Tumor neuroblástico benigno do sistema nervoso simpático que ocorre na infância. O ganglioneuroma normalmente surge do tronco simpático no mediastino. As características histológicas incluem proliferação de células fusiformes (semelhante a um neurofibroma) e a presença de grandes células ganglionares. As características comuns incluem massa abdominal palpável, hepatomegalia e massa torácica detectada na radiografia de tórax de rotina.
Introdução
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Tumor neuroblástico benigno do sistema nervoso simpático que ocorre na infância. O ganglioneuroma normalmente surge do tronco simpático no mediastino. As características histológicas incluem proliferação de células fusiformes (semelhante a um neurofibroma) e a presença de grandes células ganglionares. As características comuns incluem massa abdominal palpável, hepatomegalia e massa torácica detectada na radiografia de tórax de rotina.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
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Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 16 características clínicas mais associadas, ordenadas por frequência.
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição.
Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a nega
Cell membrane
Variantes genéticas (ClinVar)
4,870 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
11 vias biológicas associadas aos genes desta condição.
Diagnóstico
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Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
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Mostrando amostra de 200 publicações de um total de 644
[Correlation study between tumor location and pathological subtypes of neuroblastic tumors associated with opsoclonus myoclonus ataxia syndrome].
Objective: To analyze the correlation between the location and pathological subtypes of of neuroblastic tumors (NBT) associated with opsoclonus myoclonus ataxia syndrome (OMAS). Methods: A case-control study. Clinical data of 34 pediatric patients diagnosed with NBT complicated by OMAS (NBT-OMAS group), who were hospitalized in the Department of Pediatrics, Peking University First Hospital from January 2007 and December 2022 were collected retrospectively. The control group consisted of 34 age and sex-matched patients with NBT only (NBT-only group) admitted during the same period. Chi-square test or Fisher exact test was used to compare the distribution of tumor locations and pathological subtypes between the two groups. Cramer's V coefficient was applied to analyze the correlation between them. The outcomes of the patients were followed up. Results: The age of patients in the NBT-OMAS group was 18 (12, 28) months, while that of the NBT-only group was 20 (13, 31) months. In the NBT-OMAS group, 28 cases (82%) had tumors located in the paraspinal sympathetic chain and 6 cases (18%) in the adrenal glands. In the NBT-only group, 6 cases (18%) had tumors located in the adrenal glands and 28 cases (82%) in the paraspinal sympathetic chain, with a statistically significant difference between the two groups (χ2=10.69, P<0.01). The distribution of pathological subtypes of tumors in the NBT-OMAS group was as follows: 20 cases (59%) of ganglioneuroblastoma (GNB), 10 cases (29%) of neuroblastoma (NB), 4 cases (12%) of ganglioneuroma (GN). In the NBT-only group, NB was predominant with 21 cases (62%), GNB in 13 cases (38%), and no GN subtype was observed. There was a statistically significant difference between the two groups (χ2=8.59, P<0.01). In the NBT-OMAS group, the pathological subtype of tumors located in the adrenal gland was mainly NB, with 5 cases (5/6). For tumors located paravertebral to the thoracic and lumbar spine, the predominant subtype was GNB, with 8 cases (8/11) and 11 cases (11/13) respectively. As for tumors paravertebral to the sacral spine, the major subtype was NB, with 3 cases (3/4). In the NBT-only group, NB was the pathological subtype in 18 cases of adrenal gland tumors (18/19). For tumors paravertebral to the cervical spine, NB and GNB each accounted for 2 cases respectively (2/4). Tumors located paravertebral to the thoracic spine and paravertebral to the lumbar spine were all GNB for 5 cases (5/5), while those paravertebral to the sacral spine were all NB for 1 case (1/1). The Cramer's V coefficients of the tumor location and pathological subtype in the two groups were 0.65 and 0.81, respectively. The follow-up ended on December 31, 2023. In the NBT-OMAS group, 1 case had tumor recurrence and 1 case died due to tumor progression; both the recurrent and fatal tumors were located in the adrenal glands with the pathological subtype of NB. In the NBT-only group, 11 cases died of tumor progression, among which 8 cases had primary tumor located in the adrenal gland and with the pathological subtype of NB. Conclusions: In children with NBT-OMAS, tumors located in the paravertebral sympathetic chains are significantly more common than those in the adrenal gland, the pathological subtype of tumors was predominantly GNB. The tumor location was correlated with its pathological subtype. 目的: 分析并发眼阵挛肌阵挛共济失调综合征(OMAS)的神经母细胞肿瘤(NBT)肿瘤发生部位与病理亚型的相关性。 方法: 病例对照研究。收集2007年1月至2022年12月在北京大学第一医院儿科住院且明确诊断为NBT并发OMAS的34例患儿(NBT-OMAS组)临床资料,对照组为同期入院、年龄和性别都匹配的单纯NBT患儿34例(单纯NBT组),采用χ2 检验或Fisher确切概率法比较两组肿瘤发生部位、病理亚型的分布情况,通过Cramer′s V系数比较两者的相关性,随访患儿结局。 结果: NBT-OMAS组患儿年龄18(12,28)月龄,单纯NBT组年龄为20(13,31)月龄。NBT-OMAS组肿瘤发生于脊柱旁交感神经链者28例(82%)、肾上腺者6例(18%);单纯NBT组中发生于肾上腺和脊柱旁交感神经链者分别为19例(56%)和15例(44%),两组比较差异有统计学意义(χ2=10.69,P<0.01)。NBT-OMAS组肿瘤病理亚型分布为节细胞神经母细胞瘤(GNB)20例(59%),神经母细胞瘤(NB)10例(29%),节细胞神经瘤(GN)4例(12%);单纯NBT组病理类型主要为NB 21例(62%),GNB 13例(38%),无GN亚型,两组比较差异有统计学意义(χ2=8.59,P<0.01)。NBT-OMAS组中,6例肿瘤位于肾上腺者中5例为NB;11例位于胸椎旁者中8例为GNB;13例位于腰椎旁者中11例为GNB;4例位于骶椎旁者中3例为NB。单纯NBT组中,19例肿瘤位于肾上腺中18例为NB;4例位于颈椎旁者中NB和GNB各占2例;5例位于胸椎旁和5例位于腰椎旁者均为GNB;1例位于骶椎旁者为NB。两组肿瘤所在部位与其病理亚型的Cramer′s V系数分别为0.65、0.81。随访截至2023年12月31日,NBT-OMAS组1例肿瘤复发、1例因肿瘤进展死亡,肿瘤均位于肾上腺且病理亚型为NB;单纯NBT组有11例因肿瘤进展死亡,其中8例原发肿瘤位于肾上腺且病理亚型为NB。 结论: NBT-OMAS患儿肿瘤发生于脊柱旁交感神经链者明显多于肾上腺者;肿瘤病理亚型以GNB者为主;肿瘤发生部位与其病理亚型相关。.
Dysplastic cerebellar gangliocytoma: a six-decade study.
Dysplastic cerebellar gangliocytoma (DCG) is a rare cerebellar tumor glioneuronal and neuronal tumor with phosphatase and tensin homolog (PTEN) identified as a key altered gene. The aim of this study is to establish DCG diagnostic and outcome trends over a six-decade and present cases from our institution. A literature review of online databases was performed using relevant terms (January 1970-October 2024). Our institution pathology database was queried for patients with DCG (2000-2024). Data was extracted and dichotomized in adult and pediatric cases. We report three new DCG cases in addition to the 170 DCG cases reported across 97 articles over seven decades, with 52% of articles published since 2010. DCG predominantly occurred in adults (>18 years, 82%), women (59%), at mean age 9.0±6.3 years and 38.1±13.7 years in pediatric and adult patients, respectively. Balance/coordination deficit, headache and visual deficit were the most common presenting symptoms. MRI "tiger-stripe" pattern was present in 67%. Surgical resection was the treatment of choice for >97% of patients. Association with Cowden Syndrome (CS) was confirmed in 67% of patients. PTEN mutations identified in 48.3% of cases, primarily affecting chromosome 10 (10q23.3). Progression-free survival was experienced by 74% of patients and reoperation for progression needed in 3.5% of cases. DCG is a rare tumor associated with PTEN mutations. MRI aids in diagnosis and surgery ensures favorable outcomes. Standardized genetic screening and targeted therapies require further study, as they hold promise for refining diagnosis and long-term management.
Atypical presentations and neurosurgical Synergy in the treatment of paravertebral tumors in children: Lessons from a single institution.
This study aims to evaluate the surgical management and outcomes of pediatric paravertebral tumors, particularly focusing on dumbbell tumors, within a single medical center. Employing a retrospective analysis at Taichung Veterans General Hospital from January 2016 to February 2022, we included pediatric patients diagnosed with paravertebral tumors confirmed via MRI and histopathology, who underwent surgical treatment. We aimed to assess the extent of tumor resection as the primary outcome, with postoperative complications, recurrence rates, and neurological function as secondary outcomes, utilizing descriptive statistics. In the given period, four pediatric patients, two males and two females aged 53-204 months, were treated at our institute for paravertebral tumors using CT and MRI for diagnosis. The tumors were located in the posterior mediastinum (3 patients) and retroperitoneum (1 patient), with varied MRI findings. Diagnoses included Ganglioneuroma, Schwannoma, Plexiform neurofibroma, and Spindle cell sarcoma. Treatments involved minimally invasive surgeries, with three cases using intraoperative neurological monitoring. Despite a mean operative time of 376 min and a 13-day average hospital stay, one patient experienced recurrence requiring chemotherapy, another had distant metastasis, and one died at a two-year median follow-up. Our study concludes that CT and MRI are crucial for diagnosing paravertebral tumors and planning surgery, and a multidisciplinary approach is essential for optimal functional preservation in pediatric patients. These findings emphasize the necessity for ongoing research to refine treatment strategies and improve patient outcomes in this complex clinical area.
A case of colon Ganglioneuroma resembling an inverted diverticulum on endoscopy.
Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma.
Telomere maintenance mechanisms (TMM) have garnered attention as a mechanism associated with the treatment resistance and poor prognosis of neuroblastoma (NB). Ganglioneuroblastoma (GNB) and ganglioneuroma (GN) are histologically classified as neuroblastic tumors (NTs) along with NB; however, few reports have addressed TMM in GNB and GN. The present study analyzed 321 NTs diagnosed in Japan, including 255 NB cases, 48 GNB cases and 18 GN cases, using a quantitative PCR-based C-circle assay for alternative lengthening of telomeres (ALT) and a telomerase reverse transcriptase (TERT) mRNA expression assay. ALT was identified in 38 NB cases (38/255, 15%) and 6 GNB cases (6/48, 12.5%), but not in GN. High TERT expression was observed in 38% (64/169), 23% (7/31) and 14% (1/7) of NB, GNB and GN cases, respectively. TMM activation, defined as ALT(+) and/or high TERT expression, occurred in 12/48 GNB cases and 1/18 GN cases, particularly in the GNB-nodular type (10/21, 48%), which was similar to 39% (100/255) of NB cases. Furthermore, TMM(+) GNBs exhibited distinct features, including a high frequency of ATRX alterations and a lower frequency of TERT rearrangements. Chromosomal aberration analysis revealed frequent 7q gain, 17q gain and 11q loss in ALT(+) NTs (83%). Overall, TMM serves as a poor prognostic marker for high-risk NB and offers valuable insights for the risk classification of GNBs.
Publicações recentes
A rare case of retroperitoneal ganglioneuroma in adult: diagnostic and management challenges.
A giant cervical ganglioneuroma in a middle-aged man: a case report.
Not all that wheezes is asthma: A pediatric posterior mediastinal ganglioneuroma mimicking recurrent asthma.
Ganglioneuroma in a Meller's chameleon (Triocerosmelleri).
Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma.
📚 EuropePMC1.208 artigos no totalmostrando 200
Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma.
Oncology lettersCavitary Pulmonary Blastomycosis and an Incidental Retroperitoneal Ganglioneuroma Mimicking Metastatic Disease.
Cureus[Correlation study between tumor location and pathological subtypes of neuroblastic tumors associated with opsoclonus myoclonus ataxia syndrome].
Zhonghua er ke za zhi = Chinese journal of pediatricsStereotactic Body Radiation Therapy in the Management of Recurrent Unresectable Retroperitoneal Ganglioneuroma.
CureusAn Unexpected Diagnosis After a Viral Infection: A Case of a Giant Mediastinal Ganglioneuroma.
CureusBilateral pheochromocytoma as a late presentation of neurofibromatosis type 1.
Endocrinology, diabetes & metabolism case reportsCan indocyanine green fluorescence aid operative decision making in neuroblastic tumour surgery? Early experience from a single centre.
Journal of pediatric surgeryA case of colon Ganglioneuroma resembling an inverted diverticulum on endoscopy.
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the LiverTotal laparoscopic excision of pelvic retroperitoneal ganglioneuroma: a case report and review of the literature.
Frontiers in surgeryMixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients.
Acta neuropathologica communicationsPathology of peripheral neuroblastic tumors.
Diagnostic pathologyAdrenal schwannomas and adrenal ganglioneuromas: our experience and CT characteristic-focused systematic review.
EndocrineGanglioneuroma has a potential for lymph node metastasis, not impacting recurrence.
Frontiers in oncologySerum steroid profiling by LC-MS/MS in distinguishing adrenocortical carcinoma from other indeterminate adrenal masses.
The Journal of steroid biochemistry and molecular biologyResection of bilateral dumbbell C2 ganglioneuroma.
Journal of spine surgery (Hong Kong)A case of giant retroperitoneal ganglioneuroma encasing major vascular structures.
Journal of surgical case reportsCavernous ganglioneuroma of the thoracic spine: surgical nuances and outcomes following limited anterior resection.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research SocietyCopy-Number Aberrations in Circulating Tumor DNA Enable Diagnosis and Risk Stratification of Pediatric Neuroblastic Tumors.
Cancer research communications[Clinicopathological and molecular genetic features of pediatric malignant peripheral nerve sheath tumors originating from ganglioneuroma/ganglioneuroblastoma].
Zhonghua bing li xue za zhi = Chinese journal of pathologyMultiple Endocrine Neoplasia Type 5 due to Germline MAX Mutations: A Systematic Review of Tumor Spectrum and Clinical Features.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsMixed gangliocytoma-silent somatotroph pituitary adenoma: a rare variant with pregnancy-associated growth.
BMJ case reportsNon-Syndromic Ganglioneuromatosis of the Gallbladder, an Extremely Rare Condition: Case Report and Literature Review.
Reports (MDPI)A potentially dangerous case of mistaken identity: giant asymptomatic composite phaeochromocytoma.
Endocrinology, diabetes & metabolism case reports18F-FDG PET/CT manifestations of extra-adrenal retroperitoneal ganglioneuroma: a retrospective study of 21 cases.
Annals of nuclear medicineSurgical management of a giant retrorectal ganglioneuroma via an open anterior approach: a case report.
Annals of medicine and surgery (2012)Retroperitoneal and pelvic schwannoma/neurofibroma resection: surgical strategies and outcomes in a neurosurgical cohort.
Acta neurochirurgicaAdult retroperitoneal Ganglioneuroma: Case report of an incidental mass treated with robotic excision.
Urology case reportsPreoperative differentiation of retroperitoneal ganglioneuroma and schwannoma using an ultrasonography-based multivariable model and simplified score: development and single-center internal validation.
Frontiers in surgery[Ganglioneuroma of the Small Intestine Mimicking Crohn's Disease].
Acta gastroenterologica LatinoamericanaDumbbell ganglioneuroma of the lumbar spine: a case report and literature review.
Frontiers in surgeryAtypical Polypoid Ganglioneuroma Initially Detected by Ultrasonography With Signs of Intussusception: A Case Report.
Journal of clinical ultrasound : JCUClinical features and oncologic outcomes of primary retroperitoneal ganglioneuroma: a retrospective cohort study of 51 patients from a high-volume sarcoma center.
Frontiers in surgeryHistologic Response to Induction Chemotherapy in High-Risk Neuroblastoma.
Cancer medicineThe Advancing Frontier: Robotic-Assisted Laparoscopy in Pediatric Tumor Management.
Indian journal of surgical oncologyColonic Ganglioneuroma-A Rare Finding During Colonoscopy.
Diagnostics (Basel, Switzerland)Multivisceral Resection for Suspected Adrenocortical Carcinoma.
Journal of clinical medicineDysplastic cerebellar gangliocytoma: a six-decade study.
Journal of neurosurgical sciences[Adrenal ganglioneuroma].
Arkhiv patologiiGiant retroperitoneal ganglioneuroma with lumbar nerve root involvement in a child: a case report and a systematic review of literature.
European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research SocietyLaparoscopic management of multiple retroperitoneal ganglioneuromas with 5-year follow-up: a case report.
BMC urologyEnd-to-end deep learning model for the diagnosis and segmentation of primary retroperitoneal neoplasm: a multicenter cohort study.
EClinicalMedicineNew heights in CT differentiation of adrenal lesions and a rational definition of non-enhancement.
BMC medical imaging3D Model-Guided Robot-Assisted Giant Presacral Ganglioneuroma Exeresis by a Uro-Neurosurgeons Team: A Case Report.
Reports (MDPI)Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures.
Open medicine (Warsaw, Poland)Left robotic assisted thoracic surgery (RATS) stellate ganglion ganglioneuroma resection with post-operative Harlequin syndrome.
Multimedia manual of cardiothoracic surgery : MMCTSResection of a ganglioneuroma encasing major blood vessels using three-dimensional laparoscopy combined with organ suspension: A case report.
World journal of gastrointestinal surgeryA Rare Case: Composite Paraganglioma-Ganglioneuroma in a Neurofibromatosis 1 Patient and Literature Review.
Neuro endocrinology lettersParapharyngeal Space Ganglioneuroma in a Child: A Report of a Rare Case.
CureusClinical features and surgical treatment of mediastinal masses in children: a retrospective study of 51 cases.
Frontiers in pediatricsComplete resection of an incidentally discovered posterior mediastinal ganglioneuroma in an asymptomatic child: a case report.
Journal of surgical case reportsUnveiling Adrenal Ganglioneuroma in a 6-Year-Old Boy: Imaging Insights and Minimally Invasive Treatment.
Journal of clinical ultrasound : JCUSurprise Diagnosis of a Lumbar Mass: Cytological Diagnosis of Retroperitoneal Ganglioneuroma in a Rare Presentation.
Diagnostic cytopathologyRare Presentation of Cervical Ganglioneuroma: A Case Report.
CureusSubcostal approach using the single-port robotic system for a giant ganglioneuroma in a child.
JTCVS techniquesAdrenal ganglioneuroma: two case reports and literature review.
Frontiers in oncologyComparative analysis of growth hormone-secreting mixed gangliocytomas and pure growth hormone pituitary adenomas.
Clinical neurology and neurosurgeryComposite gangliocytoma/neuroma and neuroendocrine tumour: a contemporary analysis of 71 cases shows risk factors for metastasis.
HistopathologyPredictive model based on blood cell analysis and coagulation function indicators for neuroblastic tumors staging diagnosis.
Frontiers in oncologyGenetic evaluation of five patients with ROHHAD-NET using whole genome sequencing and optical genome mapping.
Orphanet journal of rare diseasesAdrenal Incidentaloma Masquerading as Malignancy: A Rare Case of Ganglioneuroma with Nodal Metastasis.
Case reports in oncologyDysplastic gangliocytoma of the cerebellum with an unusual radiological finding.
Ceskoslovenska patologieGanglioneuroma: a rare disease that simulates malignancy.
Medicina clinicaCase Report: Malignant transformation of ganglioneuroma in the rectovaginal septum to malignant peripheral nerve sheath tumor based on neurofibromas.
Frontiers in oncologyA rare presentation of a sacral mass: Ganglioneuroma.
Radiology case reportsAtypical presentations and neurosurgical Synergy in the treatment of paravertebral tumors in children: Lessons from a single institution.
Pediatrics and neonatologyThe clinical spectrum of adrenal ganglioneuromas extends from severe hypertension to an asymptomatic incidentaloma; two cases and mini review of literature.
Hormones (Athens, Greece)Diagnostic Challenges and Updates in Peripheral Neuroblastic Tumors.
Surgical pathology clinicsTransperitoneal Laparoscopic Adrenalectomy in Children - Initial Experience in an Emerging Tertiary Center in Eastern India.
Journal of Indian Association of Pediatric SurgeonsAdrenal Ganglioneuroma Masquerading as a Suspicious Adrenal Incidentaloma: A Case Report and Review of the Literature.
CureusSS18::POU5F1-fused sarcoma of the parotid with divergent ganglioneuromatous differentiation-a novel manifestation of a rare tumor.
Virchows Archiv : an international journal of pathologyPrecision en-bloc retroperitoneal paraganglioma resection performed laparoscopically: A case report.
World journal of clinical casesTertiary Lymphoid Structures Are Associated with Progression-Free Survival of Peripheral Neuroblastic Tumor Patients.
CancersRare Adrenal Tumors and Adrenal Metastasis.
The Urologic clinics of North AmericaAn Exophytic Pancreatic Mass Diagnosed as Ganglioneuroma.
ACG case reports journalA rare case of a composite phaeochromocytoma-ganglioneuroma in Australia.
Journal of surgical case reportsSynchronous Ipsilateral Adrenal and Retroperitoneal Ganglioneuroma: A Unique Case of Large Tumor Mass.
Case reports in medicineStereotactic radiosurgery for brain metastases secondary to adrenal ganglioneuroblastoma: illustrative case.
Journal of neurosurgery. Case lessonsNeural or Neural-Related Colorectal Lesion Incidence Varies by Site, and Multifocal Cases Are Often Syndromic: Insights From a Series of 593 Patients.
Archives of pathology & laboratory medicineComposite Pheochromocytoma-Paraganglioma With Ganglioneuroma: A Dual-Center Clinical Experience.
Journal of the Endocrine SocietyComposite Ganglioneuroma and Schwannoma of the Cervical Sympathetic Chain: A Case Report.
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India[Retroperitoneal Ganglioneuroma with Multifocal Bone Involvement in a Middle-Aged Woman].
Hinyokika kiyo. Acta urologica JaponicaProteomic analysis reveals chromatin remodeling as a potential therapeutical target in neuroblastoma.
Journal of translational medicineRetroperitoneal ganglioneuroma simulating lymphoma: An unusual case presentation.
Radiology case reportsAdrenocorticotropin-Secreting Pure Adrenal Ganglioneuroma Leading to Cushing Syndrome.
JCEM case reportsLaparoscopic resection of neurogenic presacral tumors.
Zhurnal voprosy neirokhirurgii imeni N. N. BurdenkoTwo Cases of Composite Pheochromocytoma-Ganglioneuromas With Plasma Metanephrine Levels in the Subclinical Range Pheochromocytoma-Ganglioneuroma.
AACE clinical case reportsA rare case of lipomatous ganglioneuroma of the adrenal gland.
Urology case reportsA Single-Institution Analysis of Surveillance Practice for Low-Risk Neuroblastic Tumors.
The Journal of surgical researchMature Adrenal Ganglioneuroma With Lipomatous Content: A Radiological and Histopathological Diagnostic Challenge.
CureusAdvances in multimodal imaging for adrenal gland disorders: integrating CT, MRI, and nuclear medicine.
Japanese journal of radiologyAdolescent thoracic scoliosis due to giant ganglioneuroma: a two-case report and literature review.
Nagoya journal of medical science[Adrenal tumors in pediatric patients treated with minimally invasive surgery].
Andes pediatrica : revista Chilena de pediatriaAmpullary composite gangliocytoma/neuroma and neuroendocrine tumor management.
Endocrine-related cancerROHHAD NET in Retrospect: Key Lessons Learned from Five Cases.
Indian journal of pediatricsArterio-Ureteral Fistula as a Long-term Complication Following Retroperitoneal Presacral Ganglioneuroma Resection: Case Report in an Adolescent and Review of the Literature.
European journal of pediatric surgery reportsAn intracranial odyssey: pediatric ganglioneuroma arising from the trigeminal ganglion: a case report and review of the literature.
Journal of medical case reportsGanglioneuroma: a rare appendiceal tumour - case report and literature review.
Journal of surgical case reportsAsymptomatic retroperitoneal ganglioneuroma adjacent to the abdominal organs and large abdominal vessels.
Polish archives of internal medicineDysplastic ganglion cell tumor of the right cerebellum: A case report and literature review.
MedicineCombined Ganglioneuroma-Schwannoma of the Retroperitoneum: An Exceedingly Rare Hybrid Nerve Sheath-Ganglioneural Tumor.
International journal of surgical pathologyToe Walking Secondary to Tethered Spinal Cord Caused by Ganglioneuroma: A Case Report.
CureusCharacterisation of Paediatric Neuroblastic Tumours by Quantitative Structural and Diffusion-Weighted MRI.
Journal of clinical medicineManagement of Ganglioneuroma and Ganglioneuroblastoma Intermixed: A United Kingdom Children's Cancer and Leukaemia Group (UK CCLG) Nationwide Study Report.
Pediatric blood & cancerPathologists' integration of prior biopsies of women with germline PTEN mutations may expedite the identification of this rare cancer predisposition syndrome.
PathologyCervical Ganglio-neuroma, a Rare Neck Mass in Pediatric Age: A Case Report.
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of IndiaMixed Gangliocytoma-Pituitary Adenoma: A Systematic Review of Diagnostic Features, Clinical Management, and Surgical Outcomes.
World neurosurgeryGiant ganglioneuroma of the mediastinum: a case report.
Frontiers in oncologyGanglioneuroma in Head and Neck: A Case Report of a Laryngeal Ganglioneuroma and a Systematic Review of the Literature.
CancersUnraveling the glycosphingolipid metabolism by leveraging transcriptome-weighted network analysis on neuroblastic tumors.
Cancer & metabolismSolitary Colonic Ganglioneuroma With Central Depression: A Rare Case With Unique Morphology.
The American journal of gastroenterologyAdrenal Ganglioneuroma With Radiology-Pathology Correlation.
CureusAdrenal ganglioneuroma with retroperitoneal lymph node metastasis: A rare scenario.
Journal of cancer research and therapeuticsGanglioneuroma of the cervical sympathetic chain: A case report and review of literature.
Radiology case reportsAn extremely rare case of presacral ganglioneuroma in a young male with lower back pain: First case report from Iraq.
Radiology case reportsCase Report: Adrenal schwannoma associated with ganglioneuroma.
Frontiers in surgeryVasoactive Intestinal Peptide-Producing Neuroblastic Tumors: A Rare Cause of Refractory Diarrhea.
CureusBilateral choroidal ganglioneuroma: a comprehensive analysis of vision decline in a 6-year-old boy.
International journal of ophthalmologyAdrenal ganglioneuroma with nodal metastases on 123I-MIBG SPECT/CT and 18F-FDG PET/CT.
Radiology case reportsInvasive trigeminal ganglioneuroma: A case report and review of the literature.
Acta radiologica openSpinal ganglioneuroma: a rare and challenging tumor in the pediatric population.
Child's nervous system : ChNS : official journal of the International Society for Pediatric NeurosurgeryLaparoscopic resection for retroperitoneum ganglioneuroma with Supine hypotension syndrome.
Surgical case reportsParavertebral Ganglioneuroma in Pediatric Age: A Case Report.
CureusCase report: Treatment response of NF-1-associated bladder ganglioneuroma to trametinib.
Frontiers in oncologyGiant mediastinal ganglioneuroma in adolescents.
Asian journal of surgeryTwo rare cases of giant ganglioneuroma of the posterior mediastinum in overweight children.
Asian journal of surgeryEsophageal ganglioneuromatosis; a rare cause of intractable esophageal stenosis: a case report.
BMC pediatricsGanglioneuromatous polyposis associated with type 2 B multiple endocrine neoplasia (MEN 2B) - case report.
Annals of agricultural and environmental medicine : AAEMSuccessful endoscopic approach for peripheral neuroblastic tumors in children.
Pediatrics international : official journal of the Japan Pediatric SocietyMixed pituitary adenoma/pituitary neuroendocrine tumor-gangliocytoma: Immunohistochemical insights.
Journal of neuropathology and experimental neurologyExpression of GD2 and GD3 in peripheral neuroblastic tumors.
Indian journal of pathology & microbiologyA head-to-head comparison of computed tomography- and magnetic resonance imaging-based radiomics in assessing pediatric peripheral neuroblastic tumor cell behavior.
Abdominal radiology (New York)Giant Ganglioneuroma of the Lumbar Spine: A Rare Cause of Radiculopathy.
Case reports in surgeryCervical ganglioneuroma as a rare cause of cervicogenic headache: A case report and literature review.
Journal of back and musculoskeletal rehabilitationRare adrenal incidentaloma: ganglioneuroma.
Journal of surgical case reportsRobotic thoracic surgery for neurogenic tumors.
Journal of neurosurgeryLarge retroperitoneal ganglioneuroma revealed by a left ovarian endometrioma: A case report.
SAGE open medical case reportsSpinal ganglioneuroma with extension to the brachial plexus. The challenges for total surgical excision, a case report.
International journal of surgery case reportsMultiple endocrine neoplasia type 2B diagnosed after small intestinal volvulus with progressive megacolon in an adolescent.
Clinical journal of gastroenterologyMassive Silent abdominal ganglioneuroma in the setting of non-Hodgkin lymphoma : A rare case report.
International journal of surgery case reportsA novel method of tunneling retroperitoneoscopic adrenalectomy: a prospective study.
BMC urology[Intraspinal composite gangliocytoma/neuroma and neuroendocrine tumor with vascular malformation: report of a case].
Zhonghua bing li xue za zhi = Chinese journal of pathologyCombined unilateral biportal endoscopy and video-assisted thoracoscopic surgery for complete excision of a T3-T4 right ganglioneuroma.
Neurosurgical focus: VideoA Preliminary Study on the Application of Contrast-Enhanced Ultrasonography in Children With Peripheral Neuroblastic Tumors.
Ultrasound in medicine & biologySolitary Ganglioneuromatous Hamartoma Tongue in a Newborn - A Rare Entity.
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of IndiaLaryngeal Ganglioneuromatosis in a Child With Multiple Endocrine Neoplasia Type 2B (MEN2B): Case Report and Review of Literature.
CureusA Woman with Bilateral Pheochromocytoma and Tuberous Sclerosis Complex.
AACE clinical case reportsNeuroganglioma in the posterior mediastinum: an incidental discovery.
Journal of surgical case reportsClinical features and treatment options for pediatric adrenal incidentalomas: a retrospective single center study.
BMC pediatricsDouble-balloon enteroscopy for the detection of GIST in a patient with type 1 neurofibromatosis.
Revista espanola de enfermedades digestivas[Surgically Resected Cases of Mediastinal Ganglioneuroma Detected in Adults].
Kyobu geka. The Japanese journal of thoracic surgeryCervical Ganglioneuroma Associated With Neurofibromatosis Type 1.
The Journal of craniofacial surgeryRobotic excision of a retrocaval ancient schwannoma: a case report.
Journal of surgical case reportsGanglioneuroma of the Cervical Sympathetic Chain - A Rare Occurrence.
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of IndiaBenign paraspinal ganglioneuroma with paraneoplastic opsoclonus myoclonus syndrome.
BMJ case reportsA case of thoracic intraspinal ganglioneuroma with intermittent fever as the main symptom.
Asian journal of surgeryRetroperitoneal Peripancreatic Ganglioneuroma Encasing the Celiac Trunk and Superior Mesenteric Artery.
CureusAppendiceal ganglioneuroma incidentally found during resection of recurrent rectal cancer: case report and review of the literature.
Journal of surgical case reports[Intestinal ganglioneuromatosis as an early extra-endocrine manifestation of type 2B multiple endocrine neoplasia].
Problemy endokrinologiiAnti-metabolic glutamate receptor 5 encephalitis with gangliocytoma: a case and review of the literature.
BMC neurologyRobotic-assisted surgery for gynecological indications in children and adolescents: European multicenter report.
Journal of robotic surgeryA case report of multimodal ultrasound imaging in the diagnosis of giant retroperitoneal ganglioneuroma.
Cancer innovationSynchronous ipsilateral adrenal cortical adenoma and ganglioneuroma: A case report.
Indian journal of urology : IJU : journal of the Urological Society of IndiaDiagnostic imaging of a rare case of incidental adrenal ganglioneuroma.
Acta bio-medica : Atenei ParmensisGanglioneuroma presents as the absence of sweating on the face and the opposite trunk in a child.
Pediatric pulmonologyN6-methyladenosine-mediated overexpression of long noncoding RNA ADAMTS9-AS2 triggers neuroblastoma differentiation via regulating LIN28B/let-7/MYCN signaling.
JCI insightColorectal Ganglioneuromas Associated with Cowden Syndrome.
Internal medicine (Tokyo, Japan)Epidemiological and clinical characteristics of children with peripheral neuroblastic tumors: a study on a Moroccan population.
Journal of cancer research and clinical oncologyComposite paraganglioma-ganglioneuroma with atypical catecholamine profile and phenylethanolamine N-methyltransferase expression: a case report and literature review.
Endocrine journalLate Relapse in Neuroblastoma: Case Report and Review of the Literature.
Current pediatric reviewsA not so incidental 'incidentaloma' - pediatric ganglioneuroma-associated cerebellar degeneration and super-refractory status epilepticus: case report and literature review.
Frontiers in neurologyLocalized Multifocal Retroperitoneal Ganglioneuroma with an Infiltrative Appearance on Imaging: A Case Report.
Case reports in oncologyA rare entity: Ganglioneuroma of the prostate.
Urology case reportsLaparoscopic Transperitoneal Adrenalectomy for Adrenal Tumors in Children: Technical Considerations and Surgical Experience.
Journal of laparoendoscopic & advanced surgical techniques. Part AGanglioneuromas in Childhood: Hacettepe Experience With 70 Cases.
Journal of pediatric surgeryMusashi-2 (MSI2) promotes neuroblastoma tumorigenesis through targeting MYC-mediated glucose-6-phosphate dehydrogenase (G6PD) transcriptional activation.
Medical oncology (Northwood, London, England)Preoperative differentiation of mediastinum and retroperitoneum ganglioneuroma from schwannoma with clinical data and enhanced CT: developing a multivariable prediction model.
Clinical radiologyLaparoscopic resection of ganglioneuroma from the hepatoduodenal ligament: A case report.
International journal of surgery case reports[Peripheral neuroblastic tumors in childhood].
Pathologie (Heidelberg, Germany)A Sizeable Adrenal Ganglioneuroma: A Case Report.
CureusA case report on POEMS syndrome with high parathyroid hormone and repeated surgery, a rare presentation of a rare disease.
International journal of surgery case reportsSingle-cell transcriptome sequencing reveals tumor heterogeneity in family neuroblastoma.
Frontiers in immunologyComputer-assisted resection of multifocal primary neuroblastic tumors: A case report.
Asian journal of surgeryNonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed-Case Report and Literature Review.
Journal of clinical medicineOperative challenges in a gigantic ganglioneuroma of the posterior mediastinum with mediastinal compression.
Journal of surgical case reportsOverreliance on Radiological Findings Leading to Misdiagnosed Giant Retroperitoneal Ganglioneuroma: A Case Report and Literature Review.
CureusRetroperitoneal ganglioneuroma: A five-case series from a single Tunisian center.
International journal of surgery case reportsCoexistence of a small bowel gastrointestinal stromal tumor, small bowel adenocarcinoma and ganglioneuroma in a patient with neurofibromatosis type I caused intussusception.
Revista espanola de enfermedades digestivasMaturation of metastases in peripheral neuroblastic tumors (neuroblastoma) of children.
Journal of neuropathology and experimental neurologyComposite pheochromocytoma associated with neurofibromatosis type 1.
IJU case reportsNeck Ganglioneuroma Mimicking a Thyroid Nodule in a Four-Year-Old Child: A Case Report and Review of the Literature.
International journal of endocrinology and metabolismEn Bloc Resection of a Giant Ganglioneuroma of the Chest Through Clamshell Thoracotomy.
World journal for pediatric & congenital heart surgerySpinal Ganglioneuroma: A Systematic Review of the Literature.
World neurosurgeryNeuropil-like islands are a possible pathogenetic link between glioblastoma and gangliocytoma/ganglioglioma in a case of synchronous bilateral brain tumors.
Neuropathology : official journal of the Japanese Society of NeuropathologyIntraparotid Ganglioneuroma: A rare case report.
Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of IndiaGanglioneuroma presenting as subpulmonic effusion-a differential to consider?
Indian journal of thoracic and cardiovascular surgeryImage-defined risk factors in localized thoracic neuroblastoma and ganglioneuroma.
Pediatric blood & cancerAdrenal ganglioneuroma: Features and outcomes of cases series.
Asian journal of surgeryImaging of Ganglioneuroma: A Literature Review and a Rare Case of Cystic Presentation in an Adolescent Girl.
Diagnostics (Basel, Switzerland)Diagnosis of PTEN mosaicism: the relevance of additional tumor DNA sequencing. A case report and review of the literature.
BMC medical genomicsClinical Characteristics and Long-Term Outcomes of Adrenal Tumors in Children and Adolescents.
Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes AssociationAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- [Correlation study between tumor location and pathological subtypes of neuroblastic tumors associated with opsoclonus myoclonus ataxia syndrome].
- Dysplastic cerebellar gangliocytoma: a six-decade study.
- Atypical presentations and neurosurgical Synergy in the treatment of paravertebral tumors in children: Lessons from a single institution.
- A case of colon Ganglioneuroma resembling an inverted diverticulum on endoscopy.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver· 2026· PMID 41692647mais citado
- Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma.
- A rare case of retroperitoneal ganglioneuroma in adult: diagnostic and management challenges.
- A giant cervical ganglioneuroma in a middle-aged man: a case report.
- Not all that wheezes is asthma: A pediatric posterior mediastinal ganglioneuroma mimicking recurrent asthma.
- Ganglioneuroma in a Meller's chameleon (Triocerosmelleri).
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:251992(Orphanet)
- MONDO:0005033(MONDO)
- GARD:20731(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q1124606(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
