Acromegalia é uma doença adquirida, causada pela produção excessiva do hormônio do crescimento (GH). Ela se manifesta por alterações progressivas no corpo (principalmente no rosto, mãos e pés) e outros problemas que afetam o organismo inteiro.
Introdução
O que você precisa saber de cara
Acromegalia é uma doença adquirida, causada pela produção excessiva do hormônio do crescimento (GH). Ela se manifesta por alterações progressivas no corpo (principalmente no rosto, mãos e pés) e outros problemas que afetam o organismo inteiro.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Entender a doença
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 45 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 93 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
2 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
Orphan receptor
Cell membrane
Pituitary adenoma 2, growth hormone-secreting
A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.
May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation
Mitochondrion matrixNucleus
Medicamentos aprovados (FDA)
3 medicamentos encontrados nos registros da FDA americana.
Variantes genéticas (ClinVar)
392 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
4 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Acromegalia
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
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Outros ensaios clínicos
201 ensaios clínicos encontrados, 17 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 3.290
Neuropsychological profile in acromegaly: a single center cross sectional analysis and preliminary prospective long-term study.
Este estudo revela que pacientes com acromegalia frequentemente apresentam transtornos de ansiedade (35%) e depressão (23%), predominantemente naqueles com doença ativa, e demonstram um desempenho neurocognitivo significativamente inferior em áreas como memória e atenção, comparado a indivíduos saudáveis. Níveis elevados de IGF-1 e hipopituitarismo foram associados a um pior desempenho cognitivo. Para pacientes e médicos, isso significa a importância de monitorar e abordar tanto o bem-estar psicológico quanto a função cognitiva, pois o controle da atividade da doença pode estar ligado a uma melhora global a longo prazo nesses domínios.
🇧🇷 traduzidoCase Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.
Este caso descreve um cão diabético com acromegalia (excesso de hormônio do crescimento devido a um tumor hipofisário), que causava diabetes de difícil controle e resistência à insulina. Embora a cirurgia para remover o tumor tenha normalizado com sucesso os níveis hormonais (GH e IGF-1), o diabetes e a necessidade de insulina persistiram, culminando na eutanásia do animal cerca de 9 meses depois. Isso destaca que, apesar da eficácia da cirurgia na correção hormonal, o diabetes pode não se reverter completamente, um ponto crucial para médicos veterinários e tutores considerarem no manejo desta condição.
🇧🇷 traduzidoAcromegaly presenting with normal insulin-like growth factor-1 levels in a patient with advanced liver cirrhosis.
Este caso demonstra que a acromegalia pode se apresentar com níveis normais do fator de crescimento IGF-1 em pacientes com cirrose hepática avançada, devido ao papel vital do fígado na produção de IGF-1. Nesses casos, é crucial que médicos se guiem pelos sintomas clínicos, exames como o de supressão de GH e julgamento clínico, pois a disfunção hepática pode mascarar a doença. Isso é importante para pacientes e médicos para evitar o subdiagnóstico da acromegalia em indivíduos com doença hepática.
🇧🇷 traduzidoSerum Lipidomic Profile Signature of Active Acromegaly and Relationships to Cardiovascular Disease.
Este estudo revelou que pacientes com acromegalia ativa apresentam um perfil lipídico sanguíneo alterado, destacando a esfingomielina SM 34:0;O2 e a fosforilcolina como potenciais biomarcadores que podem diferenciar a doença e indicar sua gravidade, especialmente em casos não tratados. Além disso, foram identificadas alterações lipídicas específicas associadas a complicações cardiovasculares, como hipertensão e insuficiência cardíaca, fornecendo aos médicos novas ferramentas para avaliar o risco e aos pacientes uma compreensão mais profunda da ligação entre a acromegalia e a saúde do coração.
🇧🇷 traduzidoAltered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing.
Este estudo revelou que pacientes com acromegalia apresentam alterações significativas na função e conectividade de redes cerebrais ligadas à cognição e emoção, resultando em menor desempenho cognitivo. Para médicos, as mudanças detectadas por ressonância magnética funcional (fMRI) podem classificar pacientes com alta precisão (85.11%), oferecendo uma ferramenta promissora para diagnóstico e monitoramento. Para pacientes, isso explica as dificuldades cognitivas e emocionais associadas ao excesso de hormônio do crescimento no cérebro.
🇧🇷 traduzidoPublicações recentes
The Many Faces of Acromegaly: Understanding Its Clinical and Biological Heterogeneity.
Disease-related burden and treatment experience in patients with acromegaly: a gender perspective.
Long-term safety and efficacy of pegvisomant monotherapy for acromegaly: final data from the full ACROSTUDY cohort.
Current Controversies in Acromegaly Care.
Acromegaly in an Elderly Woman.
📚 EuropePMC6.824 artigos no totalmostrando 189
Clinicopathological analysis of 19 cases of mixed gangliocytoma-pituitary neuroendocrine tumors.
Diagnostic pathologyPPAR-α activator pemafibrate lowered plasma insulin-like growth factor-1 level in a patient with acromegaly.
Endocrinology, diabetes & metabolism case reportsDisease burden, treatment experiences and preferences in patients with acromegaly: a qualitative study.
Frontiers in endocrinologyCAVERNOUS SINUS MEDIAL WALL RESECTION IN INVASIVE PITUITARY ADENOMAS: OUTCOME IN ACROMEGALY.
World neurosurgeryLumbar spinal stenosis in patients with acromegaly: an MRI-based case-control study.
World neurosurgeryJAK2 inhibition with baricitinib stunts growth and postnatal development in juvenile rats.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieSynthetic somatostatin analogs ameliorate endothelial injury due to hydrochloric acid treatment.
Environmental toxicology and pharmacologyNeuropsychological profile in acromegaly: a single center cross sectional analysis and preliminary prospective long-term study.
Frontiers in neurologyAgeing and pituitary neuroendocrine tumours (PitNETs): from bench to bedside.
Endocrine-related cancerAnti-secretory and anti-proliferative actions of next-generation dual subtype 2 and 5 somatostatin receptor ligands in neuroendocrine tumor models.
Frontiers in oncologyA Cross-Sectional Analysis of Musculoskeletal and Functional Outcomes in Patients with Pituitary Disorders: Frailty and Sarcopenia.
Journal of clinical medicinePathogenesis of Non-Familial Somatotroph Adenomas.
The Journal of clinical endocrinology and metabolismProgression of acromegalic joint and psychological complications according to sex, treatments, and disease control.
European journal of endocrinologyCase Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.
Frontiers in veterinary science[Guidelines for the diagnosis and treatment of obstructive sleep apnea in adults (2025)].
Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseasesCytokeratin 5.2 expression as a predictive marker of outcome in patients with acromegaly following endoscopic transsphenoidal surgery.
PituitaryQuality of life questionnaires in patients with acromegaly: a scoping review.
Journal of patient-reported outcomesImpact of pain on quality of life (QoL) in patients with acromegaly: profound differences in physical and mental aspects of QoL.
EndocrineThyroid cancer and thyroid nodules in acromegaly: a single-center retrospective study.
EndocrineRisk of cerebrovascular and cardiovascular events in acromegaly: a systematic review and meta-analysis.
EndocrineCost-effectiveness of personalized medical treatment in acromegaly: a post hoc analysis of the ACROFAST study.
Journal of the Endocrine SocietyEvaluation of static and dynamic pupil responses in patients with acromegaly with automatic pupillometer.
BMC ophthalmologyThe clinical value of [18F]-fluoro-ethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.
PituitarySex differences in the clinical presentation, management and long-term outcomes of pituitary tumors in children and adolescents.
PituitaryPaltusotine: The first FDA approved oral treatment for acromegaly.
Annals of medicine and surgery (2012)Anesthetic management of a patient with McCune-Albright syndrome complicated by pathological cervical fracture: a case report.
BMC anesthesiologyDistribution, Severity and Management of Joint Pain in Patients with Acromegaly.
European journal of endocrinologyEfficacy and Safety of Pharmacologic Therapies in Acromegaly: A Systematic Literature Review and Network Meta-Analysis.
The Journal of clinical endocrinology and metabolismA QbD-informed study of permeation enhancer-octreotide nanoscale interactions influencing performance in pullulan buccal films.
International journal of pharmaceuticsClinical performance of an IGF1 LC-MS/MS assay and associated normative dataset in routine endocrinology.
European journal of endocrinologyPrevalence and clinical correlates of pre-operative glucose homeostasis in patients with acromegaly.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research SocietyAutomatic acromegaly detection using deep learning on hand images: a multicenter observational study.
The Journal of clinical endocrinology and metabolismCancer Risk in Patients with Acromegaly: Insights from a Single Center in Ankara.
Journal of clinical medicineCalcitonin Gene-Related Peptide (CGRP) Expression in Somatotroph Adenomas: Implications for Clinical Course and Treatment Outcomes.
NeuroendocrinologyThe Journey of Acromegaly Towards Treatment: A Single-Center Study.
Journal of personalized medicineHypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024).
Journal of veterinary internal medicineOwner points of view and perceived quality of life of diabetic cats pre- and post-hypophysectomy for hypersomatotropism.
Journal of veterinary internal medicineThe relationship between acromegaly and hepatic steatosis: insights from FibroScan imaging.
Journal of endocrinological investigationAcromegaly presenting with normal insulin-like growth factor-1 levels in a patient with advanced liver cirrhosis.
BMJ case reportsGrowth hormone causes reversible fibrosis in muscle and fat: a study in patients with acromegaly.
European journal of endocrinologyAcromegaly-induced dilated cardiomyopathy presenting with heart failure as the cardinal symptom: A case report.
SAGE open medical case reportsLATE DIAGNOSIS OF ACROMEGALY IN THE SETTING OF A SOMATOPROLACTINOMA.
Georgian medical newsRichard "Dicky" Dickinson (1669-1739) - satirical prints and probable acromegaly.
Journal of endocrinological investigationAnterior scleral thickness in acromegaly: a prospective multimeridional optical coherence tomography analysis.
BMC ophthalmologyHistory Page: Leaders in MSK Radiology Howard L. Steinbach, MD (1918-1996).
Seminars in musculoskeletal radiologyAcrochordons: A clue for MEN1-associated acromegaly.
The American journal of medicineA Medically Managed Case of Acromegaly: A Case Report.
CureusGamma knife radiosurgery vs fractionated radiotherapy : gender difference in efficacy and toxicity.
PituitarySex-related differences in healthcare utilization and costs among patients with pituitary adenomas.
PituitaryEndocrine Hypertension: The Role of Imaging in Diagnosis and Management.
The British journal of radiologyDecoy Lesion in Functional Multiple Pituitary Adenomas: Literature Review and Illustrative Cases on Diagnostic Pitfalls and Surgical Strategies.
World neurosurgeryClinical characteristics associated with somatic GNAS mutations in acromegaly: a systematic review and institutional experience.
Frontiers in endocrinologyImpact of sex on mortality in patients with pituitary adenomas.
PituitaryCavernous Sinus Medial Wall Resection: A Retrospective Single-Institution Study on Outcomes in Functional Pituitary Adenomas.
Operative neurosurgery (Hagerstown, Md.)Growth Hormone, Not Simply Just a Hormone for Growth.
Endocrinology and metabolism (Seoul, Korea)A Case Report of Growth Hormone-Secreting Pituitary Adenoma Complicated by Apoplexy With Atypical Clinical Presentation.
Case reports in medicineLugol's solution for preoperative management of a TSH/GH-secreting pituitary adenoma with suboptimal response to octreotide: a case report.
Frontiers in endocrinologyCardiovascular Effects of Growth Hormone: From Deficiency to Acromegaly.
Cardiology in reviewMixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients.
Acta neuropathologica communicationsDetection of Acromegaly From Facial Images Using Machine Learning: A Comparison With Clinical Experts.
Journal of the Endocrine SocietySerum Lipidomic Profile Signature of Active Acromegaly and Relationships to Cardiovascular Disease.
International journal of molecular sciencesCraniofacial and Radiological Features as Diagnostic Clues to Unmask Acromegaly: A Case Report.
CureusEctopic Acromegaly Caused by Peripheral Ectopic Growth Hormone Hypersecretion: A Case Report and Literature Review.
CureusGender differences in the glycometabolic and cardiovascular features of acromegaly.
PituitaryImportance of the early diagnosis of acromegaly. Evolution of mandibular growth and dental occlusion in a case with a late diagnosis.
Journal of clinical and experimental dentistryEndoscopic Endonasal Transsphenoidal Surgery (EETS) for PitNETs: Outcomes in a Single Institution Over a Decade.
Neuro endocrinology lettersPaltusotine and Its Place in the Treatment Armamentarium for Acromegaly.
The Journal of clinical endocrinology and metabolismLong-term effect on bone mineral density of denosumab in the treatment of hyperpituitarism driven osteoporosis: an exploratory study.
PituitaryReappraisal of colorectal polyps in acromegaly: study on prevalence, recurrence and risk factors.
PituitaryPachydermoperiostosis Presenting With Gynecomastia and Low Insulin-Like Growth Factor-1 Levels: A Diagnostic Challenge.
CureusPreoperative medical therapy for acromegaly: current knowledge and clinical significance.
Frontiers in endocrinologyAltered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing.
CNS neuroscience & therapeuticsPatients With Pituitary Neuroendocrine Tumours Requiring Neurosurgery -Who Is Referring Them?
Clinical endocrinologyAcromegaly Presenting With Cricoarytenoid Joint Arthropathy.
The LaryngoscopeCabergoline monotherapy in GH- and PRL-cosecreting pituitary adenomas.
Endocrine oncology (Bristol, England)Endoscopic Transsphenoidal Approach for the Treatment of Pituitary Adenoma Complicated With Rathke Cleft Cyst.
The Journal of craniofacial surgeryComparison of oral versus intravenous glucose exposure on plasma growth hormone levels: a crossover study in healthy volunteers.
PituitaryCost-effectiveness of pasireotide long-acting release in acromegaly: a systematic literature review and methodology assessment.
Journal of medical economicsSuccessful 15-year management of a 97-year-old woman with acromegaly: a case report and review of the literature.
Journal of medical case reportsA new era in oral treatment for acromegaly with the FDA-approved drug paltusotine.
Annals of medicine and surgery (2012)Acromegaly in an elderly male with hepatic malignancy: a case report of a diagnostic dilemma.
Annals of medicine and surgery (2012)Diagnostic and prognostic value of myocardial work indices in evaluating cardiac function damage in active acromegaly patients.
Endocrine connectionsEarly Postoperative Predictors of Remission After Transsphenoidal Surgery in Acromegaly: Introduction of the PARS.
Journal of the Endocrine SocietyAncient Schwannoma of the Submandibular Gland in a Patient With Acromegaly: A Case Report.
CureusImpact of Nutrition on Somatotroph Axis: A Potential Role in Acromegaly and Its Cardiovascular Risk?
Journal of the Endocrine SocietyMixed gangliocytoma-silent somatotroph pituitary adenoma: a rare variant with pregnancy-associated growth.
BMJ case reportsAssociation of Familial Adenomatous Polyposis With Classic Papillary Thyroid Carcinoma and Acromegaly: A Case Report.
AACE endocrinology and diabetesOral and gut microbiota after acromegaly treatment: prospective assessment and insights from machine learning.
PituitaryGrowth Hormone-Secreting Pituitary Macroadenoma: Diagnosis of Acromegaly in a Young Adult.
CureusAssessment of body composition in active and controlled acromegaly by bioelectrical impedance analysis and dual-energy x-ray absorptiometry.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research SocietyPsychological profiles of patients with acromegaly: personality traits, quality of life, and clinical correlates.
PituitaryPituitary Macroadenoma: A Conservative Approach to Apoplexy.
CureusChange in apnea hypopnea index and sleep quality following treatment in acromegaly.
Endocrine researchAuthor's reply to the Letter to the Editor by M Vijayasimha "Standardizing blood pressure phenotyping in acromegaly: a practical companion to Araujo-Castro et al.".
PituitaryFunctional analysis of AIP variants in a cohort of neuroendocrine neoplasms.
Endocrine-related cancerAnatomical considerations in acromegalic patients: A multicentric cohort study.
Surgical neurology internationalDevelopment of Marine-Lenhart Syndrome During the Course of Acromegaly. A Case Report.
Internal medicine (Tokyo, Japan)Standardizing blood pressure phenotyping in acromegaly: A practical companion to Araujo-Castro et al.
PituitaryLong-term clinical control in acromegaly patients with postoperative discordant nadir growth hormone during oral glucose tolerance test and insulin-like growth factor 1 levels: a retrospective observational study and literature review.
Langenbeck's archives of surgeryAssociation between vertebral fracture risk and bone mineral density in patients with acromegaly.
PituitaryFrom misclassified AIP variant to carney complex: a case report and retrospective evaluation of PRKAR1A in pituitary tumor predisposition.
PituitaryAnemia in acromegaly: Prevalence, etiologies, and predictors from a large tertiary center cohort.
PituitarySpontaneous regression of a growth hormone-secreting pituitary adenoma following thyroidectomy for toxic multinodular goiter with superior vena cava obstruction: Report of a rare case.
Medicine internationalPost-operative Outcomes of Pituitary Macroadenoma Patients in a Tertiary Hospital in the Philippines.
Journal of the ASEAN Federation of Endocrine SocietiesOsteoporosis and fragility fractures in patients with acromegaly: A two-center cross-sectional study.
World journal of orthopedicsOral mucosal health in acromegaly: clinical insights and metabolic associations.
BMC oral healthReal-world burden of disease, treatment, and healthcare resource utilization in acromegaly: a quantitative survey of patient experiences.
Journal of patient-reported outcomesDual Hormonal Presentation in a Rare Sellar Gangliocytoma: Diagnostic and Pathological Insights from a Collision Tumor.
Journal of neurological surgery reportsThe Long-Term Effects of Postoperative Radiotherapy in Acromegaly: Results From a Single-Center Acromegaly Registry in Iran.
International journal of endocrinologyGiant Prolactinoma Resistant to High-Dose Cabergoline in a Young Male Lost to Follow-Up.
CureusTumor characteristics and clinical outcomes in 113 patients with acromegaly: exploratory analysis of the role of histologic invasion of adjacent tissues.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaClinical dermatoendocrinology: saving lives by looking at the skin.
Archives of endocrinology and metabolismSubclinical myocardial dysfunction in pituitary neuroendocrine tumor patients: a 2D speckle-tracking echocardiography study.
Endocrine connectionsAortic Valve Annular Features in Acromegaly-A Detailed Three-Dimensional Speckle-Tracking Echocardiographic Analysis from the MAGYAR-Path Study.
Journal of clinical medicineClinical and Pathological Spectrum of Acromegaly: Distinguishing GH-PitNETs, Mammosomatotrophs and Mixed Tumors.
The Journal of clinical endocrinology and metabolismPaltusotine: First Approval.
DrugsDental Implantology in Acromegaly: Pathophysiological Challenges, Biomaterial Interactions, and Future Directions-A Narrative Review.
Journal of functional biomaterialsOctreotide ameliorates Bisphenol A-induced testicular toxicity via autophagy-inflammation pathway modulation.
Human & experimental toxicologyAcromegaly and breast cancer risk: evidence from a systematic review and meta-analysis.
Frontiers in endocrinologyComparative PET Imaging for Radiosurgical Target Delineation in Residual Acromegaly.
Journal of nuclear medicine : official publication, Society of Nuclear MedicineGH replacement therapy in adults stimulates fibroblast activation protein-α activity.
European journal of endocrinologyUse of Pasireotide in Acromegaly: Clinical Experiences From a Series of Patients in Qatar.
Case reports in endocrinologyAnesthetic Management for Pituitary Tumor Resection in a Patient With Acromegalic Cardiomyopathy: A Case Report.
Clinical case reportsClomiphene Citrate in Men With Hypogonadism-Do we Need to Monitor IGF-1 in All Patients?
Journal of the Endocrine SocietyExploring Brain Parenchymal Changes in Acromegaly: Focus on White Matter Hyperintensities.
Clinical endocrinologyImmunohistochemical analysis of filamin a expression in acromegaly and its correlation with tumor characteristics and treatment response.
Scientific reportsGrowing Pains: GH-induced Fibrosis Across Multiple Organs in bGH Mice.
EndocrinologyAcute Unprovoked Pulmonary Embolism As the First Presentation in Undiagnosed Acromegaly.
CureusAllostatic load index in patients with pituitary tumours: a case control study.
Frontiers in endocrinologyNeonatal Outcomes Following a Preconception Lifestyle Intervention in People at Risk of Gestational Diabetes: Secondary Findings from the BEFORE THE BEGINNING Randomized Controlled Trial.
NutrientsIncidence and risk factors for transient and permanent central diabetes insipidus following pituitary adenoma surgery: a single center study.
The International journal of neuroscienceGrowth hormone in disease and treatment (Review).
Medicine internationalCabergoline-Induced Gambling Causing Increased Adrenal Crisis Episodes.
JCEM case reportsCase Report: Bilateral lens dislocation as an atypical presentation of acromegaly and review of the ocular effects of GH/IGF-1 excess.
Frontiers in endocrinologyCorrigendum to: Patterns of Extraocular Muscle Enlargement in Graves' Orbitopathy and Acromegaly.
Thyroid : official journal of the American Thyroid AssociationHypersomatotropism in diabetic cats in Australia.
Journal of feline medicine and surgeryBone scintigraphy pattern in a patient diagnosed with acromegaly.
Quantitative imaging in medicine and surgeryAcromegaly treatment and bone: a bidirectional relationship.
PituitaryEarly Postoperative Decline in Insulin-Like Growth Factor 1 (IGF-1) Predicts Surgical Remission of Acromegaly.
World neurosurgeryCardiomyopathies of endocrine origin: A state-of-the-art review.
World journal of cardiologyCoexistence Tumor of Craniopharyngioma and Pituitary Neuroendocrine Tumor: A Case Report and Literature Review.
CureusPaltusotine: The first selective nonpeptide agonist of somatostatin receptor 2 (SSTR2) for the treatment of acromegaly.
Drug discoveries & therapeuticsPegvisomant in managing comorbidities of acromegaly: a review.
Reviews in endocrine & metabolic disordersSomatostatin analogs in endothelial dysfunction.
American journal of physiology. Endocrinology and metabolismHematological Malignancy in a Hypophysectomised Acromegalic Patient Under 4-Year Therapy with Somatostatin Analogues: From a Rib Lump Underlying Bone Plasmatocytoma Features to Multiple Myeloma.
Diagnostics (Basel, Switzerland)Medical treatment in acromegaly: a network meta-analysis.
European journal of endocrinologyPrevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly.
PituitaryThe effect of treatment with somatostatin analogs in children with neurofibromatosis type 1 and growth hormone excess.
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research SocietyBone Health in Acromegaly.
Endocrinology and metabolism clinics of North AmericaMedical Therapies for Acromegaly.
Endocrinology and metabolism clinics of North AmericaRapid and Sustained Response of Biochemically Uncontrolled Acromegaly to Once-daily Oral Paltusotine Treatment.
The Journal of clinical endocrinology and metabolismAcromegaly and Morris Syndrome: Description of a Clinical Case.
Endocrine, metabolic & immune disorders drug targetsSurgical Outcomes and Complications of Patients With Acromegaly in Qatar.
CureusDiagnostic Delay in Acromegaly Due to Overlapping Features With Polycystic Ovary Syndrome: A Case Report.
CureusGrowth Hormone Assay-Adjusted Standardization Reveals Distinct Clinical Phenotypes in Acromegaly.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical EndocrinologistsExercise ventilatory inefficiency may be a specific feature of patients with acromegaly.
PituitaryEndocrinology and the Lung: Exploring the Bidirectional Axis and Future Directions.
Journal of clinical medicineEffects of Hormones on Left Heart Structure and Function with Echocardiography in Acromegaly.
Reviews in cardiovascular medicineSAGIT®, ACRODAT®, PANOMEN 3… time to implement tools for management of acromegaly..?
PituitaryImpact of GH and IGF-I excess on nervous and vascular retinal structure in newly diagnosed acromegaly patients.
PituitaryGIPR in GH-PitNETs: molecular and functional insights.
Endocrine-related cancerA Case of Acromegaly With Parasellar Meningioma With Oculomotor Palsy Responding to and Maintained With Oral Octreotide Therapy.
AACE endocrinology and diabetesGrowth hormone excess drives liver aging via increased glycation stress.
AgingPossibility of calcification of type I collagen matrix in growth hormone-secreting pituitary neuroendocrine tumor.
Surgical neurology internationalBasilar artery vasospasm following transsphenoidal resection of recurrent pituitary macroadenoma: illustrative case.
Journal of neurosurgery. Case lessonsPotential role of insulin-like growth factor 1 and growth hormone in acneiform eruptions: evidence from a rat model of acromegaly.
Journal of endocrinological investigationPersonalized medicine in acromegaly: insights from the ACROFAST clinical trial.
Expert review of endocrinology & metabolism[Spontaneous remission of neuroendocrine diseases due to apoplexy in hormonally active pituitary adenomas].
Problemy endokrinologiiInsulin-like growth factor-I and symptoms of acromegaly according to time since somatostatin receptor ligand injection.
European journal of endocrinologyThe Evaluation of Retinal, Choroidal, Scleral, and Optic Disc Parameters in Acromegaly.
Ophthalmic surgery, lasers & imaging retinaThoracic ultrasonography and pulmonary function tests in assessing lung function in acromegaly: a prospective matched case-control study.
Monaldi archives for chest disease = Archivio Monaldi per le malattie del toraceThe Resolution of Photophobia and Short-Lasting Unilateral Neuralgiform Headache Attacks with Conjunctival Injection and Tearing (SUNCT) Subsequent to Growth Hormone Adenoma Resection: Elucidating the Proposed Pathophysiological Mechanisms.
Neuro-ophthalmology (Aeolus Press)Long-term antitumour effects of pasireotide in acromegaly.
European journal of endocrinologyIdiopathic central sleep apnea: the past, the present, and the future.
SleepOutcome of acromegalic patients undergoing endoscopic endonasal surgery: collaborative French and Italian cohort, a 25-year experience.
Neurosurgical reviewMetabolic Factors Related to Interpersonal Dysfunction in Acromegaly: A Nationwide Cross-Sectional Study in China.
CNS neuroscience & therapeuticsRevisiting mortality in acromegaly using machine learning.
EndocrineFrom Subtle Signs to Severe Sequelae-A Century of Symptomatology and Comorbidities in the Diagnosis of GH-Secreting Pituitary Neuroendocrine Tumors: A Systematic Review.
Diagnostics (Basel, Switzerland)Development of lateral flow assay for quantitative analysis of growth hormone.
TalantaSilent growth hormone pituitary adenomas: a single-center study.
PituitaryTime restricted eating and exercise training before and during pregnancy for people with increased risk of gestational diabetes: single centre randomised controlled trial (BEFORE THE BEGINNING).
BMJ (Clinical research ed.)Disease-Specific Mortality in Patients With Acromegaly Treated With Pegvisomant: An ACROSTUDY Analysis.
Endocrine connectionsNICTH with secondary acromegaloid changes and severe hypoglycemia due to potentially insulin-like growth factor-2 mediated effects.
Journal of diabetes and metabolic disordersThe clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort.
PituitaryEcchordosis Physaliphora: A Rare and Challenging Clinical Entity in a Patient With Acromegaly.
JCEM case reportsComparison of triglyceride-glucose index and HOMA-IR in assessing insulin resistance in acromegaly: a case-control study.
Endokrynologia PolskaSclerostin levels in patients with acromegaly.
Endokrynologia PolskaSupramolecular Microspheres Fabricated from Macrocycle-Incorporated Polymers and Their Biomedical Applications Based on Host-Guest Recognition.
Small methodsAdherence, duration and healthcare costs in a real-world population of patients with acromegaly.
Journal of comparative effectiveness researchAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Associação brasileira dedicada a Mucopolissacaridoses.
Associação brasileira dedicada a Acromegalia.
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Acromegalia
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Perguntas, dicas e experiências compartilhadas aqui na página
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Neuropsychological profile in acromegaly: a single center cross sectional analysis and preliminary prospective long-term study.
- Case Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.
- Acromegaly presenting with normal insulin-like growth factor-1 levels in a patient with advanced liver cirrhosis.
- Serum Lipidomic Profile Signature of Active Acromegaly and Relationships to Cardiovascular Disease.
- Altered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing.
- The Many Faces of Acromegaly: Understanding Its Clinical and Biological Heterogeneity.
- Disease-related burden and treatment experience in patients with acromegaly: a gender perspective.
- Long-term safety and efficacy of pegvisomant monotherapy for acromegaly: final data from the full ACROSTUDY cohort.
- Current Controversies in Acromegaly Care.
- Acromegaly in an Elderly Woman.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:963(Orphanet)
- MONDO:0019933(MONDO)
- Acromegalia(PCDT · Ministério da Saúde)
- GARD:5725(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q189580(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
