Raras
Buscar doenças, sintomas, genes...
Encefalite japonesa
ORPHA:79139CID-10 · A83.0CID-11 · 1C85DOENÇA RARA

Uma doença causada por um vírus transmitido por um artrópode.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Uma doença causada por um vírus transmitido por um artrópode.

Pesquisas ativas
5 ensaios
84 total registrados no ClinicalTrials.gov
Publicações científicas
6.421 artigos
Último publicado: 2026 Jun

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: A83.0
Você se identifica com essa condição?
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
15 sintomas
💪
Músculos
9 sintomas
🫁
Pulmão
5 sintomas
🫃
Digestivo
3 sintomas
😀
Face
3 sintomas
👁️
Olhos
3 sintomas

+ 40 sintomas em outras categorias

Características mais comuns

90%prev.
Febre
Muito frequente (99-80%)
90%prev.
Anormalidade no EEG
Muito frequente (99-80%)
90%prev.
Encefalite infecciosa
Muito frequente (99-80%)
55%prev.
Fraqueza devido à disfunção do neurônio motor superior
Frequente (79-30%)
55%prev.
Consciência/confusão reduzida
Frequente (79-30%)
55%prev.
Atrofia do músculo esquelético
Frequente (79-30%)
83sintomas
Muito frequente (3)
Frequente (28)
Ocasional (51)
Sem dados (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 83 características clínicas mais associadas, ordenadas por frequência.

FebreFever
Muito frequente (99-80%)90%
Anormalidade no EEGEEG abnormality
Muito frequente (99-80%)90%
Encefalite infecciosaInfectious encephalitis
Muito frequente (99-80%)90%
Fraqueza devido à disfunção do neurônio motor superiorWeakness due to upper motor neuron dysfunction
Frequente (79-30%)55%
Consciência/confusão reduzidaReduced consciousness/confusion
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico6.421PubMed
Últimos 10 anos200publicações
Pico2025119 papers
Linha do tempo
2026Hoje · 2026🧪 2002Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado5
3Fase 38
2Fase 22
·Pré-clínico5
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Encefalite japonesa

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

2 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

84 ensaios clínicos encontrados, 5 ativos.

Distribuição por fase
NCT06825312 · Immunogenicity, Safety, and Antibody Persistence of Differen…Ativo
PHASE4
NCT06678373 · Monitoring JE Antibody Levels in Healthy Populations and Imm…Ativo
PHASE4
NCT06674837 · Diagnostics and Surveillance of Acute Meningo-encephalitis A…Em breve
NCT06331702 · Immunogenicity of Japanese Encephalitis Vaccine Co-administe…Concluído
PHASE4
NCT06372665 · Safety Observation of the Japanese Encephalitis Vaccine Give…Concluído
NCT03920111 · Flavivirus Cross-priming Potential of IMOJEVConcluído
NA
NCT00594958 · Comparison of Three Batches of the Japanese Encephalitis Vac…Concluído
PHASE3
NCT00605085 · Safety and Tolerability of the Japanese Encephalitis Vaccine…Concluído
PHASE3
NCT00604708 · Immunogenicity Study of the Japanese Encephalitis Vaccine IC…Concluído
PHASE3
NCT05568953 · An Experimental Medicine Decipher of a Minimum Correlate of …UNKNOWN
PHASE2
NCT04817917 · Seroprevalence of Neutralizing Antibodies Against Japanese E…UNKNOWN
PHASE4
NCT02933710 · Postmarketing Surveillance Study for IMOJEV® in Republic of …Concluído
NCT01900444 · Study of a Booster Dose of IMOJEV® One Year After Primary Im…Concluído
PHASE3
NCT02492165 · Study of a Single Primary Dose Live Attenuated Japanese Ence…Concluído
PHASE3
NCT01190228 · Study of Japanese Encephalitis Chimeric Virus Vaccine (JE-CV…Concluído
PHASE3
NCT04223037 · Purified Inactivated Japanese Encephalitis VaccineUNKNOWN
PHASE3
NCT01041573 · Safety and Immunogenicity of the Japanese Encephalitis Vacci…Concluído
PHASE3
NCT02514746 · Long-term Immunogenicity After Receipt of JE Vaccine and Ant…Concluído
PHASE4
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
2.773 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 2.773

#1

Inactivated Japanese encephalitis virus vaccination imprints fusion loop-biased antibody responses that are attenuated by repeated live-attenuated dengue vaccination.

medRxiv : the preprint server for health sciences2026 Mar 02

Immune imprinting, also known as immune history, is a core aspect of adaptive immunity that influences antibody responses to future antigen exposures. Nevertheless, the impact of sequential flavivirus vaccinations on epitope targeting and antibody activity in humans remains incompletely understood. This question is particularly important in regions where the inactivated Japanese encephalitis virus (JEV) vaccines and the live-attenuated dengue virus (DENV) vaccines are used, as both have been associated with an increased risk of symptomatic dengue infection and severe illness. We studied the impact of prior inactivated JEV IXIARO vaccination and simultaneous vaccination on humoral immunity following live-attenuated dengue CYD-TDV vaccination. Long-term analysis showed that JEV IXIARO priming guides the dengue vaccine-induced antibody response toward conserved fusion loop epitopes (FLEs) of the DENV envelope protein, as indicated by 4G2 FLE-bias. This imprinting was characterized by higher levels of 4G2 FLE-like antibodies, rapid recall responses after dengue vaccination, and broad but low-potency neutralization across dengue serotypes and Zika virus. Notably, 4G2 FLE-focused responses correlated with higher FcγRIIa-mediated antibody-dependent enhancement relative to neutralization potency, suggesting functional effects beyond neutralization. To better understand epitope dominance within the native envelope, we used a structurally defined fusion loop epitope mutant (FLE-mut) envelope dimer assay. Disrupting fusion loop accessibility significantly decreased antibody binding, confirming that FLE-specific antibodies are a major component of the response after sequential vaccination. Importantly, a complete series of live-attenuated dengue vaccine reduced 4G2 FLE bias, encouraged the recruitment of non-fusion-loop epitopes, and lessened FcγRIIa-biased antibody activity. Overall, these results show that vaccination platform, timing, and regimen are critical determinants of epitope dominance and antibody quality following flavivirus vaccination.

#2

Clinico-etiological profile and prognostic factors of acute febrile encephalopathy in children: a prospective study from Indian subcontinent.

Journal of tropical pediatrics2026 Feb 09

Acute febrile encephalopathy (AFE) is a common neurological emergency in all age groups. In tropical regions, long-standing infections such as Japanese encephalitis and bacterial meningitis continue to be major causes of AFE, while changing presentations of familiar infections and newly emerged diseases like COVID-19 are also becoming increasingly notable. To describe various clinical presentations, etiology and mortality of AFE in pediatric age group. This prospective observational study was undertaken in a tertiary care institute of Northern India from April 2022 to April 2023. Children aged 1 month to 18 years presenting to the pediatric emergency department with fever of <2 weeks duration and altered sensorium lasting >24 hours were eligible for inclusion. A total of 100 patients (49% males) with AFE were enrolled. The mean (SD) duration of encephalopathy was 1.39 (0.69) days. The most frequent etiologies were viral encephalitis (17%), dengue encephalopathy (12%), and hepatic encephalopathy (9%). The peak incidence occurred between August and November. The overall case fatality rate was 33%. Under-5 children with severe acute malnutrition (SAM) had the highest fatality rate (56%, 9/16). Among survivors, 16% (11/67) had poor functional outcomes. Higher odds of mortality were observed in patients with a Glasgow coma scale score <8, hypoglycemia at admission, requirement for mechanical ventilation or inotropic support, and presence of multiorgan dysfunction. AFE demonstrates a predictable seasonal pattern and is associated with high mortality and morbidity, particularly in under-5 children with SAM, who represent the most vulnerable group.

#3

A time-varying geospatial model of habitat suitability for Japanese encephalitis virus vectors and vertebrate hosts in Australia.

PLoS neglected tropical diseases2026 Mar 20

In the austral summer of 2021-2022, Australia experienced an unprecedented Japanese encephalitis virus (JEV) outbreak, with detections over 3000 km south of previous occurrences. Given the limited knowledge of JEV transmission ecology in Australia, we developed geospatial models of transmission risk to support the public health response. We created time-varying habitat suitability models for suspected mosquito vectors and ardeid hosts using month-scaled occurrence and covariate data from 2000-2023. Ardeid host presence-absence data were obtained from eBird and BirdLife Australia, with habitat suitability estimated using gradient-boosted regression tree models. A national dataset of Culex occurrences was compiled from mosquito surveillance records, literature, and biodiversity databases. Penalised logistic regression was used to model mosquito vector habitat suitability. Vector and host habitat predictions for the outbreak peak in February 2022 were rescaled using JEV infection locations in the public domain to create a combined habitat suitability surface. Our models aligned with detected JEV infections at the continental scale, highlighting transmission suitability across tropical northern Australia and major inland drainage basins in the East. Unlike existing models, we predicted lower suitability along the eastern seaboard, suggesting a delimiting effect of the Great Dividing Range. Our approach provides the most comprehensive and temporally dynamic models for JEV hosts and vectors in Australia, with a significantly larger vector dataset than previous studies. The novel method of rescaling host and vector outputs into a combined surface offers new insights into JEV transmission risk. Favourable conditions were repeated in 2023 with few detected infections, emphasising that JEV ecology in Australia remains poorly understood. This study's results can support improvements in arbovirus surveillance systems, promoting earlier detection of circulating viruses. Increased focus on vector ecology and distributions is crucial for better understanding JEV transmission in Australia.

#4

Isolation and characterization of Japanese encephalitis virus genotype I from pig provides evidence for the presence of the virus in nasal secretion and co-circulation of JEV genotypes in Assam, India.

Frontiers in cellular and infection microbiology2026

Japanese encephalitis (JE) is a leading cause of viral encephalitis, among children, in many Asian countries despite the availability of effective vaccines. There are five JE virus genotypes (GI through GV), with GIII being the most prevalent. However, in the past three decades GI has emerged as the dominant genotype across several Asian countries, while the reappearance of GV is a concern due to the reduced cross-neutralization offered by existing GIII-based vaccines. Although both GI and GIII have been reported to co-circulate in India, all previous JEV isolations from pigs have been of the GIII. The objective of the study was to elucidate the JEV genotype diversity among pigs in Assam through molecular and virological investigation. We collected blood, serum and nasal swab samples from apparently healthy pigs as a part of routine disease surveillance in pigs of Kamrup (Rural) district, Assam, India. The samples were processed using standard molecular biology (qRT-PCR, Gene Sequencing, Phylogenetic analysis) and virological techniques (Virus isolation, immunofluorescence, plaque assay) for JE virus detection, isolation and characterization. In this study, we report the first isolation and characterization of a JEV GI from a nasal swab of a naturally infected pig from Assam, India and the isolate was designated as JEV/Pig/Assam/NIVEDI-1/2025 (GI). The identity of the JEV isolate was confirmed by RT-qPCR, phylogeny based on 5'UTR-prM region, full-length envelope protein gene, and immunofluorescence assay. The isolate reached a peak titer of 106.5 TCID50/mL at 72 h post-infection in Porcine stable kidney cells and produced smaller plaques (1.88 ± 0.56 mm) than the reference GIII strain (2.68 ± 0.48 mm) (p < 0.01). The findings underscore that JEV GI is circulating in Assam and there is need for strengthened JEV surveillance in swine to monitor genotype shifts, understand viral evolution, and generate field isolates critical for vaccine evaluation and preparedness against emerging JEV genotypes. The study also demonstrates the feasibility of using nasal swabs for virus detection and isolation thereby providing evidence for the presence of JEV in nasal secretion of naturally infected pigs.

#5

Spatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model.

Nature communications2026 Mar 17

The cellular interactions that drive the neuropathology of most neuroinvasive viruses remain elusive. We used Japanese encephalitis virus (JEV) to infect female BALB/c mice and applied Stereo-seq to simultaneously capture host and viral transcriptomes in situ, thereby constructing a comprehensive spatiotemporal atlas of Japanese encephalitis (JE) pathogenesis. Our analysis pinpoints Ly6c2+ monocytes as the primary virus carrier, the most abundant infiltrating immune cell type, and a major source of IFN-γ in the infected mouse brain. Following infection, Ackr1+ endothelial cell activation is linked to blood-brain barrier disruption and immune cell chemotaxis, particularly Ly6c2+ monocytes. The crosstalk between these two cell types appears to orchestrate the pronounced inflammation and cell death, including pyroptosis and necroptosis, which radiate from the vasculature to different brain regions. Disrupting the activation and interactions of these two cell types may help mitigate JE progression. This study also provides a technical framework for investigating the pathogenesis of other neurotropic viruses.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC4.308 artigos no totalmostrando 200

2026

Knockdown resistance (kdr) mutations in the Japanese encephalitis virus vector Culex tritaeniorhynchus from the Republic of Korea.

Tropical medicine and health
2026

Umbelliferone Inhibits Zika Virus (ZIKV) NS5 Activity and Replication In Vitro.

ACS omega
2026

Inactivated Japanese encephalitis virus vaccination imprints fusion loop-biased antibody responses that are attenuated by repeated live-attenuated dengue vaccination.

medRxiv : the preprint server for health sciences
2026

Clinico-etiological profile and prognostic factors of acute febrile encephalopathy in children: a prospective study from Indian subcontinent.

Journal of tropical pediatrics
2026

Progress and Innovation in Japanese Encephalitis Vaccines: Toward Global Immunization.

Recent advances in anti-infective drug discovery
2026

A time-varying geospatial model of habitat suitability for Japanese encephalitis virus vectors and vertebrate hosts in Australia.

PLoS neglected tropical diseases
2026

Isolation and characterization of Japanese encephalitis virus genotype I from pig provides evidence for the presence of the virus in nasal secretion and co-circulation of JEV genotypes in Assam, India.

Frontiers in cellular and infection microbiology
2026

Spatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model.

Nature communications
2026

Biochemical, molecular, and in silico insights into the effects of cyphenothrin on Culex quinquefasciatus mosquitoes.

Parasites &amp; vectors
2026

Modelling Aedes albopictus management, incorporating immigration and bi-directional Wolbachia interactions.

Journal of pest science
2026

Adult Japanese encephalitis in a non-endemic area: A case highlighting diagnostic limitations of targeted next-generation sequencing.

Diagnostic microbiology and infectious disease
2026

Japanese encephalitis virus envelope protein activates the TLR4/NF‑κB pathway to induce testicular inflammation.

Veterinary microbiology
2026

Biosensors for the detection of arthropod-borne veterinary viruses: A comprehensive review.

Veterinary and animal science
2026

Molecular evidence of Japanese encephalitis virus in poultry: Need to further elucidate JEV epidemiology.

Comparative immunology, microbiology and infectious diseases
2026

Interplay between flaviviruses and the interferon response: mechanisms of immune evasion and therapeutic implications.

Frontiers in pharmacology
2026

In silico Exploration of Aegle Marmelos-Derived Compounds as Potential Inhibitors of NS5 RdRp in Japanese Encephalitis Virus.

Combinatorial chemistry &amp; high throughput screening
2026

Japanese Encephalitis: Understanding Its Impact, Prevention, and the Role of Vaccination.

Reviews in medical virology
2026

1'- and 4'-Cyano Modified Adenosine Analogs Against Prototypic Flavivirus RNA-Dependent RNA Polymerases.

Viruses
2026

mRNA Vaccine Against Japanese Encephalitis Virus Genotype IV Protects Against Lethal Infection.

Viruses
2026

A Bovine Cell Line Resistant to Japanese Encephalitis Virus Entry but Permissive to Post-Entry Replication.

Viruses
2026

Cocrystals of telmisartan with ascorbic acid: Enhanced solubility and antiviral potency against Japanese encephalitis virus.

Journal of pharmaceutical sciences
2026

Timeliness of Routine Vaccination, Catch-Up Completion, and Immune Function in Chinese Children with Special Healthcare Needs: A Retrospective Cohort Study.

Vaccines
2026

Transcriptomic insights into the neuropathogenic and immune response alterations in mouse neurons challenged with west nile and japanese encephalitis viruses.

Virology journal
2026

NS4B and NS5 mutations expand the temperature range permissive for the replication of dual-host affiliated insect-specific flaviviruses in mosquito cells.

Archives of virology
2026

Cytokine-based rapid process control of live virus production: MCP-1 as a cross-family biomarker in Vero cells.

Journal of virological methods
2026

Trend of zoonotic diseases outbreaks in India: a secondary data analysis of Integrated Disease Surveillance Programme data, 2010-2023.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2026

Hydranencephaly and porencephaly predominated among neuropathologic findings in stillborn and neonatal piglets during the first major outbreak of Japanese encephalitis in Australia.

Veterinary pathology
2026

Neuroinflammation and blood-brain barrier disruption in Japanese encephalitis virus infection: mechanisms, therapeutic targets, and intervention strategies.

Archives of pharmacal research
2026

Genotype-resolved NS5 stability predicts Japanese encephalitis virus fitness.

Virus genes
2026

Humoral and cellular responses to a tetravalent dengue vaccine (TAK-003) in adults from a dengue non-endemic region: An open-label phase 2 trial.

Vaccine
2026

Japanese Encephalitis crisis in Assam, India: call for targeted action as cases surge statewide.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2025

An integrated surveillance in Zhejiang Province: ecological and pathogen survey of vectors and reservoir hosts in 2024.

Frontiers in veterinary science
2026

NAD+ Homeostasis Attenuates Japanese Encephalitis Virus Infection Progression.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2026

Association of parental vaccination readiness and descriptive norms with childhood vaccination status.

Vaccine
2026

Porcine USP18 inhibits Japanese encephalitis virus replication by regulating the type I interferon signaling pathway.

Veterinary microbiology
2026

Bacterial community structure and diversity of common mosquito species in Chengdu: Insights from PacBio third-generation sequencing and public health implications.

PLoS neglected tropical diseases
2026

Phytol from Sphaeranthus indicus: A Natural Insecticide Against Aedes aegypti and Culex quinquefasciatus.

Acta parasitologica
2026

Serological evidence of West Nile virus circulation in Indonesia: Initial insights into an underrecognized flavivirus threat.

PloS one
2026

Changing trends of vector-borne diseases after the COVID-19 pandemic in India.

Journal of infection in developing countries
2025

Review of selected mosquito-borne diseases: arboviruses (dengue, chikungunya, Zika, West Nile, Japanese encephalitis, yellow fever) and parasitic diseases (malaria, lymphatic Filariasis).

Frontiers in public health
2025

Prioritizing climate-sensitive zoonotic diseases in Bangladesh: integrating climate hazards, pathogen transmissibility and potential health outcomes.

The journal of climate change and health
2025

Neutrophil depletion at the early stage of Japanese encephalitis virus infection affects CD8+ T cell infiltration into the mouse brain and causes severe encephalitis.

Frontiers in immunology
2026

Mosquito-capsid interactions contribute to flavivirus vector specificity.

Nature
2026

Downmodulation of cholesterol biosynthetic network governs activation of the innate immune response to Japanese encephalitis virus infection.

Journal of virology
2025

The application of DNA markers in population genetics of mosquitoes: a comprehensive review.

Frontiers in insect science
2026

Analysis of Vector Mosquito Control Status Using Insecticide Purchase Data from Public Health Institutions in the Republic of Korea (2019-2023).

Jugan geon-gang gwa jilbyeong
2026

Newcastle disease virus hijacks mitophagy to reprogram amino acid metabolism for enhanced replication.

Autophagy
2026

From association to action: Advancing microbiome evidence toward decision-grade insights in Japanese encephalitis virus research.

Veterinary microbiology
2026

Promoter-like activity on the minus strand supports sfRNA biogenesis in Japanese encephalitis virus.

Virology
2025

Construction and Evaluation of a Chimeric Japanese Encephalitis Virus Vaccine Candidate Strain with Chaoyang Virus as the Backbone.

Vaccines
2026

The Emerging JEV Genotype 5 Exhibits Distinct Codon Usage Characteristics.

Pathogens (Basel, Switzerland)
2026

Opportunities and Challenges of mRNA and VLP Technologies for Pan-Flavivirus Vaccine Development: Focus on Conserved Quaternary Epitope Conformations.

International journal of molecular sciences
2026

Application of Orthoflavivirus Pseudovirus Technology in Antiviral Research.

International journal of molecular sciences
2026

Australian Paediatric Surveillance Unit (APSU) Annual Surveillance Report 2024.

Communicable diseases intelligence (2018)
2026

NUP98 regulates orthoflavivirus replication through interaction with vRNA and can be targeted for antiviral purposes.

Nucleic acids research
2026

Preclinical evaluation of DENV1 mRNA vaccines in mice: Toward improved neutralizing antibody and T cell responses.

Biomedicine &amp; pharmacotherapy = Biomedecine &amp; pharmacotherapie
2026

Mitochondrial genome analysis and molecular identification of two Culex tritaeniorhynchus (Diptera: Culicidae) clades from the Republic of Korea.

Journal of medical entomology
2026

Antiviral Drug Discovery from Typha angustifolia Pollen: Computational Analysis Targeting Flaviviridae Polymerases and Entry Proteins.

Current pharmaceutical design
2026

Japanese encephalitis virus activates the NLRP3/caspase-1/GSDMD signaling pathway in dopaminergic neurons.

PLoS neglected tropical diseases
2026

Distinguishing Leptospirosis from Other Causes of Acute Encephalitis Syndrome: Clinical Insights.

Annals of African medicine
2026

A community-based focal serosurvey for West Nile virus infection following a surge in cases in 2024 in Kerala, India: a cross-sectional analysis.

New microbes and new infections
2026

Vaccine delay in routine childhood vaccines in the post-COVID-19 era in Jiangning, Nanjing, China.

Preventive medicine reports
2026

Evaluation of protective efficacy of an inactivated Japanese encephalitis virus genotype Ⅴ strain in mice.

NPJ vaccines
2026

Secretory NS1' protein of orthoflavivirus promotes viral transmission to mosquitoes by suppressing the RNAi pathway.

Science China. Life sciences
2026

Japanese Encephalitis: a case of remarkable recovery after 68 days of ICU admission in a 30 -years-old-male.

BMC infectious diseases
2026

Identification and characterization of two novel linear B cell epitopes on the envelope protein of Japanese encephalitis virus.

International journal of biological macromolecules
2026

Implications of immune responses to DENV, JEV, and ZIKV Infections for cross-reactivity and considerations for vaccine evaluation.

Virus research
2026

Virtual screening, molecular dynamics simulations, and antiviral evaluation of Ocimum basilicum phytoconstituents against Japanese encephalitis virus.

Archives of virology
2026

A rare cause of shock in cases of refractory hypotension, hypoproteinaemia and haemoconcentration.

Clinical medicine (London, England)
2026

Projecting long-term excess risks of major infectious diseases associated with future extreme weather events in Thailand.

PLoS neglected tropical diseases
2026

Zinc finger protein ZNF33B facilitates Japanese encephalitis virus replication by regulating m6A modification on Ifih1 and Irf3 transcripts to antagonize antiviral response.

Cell &amp; bioscience
2025

Detection of dengue virus encephalitis in central part of Sri Lanka.

World journal of virology
2025

Flavivirus NS1-triggered endothelial dysfunction promotes virus dissemination.

PLoS pathogens
2025

Characterizing Epidemiological Trends and Associated Factors of Japanese Encephalitis in China: Insights From a 17-Year National Surveillance Analysis.

Transboundary and emerging diseases
2025

Prevalence of Antibodies to Japanese Encephalitis Virus and Severe Fever with Thrombocytopenia Syndrome Virus in Wild Boars Captured Across Different Locations in Toyama Prefecture, Japan.

Viruses
2025

Development and Application of a Rapid Field Detection Technology for DENV-2 Based on the HUDSON Nucleic Acid Extraction-Free/RT-RAA/CRISPR-Cas12a System.

Viruses
2025

Generation of a Human-Mouse Chimeric Anti-Japanese Encephalitis Virus and Zika Virus Monoclonal Antibody Using CDR Grafting.

Microorganisms
2025

Non-Dominant Genotypes (GII, GIV and GV) of Japanese Encephalitis Virus Exhibit an Elevated Evolutionary Rate in Nature.

Microorganisms
2025

Complete Genome Sequences of Human Japanese Encephalitis Virus Genotype V Isolates in Korea Reveal Genotype-Specific Amino Acid Signatures.

Pathogens (Basel, Switzerland)
2025

Advances and Challenges in Vaccination and Therapeutic Strategies Against Japanese Encephalitis Virus.

Pathogens (Basel, Switzerland)
2025

CC-90009, a Cereblon E3 Ligase Modulator, Exhibits Antiviral Efficacy Against JEV In Vitro and In Vivo via Targeted Degradation of GSPT1 and Viral NS5 Protein.

Pharmaceutics
2025

Japanese Encephalitis With Central Nervous System Tuberculosis With Quadriplegia: A Rare Conundrum in Resource Limited Setting.

Sage open pediatrics
2026

Engineered dengue virus NS1 mRNA-lipid nanoparticle induces therapeutic IgG production that lacks autoantibody activity and neutralizes NS1 entry in liver cells.

Vaccine
2025

Optimizing Humoral Immunity for Durable and Broad Protection in Flavivirus Vaccines.

Vaccines
2025

Transforming One Health in India: National Multisectoral Mixed Method Study on Prioritization of Zoonotic Diseases.

JMIR public health and surveillance
2025

Computational analysis of Non-synonymous SNP effects on human PLVAP gene structure and function.

Journal of applied genetics
2025

Molecular detection of Japanese encephalitis virus and Murray Valley encephalitis virus in mosquitoes: implications for disease transmission in the Northern Territory, Australia.

Journal of vector ecology : journal of the Society for Vector Ecology
2025

Universal and quantitative detection of double-stranded RNAs as a signature of pan-virus infections using a luciferase-based biosensor.

Journal of biological engineering
2025

Surveillance of adverse events following immunisation in Australia annual report, 2022.

Communicable diseases intelligence (2018)
2025

Endophilin mediated endocytosis and epidermal growth factor receptor govern Japanese encephalitis virus entry and infection in neuronal cells.

PLoS pathogens
2026

The global threat of vaccine-preventable neurological diseases.

Nature reviews. Neurology
2025

Thioester-Containing Protein TEP27 in Culex quinquefasciatus Promotes JEV Infection by Modulating Host Immune Function.

International journal of molecular sciences
2025

Acute encephalitis syndrome and Japanese encephalitis in India: insights from a nationally representative laboratory surveillance network, 2014-2023.

BMC infectious diseases
2025

Climate Change and Epidemic Preparedness: High-Risk Regions of Japanese Encephalitis Virus in Victoria, Australia, From 2021 to 2100.

Health security
2026

Arbovirus-Host Epigenetic Interplay: Unraveling the Neurological Mechanisms and Therapeutic Opportunities.

Reviews in medical virology
2025

Evaluation of vector competence of Culex tritaeniorhynchus and Culex pipiens pallens for Japanese encephalitis virus genotype III and V.

Parasites &amp; vectors
2025

Flaviviridae RdRp exploits NSUN2-driven m5C methylation to establish persistent infection.

PLoS pathogens
2025

Targeting envelope lipids with 2,6‑di‑O‑methyl‑3‑acetyl‑β‑cyclodextrin impairs infectivity of SARS‑CoV‑2 and Japanese encephalitis virus.

Journal of virology
2026

Rethinking WHO's Japanese encephalitis vaccination policies: why age limits no longer match outbreak reality.

Journal of travel medicine
2025

[Mosquito Surveillance at Airports and Seaports to Prevent and Control Emerging Mosquito-borne Diseases in the Republic of Korea, 2024].

Jugan geon-gang gwa jilbyeong
2025

[Mosquito Surveillance at Airports and Seaports to Prevent and Control Emerging Mosquito-borne Diseases in Korea, 2023].

Jugan geon-gang gwa jilbyeong
2025

[Surveillance of Japanese Encephalitis Vector Mosquitoes in the Republic of Korea in 2024].

Jugan geon-gang gwa jilbyeong
2025

[Identification of Culex quinquefasciatus Highlights the Need for Strengthened Vector Mosquito Surveillance in the Republic of Korea].

Jugan geon-gang gwa jilbyeong
2025

Flavivirus Nonstructural Protein 1‑Driven Coagulation via Tissue Factor-Bearing Microvesicles: A Pilot Study.

ACS omega
2026

Seasonal Trends of Major Respiratory, Gastrointestinal, and Other Viral Infections in Korea: An Analysis Before, During, and After the Coronavirus Disease 2019 Pandemic.

Annals of laboratory medicine
2025

Epidemiological and antigenic inferences from serological cross-reactivity among arboviruses.

Science translational medicine
2025

Pathogen profiles in CSF from patients with acute infectious meningitis or encephalitis: a multicenter study based on multiplex PCR and mNGS in China, 2018-2019.

BMC infectious diseases
2025

Safety profile of Japanese encephalitis vaccines: a comprehensive analysis of vaccine adverse event reports from 1993 to 2025.

Frontiers in public health
2025

Deciphering core genetic and pathway signatures of Japanese encephalitis virus using transcriptomics.

Virusdisease
2025

Mutation in the knockdown resistance gene and population genetic structure in Culex tritaeniorhynchus from Guizhou Province.

Parasites &amp; vectors
2025

National burden of and optimal vaccine policy for Japanese encephalitis virus in Bangladesh: a seroprevalence and modelling study.

The Lancet. Infectious diseases
2025

Plant-Derived Carotenoid Lutein Demonstrates Multifunctional Antiviral Activity against Influenza A Virus in vitro.

Journal of microbiology and biotechnology
2026

Serological cross-reactivity and identification of an acute Seoul orthohantavirus case in a dengue outbreak from Vietnam.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2025

Zoonotic Disease Transmission May Be Linked to Host Co-Occurrence Network Topology.

Annals of the New York Academy of Sciences
2025

Ecological suitability of Japanese encephalitis virus in Australia: A modelling analysis of vector-host transmission dynamics to potential spillover in humans.

PLoS neglected tropical diseases
2025

Anti-NMDA receptor encephalitis following Murray Valley encephalitis: a case report.

ASM case reports
2025

Report of two severe cases of Japanese encephalitis virus in travelers returning to France, 2023-2024: clinical, diagnostic, and public health implications.

ASM case reports
2026

Japanese encephalitis virus promotes its replication in neuronal cells by enhancing glycolysis via hypoxia-inducible factor-1α.

Virology
2025

VEGFR-3 deficiency in astrocytes exacerbates Japanese encephalitis virus-induced neuroinflammation in mouse brains.

Zoological research
2025

Reliable estimates of Japanese encephalitis virus evolutionary rate supported by a formal test of temporal signal.

Molecular genetics and genomics : MGG
2025

Flavivirus-based bivalent nanoparticle vaccines induce neutralizing antibodies and Th1 responses against flavivirus and coupling antigens.

iScience
2026

Coming of age: mRNA vaccines for orthoflaviviruses.

Trends in immunology
2025

Virucidal activity of Cannabis sativa L. (hemp) root and stem extracts against Japanese encephalitis virus: role of stigmasterol.

Archives of virology
2025

Japanese encephalitis virus infection modulates gut microbiota of immunocompetent mice.

Veterinary microbiology
2025

The gut microbiota limits systemic inflammation during neurotrophic viral CNS infection by priming tonic type I interferon signaling.

Journal of neuroinflammation
2025

Signaling pathway of DNA replication and toll-like receptors was inhibited in C6/36 cells infected with Japanese encephalitis virus.

Virology journal
2025

The hidden threats posed by Japanese encephalitis virus genotype V.

Journal of virology
2025

Molecular and Serological Surveillance of Mosquito-Borne Viruses in Racehorses or Mosquitoes From Horse Farms in Shanghai, China, 2022.

Transboundary and emerging diseases
2025

MRNA innovation: preparing for arboviruses and the next global outbreak.

Annals of medicine and surgery (2012)
2025

Corrigendum to "Japanese encephalitis virus NS3 captures the protein translation element by interacting with HNRNPH1 to promote viral replication" [Int. J. Biol. Macromol. Volume 289, February 2025, 138826; https://doi.org/10.1016/j.ijbiomac.2024.138826].

International journal of biological macromolecules
2025

Movement Disorders in West Nile Virus Infection: A Systematic Review of Reported Cases and Conference Abstracts.

Movement disorders clinical practice
2025

Immunogenicity, immune persistence, and safety of japanese encephalitis vaccine schedules among adults in Ningxia, China.

NPJ vaccines
2026

Validation of prototype virus inactivation from seven virus families of pandemic potential with a novel low-cost, field-deployable RNA extraction and storage method.

Journal of virological methods
2025

Genotype-Specific Vector Competence of Aedes albopictus for Japanese Encephalitis Virus Genotypes I, III, and V.

Viruses
2025

An integrative approach to DNA barcoding, geometric morphometrics, and machine learning for field identification of Culex mosquitoes (Diptera: Culicidae), with implications for vector-borne disease surveillance.

Acta tropica
2025

Analysis and spatiotemporal distribution of infectious disease early warning signals during a major flooding event: New South Wales and Queensland 2022 floods.

Public health
2025

Japanese Encephalitis Vaccine in Low- and Middle-Income Countries (LMICs): A Narrative Review of Efficacy, Effectiveness, Safety, Cost, and Policy.

Vaccines
2025

Spectrum of movement disorders in Japanese encephalitis: a systematic review of case reports, case series, and cohort studies.

Acta neurologica Belgica
2026

RNAi therapeutics targeting Japanese encephalitis virus: Gene targets, delivery platforms, and translational barriers.

Virology
2025

Serum-Free Japanese Encephalitis Virus Production in a Single-Use Fixed-Bed Bioreactor.

Engineering in life sciences
2025

Spatial gene expression analysis reveals pathological niches in Japanese encephalitis virus neuroinvasion.

Proceedings of the National Academy of Sciences of the United States of America
2025

Unveiling immunity dynamics: Serological characteristics of antibodies against Japanese encephalitis virus in Guangdong, China.

PLoS neglected tropical diseases
2025

Diversity of mosquitoes (Diptera: Culicidae) in Meghalaya State, India, with notes on seven new country records.

Zootaxa
2026

Antiviral and neuroprotective activity of diallyl disulfide in Japanese encephalitis virus-challenged SH-SY5Y cells: a post-treatment approach for greater specificity.

Naunyn-Schmiedeberg's archives of pharmacology
2025

Skin related manifestations of Japanese encephalitis-Observations from an outbreak in Assam (India).

Indian journal of dermatology, venereology and leprology
2026

Integrated diagnostic approach for mixed Plasmodium infection among acute febrile patients: rare incidence from Eastern Uttar Pradesh.

Diagnostic microbiology and infectious disease
2025

Low frequency of N-methyl-D-aspartate receptor autoimmunity in tick-borne encephalitis.

PloS one
2026

From vaccination success to new outbreaks: reassessing Japanese encephalitis control in Nepal.

The Lancet. Microbe
2025

SMART-RNA-Metavirome: a practical RNA metavirome platform compatible with high-throughput sequencing of both short and long reads.

Infectious diseases of poverty
2025

Tracing the evolutionary trajectory of Japanese encephalitis virus across hosts and countries.

Scientific reports
2025

Development and application of a CRISPR/Cas12a-based reverse transcription-recombinase polymerase amplification assay with lateral flow dipstick and fluorescence detection for Getah virus.

PeerJ
2025

Socioeconomic drivers of encephalitis burden in the post-COVID era: a 204-country analysis from global burden of disease study 2021.

Frontiers in public health
2026

Comparative analysis of RT-qPCR assay sensitivity and process limit of detection for Japanese encephalitis virus (JEV) detection in piggery wastewater.

Journal of virological methods
2025

Ready for takeoff? exploring United States health care providers' pretravel consultation priorities, gaps, barriers, and opportunities.

Travel medicine and infectious disease
2025

PRKAG1 mediates the anti-Japanese encephalitis virus effect of Nitazoxanide through autophagy.

Veterinary microbiology
2025

Viral Infection and the Blood-Brain Barrier: Molecular Research Insights and Therapies.

The Journal of infectious diseases
2025

A nitrogen-containing diphyllin derivative C156-P1 exhibited broad-spectrum antiviral activity against Flaviviridae viruses by preventing endosomal acidification.

Antimicrobial agents and chemotherapy
2025

Severe Japanese encephalitis of a pregnant woman in the first trimester of pregnancy: a case report.

BMC infectious diseases
2025

A novel Gaussia luciferase immunoprecipitation assay for the detection of Getah virus antibodies in pigs.

Veterinary journal (London, England : 1997)
2025

The Dual Role of Autophagy in the Pathogenesis of Arboviruses With a Focus on JEV and DENV.

Reviews in medical virology
2025

Antibody responses to Japanese encephalitis virus and dengue virus serotype 2 in children from an orthoflavivirus endemic region after IMOJEV vaccination.

PLoS neglected tropical diseases
2025

Pyruvate kinase M2 modulates Japanese encephalitis virus replication in neuronal cells.

The Journal of general virology
2026

Active constituent nonacosane from Sphaeranthus indicus (Asterales: Asteraceae) leaves as a potent larvicidal agent against Aedes aegypti (Diptera: Culicidae) and Culex quinquefasciatus (Diptera: Culicidae).

Parasitology international
2025

Japanese Encephalitis Virus Genotype 5 Infectious Clone and Reporter System for Antiviral Evaluation.

Journal of medical virology
2025

Unleashing the Antiviral Potential of Stapled Peptides: A New Frontier in Combating Human Neurotropic Viral Infections.

Microbial biotechnology
2025

[Analysis of the immunization status and related factors for children aged 0-7 years old with special health status in Tianhe District, Guangzhou City from 2023 to 2024].

Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]
2025

Insect-specific viruses: transmission dynamics and biological control strategies against arboviruses.

Frontiers in microbiology
2025

Impact of peri-urban pig farms on mosquito community structure in Yogyakarta, Indonesia.

Current research in parasitology &amp; vector-borne diseases
2025

Trace amounts of cobalt serve as an adjuvant for unglycosylated JEV-ED3 expressed in E. coli, inducing a potent virus-neutralizing immune response.

Vaccine
2025

Myosin heavy chain 9 is a critical host factor for Japanese encephalitis virus entry and replication in U251 cells.

Veterinary microbiology
2025

Rutin Attenuates Virus Entry and Replication and Exerts Neuroprotection in Experimental Models of Japanese Encephalitis.

Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
2025

Enhancing Japanese Encephalitis diagnosis with differential ELISA testing in India: A comparative evaluation of two JE IgM capture ELISA kits.

Journal of vector borne diseases
2025

Transcriptomic response of mosquitoes to Japanese encephalitis virus and identification of its potential entry factors.

Npj viruses
2025

ZNF33B facilitates Japanese encephalitis virus replication by controlling HSPB1/8-mediated SUMOylation of nonstructural protein 5.

Journal of virology
2025

Potential high arbovirus exposure in INDOPACOM during U.S. service member deployment or exercises in Papua New Guinea.

MSMR
2025

Comprehensive insights into Japanese encephalitis virus: From molecular characterization to advanced detection and vaccine strategies.

Antiviral research
2025

Epidemiological characteristics and transmission dynamics of epidemic Japanese encephalitis in China: A modeling study.

The Journal of infection
2025

Dengue disease severity in humans is augmented by waning Japanese encephalitis virus immunity.

Science translational medicine
2025

Isolation and Identification of Arboviruses from Mosquitoes in Yuxi Region of Yunnan, China.

Vector borne and zoonotic diseases (Larchmont, N.Y.)
2025

Uncommon cells in cerebrospinal fluid in Japanese encephalitis: A case report.

Medicine
2025

Transferrin receptor 1 is an entry factor for Japanese encephalitis virus.

Veterinary microbiology
2025

Reverse transcription recombinase polymerase amplification-lateral flow assay for detection of pathogenic orthoflaviviruses in mosquito vectors.

PeerJ
2025

A Japanese encephalitis virus biological clone with an E gene point mutation exhibits in vitro and in vivo attenuation of neurovirulence.

The Journal of general virology
2025

Selective TLR ligand stimulation enhances in vivo mosquito-borne flavivirus pathogenicity.

Cell reports
2025

Programmable self-replicating JEV nanotherapeutics redefine RNA delivery in ALS.

Communications biology
2026

Pathogenic breaches: how viruses compromise blood-tissue barriers.

Tissue barriers
2025

Managing Japanese Encephalitis Virus as a Veterinary Infectious Disease Through Animal Surveillance and One Health Control Strategies.

Life (Basel, Switzerland)
2025

Electrochemical dengue sensor based on NS1 epitope-imprinted polymers.

Biosensors &amp; bioelectronics
2025

Machine-learning-based artificial intelligence tools for the diagnosis of tropical fevers: a systematic review and meta-analysis protocol of diagnostic test accuracy.

BMJ open
2025

Peripheral nerve injury mediated by JEV strain NX1889 infection and impairment of Schwann cells.

PLoS neglected tropical diseases
2025

Characteristics of Japanese encephalitis virus infection in NCG-hSTAT2+/+ mice: a novel model for studying neurological symptoms and immune response.

Disease models &amp; mechanisms
2025

Dominance of DENV-1 and Flavivirus Serological Cross-Reactivity During the 2016 Dengue Outbreak in Vietnam.

Journal of medical virology
2025

Surveillance of Japanese encephalitis virus in piggery effluent and environmental samples: a complementary tool for outbreak detection.

Applied and environmental microbiology
2025

Interaction of West Nile virus NS5 with orthoflavivirus SLA RNAs and their effects on viral replication and inhibition.

Journal of virology
2025

Pharmacological inhibition of the RhoA pathway by melatonin reduces viral replication and proinflammatory response against ZIKV and DENV-4 neuroinfections.

Frontiers in immunology
2025

Human T Cell Responses to Flavivirus Vaccines.

European journal of immunology
2025

Japanese Encephalitis in pig populations of Cachar district of Southern Assam: Emphasizing the need for enhanced surveillance.

Journal of vector borne diseases
2025

25-Hydroxy cholesterol effectively inhibits Japanese encephalitis virus infection in a cellular model.

Biochemical and biophysical research communications
2025

Telmisartan, an anti-hypertensive drug, impedes JEV infection, possibly via the AT1/PPARγ axis.

Microbiology spectrum
2025

Vector competence of European Aedes mosquito species for Japanese encephalitis virus under fluctuating temperature conditions.

Current research in parasitology &amp; vector-borne diseases
Ver todos os 4.308 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Inactivated Japanese encephalitis virus vaccination imprints fusion loop-biased antibody responses that are attenuated by repeated live-attenuated dengue vaccination.
    medRxiv : the preprint server for health sciences· 2026· PMID 41867205mais citado
  2. Clinico-etiological profile and prognostic factors of acute febrile encephalopathy in children: a prospective study from Indian subcontinent.
    Journal of tropical pediatrics· 2026· PMID 41866134mais citado
  3. A time-varying geospatial model of habitat suitability for Japanese encephalitis virus vectors and vertebrate hosts in Australia.
    PLoS neglected tropical diseases· 2026· PMID 41860997mais citado
  4. Isolation and characterization of Japanese encephalitis virus genotype I from pig provides evidence for the presence of the virus in nasal secretion and co-circulation of JEV genotypes in Assam, India.
    Frontiers in cellular and infection microbiology· 2026· PMID 41852661mais citado
  5. Spatial transcriptomics uncovers vasculature-centered cellular interactions driving Japanese encephalitis progression in a mouse model.
    Nature communications· 2026· PMID 41844605mais citado
  6. One health perspectives on the epidemiological features and changing incidence of natural focus and vector-borne infectious diseases in China: An observational trend study.
    One Health· 2026· PMID 41993771recente
  7. Human antibodies against West Nile and related orthoflaviviruses.
    bioRxiv· 2026· PMID 41993435recente
  8. [Analysis on the epidemiological characteristics and prognosis of sequelae of Japanese encephalitis in Zhejiang Province from 2017 to 2024].
    Zhonghua Yu Fang Yi Xue Za Zhi· 2026· PMID 41991283recente
  9. Susceptibility of wild and domestic songbirds to Usutu virus.
    PLoS Negl Trop Dis· 2026· PMID 41990089recente
  10. Investigating antibody cross-reactivity and transmission dynamics of alphaviruses and flaviviruses using a multiplex serological assay.
    Nat Commun· 2026· PMID 41986360recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:79139(Orphanet)
  2. MONDO:0019209(MONDO)
  3. GARD:6797(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q738292(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Encefalite japonesa
Compêndio · Raras BR

Encefalite japonesa

ORPHA:79139 · MONDO:0019209
Prevalência
Unknown
Herança
Not applicable
CID-10
A83.0 · Encefalite japonesa
CID-11
Ensaios
5 ativos
Início
All ages
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0014057
EuropePMC
Wikidata
Wikipedia
Papers 10a
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