Polimiosite

A Study to Investigate the Efficacy and Safety of Anifrolumab Administered as Subcutaneous Injection and Added to Standard of Care Compared With Placebo Added to Standard of Care in Adult Participants With Idiopathic Inflammatory Myopathies (Polymyositis and Dermatomyositis)

NCT06455449

Environmental Risk Factors for the Anti-synthetase Syndrome

NCT01276470

RESET-Myositis: An Open-Label Study to Evaluate the Safety and Efficacy of CABA-201 in Subjects With Active Idiopathic Inflammatory Myopathy or Juvenile Idiopathic Inflammatory Myopathy

NCT06154252

A Study to Understand How the Study Medicine Dazukibart Works in People With Idiopathic Inflammatory Myopathies

NCT06698796

Adult and Juvenile Myositis

NCT00017914

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NCT01276470 · Environmental Risk Factors for the Anti-synthetase SyndromeRecrutando

NCT06154252 · RESET-Myositis: An Open-Label Study to Evaluate the Safety a…Recrutando

PHASE2, PHASE3

NCT06698796 · A Study to Understand How the Study Medicine Dazukibart Work…Recrutando

NCT00017914 · Adult and Juvenile MyositisRecrutando

NCT05895786 · A Study to Understand How the Study Medicine (PF-06823859) W…Recrutando

NCT07160205 · Safety and Efficacy of ULSC on Disease Severity and Steroid …Recrutando

PHASE2, PHASE3

NCT04402086 · Rheumatology Patient Registry and BiorepositoryRecrutando

NCT07374107 · MIHRA - Patient-Rooted Insights for Shaping Myositis Science…Recrutando

NCT06347718 · CAR-T Cells in Systemic B Cell Mediated Autoimmune DiseaseRecrutando

PHASE1, PHASE2

NCT05979441 · A Study to Assess the Long-term Safety and Efficacy of a Sub…Por convite

NCT05832034 · Add-on Intravenous Immunoglobulins in Early MyositisAtivo

Outros ensaios clínicos

183 ensaios clínicos encontrados, 12 ativos.

Distribuição por fase

PHASE2, PHASE3

NCT01734369 · Environmental Risk Factors for Myositis in Military Personne…Concluído

NCT01432613 · Diagnostic Accuracy of Whole Body Magnetic Resonance Imaging…Concluído

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NCT05027152 · Muscle Function and Effects of Repetitive Task Training in P…Concluído

NA

NCT00341679 · Studies of the Natural History and Pathogenesis of Autoimmun…Concluído

NCT01415219 · Efficacy of an Individual Rehabilitation Program in Polymyos…Concluído

NCT07012057 · Study of Deucravacitinib for Refractory Adults With Dermatom…Cancelado

NCT04628936 · Open-label Extension to the Phase 2 Crossover Study (PRESIDI…Concluído

NCT04033926 · A Phase 2 Study of KZR-616 to Evaluate Safety and Efficacy i…Concluído

Ver todos no ClinicalTrials.gov

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Timeline de publicações

2.006 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 2.006

#1

[Expression of the melanoma 2-mediated pyroptosis pathway in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences2026 Feb 18

To detect the expression levels of absence in melanoma 2 (AIM2), cysteine aspartate-specific protease-1 (caspase-1), and gasdermin D (GSDMD) in peripheral blood mononuclear cell (PBMC) of patients with idiopathic inflammatory myopathy (IIM) and to explore their role in the pathogenesis of IIM. A total of 30 IIM patients (IIM group) who visited the Department of Rheumatology and Immunology, General Hospital of Northern Theater Command from May 2020 to June 2022 were recruited. Concurrently, 30 healthy volunteers matched by gender and age were recruited from the hospital's Health Examination Center. Clinical information, biochemical and immunological mar-kers, and venous blood samples were collected from the study subjects. Serum double-stranded DNA (dsDNA) levels were detected by fluorescence quantitative method, and the mRNA expression levels of AIM2, caspase-1, GSDMD, interleukin 1β (IL-1β), and IL-18 in PBMC were detected by reverse transcription quantitative real-time PCR (RT-qPCR). The protein expression levels of AIM2, caspase-1, GSDMD, IL-1β, and IL-18 in PBMC were detected using the Western blot (WB) method, and the serum levels of IL-1β and IL-18 were detected by enzyme-linked immunosorbent assay (ELISA). The IIM group included 10 cases of dermatomyositis (DM), 5 cases of polymyositis (PM), 11 cases of overlap syndrome (OM), and 4 cases of immune-mediated necrotizing myopathy (IMNM). Compared with the healthy control group, the serum levels of dsDNA, IL-1β, and IL-18 were significantly increased in the IIM group and its subgroups (P < 0.05). Except for the fact that there was no statistically significant difference in AIM2 mRNA levels in PBMC of the IMNM subgroup compared to the healthy control group, the expression of AIM2, caspase-1, and GSDMD mRNA was significantly increased in the IIM group and other subgroups (P < 0.05); Except for the comparison of IL-1β mRNA levels in PBMC of the IMNM and OM subgroups with the healthy control group showing no statistical difference, the expression of IL-1β and IL-18 mRNA was significantly increased in the IIM group and other subgroups (P < 0.05); Comparisons between subgroups indicated that the expression of IL-1β mRNA in the DM subgroup was significantly higher than that in the OM and IMNM subgroups, and the expression of IL-18 mRNA in the PM subgroup was significantly higher than that in the DM and OM subgroups (P < 0.05). The expression levels of AIM2, caspase-1, GSDMD, IL-1β, and IL-18 proteins in PBMC of the IIM group and its subgroups were significantly higher than those in the healthy control group (P < 0.05); Comparisons among subgroups revealed that the expression of IL-18 protein in the OM subgroup was significantly higher than that in the PM subgroup (P < 0.05). In the IIM group, the mRNA of caspase-1, GSDMD, and IL-18 showed a positive correlation with AIM2 mRNA, and the protein expression of caspase-1, GSDMD, IL-1β, and IL-18 also showed a positive correlation with AIM2 protein expression. The AIM2 inflammasome-mediated pyroptosis pathway may be involved in the pathogenesis of IIM, providing a theoretical basis for further research on the etiology of IIM and the development of new therapies. 检测特发性炎性肌病(idiopathic inflammatory myopathy，IIM)患者外周血单个核细胞(peripheral blood mononuclear cell，PBMC)中黑色素瘤缺失因子2(absent in melanoma 2，AIM2)及其介导的细胞焦亡通路关键组分——半胱氨酸天冬氨酸蛋白酶1(cysteine aspartate-specific protease-1，caspase-1)和焦孔素蛋白D(gasdermin D，GSDMD)的表达，并探讨其在IIM发病机制中的作用。招募2020年5月至2022年6月于中国人民解放军北部战区总医院风湿免疫科就诊的30例IIM患者(IIM组)，同期于医院体检中心招募30名性别和年龄与IIM患者相匹配的健康志愿者(健康对照组)，收集研究对象临床信息、血液生化和免疫标志物，以及静脉血样本。通过荧光定量法检测血清双链DNA(double-stranded DNA，dsDNA)水平，通过实时荧光定量逆转录PCR(reverse transcription quantitative real-time PCR，RT-qPCR)检测PBMC中AIM2、caspase-1、GSDMD、白细胞介素1β(interleukin 1β，IL-1β)和IL-18的mRNA表达水平，应用蛋白免疫印迹法检测PBMC中AIM2、caspase-1、GSDMD、IL-1β和IL-18的蛋白表达水平，应用酶联免疫吸附(enzyme-linked immuno-sorbent assay，ELISA)法检测血清中IL-1β和IL-18的表达水平。 IIM组包含皮肌炎(dermatomyositis，DM，n=10)、多发性肌炎(polymyositis，PM，n=5)、重叠性肌炎(overlap syndrome，OM，n=11)和免疫介导的坏死性肌病(immune-mediated necrotizing myopathy，IMNM，n=4)4个亚组。与健康对照组相比，IIM组及其各亚组的血清中dsDNA、IL-1β和IL-18水平均显著增加(P＜0.05)。除IMNM亚组PBMC中AIM2 mRNA与健康对照组差异无统计学意义外，IIM组及其他亚组AIM2、caspase-1和GSDMD mRNA表达均显著增加(P＜0.05)；除IMNM和OM亚组PBMC中IL-1β mRNA与健康对照组比较差异无统计学意义外，IIM组及其他亚组IL-1β和IL-18 mRNA表达均显著增加(P＜0.05)；亚组间比较表明，DM亚组PBMC中IL-1β mRNA表达明显高于OM和IMNM亚组，PM亚组IL-18 mRNA表达明显高于DM和OM亚组(P＜0.05)。IIM及其各亚组的PBMC中，AIM2、caspase-1、GSDMD、IL-1β和IL-18蛋白的表达水平均显著高于健康对照组(P＜0.05)；各亚组间比较发现，OM亚组的IL-18蛋白表达显著高于PM亚组(P＜0.05)。相关性分析表明，IIM组caspase-1、GSDMD和IL-18 mRNA与AIM2 mRNA呈正相关，caspase-1、GSDMD、IL-1β和IL-18蛋白与AIM2蛋白表达也呈正相关。 AIM2炎性小体介导的细胞焦亡通路可能参与IIM的发病机制，这一结论可以为研究IIM的病因及开发新的治疗方法提供理论基础。

#2

Immunotherapies in autoimmune inflammatory myopathies: Rationale and therapeutic updates.

Handbook of clinical neurology2026

Autoimmune inflammatory myopathies (AIM) constitute a heterogeneous group of acquired myopathies with endomysial inflammation as a shared feature highlighting a potentially autoimmune inflammatory process amenable to immunotherapies. The disorders can be best classified as dermatomyositis, necrotizing autoimmune myositis, antisynthetase syndrome-overlap myositis, and inclusion body myositis. Because of clinical and immunohistologic heterogeneity but often overlapping pathophysiologic features among all major subsets, a correct diagnosis is critical from the outset to apply the most suitable and subset-specific immunotherapy. Advances in the immunopathologic characterization of autoimmune inflammatory myopathies have identified potentially mechanism-specific disease subsets that promise the application of targeted immunotherapies for better clinical outcomes. A number of recent clinical trials with biologic agents and monoclonal antibodies, regardless of the clinical outcome considering that several were negative, have collectively expanded our knowledge on the main pathogenic markers of autoimmunity associated with each AIM subset including the role of T-cell or B-cell factors, key cytokines, complement and various associated antibodies, or innate immunity factors. The paper summarizes the main clinical and histopathologic features of each myositis subtype, including overlapping or unique concepts of their immunopathogenic mechanisms, being mainly focused on applied immunotherapies and relevant controlled clinical trials discussing evidence-based efficacy according to the currently evolved therapeutic algorithm. The ongoing trials are also discussed highlighting those with promising future, if applied early in the disease, and the new immunotherapeutic interventions for the refractory AIM subsets.

#3

CTRP1 regulates skeletal muscle differentiation through quality control of mitochondrial dynamics and function.

Molecular therapy : the journal of the American Society of Gene Therapy2026 Jan 02

Mitochondrial dysfunction is a hallmark of myopathies and impaired skeletal muscle differentiation. Here, we demonstrate that C1q/TNF-related protein 1 (CTRP1) is essential for maintaining mitochondrial dynamics and supporting myogenic differentiation. Loss of CTRP1 in myoblasts and in skeletal muscle-specific-knockout (CTRP1 KOΔACTA) mice led to impaired myotube formation, reduced muscle fiber cross-sectional area, and decreased muscle strength. CTRP1 deficiency also shifted the muscle fiber composition from oxidative type IIA to glycolytic type IIB fibers, indicating a compromised mitochondrial capacity. At the cellular level, CTRP1 loss resulted in elongated and disorganized mitochondria with diminished cristae density, membrane potential, and oxidative respiration. These mitochondrial abnormalities are associated with defective recruitment of dynamin-related protein 1 (DRP1), a central mediator of mitochondrial fission. Restoring CTRP1 expression or performing mitochondrial transplantation in CTRP1-KO myoblasts rescued mitochondrial function and re-established differentiation capacity. Furthermore, CTRP1 expression progressively decreased in accordance with disease severity in skeletal muscle biopsies from patients with polymyositis, dermatomyositis, and Duchenne muscular dystrophy, supporting its potential relevance to human myopathies. Together, these findings identify CTRP1 as a novel regulator of mitochondrial quality and myogenic differentiation, highlighting its potential as a therapeutic target for mitochondrial myopathies.

#4

Genetic Association Between Polymyositis/Dermatomyositis and Epilepsy: Insights From Mendelian Randomization and Bioinformatic Analyses.

Brain and behavior2026 Jan

Idiopathic inflammatory myositis (IIM), comprising polymyositis (PM) and dermatomyositis (DM), is a collective term for immune-mediated diseases characterized by skeletal muscle inflammation. Emerging evidence points to an increased incidence of epilepsy in patients with PM/DM. However, the causality and underlying mechanisms behind this association are unclear. Our study aimed to explore the potential causal link between PM/DM and epilepsy, with a focus on immune-mediated mechanisms, using Mendelian randomization (MR) and transcriptome analyses. Initially, summary data from genome-wide association studies (GWAS) related to polymyositis (PM; finn-b-M13_POLYMYO), dermatomyositis (DM; finn-b-DERMATOPOLY_FG), and epilepsy (ebi-a-GCST90018840) were obtained from the Integrative Epidemiology Unit Open GWAS database. These data were utilized for Mendelian randomization (MR) analysis and generalized summary data based Mendelian randomization (GSMR). To ensure the robustness of the findings, sensitivity analyses were conducted to corroborate the results of the MR analyses. Subsequently, the study leveraged publicly accessible databases and bioinformatics tools to conduct comprehensive analyses of gene expression data. This included differential expression analysis, immune infiltration analysis, and gene enrichment analysis. Differentially expressed SNP-related genes (DE-SRGs) were further analyzed using single-cell transcriptomics. Finally, the expression of four key genes (IER3, TNF, GPANK1, and ATF6B) in the hippocampus of epilepsy mouse model was quantified using PCR. The MR analysis disclosed a causal association between PM and epilepsy, whereas the reverse MR analysis did not identify a significant causal effect of epilepsy on PM. However, there was no association between DM and epilepsy of MR analysis. The Transcriptome analysis not only identified DE-SRGs but also revealed distinct immune cell infiltration patterns in epilepsy patients. Specifically, we observed SRGs are mainly expressed in endothelial cells, microglia, and T cells, indicative of a proinflammatory state. Furthermore, the gene set variation analysis (GSVA) highlighted the differential activation of pathways in these cell types, including inflammatory response and allograft rejection, which were significantly upregulated. PCR results show the expression of IER3, TNF, GPANK1, and ATF6B in hippocampus of epilepsy model largely consistent with bioinformatics predictions. The study reveals a causal association between PM and epilepsy, with no significant impact of epilepsy on PM. There is no causal association between DM and epilepsy. The absence of a DM-epilepsy link may reflect fundamental differences in immunopathology: while PM is driven by T cell-mediated muscle invasion, DM involves predominant humoral immunity and complement deposition, suggesting distinct neuroinflammatory implications. Our findings establish immune-mediated neuroinflammation as the central mechanistic link between PM and epileptogenesis. These findings implicate shared immunopathogenic mechanisms and suggest therapeutic targets for epilepsy associated with polymyositis.

#5

Adverse pregnancy outcomes in adult patients with idiopathic inflammatory myopathy: a systematic review and meta-analysis.

Arthritis care & research2026 Mar 23

Studies of the impact of idiopathic inflammatory myopathy (IIM) and its pregnancy complications have yielded controversial results. The purpose of this study was to perform a systematic literature review and meta-analysis to evaluate the association between IIM and adverse pregnancy outcomes. PubMed, Embase, and Web of Science databases were searched to identify reports of interest. The databases were searched from establishment to May 15, 2025.Two investigators independently screened literature and extracted data according to inclusion and exclusion criteria. Newcastle-Ottawa Scale was used for quality assessment. A random effects model with inverse-variance weighting was selected to estimate the pooled odds ratio (OR) and 95% confidence interval (CI). Data analysis was carried out using RevMan 5.3. This analysis included five population-based retrospective cohorts, predominantly comprising patients with dermatomyositis or polymyositis; thus, the pooled estimates primarily reflect these subtypes. Compared to non-IIM pregnant women, IIM patients had significantly higher risks of hypertensive disorders of pregnancy (OR: 2.73, 95% CI: 1.76-4.23; I2=70%, Q P=0.01; overall effect P<0.00001) and cesarean section (OR: 2.03, 95% CI: 1.37-3.00; I2=79%, Q P=0.002; overall effect P=0.004). Infants born to IIM mothers also had notably higher rates of preterm birth (OR: 3.71, 95% CI: 2.35-5.85; I2=60%, Q P=0.06; overall effect P<0.00001) and small for gestational age/intrauterine growth restriction (OR: 1.90, 95% CI: 1.03-3.51; I2=43%, Q P=0.15; overall effect P=0.04). Our meta-analysis showed IIM to be associated with increased risk of hypertensive disorders of pregnancy, caesarean section, preterm birth and small for gestational age/intrauterine growth restriction birth, though residual confounding by disease activity and treatment may contribute.

Publicações recentes

Association between IL1B rs16944 polymorphism and the risk of idiopathic inflammatory myopathies.

📖 Revisão

Front Immunol2026

Quantitative spectral computed tomography biomarkers for idiopathic inflammatory myopathy-associated interstitial lung disease: a dual-layer detector computed tomography study.

Quant Imaging Med Surg2026 Apr 1

Anti-polymyositis/scleroderma antibody-positive myositis exhibits greater cutaneous T cell activation than anti-ARS antibody-positive myositis.

JAAD Int2026 Apr

Clinical characteristics and factors associated with dysphagia in idiopathic inflammatory myopathy: A cross-sectional observational study.

Med Clin (Barc)2026 Apr 6

Maternal and fetal outcomes in pregnancies affected by mixed connective tissue disease.

Obstet Med2026 Apr 1

Ver todas no PubMed

📚 EuropePMC3.208 artigos no totalmostrando 198

Arthritis care & research

Adverse pregnancy outcomes in adult patients with idiopathic inflammatory myopathy: a systematic review and meta-analysis.

Advanced biomedical research

Clinical Findings, Antibody Panel and Pathology of Patients with Inflammatory Myopathies in Isfahan Province, Iran.

Prevalence and Risk of Falls and Fractures in the Idiopathic Inflammatory Myopathies: A Cross-Sectional Study of 470 Patients.

Rheumatology and therapy

The Myositis Overlap Conundrum: Differentiating Polymyositis from Inclusion Body Myositis.

Juntendo medical journal

Journal of neuromuscular diseases

Semi-quantitative analyses of muscle magnetic resonance imaging for pattern recognition in early idiopathic inflammatory myopathies.

The American journal of case reports

Fatal Cardiomyopathy Secondary to Seronegative Immune-Mediated Necrotizing Myopathy: A Case Report.

Pain practice : the official journal of World Institute of Pain

Symptomatic Spontaneous Intracranial Hypotension Caused by a Cerebrospinal Fluid Leak at the C1-C2 Level of the Spine Sealed With an Epidural Blood Patch-Case Series and Review of Literature.

Anti-PM/Scl Antibody-Positive Dermatomyositis With Rapidly Progressive Interstitial Lung Disease in a 19-Year-Old Male: Clinical Implications of a Presumptive Diagnosis Based on Line Immunoassay Positivity.

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova

[Diagnosis of myasthenia gravis in a patient with polymyositis].

Journal of neuroimmunology

Rethinking rituximab in neuroimmunology: Real-world efficacy, cost-effectiveness, and long-term remission.

Clinical and experimental rheumatology

Fitbit as an activity monitor in idiopathic inflammatory myopathy: results from a real-world cohort.

Respiratory medicine case reports

Pleuroparenchymal fibroelastosis associated with anti-Ku antibody-positive polymyositis: A case report with prominent systemic muscle atrophy and review of five cases.

Development and validation of a multi-institutional electronic juvenile idiopathic arthritis phenotype.

Association between Oropharyngeal Dysphagia and Subgroups of Patients with Idiopathic Inflammatory Myopathy: A Cross-Sectional Study.

Dysphagia

Elevated serum interleukin-38 levels in polymyositis and dermatomyositis: diagnostic implications and correlations with inflammatory markers.

[Macrophage activation syndrome in a young patient with polymyositis].

Ugeskrift for laeger

Prognostic value of HRCT-based risk stratification for acute/subacute progression in polymyositis/dermatomyositis-associated interstitial lung disease.

Multicentre development and validation of data-driven claims-based algorithms for identifying dermatomyositis and polymyositis in Japan.

Modern rheumatology

Acta neuropathologica communications

Proteomic profiles in inclusion body myositis and polymyositis with mitochondrial pathology.

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

[Expression of the melanoma 2-mediated pyroptosis pathway in peripheral blood mononuclear cells of patients with idiopathic inflammatory myopathies].

Idiopathic Inflammatory Myopathy With Normal Creatine Kinase Levels in an Elderly Patient: A Diagnostic Challenge.

Acute Hypoxemic Respiratory Failure Caused by Nonspecific Interstitial Pneumonia in Mixed Connective Tissue Disease: A Case Report.

Serum interferon-λ3 as a short-term biomarker of disease control in anti-MDA5-positive dermatomyositis-associated ILD.

Scientific reports

Journal of cosmetic dermatology

Dermatomyositis and Polymyositis: Are Both Ends of a Same Spectrum?

Handbook of clinical neurology

Immunotherapies in autoimmune inflammatory myopathies: Rationale and therapeutic updates.

Initial presentation with elevated transaminases and subsequent hematuria in limb-girdle muscular dystrophy type 2B: A case report.

Cancer management and research

Rhabdomyolysis as a Predominant Multisystem Serious Immune-Related Adverse Event Induced by Sintilimab: A Case Report and Literature Review.

Pregnancy outcomes in idiopathic inflammatory myopathies: a Portuguese multicentre study.

Frontiers in medicine

Association of autoimmune diseases with chronic rhinosinusitis in general practices in Germany.

Rhinology

Molecular therapy : the journal of the American Society of Gene Therapy

CTRP1 regulates skeletal muscle differentiation through quality control of mitochondrial dynamics and function.

International immunopharmacology

Baricitinib alleviates myositis-associated interstitial lung disease in mice by inhibiting the NETs-cGAS-STING-EMT axis.

Therapeutic advances in neurological disorders

Shaping the role of plasma exchange in autoimmune neurology: lessons learned from 67 years and over 90,000 procedures.

Genetic Association Between Polymyositis/Dermatomyositis and Epilepsy: Insights From Mendelian Randomization and Bioinformatic Analyses.

Brain and behavior

Toxoplasma gondii infection inhibits myotube formation in a 3D model of chicken muscle cell culture.

BMC microbiology

Unraveling the genetic association between autoimmune thyroid diseases and idiopathic inflammatory myopathies in the European population.

Sit to stand and timed up and go in idiopathic inflammatory myopathies.

Scientific reports

A Comparative Bibliometric Analysis of Pediatric Interstitial Lung Disease Treatment: Global Trends, Advances, and Future Directions (2004-2024).

Pediatric pulmonology

Quintessence international (Berlin, Germany : 1985)

Trigeminal neuropathy as the first symptom of mixed connective tissue disease: case report and literature review.

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences

[Clinical characteristics, efficacy and safety of antifibrotic agents in elderly patients with connective tissue disease-associated interstitial lung disease].

Modern rheumatology case reports

Anti-SRP antibody-positive polymyositis complicated by neuromyelitis optica spectrum disorder: a case report and literature review.

Journal of clinical medicine

CaNO and eCO Might Be Potential Non-Invasive Biomarkers for Disease Severity and Exacerbations in Interstitial Lung Disease.

Rapidly Progressive Polymyositis With Vasculitis: The Pivotal Role of Histopathology in Diagnosis and Management.

World journal of clinical cases

Mixed connective tissue disease and tuberculosis coexistence as a diagnostic dilemma: A case report.

Rheumatology international

Dermatomyositis and microscopic polyangiitis overlap: a case-based review.

Factors associated with interstitial lung disease among patients with idiopathic inflammatory myopathies.

Let's talk about pain, the new important domain to assess and address in adult myositis-a qualitative study: a MIHRA collaboration.

Intravenous immunoglobulin is an effective steroid-sparing drug in inflammatory myositis.

Danish medical journal

Medicina (Kaunas, Lithuania)

Malignancy Risk and Predictors in Dermatomyositis and Polymyositis: A Large Population-Based Study.

In utero and early life exposures to smoking are associated with systemic autoimmune rheumatic diseases.

Overall and by subtype epidemiology of idiopathic inflammatory myopathies among African descent patients with free access to high standard healthcare.

Journal of visualized experiments : JoVE

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy.

[Frequency of hypogonadism and clinical features of systemic sclerosis and idiopathic inflammatory myopathies in men depending on testosterone levels].

Terapevticheskii arkhiv

Arthritis research & therapy

Revisiting the link between oropharyngeal dysphagia and cancer in autoimmune myositis: a descriptive study.

Nailfold videocapillaroscopy abnormalities in autoimmune inflammatory myopathy subsets.

Statin-Associated Immune-Mediated Necrotizing Myopathy With Dual Anti-3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase (Anti-HMGCR) and Anti-OJ Positivity: A Case Report of Fulminant Weakness and Respiratory Failure.

Rheumatic diseases clinics of North America

The Mythology of Polymyositis.

Epidemiology of Dermatomyositis and Other Idiopathic Inflammatory Myopathies in Northern Spain.

Biomedicines

Identification of a distinctive gene signature associated with disease activity in granulomatous myositis.

Unveiling IL-41: A novel biomarker for polymyositis and dermatomyositis diagnosis.

Cytokine

A population-based prevalence of adults with dermatomyositis and polymyositis in Colombia: a bayesian approach.

BMC rheumatology

Risk stratification of acute exacerbations by autoantibodies in patients with idiopathic interstitial pneumonia.

Scientific reports

Predictive models for non-response to conventional treatment in polymyositis and dermatomyositis.

Frontiers in medicine

Inflammation and regeneration

Recent advances in immunological mechanisms and murine disease models of idiopathic inflammatory myopathies.

Presence of Myositis-Specific Autoantibodies May Predict Favorable Outcomes to Rituximab in Patients with Idiopathic Inflammatory Myositis: Retrospective Observational Study.

Modern rheumatology

International journal of rheumatic diseases

Circulating Galectins and Risk of Dermatopolymyositis: A Mendelian Randomization Study.

Annals of the rheumatic diseases

Enhanced proteasome activity in perifascicular myofibres is a hallmark of dermatomyositis and its inhibition is efficient in preclinical models.

Proceedings of the National Academy of Sciences of the United States of America

Autoimmunity-associated DIORA1 binds the MRCK family of serine/threonine kinases and controls cell motility.

Continuum (Minneapolis, Minn.)

Idiopathic Inflammatory Myopathies.

BioMed research international

Anti-AHNAK1 Antibodies Are a Novel Diagnostic Biomarker for Systemic Lupus Erythematosus.

Identification of idiopathic inflammatory myopathy research cohorts using international classification of disease (ICD) codes: A systematic review.

Idiopathic inflammatory myopathy associated with Sjögren's disease: features of a distinct clinical entity.

Orbital myositis: an uncommon ophthalmic presentation in scleroderma-polymyositis overlap syndrome.

BMJ case reports

Epidemiologia (Basel, Switzerland)

The Prevalence of Various Autoimmune Comorbidities in Patients with Inflammatory Bowel Disease.

The comparison of deep learning and radiomics in the prediction of polymyositis.

Long-term oral glucocorticoid use is associated with complications, healthcare resource utilization, and costs among patients with dermatomyositis or polymyositis.

Diagnostic efficacy of serum Krebs von den Lungen-6 for dermatomyositis/polymyositis-associated interstitial lung diseases: A systematic review and meta-analysis.

Clinical medicine insights. Arthritis and musculoskeletal disorders

Overlapping Connective Tissue Disease-Polymyositis and Diffuse Systemic Scleroderma: A Case Report.

[Pathomorphological characteristics of inflammatory and hereditary myopathies].

Arkhiv patologii

A possible role for immunogenetic factors in myositis developing after vaccination in the pre-covid-19 era.

Rheumatology international

Small extracellular vesicle cargo as biomarkers in autoimmune rheumatic diseases: a systematic review.

Recurrence of Anti-melanoma Differentiation-Associated Gene 5 Antibody-Positive Dermatomyositis Following Long-Term Remission: A Report of Two Cases and Review of Literature.

A retrospective natural history study in adult and juvenile patients with incident dermatomyositis and polymyositis using real world data.

Shared genetic susceptibility between idiopathic inflammatory myopathies and common B cell lymphoma subtypes found primarily in the human leucocyte antigen region.

Zeitschrift fur Rheumatologie

[Not just frailty-Sjögren's syndrome and polymyositis with mitochondrial pathology].

PLoS neglected tropical diseases

Prevalence of human T-cell leukemia virus type 1 associated inflammatory myopathies (HAIM) in Salvador, Brazil.

Polymyositis Masking Statin-Induced Necrotizing Autoimmune Myopathy: A Teachable Moment.

JAMA internal medicine

The Journal of rheumatology

Utilization of Rehabilitation Services After Idiopathic Inflammatory Myopathy Diagnosis: A Retrospective Cohort Assessment in the United States.

Posterior Reversible Encephalopathy Syndrome: A Case Report With Contemporary Literature Review and Neuropathological Evidence From Autopsy.

Dermatology practical & conceptual

Atopic Dermatitis and Autoimmune Connective Tissue Diseases: Systematic Review and Meta-Analysis.

Clinical and experimental medicine

Polymyositis-like hypothyroid myopathy: diagnostic challenges and therapeutic outcomes in a case series.

The Cochrane database of systematic reviews

Non-targeted immunosuppressive and immunomodulatory therapies for idiopathic inflammatory myopathies.

A shared monocyte cytokine signature induced by serum from patients with systemic lupus erythematosus and anti-MDA5 antibody-positive dermatomyositis through the type I interferon pathway.

Immunology letters

Paraneoplastic Inflammatory Myositis False-positive for Anti-aminoacyl-tRNA synthetase Antibody Successfully Ameliorated by Immunosuppressive Therapy.

The Cochrane database of systematic reviews

Targeted immunosuppressive and immunomodulatory therapies for idiopathic inflammatory myopathies.

International journal of genomics

Whole Exome Sequencing Identified a Stop-Gained Mutation in DYSF Gene Associated With Dysferlinopathy in an Iranian Family.

Journal of human genetics

Genetics of myositis - distinct backgrounds of subtypes.

Rheumatological Manifestations in People Living with Human T-Lymphotropic Viruses 1 and 2 (HTLV-1 and HTLV-2) in Northern Brazil.

Viruses

Current issues in molecular biology

IFN-γ +874 T/A Is Associated with High Levels of Sera CPK in Patients with Inflammatory Myopathies.

Life (Basel, Switzerland)

Beyond Comorbidity: Pulmonary Adenocarcinoma in a Patient with Rheumatoid Arthritis-A Case Report and Literature Review.

Current allergy and asthma reports

CD8+ T Cells You Should Know about in Autoimmunity: Current Paradigms of T Cell Pathogenesis in Autoimmune Disease.

Religiosity, Spirituality, and Fatigue in Patients With Idiopathic Inflammatory Myopathies: A Brazilian Multicentric Case-Control Study.

Exploring vaccine safety and adverse events in major autoimmune diseases.

Autoimmunity reviews

The Association Between Autoimmune Rheumatic Diseases and Depression: A Two-Sample Bidirectional Mendelian Randomization.

Psychiatry

Dasatinib-Induced Polymyositis-Like Syndrome: A Report of a Rare Case.

Adolescent late-onset riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency manifesting with severe multi-organ failure: a case report.

Frontiers in pediatrics

Subclinical Myocardial Involvement Evaluated by Cardiac Magnetic Resonance Imaging in a Patient with Anti-Ro52/SS-A Antibody-positive Sjögren's Disease Complicated with Polymyositis.

Remission and low disease activity definitions in adult idiopathic inflammatory myopathies: A narrative review by myositis clinical trials consortium (MCTC).

Autoimmunity reviews

NXP-2-positive polymyositis associated with scrub typhus.

BMJ case reports

A Case of Anti-TIF1γ Antibody-Positive Dermatomyositis Associated With Malignancy.

Journal of investigative medicine high impact case reports

Polymyositis-Induced Atrial Flutter: A Rare and Unexpected Arrhythmia in an Idiopathic Inflammatory Myopathy.

Journal of the American Academy of Dermatology

The Prospective Registry Of MyositIS (PROMIS): II. Temporal shifts in causes of death among patients with idiopathic inflammatory myopathies.

Clinical impact of pneumomediastinum in patients with myositis-associated interstitial lung disease.

PloS one

Current rheumatology reviews

Case Report of an Atypical Presentation of Inclusion Body Myositis Masquerading as Polymyalgia Rheumatica.

Risk Factors Associated With Thrombocytopenia Induced by Intravenous Immunoglobulin Formulations: An Analysis Using the JADER database.

In vivo (Athens, Greece)

The Journal of clinical and aesthetic dermatology

Refractory Acrodermatitis Continua of Hallopeau in a Pediatric Patient: Unveiling Underlying Mixed Connective Tissue Disorder.

Mitochondrial pathology in inflammatory myopathies: a marker of worse clinical outcome.

Journal of neurology

medRxiv : the preprint server for health sciences

Identification of a distinctive gene signature in granulomatous myositis.

Rehospitalization to evaluate outcomes during clinical courses in patients with elderly-onset idiopathic inflammatory myositis: a retrospective single-center study.

Clinical and experimental rheumatology

Infections preceding diagnosis associated with myositis phenotypes in a national patient registry.

Journal of pediatric endocrinology & metabolism : JPEM

Transient worsening of thyrotoxic myopathy following methimazole and metoprolol initiation in a 12-year-old girl: a case report and literature review.

Frontiers in veterinary science

Age of onset, treatment response, and survival rates in Dutch Kooiker dogs diagnosed with hereditary polymyositis.

Diagnostic significance of carcinoembryonic antigen and anti-MDA5 antibodies in polymyositis/dermatomyositis-associated rapidly progressive interstitial lung disease.

Medicina clinica

Myositis Due to Parvovirus B19: A Case Report and Literature Review.

Kidney international reports

Persistent B Cell Depletion After Rituximab for Autoimmune and Glomerular Diseases: A Case Series.

Journal of cardiology cases

Mixed shock after alcohol septal ablation for hypertrophic obstructive cardiomyopathy: Impella in crisis management.

Respiratory medicine and research

Anti-Mi-2 positive interstitial lung disease (ILD): A progressive disease comparable to other myositis-ILD.

Psoriasis complicated with polymyositis successfully treated with Ixekizumab: A case report.

Epidemiology and risk of psychiatric disorders in patients with polymyositis and dermatomyositis: a nationwide population-based cohort study in Taiwan.

BMJ open

Polymyositis Presenting With Respiratory Failure and Cardiac Arrest: A Case Report.

Application of Quantitative CT and Machine Learning in the Evaluation and Diagnosis of Polymyositis/Dermatomyositis-Associated Interstitial Lung Disease.

Academic radiology

TIGIT deficiency promotes autoreactive CD4+ T-cell responses through a metabolic‒epigenetic mechanism in autoimmune myositis.

Nature communications

Best practice & research. Clinical rheumatology

Rheumatic manifestations of HIV/AIDS.

Differences in Organ Damage Based on Age at Onset in Idiopathic Inflammatory Myopathies: A Retrospective Multicenter MYKO Study.

Italian journal of pediatrics

Comprehensive analysis of acute flaccid paralysis with and without myelitis in Taiwanese children.

Immunity, inflammation and disease

Clinical Progress in Mesenchymal Stem Cell Therapy: A Focus on Rheumatic Diseases.

Laryngeal involvement in relapsing polychondritis: clinical and CT findings in 173 patients.

Long-term outcomes of idiopathic inflammatory myopathies: a large-scale longitudinal cohort study.

Journal of autoimmunity

Fatigue is common in myositis and is associated with disease activity.

Dysphagia During Pharyngeal and Esophageal Phase of Seronegative Immune-Mediated Necrotizing Myopathy: A Case Report.

Lung involvement is a risk factor for treatment resistance in patients with polymyositis and dermatomyositis.

Archives of rheumatology

Autophagy in myositis, a dysregulated pathway, and a target for therapy.

Autoimmunity reviews

Respiratory medicine and research

Progressive course of anti-nuclear matrix protein-2 (NXP-2) positive-interstitial lung disease.

Journal of the American Veterinary Medical Association

Severe neuromuscular weakness in a 7-year-old domestic shorthair cat.

Journal of clinical medicine

Prevalence of Elevated CK Levels, Myositis-Specific and Myositis-Associated Antibodies, Myositis, and Other Neuromuscular Diseases in Myasthenia Gravis Patients-Experience from an Eastern European Tertiary Center.

CD73low B-cell phenotypes and distinct cytokine profiles in patients with active anti-Jo-1 antibody positive idiopathic inflammatory myopathies.

Polymorphisms of HSP70 genes are involved in the pathogenesis of idiopathic inflammatory myopathy.

Reumatologia

A comparative study of different types of connective tissue-associated interstitial lung disease.

BMC medical imaging

Brain : a journal of neurology

Mitochondrial damage is associated with an early immune response in inclusion body myositis.

Real-life effectiveness of rituximab in different subsets of idiopathic inflammatory myopathies.

Reumatismo

Idiopathic Interstitial Lung Disease with Positive Anti-Zo and Anti-Ro52/SSA1 Antibodies.

Muscle Function, Muscle Disease, and Positron Emission Tomography-Computed Tomography: A Narrative Review.

Pulse corticosteroid therapy in interstitial lung disease-associated with anti-aminoacyl-tRNA synthetase antibodies: Comparable efficacy with potential for reduced adverse events.

Respiratory medicine

The Journal of dermatology

Persistent exanthema mainly on the trunk with pathologically dermal interstitial mucin as anti-HMGCR myopathy-associated skin rash: Case series.

Converging Inflammations: Simultaneous Myositis and Polyneuropathy as a Diagnostic Challenge.

Medicina (Kaunas, Lithuania)

Paraneoplastic Syndromes in Gallbladder Cancer: A Systematic Review.

Molecular genetics and metabolism reports

Carbamoyl phosphate synthetase 1 deficiency manifested in an adult treated with prednisone for polymyositis, and cured by live-donor liver transplantation.

Development of a new high-yield integration site assay reveals disease-specific patterns across HTLV-1-associated pathologies.

Microbiology spectrum

Journal of inflammation research

Cardiac Involvement in Idiopathic Inflammatory Myopathies.

Journal of clinical medicine

Comparison of Chest High-Resolution Computed Tomography Findings in Patients with Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Positive and Antibody-Negative Progressive Pulmonary Fibrosis with Polymyositis/Dermatomyositis.

Cardiovascular events in patients with myositis: results from a French retrospective cohort.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases

Mortality Trends in Polymyositis and Dermatomyositis in Mexico: A General Population-Based Study From 2000 to 2019.

Arthritis research & therapy

Plasma levels of adhesion molecules are elevated in dermatomyositis-interstitial lung disease and associated with low paraoxonase-1 activity.

Intractable & rare diseases research

A novel ETFDH mutation identified in a patient with riboflavin-responsive multiple acyl-CoA dehydrogenase deficiency.

Experimental myositis: an optimised version of C-protein-induced myositis.

Is mixed connective tissue disease (MCTD) a subtype of systemic sclerosis?

Clinical and experimental rheumatology

Infections as a predominant cause of death in adult patients with idiopathic inflammatory myopathies.

Association between a history of mental illness and the risk of systemic autoimmune rheumatic diseases: a nationwide, population-based case-control study.

Polymyositis-Like Myopathy With Anti-PL-12 Antibody Positivity and Coexisting Antiphospholipid Syndrome: Diagnostic and Management Challenges in the Absence of Systemic Features.

Sub-network transcriptome dataset for diseases associated with exposure to bisphenol F and bisphenol S in human SH-SY5Y neuroblastoma cells.

Data in brief

Serum creatine kinase: requesting and interpreting results.

Practical neurology

Asian Pacific journal of allergy and immunology

Understanding the uncommon: Insights into thymoma associated immunodeficiency.

Advances in rheumatology (London, England)

Patients with anti-PM/Scl-positive and idiopathic inflammatory myopathy resemble anti-synthetase syndrome.

Diagnostics (Basel, Switzerland)

Recognition of Idiopathic Inflammatory Myopathies Underlying Interstitial Lung Diseases.

The utility of muscle magnetic resonance imaging in idiopathic inflammatory myopathies: a scoping review.

Association between Kawasaki disease and subsequent autoimmune disease: National cohort study of adolescents with 12-year follow-up from birth.

Annals of the rheumatic diseases

Precise identification and tracking of HMGCR-reactive CD4+ T cells in the target tissue of patients with anti-HMGCR immune-mediated necrotising myopathy.

Biomedical chromatography : BMC

Metabolomic Analysis of Serum Reveals a Unique Metabolomic Profile in Patients With Myositis and Identified Several Potential Biomarkers in Polymyositis Versus Dermatomyositis Patients.

Annals of the rheumatic diseases

Mitochondrial transplantation as a novel therapeutic approach in idiopathic inflammatory myopathy.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]

A window into intracellular events in myositis through subcellular proteomics.

Respiratory medicine case reports

Pulmonary fibrosis as the sole manifestation of anti-Ku antibody positivity in the absence of myositis: A case report.

Predictive value of myositis antibodies: role of semiquantitative classification and positivity for more than one autoantibody.

Risk of atherosclerosis-related diseases in polymyositis and dermatomyositis patients: A large-scale population-based study.

Atherosclerosis

Inflammation and regeneration

Human PBMC-based humanized mice exhibit myositis features and serve as a drug evaluation model.

Elevated Troponin T (TnT) in Non-acute Coronary Syndrome (ACS) Due to Dermatomyositis.

Arthritis research & therapy

Disease activity in patients with idiopathic inflammatory myopathy according to time since diagnosis and positivity to antisynthetase autoantibodies: data from the Myo-Spain registry.

Clinical nuclear medicine

Disseminated Extranodal Natural Killer/T-Cell Lymphoma Mimicking a Paraneoplastic Polymyositis.

Journal of the American Academy of Dermatology

The spectrum of cutaneous and systemic manifestations associated with anti-PM/Scl: Insights from a single institution case series.

Polymyositis in Kooiker dogs is associated with a 39 kb deletion upstream of the canine IL21/IL2 locus.

PLoS genetics

Acupuncture in medicine : journal of the British Medical Acupuncture Society

Acupuncture for polymyositis: a case report.

Exploring the Genetic Association Between Connective Tissue Diseases and the Risk of Pulmonary Arterial Hypertension: A Mendelian Randomization Analysis.

Pulmonary circulation

Arthritis & rheumatology (Hoboken, N.J.)

Genetic Architecture of Idiopathic Inflammatory Myopathies From Meta-Analyses.

Successful diagnosis and treatment of canine polymyositis: utilizing MRI and immunohistochemistry for accurate detection.

BMC veterinary research

A likely case of chronic graft-versus-host disease polymyositis affecting respiratory and truncal muscles - a comprehensive diagnostic approach.

Blood cell therapy

Surgical treatment of thymic epithelial tumor and myasthenia gravis.

Frontiers in surgery

Journal of Ayub Medical College, Abbottabad : JAMC

OVERLAP AXONAL POLYNEUROPATHY WITH IMMUNE MEDIATED NECROTISING MYOPATHY.

African journal of thoracic and critical care medicine

Pulmonary manifestations of the idiopathic inflammatory myopathies in a South African population.

British journal of hospital medicine (London, England : 2005)

The Association between Rheumatic Diseases and the Risk of Polycystic Ovary Syndrome: A Two-Sample Mendelian Randomization Analysis.