A esclerodermia localizada é a forma localizada de esclerodermia caracterizada por fibrose da pele causando placas ou faixas cutâneas.
Introdução
O que você precisa saber de cara
A esclerodermia localizada é a forma localizada de esclerodermia caracterizada por fibrose da pele causando placas ou faixas cutâneas.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 17 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 55 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Esclerodermia localizada
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Outros ensaios clínicos
33 ensaios clínicos encontrados, 6 ativos.
Publicações mais relevantes
Methotrexate and Mycophenolate Mofetil and Clinical Response in Juvenile Localized Scleroderma.
Currently, there are no treatments approved by the US Food and Drug Administration for juvenile localized scleroderma (JLS), a rare disease. While methotrexate (MTX) is regularly used as a first-line therapy, emerging data from case series and applications in systemic sclerosis suggest that mycophenolate mofetil (MMF) may be clinically comparable, with potential benefits in tolerability and adherence. To compare clinical outcomes of patients with JLS treated with MTX and MMF using standardized clinical outcome measures. This retrospective cohort study of patients with clinician-diagnosed JLS who were enrolled in the National Registry of Childhood Onset Scleroderma was conducted at UPMC Children's Hospital of Pittsburgh. Data were from January 2010 to January 2023 and first analyzed in April 2023. All patients were evaluated and followed up by the same physician. Patients were included if they had disease onset before age 18 years and a localized scleroderma diagnosis and enrollment in the National Registry of Childhood Onset Scleroderma before age 21 years. Patients were required to be receiving MTX monotherapy, MMF monotherapy, or combination therapy (CT) of the 2 for their localized scleroderma. Patients were treated with MTX, MMF, or CT as prescribed by the examining physician. This study measured comparative medication treatment response through associations with disease activity, as measured using the Localized Scleroderma Cutaneous Assessment Tool. Of 114 patients, 77 (67.5%) were female, and the median (IQR) age at onset was 8.3 (5.4-11.2) years. The MTX, MMF, and CT groups included 68 (59.6%), 28 (24.6%), and 18 patients (15.8%), respectively. There were no significant differences in baseline demographic characteristics, disease subtype, or disease severity between groups, but patients in the MMF group had longer disease duration. Mixed-effects modeling showed statistically significant decreases in activity across all groups (β = -0.14; 95% CI, -0.62 to 0.33). A Kaplan-Meier analysis showed no significant difference in disease flare rate over the follow-up interval (hazard ratio, 0.85; 95% CI, 0.51-1.33). However, patients treated with MTX compared with those treated with MMF had significantly higher rates of fatigue (47% vs. 11%, P = .001) and nausea (60% vs. 7%; P = .001). The study results suggest that MMF demonstrated a similar response to treatment as MTX in reducing disease activity in JLS, with comparable flare rates and improved tolerability. These initial findings support MMF as a potential candidate for first-line treatment of JLS. Prospective, randomized, noninferiority trials are warranted to confirm these results and guide future treatment recommendations.
Association of MMP9 and NOS3 Polymorphisms with Distinct Clinical Forms of Juvenile Scleroderma and Characteristics of Humoral Immunity.
Juvenile scleroderma (JS), comprising localized (JLSd) and systemic (JSSc) forms, is a rare autoimmune disorder. This study investigated associations of polymorphisms in extracellular matrix (MMP1, MMP9) and vascular homeostasis (NOS3) genes with JS risk and immunological phenotypes. A case-control study involved 215JS patients (194 JLSd, 21 JSSc) and 72 controls. SNPs (MMP1 rs1799750, MMP9 rs3918242, NOS3 rs1799983) were genotyped using real-time PCR followed by minisequencing and mass spectrometric analysis of reaction products. Associations with disease risk, subtypes, and immunological markers were analyzed statistically. The MMP9 (rs3918242) CT genotype was significantly associated with JLSd (OR = 2.23, 95% CI: 1.14-4.37, p = 0.022), showing a trend in linear facial forms. The NOS3 (rs1799983) GG genotype demonstrated a trend toward association with JSSc (OR = 2.61, 95% CI: 0.92-7.37, p = 0.065). No significant associations were found for rs1799750 MMP1 and risk of disease development. The MMP9 risk genotype did not correlate with scleroderma-specific autoantibodies, while the NOS3 GG genotype was associated with lower serum levels of anti-collagen IV antibodies (p = 0.039). Genetic associations differ for JS subtypes: MMP9 with JLSd and NOS3 with JSSc. Children with CT polymorphism MMP9 (rs3918242) and with NOS3 (rs1799983) GG genotype were found to be genetically predisposed for the development of JS.
Successful Treatment of Refractory Severe Localized Scleroderma With Anifrolumab.
This case report describes a woman in her 20s with a history of linear morphea diagnosed in childhood who presented with disease progression despite long-term treatment.
Remote Skin and Blood Sampling for Translational Connective Tissue Disorder Research: A Proof-of-Concept Pilot Study.
Remote, noninvasive biospecimen collection methods can address geographic and mobility-related barriers to participation in translational research for connective tissue disorders. We evaluated the feasibility of combining noninvasive skin tape stripping and Tasso capillary blood collection to molecularly profile lupus and morphea in remote settings using mailed kits. RNA extraction was optimized from 20 serial tape strips per site, with overnight shipping and scraping samples in buffer without sonication, yielding the highest concentration and quality. We enrolled 8 patients with lupus, 3 patients with morphea, and 8 healthy controls. Microarray analysis identified upregulation of CXCL9, CCR6, and PDGFRA in lupus and morphea skin. Proteomic analysis revealed elevated IFN-γ, TNFRSF4, and ANGPT2 in lupus serum, with lower IL-13 than in controls. Morphea samples showed increased expression of markers, including PDGFRA, P2RX1, and KALRN. Distinct gene expression signatures of CTGF, TNFRSF4, and MAFB in lupus skin and ALOX15, KALRN, and P2RX1 in morphea skin enabled differentiation between morphea and lupus. CXCL9 and IFN-γ biomarkers were confirmed in other publicly available datasets at both the protein and RNA levels. These findings provide proof of concept that remote RNA and protein profiling is feasible and reproducibly identifies canonical and, to our knowledge, previously unreported disease markers; however, the small number of patients and the lack of more complete characterization of the participants studied require that further studies are needed to establish the role of these findings in the pathogenesis of lupus and morphea. This approach enables broader inclusion of underserved patients and offers a scalable model for remote biomarker studies in dermatologic and autoimmune research.
A practical clinical approach to the diagnosis and management of morphea (localized scleroderma).
Morphea, also referred to as localized cutaneous scleroderma, encompasses a heterogeneous group of inflammatory and fibrosing skin disorders characterized by variable depth of tissue involvement and different clinical course. The diagnostic delay remains common due to insidious onset, broad differential diagnosis, and lack of validated biomarkers of disease activity. Clinical assessment relies therefore on expert evaluation, supported by clinical scoring systems and selected imaging techniques. Therapeutic strategies depend on disease subtype, activity, depth, and risk of irreversible damage, ranging from topical agents for limited superficial forms to systemic immunosuppression for deep, linear, generalized, and pansclerotic variants. Methotrexate combined with systemic corticosteroids represents the current first-line systemic therapy, while mycophenolate mofetil and biologics or targeted synthetic agents are increasingly used in refractory disease. This review provides a comprehensive and updated overview of the epidemiology, clinical spectrum, diagnostic approach, and management of morphea across age groups, highlighting recent therapeutic advances, and unmet clinical needs.
Publicações recentes
Conventional ultrasound combined with shear wave elastography for assessing disease activity in pediatric localized scleroderma: a prospective pilot study.
A practical clinical approach to the diagnosis and management of morphea (localized scleroderma).
Circumscribed Morphea Successfully Treated With Excimer Laser: Analysis of Histopathological Changes.
Human MAGI1 expression in endothelial cells protects from the development of localized and systemic scleroderma in mice.
Case of generalized morphea complicated with systemic sclerosis.
📚 EuropePMC637 artigos no totalmostrando 199
A practical clinical approach to the diagnosis and management of morphea (localized scleroderma).
Best practice & research. Clinical rheumatologyCircumscribed Morphea Successfully Treated With Excimer Laser: Analysis of Histopathological Changes.
The Journal of dermatologyHuman MAGI1 expression in endothelial cells protects from the development of localized and systemic scleroderma in mice.
Arthritis research & therapyCase of generalized morphea complicated with systemic sclerosis.
Dermatology reportsInjectable platelet-rich fibrin as a valid therapeutic option for inactive linear morphea (en coup de saber): report of cases.
The Journal of dermatological treatmentGeneralized Morphea Successfully Treated With Tripterygium Glycosides and Hydroxychloroquine: A Case Report and a Systematic Review.
CureusSuccessful tocilizumab-based combination therapy for a case of rapidly progressive adult deep morphea with multiple antiphospholipid antibodies: a case report and literature review.
Frontiers in immunologyReplay: Comparative Study of Adipose-Derived Stem Cells from Localized Scleroderma Patients and Healthy Donors in Treating Skin Fibrosis.
Plastic and reconstructive surgeryHyaluronic acid fillers in systemic sclerosis and localized scleroderma: A systematic review.
Autoimmunity reviewsUstekinumab-associated morphoea: systematic review of the literature and a real-world case.
Drugs in contextAtypical Presentation of Morphoea in an Elderly Male: Diagnostic Challenges in the Absence of Autoantibodies and Malignancy.
CureusTreatment of juvenile localized scleroderma with upadacitinib: A case series.
Journal of the European Academy of Dermatology and Venereology : JEADVMethotrexate and Mycophenolate Mofetil and Clinical Response in Juvenile Localized Scleroderma.
JAMA dermatologyAssociation of MMP9 and NOS3 Polymorphisms with Distinct Clinical Forms of Juvenile Scleroderma and Characteristics of Humoral Immunity.
International journal of molecular sciencesJAK inhibitors for the treatment of juvenile localized scleroderma: a case report and literature review.
Pediatric rheumatology online journalBotulinum neurotoxin type A1 alleviates bleomycin-induced skin fibrosis by inhibiting phosphatidylinositol 3-kinase-protein kinase B (PI3K-Akt) pathway and associated cell cycle and proliferation.
The Journal of investigative dermatologyTofacitinib treatment in a girl with localized scleroderma of the head and face: a case-based review.
Rheumatology internationalSkin Cancer Arising in Morphea: A Systematic Review.
Journal of cutaneous medicine and surgeryDisease Course and Risk of Relapse in Juvenile Localized Scleroderma: A Single-Center Retrospective Study.
International journal of rheumatic diseasesCombination of Oral Hydroxychloroquine and Topical Pimecrolimus 1% for Linear Morphea in Breastfeeding: A Rare Case with Favorable Outcome.
International journal of women's healthParry-Romberg Syndrome Associated With En Coup De Sabre: A Clinical Case Report.
CureusSingle-Cell Profiling Reveals Divergent Mechanisms of Fibrosis in Localized Scleroderma and Systemic Sclerosis.
Arthritis & rheumatology (Hoboken, N.J.)Phosphodiesterase-4 inhibition in localized scleroderma: A case series of topical roflumilast.
SAGE open medical case reportsSuccessful Treatment of Refractory Severe Localized Scleroderma With Anifrolumab.
JAMA dermatologyEvaluation of localized scleroderma by line-field confocal optical coherence tomography.
Italian journal of dermatology and venereologyParry-Romberg Syndrome With Localized Scleroderma: A Report of Two Pediatric Cases From Oman.
Cureus[En coup de sabre linear scleroderma with central nervous system involvement in a pediatric patient].
Zhurnal nevrologii i psikhiatrii imeni S.S. KorsakovaJanus Kinase Inhibitors for the Treatment of Pediatric Morphea: A Systematic Review.
Pediatric dermatologyTemporal dynamics of ADSC therapy in skin fibrosis: unraveling the roles of ROS/NF-κB/TSG-6 signaling axis.
Stem cell research & therapyRemote Skin and Blood Sampling for Translational Connective Tissue Disorder Research: A Proof-of-Concept Pilot Study.
JID innovations : skin science from molecules to population healthBarriers to Surgical Care in Craniofacial Scleroderma (Parry-Romberg Syndrome).
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationLocalized scleroderma and related comorbidities: a single-centre cohort study.
The British journal of dermatologyPansclerotic Morphea, Refractory to Multiple Systemic Therapies, Successfully Treated with UVA-1 Phototherapy.
Case reports in dermatologyAre systemic sclerosis and localized scleroderma (morphea) part of a common disease spectrum? A systematic review on their coexistence.
Clinics in dermatologyPediatric Localized Scleroderma With Favorable Response to 308-nm Excimer Light Therapy.
Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.]Sclerosing diseases of the skin.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGRevealing Microvascular Involvement in Pediatric Localized Scleroderma Through Nailfold Capillaroscopy.
Children (Basel, Switzerland)Injectable Immune-Regulating Mesenchymal Stem Cells Hydrogel for Localized Scleroderma Treatment.
ACS nanoSclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody.
BloodAdipose-derived mesenchymal stem cells and their derivatives in inflammatory skin diseases: a systematic review.
Frontiers in immunologyReviewing the Developing Significance of the Serine Protease PRSS23.
Frontiers in bioscience (Landmark edition)Recombinant Human Annexin A5 Ameliorates Localized Scleroderma by Inhibiting the Activation of Fibroblasts and Macrophages.
PharmaceuticsThe Therapeutic Effects of Semaglutide in Congenital Linear Scleroderma.
CureusPirfenidone in Skin Fibrosis and Scarring: From Bench Insights to Clinical Data.
Medical sciences (Basel, Switzerland)Plastic Surgery Interventions for Localized Scleroderma Deformities: an Evidence Synthesis.
Aesthetic plastic surgeryComparative Efficacy and Safety of Treatments for Morphea: A Systematic Review.
Journal of cutaneous medicine and surgeryAutoimmune inner ear disease and localized scleroderma in childhood: A case report.
Reumatologia clinicaHigh-content Image-based Drug Testing of Patients' Primary Fibroblasts Reveals Potential New Treatment Options for Localized Scleroderma.
Acta dermato-venereologicaNodular morphea on the breast of a pregnant woman-case report and literature review.
Wiener medizinische Wochenschrift (1946)Asymptomatic Anterior Uveitis without Systemic Activity in en Coup de Sabre Scleroderma: A Case Report.
Ocular immunology and inflammationJanus kinase inhibitors in localized scleroderma: a systematic literature review.
Turkish journal of medical sciencesSingle-cell sequencing combined with spatial transcriptomics reveals the characteristics of follicle-targeted inflammation patterns in primary cicatricial alopecia.
Cell & bioscienceValidation of CXCL9 as a biomarker of morphoea disease state and severity through longitudinal analysis.
The British journal of dermatologyScleroderma Overlapping With Sjögren's Syndrome: A Case Report of a Renal Emergency.
CureusLocalized Morphea in a Pediatric Patient Successfully Treated With Topical Ruxolitinib.
Pediatric dermatologyThe role of selected cytokines from the interleukin 1 family in the pathophysiology of morphea.
Archives of dermatological researchPseudo oculomotor palsy associated with Parry-Romberg syndrome.
Archivos argentinos de pediatriaIs adiponectin involved in morphea pathogenesis? - first observational study.
Frontiers in immunology[A case of autoinflammatory disease with STAT4 variant and localized scleroderma].
Zhonghua er ke za zhi = Chinese journal of pediatricsJuvenile localized scleroderma: a large retrospective cohort study from a tertiary care center.
Pediatric rheumatology online journalLocalized scleroderma: multiparametric MRI with diffusion-weighted imaging and gadolinium-based perfusion imaging for assessing disease activity.
Skeletal radiologyDevastating neurologic consequences of localized scleroderma en coup de sabre of the scalp-2 case studies.
Journal of scleroderma and related disordersNew Challenging Systemic Therapies for Juvenile Scleroderma: A Comprehensive Review.
Pharmaceuticals (Basel, Switzerland)Effect of UV-A1 Phototherapy Treatment on Scleroderma: A Systematic Review.
Cureus[Disseminated atrophoderma of Pasini and Pierini with blaschkoid appearance].
Dermatologie (Heidelberg, Germany)Successful treatment of localized scleroderma using brodalumab: A case report.
SAGE open medical case reportsUse of the oral Janus kinase inhibitor tofacitinib in the treatment of morphea: A retrospective study.
Journal of the American Academy of DermatologyHistopathological and molecular analysis in dermis and epidermis of patients with systemic and localized scleroderma.
Northern clinics of IstanbulmiR-143-3p boosts extracellular vesicles to improve the dermal fibrosis of localized scleroderma.
Journal of autoimmunityA clinical guide to oral manifestations and diagnosis of limited systemic sclerosis: a case report.
General dentistryRasmussen encephalitis and localized scleroderma of the lower limb: Another piece of the puzzle. A case-report and literature review with individual participant data.
Journal of neuroimmunologyIncidence, prevalence, and mortality of localized scleroderma in Quebec, Canada: a population-based study.
Lancet regional health. AmericasUnique and shared transcriptomic signatures underlying localized scleroderma pathogenesis identified using interpretable machine learning.
JCI insightThe burden of extracutaneous manifestations in juvenile localized scleroderma: A literature review.
Autoimmunity reviewsSolitary Morphea Profunda: A Case Report.
Mymensingh medical journal : MMJEFFICACY AND TOLERABILITY OF JANUS KINASE INHIBITOR TOFACITINIB IN JUVENILE LINEAR SCLERODERMA. CASE SERIES OF 5 PATIENTS.
Georgian medical newsLocalized scleroderma: anatomic MRI findings of morphea with inter-reader analysis.
Skeletal radiologySocioeconomic factors associated with the development of localized scleroderma: a cross-sectional study.
Archives of dermatological researchDevelopment of Coup de Sabre in an HIV-Positive Patient: A Case Study from Lilongwe, Malawi.
The American journal of tropical medicine and hygieneNationwide epidemiological and clinical survey of juvenile-onset morphea in Japan.
The Journal of dermatology[Oral localized scleroderma: case study].
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatologyEfficacy and safety of platelet-rich plasma therapy in systemic sclerosis and localized scleroderma; a systematic review.
Archives of dermatological researchCoexistence of Lichen Sclerosus and Morphea in a Single Vulvar Lesion.
CureusMarkers of Type 2 Inflammation and Immunosenescence Are Upregulated in Localized Scleroderma.
International journal of molecular sciencesUse of biologic drug in the treatment of localized scleroderma and systemic sclerosis in children: A scoping review.
Seminars in arthritis and rheumatismA Challenging Case of Eosinophilic Fasciitis Without Classic Histopathological Findings.
The Permanente journalA case of localized scleroderma with variable response to excimer light therapy.
The Journal of dermatologyComparative study between fractional CO2 laser (10,600 nm) and microneedling in treatment of morphea: dermoscopic and histopathological evaluation.
Archives of dermatological researchA case series of dermatopathological features in different types of morphea and their clinical correlates.
Indian journal of pathology & microbiologyHigh-Density Fat Combined With Stromal Vascular Fraction Gel for the Treatment of Facial Localized Scleroderma.
The Journal of craniofacial surgeryAdvanced Neuroimaging and Clinical Findings in a Case of Linear Scleroderma En Coup De Sabre Presenting With Seizures.
CureusImiquimod for the treatment of morphea: a systematic review.
Archives of dermatological researchWhat Is New in Morphea-Narrative Review on Molecular Aspects and New Targeted Therapies.
Journal of clinical medicineBenefits of the Topical JAK Inhibitor Delgocitinib in a Patient With Pediatric Localized Scleroderma.
Pediatric dermatologyLinear Scleroderma En Coup de Sabre: A Case Series With Eyelid Involvement and Management.
Ophthalmic plastic and reconstructive surgeryProfiling of Toll-like Receptors and Related Signaling Mediators in the Pathogenesis of Morphea.
Dermatology practical & conceptualEvaluation of Thiol Disulfide, Ischemia Modified Albumin, and Prolidase Parameters in Patients with Localized Scleroderma.
Dermatology practical & conceptualAssociation of Black Race with Demographic, Comorbidities, and Outcome Variables in Localized Scleroderma Patients: A Retrospective Analysis of the 2017 US National Inpatient Sample.
Dermatology practical & conceptualJOINT LESIONS - COMMON EXTRACUTANEOUS MANIFESTATION IN JUVENILE LOCALIZED SCLERODERMA.
Georgian medical newsSTROKE AS A LIFE-THREATENING COMPLICATION IN CHILDREN WITH LINEAR SCLERODERMA OF FACE.
Georgian medical newsEvaluation of autologous fat grafting in the treatment of juvenile localized scleroderma with facial involvement.
Journal of scleroderma and related disordersNational Registry for Childhood Onset Scleroderma I: Insights from the first 341 juvenile localized scleroderma patients.
Journal of scleroderma and related disordersDisabling pansclerotic morphoea: a century of discovery.
The British journal of dermatologyHeart transplantation in juvenile-onset systemic sclerosis with primary cardiac involvement: report of two cases and comprehensive literature review.
Current problems in cardiologyRetrospective Review of Morphea in Paediatric Patients with Skin of Colour.
Journal of cutaneous medicine and surgeryOutcomes of Fat Grafting in the Active Versus Quiescent Phase of Localized Scleroderma.
Plastic surgery (Oakville, Ont.)Calcium Hydroxyapatite as a Co-adjuvant Treatment Option in a Patient With Morphea: A Report of a Case With a One-Year Follow-Up.
CureusCharacterization of Endothelial Cell Subclusters in Localized Scleroderma Skin with Single-Cell RNA Sequencing Identifies NOTCH Signaling Pathway.
International journal of molecular sciencesRare Case of Limited Systemic Sclerosis with Left Ventricle Aneurysm.
The Journal of the Association of Physicians of IndiaComparative Study of Adipose-Derived Stem Cells from Localized Scleroderma Patients and Healthy Donors in Treating Skin Fibrosis.
Plastic and reconstructive surgeryInterferon-Gamma-Inducible Protein-10 (IP-10) and Tumor Necrosis Factor-α (TNF-α) as Serological Predictors of Active Disease Status in Localized Scleroderma.
International journal of molecular sciencesChallenges and complications in juvenile localized scleroderma: A practical approach.
Best practice & research. Clinical rheumatologyHistopathologic spectrum of morphea: a single-center retrospective study.
Dermatology reportsThe causal effects of inflammatory and autoimmune skin diseases on thyroid diseases: evidence from Mendelian randomization study.
Frontiers in endocrinologySpatial Transcriptomics Identifies Cellular and Molecular Characteristics of Scleroderma Skin Lesions: Pilot Study in Juvenile Scleroderma.
International journal of molecular sciencesExploring the relationship between morphea and malignancy: a decade-long single-center study of 204 patients.
Archives of dermatological researchCase Report: Exacerbation after fat grafting in patients with active localized scleroderma.
Frontiers in surgerySingle-cell RNA sequencing identifies inherent abnormalities of adipose-derived stem cells from nonlesional sites of patients with localized scleroderma.
Cellular & molecular biology lettersAdvances in the Management of Localized Scleroderma: A Systematic Review of Laser Therapy and Injectable Filler Approaches.
Journal of personalized medicineMagnetic Resonance Imaging in the Assessment and Management of Post-injection-Site Morphea.
Cureus[Bullous morphea: A rare form of localized scleroderma].
Annales de pathologieEndpoints and outcomes for localized scleroderma/morphea: a scoping literature review.
Pediatric rheumatology online journalA Rare Case of Bullous Morphea Associated with Autoimmune Hepatitis.
Journal of clinical medicineThe role of excimer light in dermatology: a review.
Anais brasileiros de dermatologiaScleroderma-like Lesions in a Patient Undergoing Combined Pembrolizumab and Routine Chemotherapy: A Case Report and Literature Review.
Medicina (Kaunas, Lithuania)Capillaroscopy in the daily clinic of the pediatric rheumatologist.
Best practice & research. Clinical rheumatologyAtypical chemokine receptor 1-positive endothelial cells mediate leucocyte infiltration and synergize with secreted frizzled-related protein 2/asporin-positive fibroblasts to promote skin fibrosis in systemic sclerosis.
The British journal of dermatologyA consensus-based electronic medical record template for pediatric morphea patient visits.
Pediatric dermatologyExtragenital lichen sclerosus et atrophicus-morphea overlap as an initial presentation of genital lichen sclerosus.
Dermatology online journalHigh-frequency ultrasound evaluation of morphea: Retrospective analytical study.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)The Serological Evidence of Positive Rheumatoid Factor in Morphea Patients and Its Relation to Disease Severity.
CureusClinical and ultrasonographic evaluation of efficacy and safety of intralesional injection of autologous platelet-rich plasma in morphea: A comparative case series.
Journal of scleroderma and related disordersType-2 immunity associated with type-1 related skin inflammatory diseases: friend or foe?
Frontiers in immunologyLocalized Scleroderma Burden: A Scoping Review Focusing on the Health-Related Quality of Life, Mental Health, and Productivity.
Journal of cutaneous medicine and surgeryResponsiveness to Change of the Morphea Activity Measure in Pediatric Patients.
JAMA dermatologyUltrasonographic Evaluation of Juvenile Localized Scleroderma: Enhancing Objectivity in Diagnosis and Management.
Current medical imagingEvidence for the causal relationship between rheumatoid arthritis and localized scleroderma: a two-sample mendelian randomization study.
Archives of dermatological researchOverlap of Scleroderma and Class V Lupus Nephritis: A Rare Autoimmune Confluence.
CureusTracking Fat Grafts by Magnetic Resonance Imaging: A Comparative Study of Adolescent and Adult Patients with Stable Localized Scleroderma.
Plastic and reconstructive surgeryIntraoral Involvement in Linear Scleroderma En Coup De Sabre: A Case Report.
CureusInterferons dominate damage and activity in juvenile scleroderma.
Modern rheumatologyAutomated anatomical landmark detection on 3D facial images using U-NET-based deep learning algorithm.
Quantitative imaging in medicine and surgeryTransition to Adult Rheumatology Care: A Disease-Specific Guide.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseasesPre-scleroderma and new opportunities for preventive medicine.
The Lancet. RheumatologyAntibody status against measles and rubella in juvenile localized scleroderma patients on synthetic DMARDs: a prospective case-control study.
Rheumatology (Oxford, England)Consensus statement on the diagnosis and treatment of sclerosing diseases of the skin, Part 1: Localized scleroderma, systemic sclerosis and overlap syndromes.
Journal of the European Academy of Dermatology and Venereology : JEADVRaynaud's phenomenon associated with psoriatic arthritis.
BMJ case reportsS2k guideline: Diagnosis and therapy of localized scleroderma.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGDamage evaluation of craniofacial localized scleroderma using magnetic resonance imaging.
Quantitative imaging in medicine and surgeryJuvenile eosinophilic fasciitis: a single center case series.
Pediatric rheumatology online journalNintedanib in systemic sclerosis treatment: a case report.
Journal of medical case reportsA Comparison of Clinical, Demographic and Treatment Characteristics of Pediatric-Onset and Adult-Onset Patients Diagnosed With Localized Scleroderma.
Dermatology practical & conceptualMass spectrometry -based proteomic analysis of the skin of patients with localized scleroderma.
Journal of dermatological scienceClinical, Histologic, and Transcriptomic Evaluation of Sequential Fat Grafting for Morphea: A Nonrandomized Controlled Trial.
JAMA dermatologyNovel multispectral imaging to predict disease progression in pediatric morphea.
Pediatric dermatologyPerspective to precision medicine in scleroderma.
Frontiers in immunologyThe role of skin ultrasound in systemic sclerosis: looking below the surface to understand disease evolution.
The Lancet. RheumatologyMRI Digital Artery Volume Index (DAVIX) as a surrogate outcome measure of digital ulcer disease in patients with systemic sclerosis: a prospective cohort study.
The Lancet. RheumatologyDevelopment of Morphea Following Treatment with an ADA Biosimilar: A Case Report.
Current rheumatology reviews[Juvenile localized scleroderma].
Dermatologie (Heidelberg, Germany)Measurement equivalence of the English and French versions of the self-efficacy to manage chronic disease scale: a Scleroderma Patient-Centered Intervention Network (SPIN) study.
Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitationInvited Response on: "Fat Grafting Reduces Skin Hyperpigmentation of Localized Scleroderma Patients: A Prospective Self-controlled Study".
Aesthetic plastic surgeryMorphea Involving the Lips and Gingiva: A Rare Case Report.
CureusBest clinical practice in the treatment of juvenile systemic sclerosis: expert panel guidance - the result of the International Hamburg Consensus Meeting December 2022.
Expert review of clinical immunologyCapturing the Range of Disease Involvement in Localized Scleroderma: The Localized Scleroderma Total Severity Scale.
Arthritis care & researchSynthetic Nucleic Acid Antigens in Localized Scleroderma.
International journal of molecular sciencesClinical characteristics of juvenile systemic sclerosis in Korea: 31-year single-center study.
Journal of rheumatic diseasesLetter on Fat Grafting Reduces Skin Hyperpigmentation of Localized Scleroderma Patients: A Prospective Self-controlled Study.
Aesthetic plastic surgeryBrown adipose tissue transplantation improves skin fibrosis in localized scleroderma.
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyPatients with autoimmune skin diseases are at increased risk of adverse pregnancy outcomes.
American journal of obstetrics & gynecology MFMConnective tissue nevus misdiagnosed as juvenile localized scleroderma.
Pediatric rheumatology online journalBULGARIAN PATIENT WITH ATROPHODERMA OF PASINI AND PIERINI- DESCRIPTION OF A CASE AND SHORT UPDATE.
Georgian medical newsNodular (keloidal) scleroderma.
Reumatologia clinicaOrthodontic management of a patient with linear morphea.
Journal of clinical orthodontics : JCOMorphea, Eosinophilic Fasciitis and Cancer: A Scoping Review.
CancersSystematic Review of Health-Related Quality of Life Impact in Juvenile Localized Scleroderma.
Arthritis care & researchExosomes from human adipose-derived mesenchymal stem cells attenuate localized scleroderma fibrosis by the let-7a-5p/TGF-βR1/Smad axis.
Journal of dermatological scienceClinical and Histological Characteristics of Localized Morphea, Generalized Morphea and Systemic Sclerosis: A Comparative Study Aided by Machine Learning.
Acta dermato-venereologicaA case of transient paradoxical early morphea-like eruption after the first injection of dupilumab in a patient with chronic rhinosinusitis with nasal polyps.
Italian journal of dermatology and venereologyArsenic trioxide demonstrates efficacy in a mouse model of preclinical systemic sclerosis.
Arthritis research & therapyBony Hyperplasia Beneath Atrophic Soft Tissue: A Rare Case of En Coup de Sabre and Literature Review.
Clinical, cosmetic and investigational dermatologyIL-6 trans-signaling in a humanized mouse model of scleroderma.
Proceedings of the National Academy of Sciences of the United States of AmericaDoes the Impact of COVID-19 on Patients With Systemic Sclerosis Change Over Time?
Arthritis care & researchDiagnosing and Managing Linear Scleroderma in a Low-Resource Setting.
Case reports in pediatricsImages in Vascular Medicine: Subcutaneous panniculitis-like T-cell lymphoma mimicking lipodermatosclerosis.
Vascular medicine (London, England)Fat Grafting Reduces Skin Hyperpigmentation of Localized Scleroderma Patients: A Prospective Self-controlled Study.
Aesthetic plastic surgeryThe Reactivation of Scleroderma After Autologous Fat Grafting.
The Journal of craniofacial surgeryFree Superficial Circumflex Iliac Artery/Superficial Inferior Epigastric Artery Adipofascial Flaps for Facial Reconstruction of Linear Scleroderma.
Annals of plastic surgeryEn Coup de Sabre in a Pediatric Patient Treated With Calcipotriene.
CureusColor Doppler Ultrasound Assessment of Subclinical Activity With Scoring of Morphea.
Journal of cutaneous medicine and surgeryNon-invasive imaging and clinical skin scores in juvenile localized scleroderma.
Rheumatology (Oxford, England)Role of imaging in morphea assessment: A review of the literature.
Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)The Collaborative National Quality and Efficacy Registry for Scleroderma: association of medication use on gastrointestinal tract symptoms in early disease and the importance of tobacco cessation.
Clinical and experimental rheumatologyPansclerotic morphea is characterized by IFN-γ responses priming dendritic cell fibroblast crosstalk to promote fibrosis.
JCI insightSystemic therapy in juvenile localized scleroderma.
Expert review of clinical immunologyCase Report: Real NPSLE? A patient with systemic sclerosis overlapping systemic lupus erythematosus presenting as epilepsy.
Frontiers in immunologySpontaneous crateriform indentation in a child.
Pediatric dermatologyTransplantation of in vitro prefabricated adipose organoids attenuates skin fibrosis by restoring subcutaneous fat and inducing dermal adipogenesis.
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyLearnings from clinical trials in patients with connective tissue disease-associated interstitial lung disease.
Arthritis research & therapyAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Esclerodermia localizada.
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Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Esclerodermia localizada
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Methotrexate and Mycophenolate Mofetil and Clinical Response in Juvenile Localized Scleroderma.
- Association of MMP9 and NOS3 Polymorphisms with Distinct Clinical Forms of Juvenile Scleroderma and Characteristics of Humoral Immunity.
- Successful Treatment of Refractory Severe Localized Scleroderma With Anifrolumab.
- Remote Skin and Blood Sampling for Translational Connective Tissue Disorder Research: A Proof-of-Concept Pilot Study.
- A practical clinical approach to the diagnosis and management of morphea (localized scleroderma).
- Conventional ultrasound combined with shear wave elastography for assessing disease activity in pediatric localized scleroderma: a prospective pilot study.
- Circumscribed Morphea Successfully Treated With Excimer Laser: Analysis of Histopathological Changes.
- Human MAGI1 expression in endothelial cells protects from the development of localized and systemic scleroderma in mice.
- Case of generalized morphea complicated with systemic sclerosis.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:90289(Orphanet)
- MONDO:0019562(MONDO)
- Esclerose Sistemica(PCDT · Ministério da Saúde)
- GARD:7058(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q3324389(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
