É uma inflamação grave e repentina do cérebro, conhecida como encefalite aguda, causada por uma reação autoimune. Isso acontece quando os anticorpos do próprio corpo atacam uma parte específica do cérebro chamada receptor NMDA de glutamato. Geralmente afeta mulheres e, na maioria dos casos, está associada à presença de um tumor, sendo o mais comum um teratoma no ovário. Quando há um tumor nesses pacientes, a encefalite é considerada uma "síndrome paraneoplásica". Isso significa que o problema no cérebro é uma reação do sistema imunológico ao tumor que está em outra parte do corpo. Os sintomas incluem alterações psiquiátricas (como confusão, agitação, delírios) e crises epilépticas (convulsões). É uma condição que pode ser fatal. No entanto, geralmente é reversível se o tumor for removido rapidamente.
Introdução
O que você precisa saber de cara
É uma inflamação grave e repentina do cérebro, conhecida como encefalite aguda, causada por uma reação autoimune. Isso acontece quando os anticorpos do próprio corpo atacam uma parte específica do cérebro chamada receptor NMDA de glutamato. Geralmente afeta mulheres e, na maioria dos casos, está associada à presença de um tumor, sendo o mais comum um teratoma no ovário. Quando há um tumor nesses pacientes, a encefalite é considerada uma "síndrome paraneoplásica". Isso significa que o problema no cérebro é uma reação do sistema imunológico ao tumor que está em outra parte do corpo. Os sintomas incluem alterações psiquiátricas (como confusão, agitação, delírios) e crises epilépticas (convulsões). É uma condição que pode ser fatal. No entanto, geralmente é reversível se o tumor for removido rapidamente.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 34 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 53 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Encefalite receptor NMDA
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 782
Complications, outcomes, and implications of a prolonged vegetative state in anti-NMDA receptor encephalitis: a retrospective international cohort study.
In anti-NMDA receptor (NMDAR) encephalitis, delayed recovery and slow improvement makes it difficult to assess treatment refractoriness, leaving a knowledge gap about prolonged impaired consciousness. We aimed to assess treatment response, long-term outcomes, and their predictors in patients with NMDAR encephalitis and a prolonged vegetative state. In this international retrospective cohort study, we included patients with NMDAR encephalitis from Jan 1, 2007 to Sept 30, 2024 who remained in a vegetative state (unresponsive wakefulness) for 9 months or longer in 21 hospitals across Austria, Brazil, Chile, China, Germany, Hong Kong, Japan, the Netherlands, Spain, Switzerland, and the USA. Data on disease presentation and long-term outcomes were collected via medical record review and a structured questionnaire sent to referring physicians. Outcomes were death, ability to follow commands, reaching a modified Rankin Scale (mRS) score of 2, or complete recovery (mRS 0 with return to premorbid activities). Competing risks analysis was used to assess survival and predictors of death, mRS score 2, and recovery. 45 patients were identified (38 female and seven male; median age 22 [IQR 19-31] years). The patients had impaired consciousness a median of 9 days after symptom onset (IQR 5-16). All 45 patients received first-line immunotherapy; 41 (91%) received second-line, and 18 (40%) received third-line immunotherapies. 21 (47%) of 45 patients had ovarian teratomas, which were removed in 20 patients. Median durations were: vegetative state 399 days (IQR 307-698); intensive care unit stay 275 days (189-354); mechanical ventilation 270 days (195-394); and hospitalisation 474 days (349-715). 13 (28%) patients were resuscitated from dysautonomic cardiac arrest. After a median of 5 years (IQR 3-7), 15 (33%) of 45 patients completely recovered (mRS score ≤1 and returned to all previous activities), 13 (29%) substantially improved (mRS score 2), 11 (24%) had mRS score 3-5, and six (13%) died. Five patients began command-following a median of 11 months (IQR 2-21) after last immunotherapy. Estimated cumulative incidence for reaching an mRS score of 2 was 66% at 5 years and 76% at 10 years, and for recovery was 32% at 5 years and 54% at 10 years. Teratomas were associated with a lower probability of reaching mRS score 2 (sub-distribution hazard ratio 0·39 [95% CI 0·18-0·84], p=0·0160), whereas older age (1·10 per year [1·04-1·23], p=0·0052) and higher NMDAR encephalitis 1-Year Functional Status (NEOS)2 score (1·51 [1·12-2·04], p=0·0072) were associated with increased mortality. In people with NMDAR encephalitis and prolonged impairment of consciousness, full or substantial recovery was reached in approximately two-thirds of cases. Consequently, early assessment of treatment response or refractoriness might underestimate delayed improvement, prolonged therapy needs, or spontaneous recovery. Futility decisions should therefore be individualised with multidisciplinary input and based on extended follow-up. Instituto de Salud Carlos III and Fundació La Caixa.
Determinants of disease severity and 12-month functional outcome in pediatric ovarian Teratoma-Associated Anti-NMDA receptor encephalitis.
Pediatric ovarian teratoma-associated anti-N-methyl-D-aspartate receptor encephalitis (NMDARE) represents a clinically important but relatively uncommon subgroup, and evidence regarding factors associated with acute severity and long-term functional outcome in this population remains limited. We conducted a single-center retrospective cohort study of pediatric patients with surgically resected, histopathologically confirmed ovarian teratoma-associated NMDARE. Baseline and acute-phase characteristics were summarized in the full cohort (N = 97). Acute severity was defined by ICU admission with organ support and/or mechanical ventilation. Twelve-month functional outcome was assessed using the modified Rankin Scale (mRS) and dichotomized as good (mRS≤2) versus poor (mRS>2); outcome analyses were performed in the complete-case cohort (N = 71). Univariable and multivariable logistic regression identified factors independently associated with poor outcome. Discriminative performance was evaluated using ROC curve analysis. Among 97 patients, median age at onset was 14.2 years (IQR 12.3-16.5) and 95.9% were female. Mature teratoma accounted for 80.4%. The median onset-to-resection interval was 18 days (IQR 11-29), and 34.0% underwent resection >21 days after onset. Severe disease occurred in 29 patients (29.9%) and was associated with higher symptom burden (median symptom categories 5.0 vs 3.0, P < 0.001), more frequent MRI abnormalities (62.1% vs 33.8%, P = 0.009) and multifocal MRI lesions (27.6% vs 7.4%, P = 0.013), and higher rates of EEG background slowing (89.7% vs 61.8%, P = 0.014) and extreme delta-brush (44.8% vs 13.2%, P = 0.001). In the 12-month outcome cohort (N = 71), 76.1% achieved mRS≤2 and 23.9% had mRS>2; relapse occurred in 8.5% and death in 2.8%. Multivariable analysis identified central hypoventilation (aOR 4.18, 95%CI 1.62-10.78), symptom categories ≥4 (aOR 2.94, 1.14-7.61), multifocal MRI lesions (aOR 3.12, 1.01-9.65), extreme delta-brush (aOR 3.37, 1.18-9.63), and onset-to-resection >21 days (aOR 2.81, 1.05-7.49) as independent correlates of poor functional outcome. The combined clinical plus imaging-EEG model showed the highest discrimination (AUC 0.86, 95%CI 0.76-0.95), with sensitivity 88.2% and specificity 74.1% at the optimal cutoff. In pediatric ovarian teratoma-associated NMDARE, higher acute-phase clinical burden, multifocal MRI abnormalities, extreme delta-brush, central hypoventilation, and delayed tumor resection were independently associated with poor 12-month functional outcome.
Transition Readiness and Care Needs Among Youth With Neuroimmune Disorders: A Descriptive Survey Study.
Transition of care (TOC) poses challenges across medical subspecialties, each with distinct patient needs. Understanding patient and caregiver awareness and readiness within specific patient populations is essential for developing effective population-specific TOC programs. Limited data exist describing TOC readiness in patients with neuroimmune disorders. We conducted a cross-sectional survey on youth with neuroimmune disorders and their caregivers assessing TOC readiness, challenges, and support needs. Thirty-one participants completed the survey (39% Hispanic, 29% Caucasian, 19% African American). Respondents with MOG antibody-associated disease (29%), multiple sclerosis (26%), and anti-N-methyl-d-aspartate (anti-NMDA) receptor encephalitis (10%) were represented in this study. Eighty-three percent of caregivers reported their child was not ready for transition, whereas 32% of patients described feeling curious about TOC. The primary concern for both patients (53%) and caregivers (65%) was that adult providers would be unfamiliar with the patient's history. The most common patient-perceived readiness gaps included lack of knowledge of clinic information (81%), not having an emergency plan (77%), and poor understanding of insurance changes (81%). The most frequent patient-reported facilitators were access to an educational curriculum (35%) or a dedicated transition appointment (35%). More than half of patients (52%) and caregivers (61%) preferred a continuity-provider TOC model, and most supported participation in TOC support groups (55% of patients, 87% of caregivers). To conclude, significant gaps exist in TOC readiness among the neuroimmune disorder population. Key facilitators include structured education, provider continuity, and support programming-elements that could strengthen preparedness, reduce care disruption, and increase confidence in navigating adult health care systems.
Therapeutic perspectives in refractory anti-NMDA receptor encephalitis.
Epilepsia partialis continua as an isolated manifestation of anti-NMDA receptor encephalitis: a case report.
Publicações recentes
When imaging fails: surgical discovery of an occult ovarian teratoma in severe refractory anti-NMDA receptor encephalitis.
Reversible Splenial Lesion Syndrome Due to Anti-NMDA Receptor Encephalitis Manifesting as Delusional Disorder: A Case Report and Literature Review.
The role of brain MRI in autoimmune encephalitis.
Glioblastoma mimicking anti-NMDA receptor encephalitis: a case series.
Anti-NMDAR encephalitis impairs intrinsic hippocampal dynamics through neuronal hypercoupling, hub dominance, and aberrant ensembles.
📚 EuropePMC702 artigos no totalmostrando 198
Complications, outcomes, and implications of a prolonged vegetative state in anti-NMDA receptor encephalitis: a retrospective international cohort study.
The Lancet. NeurologyTherapeutic perspectives in refractory anti-NMDA receptor encephalitis.
The Lancet. NeurologyAnti-NMDA receptor encephalitis in the setting of inherited chromosomally integrated human herpesvirus 6B (iciHHV-6B): A case report.
IDCasesRefractory anti-NMDA receptor encephalitis driven by a contralateral ovarian teratoma following unilateral oophorectomy: a case report.
International journal of surgery case reportsCAR T cell therapy in autoantibody-mediated neurological disorders: a promising strategy.
Journal of neuroinflammationNeuropsychiatric Systemic Lupus Erythematosus Diagnosed Following Treatment Initiated for Acute Encephalitis.
CureusDeterminants of disease severity and 12-month functional outcome in pediatric ovarian Teratoma-Associated Anti-NMDA receptor encephalitis.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology SocietyExtreme delta brush EEG pattern in anti-NMDA receptor encephalitis.
QJM : monthly journal of the Association of PhysiciansAbnormal Magnetic Resonance Imaging Patterns in Patients with Neuropsychiatric Disorders Due to Anti-NMDA Receptor Encephalitis: A Comparative Study.
Diagnostics (Basel, Switzerland)Anti-NMDA Receptor Encephalitis Presenting as Acute Psychosis.
Clinical case reportsTwo Cases of vNOTES Assisted Vaginal Adnexectomy in Management of Paraneoplastic Anti-N-Methyl-D-Aspartate Receptor Encephalitis Secondary to Ovarian Teratoma.
Asian journal of endoscopic surgeryEpilepsia partialis continua as an isolated manifestation of anti-NMDA receptor encephalitis: a case report.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyAnti-NMDA receptor encephalitis unmasking Sjögren's disease: a case report and literature review.
Frontiers in immunologyTransition Readiness and Care Needs Among Youth With Neuroimmune Disorders: A Descriptive Survey Study.
Journal of child neurologyTrapped in Silence: Severe Catatonia From Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis in a Neurofibromatosis Type 1 Patient With Craniopharyngioma.
CureusImmature ovarian teratomas in anti-NMDA receptor encephalitis.
Journal of neuroimmunologyImmune involvement in neuropsychiatric disorders: Insights from single-cell transcriptomic studies.
Psychiatry and clinical neurosciencesElectroencephalography, microRNA, and anti-NMDA receptor encephalitis.
Clinica chimica acta; international journal of clinical chemistryAnti-NMDA receptor encephalitis with coexisting autoimmune GFAP astrocytopathy presenting with psychiatric symptoms leading to a suicide attempt: a case report.
International journal of emergency medicineLife-Threatening Bradycardia in Anti-NMDA-Receptor Encephalitis and a Novel Use for Permanent Pacing.
Annals of clinical and translational neurologyPaediatric myelin oligodendrocyte glycoprotein antibody-associated disease with NMDA receptor encephalitis: overlap syndrome and challenges in the antibody testing.
BMJ case reports[Clinical challenge in anti-NMDA receptor encephalitis-A psychiatric case report].
Der NervenarztComparison of the Efficacy of Polyvalent Intravenous Immunoglobulins and Therapeutic Plasma Exchange in Anti-NMDAR Encephalitis in the ICU.
Neurocritical careSevere anti-NMDA receptor encephalitis in a pediatric patient presenting with status dystonicus as the primary clinical manifestation: A case report (CARE).
MedicineCharacterizing CSF inflammatory proteomics in pediatric post-hemorrhagic hydrocephalus and Anti-NMDAR encephalitis.
Journal of neuroinflammationDeciphering the molecular landscape of NMDAR-E associated ovarian teratomas: a Multi-Omics approach.
Journal of ovarian researchAnti-NMDA receptor encephalitis following Murray Valley encephalitis: a case report.
ASM case reportsAssociation between visual hallucinations and α-synuclein oligomers in patients with dementia with Lewy bodies.
Alzheimer's & dementia : the journal of the Alzheimer's AssociationCombination therapy of ofatumumab and daratumumab in patients with severe anti-NMDA receptor encephalitis.
Frontiers in immunologyDiagnostic Challenges in a Patient With Systemic Lupus Erythematosus (SLE) and Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis: A Case Report.
CureusN-Methyl-D-Aspartate (NMDA) Receptor Encephalitis Without Electroencephalogram Abnormalities or Cerebrospinal Fluid Pleocytosis Associated With a Tiny Ovarian Teratoma: A Case Report.
CureusParaneoplastic Anti-NMDA Receptor Encephalitis in a Nigerian Female Teenager: A Case Report.
Nigerian medical journal : journal of the Nigeria Medical AssociationAutoimmune neuropsychiatric disorders manifesting with psychosis.
The Journal of clinical investigationSystemic Complications of Status Epilepticus.
Current neurology and neuroscience reportsSeronegative but Cerebrospinal Fluid-positive NMDA Receptor Encephalitis in an Alzheimer's Dementia Patient with Good Treatment Outcome: A Case Report.
Acta neurologica TaiwanicaChild Neurology: Parainfectious Anti-NMDAR Encephalitis With Anti-MOG and Anti-AQP4 Seropositivity in an Infant.
NeurologyElectroconvulsive Therapy for Catatonia in NMDA Receptor Encephalitis Unresponsive to Immunotherapy in a Five Year Old.
PediatricsAtypical Anti-NMDAR encephalitis presenting with pharyngeal-cervical-bibrachial weakness: A rare case report.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyAcquired epileptic aphasia in NMDA encephalitis: a unique electroclinical presentation with pathophysiological considerations.
BMJ case reportsA case of anti-N-methyl-D-aspartate receptor encephalitis with associated ovarian teratoma in a 23-year-old female.
Radiology case reportsNeurochemical and molecular characteristics of altered brain functional activity in the anti-NMDAR encephalitis.
Neurobiology of diseasePosterior Reversible Encephalopathy Syndrome: A Case Report With Contemporary Literature Review and Neuropathological Evidence From Autopsy.
CureusAnti-NMDA receptor encephalitis following SARS-CoV-2 infection in children.
Diagnostic microbiology and infectious diseaseAnti-NMDA receptor encephalitis in a patient with 18p deletion syndrome.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiquesBrain Metabolite Levels in the Post-Acute Stage of Anti-NMDA Receptor Encephalitis and Schizophrenia: A Longitudinal Case-Control Study.
Biological psychiatryAnti-N-methyl-ᴅ-aspartate receptor encephalitis preceding stroke: report of an unusual case with literature review.
Encephalitis (Seoul, Korea)Mind in Crisis, Ovary in Question: A Case of Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis Associated With Ovarian Teratoma.
CureusNMDAR autoimmune encephalitis associated with Sjögren's syndrome.
BMJ case reportsMonoclonal humanized monovalent antibody blocking therapy for anti-NMDA receptor encephalitis.
Nature communicationsAnti-NMDA Receptor Encephalitis in the Setting of an Immature Ovarian Teratoma: A Case Report and Literature Review.
Case reports in obstetrics and gynecologyAnti-NMDA receptor encephalitis in a child with H3K27M mutant pontine diffuse midline glioma.
BMJ case reportsStriking pattern on [18F]FDG PET/CT in anti-NMDA receptor encephalitis.
Revista espanola de medicina nuclear e imagen molecularAn updated, comprehensive meta-analysis of the treatment of anti-NMDAR encephalitis: Analysis, equipoise, and the urgent need for evidence over anecdote.
Journal of neuroimmunologyReversal of profound cortical atrophy with immunotherapy in pediatric anti-NMDA receptor encephalitis.
Journal of neuroimmunologyAnti-NMDA Receptor Encephalitis: A Narrative Review.
Brain sciencesAtypical Autoimmune Encephalitis: Diagnostic Challenges and Therapeutic Insights From a Case Series.
CureusRisk factors for poor response to initial first-line immunotherapy and subsequent immunotherapy on prognosis in pediatric anti-NMDA receptor encephalitis.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyThe Clinical Significance of Abnormal Electroencephalography (EEG) Patterns in Patients with Neuropsychiatric Disorders Due to Anti-NMDA Receptor Encephalitis: A Comparative Study.
Diagnostics (Basel, Switzerland)Development of anti-NMDA receptor encephalitis in a patient with multiple sclerosis.
BMJ case reportsSpectrum of Neurological Manifestations of HHV-6 Encephalitis in Immunocompetent Children - A Retrospective Study at a Tertiary Care Center in South India.
Annals of Indian Academy of NeurologyAutoimmune psychosis: Psychopathological patterns and outcome after immunotherapy.
Schizophrenia researchA case report of NMDAR encephalopathy - A neurologic condition that a gynecologist can cure.
International journal of surgery case reportsRed flag: A notable proportion of anti-NMDAR encephalitis cases may be admitted to psychiatric units in general hospitals.
General hospital psychiatryGTE score on evaluating the degree of neurological impairment in anti-NMDA receptor encephalitis.
Scientific reportsComparative analysis of new-onset refractory status epilepticus in adult and pediatric patients: immunotherapy timing and functional outcomes.
Journal of neurologyLongitudinal Evolution of Posterior Cortical Atrophy: Diagnostic Delays, Overlapping Phenotypes, and Clinical Outcomes.
NeurologyDouble Trouble: Herpes Simplex Encephalitis Triggering Autoimmune Encephalitis.
CureusRecurrent anti-NMDA receptor encephalitis in first-trimester pregnancy with initially antibody-negative CSF.
Journal of neuroimmunologyDiagnosis and Management of Children With Atypical Neuroinflammation.
NeurologySuccessful Treatment of Anti-N-Methyl-D-Aspartate Receptor Encephalitis With Bilateral Ovarian Teratomas Through Three Surgeries Without Loss of Fertility.
CureusA Case of Anti-N-Methyl-D-Aspartate Receptor (NMDAR) Encephalitis With Video-Documented Psychogenic Nonepileptic Seizures (PNES)-Mimicking Episodes Initially Considered as Somatic Symptom Disorder.
CureusCurrent and emerging therapies for autoimmune encephalitis.
Expert review of neurotherapeuticsSafety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open-label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU trial.
The Lancet. NeurologyImmunotherapy-responsive parkinsonism and anosmia in anti-NMDA receptor encephalitis with seropositive NMOSD: A case report.
Journal of the neurological sciencesA Complex Case of Triumphantly Treated Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis.
CureusLong-term maintenance of mycophenolate mofetil in anti-NMDA receptor encephalitis (LEARN): a multicentre, open-label, blinded-endpoint, randomised controlled trial.
Journal of neurology, neurosurgery, and psychiatryAbnormal Brain MRI in Anti-NMDA Receptor Encephalitis: Clinical and Prognostic Implications.
Neurology(R) neuroimmunology & neuroinflammationTime moving 100-fold slower: time distortion as a diagnostic clue in anti-NMDA receptor encephalitis.
BMC neurologySuccessful sequential therapy with rituximab and telitacicept in refractory Anti-NMDA receptor encephalitis and MOG-associated demyelination: a case report and literature review.
Frontiers in immunologySafety and efficacy of long-term gantenerumab treatment in dominantly inherited Alzheimer's disease: an open label extension of the phase 2/3 multicentre, randomised, double-blind, placebo-controlled platform DIAN-TU Trial.
medRxiv : the preprint server for health sciencesSuccessful treatment with efgartigimod as an add-on therapy for acute attack of anti-NMDA receptor encephalitis: a case report.
BMC neurologyClinical Analysis of MOG Antibody-Associated Disease Overlapped With Anti-NMDA Receptor Encephalitis: A Long-Term Retrospective Study.
The European journal of neuroscienceSeizures and status epilepticus in anti-NMDA receptor encephalitis.
Journal of neurologyMolecular scalpels dissect new GluN1 hot spots in anti-NMDA receptor encephalitis.
Science immunologyPrecision Assessment of Anti-NMDA Receptor Encephalitis: A Case Report on Integrating Clinical Course, Immunophenotyping, and Comprehensive Symptomatology in a Pediatric Patient With Adjunctive Hydrogen Therapy.
In vivo (Athens, Greece)Neuro-immunobiology and treatment assessment in a mouse model of anti-NMDAR encephalitis.
Brain : a journal of neurologyAsymmetric Bilateral Medial Temporal Lobe Encephalitis Associated With Anti-N-Methyl-D-Aspartate (NMDA) Receptor Antibodies: A Case Report.
CureusLong-Term Clinical and Biological Prognostic Factors of Anti-NMDA Receptor Encephalitis in Children.
Neurology(R) neuroimmunology & neuroinflammationCatatonia As Initial Presentation in Anti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis: A Case Report of a 19-Year-Old Patient.
CureusEvidence-based diagnostic prediction score for pediatric NMDA receptor encephalitis.
European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology SocietyTo analyze the efficacy and safety of plasma exchange in the treatment of anti-NMDA receptor encephalitis.
Therapeutic apheresis and dialysis : official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis TherapyPatient-Reported Outcome Measures in NMDA Receptor Encephalitis.
Neurology(R) neuroimmunology & neuroinflammationAnti-N-methyl-D-aspartate receptor encephalitis following Human norovirus infection: A case report.
Diagnostic microbiology and infectious diseaseAnti-NMDA Receptor Encephalitis Presenting with Prosopagnosia.
Annals of Indian Academy of NeurologyAlternative treatment in adolescent with anti-NMDA receptor encephalitis catatonia.
NeurocaseANTI -NMDA RECEPTOR ENCEPHALITIS: A POSSIBLE APPROACH TO DEVELOP A COST-EFFECTIVE TEST FOR ANTI NMDA RECEPTOR ANTIBODY DETECTION.
Journal of Ayub Medical College, Abbottabad : JAMCWhen the Mind Fails: A Mysterious Case of Concurrent Neurosyphilis, Herpes Simplex Virus Encephalitis, and Suspected Autoimmune Encephalitis.
CureusAnti-NMDA receptor autoimmune encephalitis associated with ovarian teratoma: A case series and literature review.
International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and ObstetricsOligoclonal IgG bands revealed to be constituted with NMDAR autoantibodies in a patient with anti-NMDA receptor encephalitis.
Journal of the neurological sciencesCatatonia in anti-NMDA receptor encephalitis: a case series and approach to improve outcomes with electroconvulsive therapy.
BMJ neurology openForme-Fruste of Anti-NMDA Receptor Encephalitis: Sydenham's Chorea Mimic.
Indian journal of pediatricsEncephalitis lethargica: clinical features and aetiology.
Brain communicationsEditors' Note: Teaching NeuroImage: Anti-NMDA Receptor Encephalitis Presenting With Cerebellitis in a Pediatric Patient.
NeurologyReader Response: Teaching NeuroImage: Anti-NMDA Receptor Encephalitis Presenting With Cerebellitis in a Pediatric Patient.
NeurologyMRI findings in autoimmune encephalitis.
Revue neurologiqueConsensus recommendations for clinical assessment tools for the diagnosis of posterior cortical atrophy syndrome from the Atypical AD PIA of ISTAART.
Alzheimer's & dementia (Amsterdam, Netherlands)From Psychosis to Recovery: A Case Report of N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis.
CureusAnti-N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis Secondary to an Ovarian Dermoid Cyst.
CureusAssessment of long-term psychosocial outcomes in N-methyl-D-aspartate receptor encephalitis - the SAPIENCE study protocol.
BMC neurologyAnti-N-Methyl-D-Aspartate Receptor Encephalitis and Life-Threatening Sinus Node Dysfunction: A Case Report, Literature Review, and Analysis of 23 Cases.
CureusA short-term functional recovery comparison of therapeutic plasma exchange and immunoadsorption in severe acute neuroimmune diseases.
International immunopharmacologyIsolated Psychiatric Symptoms in Children With Anti-N-Methyl-d Aspartate Receptor Encephalitis.
Pediatric neurologyEigenvector Centrality Mapping Reveals Volatility of Functional Brain Dynamics in Anti-NMDA Receptor Encephalitis.
Biological psychiatry. Cognitive neuroscience and neuroimagingAutoimmune 'secondary synaptopathies': do NMDAR antibodies cause a primary extra-synaptopathy?
Brain : a journal of neurologyCorrespondence: Electroconvulsive therapy in N-methyl-D-aspartate receptor encephalitis.
Journal of neuroimmunologyAn elderly case of paraneoplastic anti-NMDA receptor encephalitis associated with large cell neuroendocrine carcinoma of the lung.
BMC pulmonary medicineHippocampal hub failure is linked to long-term memory impairment in anti-NMDA-receptor encephalitis: insights from structural connectome graph theoretical network analysis.
Journal of neurologyExamining Associations Between Smartphone Use and Clinical Severity in Frontotemporal Dementia: Proof-of-Concept Study.
JMIR agingREM and NREM Sleep Parasomnia in Anti-NMDA Receptor Encephalitis.
Neurology(R) neuroimmunology & neuroinflammation[A case report of anti-NMDA receptor encephalitis with mental disturbances manifestation].
Zhurnal nevrologii i psikhiatrii imeni S.S. KorsakovaAutoimmune-associated seizure disorders.
Epileptic disorders : international epilepsy journal with videotapeAberrant Brain Networks and Relative Band Power in Patients with Acute Anti-NMDA Receptor Encephalitis: A Study of Resting-State EEG.
Journal of integrative neuroscienceMemory loss and aberrant neurogenesis in mice exposed to patient anti-N-methyl-d-aspartate receptor antibodies.
Experimental neurologyCase report: Isolated brainstem-cerebellar symptoms in a patient with anti-NMDA receptor encephalitis.
Frontiers in immunologyMolecular neuroimaging in dominantly inherited versus sporadic early-onset Alzheimer's disease.
Brain communicationsH-intensity scale score to estimate CSF GluN1 antibody titers with one-time immunostaining using a commercial assay.
Frontiers in immunologyAnti-NMDA encephalitis secondary to an ovarian teratoma presenting as altered mental status in a 32-year-old woman: A case report.
Case reports in women's healthRacial and Ethnic Disparities in the Incidence of Anti-NMDA Receptor Encephalitis.
Neurology(R) neuroimmunology & neuroinflammationA case report of anti-NMDA receptor encephalitis in a 23-year-old female with acute psychiatric symptoms.
Clinical case reportsRegional cerebral blood flow in a patient with asystole episodes associated with anti-NMDA receptor encephalitis.
NeurocaseAnti-NMDA Receptor Encephalitis Related to Renal Cell Carcinoma: A Case Report.
The Neurohospitalist[Late recognition of anti-NMDA receptor encephalitis: the effect of a one-track mind in multiple specialties].
Tijdschrift voor psychiatrieVery Long-Term Functional Outcomes and Dependency in Children With Anti-NMDA Receptor Encephalitis.
Neurology(R) neuroimmunology & neuroinflammationAnti-NMDA Receptor Encephalitis, Human Papillomavirus, and microRNA.
Current medicinal chemistryUnveiled: A Case of N-Methyl-D-Aspartate Receptor Antibody Encephalitis With Delayed Diagnosis of Ovarian Teratoma.
CureusClinicoradiological and neuropathological evaluation of primary progressive aphasia.
Journal of neurology, neurosurgery, and psychiatryTeaching NeuroImage: Anti-NMDA Receptor Encephalitis Presenting With Cerebellitis in a Pediatric Patient.
NeurologyCase report: Rapid recovery after intrathecal rituximab administration in refractory anti-NMDA receptor encephalitis: report of two cases.
Frontiers in immunologyParaneoplastic encephalitis.
Handbook of clinical neurologyMyD88-mediated signaling is critical for the generation of seizure responses and cognitive impairment in a model of anti-N-methyl-D-aspartate receptor encephalitis.
Epilepsia[Paraneoplastic Anti-N-methyl-D-aspartate Receptor Encephalitis Associated with Anterior Mediastinal Mature Teratoma].
Kyobu geka. The Japanese journal of thoracic surgeryPossible temporal relationship between SARS-CoV-2 infection and anti-NMDA receptor encephalitis: a meta-analysis.
Translational psychiatryAnti-NMDA receptor encephalitis presenting as aseptic meningitis.
Irish medical journalMapping the global research landscape and trends of autoimmune encephalitis: A bibliometric analysis.
HeliyonBlood and CSF findings of cellular immunity in anti-NMDAR encephalitis.
International immunopharmacologyAnti-NMDA-receptor encephalitis and concurrent neuroborreliosis misdiagnosed for post-COVID-19-syndrome: a case report.
Therapeutic advances in neurological disordersExamining amyloid reduction as a surrogate endpoint through latent class analysis using clinical trial data for dominantly inherited Alzheimer's disease.
Alzheimer's & dementia : the journal of the Alzheimer's AssociationOvarian teratoma-associated anti-NMDA receptor encephalitis with severe features.
BMJ case reportsSignificant efficacy of electroconvulsive therapy on the behavioural symptoms of anti-N-methyl-d-aspartate receptor encephalitis.
BMJ case reportsLongitudinal Disability, Cognitive Impairment, and Mood Symptoms in Patients With Anti-NMDA Receptor Encephalitis.
NeurologyAnti-NMDA receptor encephalitis presenting as a progression of disease in a patient with underlying congenital leukodystrophy: Case report.
The NeurohospitalistOcular Electrophysiologic Studies in a Patient With Anti-NMDA Receptor Encephalitis and Visual Dysfunction: A Case Report.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology SocietyCortical atrophy in early-stage patients with anti-NMDA receptor encephalitis: a machine-learning MRI study with various feature extraction.
Cerebral cortex (New York, N.Y. : 1991)Electroconvulsive therapy for catatonia in anti-NMDA receptor encephalitis: A case series.
Journal of neuroimmunologyExamining the Features of Neuroleptic Malignant Syndrome in Anti-NMDA Receptor Encephalitis: A Case-Control Study.
Journal of the Academy of Consultation-Liaison PsychiatryThe Patient Perspective in Encephalitis Research.
Neurology(R) neuroimmunology & neuroinflammationParaneoplastic Neurologic Syndromes.
Continuum (Minneapolis, Minn.)Single-cell RNA sequencing reveals diverse B cell phenotypes in patients with anti-NMDAR encephalitis.
Psychiatry and clinical neurosciencesRecurrent Anti-NMDA Receptor Encephalitis After Mycoplasma Pneumonia Infection.
The American journal of psychiatryIntestinal dysbiosis exacerbates susceptibility to the anti-NMDA receptor encephalitis-like phenotype by changing blood brain barrier permeability and immune homeostasis.
Brain, behavior, and immunityOfatumumab, a Fully Human Anti-CD20 Monoclonal Antibody, in the Treatment of Severe Refractory Anti-N-methyl-D-Aspartate Receptor Encephalitis: Two Case Reports.
Annals of Indian Academy of NeurologyTeratoma pathology and genomics in anti-NMDA receptor encephalitis.
Annals of clinical and translational neurologyBrazilian autoimmune encephalitis network (BrAIN): antibody profile and clinical characteristics from a multicenter study.
Frontiers in immunologyElevated phospholipids and acylcarnitines C4 and C5 in cerebrospinal fluid distinguish viral CNS infections from autoimmune neuroinflammation.
Journal of translational medicineChimeric autoantibody receptor T cells deplete NMDA receptor-specific B cells.
CellT1 and FLAIR signal intensities are related to tau pathology in dominantly inherited Alzheimer disease.
Human brain mappingHero or Antagonist: A Case Series on the Tolerability of Memantine as Salvage Therapy for Catatonia from Anti-NMDA Receptor Encephalitis.
Harvard review of psychiatryPathogenic variants in the Longitudinal Early-onset Alzheimer's Disease Study cohort.
Alzheimer's & dementia : the journal of the Alzheimer's AssociationThe T1-weighted/T2-weighted ratio as a biomarker of anti-NMDA receptor encephalitis.
Journal of neurology, neurosurgery, and psychiatryA Multimedia Description of Catatonia Secondary to Anti-NMDA-Receptor Encephalitis.
The primary care companion for CNS disordersHuman NMDAR autoantibodies disrupt excitatory-inhibitory balance, leading to hippocampal network hypersynchrony.
Cell reportsInvestigation of sex differences in mutation carriers of the Dominantly Inherited Alzheimer Network.
Alzheimer's & dementia : the journal of the Alzheimer's AssociationGlucocorticoid-dependent multiple sclerosis overlapping anti-NMDA receptor encephalitis: a case report and literature review update.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyVH2+ Antigen-Experienced B Cells in the Cerebrospinal Fluid Are Expanded and Enriched in Pediatric Anti-NMDA Receptor Encephalitis.
Journal of immunology (Baltimore, Md. : 1950)Temporal transformer-spatial graph convolutional network: an intelligent classification model for anti N-methyl-D-aspartate receptor encephalitis based on electroencephalogram signal.
Frontiers in neuroscienceAmyloid and tau-PET in early-onset AD: Baseline data from the Longitudinal Early-onset Alzheimer's Disease Study (LEADS).
Alzheimer's & dementia : the journal of the Alzheimer's AssociationA small mature cystic ovarian teratoma associated with anti-NMDA receptor encephalitis and acute respiratory failure: A case report.
Taiwanese journal of obstetrics & gynecologyAnti-NMDA receptor encephalitis in a 73-year-old female with secondary progressive multiple sclerosis: A case report.
Epilepsy & behavior reportsControversies in immunotherapy for anti-NMDA receptor encephalitis: a scoping review with a proposal of operational definitions.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyAssociation of Plasma Biomarkers of Alzheimer Disease With Cognition and Medical Comorbidities in a Biracial Cohort.
NeurologyAnti-N-Methyl-D-Aspartate Receptor Encephalitis With Diffuse Demyelinating Plaques: A Case Report of an Atypical Presentation.
CureusAge-Specific Barriers and Facilitators to Research Participation Amongst African Americans in Observational Studies of Memory and Aging.
Journal of racial and ethnic health disparitiesBrain rhythmic abnormalities in convalescent patients with anti-NMDA receptor encephalitis: a resting-state EEG study.
Frontiers in neurologyThe relevance of NMDA receptor antibody-specific index for diagnosis and prognosis in patients with anti-NMDA receptor encephalitis.
Scientific reportsClinico-Etiological Spectrum and Functional Outcomes of Children with Pre-Status Dystonicus and Status Dystonicus (SD): A Descriptive Study.
Annals of Indian Academy of NeurologyCase report: Coexistence of Labbe vein thrombosis and autoimmune encephalitis with two different antibodies.
Frontiers in neurologyOptimizing animal models of autoimmune encephalitis using active immunization.
Frontiers in immunologySensitivity and specificity of alternative screening methods for systematic reviews using text mining tools.
Journal of clinical epidemiologyCerebrospinal fluid biomarkers in the Longitudinal Early-onset Alzheimer's Disease Study.
Alzheimer's & dementia : the journal of the Alzheimer's AssociationElevated blood and cerebrospinal fluid biomarkers of microglial activation and blood‒brain barrier disruption in anti-NMDA receptor encephalitis.
Journal of neuroinflammationAnti-N-methyl D-aspartate receptor encephalitis presenting with the new-onset refractory status epilepticus.
Northern clinics of IstanbulPositron emission tomography and magnetic resonance imaging methods and datasets within the Dominantly Inherited Alzheimer Network (DIAN).
Nature neuroscienceEffectiveness of intra-thecal methotrexate in refractory Anti-N-methyl-d-aspartate receptor encephalitis.
BMC neurologyAbundant infiltration of B cells and plasma cells in brain biopsy of a male patient with severe anti-NMDA receptor encephalitis: A case report.
MedicineAdjunctive Memantine for Catatonia Due to Anti-NMDA Receptor Encephalitis.
The Journal of neuropsychiatry and clinical neurosciencesAcute pediatric encephalitis: etiology, course, and outcome of a 12-year single-center immunocompetent cohort.
Journal of neurologyAnti-NMDAR encephalitis in Southeast Asia - A single-centre, longitudinal study.
Clinical neurology and neurosurgeryAnti-amyloid therapies for Alzheimer disease: finally, good news for patients.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Complications, outcomes, and implications of a prolonged vegetative state in anti-NMDA receptor encephalitis: a retrospective international cohort study.
- Determinants of disease severity and 12-month functional outcome in pediatric ovarian Teratoma-Associated Anti-NMDA receptor encephalitis.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society· 2026· PMID 41740198mais citado
- Transition Readiness and Care Needs Among Youth With Neuroimmune Disorders: A Descriptive Survey Study.
- Therapeutic perspectives in refractory anti-NMDA receptor encephalitis.
- Epilepsia partialis continua as an isolated manifestation of anti-NMDA receptor encephalitis: a case report.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology· 2026· PMID 41622303mais citado
- When imaging fails: surgical discovery of an occult ovarian teratoma in severe refractory anti-NMDA receptor encephalitis.
- Reversible Splenial Lesion Syndrome Due to Anti-NMDA Receptor Encephalitis Manifesting as Delusional Disorder: A Case Report and Literature Review.
- The role of brain MRI in autoimmune encephalitis.
- Glioblastoma mimicking anti-NMDA receptor encephalitis: a case series.
- Anti-NMDAR encephalitis impairs intrinsic hippocampal dynamics through neuronal hypercoupling, hub dominance, and aberrant ensembles.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:217253(Orphanet)
- MONDO:0021081(MONDO)
- GARD:20513(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q55786136(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
