Um distúrbio do sono caracterizado por ter muita sonolência durante o dia, mesmo depois de ter dormido o suficiente à noite. As pessoas que sofrem dessa condição sentem muito cansaço e podem adormecer em momentos inadequados durante o dia.
Introdução
O que você precisa saber de cara
Um distúrbio do sono caracterizado por ter muita sonolência durante o dia, mesmo depois de ter dormido o suficiente à noite. As pessoas que sofrem dessa condição sentem muito cansaço e podem adormecer em momentos inadequados durante o dia.
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Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 23 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 37 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
8 genes identificados com associação a esta condição.
Neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested Binds to orexin receptors HCRTR1/OX1R and HCRTR2/OX2R with a high affinity (By similarity). Stimulates food intake (By simil
Rough endoplasmic reticulumCytoplasmic vesicleSynapse
Narcolepsy 1
Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication (Microbial infection) Acts as a receptor for rubella virus
Cell membrane
Narcolepsy 7
Neurological disabling sleep disorder, characterized by excessive daytime sleepiness, sleep fragmentation, symptoms of abnormal rapid-eye-movement (REM) sleep, cataplexy, hypnagogic hallucinations, and sleep paralysis. Cataplexy is a sudden loss of muscle tone triggered by emotions, which is the most valuable clinical feature used to diagnose narcolepsy. Human narcolepsy is primarily a sporadically occurring disorder but familial clustering has been observed.
Important for the overall degradation of proteins in lysosomes
Lysosome
Receptor for ATP and ADP coupled to G-proteins that activate both phosphatidylinositol-calcium and adenylyl cyclase second messenger systems. Not activated by UTP or UDP
Cell membrane
May play a role in uric acid excretion
Uric acid nephrolithiasis
A form of nephrolithiasis, a common multifactorial disease characterized by stones formation in the kidney and urinary tract. Nephrolithiasis is due to supersaturation of the urine by stone-forming constituents, including calcium, oxalate and uric acid. Crystals or foreign bodies can act as nidi, upon which ions from the supersaturated urine form microscopic crystalline structures. Uric acid nephrolithiasis occurs when the urine becomes overly concentrated with uric acid and accounts for 20% of all stones.
A beta chain of antigen-presenting major histocompatibility complex class II (MHCII) molecule. In complex with the alpha chain HLA-DRA, displays antigenic peptides on professional antigen presenting cells (APCs) for recognition by alpha-beta T cell receptor (TCR) on HLA-DRB1-restricted CD4-positive T cells. This guides antigen-specific T-helper effector functions, both antibody-mediated immune response and macrophage activation, to ultimately eliminate the infectious agents and transformed cells
Cell membraneEndoplasmic reticulum membraneLysosome membraneLate endosome membraneAutolysosome membrane
Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production
Membrane
Systemic lupus erythematosus
A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accommodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC
Cell membraneEndoplasmic reticulum membraneGolgi apparatus, trans-Golgi network membraneEndosome membraneLysosome membrane
Medicamentos aprovados (FDA)
3 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
77 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 61 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
15 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Narcolepsia
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
20 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 2.630
Patient-reported experiences of cognitive difficulties and their impact on daily life in narcolepsy type 1.
The cognitive difficulties experienced by individuals with narcolepsy type 1 (NT1), a rare and chronic neurological disorder, are understudied, with limited knowledge of their consequences in daily life. Here, we investigated the nature of cognitive difficulties and their consequences for daily life from the perspective of adults with NT1. In-depth, qualitative interviews were conducted with adults diagnosed with NT1 residing in the United States. Participants were recruited through (1) a patient advocacy organization (via social media and website); (2) a professional market research firm; and (3) participant referrals. Individual interviews were conducted by telephone, following a semi-structured guide, and lasted approximately 90 min. Qualitative analysis used an adapted grounded theory approach to identify key conceptual themes related to cognitive difficulties and their impacts on daily life. Of 46 participants, most reported experiencing some cognitive difficulties, with the most common being trouble remembering and difficulty with focus or sustained attention. Most participants characterized their difficulties with cognition as moderate or severe and reported these occurring daily. The qualitative findings informed the development of a conceptual model depicting cognitive difficulties and their broad impact on functioning and well-being in adults with NT1. Cognitive difficulties in adults with NT1 are frequent, severe, and described as interfering with daily life activities and well-being. These data highlight a clear need to assess cognitive function in people with NT1 and identify treatments that address NT1-associated cognitive symptoms.
Increased Numbers of CD4+ T-Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1.
Narcolepsy type 1 (NT1) is presumed to be an autoimmune disorder caused by hypothalamic loss of hypocretin (Hcrt; orexin). In postmortem NT1 brains, we observed an 11-fold increase of CD4+ T-cells in the Hcrt region compared with control hypothalami, without a corresponding rise in CD8+ T-cells. CD4+ and CD8+ T-cell numbers were unchanged in other hypothalamic regions, including the paraventricular nucleus and median eminence, and in extra-hypothalamic areas such as the substantia nigra and locus coeruleus. Hcrt-region CD4+ T-cells expressed the tissue-resident memory markers CD49a and CXCR6. These findings support the autoimmune hypothesis of NT1. ANN NEUROL 2026.
Rare-variant burden across lysosomal genes implicates sialylation and ganglioside metabolism in Parkinson's disease.
Lysosomal dysfunction is central to Parkinson's disease pathogenesis, with GBA1 as the strongest established genetic risk factor. Numerous other genes involved in lysosomal sphingolipid, glycosphingolipid and ceramide metabolism have been proposed as contributors to Parkinson's disease, underscoring the need for comprehensive genetic analyses across these pathways. We analysed rare variants (minor allele frequency < 0.01) across 36 lysosomal genes (excluding GBA1) in 8,267 individuals with Parkinson's disease and 68,208 controls, including a subset of 793 early-onset Parkinson's disease (≤50 years) cases. Targeted sequencing was performed in four cohorts at McGill University (3,456 Parkinson's disease patients and 2,664 controls) and results were combined with whole-genome sequencing data from the UK Biobank (2,848 cases, 62,451 controls), and from the Accelerating Medicines Partnership - Parkinson's Disease (1,963 cases, 3,093 controls). We analysed the association of rare variants in these genes with Parkinson's disease using Sequence Kernel Association Test-Optimal (SKAT-O) across variant classes (all rare variants, nonsynonymous, loss-of-function and predicted damaging variants with a Combined Annotation Dependent Depletion (CADD) score >20), with meta-analysis across cohorts. We additionally performed per-domain analyses for variants in gene segments encoding functional domains. False discovery rate correction was applied. Meta-analysis identified a significant association between rare variants in ST3GAL3 and Parkinson's disease (Pfdr=0.04). Several additional lysosomal genes showed nominal associations (P<0.05), including HGSNAT, ASAH1, CTSD, HEXA, ST3GAL4 and SGPP1. Domain-based analyses identified a strong enrichment of nonsynonymous variants within the beta-acetyl-hexosaminidase-like domain of HEXA (P = 8.0 × 10), although this signal did not survive correction for multiple testing (Pfdr=0.154). In early-onset Parkinson's disease, domain-based analyses revealed significant associations in NAGLU (Pfdr=7.3×10) and ST3GAL5 (Pfdr=0.03). Together, these results provide genetic evidence that rare variants across multiple lysosomal pathways, particularly those related to sialylation, ganglioside metabolism, ceramide biology, and lysosomal proteolysis, may contribute to Parkinson's disease susceptibility beyond GBA1, highlighting biologically coherent pathways for future replication and functional investigation.
How sleeping minds decide: State-specific reconfigurations of lexical decision-making.
Sleep has traditionally been conceptualized as a state of cognitive disconnection, yet emerging evidence indicates that decision-making capacities persist across sleep stages. Here, we elucidate the computational mechanisms underlying real-time lexical decision-making during polysomnographically-verified sleep, using facial electromyography and hierarchical drift diffusion modeling in both healthy individuals and participants with narcolepsy. We found that lexical decision-making was preserved during N1 and lucid REM sleep, but relied on distinct computational strategies: in N1 sleep, both enhanced sensory-motor processing and increased evidence accumulation supported decisions about words, whereas in lucid REM sleep, lexical decisions were driven exclusively by evidence accumulation processes. Cross-state comparisons revealed two fundamental principles: (1) Selective preservation-during N1 sleep, lexical decisions for words were maintained while those for pseudowords were selectively impaired, indicating that cognitive resources during sleep are preferentially allocated to meaningful stimuli; (2) Parallel strategic adaptations-during lucid REM sleep, participants increased their decision thresholds, requiring more evidence before responding, which helped maintain accuracy even though the efficiency of evidence accumulation was reduced. Our findings demonstrate that, rather than a passive decline, sleep involves dynamic and state-specific reconfiguration of the computational mechanisms underlying decision-making, with important implications for understanding consciousness and cognitive flexibility.
Bioinformatics identification and experimental validation of hub genes associated with narcolepsy type 1.
Narcolepsy type 1 (NT1) is a chronic neurological disorder with a genetic predisposition, yet its precise molecular pathogenesis remains unclear. Despite increasing recognition of its clinical and genetic basis, the precise molecular mechanisms remain unclear. This study aimed to identify NT1-associated hub genes and investigate their biological functions and interactions through comprehensive bioinformatics analysis, followed by experimental validation. NT1-related microarray data (GSE21592) were retrieved from Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were identified using integrated analysis with R software and the GEO2R platform. Functional enrichment analyses for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways were conducted using Database for Annotation, Visualization, and Integrated Discovery online tool. Protein-protein interaction (PPI) networks were constructed using STRING database and visualized with Cytoscape. Quantitative real-time PCR (qRT-PCR) was used to experimentally validate the expression of identified hub genes in NT1 patients. A total of 148 DEGs were identified. GO analysis revealed involvement primarily in biosynthesis, humoral immune response, viral gene expression, oxidoreductase activity, cytoplasmic translation, etc. KEGG analysis showed enrichment in oxidative phosphorylation, ribosomal pathways, thermogenesis, and glutathione metabolism pathways. Five hub genes - CREB1, PIK3R1, MED1, GATA3, and KDM5A - were identified from the PPI network. qRT-PCR validation confirmed significantly reduced expression of these genes in NT1 patients compared to healthy controls. Our study identified and experimentally validated five critical hub genes associated with NT1, providing new insights into its molecular mechanisms and highlighting potential therapeutic targets for future research and clinical intervention strategies.
Publicações recentes
Functional Regression Methods for Estimating 24-Hour Ambulatory Blood Pressure and Heart Rate Parameters in Narcolepsy Type 1.
🥉 Relato de casoAquaporin-4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders.
Clinical approaches to hypersomnolence complaints in psychiatry: A narrative review.
🥉 Relato de casoImpaired attention in pediatric narcolepsy type 1.
📖 RevisãoFirst orexin agonists address root cause of narcolepsy.
📚 EuropePMC3.387 artigos no totalmostrando 198
A longitudinal assessment of sleep architecture in children and adolescents with craniopharyngioma.
Sleep advances : a journal of the Sleep Research SocietyAssociation of GLP-1 Receptor Agonist Use with Hypersomnolence: A Real-world Cohort Analysis.
Journal of diabetes and metabolic disordersPatient-reported experiences of cognitive difficulties and their impact on daily life in narcolepsy type 1.
Frontiers in neurologyAn updated systematic review and meta-analysis of modafinil for excessive daytime sleepiness in narcolepsy.
Sleep medicine: XEffects of an orexin receptor 2-selective agonist on salivary secretion in rats.
Scientific reportsEffectiveness and Safety of Low-Sodium Oxybate in Participants with Idiopathic Hypersomnia: Primary Results from the DUET Study.
CNS drugsIncreased Numbers of CD4+ T-Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1.
Annals of neurologyNarcolepsy type 1: an autoimmune disease.
Trends in molecular medicineInvestigation of the "Not Better Explained" Diagnosis Criteria in Sleep Disorder Classifications: A Systematic Content Analysis and Critical Review.
Journal of sleep researchPatient-reported outcome measures in central disorders of hypersomnolence: consensus of a sleep consortium/RARE-X expert working group.
Sleep advances : a journal of the Sleep Research SocietyEffectiveness of Stimulant Treatment in Preventing Fractures and Head Injuries in Patients With Narcolepsy: A Self-Controlled Case Series Study.
PharmacotherapyMapping nocturnal arousal across sleep and pain disorders.
Scientific reportsTest-retest repeatability of the multiple sleep latency test in non-cataleptic hypersomnolence disorders.
Sleep medicine[Therapeutic potential of histamine N-methyltransferase inhibition for the treatment of hypersomnia].
Nihon yakurigaku zasshi. Folia pharmacologica JaponicaHomeostatic dysregulation of slow wave activity during sleep in Idiopathic Hypersomnia.
SleepRare-variant burden across lysosomal genes implicates sialylation and ganglioside metabolism in Parkinson's disease.
medRxiv : the preprint server for health sciencesNarcolepsy and metabolic disease: A meta-analytic synthesis.
Sleep medicine reviewsInitial validation of a pediatric cataplexy survey for children and adolescents with narcolepsy type 1.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep MedicineHow sleeping minds decide: State-specific reconfigurations of lexical decision-making.
PLoS computational biologySamelisant (SUVN-G3031), a histamine H3 receptor inverse agonist, as a potential treatment for narcolepsy: a phase-2 drug evaluation.
Expert opinion on investigational drugsUnder-Recognition of Rapid Eye Movement Sleep Behavior Disorder in Younger Populations.
Sleep medicine clinicsDisparities in Diagnosis of and Management of Narcolepsy and Idiopathic Hypersomnia.
Sleep medicine clinicsNovel Cyclopentapyrrole Compounds as Orexin Receptor Agonists for Treating Sleep Disorders, namely, Narcolepsy and Hypersomnia.
ACS medicinal chemistry lettersGhrelin's role in sleep and sleep deprivation: a narrative review.
Frontiers in psychiatryBioinformatics identification and experimental validation of hub genes associated with narcolepsy type 1.
Journal of clinical and translational scienceEpidemiology and Economic Burden of Sleep Disorders in Europe.
European journal of neurologyCataplexy-Like Episodes Following Suvorexant Use in a Non-Narcoleptic Patient: A Brief Report.
Journal of sleep researchClinical significance of ADHD traits in central disorders of hypersomnolence.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep MedicineIdiopathic hypersomnia is a 24-hour disorder.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep MedicineClinical and polysomnographic changes in idiopathic hypersomnia ten years after the diagnosis.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep MedicineUnravelling Narcolepsy: A Series of Complex Pediatric Cases.
Neurology. Clinical practiceMazindol Immediate-Release/Sustained-Release (IR/SR): A 50-Year Legacy of Multifaceted Mechanisms and Emerging Therapeutic Potential.
Clinical drug investigationiSPHYNCS: Unsupervised Clustering in Questionnaires and Metadata Reveals Distinct Subtypes in the Narcolepsy Borderland.
Journal of sleep researchAn Unusual Case of Hypersomnolence.
Annals of African medicineIncidence and prevalence of obstructive sleep apnoea and narcolepsy in the UK: a population-based descriptive study.
Thorax[Chinese expert consensus on the clinical application of wake-promoting agents].
Zhonghua nei ke za zhiMicrobial-Immune Interplay in CNS Autoimmune Diseases: Lessons from Animal Models and Clinical Studies.
European journal of immunologyPerspectives on idiopathic hypersomnia: diagnostic challenges, unknown pathophysiological, and emerging therapeutic strategies.
SleepDifferential motor signatures in isolated and narcolepsy-related REM sleep behaviour disorder: a preliminary study.
Frontiers in neurologyPitolisant-associated mania - a case report.
BMC neurologySkin thermal dynamics and hypothalamic thermosensitivity dissociate REM sleep and cataplexy in narcolepsy.
Science translational medicineInterpreting the Study on Narcolepsy and Cardiovascular Outcomes: Expanding Clinical Perspectives.
SleepHigh-resolution sleep fragmentation assessment in narcolepsy type 1 and their non-narcoleptic siblings: a 5-second mini-epoch study.
SleepGlymphatic dysfunction and its association with clinical symptom severity in narcolepsy type 1: a case-control DTI-ALPS study.
BMC neurologyA real-world study on the treatment of pediatric narcolepsy with pitolisant in China.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology"A nano-enabled screen-printed paper-based electrochemical device with a 3D-printed wristband cassette design for selective and real-time detection of club drug amphetamine in complex matrices".
Biomedical microdevicesSleep, wake, and signaling: Functional profiling of orexin agonists and antagonists using newly developed orexin β-arrestin 2 and miniGαq recruitment assays.
European journal of pharmacologyDisorder-specific alterations of transient oscillatory dynamics during sleep across cortical and subcortical networks.
Scientific reportsStiff Person Syndrome: A Case Report.
CureusClinical significance of nocturnal sleep onset REM periods in narcolepsy diagnosis and diagnostic stability.
Sleep and biological rhythmsToward better subcategorization of narcolepsy type 2.
Sleep and biological rhythmsDelayed Emergence From Anesthesia After Esophagogastroduodenoscopy/Colonoscopy in an Adult Patient With Narcolepsy.
ACG case reports journalSleep apnoea and its consequences: from animal models to precision medicine.
Sleep medicineSecondary narcolepsy and cognitive dysfunction related to craniopharyngioma: a case study.
BMC neurologyIntelligence quotient in adults with idiopathic hypersomnia and narcolepsy type 1.
Sleep medicineSleep neurology: pearls and pitfalls.
Practical neurologyCircadian Variations in Cognitive Performance Among Patients With Narcolepsy and Obstructive Sleep Apnea: A Comparative Study.
Alpha psychiatryClinical and socioeconomic burden among people with narcolepsy or idiopathic hypersomnia: A retrospective cohort analysis of the Danish National Patient Registry.
Sleep medicineResearch Progress in the Roles of Influenza A H1N1 Virus and Its Vaccine in the Pathogenesis of Narcolepsy Type 1.
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae SinicaeOrexin receptor 2 agonists: a pathophysiologic approach to narcolepsy type 1.
Annals of medicine and surgery (2012)Circadian rest-activity rhythm in patients with narcolepsy following modafinil treatment: Outcomes and predictive markers.
Sleep medicineSleep Disorders and Nonalcoholic Fatty Liver Disease: Evidence From Meta-Analysis and Mendelian Randomization.
Journal of prevention (2022)[Huntington's disease presenting with schizophreniform psychosis and narcolepsy in the premotor phase].
Orvosi hetilapA case and review of fibroblast growth factor-23-mediated hypophosphatemic osteomalacia in the absence of pathogenic PHEX variants.
JBMR plusNarcolepsy Associated With Streptococcal Infection: A Case Report and Literature Review.
Clinical case reportsClinical and instrumental comparison between insufficient sleep syndrome and narcolepsy type 1.
Sleep medicineSleep stage classification from ECG using machine learning: Evaluating the impact of signal duration.
Neurobiology of sleep and circadian rhythmsMass Spectrometry-Based Quantification of Orexin Species in Human Cerebrospinal Fluid Reveals Differential Dynamics Associated with Sleep.
medRxiv : the preprint server for health sciencesSerum Metabolomic Signatures of Dyslipidemia in Narcolepsy Type 1: A Multi-Center Cross-Sectional Study.
Nature and science of sleepCausality of blood metabolites and narcolepsy type 1: A Mendelian randomization study.
MedicineHistamine N-methyltransferase inhibition as a novel therapeutic strategy for idiopathic hypersomnia.
European journal of pharmacologyBupropion for Treatment of Depression and Narcolepsy in a Postpartum Patient.
The primary care companion for CNS disordersNeuroimaging findings in sleep disorders: A review article.
Neurobiology of sleep and circadian rhythmsLack of association between G6PD variants and Parkinson disease.
HGG advancesA Comprehensive Review of Current and Emerging Treatments for Narcolepsy Type 1.
Journal of clinical medicineAssessing Condition-Specific Adverse Event Profiles of Modafinil for Labelled and Off-Label Uses: A Systematic Review and Meta-Analysis.
Basic & clinical pharmacology & toxicologyHLA-DQB1*03:01 strongly affects age of onset of type 1 narcolepsy independently of DQA1 and ethnicity.
Proceedings of the National Academy of Sciences of the United States of AmericaThe Risks of Injury and Accident in Patients With Central Hypersomnia: A Cohort Study in Taiwan.
Journal of sleep researchEffects of Oveporexton, an Orexin Receptor 2-Selective Agonist, on Cognition in Narcolepsy Type 1: A Secondary Analysis of a Randomized Clinical Trial.
JAMA neurologyClinical pearls for the treatment of narcolepsy.
The mental health clinicianNarcolepsy: Pathophysiology, Diagnosis, Management, and Future Directions, a Narrative Review.
Brain and behaviorTactile Hallucinations in Pediatric and Young Adults With Narcolepsy: A Case Series and Review of the Literature.
Pediatric neurologyClassification and clustering on nocturnal polysomnography: distinctions and overlaps between central disorders of hypersomnolence.
SleepLack of epistatic interaction of SNCA with APOE in synucleinopathies.
Brain communicationsArchetypal Analysis for the Characterization of Distinct Patterns in Mouse Sleep Data.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International ConferenceFrom Normal Variation in Sleep to Clinical Sleep Disorders: Genetic Insights from Over One Million Individuals.
medRxiv : the preprint server for health sciencesArtificial intelligence and sleep medicine II: A scoping review of applications, advancements, and future directions.
Sleep medicine reviewsSleep disturbances in craniopharyngioma: a systematic review and meta-analysis.
PituitaryEfficacy and Safety of Pitolisant for Excessive Daytime Sleepiness in Narcolepsy and Obstructive Sleep Apnea: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.
The Annals of pharmacotherapy'It's hard to feel this way every single day': patients' perspectives on the emotional burden of narcolepsy.
Frontiers in psychologyCannabis Use in Central Disorders of Hypersomnolence in the Netherlands.
Medical cannabis and cannabinoidsSleep time and SOREMPs features support idiopathic hypersomnia and narcolepsy type 2 as a single disease entity.
SleepAnimal Models of Narcolepsy: From Orexin Deficiency to Immune Mechanisms and Regenerative Therapies.
Current issues in molecular biologyTablet-Assisted Speech and Language Therapy for Acute Post-Stroke Aphasia: A Randomized Clinical Trial (LEXI Study).
European journal of neurologyRisk of neurologic or immune-mediated adverse events after COVID-19 diagnosis in the United States.
PloS oneThe incidence, prevalence and treatment of narcolepsy in New Zealand.
The New Zealand medical journalDevelopment of Novel 18F‑Labeled Selective Orexin‑2 Receptor Radioligands for Positron Emission Tomography.
ACS pharmacology & translational scienceVery late-onset narcolepsy type 1: diagnosis in the ninth decade.
BMJ case reports"My Partner Just Wants to Sleep": A Qualitative Study of the Experience of Living with a Partner with Narcolepsy or Idiopathic Hypersomnia.
Behavioral sleep medicineHypothalamic functional connectivity, depressive symptoms, and post-treatment SOREMPs in narcolepsy type 1: links to sleep latency and mediation mechanisms.
Translational psychiatryComparative efficacy of new wake-promoting agents for narcolepsy-a network meta-analysis.
BMC neurologyAltered Sleep Patterns in Wilson's Disease Including Shortened REM Latency.
Diagnostics (Basel, Switzerland)A new decision-making approach for residual excessive daytime sleepiness in patients treated for OSAHS: the Blob-Algorithm proposition.
SleepAssociation between lipopolysaccharide-binding protein levels and disease severity in pediatric narcolepsy: A cross-sectional study.
Sleep medicineCircadian Modulation of Sleep-Wake Behavior in Patients with Narcolepsy Type 1 and Idiopathic Hypersomnia.
Nature and science of sleepProlintane analogs as hybrid monoamine transporter ligands: Structural determinants and species differences.
The Journal of biological chemistryImpact of neuromodulation on excessive daytime sleepiness: a narrative review.
Frontiers in psychiatryAttention and inhibition deficits in narcolepsy type 1: behavioral and electrophysiological markers.
Translational psychiatryCo-morbid monogenic disorders at chromosome region 1q2: LMNA- and FLG-related disorders in a patient referred for assessment of joint hypermobility.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biologySleep Disorders, Dysregulation of Circadian Rhythms, and Fatigue After Craniopharyngioma-A Narrative Review.
BiomedicinesGuidelines From the French-Speaking Society for Histocompatibility and Immunogenetics (SFHI) for Harmonisation of HLA Genotyping in Autoimmune Diseases, Drug Hypersensitivity and Pharmacogenetics.
HLAMortality Risk Study Offers Good News for Patients With Narcolepsy.
JAMAThe impact of sleep disturbance on post-transplant recovery and quality of life: Neural mechanisms and translational management strategies.
Behavioural brain research[Symptomatic Narcolepsy due to Neurological Disorders].
Brain and nerve = Shinkei kenkyu no shinpo[Pathophysiology of Narcolepsy].
Brain and nerve = Shinkei kenkyu no shinpo[Autoimmune Encephalitis and Associated Sleep Disorders].
Brain and nerve = Shinkei kenkyu no shinpo[Neural Circuit Mechanisms Underlying REM Sleep].
Brain and nerve = Shinkei kenkyu no shinpoEffects of High- Versus Low-Sodium Oxybate on Blood Pressure in Patients With Narcolepsy.
Hypertension (Dallas, Tex. : 1979)Sleep disturbances in brain tumors: a narrative review.
Frontiers in oncologyAssessing sleep disorders in neuromyelitis optica spectrum disorder: A comparison of qualitative and quantitative approaches.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaOrexin Deficiency in Narcolepsy: Molecular Mechanisms, Clinical Phenotypes, and Emerging Therapeutic Frontiers.
Brain and behaviorAll-Cause and Cause-Specific Mortality Among Patients With Narcolepsy.
JAMA network openStridor Is an Independent Risk Factor for Mortality and Disease Progression in Patients with Multiple System Atrophy.
Movement disorders : official journal of the Movement Disorder SocietyImproving Daytime Sleepiness in Children and Adolescents With Narcolepsy: A Quality Improvement Initiative.
Pediatric neurologyChallenges and methodological considerations for research on the role of sleep stage transitions in altered affective processing.
Sleep advances : a journal of the Sleep Research SocietyUsing Real-time Reporting to Investigate Visual Experiences in Dreams.
Journal of cognitive neuroscienceUnderestimation of nocturnal sleep duration in central disorders of hypersomnolence: an underrecognized feature?
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep MedicineOrexin 1-16 as the stable metabolite behind low CSF orexin/hypocretin immunoreactivity in narcolepsy.
SleepPharmacovigilance Insights into Ibuprofen's Neuropsychiatric Safety: A Retrospective Analysis of EudraVigilance Reports.
Pharmaceuticals (Basel, Switzerland)The role of orexin and MCH neurons in the hypothalamus in sleep-wake regulation and learning-forgetting balance.
Frontiers in neuroscienceAssociation between cytokines and neuropsychiatric symptoms in paediatric narcolepsy patients: a cross-sectional study.
BMC neurologyUnderstanding idiopathic hypersomnia: diagnosis, pathophysiology, and management.
Current opinion in pulmonary medicineHow golden age Arab-Islamic scholars revolutionized sleep physiology and dream analysis.
Journal of Taibah University Medical SciencesDynamic Functional Network Connectivity Patterns Distinguish Neurobiological Substrates of Narcolepsy Type 1 and Idiopathic Hypersomnia: Potential Biomarkers From Resting-State fMRI.
Journal of sleep researchPhysical activity: a safe step toward better quality of life in narcolepsy.
SleepPost-marketing safety of solriamfetol: A retrospective pharmacovigilance study based on the us food and drug administration adverse event reporting system.
PloS oneCentral disorders of hypersomnolence - A narrative review on current and potential biomarkers.
Sleep medicine reviewsDNA methylation and multi-omics profiling of T cells uncovers chemotactic pathways and proliferation-linked hypomethylation in narcolepsy type 1.
SleepPost-traumatic stress disorder and REM-sleep behavior disorder: exploring genetic associations and causal links.
medRxiv : the preprint server for health sciencesPhasic events, cyclic alternating pattern (CAP) and sleep disorders.
Clinical neurophysiology : official journal of the International Federation of Clinical NeurophysiologySolriamfetol improves daily fatigue symptoms in adults with myalgic encephalomyelitis/chronic fatigue syndrome after 8 weeks of treatment.
Journal of psychopharmacology (Oxford, England)Hummingbird sign in a patient with DNMT1-related disorder.
NeurocaseFeasibility and efficacy of exercise training on sleep symptoms and comorbidities in narcolepsy type 1: a prospective interventional study.
SleepHypocretin: a promising target for the regulation of homeostasis.
Frontiers in neuroscienceREM Density, Leg Movements, and REM Sleep without Atonia: Differentiating Type 1 from Type 2 Narcolepsy Through Polysomnographic Analysis, a Preliminary Study.
Nature and science of sleepSleep Paralysis: Pathogenesis, Clinical Manifestations, and Treatment Strategies.
Journal of integrative neuroscienceDissolution of Once-Nightly Sodium Oxybate in Soft Foods and Alternative Liquid Reconstitution Vehicles.
Clinical therapeuticsPrevalence and Factors Associated with Rapid Eye Movement-Related Obstructive Sleep Apnea in Patients with Narcolepsy.
Nature and science of sleepA comprehensive study on drug-related Raynaud's phenomenon based on the FDA adverse event reporting system.
Scientific reportsUnique Polysomnography Pattern Leading to the Diagnosis of Anti-Ma2 Encephalitis.
Neurology(R) neuroimmunology & neuroinflammationLocalized and historical hypermobile spectrum disorders share self-reported symptoms and comorbidities with hEDS and HSD.
Frontiers in medicineQuantification of electromyographic activity during REM sleep in Chinese narcolepsy patients and healthy controls: a comparative study.
Sleep & breathing = Schlaf & AtmungDecoding ligand recognition and constitutive activation of histamine H3 and H4 receptors.
Acta pharmacologica SinicaNarcolepsy 2025 (with an Australasian perspective).
Internal medicine journalFacial Emotion Recognition in Children With Narcolepsy Type 1.
Journal of sleep researchTransforming sleep medicine: the evolving role of artificial intelligence.
Current opinion in pulmonary medicineOnce-Nightly Sodium Oxybate Meets American Academy of Sleep Medicine Criteria for Treatment of Narcolepsy.
Journal of sleep researchBeyond neuronal loss: epigenetic signatures bridging immune activation and sleep dysfunction in narcolepsy type 1.
SleepHypocretin/orexin peptide release occurs mostly extrasynaptically, is self-controlled, and specifically enhanced in female rats.
Experimental neurologyUsefulness of the adult concentration inventory in the psychological assessment of adult sleep disorder patients.
Sleep medicineThe impacts of sleep loss on wake-active neurons.
SleepSelective modulation of orexinergic receptors by neem-derived phytochemicals: Computational analysis of structure-activity relationships.
Toxicology reportsNarcolepsy and risk of cardiovascular outcomes: getting to the heart of the matter.
SleepInitial experience and establishment of a hypersomnia board: A multidisciplinary approach to complex hypersomnia cases.
Sleep medicineAge at Onset and Delays in Diagnosis of Central Disorders of Hypersomnolence Over the Past 30 Years.
Journal of sleep researchRestless Legs Syndrome, Periodic Leg Movements, Hypertension and Cardiovascular Diseases.
Circulation researchNarcolepsy type 2 is an unstable diagnosis and idiopathic hypersomnia has the potential for remission-long-term and cross-sectional observations from the Bern Sleep-Wake Registry.
SleepMolecular Pathways Potentially Involved in Hallucinatory Experiences During Sleep Paralysis: The Emerging Role of β-Arrestin-2.
International journal of molecular sciences16-mer hypocretin-1/orexin-A in cerebrospinal fluid to diagnose narcolepsy.
SleepThe Clinical and Economic Burden of Idiopathic Hypersomnia and Narcolepsy: A United States Claims-Based Analysis.
Nature and science of sleepNeuroinflammation distinguishes HLA haplotypes in progressive supranuclear palsy.
medRxiv : the preprint server for health sciencesBeyond Pediatric Sleep Disorders: A Case of Hypersomnia Revealing Hashimoto's Encephalopathy.
CureusLeading orexin receptor agonist clears phase III for narcolepsy.
Nature reviews. Drug discoveryTelomere length in sleep disorders.
Experimental gerontologyOrexin effect on physiological pulsations of the human brain.
Proceedings of the National Academy of Sciences of the United States of AmericaResearch progress in sleep disorders associated with multiple sclerosis.
Multiple sclerosis and related disordersQuality measures for care of patients with narcolepsy: 2025 update after measure maintenance.
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep MedicineDriving Safety among Adolescents with Health Conditions: An Integrative Review.
Journal of transport & healthA Permutation Entropy Method for Sleep Disorder Screening.
Brain sciencesDepressive symptoms and suicidal thoughts in idiopathic hypersomnia: a cross-sectional and longitudinal study.
SleepCorticotropin-Releasing Hormone (CRH) in Murine Narcolepsy: What Do Genetic and Immune Models Tell Us?
Journal of sleep researchArtificial Intelligence Chatbots and Narcolepsy: Friend or Foe for Patient Information?
European neurologyThe inter-night variability of REM sleep without atonia in adult patients with central disorders of hypersomnolence.
Sleep medicineCurrent insights into the safety and adverse effects of methylphenidate in children, adolescents, and adults - narrative review.
Pharmacological reports : PRCorrigendum to "Factors associated with diagnostic delay in narcolepsy: Real-world data from a Korean multicenter study" [Sleep Med 133 (2025) 106646].
Sleep medicineManagement of Insomnia Complaints by Non-Sleep Specialist Physicians: A French DELPHI Consensus.
Journal of sleep researchGreen spectrofluorimetric method for quantification of sodium oxybate in pharmaceutical and plasma samples.
Scientific reportsIntegrative evidence linking excessive daytime sleepiness, narcolepsy, and hypertension: insights from NHANES, Mendelian randomization, and proteomics.
European journal of medical researchDiscovery of natural orexin 2 receptor antagonists from Valeriana species: A potential approach for insomnia treatment.
Chronobiology internationalEvaluating the safety of XBB.1.5-containing COVID-19 mRNA vaccines using a self-controlled case series study.
Nature communicationsRelationship between sleep characteristics and aortic aneurysm/dissection: a two-sample Mendelian randomisation study.
BMJ openNarcolepsy and risk of cardiovascular outcomes beyond stimulant use.
SleepMolecular Insights into the Interaction of Orexin 1 Receptor Antagonists: A Comprehensive Study Using Classical and Quantum Computational Methods.
Molecules (Basel, Switzerland)Narcolepsy: a machine learning bibliometric analysis (1996-2024).
Frontiers in neurologyAbnormal brain functional network dynamics in narcolepsy type 1 patients.
Clinical neurophysiology : official journal of the International Federation of Clinical NeurophysiologyA path analysis of factors influencing life satisfaction among patients with narcolepsy in Japan.
GHM openNon-obstructive sleep apnea pediatric sleep disorders: what the otolaryngologist should know.
Current opinion in otolaryngology & head and neck surgeryThe burden of narcolepsy symptoms from patients' perspective: a narrative qualitative study.
Sleep & breathing = Schlaf & AtmungAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Comunidades
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Patient-reported experiences of cognitive difficulties and their impact on daily life in narcolepsy type 1.
- Increased Numbers of CD4+ T-Cells in the Hypocretin/Orexin Region of Narcolepsy Type 1.
- Rare-variant burden across lysosomal genes implicates sialylation and ganglioside metabolism in Parkinson's disease.
- How sleeping minds decide: State-specific reconfigurations of lexical decision-making.
- Bioinformatics identification and experimental validation of hub genes associated with narcolepsy type 1.
- Functional Regression Methods for Estimating 24-Hour Ambulatory Blood Pressure and Heart Rate Parameters in Narcolepsy Type 1.
- Aquaporin-4 in Narcolepsy Type 1: Investigation of Perivascular Fluid Movement in Sleep Disorders.
- Clinical approaches to hypersomnolence complaints in psychiatry: A narrative review.
- Impaired attention in pediatric narcolepsy type 1.
- First orexin agonists address root cause of narcolepsy.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:619284(Orphanet)
- MONDO:0021107(MONDO)
- GARD:22460(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
