Raras
Buscar doenças, sintomas, genes...
Ganglioneuroma
ORPHA:251992CID-10 · D36.1CID-11 · 2A00.21DOENÇA RARA

Tumor neuroblástico benigno do sistema nervoso simpático que ocorre na infância. O ganglioneuroma normalmente surge do tronco simpático no mediastino. As características histológicas incluem proliferação de células fusiformes (semelhante a um neurofibroma) e a presença de grandes células ganglionares. As características comuns incluem massa abdominal palpável, hepatomegalia e massa torácica detectada na radiografia de tórax de rotina.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

Tumor neuroblástico benigno do sistema nervoso simpático que ocorre na infância. O ganglioneuroma normalmente surge do tronco simpático no mediastino. As características histológicas incluem proliferação de células fusiformes (semelhante a um neurofibroma) e a presença de grandes células ganglionares. As características comuns incluem massa abdominal palpável, hepatomegalia e massa torácica detectada na radiografia de tórax de rotina.

Pesquisas ativas
5 ensaios
12 total registrados no ClinicalTrials.gov
Publicações científicas
2.077 artigos
Último publicado: 2026 Apr
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: D36.1
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫃
Digestivo
4 sintomas
🦴
Ossos e articulações
3 sintomas
🧠
Neurológico
2 sintomas
🫘
Rins
2 sintomas

+ 5 sintomas em outras categorias

Características mais comuns

100%prev.
Ganglioneuroma
55%prev.
Neurofibromatose intestinal múltipla
Frequente (79-30%)
55%prev.
Anormalidade das glândulas adrenais
Frequente (79-30%)
55%prev.
Polipose colorretal
Frequente (79-30%)
55%prev.
Morfologia anormal do mediastino
Frequente (79-30%)
17%prev.
Neoplasia da glândula adrenal
Ocasional (29-5%)
16sintomas
Muito frequente (1)
Frequente (4)
Ocasional (5)
Muito raro (6)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 16 características clínicas mais associadas, ordenadas por frequência.

Ganglioneuroma
Muito frequente100%
Neurofibromatose intestinal múltiplaMultiple intestinal neurofibromatosis
Frequente (79-30%)55%
Anormalidade das glândulas adrenaisAbnormality of the adrenal glands
Frequente (79-30%)55%
Polipose colorretalColorectal polyposis
Frequente (79-30%)55%
Morfologia anormal do mediastinoAbnormality of the mediastinum
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico2.077PubMed
Últimos 10 anos200publicações
Pico202578 papers
Linha do tempo
2026Hoje · 2026🧪 2013Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

1 gene identificado com associação a esta condição.

ALKALK tyrosine kinase receptorMajor susceptibility factor inRestrito
FUNÇÃO

Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system (PubMed:11121404, PubMed:11387242, PubMed:16317043, PubMed:17274988, PubMed:30061385, PubMed:34646012, PubMed:34819673). Also acts as a key thinness protein involved in the resistance to weight gain: in hypothalamic neurons, controls energy expenditure acting as a nega

LOCALIZAÇÃO

Cell membrane

VIAS BIOLÓGICAS (2)
Signaling by ALKMDK and PTN in ALK signaling
OUTRAS DOENÇAS (9)
large congenital melanocytic nevusneuroblastomaganglioneuroblastomadifferentiated thyroid carcinoma
HGNC:427UniProt:Q9UM73

Variantes genéticas (ClinVar)

4,870 variantes patogênicas registradas no ClinVar.

🧬 ALK: NM_004304.5(ALK):c.793G>A (p.Glu265Lys) ()
🧬 ALK: NM_004304.5(ALK):c.1546+18C>T ()
🧬 ALK: NM_004304.5(ALK):c.2752_2754del (p.Arg918del) ()
🧬 ALK: NM_004304.5(ALK):c.1912+10C>A ()
🧬 ALK: NM_004304.5(ALK):c.595G>C (p.Gly199Arg) ()
Ver todas no ClinVar

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
1Fase 12
·Pré-clínico4
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 6 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Ganglioneuroma

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

3 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

12 ensaios clínicos encontrados, 5 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
644 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 644

#1

[Correlation study between tumor location and pathological subtypes of neuroblastic tumors associated with opsoclonus myoclonus ataxia syndrome].

Zhonghua er ke za zhi = Chinese journal of pediatrics2026 Mar 14

Objective: To analyze the correlation between the location and pathological subtypes of of neuroblastic tumors (NBT) associated with opsoclonus myoclonus ataxia syndrome (OMAS). Methods: A case-control study. Clinical data of 34 pediatric patients diagnosed with NBT complicated by OMAS (NBT-OMAS group), who were hospitalized in the Department of Pediatrics, Peking University First Hospital from January 2007 and December 2022 were collected retrospectively. The control group consisted of 34 age and sex-matched patients with NBT only (NBT-only group) admitted during the same period. Chi-square test or Fisher exact test was used to compare the distribution of tumor locations and pathological subtypes between the two groups. Cramer's V coefficient was applied to analyze the correlation between them. The outcomes of the patients were followed up. Results: The age of patients in the NBT-OMAS group was 18 (12, 28) months, while that of the NBT-only group was 20 (13, 31) months. In the NBT-OMAS group, 28 cases (82%) had tumors located in the paraspinal sympathetic chain and 6 cases (18%) in the adrenal glands. In the NBT-only group, 6 cases (18%) had tumors located in the adrenal glands and 28 cases (82%) in the paraspinal sympathetic chain, with a statistically significant difference between the two groups (χ2=10.69, P<0.01). The distribution of pathological subtypes of tumors in the NBT-OMAS group was as follows: 20 cases (59%) of ganglioneuroblastoma (GNB), 10 cases (29%) of neuroblastoma (NB), 4 cases (12%) of ganglioneuroma (GN). In the NBT-only group, NB was predominant with 21 cases (62%), GNB in 13 cases (38%), and no GN subtype was observed. There was a statistically significant difference between the two groups (χ2=8.59, P<0.01). In the NBT-OMAS group, the pathological subtype of tumors located in the adrenal gland was mainly NB, with 5 cases (5/6). For tumors located paravertebral to the thoracic and lumbar spine, the predominant subtype was GNB, with 8 cases (8/11) and 11 cases (11/13) respectively. As for tumors paravertebral to the sacral spine, the major subtype was NB, with 3 cases (3/4). In the NBT-only group, NB was the pathological subtype in 18 cases of adrenal gland tumors (18/19). For tumors paravertebral to the cervical spine, NB and GNB each accounted for 2 cases respectively (2/4). Tumors located paravertebral to the thoracic spine and paravertebral to the lumbar spine were all GNB for 5 cases (5/5), while those paravertebral to the sacral spine were all NB for 1 case (1/1). The Cramer's V coefficients of the tumor location and pathological subtype in the two groups were 0.65 and 0.81, respectively. The follow-up ended on December 31, 2023. In the NBT-OMAS group, 1 case had tumor recurrence and 1 case died due to tumor progression; both the recurrent and fatal tumors were located in the adrenal glands with the pathological subtype of NB. In the NBT-only group, 11 cases died of tumor progression, among which 8 cases had primary tumor located in the adrenal gland and with the pathological subtype of NB. Conclusions: In children with NBT-OMAS, tumors located in the paravertebral sympathetic chains are significantly more common than those in the adrenal gland, the pathological subtype of tumors was predominantly GNB. The tumor location was correlated with its pathological subtype. 目的: 分析并发眼阵挛肌阵挛共济失调综合征(OMAS)的神经母细胞肿瘤(NBT)肿瘤发生部位与病理亚型的相关性。 方法: 病例对照研究。收集2007年1月至2022年12月在北京大学第一医院儿科住院且明确诊断为NBT并发OMAS的34例患儿(NBT-OMAS组)临床资料,对照组为同期入院、年龄和性别都匹配的单纯NBT患儿34例(单纯NBT组),采用χ2 检验或Fisher确切概率法比较两组肿瘤发生部位、病理亚型的分布情况,通过Cramer′s V系数比较两者的相关性,随访患儿结局。 结果: NBT-OMAS组患儿年龄18(12,28)月龄,单纯NBT组年龄为20(13,31)月龄。NBT-OMAS组肿瘤发生于脊柱旁交感神经链者28例(82%)、肾上腺者6例(18%);单纯NBT组中发生于肾上腺和脊柱旁交感神经链者分别为19例(56%)和15例(44%),两组比较差异有统计学意义(χ2=10.69,P<0.01)。NBT-OMAS组肿瘤病理亚型分布为节细胞神经母细胞瘤(GNB)20例(59%),神经母细胞瘤(NB)10例(29%),节细胞神经瘤(GN)4例(12%);单纯NBT组病理类型主要为NB 21例(62%),GNB 13例(38%),无GN亚型,两组比较差异有统计学意义(χ2=8.59,P<0.01)。NBT-OMAS组中,6例肿瘤位于肾上腺者中5例为NB;11例位于胸椎旁者中8例为GNB;13例位于腰椎旁者中11例为GNB;4例位于骶椎旁者中3例为NB。单纯NBT组中,19例肿瘤位于肾上腺中18例为NB;4例位于颈椎旁者中NB和GNB各占2例;5例位于胸椎旁和5例位于腰椎旁者均为GNB;1例位于骶椎旁者为NB。两组肿瘤所在部位与其病理亚型的Cramer′s V系数分别为0.65、0.81。随访截至2023年12月31日,NBT-OMAS组1例肿瘤复发、1例因肿瘤进展死亡,肿瘤均位于肾上腺且病理亚型为NB;单纯NBT组有11例因肿瘤进展死亡,其中8例原发肿瘤位于肾上腺且病理亚型为NB。 结论: NBT-OMAS患儿肿瘤发生于脊柱旁交感神经链者明显多于肾上腺者;肿瘤病理亚型以GNB者为主;肿瘤发生部位与其病理亚型相关。.

#2

Dysplastic cerebellar gangliocytoma: a six-decade study.

Journal of neurosurgical sciences2026 Feb

Dysplastic cerebellar gangliocytoma (DCG) is a rare cerebellar tumor glioneuronal and neuronal tumor with phosphatase and tensin homolog (PTEN) identified as a key altered gene. The aim of this study is to establish DCG diagnostic and outcome trends over a six-decade and present cases from our institution. A literature review of online databases was performed using relevant terms (January 1970-October 2024). Our institution pathology database was queried for patients with DCG (2000-2024). Data was extracted and dichotomized in adult and pediatric cases. We report three new DCG cases in addition to the 170 DCG cases reported across 97 articles over seven decades, with 52% of articles published since 2010. DCG predominantly occurred in adults (>18 years, 82%), women (59%), at mean age 9.0±6.3 years and 38.1±13.7 years in pediatric and adult patients, respectively. Balance/coordination deficit, headache and visual deficit were the most common presenting symptoms. MRI "tiger-stripe" pattern was present in 67%. Surgical resection was the treatment of choice for >97% of patients. Association with Cowden Syndrome (CS) was confirmed in 67% of patients. PTEN mutations identified in 48.3% of cases, primarily affecting chromosome 10 (10q23.3). Progression-free survival was experienced by 74% of patients and reoperation for progression needed in 3.5% of cases. DCG is a rare tumor associated with PTEN mutations. MRI aids in diagnosis and surgery ensures favorable outcomes. Standardized genetic screening and targeted therapies require further study, as they hold promise for refining diagnosis and long-term management.

#3

Atypical presentations and neurosurgical Synergy in the treatment of paravertebral tumors in children: Lessons from a single institution.

Pediatrics and neonatology2026 Jan

This study aims to evaluate the surgical management and outcomes of pediatric paravertebral tumors, particularly focusing on dumbbell tumors, within a single medical center. Employing a retrospective analysis at Taichung Veterans General Hospital from January 2016 to February 2022, we included pediatric patients diagnosed with paravertebral tumors confirmed via MRI and histopathology, who underwent surgical treatment. We aimed to assess the extent of tumor resection as the primary outcome, with postoperative complications, recurrence rates, and neurological function as secondary outcomes, utilizing descriptive statistics. In the given period, four pediatric patients, two males and two females aged 53-204 months, were treated at our institute for paravertebral tumors using CT and MRI for diagnosis. The tumors were located in the posterior mediastinum (3 patients) and retroperitoneum (1 patient), with varied MRI findings. Diagnoses included Ganglioneuroma, Schwannoma, Plexiform neurofibroma, and Spindle cell sarcoma. Treatments involved minimally invasive surgeries, with three cases using intraoperative neurological monitoring. Despite a mean operative time of 376 min and a 13-day average hospital stay, one patient experienced recurrence requiring chemotherapy, another had distant metastasis, and one died at a two-year median follow-up. Our study concludes that CT and MRI are crucial for diagnosing paravertebral tumors and planning surgery, and a multidisciplinary approach is essential for optimal functional preservation in pediatric patients. These findings emphasize the necessity for ongoing research to refine treatment strategies and improve patient outcomes in this complex clinical area.

#4

A case of colon Ganglioneuroma resembling an inverted diverticulum on endoscopy.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver2026 Apr
#5

Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma.

Oncology letters2026 May

Telomere maintenance mechanisms (TMM) have garnered attention as a mechanism associated with the treatment resistance and poor prognosis of neuroblastoma (NB). Ganglioneuroblastoma (GNB) and ganglioneuroma (GN) are histologically classified as neuroblastic tumors (NTs) along with NB; however, few reports have addressed TMM in GNB and GN. The present study analyzed 321 NTs diagnosed in Japan, including 255 NB cases, 48 GNB cases and 18 GN cases, using a quantitative PCR-based C-circle assay for alternative lengthening of telomeres (ALT) and a telomerase reverse transcriptase (TERT) mRNA expression assay. ALT was identified in 38 NB cases (38/255, 15%) and 6 GNB cases (6/48, 12.5%), but not in GN. High TERT expression was observed in 38% (64/169), 23% (7/31) and 14% (1/7) of NB, GNB and GN cases, respectively. TMM activation, defined as ALT(+) and/or high TERT expression, occurred in 12/48 GNB cases and 1/18 GN cases, particularly in the GNB-nodular type (10/21, 48%), which was similar to 39% (100/255) of NB cases. Furthermore, TMM(+) GNBs exhibited distinct features, including a high frequency of ATRX alterations and a lower frequency of TERT rearrangements. Chromosomal aberration analysis revealed frequent 7q gain, 17q gain and 11q loss in ALT(+) NTs (83%). Overall, TMM serves as a poor prognostic marker for high-risk NB and offers valuable insights for the risk classification of GNBs.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.208 artigos no totalmostrando 200

2026

Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma.

Oncology letters
2026

Cavitary Pulmonary Blastomycosis and an Incidental Retroperitoneal Ganglioneuroma Mimicking Metastatic Disease.

Cureus
2026

[Correlation study between tumor location and pathological subtypes of neuroblastic tumors associated with opsoclonus myoclonus ataxia syndrome].

Zhonghua er ke za zhi = Chinese journal of pediatrics
2026

Stereotactic Body Radiation Therapy in the Management of Recurrent Unresectable Retroperitoneal Ganglioneuroma.

Cureus
2026

An Unexpected Diagnosis After a Viral Infection: A Case of a Giant Mediastinal Ganglioneuroma.

Cureus
2026

Bilateral pheochromocytoma as a late presentation of neurofibromatosis type 1.

Endocrinology, diabetes &amp; metabolism case reports
2026

Can indocyanine green fluorescence aid operative decision making in neuroblastic tumour surgery? Early experience from a single centre.

Journal of pediatric surgery
2026

A case of colon Ganglioneuroma resembling an inverted diverticulum on endoscopy.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
2025

Total laparoscopic excision of pelvic retroperitoneal ganglioneuroma: a case report and review of the literature.

Frontiers in surgery
2026

Mixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients.

Acta neuropathologica communications
2026

Pathology of peripheral neuroblastic tumors.

Diagnostic pathology
2026

Adrenal schwannomas and adrenal ganglioneuromas: our experience and CT characteristic-focused systematic review.

Endocrine
2025

Ganglioneuroma has a potential for lymph node metastasis, not impacting recurrence.

Frontiers in oncology
2026

Serum steroid profiling by LC-MS/MS in distinguishing adrenocortical carcinoma from other indeterminate adrenal masses.

The Journal of steroid biochemistry and molecular biology
2025

Resection of bilateral dumbbell C2 ganglioneuroma.

Journal of spine surgery (Hong Kong)
2026

A case of giant retroperitoneal ganglioneuroma encasing major vascular structures.

Journal of surgical case reports
2026

Cavernous ganglioneuroma of the thoracic spine: surgical nuances and outcomes following limited anterior resection.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
2026

Copy-Number Aberrations in Circulating Tumor DNA Enable Diagnosis and Risk Stratification of Pediatric Neuroblastic Tumors.

Cancer research communications
2026

[Clinicopathological and molecular genetic features of pediatric malignant peripheral nerve sheath tumors originating from ganglioneuroma/ganglioneuroblastoma].

Zhonghua bing li xue za zhi = Chinese journal of pathology
2025

Multiple Endocrine Neoplasia Type 5 due to Germline MAX Mutations: A Systematic Review of Tumor Spectrum and Clinical Features.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
2025

Mixed gangliocytoma-silent somatotroph pituitary adenoma: a rare variant with pregnancy-associated growth.

BMJ case reports
2025

Non-Syndromic Ganglioneuromatosis of the Gallbladder, an Extremely Rare Condition: Case Report and Literature Review.

Reports (MDPI)
2025

A potentially dangerous case of mistaken identity: giant asymptomatic composite phaeochromocytoma.

Endocrinology, diabetes &amp; metabolism case reports
2025

18F-FDG PET/CT manifestations of extra-adrenal retroperitoneal ganglioneuroma: a retrospective study of 21 cases.

Annals of nuclear medicine
2025

Surgical management of a giant retrorectal ganglioneuroma via an open anterior approach: a case report.

Annals of medicine and surgery (2012)
2025

Retroperitoneal and pelvic schwannoma/neurofibroma resection: surgical strategies and outcomes in a neurosurgical cohort.

Acta neurochirurgica
2026

Adult retroperitoneal Ganglioneuroma: Case report of an incidental mass treated with robotic excision.

Urology case reports
2025

Preoperative differentiation of retroperitoneal ganglioneuroma and schwannoma using an ultrasonography-based multivariable model and simplified score: development and single-center internal validation.

Frontiers in surgery
2024

[Ganglioneuroma of the Small Intestine Mimicking Crohn's Disease].

Acta gastroenterologica Latinoamericana
2025

Dumbbell ganglioneuroma of the lumbar spine: a case report and literature review.

Frontiers in surgery
2025

Atypical Polypoid Ganglioneuroma Initially Detected by Ultrasonography With Signs of Intussusception: A Case Report.

Journal of clinical ultrasound : JCU
2025

Clinical features and oncologic outcomes of primary retroperitoneal ganglioneuroma: a retrospective cohort study of 51 patients from a high-volume sarcoma center.

Frontiers in surgery
2025

Histologic Response to Induction Chemotherapy in High-Risk Neuroblastoma.

Cancer medicine
2025

The Advancing Frontier: Robotic-Assisted Laparoscopy in Pediatric Tumor Management.

Indian journal of surgical oncology
2025

Colonic Ganglioneuroma-A Rare Finding During Colonoscopy.

Diagnostics (Basel, Switzerland)
2025

Multivisceral Resection for Suspected Adrenocortical Carcinoma.

Journal of clinical medicine
2026

Dysplastic cerebellar gangliocytoma: a six-decade study.

Journal of neurosurgical sciences
2025

[Adrenal ganglioneuroma].

Arkhiv patologii
2025

Giant retroperitoneal ganglioneuroma with lumbar nerve root involvement in a child: a case report and a systematic review of literature.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
2025

Laparoscopic management of multiple retroperitoneal ganglioneuromas with 5-year follow-up: a case report.

BMC urology
2025

End-to-end deep learning model for the diagnosis and segmentation of primary retroperitoneal neoplasm: a multicenter cohort study.

EClinicalMedicine
2025

New heights in CT differentiation of adrenal lesions and a rational definition of non-enhancement.

BMC medical imaging
2025

3D Model-Guided Robot-Assisted Giant Presacral Ganglioneuroma Exeresis by a Uro-Neurosurgeons Team: A Case Report.

Reports (MDPI)
2025

Lateral transperitoneal laparoscopic adrenalectomy: A single-centre experience of 21 procedures.

Open medicine (Warsaw, Poland)
2025

Left robotic assisted thoracic surgery (RATS) stellate ganglion ganglioneuroma resection with post-operative Harlequin syndrome.

Multimedia manual of cardiothoracic surgery : MMCTS
2025

Resection of a ganglioneuroma encasing major blood vessels using three-dimensional laparoscopy combined with organ suspension: A case report.

World journal of gastrointestinal surgery
2025

A Rare Case: Composite Paraganglioma-Ganglioneuroma in a Neurofibromatosis 1 Patient and Literature Review.

Neuro endocrinology letters
2025

Parapharyngeal Space Ganglioneuroma in a Child: A Report of a Rare Case.

Cureus
2025

Clinical features and surgical treatment of mediastinal masses in children: a retrospective study of 51 cases.

Frontiers in pediatrics
2025

Complete resection of an incidentally discovered posterior mediastinal ganglioneuroma in an asymptomatic child: a case report.

Journal of surgical case reports
2026

Unveiling Adrenal Ganglioneuroma in a 6-Year-Old Boy: Imaging Insights and Minimally Invasive Treatment.

Journal of clinical ultrasound : JCU
2025

Surprise Diagnosis of a Lumbar Mass: Cytological Diagnosis of Retroperitoneal Ganglioneuroma in a Rare Presentation.

Diagnostic cytopathology
2025

Rare Presentation of Cervical Ganglioneuroma: A Case Report.

Cureus
2025

Subcostal approach using the single-port robotic system for a giant ganglioneuroma in a child.

JTCVS techniques
2025

Adrenal ganglioneuroma: two case reports and literature review.

Frontiers in oncology
2025

Comparative analysis of growth hormone-secreting mixed gangliocytomas and pure growth hormone pituitary adenomas.

Clinical neurology and neurosurgery
2025

Composite gangliocytoma/neuroma and neuroendocrine tumour: a contemporary analysis of 71 cases shows risk factors for metastasis.

Histopathology
2025

Predictive model based on blood cell analysis and coagulation function indicators for neuroblastic tumors staging diagnosis.

Frontiers in oncology
2025

Genetic evaluation of five patients with ROHHAD-NET using whole genome sequencing and optical genome mapping.

Orphanet journal of rare diseases
2025

Adrenal Incidentaloma Masquerading as Malignancy: A Rare Case of Ganglioneuroma with Nodal Metastasis.

Case reports in oncology
2025

Dysplastic gangliocytoma of the cerebellum with an unusual radiological finding.

Ceskoslovenska patologie
2025

Ganglioneuroma: a rare disease that simulates malignancy.

Medicina clinica
2025

Case Report: Malignant transformation of ganglioneuroma in the rectovaginal septum to malignant peripheral nerve sheath tumor based on neurofibromas.

Frontiers in oncology
2025

A rare presentation of a sacral mass: Ganglioneuroma.

Radiology case reports
2026

Atypical presentations and neurosurgical Synergy in the treatment of paravertebral tumors in children: Lessons from a single institution.

Pediatrics and neonatology
2025

The clinical spectrum of adrenal ganglioneuromas extends from severe hypertension to an asymptomatic incidentaloma; two cases and mini review of literature.

Hormones (Athens, Greece)
2025

Diagnostic Challenges and Updates in Peripheral Neuroblastic Tumors.

Surgical pathology clinics
2025

Transperitoneal Laparoscopic Adrenalectomy in Children - Initial Experience in an Emerging Tertiary Center in Eastern India.

Journal of Indian Association of Pediatric Surgeons
2025

Adrenal Ganglioneuroma Masquerading as a Suspicious Adrenal Incidentaloma: A Case Report and Review of the Literature.

Cureus
2026

SS18::POU5F1-fused sarcoma of the parotid with divergent ganglioneuromatous differentiation-a novel manifestation of a rare tumor.

Virchows Archiv : an international journal of pathology
2025

Precision en-bloc retroperitoneal paraganglioma resection performed laparoscopically: A case report.

World journal of clinical cases
2025

Tertiary Lymphoid Structures Are Associated with Progression-Free Survival of Peripheral Neuroblastic Tumor Patients.

Cancers
2025

Rare Adrenal Tumors and Adrenal Metastasis.

The Urologic clinics of North America
2025

An Exophytic Pancreatic Mass Diagnosed as Ganglioneuroma.

ACG case reports journal
2025

A rare case of a composite phaeochromocytoma-ganglioneuroma in Australia.

Journal of surgical case reports
2025

Synchronous Ipsilateral Adrenal and Retroperitoneal Ganglioneuroma: A Unique Case of Large Tumor Mass.

Case reports in medicine
2025

Stereotactic radiosurgery for brain metastases secondary to adrenal ganglioneuroblastoma: illustrative case.

Journal of neurosurgery. Case lessons
2025

Neural or Neural-Related Colorectal Lesion Incidence Varies by Site, and Multifocal Cases Are Often Syndromic: Insights From a Series of 593 Patients.

Archives of pathology &amp; laboratory medicine
2025

Composite Pheochromocytoma-Paraganglioma With Ganglioneuroma: A Dual-Center Clinical Experience.

Journal of the Endocrine Society
2025

Composite Ganglioneuroma and Schwannoma of the Cervical Sympathetic Chain: A Case Report.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
2025

[Retroperitoneal Ganglioneuroma with Multifocal Bone Involvement in a Middle-Aged Woman].

Hinyokika kiyo. Acta urologica Japonica
2025

Proteomic analysis reveals chromatin remodeling as a potential therapeutical target in neuroblastoma.

Journal of translational medicine
2025

Retroperitoneal ganglioneuroma simulating lymphoma: An unusual case presentation.

Radiology case reports
2025

Adrenocorticotropin-Secreting Pure Adrenal Ganglioneuroma Leading to Cushing Syndrome.

JCEM case reports
2025

Laparoscopic resection of neurogenic presacral tumors.

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2025

Two Cases of Composite Pheochromocytoma-Ganglioneuromas With Plasma Metanephrine Levels in the Subclinical Range Pheochromocytoma-Ganglioneuroma.

AACE clinical case reports
2025

A rare case of lipomatous ganglioneuroma of the adrenal gland.

Urology case reports
2025

A Single-Institution Analysis of Surveillance Practice for Low-Risk Neuroblastic Tumors.

The Journal of surgical research
2024

Mature Adrenal Ganglioneuroma With Lipomatous Content: A Radiological and Histopathological Diagnostic Challenge.

Cureus
2025

Advances in multimodal imaging for adrenal gland disorders: integrating CT, MRI, and nuclear medicine.

Japanese journal of radiology
2024

Adolescent thoracic scoliosis due to giant ganglioneuroma: a two-case report and literature review.

Nagoya journal of medical science
2024

[Adrenal tumors in pediatric patients treated with minimally invasive surgery].

Andes pediatrica : revista Chilena de pediatria
2025

Ampullary composite gangliocytoma/neuroma and neuroendocrine tumor management.

Endocrine-related cancer
2025

ROHHAD NET in Retrospect: Key Lessons Learned from Five Cases.

Indian journal of pediatrics
2024

Arterio-Ureteral Fistula as a Long-term Complication Following Retroperitoneal Presacral Ganglioneuroma Resection: Case Report in an Adolescent and Review of the Literature.

European journal of pediatric surgery reports
2024

An intracranial odyssey: pediatric ganglioneuroma arising from the trigeminal ganglion: a case report and review of the literature.

Journal of medical case reports
2024

Ganglioneuroma: a rare appendiceal tumour - case report and literature review.

Journal of surgical case reports
2025

Asymptomatic retroperitoneal ganglioneuroma adjacent to the abdominal organs and large abdominal vessels.

Polish archives of internal medicine
2024

Dysplastic ganglion cell tumor of the right cerebellum: A case report and literature review.

Medicine
2025

Combined Ganglioneuroma-Schwannoma of the Retroperitoneum: An Exceedingly Rare Hybrid Nerve Sheath-Ganglioneural Tumor.

International journal of surgical pathology
2024

Toe Walking Secondary to Tethered Spinal Cord Caused by Ganglioneuroma: A Case Report.

Cureus
2024

Characterisation of Paediatric Neuroblastic Tumours by Quantitative Structural and Diffusion-Weighted MRI.

Journal of clinical medicine
2025

Management of Ganglioneuroma and Ganglioneuroblastoma Intermixed: A United Kingdom Children's Cancer and Leukaemia Group (UK CCLG) Nationwide Study Report.

Pediatric blood &amp; cancer
2025

Pathologists' integration of prior biopsies of women with germline PTEN mutations may expedite the identification of this rare cancer predisposition syndrome.

Pathology
2024

Cervical Ganglio-neuroma, a Rare Neck Mass in Pediatric Age: A Case Report.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
2025

Mixed Gangliocytoma-Pituitary Adenoma: A Systematic Review of Diagnostic Features, Clinical Management, and Surgical Outcomes.

World neurosurgery
2024

Giant ganglioneuroma of the mediastinum: a case report.

Frontiers in oncology
2024

Ganglioneuroma in Head and Neck: A Case Report of a Laryngeal Ganglioneuroma and a Systematic Review of the Literature.

Cancers
2024

Unraveling the glycosphingolipid metabolism by leveraging transcriptome-weighted network analysis on neuroblastic tumors.

Cancer &amp; metabolism
2025

Solitary Colonic Ganglioneuroma With Central Depression: A Rare Case With Unique Morphology.

The American journal of gastroenterology
2024

Adrenal Ganglioneuroma With Radiology-Pathology Correlation.

Cureus
2024

Adrenal ganglioneuroma with retroperitoneal lymph node metastasis: A rare scenario.

Journal of cancer research and therapeutics
2024

Ganglioneuroma of the cervical sympathetic chain: A case report and review of literature.

Radiology case reports
2024

An extremely rare case of presacral ganglioneuroma in a young male with lower back pain: First case report from Iraq.

Radiology case reports
2024

Case Report: Adrenal schwannoma associated with ganglioneuroma.

Frontiers in surgery
2024

Vasoactive Intestinal Peptide-Producing Neuroblastic Tumors: A Rare Cause of Refractory Diarrhea.

Cureus
2024

Bilateral choroidal ganglioneuroma: a comprehensive analysis of vision decline in a 6-year-old boy.

International journal of ophthalmology
2024

Adrenal ganglioneuroma with nodal metastases on 123I-MIBG SPECT/CT and 18F-FDG PET/CT.

Radiology case reports
2024

Invasive trigeminal ganglioneuroma: A case report and review of the literature.

Acta radiologica open
2024

Spinal ganglioneuroma: a rare and challenging tumor in the pediatric population.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery
2024

Laparoscopic resection for retroperitoneum ganglioneuroma with Supine hypotension syndrome.

Surgical case reports
2024

Paravertebral Ganglioneuroma in Pediatric Age: A Case Report.

Cureus
2024

Case report: Treatment response of NF-1-associated bladder ganglioneuroma to trametinib.

Frontiers in oncology
2024

Giant mediastinal ganglioneuroma in adolescents.

Asian journal of surgery
2024

Two rare cases of giant ganglioneuroma of the posterior mediastinum in overweight children.

Asian journal of surgery
2024

Esophageal ganglioneuromatosis; a rare cause of intractable esophageal stenosis: a case report.

BMC pediatrics
2024

Ganglioneuromatous polyposis associated with type 2 B multiple endocrine neoplasia (MEN 2B) - case report.

Annals of agricultural and environmental medicine : AAEM
2024

Successful endoscopic approach for peripheral neuroblastic tumors in children.

Pediatrics international : official journal of the Japan Pediatric Society
2024

Mixed pituitary adenoma/pituitary neuroendocrine tumor-gangliocytoma: Immunohistochemical insights.

Journal of neuropathology and experimental neurology
2025

Expression of GD2 and GD3 in peripheral neuroblastic tumors.

Indian journal of pathology &amp; microbiology
2024

A head-to-head comparison of computed tomography- and magnetic resonance imaging-based radiomics in assessing pediatric peripheral neuroblastic tumor cell behavior.

Abdominal radiology (New York)
2024

Giant Ganglioneuroma of the Lumbar Spine: A Rare Cause of Radiculopathy.

Case reports in surgery
2024

Cervical ganglioneuroma as a rare cause of cervicogenic headache: A case report and literature review.

Journal of back and musculoskeletal rehabilitation
2024

Rare adrenal incidentaloma: ganglioneuroma.

Journal of surgical case reports
2024

Robotic thoracic surgery for neurogenic tumors.

Journal of neurosurgery
2024

Large retroperitoneal ganglioneuroma revealed by a left ovarian endometrioma: A case report.

SAGE open medical case reports
2024

Spinal ganglioneuroma with extension to the brachial plexus. The challenges for total surgical excision, a case report.

International journal of surgery case reports
2024

Multiple endocrine neoplasia type 2B diagnosed after small intestinal volvulus with progressive megacolon in an adolescent.

Clinical journal of gastroenterology
2024

Massive Silent abdominal ganglioneuroma in the setting of non-Hodgkin lymphoma : A rare case report.

International journal of surgery case reports
2024

A novel method of tunneling retroperitoneoscopic adrenalectomy: a prospective study.

BMC urology
2024

[Intraspinal composite gangliocytoma/neuroma and neuroendocrine tumor with vascular malformation: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology
2024

Combined unilateral biportal endoscopy and video-assisted thoracoscopic surgery for complete excision of a T3-T4 right ganglioneuroma.

Neurosurgical focus: Video
2024

A Preliminary Study on the Application of Contrast-Enhanced Ultrasonography in Children With Peripheral Neuroblastic Tumors.

Ultrasound in medicine &amp; biology
2024

Solitary Ganglioneuromatous Hamartoma Tongue in a Newborn - A Rare Entity.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
2024

Laryngeal Ganglioneuromatosis in a Child With Multiple Endocrine Neoplasia Type 2B (MEN2B): Case Report and Review of Literature.

Cureus
2024

A Woman with Bilateral Pheochromocytoma and Tuberous Sclerosis Complex.

AACE clinical case reports
2024

Neuroganglioma in the posterior mediastinum: an incidental discovery.

Journal of surgical case reports
2024

Clinical features and treatment options for pediatric adrenal incidentalomas: a retrospective single center study.

BMC pediatrics
2025

Double-balloon enteroscopy for the detection of GIST in a patient with type 1 neurofibromatosis.

Revista espanola de enfermedades digestivas
2024

[Surgically Resected Cases of Mediastinal Ganglioneuroma Detected in Adults].

Kyobu geka. The Japanese journal of thoracic surgery
2024

Cervical Ganglioneuroma Associated With Neurofibromatosis Type 1.

The Journal of craniofacial surgery
2024

Robotic excision of a retrocaval ancient schwannoma: a case report.

Journal of surgical case reports
2024

Ganglioneuroma of the Cervical Sympathetic Chain - A Rare Occurrence.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
2024

Benign paraspinal ganglioneuroma with paraneoplastic opsoclonus myoclonus syndrome.

BMJ case reports
2024

A case of thoracic intraspinal ganglioneuroma with intermittent fever as the main symptom.

Asian journal of surgery
2024

Retroperitoneal Peripancreatic Ganglioneuroma Encasing the Celiac Trunk and Superior Mesenteric Artery.

Cureus
2024

Appendiceal ganglioneuroma incidentally found during resection of recurrent rectal cancer: case report and review of the literature.

Journal of surgical case reports
2023

[Intestinal ganglioneuromatosis as an early extra-endocrine manifestation of type 2B multiple endocrine neoplasia].

Problemy endokrinologii
2024

Anti-metabolic glutamate receptor 5 encephalitis with gangliocytoma: a case and review of the literature.

BMC neurology
2024

Robotic-assisted surgery for gynecological indications in children and adolescents: European multicenter report.

Journal of robotic surgery
2023

A case report of multimodal ultrasound imaging in the diagnosis of giant retroperitoneal ganglioneuroma.

Cancer innovation
2023

Synchronous ipsilateral adrenal cortical adenoma and ganglioneuroma: A case report.

Indian journal of urology : IJU : journal of the Urological Society of India
2023

Diagnostic imaging of a rare case of incidental adrenal ganglioneuroma.

Acta bio-medica : Atenei Parmensis
2024

Ganglioneuroma presents as the absence of sweating on the face and the opposite trunk in a child.

Pediatric pulmonology
2023

N6-methyladenosine-mediated overexpression of long noncoding RNA ADAMTS9-AS2 triggers neuroblastoma differentiation via regulating LIN28B/let-7/MYCN signaling.

JCI insight
2024

Colorectal Ganglioneuromas Associated with Cowden Syndrome.

Internal medicine (Tokyo, Japan)
2023

Epidemiological and clinical characteristics of children with peripheral neuroblastic tumors: a study on a Moroccan population.

Journal of cancer research and clinical oncology
2024

Composite paraganglioma-ganglioneuroma with atypical catecholamine profile and phenylethanolamine N-methyltransferase expression: a case report and literature review.

Endocrine journal
2025

Late Relapse in Neuroblastoma: Case Report and Review of the Literature.

Current pediatric reviews
2023

A not so incidental 'incidentaloma' - pediatric ganglioneuroma-associated cerebellar degeneration and super-refractory status epilepticus: case report and literature review.

Frontiers in neurology
2023

Localized Multifocal Retroperitoneal Ganglioneuroma with an Infiltrative Appearance on Imaging: A Case Report.

Case reports in oncology
2023

A rare entity: Ganglioneuroma of the prostate.

Urology case reports
2024

Laparoscopic Transperitoneal Adrenalectomy for Adrenal Tumors in Children: Technical Considerations and Surgical Experience.

Journal of laparoendoscopic &amp; advanced surgical techniques. Part A
2024

Ganglioneuromas in Childhood: Hacettepe Experience With 70 Cases.

Journal of pediatric surgery
2023

Musashi-2 (MSI2) promotes neuroblastoma tumorigenesis through targeting MYC-mediated glucose-6-phosphate dehydrogenase (G6PD) transcriptional activation.

Medical oncology (Northwood, London, England)
2023

Preoperative differentiation of mediastinum and retroperitoneum ganglioneuroma from schwannoma with clinical data and enhanced CT: developing a multivariable prediction model.

Clinical radiology
2023

Laparoscopic resection of ganglioneuroma from the hepatoduodenal ligament: A case report.

International journal of surgery case reports
2023

[Peripheral neuroblastic tumors in childhood].

Pathologie (Heidelberg, Germany)
2023

A Sizeable Adrenal Ganglioneuroma: A Case Report.

Cureus
2023

A case report on POEMS syndrome with high parathyroid hormone and repeated surgery, a rare presentation of a rare disease.

International journal of surgery case reports
2023

Single-cell transcriptome sequencing reveals tumor heterogeneity in family neuroblastoma.

Frontiers in immunology
2023

Computer-assisted resection of multifocal primary neuroblastic tumors: A case report.

Asian journal of surgery
2023

Nonspecific Gastrointestinal Symptoms as the First Sign of Ganglioneuroblastoma Intermixed-Case Report and Literature Review.

Journal of clinical medicine
2023

Operative challenges in a gigantic ganglioneuroma of the posterior mediastinum with mediastinal compression.

Journal of surgical case reports
2023

Overreliance on Radiological Findings Leading to Misdiagnosed Giant Retroperitoneal Ganglioneuroma: A Case Report and Literature Review.

Cureus
2023

Retroperitoneal ganglioneuroma: A five-case series from a single Tunisian center.

International journal of surgery case reports
2024

Coexistence of a small bowel gastrointestinal stromal tumor, small bowel adenocarcinoma and ganglioneuroma in a patient with neurofibromatosis type I caused intussusception.

Revista espanola de enfermedades digestivas
2023

Maturation of metastases in peripheral neuroblastic tumors (neuroblastoma) of children.

Journal of neuropathology and experimental neurology
2023

Composite pheochromocytoma associated with neurofibromatosis type 1.

IJU case reports
2023

Neck Ganglioneuroma Mimicking a Thyroid Nodule in a Four-Year-Old Child: A Case Report and Review of the Literature.

International journal of endocrinology and metabolism
2024

En Bloc Resection of a Giant Ganglioneuroma of the Chest Through Clamshell Thoracotomy.

World journal for pediatric &amp; congenital heart surgery
2023

Spinal Ganglioneuroma: A Systematic Review of the Literature.

World neurosurgery
2024

Neuropil-like islands are a possible pathogenetic link between glioblastoma and gangliocytoma/ganglioglioma in a case of synchronous bilateral brain tumors.

Neuropathology : official journal of the Japanese Society of Neuropathology
2023

Intraparotid Ganglioneuroma: A rare case report.

Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India
2023

Ganglioneuroma presenting as subpulmonic effusion-a differential to consider?

Indian journal of thoracic and cardiovascular surgery
2023

Image-defined risk factors in localized thoracic neuroblastoma and ganglioneuroma.

Pediatric blood &amp; cancer
2023

Adrenal ganglioneuroma: Features and outcomes of cases series.

Asian journal of surgery
2023

Imaging of Ganglioneuroma: A Literature Review and a Rare Case of Cystic Presentation in an Adolescent Girl.

Diagnostics (Basel, Switzerland)
2023

Diagnosis of PTEN mosaicism: the relevance of additional tumor DNA sequencing. A case report and review of the literature.

BMC medical genomics
2023

Clinical Characteristics and Long-Term Outcomes of Adrenal Tumors in Children and Adolescents.

Experimental and clinical endocrinology &amp; diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
Ver todos os 1.208 no EuropePMC

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. [Correlation study between tumor location and pathological subtypes of neuroblastic tumors associated with opsoclonus myoclonus ataxia syndrome].
    Zhonghua er ke za zhi = Chinese journal of pediatrics· 2026· PMID 41834205mais citado
  2. Dysplastic cerebellar gangliocytoma: a six-decade study.
    Journal of neurosurgical sciences· 2026· PMID 41148183mais citado
  3. Atypical presentations and neurosurgical Synergy in the treatment of paravertebral tumors in children: Lessons from a single institution.
    Pediatrics and neonatology· 2026· PMID 40517080mais citado
  4. A case of colon Ganglioneuroma resembling an inverted diverticulum on endoscopy.
    Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver· 2026· PMID 41692647mais citado
  5. Telomere maintenance mechanisms are activated in ganglioneuroblastoma and ganglioneuroma.
    Oncology letters· 2026· PMID 41858373mais citado
  6. A rare case of retroperitoneal ganglioneuroma in adult: diagnostic and management challenges.
    J Surg Case Rep· 2026· PMID 41993113recente
  7. A giant cervical ganglioneuroma in a middle-aged man: a case report.
    Front Oncol· 2026· PMID 41971427recente
  8. Not all that wheezes is asthma: A pediatric posterior mediastinal ganglioneuroma mimicking recurrent asthma.
    Respir Med Case Rep· 2026· PMID 41940317recente
  9. Ganglioneuroma in a Meller's chameleon (Triocerosmelleri).
    J Comp Pathol· 2026· PMID 41886882recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:251992(Orphanet)
  2. MONDO:0005033(MONDO)
  3. GARD:20731(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Busca completa no PubMed(PubMed)
  6. Q1124606(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Ganglioneuroma
Compêndio · Raras BR

Ganglioneuroma

ORPHA:251992 · MONDO:0005033
CID-10
D36.1 · Neoplasia benigna dos nervos periféricos e sistema nervoso autônomo
CID-11
Ensaios
5 ativos
Início
Adolescent, Childhood, Infancy
MedGen
UMLS
C0017075
EuropePMC
Wikidata
Papers 10a
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