Os anticorpos (Ac) são glicoproteínas do tipo gamaglobulina, a fracção de globulinas mais abundante no plasma sanguíneo. Podem encontrar-se em forma solúvel no sangue ou noutros fluídos corporais dos vertebrados, ou podem estar inseridos na membrana plasmática, onde actuam como receptores nos linfócitos B e são empregues pelo sistema imunitário para neutralizar patógenos tais como bactérias patogénicas e viroses. Em geral, considera-se que tanto anticorpo como imunoglobulina são termos equivalentes, sendo que o primeiro termo faz referência à função, enquanto que o segundo alude à estrutura.
Introdução
O que você precisa saber de cara
Tumores associados ao EBV incluem linfomas de células B (como Burkitt) e carcinomas. Podem manifestar-se com derrames (pleural, pericárdico), distensão abdominal e anormalidades hepáticas, frequentemente em contextos de imunodeficiência.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 20 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 57 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
3 genes identificados com associação a esta condição.
Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3' (PubMed:24940000, PubMed:25956029). Activates the transcription of growth-related genes (PubMed:24940000, PubMed:25956029). Binds to the VEGFA promoter, promoting VEGFA production and subsequent sprouting angiogenesis (PubMed:24940000, PubMed:25956029). Regulator of somatic reprogramming, controls self-renewal of embryonic stem cells (By similarity). Functions with TAF
Nucleus, nucleoplasmNucleus, nucleolusNucleusCytoplasmChromosome
Inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL (RELA/p65 and NFKB1/p50) dimers in the cytoplasm by masking their nuclear localization signals (PubMed:1493333, PubMed:36651806, PubMed:7479976). On cellular stimulation by immune and pro-inflammatory responses, becomes phosphorylated promoting ubiquitination and degradation, enabling the dimeric RELA to translocate to the nucleus and activate transcription (PubMed:7479976, PubMed:7628694, PubMed:7796813, PubMed:7878466)
CytoplasmNucleus
Ectodermal dysplasia and immunodeficiency 2
A form of ectoderma dysplasia, a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. This form of ectodermal dysplasia is associated with decreased production of pro-inflammatory cytokines and certain interferons, rendering patients susceptible to infection. EDAID2 inheritance is autosomal dominant.
Involved in pinching off the separated nuclei at the cleavage furrow and in cytokinesis (PubMed:20107318). Required for mitotic integrity and maintenance of chromosomal stability. Protects cells against mitotic errors, centrosomal amplification, micronucleus formation and aneuploidy. Plays a key role of midbody function involving abscission of the daughter cells during cytokinesis and appropriate chromosomal and nuclear segregation into the daughter cells (PubMed:22988245, PubMed:23713010)
CytoplasmMidbody
Lymphoma, Hodgkin, classic
A malignant disease characterized by progressive enlargement of the lymph nodes, spleen and general lymphoid tissue, and the presence of large, usually multinucleate, cells (Reed-Sternberg cells). Reed-Sternberg cells compose only 1-2% of the total tumor cell mass. The remainder is composed of a variety of reactive, mixed inflammatory cells consisting of lymphocytes, plasma cells, neutrophils, eosinophils and histiocytes.
Variantes genéticas (ClinVar)
131 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
33 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Tumor relacionado com vírus Epstein-Barr
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Pesquisa e ensaios clínicos
Nenhum ensaio clínico registrado para esta condição.
Publicações mais relevantes
The potential of real-time dynamic disease monitoring with circulating tumor DNA: important lessons from Epstein-Barr virus-related nasopharyngeal carcinoma.
[New mechanisms and therapeutic targets for viral tumors].
Virus-related cancers remain a notable subset of all cancers, and many are still difficult to control, despite the fact that most infectious diseases other than emerging infectious ones can now be controlled. Among these, Epstein-Barr virus (EBV)-associated cancers, which are less common in the West and more common in East Asia, have a particularly poor prognosis. Due to the low frequency of EBV-associated cancers in Europe and the United States, little progress has been made in research and development for new drugs specific to these cancers, making drugs from East Asia essential for improving prognosis. This article focuses on EBV-associated cancers of hematopoietic origin, and describes the current status of various novel therapies, as well as the anti-transferrin antibody for aggressive NK leukemia developed by the author.
[Malignant neoplasms and transplantation].
Malignant neoplasms constitute a major burden of morbidity and mortality in the general population. This necessitates intense screening of transplant candidates and even closer surveillance of immunosuppressed solid organ recipients. Active malignancy is an exclusion criterion to solid organ transplantation, with few exceptions, namely localized hepatic neoplasms. Accelerated tumor progression characterizes post-transplantation malignancies. Intensified surveillance is justified in elevated rates, e.g., of skin cancer and virus-associated neoplasms, especially Epstein-Barr virus-associated post-transplantation lymphoproliferative disease (PTLD). Renal cell cancer rates rise after kidney transplantation, predominantly affecting the native kidneys. Chemotherapeutic dose adjustments for renal and hepatic function pharmacokinetic interactions are frequent and require active monitoring. Immunotherapies pose new challenges by induction of allograft rejection. Data on management of immunosuppression are emerging. Individualized concepts need to take into account therapeutic options of both anti-cancer therapy and organ replacement. Malignome als insgesamt zweithäufigste Todesursache spielen auch bei Transplantationskandidaten und nach Transplantation eine große Rolle. Ein ausreichender Malignomausschluss vor der Transplantation verbessert die Sicherheit der Immunsuppression. In einzelnen Fällen kann die Transplantation der Leber allerdings auch Mittel der Tumortherapie sein. Nach einer Transplantation ist eine intensivierte Tumorvorsorge notwendig. Dabei sind nach der Transplantation nichtmelanomatöse Hauttumoren extrem häufig. Typischerweise und relativ zur Allgemeinbevölkerung steigt vor allem das Risiko virusbedingter Tumoren. Hier ist wegen der signifikanten Mortalität die lymphoproliferative Erkrankung nach Transplantation hervorzuheben, die mit dem Epstein-Barr-Virus assoziiert ist. Nach Nierentransplantation sind Nierenzellkarzinome, insbesondere der Eigennieren, überzufällig häufig. Chemotherapeutikadosierungen müssen an die Leber- und Nierenfunktion angepasst werden, gerade bei neueren Substanzen sind mögliche Arzneimittelinteraktionen mit hoher Aufmerksamkeit zu recherchieren. Die bei vielen Tumorentitäten erfolgreichen Immuntherapien sind nach Organtransplantation eine große Herausforderung, da sie regelhaft auch eine Immunreaktion gegen das Transplantat hervorrufen. Hier muss individuell entschieden werden, auch danach, ob das Transplantat lebenserhaltend ist oder gegebenenfalls durch Dialyse ersetzt werden kann.
Impact of Antibody Immune Response and Immune Cells on Osteoporosis and Fractures.
The immune system plays a critical role in the development and progression of osteoporosis and fractures. However, the causal relationships between antibody immune responses, immune cells, and these bone conditions remain unclear. This study aimed to explore these relationships using Mendelian randomization (MR) analysis. We collected complete blood count data from patients with fractures and healthy individuals and analyzed their differences. Then, we conducted a 2-sample, 2-step MR analysis to investigate the causal effects of antibody immune responses on osteoporosis and fractures, using inverse-variance weighted (IVW) as the primary method. We also explored whether immune cells mediate the pathway between antibodies and osteoporosis or fractures. Finally, we analyzed the functions and expression levels of key genes involved. Overall, the fracture group exhibited increased white blood cell count, absolute neutrophil count, absolute monocyte count, platelet count, and their respective proportions, while absolute lymphocyte count, absolute eosinophil count, absolute basophil count, red blood cell count, and their proportions were decreased. We identified 44 causal relationships between antibodies and osteoporosis or fractures, with 7 supported by multiple MR methods, and 5 showing odds ratios significantly deviating from 1 in the IVW analysis. Epstein-Barr virus-related antibodies had a notable impact on osteoporosis and fractures. The human leukocyte antigen (HLA) gene family, particularly HLA-DPB1, emerged as a significant risk factor. However, immune cells were not found to mediate these effects. This study elucidated the causal relationships between antibody immune responses, immune cells, and osteoporosis or fractures. The HLA gene family plays a crucial role in the interaction between antibodies and these bone conditions, with HLA-DPB1 identified as a key risk gene. Immune cells do not serve as mediators in this process. These findings provide valuable insights for future research.
Clinical features and risk factors for Epstein-Barr virus-associated encephalitis: a retrospective cohort study.
Epstein-Barr virus (EBV) has been gradually recognized as an important pathogen of encephalitis, but our knowledge of EBV-associated encephalitis is still limited. The aim of this study was to describe the clinical features and explore the risk factors for EBV-associated encephalitis in a large cohort of Chinese patients. All patients with confirmed encephalitis in our center from June 2020 to April 2021 were enrolled. Data were extracted from the electronic medical record system and analyzed by Student's t test, Mann-Whitney U test, chi-square test, and logistic regression analyses. This study included a total of 364 patients diagnosed with encephalitis, among which 86 cases (23.6%) had EBV detected in their cerebrospinal fluid (CSF), and 39 cases were diagnosed with EBV-associated encephalitis. The clinical characteristics of EBV-associated encephalitis differ from those caused by other herpes viruses. Compared to other herpes virus-related encephalitis, patients with EBV encephalitis exhibited significantly higher protein levels (1.310 [0.695, 1.840] vs. 0.710 [0.490, 1.700], p < 0.001), lower glucose levels (3.030 [2.585, 3.640] vs. 3.380 [2.990, 4.030], p < 0.001), and a higher incidence of meningeal involvement on MRI (11 (30.6%) vs. 3 (6.5%), p = 0.010). Additionally, univariate logistic regression analysis revealed that age (OR = 1.015, 95% CI: 1.002-1.029), HIV infection (OR = 4.285, 95% CI: 1.582-11.816), non-tumor immunosuppression (OR = 5.713, 95% CI: 1.588-22.883), and peripheral blood EBV infection (OR = 10.204, 95% CI: 4.231-26.346) were independent risk factors for CNS EBV infection. Compared to other herpes virus-associated encephalitis, EBV encephalitis is characterized by a higher degree of meningeal involvement, elevated CSF protein levels, lower glucose levels, and a reduced T-lymphocyte count in peripheral blood. These characteristics suggest that EBV encephalitis may have a distinct pathophysiology.
Publicações recentes
Catastrophic ENT Complications of Pediatric Infectious Mononucleosis: Recent Experience at a Tertiary Pediatric Hospital.
Development of a Diagnostic Autoantibody Assay to a Consensus Motif for the Risk Prediction of Epstein-Barr Virus-Related Multiple Sclerosis.
A multi-glycoprotein synergized recombinant virus system resolved the research dilemma of Epstein-Barr virus entry and facilitated the development of entry-specific drugs or vaccines.
Clarifying the Diagnosis of Epstein-Barr Virus Related Myositis in a Genetically Confirmed Mitochondrial Diabetes Patient.
Relationship between Epstein-Barr virus and inflammatory bowel disease.
📚 EuropePMCmostrando 118
[New mechanisms and therapeutic targets for viral tumors].
[Rinsho ketsueki] The Japanese journal of clinical hematology[Malignant neoplasms and transplantation].
Innere Medizin (Heidelberg, Germany)Impact of Antibody Immune Response and Immune Cells on Osteoporosis and Fractures.
Clinics in orthopedic surgeryClinical features and risk factors for Epstein-Barr virus-associated encephalitis: a retrospective cohort study.
Virology journalViral oncogenesis in cancer: from mechanisms to therapeutics.
Signal transduction and targeted therapyThe critical role of ferroptosis in virus-associated hematologic malignancies and its potential value in antiviral-antitumor therapy.
VirulenceConcomitant Splenic Tuberculosis and Epstein-Barr Virus-Related T-Cell Leukemia/Lymphoma in a 28-Year-Old Pregnant Woman in South Sudan.
The American journal of tropical medicine and hygieneThe potential of real-time dynamic disease monitoring with circulating tumor DNA: important lessons from Epstein-Barr virus-related nasopharyngeal carcinoma.
The Lancet regional health. Western PacificAnti-Epstein-Barr Virus Activities of Flavones and Flavonols with Effects on Virus-Related Cancers.
Molecules (Basel, Switzerland)Vaccine-Based Immunotherapy for Oropharyngeal and Nasopharyngeal Cancers.
Journal of clinical medicineThe Role of Viruses in Cellular Transformation and Cancer.
Cancer reports (Hoboken, N.J.)Excess Mortality in Persons with Concurrent HIV and Cancer Diagnoses: A Retrospective Cohort Study.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive OncologyUnveiling the Impact of Epstein-Barr Virus on the Risk of Prostate Cancer: A Mendelian Randomization Study.
Nutrition and cancerApplications of cell therapy in the treatment of virus-associated cancers.
Nature reviews. Clinical oncologySerum NF-κB in Epstein-Barr Virus-Related Oropharyngeal Carcinoma Diagnostic Usability.
CancersVitamin D and viral infections: Infectious diseases, autoimmune diseases, and cancers.
Advances in food and nutrition researchEpstein-Barr-Virus-Related Lymphoproliferative Disorder in a Patient With Primary Myelofibrosis: A Case Report and Literature Review.
CureusRefining the 8th edition TNM classification for EBV related nasopharyngeal carcinoma.
Cancer cellMYH9: A key protein involved in tumor progression and virus-related diseases.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieDiabetes can increase the prevalence of EBV infection and worsen the prognosis of nasopharyngeal carcinoma.
PathologySequence variation of the Epstein-Barr virus nuclear antigen 1 (EBNA1) gene in chronic lymphocytic leukemia and healthy volunteer subjects.
Archives of virologyClinicopathological features of a rare cancer: Intrahepatic lymphoepithelioma-like cholangiocarcinoma with Epstein-Barr virus infection.
Clinics and research in hepatology and gastroenterologySecond-line chemoimmunotherapy with nivolumab and paclitaxel in immune-related biomarker-enriched advanced gastric cancer: a multicenter phase Ib/II study.
Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer AssociationOpen-Label, Multicenter, Randomized, Biomarker-Integrated Umbrella Trial for Second-Line Treatment of Advanced Gastric Cancer: K-Umbrella Gastric Cancer Study.
Journal of clinical oncology : official journal of the American Society of Clinical OncologyTreatment Options for Epstein-Barr Virus-Related Disorders of the Central Nervous System.
Infection and drug resistance[A case of Epstein-Barr virus-related smooth muscle tumor secondary to Wiskott-Aldrich syndrome treated by allogeneic hematopoietic stem cell transplantation].
Zhonghua er ke za zhi = Chinese journal of pediatricsOutcomes of programmed death protein-1 inhibitors treatment of chronic active Epstein Barr virus infection: A single center retrospective analysis.
Frontiers in immunology[Chinese consensus on the diagnosis and management of Epstein-Barr virus-related post-transplant lymphoproliferative disorders after hematopoietic stem cell transplantation (2022)].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiTop advances of the year: Head and neck cancer.
CancerHigh-dose extended-field radiotherapy plus chemotherapy improved survival in extranodal NK/T-cell lymphoma in a real-life setting: results from the multicenter T-Cell Brazil Project.
Scientific reportsCombining Epstein-Barr virus antibodies for early detection of nasopharyngeal carcinoma: A meta-analysis.
Auris, nasus, larynxTreatment of Epstein-Barr Virus-Related Post-Renal Transplantation Development of Diffuse Large B Cell Lymphoma of the Distal Ureter: A Case Report.
Transplantation proceedingsCancer of the nasopharynx in Aotearoa New Zealand from 1994 to 2018: Incidence and survival in a population-based, national registry cohort study.
The Lancet regional health. Western PacificLong non-coding RNAs in virus-related cancers.
Reviews in medical virologyCritical involvement of circular RNAs in virus-associated cancers.
Genes & diseasesEpstein-Barr virus-related diffuse large B-cell lymphoma type methotrexate-associated lymphoproliferative disorders presenting in the adrenal gland.
IJU case reportsLymphoma-based therapy for refractory or relapsed Epstein-Barr virus-related hemophagocytic lymphohistiocytosis in children.
Journal of the Formosan Medical Association = Taiwan yi zhiRenal cell carcinoma and viral infections: A dangerous relationship?
World journal of nephrologyThe Distribution of M2 Macrophage and Treg in Nasopharyngeal Carcinoma Tumor Tissue and the Correlation with TNM Status and Clinical Stage.
Asian Pacific journal of cancer prevention : APJCPSingle-Cell RNAseq Profiling of Human γδ T Lymphocytes in Virus-Related Cancers and COVID-19 Disease.
VirusesNext-Generation Sequencing as an Auxiliary Tool in Pediatric Laryngeal Lymphoma Diagnosis.
PediatricsEstimating the global burden of Epstein-Barr virus-related cancers.
Journal of cancer research and clinical oncologyIncidence of malignancy after pediatric kidney transplantation: a single-center experience over the past three decades in Japan.
Clinical and experimental nephrologyAssessment of Survival Model Performance Following Inclusion of Epstein-Barr Virus DNA Status in Conventional TNM Staging Groups in Epstein-Barr Virus-Related Nasopharyngeal Carcinoma.
JAMA network open[Epstein-Barr virus-associated smooth muscle tumor in a girl].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsVirus-Driven Carcinogenesis.
CancersLong non-coding RNAs in Epstein-Barr virus-related cancer.
Cancer cell internationalEpstein-Barr virus-related lymphoma in rheumatoid arthritis: implications for long-term usage of immunosuppressive drugs and review of the literature.
Internal medicine journalEpstein-Barr Virus-associated Diffuse Large B-cell Lymphoma Identified in a Breast Implant Capsule: A New Breast Implant-Associated Lymphoma?
Annals of plastic surgeryMultiple small tumor formation on both surfaces of the aortic valve cusps in Epstein-Barr virus-associated T/NK-cell lymphoproliferative disease: a case report.
General thoracic and cardiovascular surgeryAdoptive T-Cell Therapy for Epstein-Barr Virus-Related Lymphomas.
Journal of clinical oncology : official journal of the American Society of Clinical OncologyAnti-TIF1γ antibody-positive dermatomyositis in a 15-year-old boy with Epstein-Barr virus-related nasopharyngeal cancer receiving nivolumab.
Rheumatology (Oxford, England)Orbital Epstein-Barr virus-related post-transplant lymphoproliferative disorder in a 13-year-old girl with cord blood transplantation.
Transplant infectious disease : an official journal of the Transplantation SocietyPlasma Macrophage Inhibitory Cytokine-1 as a Complement of Epstein-Barr Virus Related Markers in Identifying Nasopharyngeal Carcinoma.
Technology in cancer research & treatmentQuantitative proteomics reveals a broad-spectrum antiviral property of ivermectin, benefiting for COVID-19 treatment.
Journal of cellular physiologySelect Epstein-Barr Virus-Associated Digestive Tract Lesions for the Practicing Pathologist.
Archives of pathology & laboratory medicineManagement of older Hodgkin lymphoma patients.
Hematology. American Society of Hematology. Education ProgramDisseminated Gastrointestinal and Hepatosplenic Epstein-Barr Virus-related Smooth Muscle Tumors in a Young Heart-transplant Recipient.
Journal of pediatric gastroenterology and nutritionDistant Metastasis Risk Definition by Tumor Biomarkers Integrated Nomogram Approach for Locally Advanced Nasopharyngeal Carcinoma.
Cancer control : journal of the Moffitt Cancer CenterIncreasing incidence of Epstein-Barr virus-related nasopharyngeal carcinoma in the United States.
CancerDefining signatures of peripheral T-cell lymphoma with a targeted 20-marker gene expression profiling assay.
HaematologicaAnti-Cancer Mechanisms of Taurine in Human Nasopharyngeal Carcinoma Cells.
Advances in experimental medicine and biologyEpstein-Barr Virus-related Multi-site Mucocutaneous Ulcer: A Previously Undescribed Clinical Subset of a Rare Disease.
Acta dermato-venereologicaMolecular Decision Tree Algorithms Predict Individual Recurrence Pattern for Locally Advanced Nasopharyngeal Carcinoma.
Journal of Cancer[Genetic Alterations Involving PD-L1/PD-L2 in Human Malignancies].
Gan to kagaku ryoho. Cancer & chemotherapyImmune checkpoint inhibitors in the treatment of virus-associated cancers.
Journal of hematology & oncologyCharacterization of Viral Infections after Antithymocyte Globulin-Based Conditioning in Adults Undergoing Allogeneic Hematopoietic Stem Cell Transplantation.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow TransplantationEpstein-Barr virus and its association with disease - a review of relevance to general practice.
BMC family practiceA Rare Case of Activated Phosphoinositide 3-Kinase Delta Syndrome (APDS) Presenting With Hemophagocytosis Complicated With Hodgkin Lymphoma.
Journal of pediatric hematology/oncologyNon-Hodgkin Lymphoma in the Middle East Is Characterized by Low Incidence Rates With Advancing Age.
Journal of global oncologyDynamic host immune response in virus-associated cancers.
Communications biologyPrimary hepatic leiomyosarcoma successfully treated by transcatheter arterial chemoembolization: A case report.
World journal of clinical casesInvestigation of three oncogenic epitheliotropic viruses shows human papillomavirus in association with non-melanoma skin cancer.
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical MicrobiologyRole of Epstein-Barr Virus and Human Papillomavirus Coinfection in Oral and Anogenital Carcinogenesis: Potential Tumorigenic Pathways.
Critical reviews in oncogenesisEpstein-Barr virus-related diffuse large B-cell lymphoma in mogamulizumab-treated adult T-cell leukemia with incomplete T-cell reconstitution.
International journal of hematologyProposed modifications and incorporation of plasma Epstein-Barr virus DNA improve the TNM staging system for Epstein-Barr virus-related nasopharyngeal carcinoma.
CancerAn integrated automated multispectral imaging technique that simultaneously detects and quantitates viral RNA and immune cell protein markers in fixed sections from Epstein-Barr virus-related tumours.
Annals of diagnostic pathologyUtility of Epstein-Barr Virus Biomarkers in Human Immunodeficiency Virus-related Lymphomas in the Modern Combined Antiretroviral Therapy Era.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America[iPSC-derived rejuvenated T-cell therapy for Epstein-Barr virus-associated lymphomas].
[Rinsho ketsueki] The Japanese journal of clinical hematologyPlasma Epstein-Barr Virus Load as an Early Biomarker and Prognostic Factor of Human Immunodeficiency Virus-related Lymphomas.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaDeregulation of the Notch pathway as a common road in viral carcinogenesis.
Reviews in medical virologyInterleukin-2-Inducible T-Cell Kinase Deficiency-New Patients, New Insight?
Frontiers in immunologyEpstein-Barr virus-specific cytokine-induced killer cells for treatment of Epstein-Barr virus-related malignant lymphoma.
CytotherapyAdalimumab-Induced Epstein-Barr Virus-Related Lymphoproliferative Disorder on FDG PET/CT.
Clinical nuclear medicineA case of Epstein-Barr virus-negative human immunodeficiency virus-related primary effusion lymphoma.
Journal of infection and chemotherapy : official journal of the Japan Society of ChemotherapyChildhood Nasopharyngeal Carcinoma: State-of-the-Art, and Questions for the Future.
Journal of pediatric hematology/oncologyAn inflammatory myofibroblastic tumor in the transplanted liver displaying quick wash-in and wash-out on contrast-enhanced ultrasound: A case report.
MedicineSetting the Stage for 2018: How the Changes in the American Joint Committee on Cancer/Union for International Cancer Control Cancer Staging Manual Eighth Edition Impact Radiologists.
AJNR. American journal of neuroradiologyDevelopment of Epstein-Barr Virus-related Primary Diffuse Large B-cell Lymphoma of the Central Nervous System in a Patient with Peripheral T-cell Lymphoma, Not Otherwise Specified after Mogamulizumab Treatment.
Internal medicine (Tokyo, Japan)The 150 most important questions in cancer research and clinical oncology series: questions 31-39 : Edited by Chinese Journal of Cancer.
Chinese journal of cancerBarriers to generating PDX models of HPV-related head and neck cancer.
The LaryngoscopePathogenesis and FDG-PET/CT findings of Epstein-Barr virus-related lymphoid neoplasms.
Annals of nuclear medicineTreatment of Primary Central Nervous System Posttransplant Lymphoproliferative Disorder in an Adult Kidney Transplant Recipient: A Case Report.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ TransplantationConjunctival tumor caused by Epstein-Barr virus-related infectious mononucleosis: Case report and review of literature.
Orbit (Amsterdam, Netherlands)[Expression of long non-coding RNA SNHG8 in Epstein-Barr virus-related gastric cancer and clinical outcome].
Zhonghua bing li xue za zhi = Chinese journal of pathologyWhat Should Be Done in Inflammatory Bowel Disease Patients with Prior Malignancy?
Digestive diseases (Basel, Switzerland)Epstein-Barr-virus-related mucocutaneous ulceration that mimics oral squamous cell carcinoma: the importance of recognising this new condition.
The British journal of oral & maxillofacial surgeryResolution of Multifocal Epstein-Barr Virus-Related Smooth Muscle Tumor in a Patient with GATA2 Deficiency Following Hematopoietic Stem Cell Transplantation.
Journal of clinical immunologyHLA-mismatched haploidentical transplantation using low-dose anti-thymocyte globulin (ATG: thymoglobulin).
Hematology (Amsterdam, Netherlands)[Primary central nervous system diffuse large B cell lymphoma: a clinicopathologic and molecular study].
Zhonghua bing li xue za zhi = Chinese journal of pathologyPotential Interest in Circulating miR-BART17-5p As a Post-Treatment Biomarker for Prediction of Recurrence in Epstein-Barr Virus-Related Nasopharyngeal Carcinoma.
PloS oneLymphoma Secondary to Congenital and Acquired Immunodeficiency Syndromes at a Turkish Pediatric Oncology Center.
Journal of clinical immunologyFacial manifestations of Epstein-Barr virus-related lymphoproliferative disease in childhood acute lymphoblastic leukemia in remission: Two atypical presentations.
Pediatric blood & cancerThe epithelial-mesenchymal transition (EMT) is regulated by oncoviruses in cancer.
FASEB journal : official publication of the Federation of American Societies for Experimental BiologyAssociation of DDX58 177 C > T polymorphism with decreased risk of Epstein-Barr virus-related nodular sclerosis classical Hodgkin lymphoma.
Leukemia & lymphomaSpontaneous Regression of Pulmonary Nodules Presenting as Epstein-Barr Virus-related Atypical Infectious Mononucleosis.
Journal of pediatric hematology/oncologyGastric adenocarcinoma microRNA profiles in fixed tissue and in plasma reveal cancer-associated and Epstein-Barr virus-related expression patterns.
Laboratory investigation; a journal of technical methods and pathologySuccessful management of EBV-PTLD in allogeneic bone marrow transplant recipient by virological-immunological monitoring of EBV infection, prompt diagnosis and early treatment.
Transplant immunologyNovel targets for natural killer/T-cell lymphoma immunotherapy.
ImmunotherapyEpstein-Barr Virus-associated lymphoproliferative disorders: experimental and clinical developments.
International journal of clinical and experimental medicineBanked Donor T-Cells Treat Virus-Related B Cell Disorder when Rituximab Fails.
Journal of the National Cancer InstituteHPV and EBV Infections in Neck Metastases from Occult Primary Squamous Cell Carcinoma: Another Virus-Related Neoplastic Disease in the Head and Neck Region.
Annals of surgical oncologyEpstein-Barr Virus-Related Post-Transplantation Lymphoproliferative Disorder after Unmanipulated Human Leukocyte Antigen Haploidentical Hematopoietic Stem Cell Transplantation: Incidence, Risk Factors, Treatment, and Clinical Outcomes.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow TransplantationEpstein-Barr virus infection and nasopharyngeal carcinoma: the other side of the coin.
Anti-cancer drugsLate-onset Epstein-Barr virus-related disease in acute leukemia patients after haploidentical hematopoietic stem cell transplantation is associated with impaired early recovery of T and B lymphocytes.
Clinical transplantationPrimary cutaneous natural killer/T-cell lymphoma of the nasal type: a report of 4 cases in North American patients.
Annals of diagnostic pathologyImpact of Epstein Barr virus-related complications after high-risk allo-SCT in the era of pre-emptive rituximab.
Bone marrow transplantationSecondary Malignant Neoplasms Following Haematopoietic Stem Cell Transplantation in Childhood.
Children (Basel, Switzerland)Associações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- The potential of real-time dynamic disease monitoring with circulating tumor DNA: important lessons from Epstein-Barr virus-related nasopharyngeal carcinoma.
- [New mechanisms and therapeutic targets for viral tumors].
- [Malignant neoplasms and transplantation].
- Impact of Antibody Immune Response and Immune Cells on Osteoporosis and Fractures.
- Clinical features and risk factors for Epstein-Barr virus-associated encephalitis: a retrospective cohort study.
- Catastrophic ENT Complications of Pediatric Infectious Mononucleosis: Recent Experience at a Tertiary Pediatric Hospital.
- Development of a Diagnostic Autoantibody Assay to a Consensus Motif for the Risk Prediction of Epstein-Barr Virus-Related Multiple Sclerosis.
- A multi-glycoprotein synergized recombinant virus system resolved the research dilemma of Epstein-Barr virus entry and facilitated the development of entry-specific drugs or vaccines.
- Clarifying the Diagnosis of Epstein-Barr Virus Related Myositis in a Genetically Confirmed Mitochondrial Diabetes Patient.
- Relationship between Epstein-Barr virus and inflammatory bowel disease.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:289638(Orphanet)
- MONDO:0017342(MONDO)
- GARD:21146(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q55786996(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
