Raras
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Esclerodermia
ORPHA:801CID-10 · M34PCDT · SUSDOENÇA RARA

A esclerodermia é uma doença autoimune rara do tecido conjuntivo caracterizada pelo endurecimento anormal da pele e, às vezes, de outros órgãos. É classificada em duas formas principais: esclerodermia localizada e esclerose sistêmica (ES), esta última compreendendo três subgrupos; ES cutânea difusa (SSc), ES cutânea limitada (SSc) e ES limitada (ESl).

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Introdução

O que você precisa saber de cara

📋

A esclerodermia é uma doença autoimune rara do tecido conjuntivo caracterizada pelo endurecimento anormal da pele e, às vezes, de outros órgãos. É classificada em duas formas principais: esclerodermia localizada e esclerose sistêmica (ES), esta última compreendendo três subgrupos; ES cutânea difusa (SSc), ES cutânea limitada (SSc) e ES limitada (ESl).

Pesquisas ativas
9 ensaios
779 total registrados no ClinicalTrials.gov
Publicações científicas
18.199 artigos
Último publicado: 2026 Mar

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-5 / 10 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
42.0
Worldwide
Início
All ages
🏥
SUS: Cobertura mínimaScore: 30%
PCDT disponívelCID-10: M34
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧬
Pele e cabelo
19 sintomas
🫃
Digestivo
15 sintomas
🦴
Ossos e articulações
12 sintomas
💪
Músculos
8 sintomas
🫁
Pulmão
7 sintomas
❤️
Coração
7 sintomas

+ 63 sintomas em outras categorias

Características mais comuns

Boca estreita
Anormalidade no teste de função pulmonar
Arritmia
Anormalidade da morfologia dos anexos da pele
Anormalidade do sistema cardiovascular
Tireoidite de Hashimoto
157sintomas
Sem dados (157)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 157 características clínicas mais associadas, ordenadas por frequência.

Boca estreitaNarrow mouth
Anormalidade no teste de função pulmonarAbnormality on pulmonary function testing
ArritmiaArrhythmia
Anormalidade da morfologia dos anexos da peleAbnormality of skin adnexa morphology
Anormalidade do sistema cardiovascularAbnormality of the cardiovascular system

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico18.199PubMed
Últimos 10 anos200publicações
Pico2026170 papers
Linha do tempo
2026Hoje · 2026🧪 1986Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

6 genes identificados com associação a esta condição. Padrão de herança: Not applicable.

CCN2CCN family member 2Candidate gene tested inTolerante
FUNÇÃO

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (PubMed:39414788). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis

LOCALIZAÇÃO

Secreted, extracellular space, extracellular matrixSecreted

VIAS BIOLÓGICAS (2)
RUNX3 regulates YAP1-mediated transcriptionYAP1- and WWTR1 (TAZ)-stimulated gene expression
MECANISMO DE DOENÇA

Kyphomelic dysplasia

An autosomal recessive skeletal dysplasia characterized by bowing of the limbs primarily affecting the femora, along with short stature, short and wide iliac wings, horizontal acetabular roof, platyspondyly, metaphyseal flaring and distinctive facial features that include prominent forehead, micrognathia, microstomia, cleft palate and low set ears.

OUTRAS DOENÇAS (4)
kyphomelic dysplasiaspondyloepimetaphyseal dysplasia, Li-Shao-Li typediffuse cutaneous systemic sclerosislimited cutaneous systemic sclerosis
HGNC:2500UniProt:P29279
IRF5Interferon regulatory factor 5Candidate gene tested inTolerante
FUNÇÃO

Transcription factor that plays a critical role in innate immunity by activating expression of type I interferon (IFN) IFNA and INFB and inflammatory cytokines downstream of endolysosomal toll-like receptors TLR7, TLR8 and TLR9 (PubMed:11303025, PubMed:15695821, PubMed:22412986, PubMed:25326418, PubMed:32433612). Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters

LOCALIZAÇÃO

CytoplasmNucleus

VIAS BIOLÓGICAS (3)
Interferon gamma signalingInterferon alpha/beta signalingSLC15A4:TASL-dependent IRF5 activation
MECANISMO DE DOENÇA

Inflammatory bowel disease 14

A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
112.8 TPM
Baço
39.3 TPM
Pulmão
19.5 TPM
Rim - Medula
19.1 TPM
Sangue
18.6 TPM
OUTRAS DOENÇAS (6)
systemic lupus erythematosusprimary biliary cholangitisdiffuse cutaneous systemic sclerosislimited cutaneous systemic sclerosis
HGNC:6120UniProt:Q13568
KIAA0319LDyslexia-associated protein KIAA0319-like proteinCandidate gene tested inRestrito
FUNÇÃO

Possible role in axon guidance through interaction with RTN4R (Microbial infection) Acts as a receptor for adeno-associated virus and is involved in adeno-associated virus infection through endocytosis system

LOCALIZAÇÃO

Cytoplasmic granule membraneGolgi apparatus membraneGolgi apparatus, trans-Golgi network membraneCell membrane

EXPRESSÃO TECIDUAL(Ubíquo)
Pituitária
34.9 TPM
Tireoide
34.7 TPM
Nervo tibial
31.5 TPM
Cérebro - Hemisfério cerebelar
30.8 TPM
Cerebelo
29.9 TPM
INTERAÇÕES PROTEICAS (1)
OUTRAS DOENÇAS (2)
systemic lupus erythematosuslimited cutaneous systemic sclerosis
HGNC:30071UniProt:Q8IZA0
CCR6C-C chemokine receptor-like 2Candidate gene tested inModerado
FUNÇÃO

Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses

LOCALIZAÇÃO

Cell membrane

VIAS BIOLÓGICAS (3)
G alpha (i) signalling eventsChemokine receptors bind chemokinesBeta defensins
OUTRAS DOENÇAS (2)
limited cutaneous systemic sclerosisdiffuse cutaneous systemic sclerosis
HGNC:1607UniProt:O00421
CAV1Caveolin-1Candidate gene tested inTolerante
FUNÇÃO

May act as a scaffolding protein within caveolar membranes (PubMed:11751885). Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its bind

LOCALIZAÇÃO

Golgi apparatus membraneCell membraneMembrane, caveolaMembrane raftGolgi apparatus, trans-Golgi networkCytoplasm

VIAS BIOLÓGICAS (4)
SARS-CoV-2 targets host intracellular signalling and regulatory pathwaysSARS-CoV-1 targets host intracellular signalling and regulatory pathwaysExtra-nuclear estrogen signalingBasigin interactions
MECANISMO DE DOENÇA

Lipodystrophy, congenital generalized, 3

A form of congenital generalized lipodystrophy, a metabolic disorder characterized by a near complete absence of adipose tissue, extreme insulin resistance, hypertriglyceridemia, hepatic steatosis and diabetes mellitus. CGL3 inheritance is autosomal recessive.

OUTRAS DOENÇAS (6)
pulmonary hypertension, primary, 3partial lipodystrophy, congenital cataracts, and neurodegeneration syndromecongenital generalized lipodystrophy type 3heritable pulmonary arterial hypertension
HGNC:1527UniProt:Q03135
HLA-DRB1HLA class II histocompatibility antigen, DRB1 beta chainCandidate gene tested inRestrito
FUNÇÃO

A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells

LOCALIZAÇÃO

Cell membraneEndoplasmic reticulum membraneLysosome membraneLate endosome membraneAutolysosome membrane

VIAS BIOLÓGICAS (7)
Generation of second messenger moleculesTranslocation of ZAP-70 to Immunological synapsePhosphorylation of CD3 and TCR zeta chainsCo-inhibition by PD-1Downstream TCR signaling
EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
1832.6 TPM
Pulmão
1234.8 TPM
Baço
990.6 TPM
Intestino delgado
607.2 TPM
Nervo tibial
598.3 TPM
OUTRAS DOENÇAS (16)
narcolepsy-cataplexy syndromefollicular lymphomaVogt-Koyanagi-Harada diseasepediatric multiple sclerosis
HGNC:4948UniProt:P01911

Variantes genéticas (ClinVar)

57 variantes patogênicas registradas no ClinVar.

🧬 CCN2: NM_001901.4(CCN2):c.779_786del (p.Pro260fs) ()
🧬 CCN2: NM_001901.4(CCN2):c.443G>A (p.Cys148Tyr) ()
🧬 CCN2: NM_001901.4(CCN2):c.65G>C (p.Arg22Pro) ()
🧬 CCN2: NC_000006.11:g.(?_131894423)_(133849943_?)del ()
🧬 CCN2: GRCh37/hg19 6q23.2-24.2(chr6:131569837-145572239)x3 ()
Ver todas no ClinVar

Classificação de variantes (ClinVar)

Distribuição de 1 variantes classificadas pelo ClinVar.

1
Patogênica (100.0%)
VARIANTES MAIS SIGNIFICATIVAS
SLC39A13: NM_001128225.3(SLC39A13):c.398C>T (p.Thr133Met) [Conflicting classifications of pathogenicity]

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado1
3Fase 31
2Fase 23
1Fase 14
·Pré-clínico7
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 16 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Esclerodermia

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

4 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

779 ensaios clínicos encontrados, 9 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
5.825 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 5.825

#1

Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis.

Stem cells translational medicine2026 Mar 23

A esclerose sistêmica juvenil (jSSc) é uma doença autoimune rara e grave em crianças/adolescentes, caracterizada por endurecimento da pele, danos a órgãos e opções terapêuticas subótimas. Diante da limitação dos tratamentos convencionais, este estudo de caso relata uma melhora clínica promissora em um paciente de 17 anos com jSSc refratária após um transplante autólogo de células-tronco. Isso sugere uma potencial nova via de tratamento para casos graves e resistentes.

🇧🇷 traduzido
#2

Automatic assessment of lung involvement in systemic sclerosis using deep learning.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences2026

Este estudo utiliza inteligência artificial (deep learning) para avaliar automaticamente o envolvimento pulmonar em pacientes com esclerodermia sistêmica, aprimorando a precisão diagnóstica em tomografias e minimizando erros humanos. A tecnologia identifica e quantifica as áreas de dano pulmonar, como reticulação e opacidades em vidro fosco, oferecendo aos médicos uma medida objetiva e detalhada da extensão da doença para um acompanhamento e tratamento mais eficazes dos pacientes.

🇧🇷 traduzido
#3

Resting Oxygen Consumption Estimates in Scleroderma Can Lead to Underestimation of Cardiac Output.

Pulmonary circulation2026 Jan

Este estudo alerta que as estimativas padrão do consumo de oxigênio em repouso (rVO2), usadas para calcular a função cardíaca (débito cardíaco) em pacientes com esclerodermia, podem ser imprecisas. Para médicos e pacientes, isso significa que essas estimativas podem levar a uma subestimação do quão bem o coração está bombeando, resultando em diagnósticos errados e impactando o tratamento de problemas cardíacos. A medição direta do rVO2 é, portanto, recomendada para maior precisão diagnóstica.

🇧🇷 traduzido
#4

The Th17/Treg axis: a key to understanding and treating autoimmune disorders.

Open life sciences2026 Jan

Em doenças autoimunes como a esclerodermia, o sistema imunológico ataca o próprio corpo devido a um desequilíbrio entre as células T Th17 (promotoras de inflamação) e as Treg (reguladoras), resultando em inflamação crônica e danos aos tecidos. Compreender e restaurar este balanço é crucial, pois os níveis dessas células podem indicar a gravidade da doença e a eficácia do tratamento, servindo como um alvo terapêutico fundamental para otimizar abordagens clínicas atuais e futuras.

🇧🇷 traduzido
#5

Identification of key macrophage-related genes in systemic sclerosis-associated interstitial lung disease based on single-cell and bulk transcriptomic data.

PloS one2026

Focado na grave doença pulmonar intersticial associada à esclerose sistêmica (SSc-ILD), a principal causa de morte em pacientes com esclerose sistêmica e sem tratamentos eficazes, este estudo identificou os genes **ARG2, ELF3 e NKX2-1** como fatores-chave nos mecanismos relacionados aos macrófagos da doença. Para pacientes e médicos, esses achados são cruciais, pois destacam esses genes como potenciais alvos terapêuticos, com resultados de predição de drogas já sugerindo possíveis interações com medicamentos existentes, o que pode abrir caminho para o desenvolvimento de novas e mais eficazes opções de tratamento.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC9.750 artigos no totalmostrando 198

2026

Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis.

Stem cells translational medicine
2026

Definition, diagnosis, treatment for scleroderma primary heart involvement.

Best practice &amp; research. Clinical rheumatology
2026

A practical clinical approach to the diagnosis and management of morphea (localized scleroderma).

Best practice &amp; research. Clinical rheumatology
2026

Automatic assessment of lung involvement in systemic sclerosis using deep learning.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
2026

Prevalence of comorbidities and medication use in progressive systemic sclerosis in northeast Mexico.

Reumatologia clinica
2026

Implications of Dermatologic Disorders in Facial Cosmetic Surgery: A Systematic Review.

Annals of plastic surgery
2026

Circumscribed Morphea Successfully Treated With Excimer Laser: Analysis of Histopathological Changes.

The Journal of dermatology
2026

Strabismus as the Initial Manifestation of En Coup De Sabre in Adult Patients.

Neuro-ophthalmology (Aeolus Press)
2026

The immune landscape of systemic sclerosis: from pathogenic mechanisms to precision therapeutic breakthroughs.

Frontiers in immunology
2026

Risk score for early mortality to stratify for intensive SSc therapy in the EUSTAR network: the RESIST score.

Annals of the rheumatic diseases
2026

Performance of Circulating Inflammatory Biomarkers and Krebs von den Lungen 6 for Predicting Progressive Pulmonary Fibrosis in Patients With Systemic Sclerosis-Associated Interstitial Lung Disease.

ACR open rheumatology
2026

Nailfold capillaroscopy improves cardiovascular risk stratification in SSc: an adjustment of the SCORE2 algorithm.

Rheumatology (Oxford, England)
2026

Fibrosis-memory is mediated by IL-3-producing T cells and drives progression of fibrosis.

The Journal of clinical investigation
2026

Chronic graft versus host disease in upper limb: Calling upper limb rehabilitation specialists for improving outcomes in patients.

Clinical hematology international
2026

Optical coherence tomography angiography: a window on systemic sclerosis microangiopathy.

European journal of internal medicine
2026

Real-World Adherence to Systemic Sclerosis Quality Indicators: A Single-Center Quality of Care Study.

The Journal of rheumatology
2026

Scleroderma sine-Raynaud in children: the Fibrotic Subtype.

The Journal of rheumatology
2026

Increased incidence of sudden cardiac death in systemic sclerosis: data from a nationwide cohort study.

Seminars in arthritis and rheumatism
2026

Trends and outcomes of lung transplant listings for connective tissue disease-associated interstitial lung disease (CTD-ILD): A 20-Year analysis from the organ procurement and transplantation network database.

Seminars in arthritis and rheumatism
2026

Exploring Disease-Specific Risk Factors for Vertebral Fractures in Systemic Sclerosis: Insights from the ScleroRER Study Group.

Journal of clinical medicine
2026

Nailfold capillaroscopy and organ involvement in systemic sclerosis: a systematic review.

Best practice &amp; research. Clinical rheumatology
2026

Resting Oxygen Consumption Estimates in Scleroderma Can Lead to Underestimation of Cardiac Output.

Pulmonary circulation
2026

Analysis of fungal community structure and co-occurrence networks across vegetation types in volcanic lava habitats.

Frontiers in fungal biology
2026

Human MAGI1 expression in endothelial cells protects from the development of localized and systemic scleroderma in mice.

Arthritis research &amp; therapy
2026

Objective gastrointestinal involvement in patients with systemic sclerosis: Prevalence and clinico-immunological phenotypes in the REMSCLE registry.

Medicina clinica
2026

Dermatoscopy limitation and the critical role of capillaroscopy in the evaluation of systemic sclerosis and Raynaud's phenomenon among African American Veterans.

Seminars in arthritis and rheumatism
2026

Prevention and management of gastrointestinal side effects in patients with systemic sclerosis-interstitial lung disease receiving anti-fibrotic therapy: a modified Delphi consensus study.

Clinical and experimental rheumatology
2026

Intravenous immunoglobulin for the treatment of morphea in pediatric patients: A case series.

JAAD case reports
2026

Community-based management of gastrointestinal symptoms at end-of-life in scleroderma using subcutaneous medication: a case report.

Annals of palliative medicine
2026

The Th17/Treg axis: a key to understanding and treating autoimmune disorders.

Open life sciences
2025

A novel microneedle-based delivery of NRF2-overexpressing exosomes for scleroderma therapy.

International journal of biological macromolecules
2026

Nintedanib Attenuates Profibrotic Gene Expression in a 3D Organotypic Culture Model of Systemic Sclerosis Skin Fibrosis.

The Journal of investigative dermatology
2026

Longitudinal Assessment of the Juvenile Systemic Sclerosis Severity Score: Application in the National Registry for Childhood Onset Scleroderma.

ACR open rheumatology
2026

A retrospective analysis of clinical characteristics of systemic sclerosis-associated interstitial lung disease.

Medicine
2026

Case of generalized morphea complicated with systemic sclerosis.

Dermatology reports
2026

Exploring the anti-fibrotic effects of safflower in systemic sclerosis based on metabolomics and gut microbiota analyses.

Frontiers in pharmacology
2026

Identification of key macrophage-related genes in systemic sclerosis-associated interstitial lung disease based on single-cell and bulk transcriptomic data.

PloS one
2026

The clinical phenotype of anti-Th/To+ patients in systemic sclerosis: a case-control study within the European Scleroderma Trials and Research cohort.

Therapeutic advances in musculoskeletal disease
2026

Not all small bowel pneumatosis is ischaemia: a case-based systematic review of non-ischaemic causes.

Annals of the Royal College of Surgeons of England
2026

Recent advances in the heart and soul of primary cardiac involvement and cardiovascular disease in systemic sclerosis.

Best practice &amp; research. Clinical rheumatology
2026

Ill by mouth? Patients' experiences of the oral and dental manifestations of scleroderma.

Health (London, England : 1997)
2026

[Shulman syndrome: An atypical presentation of a rare disease].

Revista medica del Instituto Mexicano del Seguro Social
2026

Injectable platelet-rich fibrin as a valid therapeutic option for inactive linear morphea (en coup de saber): report of cases.

The Journal of dermatological treatment
2026

Generalized Morphea Successfully Treated With Tripterygium Glycosides and Hydroxychloroquine: A Case Report and a Systematic Review.

Cureus
2026

2025 expert consensus on the use of parenteral prostanoids in incident and prevalent PAH patients: The Italian perspective.

Vascular pharmacology
2026

Evaluation of non-invasive techniques for the diagnosis of pulmonary complications in systemic sclerosis and scleroderma-like overlap syndromes: role of lung ultrasound.

Journal of autoimmunity
2026

The Incidence of Painful Neuroma After Digital Amputation Due to Trauma Versus Chronic Ischemia.

Hand (New York, N.Y.)
2026

Outcomes Following Surgical Management of Advanced Oral Cavity Cancers in Patients with Scleroderma: A Case Series.

The Annals of otology, rhinology, and laryngology
2026

Reciprocal regulation of fibroblast-macrophage equilibrium governs skin integrity.

Nature immunology
2026

Scleroderma clinical trials consortium classification criteria for systemic sclerosis heart involvement.

Rheumatology (Oxford, England)
2026

Successful tocilizumab-based combination therapy for a case of rapidly progressive adult deep morphea with multiple antiphospholipid antibodies: a case report and literature review.

Frontiers in immunology
2026

A university career in basic and applied avian immunology: important contributions of chicken models for autoimmune diseases.

Frontiers in physiology
2026

Computed tomography of interstitial lung disease in systemic sclerosis: dataset and deep learning model for pulmonary lesion segmentation.

Reumatismo
2026

Temporomandibular joint disorders in patients with systemic sclerosis: a cross-sectional study.

BMC rheumatology
2026

Points to consider for reporting digital ulcers in systemic sclerosis interventional studies: An initiative from the world Scleroderma Foundation digital ulcer ad hoc committee.

Autoimmunity reviews
2026

Replay: Comparative Study of Adipose-Derived Stem Cells from Localized Scleroderma Patients and Healthy Donors in Treating Skin Fibrosis.

Plastic and reconstructive surgery
2026

Extended temporomandibular joint prosthetic reconstruction of total condylysis in the setting of severe scleroderma: a case report.

Oral and maxillofacial surgery
2026

Shared governance of international myositis networks.

Clinical and experimental rheumatology
2026

Long-term follow-up of linear scleroderma en coup de sabre in children with central nervous system involvement.

Frontiers in immunology
2026

A randomised open label pilot trial comparing mycophenolate mofetil with no immunosuppression in limited cutaneous systemic sclerosis (MINIMISE-Pilot).

Rheumatology (Oxford, England)
2026

Pericardial Decompression Syndrome After Large-Volume Pericardiocentesis in Systemic Sclerosis.

JACC. Case reports
2026

Integrating B Cell Differentiation Model With Real-World Data Informs Determinants for Antibody-Secreting Cell Depletions in Systemic Sclerosis.

CPT: pharmacometrics &amp; systems pharmacology
2026

Hyaluronic acid fillers in systemic sclerosis and localized scleroderma: A systematic review.

Autoimmunity reviews
2026

Evaluating context effects on PHQ-8 somatic item scores among people with a chronic medical condition: a scleroderma patient-centred intervention network randomised experiment.

Epidemiology and psychiatric sciences
2026

Reduced retinal microvascular density in patients with mixed connective tissue disease: an exploratory pilot study on the interplay between aging, renal function, and complement system.

Frontiers in immunology
2026

Case Report: Unusual persistent elevation of troponin I-systemic sclerosis masked by acute myocardial infarction.

Frontiers in immunology
2026

Carbon dioxide vs. warm-water hand baths in systemic sclerosis with secondary Raynaud's syndrome - A capillaroscopy centered randomized controlled trial.

Microvascular research
2026

Drug development in systemic sclerosis: novel therapeutics to watch.

Expert review of clinical immunology
2026

Prevalence and clinical relevance of systematically tested antimitochondrial antibodies in systemic sclerosis.

Arthritis research &amp; therapy
2026

Cytometry-based blood immune cell markers associated with clinical outcomes in systemic sclerosis: protocol for a systematic review.

BMJ open
2026

Mechanistic basis for the antifibrotic actions of cAMP-based therapies.

European respiratory review : an official journal of the European Respiratory Society
2026

Management of pulmonary arterial hypertension in systemic sclerosis: from classical treatments to new horizons.

European respiratory review : an official journal of the European Respiratory Society
2026

Assessing the structural validity of the SCL-Dep6 depression subscale using rasch analysis.

Journal of affective disorders
2026

Systemic sclerosis-associated pulmonary arterial hypertension and pulmonary fibrosis: exploring biomarker discriminators with advanced omics in a Caucasian cohort.

Frontiers in immunology
2026

An Under-Recognized Manifestation of Systemic Sclerosis: Macrovascular Peripheral Arterial Disease.

Cureus
2026

Prognostic biomarkers for idiopathic pulmonary fibrosis: findings from ISABELA clinical trials.

ERJ open research
2026

A potent inhibitor of PAI-1, MDI-2517, mitigates disease severity in a preclinical systemic sclerosis model.

JCI insight
2026

Ustekinumab-associated morphoea: systematic review of the literature and a real-world case.

Drugs in context
2026

Facial Swelling in a Young Adult With Type 1 Diabetes: Morbihan Disease as a Scleroderma Mimic.

Cureus
2026

An autopsy-proven case of normotensive scleroderma renal crisis with refractory pleuroperitoneal effusion.

CEN case reports
2026

Oral and maxillofacial manifestations of systemic sclerosis.

Best practice &amp; research. Clinical rheumatology
2026

Underrecognition of Fecal Incontinence in Systemic Sclerosis: Discrepancies Between the Rome IV Diagnostic Questionnaires and the UCLA Scleroderma Clinical Trials Consortium Gastrointestinal 2.0 Questionnaire.

The Journal of rheumatology
2026

Administration of Hormone Replacement Therapy Containing Estrogen and Development of Autoimmune Associated Vocal Fold Lesions in Women.

Journal of voice : official journal of the Voice Foundation
2026

Second to Fourth Digit Ratio (2D:4D) in Female Patients With Systemic Sclerosis: Evidence for Prenatal Androgen Exposure.

American journal of human biology : the official journal of the Human Biology Council
2026

Assessing digital vasculopathy in systemic sclerosis.

Rheumatology (Oxford, England)
2026

Advancing drug development for systemic sclerosis by prioritizing findings from human genetic association studies.

Rheumatology (Oxford, England)
2026

Exploring the optimal follow-up for systemic sclerosis patients: study protocol for a Dutch multicenter randomized controlled trial.

Trials
2026

Probabilistic Clustering Using Multivariate Growth Mixture Model in Clinical Settings-A Scleroderma Example.

Statistics in medicine
2026

Gastric disease in systemic sclerosis: Spectrum, challenges, and insights from a systematic literature review.

Seminars in arthritis and rheumatism
2026

Quantifying the Prevalence of Disorders of Gut Brain Interaction in Systemic Sclerosis.

Neurogastroenterology and motility
2026

Evaluation of serial cardiovascular magnetic resonance monitoring and immunosuppressive therapy in predicting outcomes in systemic sclerosis.

RMD open
2026

Development of enzyme-linked immunosorbent assays for the detection of myositis-specific autoantibodies against signal recognition particle, nuclear matrix protein 2, and small ubiquitin-like modifier activating enzyme.

Modern rheumatology
2026

Analysis of the Dynamics of Clinical Parameters and Serum Angiogenic Factors in Systemic Sclerosis Patients Undergoing Tocilizumab Treatment.

Experimental dermatology
2026

Age and onset timing of Raynaud's phenomenon and first non-Raynaud symptom as prognostic factors in systemic sclerosis: a retrospective analysis from the Italian national multicenter Systemic Sclerosis Progression INvestiGation registry of the Italian Society for Rheumatology (SPRING-SIR).

Therapeutic advances in musculoskeletal disease
2026

Reactive oxygen species driven immune inflammation in systemic sclerosis: mechanisms and emerging therapeutics.

Drug discovery today
2026

Delayed gastric emptying identifies a high-risk clinical subgroup in patients with systemic sclerosis.

Rheumatology (Oxford, England)
2026

Venous Abnormalities in Biopsy-confirmed Lipodermatosclerosis.

Advances in skin &amp; wound care
2026

Multi-omics profiling of chronic immune-mediated skin diseases: SKINERGY protocol and strategic evaluation.

Journal of the European Academy of Dermatology and Venereology : JEADV
2026

Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis.

Annals of the rheumatic diseases
2026

Research on the mechanism of Carthamus tinctorius L. against skin fibrosis in systemic sclerosis based on serum pharmacochemistry, network pharmacology, and experimental validation.

Journal of ethnopharmacology
2026

The Spectrum of Uveitis and Retinal Vasculitis in Systemic Sclerosis: A Case Series.

Ocular immunology and inflammation
2026

Impact of Hydroxychloroquine on Mortality and Cardiovascular Outcomes in Systemic Sclerosis: A Retrospective Cohort Study.

International journal of rheumatic diseases
2026

Atypical Presentation of Morphoea in an Elderly Male: Diagnostic Challenges in the Absence of Autoantibodies and Malignancy.

Cureus
2026

Juvenile systemic sclerosis.

Best practice &amp; research. Clinical rheumatology
2026

TPI1 and TPM4 are strong candidate RNA biomarkers for systemic sclerosis.

Arthritis research &amp; therapy
2026

Spectroscopic and machine learning approaches for clinical subtyping in systemic sclerosis.

Scientific reports
2026

Comparing Novel and Legacy Health Assessment Questionnaire Scoring Methods: A Scleroderma Patient-centered Intervention Network Cohort Study.

The Journal of rheumatology
2026

Factor Analysis to Determine Subgroups of Gastrointestinal Symptoms in Systemic Sclerosis.

The Journal of rheumatology
2026

Gastrointestinal involvement in systemic sclerosis: A spotlight on small bowel involvement, complications and management.

Best practice &amp; research. Clinical rheumatology
2026

Treatment of juvenile localized scleroderma with upadacitinib: A case series.

Journal of the European Academy of Dermatology and Venereology : JEADV
2026

Th17-related genes PGAP1 and TMBIM1 serve as potential diagnostic and predictive biomarkers in systemic sclerosis: bioinformatic identification and murine model validation.

Clinical rheumatology
2026

Risk stratifying systemic sclerosis-related pulmonary hypertension by left atrial strain.

Rheumatology (Oxford, England)
2025

Fc-enhanced anti-CCR6 antibody elicits robust therapeutic effects across multiple autoimmune diseases.

Frontiers in immunology
2025

Renal Vascular Affection in Systemic Sclerosis Patients and Possible Correlation with Peripheral Vascular Involvement Assessed by Nailfold Capillaroscopy.

Mediterranean journal of rheumatology
2026

Evaluation of a screening algorithm to detect systemic sclerosis-related myopathy.

Rheumatology (Oxford, England)
2026

Methotrexate and Mycophenolate Mofetil and Clinical Response in Juvenile Localized Scleroderma.

JAMA dermatology
2026

Association of MMP9 and NOS3 Polymorphisms with Distinct Clinical Forms of Juvenile Scleroderma and Characteristics of Humoral Immunity.

International journal of molecular sciences
2026

Connective Tissue Disease-Associated Pulmonary Arterial Hypertension: Current Therapeutic Strategies and Future Prospects.

Biomolecules
2026

Serum CCL18 May Reflect Multiorgan Involvement with Poor Outcome in Systemic Sclerosis.

Biomolecules
2026

JAK inhibitors for the treatment of juvenile localized scleroderma: a case report and literature review.

Pediatric rheumatology online journal
2026

Close association of kinesiophobia with physical performance in patients with systemic sclerosis.

Rheumatology international
2025

Prevalence and severity of complicated Raynaud's phenomenon in limited and diffuse systemic sclerosis: a multicenter study in Iraq.

Reumatologia
2026

Botulinum neurotoxin type A1 alleviates bleomycin-induced skin fibrosis by inhibiting phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) pathway and associated cell cycle and proliferation.

The Journal of investigative dermatology
2026

Gastrointestinal histology of systemic sclerosis: A systematic review.

Autoimmunity reviews
2026

Patient partnership model in rare and complex rheumatological conditions: research and beyond in European Reference Network ReCONNET.

The Lancet. Rheumatology
2026

Strengthening rheumatology research through meaningful engagement of people with lived experience.

The Lancet. Rheumatology
2026

Development of a tool to map SSc pain sources, characteristics and management experiences: the SPIN Pain Assessment Tool.

Rheumatology (Oxford, England)
2026

Linear scleroderma 'en coup de sabre'.

Practical neurology
2026

Like an Osteophyte. . . or Worse? A Curious Case of Dysphagia in a Patient With Scleroderma.

Ear, nose, &amp; throat journal
2026

Macrophages Are Critical Inducers of Bleomycin-Induced Fibrosis in a Systemic Scleroderma Model.

The American journal of pathology
2026

Surgical Management of Systemic Sclerosis: Review of Literature.

Current rheumatology reviews
2026

Forced vital capacity as a survival predictor in systemic sclerosis-associated pulmonary hypertension.

Therapeutic advances in musculoskeletal disease
2025

Esomeprazole inhibits proliferation of scleroderma fibroblasts via cell cycle regulation.

Frontiers in pharmacology
2026

Beyond the breast: Mammographic manifestations of systemic disease.

Current problems in diagnostic radiology
2026

Autoantibodies as Precision Tools in Connective Tissue Diseases: From Epiphenomenon to Endophenotype.

Antibodies (Basel, Switzerland)
2026

Differential Item Functioning on the Patient Health Questionnaire 8 by Disease Subtype, Language, Sex, and Age Among People With Systemic Sclerosis: A Scleroderma Patient-Centered Intervention Network Cohort Study.

Arthritis care &amp; research
2026

Systemic Sclerosis-Related Intestinal Pseudo-Obstruction Mimicking Mechanical Small Bowel Obstruction.

Cureus
2026

Contemporary 0.55 T MRI to visualize interstitial lung disease - An exploratory study.

European journal of radiology open
2026

The added value of cardiac MRI in paediatric rheumatologic disorders: a preliminary single-centre experience.

Cardiology in the young
2026

The incidence of interstitial lung disease in patients with systemic sclerosis: rate, risk factors and prognostic implications in a EUSTAR cohort analysis (CP 133).

Annals of the rheumatic diseases
2026

Deficiency of inducible nitric oxide synthase alleviates dermal fibrosis and inflammation in scleroderma.

International immunopharmacology
2026

Associations with, and predictors of, progression in systemic sclerosis-related interstitial lung disease: a scoping literature review.

European respiratory review : an official journal of the European Respiratory Society
2025

MASLD-Induced Hyperammonemia With Atypical, Restricted Diffusion Pattern Suggesting Mixed Metabolic and Hypoxic-Anoxic Injury.

HCA healthcare journal of medicine
2026

Tofacitinib treatment in a girl with localized scleroderma of the head and face: a case-based review.

Rheumatology international
2026

Skin Cancer Arising in Morphea: A Systematic Review.

Journal of cutaneous medicine and surgery
2025

A Case of Mandibular Osteomyelitis Occurring in a Patient With Parry-Romberg Syndrome.

Cureus
2026

Exploring the Association Between Autoimmune and Inflammatory Diseases and Uveitis.

American journal of ophthalmology
2026

Soluble CD13 in systemic sclerosis: clinical observations and transcriptomic insights from peripheral blood.

Arthritis research &amp; therapy
2025

Temporal Dynamics of Pulmonary Fibrosis and Immune Dysregulation in a Collagen V-Driven Systemic Sclerosis Model.

International journal of molecular sciences
2026

Systemic Sclerosis-Associated ILD: Insights and Limitations of ScleroID.

Diagnostics (Basel, Switzerland)
2025

A Case Report on a Challenge From Diagnosis to Treatment: Interstitial Lung Disease As the First Manifestation of Systemic Sclerosis Sine Scleroderma.

Cureus
2026

Heart Transplantation in Patients With Systemic Sclerosis.

Clinical transplantation
2026

Clinical Applications of Autologous Fat Grafting in Pathological Hand Conditions.

The journal of hand surgery Asian-Pacific volume
2026

Disease Course and Risk of Relapse in Juvenile Localized Scleroderma: A Single-Center Retrospective Study.

International journal of rheumatic diseases
2026

Clinical predictors of mortality in critically ill systemic sclerosis patients: a 6-year retrospective cohort study.

Rheumatology (Oxford, England)
2026

CD19 CAR-T cells for treatment-refractory autoimmune diseases: the phase 1/2 CASTLE basket trial.

Nature medicine
2026

Transcriptomic analysis under the stress of insecticides and the functional role of three genes related to host finding behavior of Scleroderma sichuanensis.

Comparative biochemistry and physiology. Part D, Genomics &amp; proteomics
2026

Interstitial lung disease in systemic sclerosis-a retrospective cross-sectional study in Taiwan.

Clinical rheumatology
2026

Mesenchymal stromal cells ameliorate systemic sclerosis-interstitial lung disease via PD-1/PD-L1 signalling axis.

RMD open
2025

Combination of Oral Hydroxychloroquine and Topical Pimecrolimus 1% for Linear Morphea in Breastfeeding: A Rare Case with Favorable Outcome.

International journal of women's health
2026

Nailfold videocapillaroscopy in the assessment of juvenile connective tissue diseases.

Clinical and experimental rheumatology
2026

Deficiency of NRF2 aggravates BLM-induced systemic sclerosis-associated fibrosis and inflammation in mice.

International immunopharmacology
2026

Expression and clinical significance of fatty acid metabolism-related genes in PBMCs of SSc patients.

Clinical rheumatology
2026

Skin-derived myeloid precursors and joint-resident fibroblasts spread psoriatic disease from skin to joints.

Nature immunology
2025

Subclinical right ventricular dysfunction in juvenile systemic sclerosis: a cross-sectional echocardiographic study.

ARP rheumatology
2025

Gangrenous Digital Ischemia Unmasking HIV Infection in Untreated Systemic Sclerosis.

Cureus
2026

The Evolution in the Cutaneous and Gastrointestinal Pathology of Pediatric Kohlmeier-Degos Disease Under Combined Modality Therapy.

The American Journal of dermatopathology
2025

Parry-Romberg Syndrome Associated With En Coup De Sabre: A Clinical Case Report.

Cureus
2025

MYCOPHENOLATE MOFETIL TREATMENT REDUCES THE RISK OF TREATMENT ESCALATION DUE TO VASCULAR COMPLICATIONS IN LIMITED CUTANEOUS SYSTEMIC SCLEROSIS: EMULATION OF A TARGET TRIAL FROM ITALIAN RHEUMATOLOGY SOCIETY SPRING REGISTRY.

Arthritis care &amp; research
2025

Chromosomal Instability and Telomere Attrition in Systemic Sclerosis: A Historical Perspective.

Genes
2025

Autoimmune disorders as predictive factors for oral lichen planus and malignancy risk: real-world data analysis.

Oral surgery, oral medicine, oral pathology and oral radiology
2026

Hand function impairment in Systemic Sclerosis: determinants through investigations of clinical, radiographic and ultrasonographic features.

Seminars in arthritis and rheumatism
2026

Pitfalls in the treatment of keloidal scleroderma.

Internal medicine journal
2025

Antineutrophil Cytoplasmic Antibody-Associated Vasculitides in Systemic Sclerosis: A Unique Clinical Overlap With Significant Implications for Treatment and Outcomes.

Arthritis &amp; rheumatology (Hoboken, N.J.)
2025

Single-Cell Profiling Reveals Divergent Mechanisms of Fibrosis in Localized Scleroderma and Systemic Sclerosis.

Arthritis &amp; rheumatology (Hoboken, N.J.)
2025

Effects of multimodal nutritional intervention on nutritional status and clinical outcomes in patients with systemic sclerosis: study protocol for a randomised controlled trial.

BMJ open
2025

From the grey area of pre-systemic sclerosis to very early disease and irreversible tissue damage: the challenge of defining at-risk patients for future preventive trials in systemic sclerosis.

Annals of the rheumatic diseases
2026

Atorvastatin alleviates the progression of fibrosis in experimental systemic sclerosis: Binding to macrophage CD14 to regulate TLR4/p65 or directly modulating fibroblast Smad3 signaling.

Free radical biology &amp; medicine
2025

Systemic Sclerosis-Recent Advances in Diagnosis and Management.

British journal of hospital medicine (London, England : 2005)
2025

Systemic Sclerosis-Associated Interstitial Lung Disease: Improved Understanding and Advances in Management.

British journal of hospital medicine (London, England : 2005)
2026

Work participation and work disability in Belgian patients with systemic sclerosis.

Rheumatology (Oxford, England)
2026

Integration of natural language models in the diagnosis of systemic autoimmune diseases: validation of GPT-4 in a tertiary care center.

Revista clinica espanola
2025

The altered T cell landscape in Systemic Sclerosis patients is characterized by dysfunctional type 1 immunity.

bioRxiv : the preprint server for biology
2026

Underrepresentation of Black participants in systemic sclerosis clinical trials: the U.S.A. and southeast region.

Clinical rheumatology
2025

The efficacy and safety of tocilizumab in juvenile localised scleroderma patients: a retrospective cohort study in Eastern China.

Advances in rheumatology (London, England)
2025

Radiographic Fibrosis Extent Identifies Immunomodulatory Treatment Response in Hypersensitivity Pneumonitis.

Chest
2026

[Eosinophilic fascitis: A case report and literature review].

Revista medica del Instituto Mexicano del Seguro Social
2025

Phosphodiesterase-4 inhibition in localized scleroderma: A case series of topical roflumilast.

SAGE open medical case reports
2026

SgA1d, an acid lipase from venom of the ectoparasitoid Scleroderma guani involved in the regulation of host lipid metabolism.

Pest management science
2026

Multimodal analyses of early, untreated systemic sclerosis skin identify a proinflammatory vascular niche of macrophage-fibroblast signaling.

JCI insight
2025

Trigeminal neuropathy as the first symptom of mixed connective tissue disease: case report and literature review.

Quintessence international (Berlin, Germany : 1985)
2025

Serum profiling of uPA, PAI-1, and suPAR in systemic sclerosis: a preliminary study on analytical aspects and associations with microvascular and fibrotic manifestations.

Frontiers in immunology
2026

Gut microbiome-metabolome dysregulation in systemic sclerosis: a multi-omics study.

Rheumatology (Oxford, England)
2026

Successful Treatment of Refractory Severe Localized Scleroderma With Anifrolumab.

JAMA dermatology
2026

Hidradenitis Suppurativa and Smoking, Obesity, Psoriasis, Inflammatory Bowel Disease, and Systemic Sclerosis: Results From A 2-Sample Mendelian Randomization Study.

JAMA dermatology
2026

Automated lung texture analysis for assessing interstitial lung disease in systemic sclerosis: Diagnostic accuracy in photon-counting-detector and conventional energy-integrating-detector CT.

European journal of radiology
2025

[POEMS syndrome misdiagnosed as systemic sclerosis: A case report].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
2025

[Rheumatic disease spectrum and immunological profile of anti-PM/Scl antibodies in idiopathic inflammatory myopathies].

Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Ver todos os 9.750 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Autologous stem cell transplant for severe, progressive juvenile systemic sclerosis.
    Stem cells translational medicine· 2026· PMID 41866801mais citado
  2. Automatic assessment of lung involvement in systemic sclerosis using deep learning.
    Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences· 2026· PMID 41858826mais citado
  3. Resting Oxygen Consumption Estimates in Scleroderma Can Lead to Underestimation of Cardiac Output.
    Pulmonary circulation· 2026· PMID 41815804mais citado
  4. The Th17/Treg axis: a key to understanding and treating autoimmune disorders.
    Open life sciences· 2026· PMID 41799642mais citado
  5. Identification of key macrophage-related genes in systemic sclerosis-associated interstitial lung disease based on single-cell and bulk transcriptomic data.
    PloS one· 2026· PMID 41785251mais citado
  6. Tocilizumab as a Potential Alternative Therapy for Acute Exacerbation of Systemic Sclerosis-Associated Interstitial Lung Disease in a Dialysis Patient Following Immunodeficiency-Associated Lymphoproliferative Disorders.
    Cureus· 2026· PMID 41994749recente
  7. Physical rehabilitation interventions for hand function in people with systemic sclerosis.
    Best Pract Res Clin Rheumatol· 2026· PMID 41991397recente
  8. Clinical relevance of specific and non-specific autoantibodies in systemic sclerosis without overlap features.
    Semin Arthritis Rheum· 2026· PMID 41990462recente
  9. The Effect of Adding Paraffin Bath to the Therapeutic Hand Exercise Programme on Hand Functions in Patients with Systemic Sclerosis: A Randomized, Controlled, Single-Blind Study.
    Arch Rheumatol· 2026· PMID 41989449recente
  10. Systemic sclerosis-related digital ulcers: Current understanding and updated management approaches- a primer for clinicians.
    Semin Arthritis Rheum· 2026· PMID 41985412recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:801(Orphanet)
  2. MONDO:0019340(MONDO)
  3. Esclerose Sistemica(PCDT · Ministério da Saúde)
  4. GARD:18705(GARD (NIH))
  5. Variantes catalogadas(ClinVar)
  6. Busca completa no PubMed(PubMed)
  7. Artigo Wikipedia(Wikipedia)
  8. Q958797(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Esclerodermia
Compêndio · Raras BR

Esclerodermia

ORPHA:801 · MONDO:0019340
🇧🇷 Brasil SUS
Geral
Prevalência
1-5 / 10 000
Herança
Not applicable
CID-10
M34 · Esclerose sistêmica
Ensaios
9 ativos
Início
All ages
Prevalência
42.0 (Worldwide)
MedGen
UMLS
C0011644
Repurposing
2 candidatos
halofuginonecollagenase inhibitor
potassium-p-aminobenzoate
EuropePMC
Wikidata
Wikipedia
Papers 10a
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