Um câncer que surge do tecido muscular, da gordura, dos vasos sanguíneos, do tecido fibroso ou de outros tecidos de suporte, com exceção dos ossos.
Introdução
O que você precisa saber de cara
O sarcoma de tecidos moles é um tipo de câncer que se origina nos tecidos de sustentação do organismo, como músculos, gordura e vasos sanguíneos, excetuando os ossos. A pessoa pode notar alterações na musculatura, inchaços, perda de peso expressiva e comprometimento de órgãos internos. No cenário internacional, medicamentos como doxorrubicina e pazopanibe foram aprovados por órgãos regulatórios como o FDA americano. No Brasil, a patologia não possui um Protocolo Clínico e Diretrizes Terapêuticas (PCDT) próprio na lista de doenças raras do SUS, devendo o paciente buscar avaliação na rede especializada de saúde.
Um câncer que surge do tecido muscular, da gordura, dos vasos sanguíneos, do tecido fibroso ou de outros tecidos de suporte, com exceção dos ossos.
Tem tratamento?
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 46 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 103 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
41 genes identificados com associação a esta condição.
Rhabdomyosarcoma 2
A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas.
Ewing sarcoma
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Melanoma, cutaneous malignant 3
A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but may also involve other sites.
Rhabdoid tumor predisposition syndrome 2
A familial cancer syndrome predisposing to renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors. Rhabdoid tumors are the most aggressive and lethal malignancies occurring in early childhood.
Silver-Russell syndrome 5
A form of Silver-Russell syndrome, a clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age. SRS5 inheritance is autosomal dominant.
Frasier syndrome
Characterized by a slowly progressing nephropathy leading to renal failure in adolescence or early adulthood, male pseudohermaphroditism, and no Wilms tumor. As for histological findings of the kidneys, focal glomerular sclerosis is often observed. There is phenotypic overlap with Denys-Drash syndrome. Inheritance is autosomal dominant.
Basal ganglia calcification, idiopathic, 5
A form of basal ganglia calcification, an autosomal dominant condition characterized by symmetric calcification in the basal ganglia and other brain regions. Affected individuals can either be asymptomatic or show a wide spectrum of neuropsychiatric symptoms, including parkinsonism, dystonia, tremor, ataxia, dementia, psychosis, seizures, and chronic headache. Serum levels of calcium, phosphate, alkaline phosphatase and parathyroid hormone are normal. The neuropathological hallmark of the disease is vascular and pericapillary calcification, mainly of calcium phosphate, in the affected brain areas.
Caffey disease
An autosomal dominant disorder characterized by an infantile episode of massive subperiosteal new bone formation that typically involves the diaphyses of the long bones, mandible, and clavicles. The involved bones may also appear inflamed, with painful swelling and systemic fever often accompanying the illness. The bone changes usually begin before 5 months of age and resolve before 2 years of age.
Craniosynostosis 3
A primary abnormality of skull growth involving premature fusion of one or more cranial sutures. The growth velocity of the skull often cannot match that of the developing brain resulting in an abnormal head shape and, in some cases, increased intracranial pressure, which must be treated promptly to avoid permanent neurodevelopmental disability.
Osteogenesis imperfecta 16
An autosomal recessive form of osteogenesis imperfecta, a disorder of bone formation characterized by low bone mass, bone fragility and susceptibility to fractures after minimal trauma. Disease severity ranges from very mild forms without fractures to intrauterine fractures and perinatal lethality. Extraskeletal manifestations, which affect a variable number of patients, are dentinogenesis imperfecta, hearing loss, and blue sclerae. OI16 is a severe form.
Microphthalmia, syndromic, 2
A very rare multiple congenital anomaly syndrome characterized by eye anomalies (congenital cataract, microphthalmia, or secondary glaucoma), facial abnormalities (long narrow face, high nasal bridge, pointed nose with cartilages separated at the tip, cleft palate, or submucous cleft palate), cardiac anomalies (atrial septal defect, ventricular septal defect, or floppy mitral valve) and dental abnormalities (canine radiculomegaly, delayed dentition, oligodontia, persistent primary teeth, or variable root length). Microphthalmia is a disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities.
Intellectual developmental disorder, X-linked, syndromic, with pigmentary mosaicism and coarse facies
A disorder characterized by severe developmental delay with impaired intellectual development and poor speech, coarse facial dysmorphisms, and Blaschkoid pigmentary mosaicism. Additional clinical features may include epilepsy, orthopedic abnormalities, hypotonia, and growth abnormalities. The disorder affects both males and females.
Ewing sarcoma
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Ewing sarcoma
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Neurofibromatosis 1
A disease characterized by patches of skin pigmentation (cafe-au-lait spots), Lisch nodules of the iris, tumors in the peripheral nervous system and fibromatous skin tumors. Individuals with the disorder have increased susceptibility to the development of benign and malignant tumors.
Ewing sarcoma
A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors.
Waardenburg syndrome 1
WS1 is an autosomal dominant disorder characterized by non-progressive sensorineural deafness, pigmentary disturbances such as frontal white blaze of hair, heterochromia of irides, white eyelashes, leukoderma, and wide bridge of nose owing to lateral displacement of the inner canthus of each eye (dystopia canthorum). WS1 shows variable clinical expression and some affected individuals do not manifest hearing impairment or iris pigmentation disturbances. Dystopia canthorum is the most consistent sign and is found in 98% of the patients.
Lung cancer
A common malignancy affecting tissues of the lung. The most common form of lung cancer is non-small cell lung cancer (NSCLC) that can be divided into 3 major histologic subtypes: squamous cell carcinoma, adenocarcinoma, and large cell lung cancer. NSCLC is often diagnosed at an advanced stage and has a poor prognosis.
Pleuropulmonary blastoma
A rare pediatric intrathoracic neoplasm. The tumor arises from the lung, pleura, or both, and appears to be purely mesenchymal in phenotype. It lacks malignant epithelial elements, a feature that distinguishes it from the classic adult-type pulmonary blastoma. It arises during fetal lung development and is often part of an inherited cancer syndrome. The tumor contain both epithelial and mesenchymal cells. Early in tumorigenesis, cysts form in lung airspaces, and these cysts are lined with benign-appearing epithelium. Mesenchymal cells susceptible to malignant transformation reside within the cyst walls and form a dense layer beneath the epithelial lining. In a subset of patients, overgrowth of the mesenchymal cells produces a sarcoma, a transition that is associated with a poorer prognosis. Some patients have multilocular cystic nephroma, a benign kidney tumor.
Rhabdomyosarcoma 2
A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas.
Spermatogenic failure, X-linked, 5
A male infertility disorder characterized by reduced progressive sperm motility and multiple morphologic sperm abnormalities, resulting in asthenoteratozoospermia.
Rhabdoid tumor predisposition syndrome 1
A familial cancer syndrome predisposing to renal or extrarenal malignant rhabdoid tumors and to a variety of tumors of the central nervous system, including choroid plexus carcinoma, medulloblastoma, and central primitive neuroectodermal tumors. Rhabdoid tumors are the most aggressive and lethal malignancies occurring in early childhood.
Medicamentos aprovados (FDA)
2 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
186 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 1 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
195 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Sarcoma de tecidos moles
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 6.427
Alveolar Soft Part Sarcoma in Pediatric and Young Adult Patients: A Report From the Children's Oncology Group Study ARST0332.
Alveolar soft part sarcoma (ASPS) is a rare soft tissue sarcoma occurring most commonly in adolescence and young adulthood. We present the clinical characteristics, treatments, and outcomes of patients with newly diagnosed ASPS enrolled on the Children's Oncology Group study ARST0332. Patients were treated with risk-adapted therapy, including surgery with or without radiotherapy and ifosfamide and doxorubicin. Twenty-four patients with ASPS enrolled on ARST0332 between 2007 and 2012 were analyzed. The majority of primaries were extremity tumors (71%) and > 5 cm (54%). Nearly half (46%) of patients had metastatic disease at diagnosis, all of whom had primary tumors > 5 cm and pulmonary metastases with or without extrapulmonary metastases. Six patients were evaluable for response to neoadjuvant chemoradiotherapy without an objective response. Estimated 5-year event-free survival (EFS) and overall survival (OS) were 91% and 100% for low-risk (n = 11), 0% and 50% for intermediate-risk (n = 2), and 0% and 59% for high-risk disease (n = 11), respectively. EFS and OS differed significantly by maximal tumor diameter, presence or absence of metastatic disease, risk group, treatment arm, and upfront primary site resection status. Patients with low-risk ASPS (non-metastatic, grossly resected tumors ≤ 5 cm) had excellent outcomes with surgery with or without radiation on ARST0332. Chemotherapy has been reported to be generally ineffective in ASPS and, indeed, there were no objective responses to neoadjuvant chemoradiotherapy on ARST0332. All patients treated with combination chemoradiotherapy ultimately developed disease progression/relapse. A different therapeutic approach is needed for patients with unresectable or metastatic ASPS.
Local Control of Bladder/Prostate Rhabdomyosarcoma: An Expert Consensus Guideline From the International Soft Tissue Sarcoma Consortium (INSTRuCT).
The local treatment of bladder and prostate rhabdomyosarcoma is a multidisciplinary decision, incorporating elements of patient age, tumor size and location, nodal involvement, and access to local expertise and technology. The relative absence of long-term bladder and bowel function outcome data complicates discussions, particularly given improved survival rates and development of new surgical and radiotherapy techniques. These INSTRuCT guidelines, a collaboration of the Children's Oncology Group, Soft Tissue Sarcoma Committee, European Pediatric Soft Tissue Sarcoma Study Group, and the Cooperative Weichteilsarkom Studiengruppe, reflect international expert consensus and are intended to inform practice, generate discussion, and highlight areas of future inquiry.
VCAN Is Essential for ERK5-Driven Tumorigenesis in Soft Tissue Sarcoma.
The ERK5 signaling pathway has recently emerged as a critical regulator of soft tissue sarcoma (STS) biology, contributing to tumor initiation, progression, and maintenance. In this study, we identify VCAN, a chondroitin sulfate proteoglycan, as a novel transcriptional target of ERK5 and a central mediator of ERK5-related oncogenesis. Through a combination of genetic (silencing, overexpression) and pharmacological approaches, applied in both a chemically induced murine sarcoma model and several human STS cell lines, we demonstrate that ERK5 positively regulates VCAN expression. Functionally, VCAN silencing (by shRNAs) recapitulates the phenotypes of ERK5 silencing, including impaired migration, adhesion, proliferation, and tumorigenesis. Conversely, VCAN overexpression rescues these effects, confirming its essential role in ERK5-mediated oncogenesis. Furthermore, transcriptomic profiling reveals that VCAN accounts for a substantial portion of ERK5-regulated gene expression program. Analyses of human STS patient samples reveal significantly elevated mRNA levels of both VCAN and ERK5 compared to normal tissues. Notably, a strong correlation between VCAN and ERK5 expression, both at mRNA and protein levels, emerged in biopsies from leiomyosarcomas and undifferentiated pleomorphic sarcomas. Together, these findings uncover VCAN as a key effector in ERK5-driven tumorigenesis and highlight the ERK5/VCAN signaling axis as a promising therapeutic target in soft tissue sarcomas.
A Phase 1 Study of Neoadjuvant Cabozantinib in Combination With Radiation Therapy for Sarcomas of the Extremities.
Cabozantinib demonstrates activity in multiple soft tissue sarcoma (STS) subtypes, but use with concurrent radiation therapy (RT) has been limited by concern for risk of fistula or perforation. This phase 1 trial evaluated the safety of concurrent cabozantinib and RT as neoadjuvant therapy in patients with extremity STS. Adults with newly diagnosed localized extremity STS planned for neoadjuvant RT and surgical resection were eligible. Participants received radiation with 5000 to 5040 cGy with conventional fractionation and cabozantinib 40 mg or 60 mg daily. Patients were observed for dose-limiting toxicity (DLT) up to 28 days after completion of concurrent cabozantinib/RT. The primary objective was to identify a recommended phase 2 dose (RP2D) of cabozantinib for combination with RT, and secondary objectives included estimating rates of treatment-related adverse event (TRAE), margin positivity, and objective response. Six patients were enrolled with histologic subtypes of undifferentiated pleomorphic sarcoma, myxofibrosarcoma, leiomyosarcoma, and myxoid liposarcoma. No DLT due to the combination of cabozantinib and radiation was observed, but 3/6 (50%) patients required dose-reduction due to TRAE of cabozantinib alone. No grade ≥3 toxicities were attributed to RT. The RP2D was cabozantinib 60 mg. Six (100%) patients demonstrated stable disease at 12 weeks, and 5 (83%) underwent R0 resection. Two (33%) patients experienced metastatic relapse, and 1 (17%) died without relapse; 3 (50%) patients survived without relapse by last contact. No local recurrences occurred. In this phase 1 trial, concurrent cabozantinib/RT was feasible and demonstrated an acceptable safety profile for patients with extremity STS.
From bench to bedside: combining HDAC inhibitors with standard therapies in rhabdomyosarcoma treatment.
Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma in children, and despite advances in multimodal therapy, progress in improving the survival of high-risk patients has been limited. Increasing evidence indicates that epigenetic dysregulation contributes to RMS pathogenesis and therapeutic resistance, particularly through aberrant activity of histone deacetylases (HDACs). HDAC inhibitors (HDACi) have shown promise in preclinical RMS models, showing enhancing of the efficacy of standard chemotherapies and radiotherapy. This mini-review summarizes recent studies exploring HDAC inhibition in combination with first-line therapies, examines the mechanistic basis for therapeutic synergy, and discusses opportunities and challenges in translating HDACi-based combinations to the clinic. By integrating mechanistic insights with translational evidence, this review outlines current progress and proposes future directions for development of HDACi-enhanced treatment strategies for this aggressive pediatric malignancy.
Publicações recentes
EXPRESS: Feline tarsal tumors: histologic spectrum, risk factors, and prognostic insights.
ATRX loss in sarcomas is associated with dysregulated gene and transposable element expression, loss of DNA methylation, and worse survival.
Prognostic impact of tumour-vessel proximity in soft tissue sarcoma: Fujiwara classification provides enhanced risk stratification.
Trabectedin and low-dose irinotecan to target EWS::FLI1 in Ewing sarcoma: a phase 1/2 trial.
Liposomal Versus Conventional Doxorubicin as First-Line Therapy in Advanced Soft Tissue Sarcomas: Observational Multi-Institutional Cohort of 8.5-Year Experience.
📚 EuropePMC4.685 artigos no totalmostrando 197
Collision Tumor of Metastatic Lung Adenocarcinoma to Lower Limb Leiomyosarcoma: Case Report and Literature Review.
International journal of surgical pathologySuperficial Rhabdomyosarcomas: A Review of Subtypes, Diagnostic Features, and Differential Diagnoses.
International journal of surgical pathologyImmune cell clustering identifies a CD163⁺/CSF1R⁺ macrophage and neutrophil-enriched phenotype with distinct biological signatures and poor prognosis in angiosarcoma.
OncoimmunologyDistinct immunologic patterns of response and resistance to anti-PD-1/PD-L1-based immunotherapy in patients with soft tissue sarcoma.
Frontiers in immunologyAxial Round Cell Sarcoma Harboring a Non-ETS EWSR1 Rearrangement: Diagnostic Challenges and Clinical Implications.
CureusThe effect of neoadjuvant radiotherapy on immune cell infiltrates in myxofibrosarcoma.
Immuno-oncology technologyCervical embryonal rhabdomyosarcoma beyond childhood: A case report and literature review.
Radiology case reportsProphylactic Lymphedema Surgery During Soft Tissue Sarcoma Resection: Surgical Technique Step by Step.
Plastic and reconstructive surgery. Global openAnthropometric factors, physical activity, and the risk of soft tissue sarcoma: a case-control study.
European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)Reduced initial Pazopanib dosing strategy for recurrent, advanced, or metastatic sarcoma: A single center experience.
Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy PractitionersPeritoneal Sarcomatosis Secondary to Conventional Chondrosarcoma: A Case Report.
CureusPerforator versus traditional flaps in extremity soft-tissue sarcoma reconstruction: A comparative cohort study.
Journal of plastic, reconstructive & aesthetic surgery : JPRASRevisiting the Immune Frontier in Soft Tissue Sarcomas.
Current oncology reportsEfficacy of Ultrasonic Scalpel in Orthopaedic Oncology Surgery: An Initial Patient Cohort Study Based on Propensity Score Matching Analysis.
The Journal of the American Academy of Orthopaedic SurgeonsAlveolar Soft Part Sarcoma in Pediatric and Young Adult Patients: A Report From the Children's Oncology Group Study ARST0332.
Pediatric blood & cancerRNA-binding Protein NMD3 Promotes Osteosarcoma Cell Proliferation Via Regulating mTOR Signaling Pathway, Exerting Adverse Impacts on Patient Prognosis.
Applied biochemistry and biotechnologyA rare presentation of uterine cavity embryonal rhabdomyosarcoma in a preschool girl: a case report.
International journal of surgery case reportsPrimary subcutaneous inguinal malignant melanoma mimicking a soft tissue sarcoma.
International journal of surgery case reportsComputed Tomography Features of Pulmonary Metastatic Nodules Help Narrow the Differential Diagnosis of the Primary Tumor.
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology AssociationIntramuscular Myxoma: Results from the Largest European Single-Center Study-Clinical and Pathological Findings and Syndromal Associations.
Diagnostics (Basel, Switzerland)The Extracellular Matrix Regulates Invasion in Fusion-Negative Rhabdomyosarcoma via YAP-PIEZO1 Signaling Axis.
CancersLow Survival Rates for Pediatric Patients with Tumor Thrombus in Sarcoma.
Journal of clinical medicinePredicting the Postoperative Recurrence Risk in Soft-Tissue Sarcomas of the Extremities and Trunk Using MRI-Based Nomogram.
Academic radiologyLocal Control of Bladder/Prostate Rhabdomyosarcoma: An Expert Consensus Guideline From the International Soft Tissue Sarcoma Consortium (INSTRuCT).
Pediatric blood & cancerPleomorphic rhabdomyosarcoma, outcomes of patients with advanced disease treated with systemic agents: Retrospective study from the global pushing ultra-rare sarcomas towards hope (PUSH) consortium.
European journal of cancer (Oxford, England : 1990)Tumor habitat characteristics derived from intravoxel incoherent motion for early response assessment in soft tissue sarcoma undergoing neoadjuvant radiotherapy and targeted therapy: a phase II study.
Translational cancer researchNeoadjuvant irradiation of extremity soft tissue sarcoma with ions (Extrem‑ion): Interim report of a randomized phase II pilot trial.
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and OncologyClinical Impact of Integrating RNA-Based Next-Generation Sequencing Into the Diagnostic Evaluation of Soft Tissue Sarcomas: Insights From a Single-Center Multidisciplinary Workflow.
JCO global oncologyUndifferentiated testicular pleomorphic sarcoma: A case report.
World journal of clinical casesComputed tomography-based nutritional associated nomogram on machine learning predicts survival outcomes in patients with resectable soft-tissue sarcoma.
World journal of radiologyTiming and Frequency of Surveillance After Resection of Extremity and Trunk Soft Tissue Sarcoma: Identifying Opportunities for Improvement.
Annals of surgical oncologyPatient perspectives on recovery and satisfaction after hemipelvectomy for pelvic tumors.
Surgical oncologyMachine learning and logistic regression in estimating survival in patients with high-malignant deep-seated soft tissue sarcomas: development and analysis based on a population-based retrospective cohort.
Acta orthopaedicaVCAN Is Essential for ERK5-Driven Tumorigenesis in Soft Tissue Sarcoma.
International journal of biological sciencesEndovascular Thrombectomy in a Patient with Acute Ischemic Stroke due to Tumor Emboli Associated with Cardiac Metastasis of Extraskeletal Myxoid Chondrosarcoma: A Case Report.
NMC case report journalConcurrent Monkeypox, HHV8, and Other Opportunistic Infections in a Human Immunodeficiency Virus Patient with Disseminated Kaposi Sarcoma: A Case Report.
Case reports in oncologyPerifascial Nodular Fasciitis Adjacent to the Tensor Fasciae Latae: Ultrasound and MRI Findings in a Rare Hip Presentation.
CureusA Rapidly Progressing Lower Extremity Soft Tissue Sarcoma in an Adolescent Patient.
CureusLaparoscopic Reconstructive Repair of Uterine and Rectal Prolapse with Posterior Perineal Hernia after Wide Resection of Soft-tissue Sarcoma of the Buttocks: A Case Report.
Gynecology and minimally invasive therapyEpithelioid Sarcoma of the Forearm in a 70-Year-Old Woman: A Case Report at a Referral Facility in Tanzania.
Clinical case reportsEffectiveness of interstitial brachytherapy in extremity sarcoma-treatment outcomes and current concepts.
Indian journal of cancerPreventing unplanned "whoops" sarcoma surgery: from technical pearls to early referral and network-level quality metrics.
Chinese clinical oncologyTumour localization and oncological outcomes in nonuterine leiomyosarcoma of the abdomen and pelvis.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyFOXM1 inhibitor, RCM‑1, enhances venetoclax mediated apoptosis through downregulation of ATP2B4 in rhabdomyosarcoma.
International journal of oncologyThe analysis of biodistribution and tumor uptake of [18F]AlF-FAPI-74 in patients with soft tissue sarcoma and gastro-intestinal tumors compared with [18F]FDG in a prospective, exploratory study.
EJNMMI reportsAssociation of surgical resection with survival in retroperitoneal leiomyosarcoma based on SEER propensity score matching and machine-learning models.
Scientific reportsNeoadjuvant BO-112 and hypofractionated radiation therapy with or without nivolumab in soft tissue sarcoma: preclinical and phase 1 results.
Cancer discoveryBreathless and Beyond: Anterior Mediastinal Malignant Peripheral Nerve Sheath Tumor as a Rare Neurofibromatosis Type 1 Manifestation.
Clinical case reportsPerformance of deep learning-based segmentation of soft tissue sarcoma by MRI sequence, tumor type and location.
Skeletal radiologyA Rapidly Growing Cervical Tumor in an Infant: Sarcoma with BCOR Gene Alterations.
International journal of surgical pathologyCytologic, Histologic, and Ultrastructural Findings of Spontaneous, Cutaneous Fibrosarcoma in a Koi.
Veterinary clinical pathologyIncreased Uptake of 68Ga-DOTA-IBA in Sclerosing Epithelioid Fibrosarcoma.
Clinical nuclear medicineDesmoplastic Small Round Blue Cell Tumor in a Young Adult Man: A Rare Case of Abdominal Sarcoma.
The American journal of case reportsA Phase 1 Study of Neoadjuvant Cabozantinib in Combination With Radiation Therapy for Sarcomas of the Extremities.
American journal of clinical oncologyAtypical bone lesion of the fifth metatarsal bone in an HIV-positive patient: A challenging radiologic-pathologic correlation of tuberculous osteomyelitis.
Radiology case reportsFrom bench to bedside: combining HDAC inhibitors with standard therapies in rhabdomyosarcoma treatment.
Frontiers in cell and developmental biologyCase Report: An uncommon germline variant of familial GISTs: broadening the landscape of inherited GIST syndromes.
Frontiers in oncologyTrabectedin decreases myeloid resistance to improve the efficacy of anti-PD1 immunotherapy and delay glioma malignant progression.
Molecular therapy. OncologyWhen AI joins the table: evaluating large language model performance in soft tissue sarcoma tumor board decisions.
Journal of cancer research and clinical oncologyTargeting tRNA-Arg-TCT-4-1 suppresses cancer cell growth and tumorigenesis.
bioRxiv : the preprint server for biologyRadiation synergizes with BET inhibition to stimulate durable, systemic anti-tumor immunity in murine cancer models.
bioRxiv : the preprint server for biologyComparative modes of chromatin engagement by PAX::FOXO1 fusions in rhabdomyosarcoma.
bioRxiv : the preprint server for biologyBioinformatic Analysis to Identify Biomarker Candidates of Complex Karyotype Soft Tissue Sarcomas with CDK4-Amplification.
Biomolecules & therapeuticsA series of extraskeletal myxoid chondrosarcomas with rare morphological and molecular variations.
HistopathologyManagement of Great Saphenous Vein and Inferior Vena Cava Leiomyosarcomas: Two Surgical Case Reports and Literature Review.
Journal of clinical medicineClinical Characteristics of Complex Karyotype Soft Tissue Sarcomas: A Single-Institution Cohort Study.
Medicina (Kaunas, Lithuania)Tyrosine-Peptide Analog Modulates Extracellular Vesicles miRNAs Cargo from Mesenchymal Stem/Stromal and Cancer Cells to Drive Immunoregeneration and Tumor Suppression.
BiomoleculesCanine peritoneal and pleural larval mesocestoidosis with sarcoma development.
Veterinary parasitology, regional studies and reportsDermatofibrosarcoma protuberans: A clinical review of diagnosis and management.
Journal of the American Academy of DermatologySuperficial Tumor Location and Adiposity as Independent Predictors of Postoperative Wound Complications in Sarcoma Resections of the Thigh.
Journal of surgical oncology[Particle radiotherapy for sarcomas : Advantages, challenges and future perspectives].
Radiologie (Heidelberg, Germany)Trabectedin in the treatment of soft tissue sarcoma: Real-world data on effectiveness, safety, and financial implications from a European comprehensive cancer center.
International journal of cancerMolecular epidemiology of the expression of urokinase plasminogen activator receptor-associated protein (uPARAP) in mesenchymal malignancies.
Translational oncologyPrognostic determinants and survival outcomes in epithelioid sarcoma: A contemporary population-based analysis of 1123 patients.
MedicineComprehensive genomic profiling refines diagnosis and reveals clinically relevant alterations in pediatric Soft tissue sarcomas.
European journal of medical researchAn Atypical Presentation of Cutaneous Angiosarcoma: A Diagnostic Challenge in an End-Stage Renal Disease Patient.
CureusChildren and Young People With First Relapse or Progression of Upfront Metastatic Rhabdomyosarcoma: An Analysis of Clinical Features and Outcomes From the INternational Soft Tissue saRcoma ConsorTium (INSTRuCT).
Cancer medicinePercutaneous Cryoablation for the Management of Bone and Soft Tissue Tumors.
Seminars in musculoskeletal radiologyThe impact of non-centralised surgical treatment on local recurrence, amputation rate and survival in patients with extremity soft tissue sarcoma.
European journal of orthopaedic surgery & traumatology : orthopedie traumatologieTrabectedin plus CD13-targeted tissue factor tTF-NGR against advanced relapsed or refractory soft tissue sarcoma: translational data, clinical safety and efficacy.
Scientific reportsLeiomyosarcoma With Dedifferentiation Mimicking a Benign Neoplasm.
The American Journal of dermatopathologyCAR-T cell immunotherapy in rhabdomyosarcoma.
Journal of translational medicineInterdisciplinary therapy of extremity soft tissue sarcomas: current evidence on systemic treatments and the role of reconstructive surgery.
Innovative surgical sciencesEvaluating the Cost of Genomic Testing for Biomarker-Driven Therapies in Oncology.
Oncology and therapyPATIENTS WITH SOFT TISSUE SARCOMA AFTER TREATMENT BY NON ORTHOPEDIC ONCOLOGIC SURGEONS: EPIDEMIOLOGICAL PROFILE, STAGING, AND THERAPEUTIC CHALLENGES.
Acta ortopedica brasileiraReal-World Experience of Efficacy and Tolerability of Continuous Infusion Ifosfamide for Advanced Soft Tissue and Bone Sarcoma Patients: A Single Centre Retrospective Cohort.
Cancer medicineMultiple preoperative biopsies may increase histologic grade accuracy in canine soft tissue sarcoma: a prospective study.
Veterinary journal (London, England : 1997)Comparable Diagnostic Performance of 68Ga-FAPI and 18F-FDG PET/CT in Perineal Rhabdomyosarcoma.
Clinical nuclear medicineStewart-Treves syndrome: A fatal complication of rheumatoid arthritis-associated massive lymphedema.
JAAD case reportsLow-Grade Fibromyxoid Sarcoma and Related Subtypes: A Systematic Review and Pooled Analysis of 773 Cases.
CancersRadiomics of soft tissue sarcoma metastases to assess prognostic factors related to intrapatient intertumor heterogeneity.
Translational cancer researchNCCN Guidelines® Insights: Soft Tissue Sarcoma, Version 1.2025.
Journal of the National Comprehensive Cancer Network : JNCCNPredictive Value of Pretreatment SUVmax on 18 F-FDG PET Imaging for Survival Outcomes of Synovial Sarcoma in Pediatric Patients.
Journal of pediatric hematology/oncologyGemcitabine-docetaxel therapy in pediatric patients with relapsed or refractory sarcoma: a single-center experience.
Frontiers in pediatricsNumber of affected lymph nodes predicts outcome in extremity rhabdomyosarcoma.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyPreoperative hypofractionated radiotherapy in soft tissue sarcomas: institutional experience and clinical implications.
Clinical and translational radiation oncologyBAF complex-independent gene activation by SS18::SSX.
bioRxiv : the preprint server for biologyIndocyanine green assists with sentinel lymph node mapping in pediatric and adolescent patients: A Pediatric Surgical Oncology Research Collaborative prospective observational study.
CancerMRI findings for differentiating benign and malignant soft tissue tumors: a systematic review-part 2: key imaging findings.
Skeletal radiologyActivity of chemotherapy in mesenchymal chondrosarcoma: a multicentre retrospective analysis within the Italian Sarcoma Group network.
ESMO openPhase IB/II Trial with Correlative Analyses of Doxorubicin plus Durvalumab Combination in Patients with Advanced Soft Tissue Sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer ResearchMalignant nodular fasciitis, a rare manifestation of a benign disease: case report.
Frontiers in oncologyThe emerging role of mixed reality and artificial intelligence in sarcoma care: A systematic review.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyAdenosine A2B Receptor Promotes Tumor Progression and Metastases in Undifferentiated Pleomorphic Sarcoma.
Clinical cancer research : an official journal of the American Association for Cancer ResearchIntratumoral habitat and peritumor radiomics for progression risk stratification of patients with soft tissue sarcoma: a multicenter study.
Frontiers in oncologyLong-term clinical outcome of lung radiofrequency ablation in patients with musculoskeletal sarcoma.
International journal of clinical oncologyThe anti-apoptotic protein lifeguard is expressed in osteosarcoma, chondrosarcoma and soft tissue sarcoma.
OncologyA systematic review and meta-analysis of pazopanib efficacy and adverse effects in sarcomas.
Journal of translational medicineHigh-risk soft-tissue sarcomas in elderly patients: does perioperative radiotherapy improve local control and prognosis?
BMC cancerClear cell sarcoma : a retrospective review from a tertiary orthopaedic sarcoma unit.
The bone & joint journalDescribing the Mutational Characteristics of Myxofibrosarcoma: An AACR Project GENIE Analysis.
Anticancer researchHarnessing AACR Project GENIE to Define the Molecular Features of Desmoplastic Small Round Cell Tumor.
Current issues in molecular biologyRadiotherapy Combined with Immune Checkpoint Inhibitor on Murine Fibrosarcoma and a Narrative Review of Clinical Studies.
Current issues in molecular biologyRadiotherapy Response Prediction in Myxofibrosarcomas and Undifferentiated Soft Tissue Sarcomas Using DNA Methylation and Copy Number Profiling.
International journal of surgical pathologyDiscrimination performance in illness-death models with interval-censored disease data.
Statistical methods in medical researchPrimary Embryonal Rhabdomyosarcoma of the Breast: A Case Report and Literature Review.
Case reports in oncologyClinical evaluation, motor performance and quality of life in patients affected by Soft Tissue Sarcomas undergoing surgical treatment: observational study.
Frontiers in oncologyMRI Diffusion Imaging as an Additional Biomarker for Monitoring Chemotherapy Efficacy in Tumors.
Medicina (Kaunas, Lithuania)First-Line Chemotherapy Regimens for Advanced and Metastatic Leiomyosarcoma: Doxorubicin vs. Gemcitabine-A Systematic Review.
CancersMRI-Based Delta Necrosis as a Prognostic Marker Following Neoadjuvant Chemotherapy in Soft Tissue Sarcoma.
CancersUlcerated nodular fasciitis of the finger mimicking soft tissue sarcoma: a case report.
International cancer conference journalNTRK-rearranged soft tissue sarcoma that originated from the head and neck with a robust response to the TRK inhibitor larotrectinib.
International cancer conference journalRole of minimally invasive surgery in paediatric pulmonary metastatic disease.
EcancermedicalscienceUse of Razoxane as a radiosensitizer for the treatment of soft tissue sarcomas.
Expert review of anticancer therapyClinical outcome of 50 patients treated with eribulin for soft tissue sarcoma: a single-institute retrospective study.
Japanese journal of clinical oncologyOutcomes Following Combined Modality Treatment to the Primary Site in Select Patients With Metastatic Soft Tissue Sarcoma.
Practical radiation oncologyEvidence-based quality indicators of soft tissue sarcomas in Germany 2015-2021: An analysis of the German Cancer Registry Group.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyPulmonary metastasectomy from bone and soft tissue sarcomas: defining surgical indications at the time of second pulmonary recurrence.
International journal of clinical oncology[Hyperthermic isolated limb perfusion with TNF-alpha and melphalan for the treatment of locally advanced soft-tissue sarcoma].
Operative Orthopadie und Traumatologie[Systemic treatment of bone sarcoma, soft tissue sarcoma, GIST].
La Revue du praticien[Surgery of soft tissue sarcoma in adults].
La Revue du praticienVulvar dermatofibrosarcoma protuberans in a 55-year-old female: A case report, surgical reconstruction approach and literature review.
Gynecologic oncology reportsEffects of a tailored rehabilitation treatment in lower limb Soft Tissue Sarcomas reconstruction: a case series.
Journal of neuroengineering and rehabilitationTrace element profiles in canine neoplastic disease.
Veterinary journal (London, England : 1997)Unveiling the myxofibrosarcoma tumor microenvironment: implications for immunotherapy.
Frontiers in immunologySynovial Sarcoma Arising From the Falciform Ligament.
CureusA Primer for Pediatric Plastic Surgeons on Pediatric Head and Neck Malignancies: Part I-Epidemiology and Overview of Common Pediatric Head and Neck Tumors.
Annals of plastic surgeryAlveolar rhabdomyosarcoma with multiple bone marrow metastases: a case report.
BJR case reportsA Real-World Analysis of Outcomes in CIC-Rearranged Sarcomas: A Canadian Sarcoma Research and Clinical Collaboration (CanSaRCC) Study.
Cancer medicineA Rare Case of Recurrent Sarcoma Presenting as an Anterior Mediastinal Mass: Case Report.
Case reports in oncologyMonophasic synovial sarcoma of the thigh in a 60-year-old patient: A rare case report and literature review.
Radiology case reportsA Huge Recurrent Atypical Lipomatous Tumor (Well-Differentiated Liposarcoma) going in to Dedifferentiation 12 years after its First Detection.
Journal of orthopaedic case reportsOne case of left atrial arterial intimal sarcoma.
International journal of surgery case reportsAcute sciatic nerve palsy secondary to postoperative seroma following soft tissue sarcoma resection: A case report.
International journal of surgery case reportsClinical, Cytologic, Histopathologic, and Diagnostic Imaging of a Malignant Peripheral Nerve Sheath Tumor in the Renal Pelvis of a Border Collie Dog.
Veterinary clinical pathologyProteomic Profiling Reveals Candidate Proteins and Pathways Associated with Chemo-Radio-Sensitivity and Relapse in Rhabdomyosarcoma.
Journal of proteome researchA Causal Discovery Workflow for Rare Diseases: Experts-in-the-Loop Analysis of Sparse Longitudinal Data.
Journal of medical systemsNovel therapeutic potential of the PARP inhibitor talazoparib in synovial sarcoma and its combined effect with ATR inhibitor.
Discover oncologyHow Do Patient Demographics and Socioeconomic Disadvantage Impact Clinical Presentation, Surgical Outcomes, and Survival for Upper Extremity Soft Tissue Sarcoma?
Cancer reports (Hoboken, N.J.)The recurrence or metastasis related gene predicts the prognosis of extremity and trunk soft tissue sarcoma.
Precision clinical medicineEvaluation of magnetic resonance imaging parameters and compliance with guidelines in soft tissue sarcomas.
BMC cancerTreatment and Outcomes of Children and Adults With Rhabdomyosarcoma in Rwanda.
Pediatric blood & cancerClinical Significance and Therapeutic Potential of Long Non-Coding RNA H19 in Soft Tissue Sarcoma.
Cancer medicineFrom Numbers to Movement: Making the Toronto Extremity Salvage Score a Living Measure in Soft-tissue Sarcoma Survivorship.
Clinical oncology (Royal College of Radiologists (Great Britain))Inguinal "neoligament" reconstruction after groin soft tissue sarcoma resection: A novel surgical technique.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyRole of Dynamic Contrast-Enhanced MRI in Detecting Post-Treatment Local Recurrence of Soft-Tissue Sarcomas: A Systematic Review and Meta-Analysis.
Diagnostics (Basel, Switzerland)Total Quadriceps Resection in High-Grade Soft-Tissue Sarcomas of the Thigh: Surgical Technique and Long-Term Functional Outcomes in Surviving Patients.
CancersProteomics analysis of human mesenchymal stromal/stem cell sarcomagenesis model identifies ALDH1A3 and CD99 as potential targets in the transformation process.
BMC biologyHow Should Primary Pulmonary Sarcoma be Staged? Results of an International Multicentre Analysis.
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic SurgeryDistinct coexisting pathologies of oral malignant peripheral nerve sheath tumor with melanin pigmentation and indolent small lymphocytic lymphoma.
Discover oncologyVascular Reconstruction in Extremity Soft Tissue Sarcomas: A Systematic Review and Single-Arm Meta-Analysis.
Journal of surgical oncologyLong-term benefit from high-dose ifosfamide in sarcoma depends on sustained prior control and timely intervention: a machine learning analysis.
Journal of cancer research and clinical oncologyTumor Biomarkers in Peripheral Blood Liquid Biopsy of Soft Tissue Sarcomas: Research Progress and Clinical Applications in the Era of Precision Medicine.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae SinicaeEfficacy of larotrectinib in pediatric cancers with NTRK gene fusions.
Translational pediatricsBone and soft tissue sarcoma mortality in 19 811 patients diagnosed in Japan, 2006-2020.
JNCI cancer spectrumA comparison of upper versus lower extremity rhabdomyosarcoma survival: A SEER database analysis.
Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation OncologyClinico-Pathological and Clinical Outcomes of Soft Tissue Sarcoma With FUS-TFCP2 or EWSR1-TFCP2 Fusions: A Case Series From North India.
CureusArtificial intelligence in cancer genomics: refining diagnosis of hereditary breast and ovarian cancer syndromes.
Annals of medicine and surgery (2012)Comparison of two validated nomograms in patients with localized soft tissue sarcoma of the extremities and trunk wall.
Chinese clinical oncologyIntratumoral and peritumoral radiomics for the pretreatment prediction of response to neoadjuvant chemotherapy in rhabdomyosarcoma: a multicenter retrospective cohort study.
Insights into imagingCase Report: Bowel obstruction caused by an adult fibrosarcoma located in the pelvis.
Frontiers in surgeryRobotic-Assisted Cytoreductive Surgery and Hyperthermic Intrathoracic Chemotherapy in Metastatic Pleuropulmonary Leiomyosarcoma: A Case Report.
Case reports in oncological medicineCase Report: Recurrent phyllodes tumor of the breast with progressive malignant transformation.
Frontiers in oncologyPedicled latissimus dorsi flap and internal mammary perforator flaps for coverage of the latero-cervico-thoracic area after soft-tissue sarcoma resection: A case report.
Annales de chirurgie plastique et esthetiqueInfiltration of the oedema tail with tumour cells in patients with a soft-tissue sarcoma - the predisposing factors and clinical relevance : is the oedema tail contaminated tissue?
The bone & joint journalRole of Repeat Core Needle Biopsy After Nondiagnostic Initial Biopsy for Soft Tissue and Bone Sarcoma: Systematic Review and Meta-Analysis.
Journal of surgical oncologyDual role of IFNγ in reprogramming the undifferentiated pleomorphic sarcoma cell line JBT19 towards cytotoxic chemotherapy and antitumor immunity.
Oncology lettersOutcome of patients with curative-intent treatment for primary pulmonary sarcoma: Results from an international multicenter retrospective study.
JTCVS openDermatofibrosarcoma Protuberans of the Clavicular Skin in a 70-Year-Old Woman: Case Report and Management.
CureusReassessing the 8 cm Cutoff: Continuous Tumor Size-Mortality Risk Supports Three-Tier Staging in High Grade Osteosarcoma.
Journal of surgical oncologyActivation of the STING pathway potentiates the antitumor efficacy of doxorubicin in soft-tissue sarcoma.
Frontiers in oncologyReirradiation for locally recurrent soft tissue sarcomas: A systematic review.
Clinical and translational radiation oncologyDermatofibrosarcoma Protuberans of the Breast: A Rare Case Report.
Case reports in oncologyHigh-grade leiomyosarcoma of the common femoral vein masquerading as a femoral artery aneurysm in an elderly patient: A diagnostic challenge.
Radiology case reportsPharmacokinetics of pazopanib: a review of the determinants, influencing factors and the clinical importance of therapeutic drug monitoring.
The Journal of pharmacy and pharmacologyUpdate on pediatric soft tissue sarcomas.
Current opinion in pediatricsRetroperitoneal dedifferentiated liposarcoma with colon infiltration: a case report and literature review.
Frontiers in oncologyNeoadjuvant chemotherapy, DEB-TACE, and 3D-printed prosthesis for primary pelvic pleomorphic undifferentiated sarcoma: a case report.
Frontiers in oncologyA Comprehensive Review of Margin Identification Methods in Soft Tissue Sarcoma.
Current oncology (Toronto, Ont.)The Surveillance After Extremity Tumor Surgery (SAFETY) Pilot International Multi-Center Randomized Controlled Trial.
Current oncology (Toronto, Ont.)Human fibrosarcoma cells selected for ultra-high doxorubicin resistance, acquire trabectedin cross-resistance, remain sensitive to recombinant methioninase, and have increased c-MYC expression.
Frontiers in oncologyA 3D bioprinted liposarcoma tumor microenvironment model recapitulates stroma-driven invasion and chemoresistance.
Journal of materials chemistry. BTh17-like cells and immunosuppressive macrophages infiltrate tertiary lymphoid structures with distinct maturation status in soft-tissue sarcoma.
Cell death & diseaseEribulin and sintilimab combined with radiotherapy in a heavily pretreated patient with advanced retroperitoneal myxoid pleomorphic liposarcoma: a case report and literature review.
Frontiers in oncologyExploring hospital volume thresholds for improved sarcoma treatment across different age categories in the United States.
CancerA Comprehensive Review of Chemotherapy in Localized Soft Tissue Sarcomas: Is the Cat Out of the Bag Yet?
Indian journal of surgical oncologyMRI-based deep learning and radiomics pipeline for myxoid liposarcoma: a feasibility study in a rare sarcoma.
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Doença com base genética
Um médico geneticista pode ajudar no diagnóstico de Sarcoma de tecidos moles e no aconselhamento genético da família.
Doenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Perguntas frequentes
O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu
É um tipo de câncer que surge em tecidos como músculos, gordura, tecido fibroso ou vasos sanguíneos, poupando os ossos. Também recebe o nome de tumor mesenquimatoso maligno.
Referências
Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete
10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Citar este verbete
Raras. (s.d.). Sarcoma de tecidos moles. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/sarcoma-de-tecidos-moles
Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
Sarcoma de tecidos moles
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- Doença rara (ontologia)
- fonte: Orphanet
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- fonte: MONDO
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- fonte: GARD (NIH)
- Dado público estruturado
- fonte: Wikidata
- Medicamentos aprovados FDA
- fonte: FDA OpenFDA
- Reposicionamento
- fonte: Drug Repurposing Hub
- Ensaios clínicos
- fonte: ClinicalTrials.gov
