Um tipo de câncer que geralmente não causa dor e que se forma na gordura do corpo. Quando visto no microscópio, ele pode mostrar uma variedade de células de gordura cancerosas, que vão desde as células jovens de gordura (chamadas lipoblastos) até células de gordura malignas com formatos muito irregulares (pleomórficas). Os tipos que ele pode ser incluem: lipossarcoma bem diferenciado, desdiferenciado, pleomórfico (com formas variadas) e mixoide. O potencial de se espalhar para outras partes do corpo (metastatizar) é maior nos tumores que são menos diferenciados.
Introdução
O que você precisa saber de cara
O lipossarcoma é um tipo de tumor maligno raro que tem origem nas células de gordura do corpo e que frequentemente se desenvolve sem provocar dor no início. Com o tempo, ele costuma se manifestar por meio de um nódulo sob a pele ou sintomas como dor abdominal, cansaço, perda de peso e mal-estar. O diagnóstico exige a confirmação microscópica do tecido para avaliar o tipo celular e o grau de diferenciação do tumor. No Brasil, a doença não conta com um protocolo clínico (PCDT) próprio nem remédios dispensados exclusivamente para ela no SUS, sendo o tratamento conduzido pela rede geral de oncologia.
Um tipo de câncer que geralmente não causa dor e que se forma na gordura do corpo. Quando visto no microscópio, ele pode mostrar uma variedade de células de gordura cancerosas, que vão desde as células jovens de gordura (chamadas lipoblastos) até células de gordura malignas com formatos muito irregulares (pleomórficas). Os tipos que ele pode ser incluem: lipossarcoma bem diferenciado, desdiferenciado, pleomórfico (com formas variadas) e mixoide. O potencial de se espalhar para outras partes do corpo (metastatizar) é maior nos tumores que são menos diferenciados.
Tem tratamento?
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Entender a doença
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 5 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 14 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
5 genes identificados com associação a esta condição. Padrão de herança: Unknown.
Silver-Russell syndrome 5
A form of Silver-Russell syndrome, a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. SRS5 inheritance is autosomal dominant.
Melanoma, cutaneous malignant 3
A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but may also involve other sites.
Medicamentos aprovados (FDA)
2 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
147 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
41 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Lipossarcoma
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Com ensaio aberto em 24 países. O ponto verde marca onde há vaga agora.
🟢 Recrutando agora
33 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
177 ensaios clínicos encontrados, 57 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 3.816
A Phase 1 Study of Neoadjuvant Cabozantinib in Combination With Radiation Therapy for Sarcomas of the Extremities.
Cabozantinib demonstrates activity in multiple soft tissue sarcoma (STS) subtypes, but use with concurrent radiation therapy (RT) has been limited by concern for risk of fistula or perforation. This phase 1 trial evaluated the safety of concurrent cabozantinib and RT as neoadjuvant therapy in patients with extremity STS. Adults with newly diagnosed localized extremity STS planned for neoadjuvant RT and surgical resection were eligible. Participants received radiation with 5000 to 5040 cGy with conventional fractionation and cabozantinib 40 mg or 60 mg daily. Patients were observed for dose-limiting toxicity (DLT) up to 28 days after completion of concurrent cabozantinib/RT. The primary objective was to identify a recommended phase 2 dose (RP2D) of cabozantinib for combination with RT, and secondary objectives included estimating rates of treatment-related adverse event (TRAE), margin positivity, and objective response. Six patients were enrolled with histologic subtypes of undifferentiated pleomorphic sarcoma, myxofibrosarcoma, leiomyosarcoma, and myxoid liposarcoma. No DLT due to the combination of cabozantinib and radiation was observed, but 3/6 (50%) patients required dose-reduction due to TRAE of cabozantinib alone. No grade ≥3 toxicities were attributed to RT. The RP2D was cabozantinib 60 mg. Six (100%) patients demonstrated stable disease at 12 weeks, and 5 (83%) underwent R0 resection. Two (33%) patients experienced metastatic relapse, and 1 (17%) died without relapse; 3 (50%) patients survived without relapse by last contact. No local recurrences occurred. In this phase 1 trial, concurrent cabozantinib/RT was feasible and demonstrated an acceptable safety profile for patients with extremity STS.
Real-world characterization of patients with advanced or metastatic liposarcoma, including dedifferentiated liposarcoma, in Japan in the MASTER KEY project.
Efficacy of available treatments for liposarcoma (LPS), including dedifferentiated liposarcoma (DDLPS) is limited, and detailed real-world clinical data for patients with LPS treated in Japan are scarce. We used the MASTER KEY Registry Database to evaluate the clinical characteristics and outcomes of patients with advanced/metastatic LPS treated with systemic antineoplastic therapy in Japan. This non-interventional/observational cohort study included patients with LPS, including DDLPS, and well-differentiated LPS (WDLPS), and a history of systemic antineoplastic therapy, enrolled in the MASTER KEY Project Registry Database from 1 May 2017 to 31 December 2022. Outcomes were analysed by type of treatment. Primary outcomes: progression-free survival (PFS); overall survival (OS). Secondary outcomes: overall response rate; disease control rate. Sensitivity analyses (prospective registry subgroup) were performed to minimize immortal time bias. Since 2017, 100 patients with LPS were prospectively enrolled in the database; of these, 62 had DDLPS and 11 had WDLPS. In patients with LPS, median PFS was 11.1 months after first-line (1 L) pharmacotherapy and 6.9 months after 1 L doxorubicin. In patients with DDLPS, median PFS was 6.9 months after 1 L pharmacotherapy and 4.4 months after 1 L doxorubicin. Median OS after 1 L pharmacotherapy was 45.8 months in patients with LPS, and 40.7 months in those with DDLPS. Median OS in the sensitivity analysis was not reached for patients with LPS and was 13.9 months for the DDLPS subgroup. These data investigating DDLPS in Japanese patients highlight the poor outcomes and lack of effective treatment options in the real-world clinical practice setting.
Immunoreactivity for CD34, Desmin, Keratins, KIT, Alpha-Smooth Muscle Actin, S100, and Vimentin in Malignant Mesenchymal Neoplasms in Guinea Pigs: A Series of 62 Cases From a Single Institution.
There has been a lack of research regarding diagnostic immunohistochemistry in soft tissue pathology in rodents. We aimed to analyse the immunohistochemical expression of CD34, keratin AE1/AE3, keratin 8/18, desmin, KIT, SMA, S100, and vimentin in various malignant mesenchymal tumours in guinea pigs. A total of 62 tumours included 10 fibrosarcomas, 8 myxosarcomas, 8 undifferentiated pleomorphic sarcomas, 6 undifferentiated round cell sarcomas, 6 dedifferentiated liposarcomas (involving deep soft tissue, skin or subcutis), 12 uterine leiomyosarcomas, 4 hemangiosarcomas (involving skin and spleen), and 8 gastrointestinal stromal tumours (GIST). Desmin and SMA positivity was present in tumours of various lineages, including hemangiosarcoma. CD34 positivity was restricted to hemangiosarcomas, GISTs and one case of undifferentiated pleomorphic sarcoma, whereas KIT positivity was detected only in GISTs. Lesser amounts of keratins positivity were observed in fibrosarcoma, myxosarcoma, undifferentiated pleomorphic sarcoma, and dedifferentiated liposarcoma. S100 positivity was identified in myxosarcoma, undifferentiated pleomorphic sarcoma, and dediffentiated liposarcoma and vimentin positivity was detected in all tumour types. The strong and diffuse staining pattern of desmin and SMA can be very helpful in distinguishing leiomyosarcoma from its spindle cell mimics. A novel finding is that SMA positivity was identified in malignant endothelium. Immunolabelling for CD34 and KIT provides reliable markers for vascular neoplasms and GISTs. Vimentin does not allow to distinguish between different mesenchymal malignancies in guinea pigs. Occasional positivity for keratins and S100 points to potential pitfalls and emphasised the need for a panel of immunohistochemical stains in the investigation of mesenchymal tumours.
Sarcopenia as an independent prognostic marker in liposarcoma: A longitudinal analysis of body composition and survival.
Sarcopenia is increasingly recognized as an important prognostic factor in oncology; however, its clinical relevance in liposarcoma remains insufficiently defined. This study aimed to evaluate longitudinal changes in CT-derived body composition parameters in liposarcoma patients, to assess the influence of tumor grade, recurrence, and treatment modalities on these parameters and to determine the association of baseline sarcopenia and progressive muscle loss with overall survival and functional status. In a retrospective, single center study between 2010 and 2024, 64 patients were analyzed. All patients underwent surgical tumor resection of a histologically confirmed liposarcoma. Included were patients with two consecutive CT scans. The following morphometric parameters were measured on CT axial images at the height of lumbar vertebral 3: Skeletal muscle index (SMI), paraspinal muscle index (PSMI), psoas muscle index (PMI), skeletal muscle density (SMD), and visceral adipose tissue (VAT). Standardized Hounsfield unit thresholds were used for the assessment. Additionally, the influence of tumor grade, recurrence, and treatment modalities on body composition was assessed. A Kaplan Meier survival analysis was performed using data from the residents´ registration office. Survival was further analyzed by Cox regression using uni- and multivariate models. Metric data was compared using student´s t-test. Significant reductions in SMI, PSMI, PMI, and VAT were observed over the disease course, particularly among patients with high-grade tumors, chemotherapy, or local tumor recurrence. Baseline sarcopenia and a progressive SMI loss were independently associated with reduced overall survival. In multivariate analysis, baseline sarcopenia (HR: 2.331, p = 0.007) and a ≥ 15% SMI decline (HR: 2.601, p = 0.006) remained significant predictors of mortality. Both markers did not correlate with changes in Eastern Cooperative Oncology Group (ECOG) performance status. CT-morphometric parameters deteriorate substantially during the disease course of liposarcoma patients and serve as independent predictors of survival. These findings support the integration of CT-based body composition analysis into routine oncologic assessment and highlight its potential role in identifying high-risk patients for early supportive intervention.
Molecular and Immune Mechanisms Governing Cancer Metastasis, Including Dormancy, Microenvironmental Niches, and Tumor-Specific Programs.
Metastasis is still the leading cause of cancer-related death. It happens when disseminated tumor cells (DTCs) successfully navigate a series of steps and adapt to the unique conditions of distant organs. In this review, key molecular and immune mechanisms that shape metastatic spread, long-term survival, and eventual outgrowth are examined, with a focus on how tumor-intrinsic programs interact with extracellular matrix (ECM) remodeling, angiogenesis, and immune regulation. Gene networks that sustain tumor-cell plasticity and invasion are described, including EMT-linked transcription factors such as SNAIL and TWIST, as well as broader transcriptional regulators like SP1. Also, how epigenetic mechanisms, such as EZH2 activity, DNA methylation, chromatin remodeling, and noncoding RNAs, lock in pro-metastatic states and support adaptation under therapeutic pressure. Finally, proteases and matrix-modifying enzymes that physically and biochemically reshape tissues, including MMPs, uPA, cathepsins, LOX/LOXL2, and heparinase, are discussed for their roles in releasing stored growth signals and building permissive niches that enable seeding and colonization. In parallel, immune-evasion strategies that protect circulating and newly seeded tumor cells are discussed, including platelet-mediated shielding, suppressive myeloid populations, checkpoint signaling, and stromal barriers that exclude effector lymphocytes. A major focus is metastatic dormancy, cellular, angiogenic, and immune-mediated, framed as a reversible survival state regulated by stress signaling, adhesion cues, metabolic rewiring, and niche constraints, and as a key determinant of late relapse. Tumor-specific metastatic programs across mesenchymal malignancies (osteosarcoma, chondrosarcoma, and liposarcoma) and selected high-burden cancers (melanoma, hepatocellular carcinoma, glioblastoma, and breast cancer) are highlighted, emphasizing shared principles and divergent organotropisms. Emerging therapeutic strategies that target both the "seed" and the "soil" are also discussed, including immunotherapy combinations, stromal/ECM normalization, chemokine-axis inhibition, epigenetic reprogramming, and liquid-biopsy-enabled minimal residual disease monitoring, to prevent reactivation and improve durable control of metastatic disease.
Publicações recentes
Giant Adenomatoid Tumor of the Tunica Albuginea Presenting as Chronic Scrotal Swelling in an Elderly Male: A Report of a Rare Case.
ATRX loss in sarcomas is associated with dysregulated gene and transposable element expression, loss of DNA methylation, and worse survival.
XPO1 inhibitor KPT-330 disrupts the core transcriptional regulatory circuitry of dedifferentiated liposarcoma by modulating the translation process.
AI-derived CT morphometric phenotypes predict survival, functional decline, and surgical morbidity following curative-intent surgical sarcoma resection.
Laryngopharyngeal Liposarcoma: A (Somewhat Docile) Wolf in Sheep's Clothing.
📚 EuropePMC4.558 artigos no totalmostrando 198
Madelung's disease involving the scrotum: a case report and diagnostic pitfalls with liposarcoma.
Frontiers in oncologyA case report of extra-adrenal retroperitoneal myelolipoma.
Frontiers in oncologyDistinct immunologic patterns of response and resistance to anti-PD-1/PD-L1-based immunotherapy in patients with soft tissue sarcoma.
Frontiers in immunologyLong-Term Control of Giant Retroperitoneal Liposarcoma by Proton Beam Therapy Combined With Hyperthermia: A Case Report and Literature Review.
CureusOverall survival from the open-label phase II trial of palbociclib in patients with advanced well-differentiated/dedifferentiated liposarcoma.
ESMO openDedifferentiated liposarcoma originating in the prostate: a rare case report.
Discover oncologyPerinephric Myxoid Pseudotumor of Fat Associated With Complicated Colonic Disease.
International journal of surgical pathologyEx vivo organotypic culture of liposarcoma effectively models in vivo supratherapeutic paclitaxel localized drug delivery.
Translational oncologyMyxoid Pleomorphic Liposarcoma Imitating Recurrent Traumatic Hemopericardium.
JACC. Case reportsMyxoid liposarcoma of the leg: a case report.
BJR case reportsA case of high-grade differentiated liposarcoma in the oesophagus.
BJR case reportsGiant Dedifferentiated Liposarcoma of the Mediastinum.
Annali italiani di chirurgiaSurgical resection for primary retroperitoneal liposarcoma: Analysis of 153 patients treated and followed at a single institution.
Cancer treatment and research communicationsMultidisciplinary Treatment of Inguinoscrotal Sarcomas: Analysis of 39 Cases Treated by Surgical Approach.
CancersWhole Abdominal Radiotherapy in Bone and Soft Tissue Sarcomas: Indications, Techniques, Clinical Outcomes, and Future Directions.
Current treatment options in oncologySafe Resection of a Giant Mediastinal Liposarcoma with Severe Cardiac Compression.
Surgical case reportsA Challenging Case of Pleomorphic Lipoma of the Shoulder Mimicking Liposarcoma.
The American journal of case reportsGiant cervical lipoblastoma in infant: a rare case report.
International journal of surgery case reportsTargeting the Non-Homologous End-Joining Pathway Sensitizes MDM2-Amplified Liposarcoma to Doxorubicin by Enhancing p53-Mediated Senescence.
Cancer researchSurgical Strategies for Closure of Complex Posterior Trunk Defects in Myxoid Pleomorphic Liposarcoma: A Case Report and Literature Review.
CureusSyndromes Aassociated with Lipomatous Tumors (SALT): A comprehensive review.
Human pathologyHeterologous Rhabdomyoblastic Differentiation in Dedifferentiated Liposarcoma Is Significantly Associated With Loss of H3K27 Trimethylation.
Pathology internationalNeoadjuvant radiotherapy for primary retroperitoneal well-differentiated liposarcoma: a Transatlantic Australasian Retroperitoneal Sarcoma Working Group (TARPSWG) propensity score matched analysis.
EClinicalMedicineMyxoid liposarcoma of sigmoid mesocolon: a case report and review of the literature.
Journal of medical case reportsPerformance of deep learning-based segmentation of soft tissue sarcoma by MRI sequence, tumor type and location.
Skeletal radiologyBurden and unmet needs of liposarcoma in the United States: Patient perspectives on the liposarcoma diagnostic journey.
Rare tumorsA Phase 1 Study of Neoadjuvant Cabozantinib in Combination With Radiation Therapy for Sarcomas of the Extremities.
American journal of clinical oncologyHistomorphological Spectrum of Soft Tissue Tumors at a Tertiary Care Hospital.
CureusSurgical resection of pleural lipoma after 9 years of serial imaging.
Journal of cardiothoracic surgeryGlycosphingolipids in human abdominal leiomyosarcoma and liposarcoma.
The Journal of biological chemistryPredictors of survival in dedifferentiated liposarcoma: A population-based analysis of the SEER database.
MedicineReal-world disproportionality analysis of trabectedin using the United States food and drug administration adverse event reporting system.
Naunyn-Schmiedeberg's archives of pharmacologyTargeting tRNA-Arg-TCT-4-1 suppresses cancer cell growth and tumorigenesis.
bioRxiv : the preprint server for biologyIsolated signals in BCL2, MYC, BCL6, and DDIT3 FISH: implications for genetic alterations and protein dysregulation.
Pathology oncology research : PORClinicopathological characteristics and outcomes of 42 cases of ocular adnexal sarcoma.
International ophthalmology[Sarcomas : Clinical introduction].
Radiologie (Heidelberg, Germany)Primary Dedifferentiated Liposarcoma of the Duodenum: A Report of a Rare Case With a Review of the Literature.
CureusCommentary: Undifferentiated pleomorphic sarcoma of the adrenal gland: a case report and literature review.
Frontiers in oncology[Persistent electrolyte deficiency in an oncology patient].
PraxisParatesticular sarcoma of the spermatic cord: A rare case of dedifferentiated leiomyosarcoma.
Urology case reportsDedifferentiated Liposarcoma of the Epididymis: A Rare Case Report and Analysis.
Current medical imagingFat-containing soft-tissue tumors: Imaging findings and pathologic correlation.
Skeletal radiologyPercutaneous Cryoablation for Sternal Bone Metastases: A Retrospective Study.
Journal of vascular and interventional radiology : JVIRSoft tissue and juxtaarticular tumors of the knee.
Skeletal radiologyComplete Resection of a Giant Mediastinal Liposarcoma Extending Into Both Pleural Cavities via Median Sternotomy: A Case Report.
Clinical case reportsUltrasound-Guided Preoperative SAVI SCOUT Radar Reflector Localization of Soft Tissue Masses in the Musculoskeletal System: A Retrospective Case-Control Study of Operative Times and Reoperation Rates.
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in MedicineIntratumor heterogeneity and clonal evolution in sarcomas: Molecular, cellular, and functional drivers of therapy resistance.
Seminars in cancer biologySurgical outcomes and prognostic factors in patients with retroperitoneal tumors: a single-center retrospective cohort study (2015-2024).
Annals of surgical treatment and researchParatesticular dedifferentiated liposarcoma with rhabdomyosarcomatous differentiation presenting as hydrocele in an older man: a case report.
Annals of medicine and surgery (2012)An Unusually Large Oral Lipoma of Buccal Mucosa and Vestibulum: A Case Report.
Case reports in dentistryMRI findings for differentiating benign and malignant soft tissue tumors: a systematic review-part 2: key imaging findings.
Skeletal radiologyReal-world characterization of patients with advanced or metastatic liposarcoma, including dedifferentiated liposarcoma, in Japan in the MASTER KEY project.
Japanese journal of clinical oncologyPlasmonic Truncated Satellite Octahedral Nanoparticles: Interior Nanocavities and Exterior Nanotrenches Synergistically Maximize Near-Field Focus.
Nano lettersThe anti-apoptotic protein lifeguard is expressed in osteosarcoma, chondrosarcoma and soft tissue sarcoma.
OncologyImmunoreactivity for CD34, Desmin, Keratins, KIT, Alpha-Smooth Muscle Actin, S100, and Vimentin in Malignant Mesenchymal Neoplasms in Guinea Pigs: A Series of 62 Cases From a Single Institution.
Veterinary medicine and scienceIntermuscular Hibernoma of the Thigh: A Diagnostic and Surgical Challenge Managed With Preoperative Embolization.
CureusSarcopenia as an independent prognostic marker in liposarcoma: A longitudinal analysis of body composition and survival.
PloS oneA rare case of deep fibrous histiocytoma with low-grade myxoid and dedifferentiated liposarcoma features: clinical, radiological, and histopathological insights.
Journal of surgical case reportsColossal well-differentiated liposarcoma of the small bowel mesentery: A case report.
World journal of gastrointestinal oncologyDedifferentiated Liposarcoma of the Right Colon.
Digestive diseases and sciencesMolecular and Immune Mechanisms Governing Cancer Metastasis, Including Dormancy, Microenvironmental Niches, and Tumor-Specific Programs.
International journal of molecular sciencesDedifferentiated Liposarcoma With Low-Grade Osteosarcomatous Differentiation: A Rare Case With Long-Term Imaging Follow-Up.
Cureus[Scrotal tumour with growth to the retroperitoneum and the kidney].
Ugeskrift for laegerSubtype-specific characteristics and outcomes of liposarcoma: A population-based study using Japan's National Cancer Registry.
Journal of orthopaedic science : official journal of the Japanese Orthopaedic AssociationBiallelic NF1 Inactivation and Widespread Loss of Heterozygosity in a Subset of Unclassified Fibromyxoid Mesenchymal Neoplasms.
Genes, chromosomes & cancerA Japanese Multicenter Database Study of Retroperitoneal Sarcoma: Outcomes of Patients Receiving Eribulin Therapy.
Asia-Pacific journal of clinical oncologyEpigenetic dysregulation of metabolic programs mediates liposarcoma cell plasticity.
Science translational medicineReal-World Implementation of Next-Generation Sequencing in Sarcoma: Molecular Insights and Therapeutic Outcomes.
Medical sciences (Basel, Switzerland)Huge Intrathoracic Lipoma Occupying the Right Hemithorax.
Respirology case reportsMyxoid liposarcoma of right popliteal fossa: Case report and review.
Medicine[A Case of Symptomatic Giant Retroperitoneal Intramuscular Lipoma with Clinically Suspected Well-Differentiated Liposarcoma].
Gan to kagaku ryoho. Cancer & chemotherapy[A Transfusion-Free Surgery for a Jehovah's Witness Bearing a Large Retroperitoneal Liposarcoma with Marked Anemia by Adopting Patient Blood Management-Based Multidisciplinary Approach].
Gan to kagaku ryoho. Cancer & chemotherapy[Leiomyosarcoma Originating from the Renal Vein-A Case Report].
Gan to kagaku ryoho. Cancer & chemotherapyIntratendinous Lipoma of Biceps Long Head: A Case Report and Current Concepts Review of Musculoskeletal Lipomas.
Journal of orthopaedic case reportsA Huge Recurrent Atypical Lipomatous Tumor (Well-Differentiated Liposarcoma) going in to Dedifferentiation 12 years after its First Detection.
Journal of orthopaedic case reportsAcute sciatic nerve palsy secondary to postoperative seroma following soft tissue sarcoma resection: A case report.
International journal of surgery case reportsPathologic Assessment of Retroperitoneal Sarcomas: A Position Paper By the Transatlantic Australasian Retroperitoneal Sarcoma Working Group.
The American journal of surgical pathologyPleomorphic liposarcoma of the breast.
Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de Anatomia Patologica y de la Sociedad Espanola de CitologiaAtypical Spindle Cell Lipomatous Tumor: A Scoping Review of Current Insights Into Diagnosis, Pathogenesis, and Management.
CureusSynchronous Retroperitoneal Pleomorphic Liposarcoma and Colonic Mucinous Adenocarcinoma.
Case reports in oncologyCMLPS-N1: a novel preclinical cell line model for canine mammary tumor and its application in therapeutic screening.
The veterinary quarterlyGiant well-differentiated liposarcomas of the gluteal region: A case report.
MedicineMDM2 in Tumor Biology and Cancer Therapy: A Review of Current Clinical Trials.
International journal of molecular sciencesTargeting Glutamine Transporters as a Novel Drug Therapy for Synovial Sarcoma.
CancersKNTC1 and PRC1 define an immunosuppressive microenvironment and poor prognosis in liposarcoma.
European journal of medical researchCan multi-phase contrast-enhanced CT be used to differentiate between intra-abdominal and retroperitoneal fat-poor liposarcoma and leiomyosarcoma?
BMC medical imagingRetroperitoneal Dedifferentiated Liposarcoma With Penetrating Abscess Formation Secondary to Ileal Invasion: A Case Report.
Clinical case reportsVascular Reconstruction in Extremity Soft Tissue Sarcomas: A Systematic Review and Single-Arm Meta-Analysis.
Journal of surgical oncologyAtypical Spindle Cell/Pleomorphic Lipomatous Tumour (AS/PLT) - An Emerging Entity Diagnosed on Fine Needle Aspiration Cytology.
Cytopathology : official journal of the British Society for Clinical CytologyWhole-body MRI for staging and follow-up of primary musculoskeletal tumours: a systematic review.
The British journal of radiology[Liposarcoma of the thyroid gland?].
Pathologie (Heidelberg, Germany)Lipoblastoma of the chest wall: a case report of successful management of a rare cause of benign chest wall swelling.
Annals of medicine and surgery (2012)Adult urologic sarcomas: a single institution experience over 25 years.
The Canadian journal of urologyMadelung Disease of the Scrotal Region: A Case Report.
IJU case reports[Clinicopathological and molecular genetic analysis of orbital liposarcoma].
Zhonghua bing li xue za zhi = Chinese journal of pathologyRetroperitoneal multiple giant liposarcoma: a case report.
Frontiers in surgeryMyxoid Pleomorphic Liposarcoma: A Review and Update.
Cancer genomics & proteomicsCHAMP1 complex promotes heterochromatin assembly and reduces replication stress.
Proceedings of the National Academy of Sciences of the United States of AmericaEsophageal fistula after resection of giant mediastinal liposarcoma: A case report.
World journal of clinical casesAn evaluation of afamitresgene autoleucel for the treatment of advanced synovial sarcoma and myxoid round cell liposarcoma.
Expert review of anticancer therapyHigh Immunohistochemical Expression of SETD5 as a Candidate Pathological Factor for Dedifferentiation and Prognosis in Liposarcoma.
Pathology internationalRetroperitoneal hibernoma mimicking a metastatic germ cell tumor: a case report and review of the literature.
Journal of medical case reportsDesign and biological evaluation of novel water-soluble complexes based on thiosemicarbazone as prospective anticancer agents.
Scientific reportsRetroperitoneal dedifferentiated liposarcoma with colon infiltration: a case report and literature review.
Frontiers in oncologyPrimary dedifferentiated liposarcoma of the ovary: expanding the surgical management spectrum with a different resection extent than existing reports - a case report and literature review.
Frontiers in oncologyApplying Radiomics to Predict Outcomes in Patients with High-Grade Retroperitoneal Sarcoma Treated with Preoperative Radiotherapy.
Journal of imaging[The physiological function of PPARγ and its research progress in retroperitoneal soft tissue sarcomas].
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunologyAtypical lipomatous tumor/well-differentiated liposarcoma in the subcostal space of the chest wall: a case report and review of the literature.
Journal of cardiothoracic surgeryThe Role of RB1 and Secondary Genomic Changes in the Development of Spindle Cell and Pleomorphic Lipomas.
Genes, chromosomes & cancerA 3D bioprinted liposarcoma tumor microenvironment model recapitulates stroma-driven invasion and chemoresistance.
Journal of materials chemistry. BEribulin and sintilimab combined with radiotherapy in a heavily pretreated patient with advanced retroperitoneal myxoid pleomorphic liposarcoma: a case report and literature review.
Frontiers in oncologyPredicting GD2 expression across cancer types by the integration of pathway topology and transcriptome data.
Frontiers in bioinformaticsAccuracy of Histology and Malignancy Grade between Preoperative Biopsy and Surgical Specimens in Primary Retroperitoneal Sarcoma. A Study from the Prospective Retroperitoneal Sarcoma Registry (Resar).
Annals of surgeryMRI-based deep learning and radiomics pipeline for myxoid liposarcoma: a feasibility study in a rare sarcoma.
Scientific reportsPseudoneoplastic Fat Atrophy of Intra-Abdominal Sites: A Clinicopathologic Study of 16 Cases Representing a Potential Diagnostic Pitfall.
The American journal of surgical pathologyRECIST Responses to Radiation in Retroperitoneal Soft Tissue Sarcoma: When and How Often Do They Occur?
The Journal of surgical researchA case of liposarcoma derived from fatty tissue around the inferior mesenteric artery resected by combined aortic resection.
International cancer conference journalDiagnostic potential of a novel immunohistochemical marker, GFPT2, in differentiating mesothelioma from its morphological mimics.
HistopathologyExpanding the Morphologic and Molecular Spectrum of Spindle Cell Tumors Associated With TERT Fusions.
Genes, chromosomes & cancerA giant retroperitoneal liposarcoma encasing vital organs: A case report.
JPMA. The Journal of the Pakistan Medical AssociationGelatin-Based Soft-Tissue Sarcoma Organoids Recapitulate Patient Tumor Characteristics.
Biomaterials researchWhat is the utility of whole-body PET/MRI in the staging of myxoid liposarcoma?
Skeletal radiologyA Rare Lower Extremity Intramuscular Lipoma With Heterotopic Ossification.
Case reports in orthopedicsPerinephric myxoid tumour of fat and IgG4-related disease: when retroperitoneal fat conceals two truths. A case report of a tricky diagnosis.
BJR case reportsTrabectedin-olaparib combination or trabectedin in advanced soft tissue sarcomas after failure of anthracycline-based treatment (TOMAS2): a randomized phase II study from the Italian Sarcoma Group.
Annals of oncology : official journal of the European Society for Medical OncologyClinically significant delayed gastric emptying after multivisceral resection for retroperitoneal sarcoma: A retrospective cohort study.
Surgical oncologyCommentary: Case Report: a giant liposarcoma of the spermatic cord.
Frontiers in oncologyATRX loss in sarcomas is associated with dysregulated gene and transposable element expression, loss of DNA methylation, and worse survival.
medRxiv : the preprint server for health sciencesTumor and Immune Dynamics Following Sequential CDK4/6 and PD-1 Inhibition: Results from a Phase 2 Study in Dedifferentiated Liposarcoma.
Cancer research communicationsIncidental Hibernoma With an Atypical Presentation: Diagnostic Approach, Pathologic Correlation, and Lessons Learned.
CureusParatesticular liposarcomas: A rare but crucial diagnosis. Case series and review of literature.
Central European journal of urologyPathological complete response to pembrolizumab in recurrent retroperitoneal dedifferentiated liposarcoma with high tumor mutational burden: a case report.
World journal of surgical oncologyPrognosis of dedifferentiated liposarcoma based on surveillance, epidemiology, and end results database.
European journal of medical researchCytological Features of Spindle Cell Lesions of the Head and Neck and Review of the Literature.
Acta cytologicaClinicopathological Characteristics and Survival Analysis of Primary Mesenteric Liposarcoma: A Retrospective Study.
Medicina (Kaunas, Lithuania)SOX9, GATA3, and GATA4 Overexpression in Liposarcomas: Insights into the Molecular Biology of Adipocytic Sarcomas.
International journal of molecular sciencesDehydroascorbic Acid Induces Cell Death in Sarcoma Stem Cells Under bFGF-Mediated Stemness-Supporting Conditions.
Antioxidants (Basel, Switzerland)Clinicopathological Implications of Maspin, CD8, and PD-L1 Expression in Liposarcomas.
Current issues in molecular biologyMarginal Excision of Atypical Lipoma of the Forearm.
Annals of African medicineDistinct Sarcoma Microenvironments Predict Benefit from Addition of Pembrolizumab to Preoperative Radiotherapy and Surgery in SU2C-SARC032.
medRxiv : the preprint server for health sciencesRefining surveillance in Myxoid liposarcoma: long-term recurrence patterns and functional outcomes after surgery ± radiotherapy in 186 patients.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and OncologyCriteria for MDM2 fluorescence in situ hybridization testing in the diagnosis of well-differentiated adipocytic neoplasms: a retrospective utilization review of 1151 cases.
Virchows Archiv : an international journal of pathologyExtracellular Vesicles in Sarcoma: Implications for Tumor Progression and Therapy.
International journal of nanomedicine[Giant Mediastinal Liposarcoma Resected via Clamshell Thoracotomy Combined with Lower Partial Sternotomy].
Kyobu geka. The Japanese journal of thoracic surgeryIntegrating machine learning and molecular dynamics simulation to decipher the molecular network of dioxin-associated liposarcoma.
Scientific reportsLipoblastoma-Like Tumor: A Case Report From Costa Rica.
CureusPrimary hemangioblastoma of rectum: a rare case report and review of literature.
Journal of cancer research and clinical oncologyDevelopment and validation of a multiphase computed tomography-based radiomics classifier for differentiating retroperitoneal non-fatty dedifferentiated liposarcoma from leiomyosarcoma.
Abdominal radiology (New York)Imaging Findings of Atypical Spindle Cell/Pleomorphic Lipomatous Tumors: A Case Series and Systematic Review.
CureusCharacteristic magnetic resonance imaging features of atypical spindle cell/pleomorphic lipomatous tumor.
Quantitative imaging in medicine and surgeryLiposarcoma and Leiomyosarcoma as the First Manifestation of Familial Retinoblastoma: Implications for Genetic Testing and Carrier Surveillance.
JCO precision oncologyDeveloping a diagnostic model to differentiate the well-differentiated lipomatous tumors based on clinicopathological characteristics.
Scientific reportsImpact of surgical margins on recurrence after resection of atypical lipomatous tumors: A single-center retrospective analysis.
SurgeryLiposarcoma Arising From Mature Teratoma Following Testicular Tumor Surgery: A Case Report.
IJU case reportsA rare case report: retroperitoneal dedifferentiated liposarcoma associated with paraneoplastic pemphigus.
Frontiers in surgeryCase Report: Diagnosis and treatment of giant thoracodorsal liposarcoma.
Frontiers in oncologyPancreaticoduodenectomy and IVC resection in retroperitoneal sarcoma: Expanding the limits of feasible surgery.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyIncidence and prognostic impact of regional lymph node metastasis at the time of diagnosis in soft-tissue sarcoma : a population-based cohort study.
The bone & joint journalMRI-based radiomic analysis for grading myxoid liposarcoma: a multisequence retrospective study.
Skeletal radiologyOrthopedic Surgical Management of Soft Tissue Sarcomas in a Referral Center: 5-Year Oncological Outcomes.
Orthopaedics & traumatology, surgery & research : OTSRSpectrum and Clinical Impact of Secondary Genetic Alterations in Translocation-Associated Sarcomas.
JCO precision oncology[One case of hypopharyngeal dedifferentiated liposarcoma].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgeryGiant retroperitoneal lipoma in 62-year-old male: a rare benign tumor in an unusual location.
Journal of surgical case reportsCase report and diagnostic implications of misdiagnosis of pericardial myxoid liposarcoma by multimodal imaging.
Frontiers in cardiovascular medicineWell-Differentiated Spindle Cell Liposarcoma of the Larynx in a Patient With a History of a Benign Laryngeal Lesion: A Case Report.
CureusImaging of the Retroperitoneum.
Radiologic clinics of North AmericaDiagnostic Complexity of Spermatic Cord Liposarcoma: A Report of Two Cases.
CureusPrimary Localized Peritoneal Malignant Mesothelioma Involving the Stomach and Transverse Colon: A Case Report.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chiCorrigendum to "Aged mice overexpressing cellular repressor of E1A-stimulated genes 1 in adipose tissues exhibited increased liposarcoma incidence and shortened lifespan" [Biochem. Biophys. Res. Commun. 753 (2025) 151454].
Biochemical and biophysical research communicationsCT-based radiomics nomogram for differentiating dedifferentiated liposarcoma from well-differentiated liposarcoma.
Frontiers in oncologyNeo-inguinal reconstruction: algorithm for layered vascularized tissue coverage using plug flap following oncologic inguinal resection.
Hernia : the journal of hernias and abdominal wall surgeryAnaplastic thyroid carcinoma with liposarcomatous foci: a novel heterologous differentiation.
HistopathologyUnexpected Paraganglioma Identified During Bilateral Nephrectomy in Autosomal Dominant Polycystic Kidney Disease: A Case Report.
CureusNovel SMARCA2::DDIT3 Fusion in Primary Subcutaneous Myxoid Liposarcoma due to an Unusual Unbalanced Chromosomal Translocation.
Genes, chromosomes & cancerARNT2-driven transcriptional activation of STRA6 reprograms fatty acid metabolism to promote retroperitoneal liposarcoma progression.
Journal of cancer research and clinical oncologyGiant dedifferentiated liposarcoma of the mandible.
International journal of oral and maxillofacial surgeryAirway obstruction caused by functional failure of a tracheal stent.
Anaesthesia reportsOutcomes in patients with abdominal soft tissue sarcoma: a retrospective cohort study from a single Swiss tertiary referral centre.
Swiss medical weeklyA Rare Case of Giant Retroperitoneal Dedifferentiated Liposarcoma: A Case Report.
CureusSintilimab-related fulminant autoimmune diabetes mellitus manifesting as diabetic ketoacidosis and rare insulin resistance: A case report and literature review.
Endocrine journalSuccinate Dehydrogenase B (SDHB) Overexpression with Enzymatic Dysfunction Defines a Distinct Subtype of Undifferentiated Pleomorphic Sarcoma.
Cancer research communicationsGPX1 expression promotes stemness and aggressiveness in myxoid liposarcomas.
International journal of biological sciencesEnd-to-end deep learning model for the diagnosis and segmentation of primary retroperitoneal neoplasm: a multicenter cohort study.
EClinicalMedicineAn onco-vascular surgical approach: Internal iliac artery transposition for external iliac artery repair during cytoreductive surgery.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyThe prognostic potential of circulating biomarkers for sarcoma patients with pleural dissemination.
Pathology oncology research : PORManganese-based nanotheranostics synergizing photothermal-chemotherapy for liposarcoma treatment.
RSC advancesRecycled Skin Grafting for Reconstruction Following Wide Local Excision of Liposarcoma.
The Journal of dermatologyAdvancing human leukocyte antigen-based cancer immunotherapy: from personalized to broad-spectrum strategies for genetically heterogeneous populations.
Trends in cancerIdentification of Guanine-Quadruplex-Binding Peptides from the RGG3 Domain of TLS/FUS.
Chemical & pharmaceutical bulletinSinonasal Sarcomas Management: An International Consensus Statement.
International forum of allergy & rhinologyThe Role of FAPI-PET in Evaluating Suspected Liposarcoma: A Case on the Diagnostic Potential.
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der NuklearmedizinImpact of vacuum assisted wound therapy on wound complications in STS surgery- A 3-year retrospective single-centre analysis.
Langenbeck's archives of surgeryHistologic Subvariants of Retroperitoneal Well-Differentiated Liposarcoma Show Evidence of Clinical and Genomic Progression Toward Dedifferentiated Liposarcoma.
JCO precision oncologyFET fusion oncoproteins enrich SWI/SNF complex subtypes and interaction partners.
Cellular & molecular biology lettersCharacteristics and Outcomes of Soft Tissue Sarcoma in Saudi Arabia: A 10-Year Experience.
Cancer management and researchSurgical resection of a giant retroperitoneal dedifferentiated liposarcoma: a case report.
Frontiers in surgeryWhen Cancer Erupts: Recognizing the Volcano Lesion in Gastric Metastases.
ACG case reports journalMaintenance after first-line treatment for advanced soft tissue sarcoma.
Critical reviews in oncology/hematologyAssociações
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Doença com base genética
Um médico geneticista pode ajudar no diagnóstico de Lipossarcoma e no aconselhamento genético da família.
Doenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Perguntas frequentes
O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu
É um tipo de câncer maligno que se forma a partir de células do tecido adiposo do organismo. Pode variar de tumores bem diferenciados até formas pleomórficas e desdiferenciadas, com diferentes potenciais de disseminação.
Referências
Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete
10 publicações do grafo RarasNet (PubMed) · 7 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Citar este verbete
Raras. (s.d.). Lipossarcoma. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/lipossarcoma
Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
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Lipossarcoma
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Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.
- Doença rara (ontologia)
- fonte: Orphanet
- Identificador unificado
- fonte: MONDO
- Codificação WHO/SUS
- fonte: WHO ICD-10 / DATASUS
- CID-11 (futuro)
- fonte: WHO ICD-11
- NIH/GARD
- fonte: GARD (NIH)
- Indexação biomédica
- fonte: MeSH (NLM)
- Dado público estruturado
- fonte: Wikidata
- Medicamentos aprovados FDA
- fonte: FDA OpenFDA
- Ensaios clínicos
- fonte: ClinicalTrials.gov
