mycosis fungoides with PD-L1 structural variants.
Blood advancesGranulomatous slack skin variant of mycosis fungoides: Clinical and dermoscopic follow-up of a very rare entity.
Dermatologic therapyAcneiform Presentations of Folliculotropic Mycosis Fungoides.
The American Journal of dermatopathologyJAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL).
CancersInterstitial granuloma after interferon-gamma and narrowband UVB therapy in a patient with mycosis fungoides: Immunological and histopathological considerations.
Journal of cutaneous pathologySecondary hypereosinophilic syndrome: an unusual manifestation in a patient with syringotropic mycosis fungoides and human immunodeficiency virus infection.
The Australasian journal of dermatologyCutaneous T-cell lymphoma mimicking palmoplantar pustular psoriasis: A rare variant.
The Australasian journal of dermatologyLichen aureus with pseudolymphomatous infiltrate.
Journal of cutaneous pathologyAdult T-cell leukemia/lymphoma clinically confused with viral/drug skin eruptions and pathologically misinterpreted as mycosis fungoides/Sézary syndrome.
Journal of cutaneous pathologyWoringer-Kolopp Disease of the Foot: A Case Report.
Journal of the American Podiatric Medical AssociationHypopigmented Mycosis Fungoides: A Clinical and Histopathology Analysis in 9 Children.
The American Journal of dermatopathologyA Rare Case of Poikilodermatous Mycosis Fungoides.
Indian journal of dermatologyHypopigmented Mycosis Fungoides Mimicking Vitiligo.
The American Journal of dermatopathologyEpidemiological changes in cutaneous lymphomas: an analysis of 8593 patients from the French Cutaneous Lymphoma Registry.
The British journal of dermatologyComparison between the histopathological and immunophenotypical features of hypopigmented and nonhypopigmented mycosis fungoides: A retrospective study.
Journal of cutaneous pathologyMycosis Fungoides Palmaris et Plantaris on the Plantar Aspect of the Foot: A Case Report.
The American journal of case reportsCollisional variant of CD8+ mycosis fungoides and indolent CD8+ lymphoid proliferation.
JAAD case reportsSingle-Cell Heterogeneity of Cutaneous T-Cell Lymphomas Revealed Using RNA-Seq Technologies.
CancersHypopigmented Mycosis Fungoides: Loss of Pigmentation Reflects Antitumor Immune Response in Young Patients.
CancersAggressive CD4/CD8 Double-Negative Primary Cutaneous T-Cell Lymphoma With Dural Invasion: A Rare Presentation of Mycosis Fungoides?
The American Journal of dermatopathologyRare case of CD8+ CD56+ cytotoxic variant of mycosis fungoides clinically presenting with a combination of hypopigmentation and poikiloderma.
International journal of dermatologyKi67 and CD31 Differential Expression in Cutaneous T-Cell Lymphoma and Its Mimickers: Association with Clinicopathological Criteria and Disease Advancement.
Clinical, cosmetic and investigational dermatologyStage-dependent Increase in Expression of miR-155 and Ki-67 and Number of Tumour-associated Inflammatory Cells in Folliculotropic Mycosis Fungoides.
Acta dermato-venereologicaIs it mycosis fungoides? A comprehensive guide to reaching the diagnosis and avoiding common pitfalls.
Annals of diagnostic pathologyLichen planus follicularis tumidus: Immunotyping of the inflammatory infiltrate with focus on plasmacytoid dendritic cells.
Journal of cutaneous pathologyA Case Report of Pityriasis Lichenoides-Like Mycosis Fungoides in Children: A Challenging Diagnosis.
Korean journal of family medicineNew Insights Into the Complex Mutational Landscape of Sézary Syndrome.
Frontiers in oncologyCutaneous T-cell lymphoma: aetiopathogenesis and current diagnostic and therapeutic developments.
European journal of dermatology : EJDPatch-type granuloma annulare: An institution-based study of 23 cases.
Journal of cutaneous pathology[Clinical heterogeneity of poikilodermatous mycosis fungoides: A retrospective study of 12 cases].
Annales de dermatologie et de venereologieInsights Into the Molecular and Cellular Underpinnings of Cutaneous T Cell Lymphoma.
The Yale journal of biology and medicinePilot Study of a Novel Therapeutic Approach for Refractory Advanced Stage Folliculotropic Mycosis Fungoides.
Acta dermato-venereologicaMycosis Fungoides, Lymphomatoid Papulosis and Hodgkin's Lymphoma in the Same Patient: Apropos of a Possible Monoclonal Origin.
Indian journal of dermatologyMycosis Fungoides and Variants of Mycosis Fungoides: A Retrospective Study of 93 Patients in a Chinese Population at a Single Center.
Annals of dermatology[LINEAR MYCOSIS FUNGOIDES IN A BLASCHKOID DISTRIBUTION].
HarefuahThymocyte selection-associated high-mobility group box as a potential diagnostic marker differentiating hypopigmented mycosis fungoides from early vitiligo: A pilot study.
Indian journal of dermatology, venereology and leprologyPagetoid reticulosis in a 13-year old female. A unique immunohistochemical profile.
Journal of cutaneous pathologyAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Micose fungoide e variantes.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Micose fungoide e variantes
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- BK polyomavirus-associated progressive multifocal leukoencephalopathy following mogamulizumab therapy for erythrodermic mycosis fungoides.
- Evaluation of immunohistochemical and gene expression of Janus kinase1 and Janus kinase3 in the skin of different clinical types of mycosis fungoides patients - Part II: reverse transcriptase-polymerase chain reaction.
- Evaluation of immunohistochemical and gene expression of Janus kinase 1 and Janus kinase 3 in the skin of different clinical types of mycosis fungoides patients - Part 1.
- A historical review of mycosis fungoides: from Alibert to mogamulizumab.
- Adult-Onset Hypopigmented Mycosis Fungoides: A Systematic Review of Clinicopathologic, Immunophenotypic, and Therapeutic Characteristics.
- Real-World Outcomes of Mycosis Fungoides and Site-Specific Nodal Involvement: A Registry-Based Study of 25 467 Patients.
- A First-of-Its-Kind Case of Annular Lichenoid Dermatitis of Youth (ALDY) From Kuwait.
- Self-supervised AI system for differentiating mycosis fungoides and benign inflammatory dermatoses.
- Persistence of sex differences and stable trends in mortality in patients with mycosis fungoides and Sézary syndrome in Spain (1983-2022).
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:178566(Orphanet)
- MONDO:0015821(MONDO)
- GARD:20166(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q55785742(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
