Linfoma cutâneo é um grupo de doenças muito diverso, que se manifesta de várias formas. Ele varia bastante em suas características clínicas (o que o médico observa no paciente) e patológicas (o que se vê nos exames de laboratório), na forma como a doença evolui, no prognóstico (a previsão de como a doença vai se comportar), em sua causa molecular (ligada aos genes) e na resposta aos tratamentos. Todas essas particularidades foram consideradas nas classificações mais recentes. Nessas classificações, foi dada uma importância especial ao que cada um desses diferentes tipos significa para o prognóstico (o futuro da doença).
Introdução
O que você precisa saber de cara
Linfoma cutâneo é um grupo de doenças muito diverso, que se manifesta de várias formas. Ele varia bastante em suas características clínicas (o que o médico observa no paciente) e patológicas (o que se vê nos exames de laboratório), na forma como a doença evolui, no prognóstico (a previsão de como a doença vai se comportar), em sua causa molecular (ligada aos genes) e na resposta aos tratamentos. Todas essas particularidades foram consideradas nas classificações mais recentes. Nessas classificações, foi dada uma importância especial ao que cada um desses diferentes tipos significa para o prognóstico (o futuro da doença).
Tem tratamento?
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Entender a doença
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Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 28 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 69 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
6 genes identificados com associação a esta condição.
Cell surface receptor implicated in modulating innate and adaptive immune responses. Generally accepted to have an inhibiting function. Reports on stimulating functions suggest that the activity may be influenced by the cellular context and/or the respective ligand (PubMed:24825777). Regulates macrophage activation (PubMed:11823861). Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance (PubMed:14556005). In CD8+ cells attenuates T
Cell membraneCell junction
Receptor with high affinity for TNFSF2/TNF and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF. Isoform 2 blocks TNF-induced apoptosis, which suggests that it regulates TNF function by antagonizing its biological activity
Cell membraneSecreted
Receptor that plays a role in T-cell activation, proliferation, survival and the maintenance of immune homeostasis (PubMed:1650475, PubMed:7568038). Functions not only as an amplifier of TCR signals but delivers unique signals that control intracellular biochemical events that alter the gene expression program of T-cells (PubMed:24665965). Stimulation upon engagement of its cognate ligands CD80 or CD86 increases proliferation and expression of various cytokines in particular IL2 production in bo
Cell membraneCell surface
Immunodeficiency 123 with HPV-related verrucosis
An autosomal recessive immunologic disorder characterized by susceptibility to human papilloma virus (HPV) infections and the development of HPV-related common verrucosis in the first decade of life. In some patients with HPV2 infection, warts may progress to severe generalized hyperkeratotic cutaneous papillomatosis with cutaneous horns ('tree-man' phenotype). In patients with HPV4 infection, warts remains stable and may even regress with age.
Inhibitory receptor acting as a major negative regulator of T-cell responses (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:18641304, PubMed:28484017). Acts as a decoy receptor: the affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (PubMed:11279501, PubMed:11279502, PubMed:16551244, PubMed:1714933, PubMed:28484017)
Cell membrane
Systemic lupus erythematosus
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stran
Nucleus, nucleolusNucleus, nucleoplasmCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Tyrosine kinase of the non-receptor type involved in numerous cytokines and interferons signaling, which regulates cell growth, development, cell migration, innate and adaptive immunity (PubMed:10542297, PubMed:10995743, PubMed:7657660, PubMed:7813427, PubMed:8232552). Plays both structural and catalytic roles in numerous interleukins and interferons (IFN-alpha/beta) signaling (PubMed:10542297). Associates with heterodimeric cytokine receptor complexes and activates STAT family members including
Immunodeficiency 35
A primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and highly elevated serum IgE.
Medicamentos e terapias
Mecanismo: Retinoid X receptor agonist
Mecanismo: Interleukin-2 receptor binding agent
Mecanismo: Histone deacetylase inhibitor
Mecanismo: Histone deacetylase 6 inhibitor
Mecanismo: C-C chemokine receptor type 4 cross-linking agent
Variantes genéticas (ClinVar)
88 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
31 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Linfoma cutâneo primário
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
4 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
32 ensaios clínicos encontrados, 8 ativos.
Publicações mais relevantes
Primary Cutaneous Follicle Center Lymphoma of the Nasal Dorsum and Tip Treated by Surgical Excision and Full-Thickness Skin Graft Reconstruction: A Case Report.
Primary cutaneous follicle center lymphoma (PCFCL) is an indolent subtype of primary cutaneous B-cell lymphoma that may present diagnostic challenges due to its variable clinical appearance and frequent overlap with benign inflammatory or neoplastic skin conditions. We report the case of a 79-year-old male patient who presented with a persistent pruritic and erythematous lesion involving the nasal dorsum and tip. Initial dermatologic evaluation and limited skin biopsy failed to establish a definitive diagnosis, and the lesion was managed conservatively without improvement. Given persistent symptoms and anatomical involvement, wide surgical excision with oncologic intent was performed after systemic staging excluded extracutaneous disease. Immediate reconstruction was achieved using a full-thickness skin graft harvested from an upper blepharoplasty performed in the same operative session. Histopathological examination of the excised specimen confirmed the diagnosis of PCFCL with tumor-free margins. Postoperative recovery was uneventful, and at 12-month follow-up, the patient demonstrated satisfactory functional and aesthetic outcomes with no evidence of local recurrence. This case highlights the potential for PCFCL to masquerade as a benign inflammatory condition, the limitations of small diagnostic biopsies, and the importance of adequate tissue sampling. It also underscores the role of surgical excision with tailored reconstruction as an effective diagnostic and therapeutic strategy in selected cases of localized PCFCL involving the nasal region.
Primary Cutaneous Lymphomas in Children: A Case Series Review with Emphasis on Diagnostic Imaging and Multidisciplinary Management.
Primary Cutaneous Lymphomas (PCLs) are rare extranodal non-Hodgkin lymphomas that present in the skin without extracutaneous disease at diagnosis; they are exceptionally uncommon in children and frequently mimic benign dermatoses, delaying recognition. We report a case series of three pediatric patients managed at a national referral center. Case 1: A 16-year-old with erythrodermic mycosis fungoides (stage IIIA) refractory to multiple systemic and skin-directed therapies who achieved remission after haploidentical allogeneic hematopoietic stem-cell transplantation. Case 2: A 3-year-old with aggressive cytotoxic CD8-positive Tcell lymphoma with EBV-associated disease and severe infectious complications during CHOP-based therapy, culminating in death despite salvage treatments and EBRT. Case 3: A 10-year-old with CD30-positive primary cutaneous anaplastic large cell lymphoma with a relapsing course, treated with BFM-90 chemotherapy, gemcitabine, pegylated doxorubicin plus total skin electron beam therapy, and ongoing PUVA with good dermatologic control. Across cases, diagnosis relied on clinicopathologic correlation with immunohistochemistry and staging CT; serum IgE was elevated in all three children. Pediatric PCLs show heterogeneous behavior and therapeutic responses. Early biopsy of atypical or treatment-refractory eruptions, comprehensive histopathology and immunophenotyping, targeted EBV testing when suggested, and appropriate use of skin-directed radiotherapy (EBRT/TSEBT) and transplantation in selected refractory disease are essential. Multidisciplinary management and equitable access to specialized therapies are critical to optimize outcomes.
Haematopoietic stem cell transplant in cutaneous T-cell lymphomas: A multicentre propensity-score matched study.
Advanced cutaneous T-cell lymphomas (CTCL) are rare, generally refractory to therapeutic options, and have a poor prognosis. Haematopoietic stem cell transplantation (HSCT), mainly allogeneic HSCT (allo-HSCT), is considered a potentially curative option in CTCL refractory to other therapies. However, around half of patients relapse, and allo-HSCT is associated with significant adverse events. The available evidence on the usefulness of HSCT in CTCL generally comes from isolated cases and case series with a limited number of patients. Our aim was to evaluate the outcome of patients undergoing HSCT for advanced primary CTCL in Spain in a real-world environment and to compare their survival with that of similar patients who did not receive HSCT. We performed a retrospective observational study nested within the Primary Cutaneous Lymphoma Registry (RELCP) of the Spanish Academy of Dermatology and Venereology, collecting data on all patients receiving HSCT. Then, we performed propensity score matching (PSM) to pair HSCT patients with non-HSCT patients, adjusting for diagnosis, highest disease stage and age at diagnosis. We then performed survival analysis by means of Cox regression. Of 2848 patients included in the RELCP, 51 patients underwent HSCT. Thirty-six patients (70.6%) achieved a complete response and seven patients (13.7%) partial response. Relapse was developed by 56.9% of patients, and 39.2% died (19.6% due to disease progression and 15.7% due to HSCT complications, mainly graft-versus-host disease (GVHD) and sepsis). Overall survival (OS) after HSCT at 5 years was 58.9%. No differences in OS were found between HSCT and non-HSCT groups. We did not observe a survival benefit among HSCT patients compared to non-HSCT patients within the RELCP cohort. This could be due to patients having received a mean of 6.3 lines of treatment before HSCT. Larger studies might help identify subgroups of patients who might benefit from HSCT.
Clinical Warburg Effect in a primary cutaneous lymphoma.
[Recent Research Advances in Classification and Treatment of Primary Cutaneous Lymphoma--Review].
Primary cutaneous lymphoma (PCL) is a group of heterogeneous diseases. Traditional chemotherapy methods often result in substantial toxic side effects due to their low tumor selectivity. Currently, individualized therapy based on the genetic characteristics and target molecules of tumors constitutes the main treatment strategy for managing PCL. In recent years, research on novel treatment options has developed rapidly. These innovative therapies, which primarily include monoclonal antibodies, immune checkpoint inhibitors, small-molecule inhibitors, and chimeric antigen receptor T-cell (CAR-T) therapies, not only expand the treatment options for patients but also significantly improve their survival outcomes. The objective of this article is to provide a comprehensive review of the latest classification system for PCL and the most recent research advancements in cutting-edge treatment strategies. 原发性皮肤淋巴瘤的分类及治疗最新研究进展. 原发性皮肤淋巴瘤(PCL)是一组异质性疾病。传统的化疗方法因其较低的肿瘤选择性常常伴随着显著的毒副作用。目前，基于肿瘤的遗传学特征和靶分子的个体化治疗构成了PCL的主要治疗策略，关于新型治疗方案的研究在近年来发展迅速。这些新颖疗法主要包括单克隆抗体、免疫检查点抑制剂、小分子抑制剂和嵌合抗原受体T细胞疗法等，不仅为患者提供了更多的治疗选择，而且显著延长了患者的生存期。本文旨在对PCL的最新分类以及当前最新治疗方案的研究进展作一综述。 .
Publicações recentes
Moderate-Dose Local Radiotherapy in Symptomatic CD30-Positive, Anaplastic Lymphoma Kinase (ALK)-Negative Primary Cutaneous T-cell Lymphoma.
Acalabrutinib treatment in relapsed/refractory primary cutaneous diffuse large B cell lymphoma, leg type. Case report.
Primary Cutaneous Follicle Center Lymphoma of the Nasal Dorsum and Tip Treated by Surgical Excision and Full-Thickness Skin Graft Reconstruction: A Case Report.
Primary Cutaneous Lymphomas in Children: A Case Series Review with Emphasis on Diagnostic Imaging and Multidisciplinary Management.
[Recent Research Advances in Classification and Treatment of Primary Cutaneous Lymphoma--Review].
📚 EuropePMC85 artigos no totalmostrando 152
Primary Cutaneous Follicle Center Lymphoma of the Nasal Dorsum and Tip Treated by Surgical Excision and Full-Thickness Skin Graft Reconstruction: A Case Report.
CureusPrimary Cutaneous Lymphomas in Children: A Case Series Review with Emphasis on Diagnostic Imaging and Multidisciplinary Management.
Current medical imaging[Recent Research Advances in Classification and Treatment of Primary Cutaneous Lymphoma--Review].
Zhongguo shi yan xue ye xue za zhiClinical Warburg Effect in a primary cutaneous lymphoma.
Clinical hematology internationalAngiogenesis and lymphangiogenesis in primary cutaneous lymphomas: a narrative review.
Clinical and experimental medicineFacial Presentation of Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type: A Rare Case.
CureusModern approaches to radiotherapy in primary cutaneous lymphomas: insights and recommendations from the DEGRO dermato-oncology working group.
Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]Subcutaneous Panniculitis-Like T-Cell Lymphoma in Children: Two Case Reports.
Clinical, cosmetic and investigational dermatologyT- and NK-cell lymphomas and leukemias: Insights from the 2023 Society for Hematopathology/European Association for Haematopathology Workshop.
American journal of clinical pathologyCare and treatment for primary cutaneous lymphoma-associated ulcers: Two case reports.
SAGE open medical case reportsPrimary cutaneous lymphoma is a microsatellite stable tumor: An analysis of microsatellite instability.
Drug discoveries & therapeuticsTiger-man Appearance in a Case of DLBCL.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaHow to treat primary cutaneous B cell lymphoma - Results from a monocentric cohort study on 98 patients.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGA current view of the pathogenesis and treatment of primary cutaneous diffuse large B cell lymphoma - leg type.
Leukemia & lymphomaA Rare Case of Primary Cutaneous CD4+ Small/Medium Size T-Cell Lymphoproliferative Disorder Responding to Rituximab.
Case reports in dermatologyAdvances in classification and treatment of primary cutaneous lymphomas.
Annals of hematologyUpdated Classification of Cutaneous Lymphoma.
Advances in anatomic pathologyHaematopoietic stem cell transplant in cutaneous T-cell lymphomas: A multicentre propensity-score matched study.
Journal of the European Academy of Dermatology and Venereology : JEADVA Gastrointestinal Manifestation of Primary Cutaneous Aggressive Epidermotropic Cytotoxic T-Cell Lymphoma: A Case Report.
CureusNon-Invasive Imaging Including Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Diagnosis of Cutaneous Lymphomas.
CancersRadiotherapy in cutaneous lymphomas: Recommendations from the EORTC cutaneous lymphoma tumour group.
European journal of cancer (Oxford, England : 1990)Secondary lymphomas of the skin.
Dermatology reportsEnigmatic Presentation of Primary Cutaneous Lymphoma in a Boy.
Plastic and reconstructive surgery. Global openPrevalence, clinical features, and survival outcome trends of 627 patients with primary cutaneous lymphoma over 29 years: a retrospective review from single tertiary center in Korea.
Scientific reportsNavigating Diagnostic and Therapeutic Challenges in Primary Cutaneous Gamma/Delta T-Cell Lymphoma: A Case Study of Fatal Outcomes Within Two Months.
The American Journal of dermatopathologyPreliminary Experience in Ultra-High Frequency Ultrasound Assessment of Cutaneous Primary Lymphomas: An Innovative Classification.
CancersPrimary cutaneous lymphoma in children and adolescents: An epidemiological descriptive study in a Greek population.
Journal of the European Academy of Dermatology and Venereology : JEADVSézary Syndrome in West Sweden: Exploring Epidemiology, Clinical Features, and Treatment Patterns in a Registry-Based Retrospective Analysis.
CancersPrimary cutaneous, epidermotropic mycosis fungoides-like presentation: critical appraisal and description of two novel cases, broadening the spectrum of ALK+ T-cell lymphoma.
Virchows Archiv : an international journal of pathologyPaediatric cutaneous lymphomas including rare subtypes: A 40-year experience at a tertiary referral centre.
Journal of the European Academy of Dermatology and Venereology : JEADVVaried presentations of primary cutaneous lymphoma: A case series from a tertiary care center in South India.
Indian journal of cancerAn unusual presentation of subcutaneous panniculitis-like T-cell lymphoma: Extensive necrosis and hemophagocytic lymphohistiocytosis: A case report.
Clinical case reportsExtensive Cutaneous-Mucosal and Muscular Involvement of Gamma/Delta Cutaneous T-Cell Lymphoma on 18 F-FDG PET/CT.
Clinical nuclear medicineBridging the specialty gap: Update on primary cutaneous lymphomas.
Journal of the American Academy of DermatologyCharacteristics of Primary Cutaneous Lymphoma in Italy: A Tertiary Care, Single-Center Study.
Current oncology (Toronto, Ont.)Subcutaneous panniculitis-like T-cell lymphoma: Morphological, immunophenotypical and clonality assessment in six cats.
Veterinary dermatology[Clinical Features and Prognostic Factors of Patients with Primary Cutaneous Lymphoma].
Zhongguo shi yan xue ye xue za zhiEpidemiology of cutaneous T-cell lymphomas: state of the art and a focus on the Italian Marche region.
European journal of dermatology : EJDCase report: Successful treatment of Chidamide in a refractory/recurrent SPTCL with ARID1A mutation on the basis of CHOP plus auto-HSCT.
MedicineCD5+ Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type, Presenting as an Asymptomatic Nodule.
Hematology reportsImmediate Response to Brentuximab Vedotin in a Patient with Localized MF-LCT.
Case reports in dermatologyPrimary cutaneous lymphoma in a patient with mastocytosis: Is there an association?
JAAD case reportsAn Update on Recent Advances of Photodynamic Therapy for Primary Cutaneous Lymphomas.
PharmaceuticsPediatric Primary Cutaneous Lymphoma in China: A Retrospective Study.
Dermatology (Basel, Switzerland)18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Scan Findings in a Rare Case of Subcutaneous Panniculitis-Like T-Cell Lymphoma.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaThe role of 18F-FDG PET/CT in primary cutaneous lymphoma: an educational review.
Annals of nuclear medicinePrimary Cutaneous B-Cell Lymphomas with Large Cell Morphology: A Practical Review.
International journal of molecular sciences[Translated article] Primary Cutaneous Lymphoma Registry of the Spanish Academy of Dermatology and Venereology (AEDV): Data for the First 5 Years.
Actas dermo-sifiliograficasMycosis Fungoides and Sézary Syndrome: Microenvironment and Cancer Progression.
CancersSynchronous occurrence of primary cutaneous B-cell lymphoma and cutaneous Rosai-Dorfman disease in distinct lesions: A unique association.
Journal of cutaneous pathologyRapidly progressive tumor stage mycosis fungoides: A case report from Syria.
Annals of medicine and surgery (2012)Primary Cutaneous B-Cell Lymphoma Co-Existing with Mycosis Fungoides-A Case Report and Overview of the Literature.
Life (Basel, Switzerland)Subcutaneous Panniculitis-like T-Cell Lymphoma with a Transformation to Lupus Erythematosus Panniculitis: A Case Report.
Case reports in dermatologySurgical, Dermatological and Morphopathological Considerations in the Diagnosis and Treatment of Cutaneous Lymphoproliferative Tumors, Primary CD4.
Medicina (Kaunas, Lithuania)Recent advances in cutaneous lymphoma-implications for current and future classifications.
Virchows Archiv : an international journal of pathologyDiagnostic Outcomes and Treatment Modalities in Patients with Mycosis Fungoides in West Sweden-A Retrospective Register-Based Study.
CancersBrentuximab vedotin in the treatment of cutaneous T-cell lymphomas: Data from the Spanish Primary Cutaneous Lymphoma Registry.
Journal of the European Academy of Dermatology and Venereology : JEADVPrimary cutaneous lymphoma patients seen at a referral dermatological centre in 1 year: A single-centre observational retrospective cohort study of the diagnoses and staging, comorbidities and associated symptoms, treatment performed and clinical course.
Journal of the European Academy of Dermatology and Venereology : JEADVRole of PET imaging in peritoneal involvement of subcutaneous panniculitis-like T-cell lymphoma.
Journal of radiology case reportsPrimary cutaneous lymphoma: the 2018 update of the WHO-EORTC classification.
Presse medicale (Paris, France : 1983)Primary cutaneous lymphoma and risk for severe COVID-19: a prospective study of 48 cases in Morocco.
Journal of the European Academy of Dermatology and Venereology : JEADVA Case of CD5-Positive Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type Secondary to Chronic Lymphedema.
The American Journal of dermatopathologyPediatric Cutaneous Hematologic Disorders: Cutaneous Lymphoma and Leukemia Cutis-Experience of a Tertiary-Care Pediatric Institution and Review of the Literature.
Journal of cutaneous medicine and surgerySafety and danger of biologic treatments in psoriasis in context of cutaneous T-cell lymphoma (CTCL).
Postepy dermatologii i alergologiiPrimary cutaneous gamma/delta T-cell lymphoma in Taiwan: A series of six cases with frequent solitary presentation and relatively indolent behavior.
Journal of cutaneous pathologyPrimary cutaneous lymphoma: recommendations for clinical trial design and staging update from the ISCL, USCLC, and EORTC.
BloodPrimary cutaneous lymphomas in children: A prospective study from the Spanish Academy of Dermatology and Venereology (AEDV) Primary Cutaneous Lymphoma Registry.
Pediatric dermatology[New national treatment guidelines for primary cutaneous lymphoma].
LakartidningenPrimary cutaneous indolent B-cell lymphomas - a retrospective multicenter analysis and a review of literature.
Acta oncologica (Stockholm, Sweden)Report of Eleven Patients of Subcutaneous Panniculitis-Like T-Cell Lymphoma: Clinicopathologic Features, 18F-FDG PET/CT Findings and Outcome.
Frontiers in oncologyPatients with primary cutaneous lymphoma are at risk for severe COVID-19. Data from the Spanish Primary Cutaneous Lymphoma Registry.
Journal of the European Academy of Dermatology and Venereology : JEADVSingle-cell RNA sequencing profiling in a patient with discordant primary cutaneous B-cell and T-cell lymphoma reveals micromilieu-driven immune skewing.
The British journal of dermatologyA Case of Cutaneous Blastic Plasmacytoid Dendritic Cell Neoplasm Treated With a Bcl-2 Inhibitor.
Journal of drugs in dermatology : JDDChidamide induces long-term remission in rare subcutaneous panniculitis-like T-cell lymphoma: An unusual case report and literature review.
International journal of immunopathology and pharmacologyPrimary cutaneous lymphoma: a population-based cancer registry descriptive study of 155 consecutive cases diagnosed between 1979 and 2016.
Leukemia & lymphomaPrimary Cutaneous Acral CD8+ T-cell Lymphoma Induced by Persistent Delayed Hypersensitivity to Gold Earrings.
Actas dermo-sifiliograficasMycosis Fungoides with Dermal Mucin Deposition: An Unusual Variant of the Most Challenging Primary Cutaneous Lymphoma.
Case reports in dermatologyHelical Skin Radiation Therapy Including Total Skin Radiation Therapy Using Tomotherapy for Primary Cutaneous Lymphoma With Bone Marrow Suppression as a Related Adverse Event.
Practical radiation oncologyCorrigendum: Management of primary cutaneous lymphoma patients during COVID-19 pandemic: EORTC CLTF guidelines.
Journal of the European Academy of Dermatology and Venereology : JEADVThe Clinical Spectrum of Primary Cutaneous CD4+ Small/Medium-Sized Pleomorphic T-Cell Lymphoproliferative Disorder: An Updated Systematic Literature Review and Case Series.
Dermatology (Basel, Switzerland)Primary cutaneous peripheral T-cell lymphoma, not otherwise specified with mammalian target of rapamycin mutation: A novel finding for targeted treatment.
JAAD case reportsAcral lymphomatoid papulosis: Report of five cases, differential diagnosis, and review.
Journal of cutaneous pathologyInfliximab-related atypical lymphoid hyperplasia mimicking primary cutaneous lymphoma of the ear.
Dermatologic therapyDermoscopy of Syringotropic and Folliculotropic Mycosis Fungoides.
Dermatology practical & conceptualCutaneous Lymphomas -Part II: Other Cutaneous Lymphomas.
Actas dermo-sifiliograficasBorrelia burgdorferi in primary cutaneous lymphomas: a systematic review and meta-analysis.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDGCutaneous Lymphomas - Part I: Mycosis Fungoides, Sézary Syndrome, and CD30+ Cutaneous Lymphoproliferative Disorders.
Actas dermo-sifiliograficasClinical Remission in a 72-Year-Old Patient with a Massive Primary Cutaneous Peripheral T-Cell Lymphoma-NOS of the Eyelid, Following Combination Chemotherapy with Etoposide Plus COP.
Diagnostics (Basel, Switzerland)Time to Next Treatment as a Meaningful Endpoint for Trials of Primary Cutaneous Lymphoma.
CancersSystemic rituximab for the treatment of the indolent forms of primary cutaneous B-cell lymphomas: Data from the Spanish Primary Cutaneous Lymphoma Registry.
Journal of the American Academy of DermatologyA case of primary cutaneous B-cell lymphoma with immature features in an old man. Diffuse large B-cell lymphoma with immature features or B-cell lymphoblastic lymphoma?
Journal of cutaneous pathologyPrimary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type: A Case Report.
CureusTotal skin electron beam therapy for primary cutaneous T-cell lymphomas: clinical characteristics and outcomes in a Mexican reference center.
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyA Case Report of Pityriasis Lichenoides-Like Mycosis Fungoides in Children: A Challenging Diagnosis.
Korean journal of family medicineManagement of primary cutaneous lymphoma patients during COVID-19 pandemic: EORTC CLTF guidelines.
Journal of the European Academy of Dermatology and Venereology : JEADVThe prognostic role of age in primary cutaneous B-cell lymphoma: a proposal derived from a population-based registry.
Aging clinical and experimental researchDiffuse large B cell lymphoma progression with skin involvement: A case report.
Journal of tissue viabilityOsteoma cutis in the setting of primary cutaneous lymphoma.
Journal of cutaneous pathology18FDG PET/CT in Primary Cutaneous Diffuse Large B-Cell Lymphoma Leg Type.
Clinical nuclear medicineMycosis Fungoides: A Clinicopathological Study of 60 Cases from a Tertiary Care Center.
Indian journal of dermatologyPrimary Cutaneous Gamma-Delta T-Cell Lymphoma With Long-Term Indolent Clinical Course Initially Mimicking Lupus Erythematosus Profundus.
Frontiers in oncologyPrimary cutaneous γδ T-cell lymphoma with unusual immunophenotype: A case report and review of published work.
The Journal of dermatologyThe clinico-pathological spectrum of primary cutaneous lymphoma other than mycosis fungoides/Sezary syndrome.
Virchows Archiv : an international journal of pathologyMolecular profiling of TOX-deficient neoplastic cells in cutaneous T cell lymphoma.
Archives of dermatological researchA retrospective review of cutaneous lymphoma in Botswana.
International journal of dermatologyMycosis fungoides in pediatric patients: Clinical features, diagnostic challenges, and advances in therapeutic management.
Pediatric dermatologyAssociated primary tumours in patients with primary cutaneous lymphoma: a single-centre retrospective cohort study.
Journal of the European Academy of Dermatology and Venereology : JEADVRecent Advances in Cutaneous T-cell Lymphoma: Diagnostic and Prognostic Considerations.
Surgical pathology clinicsClinical characteristics of primary cutaneous lymphoma: analysis from two centres in China.
The British journal of dermatologyTreatment of primary cutaneous anaplastic large cell lymphoma.
Archives of craniofacial surgeryRF - Brentuximab as Treatment for CD30+ Primary Cutaneous Lymphoma.
Actas dermo-sifiliograficasLinfoma anaplásico de células T grandes primario cutáneo CD30+. Serie de nueve casos.
Gaceta medica de MexicoSubcutaneous Panniculitis-Like T-Cell Lymphoma With Granulomas as the Predominant Feature.
The American Journal of dermatopathologyRecent advances in localized immunotherapy of skin cancers.
ImmunotherapyPrimary cutaneous Epstein-Barr virus-positive diffuse large B-cell lymphoma: a rare and aggressive cutaneous lymphoma.
CutisThe clinical value of imaging in primary cutaneous lymphomas: Role of high resolution ultrasound and PET-CT.
The British journal of radiologyEarly dermoscopic sign of folliculotropism in patients with mycosis fungoides.
Dermatology practical & conceptualPrimary cutaneous lymphoma in Argentina: a report of a nationwide study of 416 patients.
International journal of dermatologyLocal radiation for cutaneous T-cell lymphoma other than mycosis fungoides and Sézary syndrome.
Chinese clinical oncologyLight and shadows of a new technique: is photon total-skin irradiation using helical IMRT feasible, less complex and as toxic as the electrons one?
Radiation oncology (London, England)Subcutaneous panniculitis-like T-cell lymphoma: Clinical features, therapeutic approach, and outcome in a case series of 16 patients.
Journal of the American Academy of DermatologyClinical and epidemiological profile of patients with early stage mycosis fungoides.
Anais brasileiros de dermatologiaHydromorphone-induced chorea as an atypical presentation of opioid neurotoxicity: A case report and review of the literature.
Palliative medicine[Primary cutaneous lymphoma-a case series of 163 patients].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte GebieteThe First Year of the AEVD Primary Cutaneous Lymphoma Registry.
Actas dermo-sifiliograficasPrimary cutaneous lymphoma in children: A report of four cases.
The Turkish journal of pediatricsMycosis Fungoides Manifesting as Giant Cell Lichenoid Dermatitis.
The American Journal of dermatopathology[Diagnostics of primary cutaneous lymphomas].
Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte GebieteBrentuximab vedotin in CD30+ primary cutaneous T-cell lymphomas: a review and analysis of existing data.
International journal of dermatologyCutaneous Lymphomas with Cytotoxic Phenotype.
Surgical pathology clinicsRenaissance of Low-Dose Radiotherapy Concepts for Cutaneous Lymphomas.
Oncology research and treatmentAEDV Primary Cutaneous Lymphoma Registry.
Actas dermo-sifiliograficasA 92-year-old man with primary cutaneous diffuse large B-cell non-Hodgkin's lymphoma manifesting as a giant scalp mass: A case report.
MedicinePrimary cutaneous non-Hodgkin lymphoma: results of a retrospective analysis in the light of the recent ILROG guidelines.
TumoriAggressive cutaneous T-cell lymphomas.
Seminars in diagnostic pathologyThe role of 18F-FDG PET and PET/CT in the evaluation of primary cutaneous lymphoma.
Nuclear medicine communicationsParaneoplastic Dermatosis in a Patient with Anaplastic Large-Cell Lymphoma: Case Report and Literature Review.
Dermatopathology (Basel, Switzerland)Mechanism, Consequences, and Therapeutic Targeting of Abnormal IL15 Signaling in Cutaneous T-cell Lymphoma.
Cancer discoveryImportance of assessing nonattenuation-corrected positron emission tomography images in treatment response evaluation of primary cutaneous lymphoma.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaDiagnosing Spindle Cell Variant of Primary Cutaneous B-Cell Lymphoma: Potential Pitfalls and Solutions.
Annals of clinical and laboratory scienceAdolescent weight and height are predictors of specific non-Hodgkin lymphoma subtypes among a cohort of 2,352,988 individuals aged 16 to 19 years.
CancerPrimary cutaneous lymphomas: diagnosis and treatment.
Postepy dermatologii i alergologiiPrimary Cutaneous Lymphoma-Associated Pseudoepitheliomatous Hyperplasia Masquerading as Squamous Cell Carcinoma in a Young Adult.
Acta medica IranicaPrimary cutaneous lymphoma in southern Brazil: a 12-year single-center experience.
International journal of dermatologyDiagnosis and Management of Cutaneous B-cell Lymphoma.
Dermatologic clinicsEvaluation, Diagnosis, and Staging of Cutaneous Lymphoma.
Dermatologic clinicsIllness Perception in Primary Cutaneous T-cell Lymphomas: What Patients Believe About Their Disease.
Acta dermato-venereologicaGalectin-3 Expression in Primary Cutaneous CD30-Positive Lymphoproliferative Disorders and Transformed Mycosis Fungoides.
Dermatology (Basel, Switzerland)Primary cutaneous natural killer/T-cell lymphoma of the nasal type: a report of 4 cases in North American patients.
Annals of diagnostic pathologySixty years old man with primary cutaneous lymphoma.
Mymensingh medical journal : MMJBest practices in diagnostic immunohistochemistry: workup of cutaneous lymphoid lesions in the diagnosis of primary cutaneous lymphoma.
Archives of pathology & laboratory medicineFrequency of primary cutaneous lymphoma variants in Austria: retrospective data from a dermatology referral centre between 2006 and 2013.
Journal of the European Academy of Dermatology and Venereology : JEADVAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Primary Cutaneous Follicle Center Lymphoma of the Nasal Dorsum and Tip Treated by Surgical Excision and Full-Thickness Skin Graft Reconstruction: A Case Report.
- Primary Cutaneous Lymphomas in Children: A Case Series Review with Emphasis on Diagnostic Imaging and Multidisciplinary Management.
- Haematopoietic stem cell transplant in cutaneous T-cell lymphomas: A multicentre propensity-score matched study.Journal of the European Academy of Dermatology and Venereology : JEADV· 2026· PMID 40065681mais citado
- Clinical Warburg Effect in a primary cutaneous lymphoma.
- [Recent Research Advances in Classification and Treatment of Primary Cutaneous Lymphoma--Review].
- Moderate-Dose Local Radiotherapy in Symptomatic CD30-Positive, Anaplastic Lymphoma Kinase (ALK)-Negative Primary Cutaneous T-cell Lymphoma.
- Acalabrutinib treatment in relapsed/refractory primary cutaneous diffuse large B cell lymphoma, leg type. Case report.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:542(Orphanet)
- MONDO:0018898(MONDO)
- GARD:18698(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q1794643(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
