Raras
Buscar doenças, sintomas, genes...
Acromegalia
ORPHA:963CID-10 · E22.0CID-11 · 5A60.0PCDT · SUSDOENÇA RARA

Acromegalia é uma doença adquirida, causada pela produção excessiva do hormônio do crescimento (GH). Ela se manifesta por alterações progressivas no corpo (principalmente no rosto, mãos e pés) e outros problemas que afetam o organismo inteiro.

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Introdução

O que você precisa saber de cara

📋

Acromegalia é uma doença adquirida, causada pela produção excessiva do hormônio do crescimento (GH). Ela se manifesta por alterações progressivas no corpo (principalmente no rosto, mãos e pés) e outros problemas que afetam o organismo inteiro.

Pesquisas ativas
17 ensaios
201 total registrados no ClinicalTrials.gov
Publicações científicas
10.216 artigos
Último publicado: 2026 Apr 16

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-9 / 100 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
3.6
Spain
Início
Adolescent
+ adult, childhood, elderly, infancy
🏥
SUS: Cobertura parcialScore: 50%
PCDT disponível4 medicamentos CEAFCID-10: E22.0
Você se identifica com essa condição?
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

📏
Crescimento
15 sintomas
🦴
Ossos e articulações
7 sintomas
😀
Face
6 sintomas
🧬
Pele e cabelo
5 sintomas
🧠
Neurológico
4 sintomas
❤️
Coração
4 sintomas

+ 45 sintomas em outras categorias

Características mais comuns

90%prev.
Dedo afilado
Muito frequente (99-80%)
90%prev.
Hiperidrose
Muito frequente (99-80%)
90%prev.
Crescimento excessivo acral
Muito frequente (99-80%)
90%prev.
Anormalidade do sistema endócrino
Muito frequente (99-80%)
90%prev.
Macrodactilia
Muito frequente (99-80%)
90%prev.
Traços faciais grosseiros
Muito frequente (99-80%)
93sintomas
Muito frequente (27)
Frequente (31)
Ocasional (35)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 93 características clínicas mais associadas, ordenadas por frequência.

Dedo afiladoTapered finger
Muito frequente (99-80%)90%
HiperidroseHyperhidrosis
Muito frequente (99-80%)90%
Crescimento excessivo acralAcral overgrowth
Muito frequente (99-80%)90%
Anormalidade do sistema endócrinoAbnormality of the endocrine system
Muito frequente (99-80%)90%
MacrodactiliaMacrodactyly
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico10.216PubMed
Últimos 10 anos200publicações
Pico2025103 papers
Linha do tempo
2026Hoje · 2026🧪 1991Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

2 genes identificados com associação a esta condição. Padrão de herança: Not applicable.

GPR101Probable G-protein coupled receptor 101Major susceptibility factor inTolerante
FUNÇÃO

Orphan receptor

LOCALIZAÇÃO

Cell membrane

MECANISMO DE DOENÇA

Pituitary adenoma 2, growth hormone-secreting

A form of pituitary adenoma, a neoplasm of the pituitary gland and one of the most common neuroendocrine tumors. Pituitary adenomas are clinically classified as functional and non-functional tumors, and manifest with a variety of features, including local invasion of surrounding structures and excessive hormone secretion. Functional pituitary adenomas are further classified by the type of hormone they secrete. PITA2 is a growth hormone-secreting benign neoplasm, also known as somatotropinoma. It clinically results in acromegaly, a condition characterized by coarse facial features, protruding jaw, and enlarged extremities. Excessive production of growth hormone in children or adolescents before the closure of epiphyses causes gigantism, a condition characterized by abnormally tall stature.

EXPRESSÃO TECIDUAL(Baixa expressão)
Brain Nucleus accumbens basal ganglia
4.1 TPM
Hipotálamo
0.8 TPM
Brain Caudate basal ganglia
0.8 TPM
Brain Putamen basal ganglia
0.3 TPM
Cérebro - Hemisfério cerebelar
0.2 TPM
OUTRAS DOENÇAS (2)
pituitary adenoma, growth hormone-secreting, 2acromegaly
HGNC:14963UniProt:Q96P66
AIPSmall ribosomal subunit protein bS22, mitochondrialMajor susceptibility factor inModerado
FUNÇÃO

May act as a negative regulator of Aurora-A kinase, by down-regulation through proteasome-dependent degradation

LOCALIZAÇÃO

Mitochondrion matrixNucleus

VIAS BIOLÓGICAS (2)
Aryl hydrocarbon receptor signallingGene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
OUTRAS DOENÇAS (7)
growth hormone secreting pituitary adenoma 1familial isolated pituitary adenomapituitary gigantismsilent pituitary adenoma
HGNC:358UniProt:Q9NWT8

Medicamentos aprovados (FDA)

3 medicamentos encontrados nos registros da FDA americana.

💊 Octreotide Acetate (OCTREOTIDE ACETATE)
💊 Bromocriptine mesylate (BROMOCRIPTINE MESYLATE)
💊 Lanreotide Acetate (LANREOTIDE ACETATE)
Ver no DailyMed/FDA

Variantes genéticas (ClinVar)

392 variantes patogênicas registradas no ClinVar.

🧬 GPR101: GRCh37/hg19 Xq23-28(chrX:113417246-155233731)x1 ()
🧬 GPR101: GRCh37/hg19 Xq13.1-27.1(chrX:71017904-140066710)x4 ()
🧬 GPR101: GRCh37/hg19 Xq26.3(chrX:135570201-136357524)x2 ()
🧬 GPR101: GRCh37/hg19 Xq26.3-28(chrX:134810076-155258261)x1 ()
🧬 GPR101: GRCh38/hg38 Xp22.33-q28(chrX:2757837-156030895)x2 ()
Ver todas no ClinVar

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 34
2Fase 22
1Fase 11
·Pré-clínico13
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Acromegalia

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

12 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

201 ensaios clínicos encontrados, 17 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
3.290 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 3.290

#1

Neuropsychological profile in acromegaly: a single center cross sectional analysis and preliminary prospective long-term study.

Frontiers in neurology2026

Este estudo revela que pacientes com acromegalia frequentemente apresentam transtornos de ansiedade (35%) e depressão (23%), predominantemente naqueles com doença ativa, e demonstram um desempenho neurocognitivo significativamente inferior em áreas como memória e atenção, comparado a indivíduos saudáveis. Níveis elevados de IGF-1 e hipopituitarismo foram associados a um pior desempenho cognitivo. Para pacientes e médicos, isso significa a importância de monitorar e abordar tanto o bem-estar psicológico quanto a função cognitiva, pois o controle da atividade da doença pode estar ligado a uma melhora global a longo prazo nesses domínios.

🇧🇷 traduzido
#2

Case Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.

Frontiers in veterinary science2026

Este caso descreve um cão diabético com acromegalia (excesso de hormônio do crescimento devido a um tumor hipofisário), que causava diabetes de difícil controle e resistência à insulina. Embora a cirurgia para remover o tumor tenha normalizado com sucesso os níveis hormonais (GH e IGF-1), o diabetes e a necessidade de insulina persistiram, culminando na eutanásia do animal cerca de 9 meses depois. Isso destaca que, apesar da eficácia da cirurgia na correção hormonal, o diabetes pode não se reverter completamente, um ponto crucial para médicos veterinários e tutores considerarem no manejo desta condição.

🇧🇷 traduzido
#3

Acromegaly presenting with normal insulin-like growth factor-1 levels in a patient with advanced liver cirrhosis.

BMJ case reports2026 Feb 19

Este caso demonstra que a acromegalia pode se apresentar com níveis normais do fator de crescimento IGF-1 em pacientes com cirrose hepática avançada, devido ao papel vital do fígado na produção de IGF-1. Nesses casos, é crucial que médicos se guiem pelos sintomas clínicos, exames como o de supressão de GH e julgamento clínico, pois a disfunção hepática pode mascarar a doença. Isso é importante para pacientes e médicos para evitar o subdiagnóstico da acromegalia em indivíduos com doença hepática.

🇧🇷 traduzido
#4

Serum Lipidomic Profile Signature of Active Acromegaly and Relationships to Cardiovascular Disease.

International journal of molecular sciences2026 Jan 21

Este estudo revelou que pacientes com acromegalia ativa apresentam um perfil lipídico sanguíneo alterado, destacando a esfingomielina SM 34:0;O2 e a fosforilcolina como potenciais biomarcadores que podem diferenciar a doença e indicar sua gravidade, especialmente em casos não tratados. Além disso, foram identificadas alterações lipídicas específicas associadas a complicações cardiovasculares, como hipertensão e insuficiência cardíaca, fornecendo aos médicos novas ferramentas para avaliar o risco e aos pacientes uma compreensão mais profunda da ligação entre a acromegalia e a saúde do coração.

🇧🇷 traduzido
#5

Altered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing.

CNS neuroscience &amp; therapeutics2026 Jan

Este estudo revelou que pacientes com acromegalia apresentam alterações significativas na função e conectividade de redes cerebrais ligadas à cognição e emoção, resultando em menor desempenho cognitivo. Para médicos, as mudanças detectadas por ressonância magnética funcional (fMRI) podem classificar pacientes com alta precisão (85.11%), oferecendo uma ferramenta promissora para diagnóstico e monitoramento. Para pacientes, isso explica as dificuldades cognitivas e emocionais associadas ao excesso de hormônio do crescimento no cérebro.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC6.824 artigos no totalmostrando 189

2026

Clinicopathological analysis of 19 cases of mixed gangliocytoma-pituitary neuroendocrine tumors.

Diagnostic pathology
2026

PPAR-α activator pemafibrate lowered plasma insulin-like growth factor-1 level in a patient with acromegaly.

Endocrinology, diabetes &amp; metabolism case reports
2026

Disease burden, treatment experiences and preferences in patients with acromegaly: a qualitative study.

Frontiers in endocrinology
2026

CAVERNOUS SINUS MEDIAL WALL RESECTION IN INVASIVE PITUITARY ADENOMAS: OUTCOME IN ACROMEGALY.

World neurosurgery
2026

Lumbar spinal stenosis in patients with acromegaly: an MRI-based case-control study.

World neurosurgery
2026

JAK2 inhibition with baricitinib stunts growth and postnatal development in juvenile rats.

Biomedicine &amp; pharmacotherapy = Biomedecine &amp; pharmacotherapie
2026

Synthetic somatostatin analogs ameliorate endothelial injury due to hydrochloric acid treatment.

Environmental toxicology and pharmacology
2026

Neuropsychological profile in acromegaly: a single center cross sectional analysis and preliminary prospective long-term study.

Frontiers in neurology
2026

Ageing and pituitary neuroendocrine tumours (PitNETs): from bench to bedside.

Endocrine-related cancer
2026

Anti-secretory and anti-proliferative actions of next-generation dual subtype 2 and 5 somatostatin receptor ligands in neuroendocrine tumor models.

Frontiers in oncology
2026

A Cross-Sectional Analysis of Musculoskeletal and Functional Outcomes in Patients with Pituitary Disorders: Frailty and Sarcopenia.

Journal of clinical medicine
2026

Pathogenesis of Non-Familial Somatotroph Adenomas.

The Journal of clinical endocrinology and metabolism
2026

Progression of acromegalic joint and psychological complications according to sex, treatments, and disease control.

European journal of endocrinology
2026

Case Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.

Frontiers in veterinary science
2026

[Guidelines for the diagnosis and treatment of obstructive sleep apnea in adults (2025)].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases
2026

Cytokeratin 5.2 expression as a predictive marker of outcome in patients with acromegaly following endoscopic transsphenoidal surgery.

Pituitary
2026

Quality of life questionnaires in patients with acromegaly: a scoping review.

Journal of patient-reported outcomes
2026

Impact of pain on quality of life (QoL) in patients with acromegaly: profound differences in physical and mental aspects of QoL.

Endocrine
2026

Thyroid cancer and thyroid nodules in acromegaly: a single-center retrospective study.

Endocrine
2026

Risk of cerebrovascular and cardiovascular events in acromegaly: a systematic review and meta-analysis.

Endocrine
2026

Cost-effectiveness of personalized medical treatment in acromegaly: a post hoc analysis of the ACROFAST study.

Journal of the Endocrine Society
2026

Evaluation of static and dynamic pupil responses in patients with acromegaly with automatic pupillometer.

BMC ophthalmology
2026

The clinical value of [18F]-fluoro-ethyl-L-tyrosine PET ([18F]FET-PET) correlated with MRI in patients with functioning pituitary adenomas: an observational cohort study.

Pituitary
2026

Sex differences in the clinical presentation, management and long-term outcomes of pituitary tumors in children and adolescents.

Pituitary
2026

Paltusotine: The first FDA approved oral treatment for acromegaly.

Annals of medicine and surgery (2012)
2026

Anesthetic management of a patient with McCune-Albright syndrome complicated by pathological cervical fracture: a case report.

BMC anesthesiology
2026

Distribution, Severity and Management of Joint Pain in Patients with Acromegaly.

European journal of endocrinology
2026

Efficacy and Safety of Pharmacologic Therapies in Acromegaly: A Systematic Literature Review and Network Meta-Analysis.

The Journal of clinical endocrinology and metabolism
2026

A QbD-informed study of permeation enhancer-octreotide nanoscale interactions influencing performance in pullulan buccal films.

International journal of pharmaceutics
2026

Clinical performance of an IGF1 LC-MS/MS assay and associated normative dataset in routine endocrinology.

European journal of endocrinology
2026

Prevalence and clinical correlates of pre-operative glucose homeostasis in patients with acromegaly.

Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2026

Automatic acromegaly detection using deep learning on hand images: a multicenter observational study.

The Journal of clinical endocrinology and metabolism
2026

Cancer Risk in Patients with Acromegaly: Insights from a Single Center in Ankara.

Journal of clinical medicine
2026

Calcitonin Gene-Related Peptide (CGRP) Expression in Somatotroph Adenomas: Implications for Clinical Course and Treatment Outcomes.

Neuroendocrinology
2026

The Journey of Acromegaly Towards Treatment: A Single-Center Study.

Journal of personalized medicine
2026

Hypersomatotropism without concurrent diabetes mellitus in cats: 28 cases (2014-2024).

Journal of veterinary internal medicine
2026

Owner points of view and perceived quality of life of diabetic cats pre- and post-hypophysectomy for hypersomatotropism.

Journal of veterinary internal medicine
2026

The relationship between acromegaly and hepatic steatosis: insights from FibroScan imaging.

Journal of endocrinological investigation
2026

Acromegaly presenting with normal insulin-like growth factor-1 levels in a patient with advanced liver cirrhosis.

BMJ case reports
2026

Growth hormone causes reversible fibrosis in muscle and fat: a study in patients with acromegaly.

European journal of endocrinology
2026

Acromegaly-induced dilated cardiomyopathy presenting with heart failure as the cardinal symptom: A case report.

SAGE open medical case reports
2025

LATE DIAGNOSIS OF ACROMEGALY IN THE SETTING OF A SOMATOPROLACTINOMA.

Georgian medical news
2026

Richard "Dicky" Dickinson (1669-1739) - satirical prints and probable acromegaly.

Journal of endocrinological investigation
2026

Anterior scleral thickness in acromegaly: a prospective multimeridional optical coherence tomography analysis.

BMC ophthalmology
2026

History Page: Leaders in MSK Radiology Howard L. Steinbach, MD (1918-1996).

Seminars in musculoskeletal radiology
2026

Acrochordons: A clue for MEN1-associated acromegaly.

The American journal of medicine
2026

A Medically Managed Case of Acromegaly: A Case Report.

Cureus
2026

Gamma knife radiosurgery vs fractionated radiotherapy : gender difference in efficacy and toxicity.

Pituitary
2026

Sex-related differences in healthcare utilization and costs among patients with pituitary adenomas.

Pituitary
2026

Endocrine Hypertension: The Role of Imaging in Diagnosis and Management.

The British journal of radiology
2026

Decoy Lesion in Functional Multiple Pituitary Adenomas: Literature Review and Illustrative Cases on Diagnostic Pitfalls and Surgical Strategies.

World neurosurgery
2026

Clinical characteristics associated with somatic GNAS mutations in acromegaly: a systematic review and institutional experience.

Frontiers in endocrinology
2026

Impact of sex on mortality in patients with pituitary adenomas.

Pituitary
2026

Cavernous Sinus Medial Wall Resection: A Retrospective Single-Institution Study on Outcomes in Functional Pituitary Adenomas.

Operative neurosurgery (Hagerstown, Md.)
2026

Growth Hormone, Not Simply Just a Hormone for Growth.

Endocrinology and metabolism (Seoul, Korea)
2026

A Case Report of Growth Hormone-Secreting Pituitary Adenoma Complicated by Apoplexy With Atypical Clinical Presentation.

Case reports in medicine
2025

Lugol's solution for preoperative management of a TSH/GH-secreting pituitary adenoma with suboptimal response to octreotide: a case report.

Frontiers in endocrinology
2026

Cardiovascular Effects of Growth Hormone: From Deficiency to Acromegaly.

Cardiology in review
2026

Mixed gangliocytoma-pituitary neuroendocrine tumour: clinical, immunohistochemical, and molecular genetic profiles in a series of four patients.

Acta neuropathologica communications
2026

Detection of Acromegaly From Facial Images Using Machine Learning: A Comparison With Clinical Experts.

Journal of the Endocrine Society
2026

Serum Lipidomic Profile Signature of Active Acromegaly and Relationships to Cardiovascular Disease.

International journal of molecular sciences
2025

Craniofacial and Radiological Features as Diagnostic Clues to Unmask Acromegaly: A Case Report.

Cureus
2025

Ectopic Acromegaly Caused by Peripheral Ectopic Growth Hormone Hypersecretion: A Case Report and Literature Review.

Cureus
2026

Gender differences in the glycometabolic and cardiovascular features of acromegaly.

Pituitary
2025

Importance of the early diagnosis of acromegaly. Evolution of mandibular growth and dental occlusion in a case with a late diagnosis.

Journal of clinical and experimental dentistry
2025

Endoscopic Endonasal Transsphenoidal Surgery (EETS) for PitNETs: Outcomes in a Single Institution Over a Decade.

Neuro endocrinology letters
2026

Paltusotine and Its Place in the Treatment Armamentarium for Acromegaly.

The Journal of clinical endocrinology and metabolism
2026

Long-term effect on bone mineral density of denosumab in the treatment of hyperpituitarism driven osteoporosis: an exploratory study.

Pituitary
2026

Reappraisal of colorectal polyps in acromegaly: study on prevalence, recurrence and risk factors.

Pituitary
2025

Pachydermoperiostosis Presenting With Gynecomastia and Low Insulin-Like Growth Factor-1 Levels: A Diagnostic Challenge.

Cureus
2025

Preoperative medical therapy for acromegaly: current knowledge and clinical significance.

Frontiers in endocrinology
2026

Altered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing.

CNS neuroscience &amp; therapeutics
2026

Patients With Pituitary Neuroendocrine Tumours Requiring Neurosurgery -Who Is Referring Them?

Clinical endocrinology
2026

Acromegaly Presenting With Cricoarytenoid Joint Arthropathy.

The Laryngoscope
2026

Cabergoline monotherapy in GH- and PRL-cosecreting pituitary adenomas.

Endocrine oncology (Bristol, England)
2026

Endoscopic Transsphenoidal Approach for the Treatment of Pituitary Adenoma Complicated With Rathke Cleft Cyst.

The Journal of craniofacial surgery
2026

Comparison of oral versus intravenous glucose exposure on plasma growth hormone levels: a crossover study in healthy volunteers.

Pituitary
2026

Cost-effectiveness of pasireotide long-acting release in acromegaly: a systematic literature review and methodology assessment.

Journal of medical economics
2026

Successful 15-year management of a 97-year-old woman with acromegaly: a case report and review of the literature.

Journal of medical case reports
2026

A new era in oral treatment for acromegaly with the FDA-approved drug paltusotine.

Annals of medicine and surgery (2012)
2026

Acromegaly in an elderly male with hepatic malignancy: a case report of a diagnostic dilemma.

Annals of medicine and surgery (2012)
2026

Diagnostic and prognostic value of myocardial work indices in evaluating cardiac function damage in active acromegaly patients.

Endocrine connections
2026

Early Postoperative Predictors of Remission After Transsphenoidal Surgery in Acromegaly: Introduction of the PARS.

Journal of the Endocrine Society
2025

Ancient Schwannoma of the Submandibular Gland in a Patient With Acromegaly: A Case Report.

Cureus
2026

Impact of Nutrition on Somatotroph Axis: A Potential Role in Acromegaly and Its Cardiovascular Risk?

Journal of the Endocrine Society
2025

Mixed gangliocytoma-silent somatotroph pituitary adenoma: a rare variant with pregnancy-associated growth.

BMJ case reports
2025

Association of Familial Adenomatous Polyposis With Classic Papillary Thyroid Carcinoma and Acromegaly: A Case Report.

AACE endocrinology and diabetes
2025

Oral and gut microbiota after acromegaly treatment: prospective assessment and insights from machine learning.

Pituitary
2025

Growth Hormone-Secreting Pituitary Macroadenoma: Diagnosis of Acromegaly in a Young Adult.

Cureus
2026

Assessment of body composition in active and controlled acromegaly by bioelectrical impedance analysis and dual-energy x-ray absorptiometry.

Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2025

Psychological profiles of patients with acromegaly: personality traits, quality of life, and clinical correlates.

Pituitary
2025

Pituitary Macroadenoma: A Conservative Approach to Apoplexy.

Cureus
2026

Change in apnea hypopnea index and sleep quality following treatment in acromegaly.

Endocrine research
2025

Author's reply to the Letter to the Editor by M Vijayasimha "Standardizing blood pressure phenotyping in acromegaly: a practical companion to Araujo-Castro et al.".

Pituitary
2026

Functional analysis of AIP variants in a cohort of neuroendocrine neoplasms.

Endocrine-related cancer
2025

Anatomical considerations in acromegalic patients: A multicentric cohort study.

Surgical neurology international
2025

Development of Marine-Lenhart Syndrome During the Course of Acromegaly. A Case Report.

Internal medicine (Tokyo, Japan)
2025

Standardizing blood pressure phenotyping in acromegaly: A practical companion to Araujo-Castro et al.

Pituitary
2025

Long-term clinical control in acromegaly patients with postoperative discordant nadir growth hormone during oral glucose tolerance test and insulin-like growth factor 1 levels: a retrospective observational study and literature review.

Langenbeck's archives of surgery
2025

Association between vertebral fracture risk and bone mineral density in patients with acromegaly.

Pituitary
2025

From misclassified AIP variant to carney complex: a case report and retrospective evaluation of PRKAR1A in pituitary tumor predisposition.

Pituitary
2025

Anemia in acromegaly: Prevalence, etiologies, and predictors from a large tertiary center cohort.

Pituitary
2026

Spontaneous regression of a growth hormone-secreting pituitary adenoma following thyroidectomy for toxic multinodular goiter with superior vena cava obstruction: Report of a rare case.

Medicine international
2025

Post-operative Outcomes of Pituitary Macroadenoma Patients in a Tertiary Hospital in the Philippines.

Journal of the ASEAN Federation of Endocrine Societies
2025

Osteoporosis and fragility fractures in patients with acromegaly: A two-center cross-sectional study.

World journal of orthopedics
2025

Oral mucosal health in acromegaly: clinical insights and metabolic associations.

BMC oral health
2025

Real-world burden of disease, treatment, and healthcare resource utilization in acromegaly: a quantitative survey of patient experiences.

Journal of patient-reported outcomes
2025

Dual Hormonal Presentation in a Rare Sellar Gangliocytoma: Diagnostic and Pathological Insights from a Collision Tumor.

Journal of neurological surgery reports
2025

The Long-Term Effects of Postoperative Radiotherapy in Acromegaly: Results From a Single-Center Acromegaly Registry in Iran.

International journal of endocrinology
2025

Giant Prolactinoma Resistant to High-Dose Cabergoline in a Young Male Lost to Follow-Up.

Cureus
2026

Tumor characteristics and clinical outcomes in 113 patients with acromegaly: exploratory analysis of the role of histologic invasion of adjacent tissues.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2025

Clinical dermatoendocrinology: saving lives by looking at the skin.

Archives of endocrinology and metabolism
2025

Subclinical myocardial dysfunction in pituitary neuroendocrine tumor patients: a 2D speckle-tracking echocardiography study.

Endocrine connections
2025

Aortic Valve Annular Features in Acromegaly-A Detailed Three-Dimensional Speckle-Tracking Echocardiographic Analysis from the MAGYAR-Path Study.

Journal of clinical medicine
2025

Clinical and Pathological Spectrum of Acromegaly: Distinguishing GH-PitNETs, Mammosomatotrophs and Mixed Tumors.

The Journal of clinical endocrinology and metabolism
2026

Paltusotine: First Approval.

Drugs
2025

Dental Implantology in Acromegaly: Pathophysiological Challenges, Biomaterial Interactions, and Future Directions-A Narrative Review.

Journal of functional biomaterials
2025

Octreotide ameliorates Bisphenol A-induced testicular toxicity via autophagy-inflammation pathway modulation.

Human &amp; experimental toxicology
2025

Acromegaly and breast cancer risk: evidence from a systematic review and meta-analysis.

Frontiers in endocrinology
2026

Comparative PET Imaging for Radiosurgical Target Delineation in Residual Acromegaly.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine
2025

GH replacement therapy in adults stimulates fibroblast activation protein-α activity.

European journal of endocrinology
2025

Use of Pasireotide in Acromegaly: Clinical Experiences From a Series of Patients in Qatar.

Case reports in endocrinology
2025

Anesthetic Management for Pituitary Tumor Resection in a Patient With Acromegalic Cardiomyopathy: A Case Report.

Clinical case reports
2025

Clomiphene Citrate in Men With Hypogonadism-Do we Need to Monitor IGF-1 in All Patients?

Journal of the Endocrine Society
2026

Exploring Brain Parenchymal Changes in Acromegaly: Focus on White Matter Hyperintensities.

Clinical endocrinology
2025

Immunohistochemical analysis of filamin a expression in acromegaly and its correlation with tumor characteristics and treatment response.

Scientific reports
2025

Growing Pains: GH-induced Fibrosis Across Multiple Organs in bGH Mice.

Endocrinology
2025

Acute Unprovoked Pulmonary Embolism As the First Presentation in Undiagnosed Acromegaly.

Cureus
2025

Allostatic load index in patients with pituitary tumours: a case control study.

Frontiers in endocrinology
2025

Neonatal Outcomes Following a Preconception Lifestyle Intervention in People at Risk of Gestational Diabetes: Secondary Findings from the BEFORE THE BEGINNING Randomized Controlled Trial.

Nutrients
2025

Incidence and risk factors for transient and permanent central diabetes insipidus following pituitary adenoma surgery: a single center study.

The International journal of neuroscience
2025

Growth hormone in disease and treatment (Review).

Medicine international
2025

Cabergoline-Induced Gambling Causing Increased Adrenal Crisis Episodes.

JCEM case reports
2025

Case Report: Bilateral lens dislocation as an atypical presentation of acromegaly and review of the ocular effects of GH/IGF-1 excess.

Frontiers in endocrinology
2025

Corrigendum to: Patterns of Extraocular Muscle Enlargement in Graves' Orbitopathy and Acromegaly.

Thyroid : official journal of the American Thyroid Association
2025

Hypersomatotropism in diabetic cats in Australia.

Journal of feline medicine and surgery
2025

Bone scintigraphy pattern in a patient diagnosed with acromegaly.

Quantitative imaging in medicine and surgery
2025

Acromegaly treatment and bone: a bidirectional relationship.

Pituitary
2026

Early Postoperative Decline in Insulin-Like Growth Factor 1 (IGF-1) Predicts Surgical Remission of Acromegaly.

World neurosurgery
2025

Cardiomyopathies of endocrine origin: A state-of-the-art review.

World journal of cardiology
2025

Coexistence Tumor of Craniopharyngioma and Pituitary Neuroendocrine Tumor: A Case Report and Literature Review.

Cureus
2025

Paltusotine: The first selective nonpeptide agonist of somatostatin receptor 2 (SSTR2) for the treatment of acromegaly.

Drug discoveries &amp; therapeutics
2025

Pegvisomant in managing comorbidities of acromegaly: a review.

Reviews in endocrine &amp; metabolic disorders
2025

Somatostatin analogs in endothelial dysfunction.

American journal of physiology. Endocrinology and metabolism
2025

Hematological Malignancy in a Hypophysectomised Acromegalic Patient Under 4-Year Therapy with Somatostatin Analogues: From a Rib Lump Underlying Bone Plasmatocytoma Features to Multiple Myeloma.

Diagnostics (Basel, Switzerland)
2025

Medical treatment in acromegaly: a network meta-analysis.

European journal of endocrinology
2025

Prevalence and evolution of hypertension in a large Iberian cohort of patients with acromegaly.

Pituitary
2025

The effect of treatment with somatostatin analogs in children with neurofibromatosis type 1 and growth hormone excess.

Growth hormone &amp; IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
2025

Bone Health in Acromegaly.

Endocrinology and metabolism clinics of North America
2025

Medical Therapies for Acromegaly.

Endocrinology and metabolism clinics of North America
2026

Rapid and Sustained Response of Biochemically Uncontrolled Acromegaly to Once-daily Oral Paltusotine Treatment.

The Journal of clinical endocrinology and metabolism
2025

Acromegaly and Morris Syndrome: Description of a Clinical Case.

Endocrine, metabolic &amp; immune disorders drug targets
2025

Surgical Outcomes and Complications of Patients With Acromegaly in Qatar.

Cureus
2025

Diagnostic Delay in Acromegaly Due to Overlapping Features With Polycystic Ovary Syndrome: A Case Report.

Cureus
2026

Growth Hormone Assay-Adjusted Standardization Reveals Distinct Clinical Phenotypes in Acromegaly.

Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
2025

Exercise ventilatory inefficiency may be a specific feature of patients with acromegaly.

Pituitary
2025

Endocrinology and the Lung: Exploring the Bidirectional Axis and Future Directions.

Journal of clinical medicine
2025

Effects of Hormones on Left Heart Structure and Function with Echocardiography in Acromegaly.

Reviews in cardiovascular medicine
2025

SAGIT®, ACRODAT®, PANOMEN 3… time to implement tools for management of acromegaly..?

Pituitary
2025

Impact of GH and IGF-I excess on nervous and vascular retinal structure in newly diagnosed acromegaly patients.

Pituitary
2025

GIPR in GH-PitNETs: molecular and functional insights.

Endocrine-related cancer
2025

A Case of Acromegaly With Parasellar Meningioma With Oculomotor Palsy Responding to and Maintained With Oral Octreotide Therapy.

AACE endocrinology and diabetes
2025

Growth hormone excess drives liver aging via increased glycation stress.

Aging
2025

Possibility of calcification of type I collagen matrix in growth hormone-secreting pituitary neuroendocrine tumor.

Surgical neurology international
2025

Basilar artery vasospasm following transsphenoidal resection of recurrent pituitary macroadenoma: illustrative case.

Journal of neurosurgery. Case lessons
2026

Potential role of insulin-like growth factor 1 and growth hormone in acneiform eruptions: evidence from a rat model of acromegaly.

Journal of endocrinological investigation
2025

Personalized medicine in acromegaly: insights from the ACROFAST clinical trial.

Expert review of endocrinology &amp; metabolism
2025

[Spontaneous remission of neuroendocrine diseases due to apoplexy in hormonally active pituitary adenomas].

Problemy endokrinologii
2025

Insulin-like growth factor-I and symptoms of acromegaly according to time since somatostatin receptor ligand injection.

European journal of endocrinology
2025

The Evaluation of Retinal, Choroidal, Scleral, and Optic Disc Parameters in Acromegaly.

Ophthalmic surgery, lasers &amp; imaging retina
2025

Thoracic ultrasonography and pulmonary function tests in assessing lung function in acromegaly: a prospective matched case-control study.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace
2025

The Resolution of Photophobia and Short-Lasting Unilateral Neuralgiform Headache Attacks with Conjunctival Injection and Tearing (SUNCT) Subsequent to Growth Hormone Adenoma Resection: Elucidating the Proposed Pathophysiological Mechanisms.

Neuro-ophthalmology (Aeolus Press)
2025

Long-term antitumour effects of pasireotide in acromegaly.

European journal of endocrinology
2025

Idiopathic central sleep apnea: the past, the present, and the future.

Sleep
2025

Outcome of acromegalic patients undergoing endoscopic endonasal surgery: collaborative French and Italian cohort, a 25-year experience.

Neurosurgical review
2025

Metabolic Factors Related to Interpersonal Dysfunction in Acromegaly: A Nationwide Cross-Sectional Study in China.

CNS neuroscience &amp; therapeutics
2025

Revisiting mortality in acromegaly using machine learning.

Endocrine
2025

From Subtle Signs to Severe Sequelae-A Century of Symptomatology and Comorbidities in the Diagnosis of GH-Secreting Pituitary Neuroendocrine Tumors: A Systematic Review.

Diagnostics (Basel, Switzerland)
2026

Development of lateral flow assay for quantitative analysis of growth hormone.

Talanta
2025

Silent growth hormone pituitary adenomas: a single-center study.

Pituitary
2025

Time restricted eating and exercise training before and during pregnancy for people with increased risk of gestational diabetes: single centre randomised controlled trial (BEFORE THE BEGINNING).

BMJ (Clinical research ed.)
2025

Disease-Specific Mortality in Patients With Acromegaly Treated With Pegvisomant: An ACROSTUDY Analysis.

Endocrine connections
2025

NICTH with secondary acromegaloid changes and severe hypoglycemia due to potentially insulin-like growth factor-2 mediated effects.

Journal of diabetes and metabolic disorders
2025

The clinicopathological PANOMEN-3 classification predicts pituitary adenoma prognosis: a real-world retrospective single center study of a surgically treated cohort.

Pituitary
2025

Ecchordosis Physaliphora: A Rare and Challenging Clinical Entity in a Patient With Acromegaly.

JCEM case reports
2025

Comparison of triglyceride-glucose index and HOMA-IR in assessing insulin resistance in acromegaly: a case-control study.

Endokrynologia Polska
2025

Sclerostin levels in patients with acromegaly.

Endokrynologia Polska
2025

Supramolecular Microspheres Fabricated from Macrocycle-Incorporated Polymers and Their Biomedical Applications Based on Host-Guest Recognition.

Small methods
2025

Adherence, duration and healthcare costs in a real-world population of patients with acromegaly.

Journal of comparative effectiveness research
Ver todos os 6.824 no EuropePMC

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Associação brasileira dedicada a Mucopolissacaridoses.

Associação brasileira dedicada a Acromegalia.

Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Acromegalia

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Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Neuropsychological profile in acromegaly: a single center cross sectional analysis and preliminary prospective long-term study.
    Frontiers in neurology· 2026· PMID 41853178mais citado
  2. Case Report: Treatment of hypersomatotropism in a diabetic dog with transsphenoidal hypophysectomy.
    Frontiers in veterinary science· 2026· PMID 41822230mais citado
  3. Acromegaly presenting with normal insulin-like growth factor-1 levels in a patient with advanced liver cirrhosis.
    BMJ case reports· 2026· PMID 41713883mais citado
  4. Serum Lipidomic Profile Signature of Active Acromegaly and Relationships to Cardiovascular Disease.
    International journal of molecular sciences· 2026· PMID 41596725mais citado
  5. Altered Brain Function and Network Topology in Patients With Acromegaly: Resting-State fMRI Study of Networks Related to Cognitive and Emotional Processing.
    CNS neuroscience &amp; therapeutics· 2026· PMID 41550023mais citado
  6. The Many Faces of Acromegaly: Understanding Its Clinical and Biological Heterogeneity.
    Neuroendocrinology· 2026· PMID 41989974recente
  7. Disease-related burden and treatment experience in patients with acromegaly: a gender perspective.
    J Endocrinol Invest· 2026· PMID 41984405recente
  8. Long-term safety and efficacy of pegvisomant monotherapy for acromegaly: final data from the full ACROSTUDY cohort.
    Pituitary· 2026· PMID 41984268recente
  9. Current Controversies in Acromegaly Care.
    J Clin Endocrinol Metab· 2026· PMID 41981973recente
  10. Acromegaly in an Elderly Woman.
    Acta Med Indones· 2026· PMID 41978306recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:963(Orphanet)
  2. MONDO:0019933(MONDO)
  3. Acromegalia(PCDT · Ministério da Saúde)
  4. GARD:5725(GARD (NIH))
  5. Variantes catalogadas(ClinVar)
  6. Busca completa no PubMed(PubMed)
  7. Artigo Wikipedia(Wikipedia)
  8. Q189580(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Acromegalia
Compêndio · Raras BR

Acromegalia

ORPHA:963 · MONDO:0019933
🇧🇷 Brasil SUS
CEAF
1AOctreotida LAR1BLanreotidaCabergolinaPegvisomanto
Geral
Prevalência
1-9 / 100 000
Herança
Not applicable
CID-10
E22.0 · Acromegalia e gigantismo hipofisário
CID-11
Ensaios
17 ativos
Início
Adolescent, Adult, Childhood, Elderly, Infancy
Prevalência
3.6 (Spain)
MedGen
UMLS
C0001206
Repurposing
3 candidatos
bromocriptinedopamine receptor agonist
octreotidesomatostatin receptor agonist
pasireotide
EuropePMC
Wikidata
Wikipedia
Papers 10a
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