A paraparesia espástica tropical é uma mieloneuropatia inflamatória imunomediada sistêmica crônica, mais frequentemente relatada em mulheres do que em homens, que geralmente se apresenta na idade adulta com paraparesia espástica lentamente progressiva dos membros inferiores, disfunção da bexiga e do intestino e distúrbios sensoriais nas extremidades inferiores (por exemplo, parestesia e disestesia) e que está associada a uma infecção pelo vírus linfotrópico de células T humanas tipo 1 (HTLV-1).
Introdução
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A paraparesia espástica tropical é uma mieloneuropatia inflamatória imunomediada sistêmica crônica, mais frequentemente relatada em mulheres do que em homens, que geralmente se apresenta na idade adulta com paraparesia espástica lentamente progressiva dos membros inferiores, disfunção da bexiga e do intestino e distúrbios sensoriais nas extremidades inferiores (por exemplo, parestesia e disestesia) e que está associada a uma infecção pelo vírus linfotrópico de células T humanas tipo 1 (HTLV-1).
Escala de raridade
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1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Publicações mais relevantes
Self-management of HTLV-1-associated myelopathy/tropical spastic paraparesis in Japan: A qualitative study.
HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a spastic spinal cord-related paralysis that is caused by a human T-lymphotropic virus type 1 infection. Common symptoms of HAM/TSP include gait disorder, bladder disturbance, constipation, and sensory symptoms. Because no curative treatment exists, individuals with HAM/TSP have to self-manage their chronic condition. Although patients with HAM/TSP have unique self-management strategies owing to their complex backgrounds, limited information is available on how they self-manage their chronic conditions. This study aimed to explore the self-management strategies of patients with HAM/TSP in Japan. Using semi-structured interviews and an open-ended questionnaire, data were collected from seven participants with HAM/TSP. Interviews were transcribed verbatim. Data analysis was conducted using a qualitative content analysis method to identify categories that describe the self-management strategies of people with HAM/TSP. Six core categories of self-management strategies of people with HAM/TSP were identified: "Attempting to maintain body functions", "Acquiring new ways to complement body functions", "Engaging to maintain an independent daily life", "Ensuring a specialized treatment environment for HAM/TSP", "Taking control of HAM/TSP", and "Moving forward as people with HAM/TSP.". The self-management strategies of people with HAM/TSP are affected by three characteristics of HAM/TSP: the lack of an established curative treatment, the low social awareness of the disease, and its infectious nature. This study highlights the need for personalized educational strategies and accessible support for the development of self-management skills.
Urine Metabolomics and Machine Learning Identify Metabolic Features and Potential Biomarkers of HTLV-1-Associated Myelopathy (HAM).
Human T-cell lymphotropic virus type 1 (HTLV-1) can cause HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive neuroinflammatory disease that lacks noninvasive biomarkers. We used untargeted urine metabolomics with machine learning to profile 113 participants (39 with HAM, 17 with intermediate syndrome, 33 asymptomatic carriers, and 24 healthy controls). Gas chromatography-mass spectrometry identified 175 metabolites, 86 of which showed significant differences (fold change > 2, FDR p < 0.05). Multivariate analyses revealed distinct but partially overlapping metabolic profiles: sPLS-DA captured a reproducible yet moderately discriminative signal, while nonlinear machine learning models (Random Forest and SVM) achieved robust group separation, with HAM displaying a distinct metabolic signature. Key discriminators included Unknown_151, Unknown_127, histidine, alanine, and 4-hydroxyphenylacetic acid, which showed marked reductions in HAM and yielded ROC AUCs of 0.855-0.871. Pathway and disease enrichment analyses highlighted disturbances in amino acid metabolism, particularly beta-alanine and aromatic amino acids, along with disease signatures related to inherited amino acid handling disorders such as hyperlysinemia. These results demonstrate that urinary metabolomics combined with machine learning can identify potential noninvasive biomarkers for HAM and provide novel insights into HTLV-1-associated pathophysiology.
Assessment of Awareness and Knowledge Regarding Human T-Lymphotropic Virus Type 1 (HTLV-1) Among Healthcare Workers at Imam Khomeini Hospital Complex, Tehran, in 2023-2024, A Cross-Sectional Descriptive-Analytical Study.
Human T-Lymphotropic Virus Type 1 (HTLV-1), is responsible for serious diseases such as Adult T-cell leukemia/lymphoma (ATLL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). This research aimed to explore the level of awareness and knowledge of HTLV-1 among healthcare professionals working at Imam Khomeini hospital complex in Tehran to compare their knowledge in different aspects of this virus including basic knowledge, transmission, pathogenesis, prevention and treatment. This cross-sectional, descriptive-analytical study was conducted among healthcare personnel at Imam Khomeini Hospital Complex, Tehran, during 2023-2024. Data were collected using a validated questionnaire designed to assess knowledge and attitudes about HTLV-1. The questionnaire underwent expert review for validity and reliability testing, including a 2-week test-retest process with Cohen's kappa coefficient calculation. It included demographic data, binary knowledge questions about HTLV-1 transmission, symptoms, complications, prevention, and treatment. A total of 220 healthcare workers and students (63.6% female, 36.4% male) from medical, paramedical, and service fields participated in the study. Participants' attitude and knowledge levels were assessed using correct response rates, revealing significantly higher attitude scores (64.81%) compared to knowledge scores (42.61%) based on the Wilcoxon test (p < 0.05). Gender-based comparisons showed no statistically significant differences in attitudes (p = 0.30) or knowledge (p = 0.95). Age-group analyses using Kruskal-Wallis tests identified significant differences in knowledge performance (p = 0.00015), with the 26-35 age group outperforming others. Job position comparisons showed no significant differences in attitude or knowledge scores (p > 0.05). The study highlights a notable gap in knowledge about HTLV-1 among healthcare professionals at Imam Khomeini Hospital Complex, despite relatively positive attitudes. Significant differences in knowledge were observed across age groups, with the 26-35 age group demonstrating better awareness. These findings underscore the need for targeted educational programs to improve HTLV-1 knowledge, particularly among younger and less experienced staff, to enhance preventive and diagnostic capabilities.
Epidemiology of adult T-cell leukemia/lymphoma (ATL) in people living with HTLV-1: A 30-year study in Peru.
Adult T-cell Leukemia/Lymphoma (ATL) is caused by human T-leukemia virus type 1 (HTLV-1). Over 10 million people are infected worldwide, but only up to 5% develop ATL. HTLV-1 infection is endemic in Peru; however, there are currently no reports focusing on the epidemiological characteristics of Peruvian individuals with ATL. Data from the HTLV-1 Unit registry covering the period from June 1992 to November 2023 were retrospectively analyzed. Clinical report forms and histopathology records from national referral cancer centers were reviewed. Descriptive statistics were used to characterize patients, and Kaplan-Meier methods assessed survival by ATL subtype. A total of 116 confirmed ATL cases were identified. There was a slight female predominance, with 52.6% women (n = 61) and 47.4% men (n = 55). The median age at diagnosis was 54 years (IQR 42-61), with 42.2% of patients diagnosed before age 50. Only 13.8% of patients (n = 16) were diagnosed with HTLV-1 infection before ATL development, and only 8 of those were diagnosed through routine screening. The most common ATL subtype was lymphomatous (65.5%), followed by smoldering/chronic (24.1%), and acute ATL (9.5%). With a median follow-up of 15.9 months, median survival times were 6.5, 12.5, and 89.6 months for acute, lymphomatous, and smoldering/chronic subtypes, respectively. One-year survival rates ranged from 37.5% in acute ATL to 84.6% in smoldering/chronic ATL. Comorbid HTLV-1-associated diseases included infective dermatitis (15.5%), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) (8.6%), and Strongyloides stercoralis hyperinfection (6.9%). This is the first study to describe ATL epidemiology in Peru from an infectious disease perspective. Most patients were unaware of their HTLV-1 status before developing ATL, highlighting missed opportunities for earlier detection. Routine HTLV-1 testing should be considered in the evaluation of T-cell malignancies in endemic countries. In addition, screening high-risk populations could support earlier diagnosis and reduce transmission. Improving access to diagnostic tools, along with stronger collaboration between infectious diseases and oncology services could improve patient outcomes in endemic regions.
Dimethyl fumarate as a promising therapeutic candidate for virus-associated myelopathy.
Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neuroinflammatory disease with no effective treatment. In this study, we investigated whether dimethyl fumarate (DMF), an immunomodulatory agent approved for treating multiple sclerosis, exerts therapeutic effects relevant to HAM/TSP. Peripheral blood mononuclear cells (PBMCs) from 16 people living with HAM/TSP were used to evaluate the effects of DMF on cell viability, spontaneous proliferation, inflammatory cytokine production and HTLV-1 proviral load (PVL). DMF significantly inhibited lymphocyte proliferation in a concentration-dependent manner, with reductions of 42.1% at 10 µM, 56.3% at 25 µM, 60.6% at 50 µM and 69.9% at 100 µM. This suppressive effect was particularly evident in CD8+ T cells, CD4+ T cells and HTLV-1-infected CD4+ T cells. Furthermore, DMF reduced the production of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) released from these proliferating cells. A reduction in PVL was also observed in a subset of ex vivo PBMC cultures derived from individuals with HAM/TSP exhibiting high viral proliferative activity. These results suggest that DMF suppresses pathogenic immune activation in HAM/TSP and may therefore represent a promising therapeutic candidate for this disabling neuroinflammatory disorder.
Publicações recentes
HTLV1-associated myelopathy as a translational model of progressive neurodegeneration.
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🥉 Relato de casoSelf-management of HTLV-1-associated myelopathy/tropical spastic paraparesis in Japan: A qualitative study.
Acanthamoeba myelopathy mimicking tropical spastic paraparesis in immunocompetent hosts: a case series.
Urine Metabolomics and Machine Learning Identify Metabolic Features and Potential Biomarkers of HTLV-1-Associated Myelopathy (HAM).
📚 EuropePMC578 artigos no totalmostrando 196
Self-management of HTLV-1-associated myelopathy/tropical spastic paraparesis in Japan: A qualitative study.
PLoS neglected tropical diseasesAcanthamoeba myelopathy mimicking tropical spastic paraparesis in immunocompetent hosts: a case series.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyUrine Metabolomics and Machine Learning Identify Metabolic Features and Potential Biomarkers of HTLV-1-Associated Myelopathy (HAM).
International journal of molecular sciencesAssessment of Awareness and Knowledge Regarding Human T-Lymphotropic Virus Type 1 (HTLV-1) Among Healthcare Workers at Imam Khomeini Hospital Complex, Tehran, in 2023-2024, A Cross-Sectional Descriptive-Analytical Study.
Health science reportsEpidemiology and Clinical Outcomes of HTLV-1: A Comprehensive Narrative Review of Endemic and Nonendemic Regions.
The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicaleEpidemiology of adult T-cell leukemia/lymphoma (ATL) in people living with HTLV-1: A 30-year study in Peru.
PLoS neglected tropical diseasesMorbidity and Mortality Among People Living With HTLV-1: A 30-Year Retrospective Analysis in a Brazilian Cohort.
Journal of medical virologyUnmasking HAM/TSP: understanding HTLV-1-driven neurological disease.
Journal of neurovirologyEvaluation of the Association of Cytokines, Interleukin 6 Polymorphism, and Proviral Load With Myelopathy, Pain, and Functionality in HTLV1-Infected Patients.
Journal of medical virologySafety and efficacy of botulinum toxin in Human T-Lymphotropic Virus-1-Associated Myelopathy/Tropical Spastic Paraparesis: A randomized clinical trial.
The journal of spinal cord medicineEvidence of Spinal Cord Damage in Human T Cell Lymphotropic Virus Type 1-Infected Subjects Without Motor Disability.
The American journal of tropical medicine and hygieneDimethyl fumarate as a promising therapeutic candidate for virus-associated myelopathy.
Brain : a journal of neurologyTranscriptomic and Epitranscriptomic Landscape of Integrated HTLV-1 in MT2 Cells.
VirusesGlobal epidemiology of HTLV: Under-reported and under-studied regions.
Northern clinics of IstanbulExpanding the neurological spectrum of HTLV-1 beyond HAM/TSP: a contemporary perspective.
Lancet regional health. AmericasGut Microbiome Dysbiosis is Associated With Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection and Disease Progression to HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Cross-Sectional Study.
Smart medicineHigh-resolution analysis of the human T-cell leukemia virus capsid protein reveals insights into immature particle morphology.
Nature communicationsDeciphering HTLV-1-associated Lung Pathology through Integrated in vitro and Multi-cohort Multi-omics Analysis: Inflammation, Monocyte Recruitment and Differentiation Triggered by HTLV-1-exposed Alveolar Epithelial Cells.
Research squareHnRNPA1 and HuR, but not PTB, modulate cap-independent translation initiation from sense and antisense human T-cell lymphotropic virus type 1 mRNAs.
The FEBS journalIgG Idiotype Diversity Shapes Cytokine Profiles and Autoantibody Targets in HTLV-1 Clinical Outcomes.
International journal of molecular sciencesDevelopment of a LAMP-based diagnostic method for HTLV-1 using Iranian clinical samples.
Journal of virological methodsHTLV-1 Secreted Proteins Induce Axonal Degeneration Through Kinase and Phosphatase Activity Dysregulation.
AIDS research and human retrovirusesNeutralizing antibodies and the pathogenesis of HTLV-1: Insights from clinical cohorts.
Microbial pathogenesisCerebrospinal Fluid From Patients With HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) With Rapid Evolution Affects Mitochondrial DNA Transcription and Network Organization in Human Glioblastoma Cells.
Journal of medical virologyBCL-2 family dysregulation in HTLV-1 and BLV pathogenesis and its implications for leukemogenesis and therapy.
Molecular biology reportsHTLV-1-Specific CTL Accumulation in CSF Contributes to Neuroinflammation in HTLV-1-Associated Myelopathy.
Neurology(R) neuroimmunology & neuroinflammationTAX gene expression is associated with western blot patterns and high viral loadin HTLV-1 infected individuals.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]HTLV-1 and ATLL: Epidemiology, Oncogenesis, and Opportunities for Community-Informed Research in the United States.
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Current issues in molecular biologyA Simple, Highly Sensitive, and Highly Specific Dot-Blot-Based Immunoassay for Serodiagnosis of HTLV-1 in Resource-Limited Settings.
Tropical medicine and infectious diseaseRegulatory T cell plasticity and immune deviation toward autoinflammation in HTLV-1-associated diseases: insights and implications.
Expert review of clinical immunologySustained inflammation during human T-lymphotropic virus type 1 infection: a wildfire contributing to disease progression.
Frontiers in medicineAn HTLV-1-Infected Humanized Mouse Model Expressing HLA-A*02:01 Demonstrates Effective CTL-Mediated Suppression of HTLV-1.
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Frontiers in cellular and infection microbiologyCoincidental Coexistence of Human T-lymphotropic Virus Type 1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis and Myasthenia Gravis in a Patient With Chronic HTLV-1 Infection: A Case Report.
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Annals of clinical and translational neurologyPrevalence and Risk Factors Associated with Keratoconjunctivitis Sicca in People Living with Human T-Leukemia Virus Type 1: A Systematic Review and Meta-Analysis.
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JCI insightHTLV-1 p13 Protein Hijacks Macrophage Polarization and Promotes T-Cell Recruitment.
VirusesPhylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1-Associated HAM/TSP in Comparison with Asymptomatic Careers.
Iranian journal of public healthSilent dissemination of HTLV-1: evidence of intrafamilial transmission in a Brazilian reference centre.
Memorias do Instituto Oswaldo CruzHTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway.
bioRxiv : the preprint server for biologyDevelopment and optimization of human T-cell leukemia virus-specific antibody-dependent cell-mediated cytotoxicity (ADCC) assay directed to the envelope protein.
Journal of virologyDysregulation of the tumor suppressor Menin and its target Bach2 in HTLV-1 infection.
RetrovirologyPossible Trace of HTLV-1 Virus in Modulation of Cbl-b, ITCH, and PP2A Suppressor Genes.
International journal of molecular and cellular medicineHTLV-1-infected cells drive the differentiation of monocytes into macrophages in vitro.
BMC immunologyFirst Characterization of HTLV-1 Complete Genomes from Asymptomatic and Symptomatic Argentinean Patients.
AIDS research and human retrovirusesTrends of changes in human T-cell leukemia virus type 1 epidemiology in Japan and globally.
Leukemia researchYTHDF1 and YTHDC1 m6A reader proteins regulate HTLV-1 tax and hbz activity.
Journal of virologyIncidence of HTLV-1-associated myelopathy in the UK from 1991 to 2024: a longitudinal observational cohort study.
Frontiers in medicineDeclining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014-2021.
RetrovirologyEffects of probiotics on clinical manifestations and inflammatory markers in HTLV-1-associated myelopathy/tropical spastic paraparesis: A triple blind randomized, placebo controlled trial.
CytokineAcute Respiratory Failure Due to Mucous Plug in a Patient With Tropical Spastic Paraparesis.
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VirusesRadiological Changes in the Spinal Cord and Brain of Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).
Pathogens (Basel, Switzerland)Correlation Between TWEAK Serum Level and HTLV-1 Proviral Load in HAM/TSP.
Viral immunologyUrodynamic findings and vibegron effects on neurogenic lower urinary tract dysfunction caused by human T-cell leukemia virus type I-associated myelopathy/tropical spastic paraparesis.
IJU case reportsDiagnostic Value of Anti-HTLV-1-Antibody Quantification in Cerebrospinal Fluid for HTLV-1-Associated Myelopathy.
VirusesCognitive Assessment in HTLV-1 Patients Followed Up at a Reference Center in Salvador, Brazil.
VirusesDendritic Cells Pulsed with HAM/TSP Exosomes Sensitize CD4 T Cells to Enhance HTLV-1 Infection, Induce Helper T-Cell Polarization, and Decrease Cytotoxic T-Cell Response.
VirusesProgression of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis after Pregnancy: A Case Series and Review of the Literature.
Pathogens (Basel, Switzerland)Novel approaches for HTLV-1 therapy: innovative applications of CRISPR-Cas9.
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Vaccine: XRole of Interleukin-17 cytokine family in human T-cell lymphotropic virus type 1 (HTLV-1) infection and associated diseases.
CytokineEpidemiological and clinical profile of HTLV-1 patients: a closer look at a reference center in Bahia, Brazil.
VirusdiseaseHLA-A*24 Increases the Risk of HTLV-1-Associated Myelopathy despite Reducing HTLV-1 Proviral Load.
International journal of molecular sciencesImbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/ tropical spastic paraparesis.
BMC infectious diseasesNovel insights into human T-lymphotropic virus type-1 (HTLV-1) pathogenesis-host interactions in the manifestation of HTLV-1-associated myelopathy/tropical spastic paraparesis.
Reviews in medical virologyThe tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein.
Nature communicationsBlood-borne viruses and neurological manifestations: An overview.
Reviews in medical virologyHigher expression of BRCA1, and CHUK and lower expression of NFKBIA, ESR1, PIK3R1, and PPARG in HAM/TSP compared to ATLL, a diverse pathological consequence.
Indian journal of pathology & microbiologyLived Experience of Human T-cell Leukemia Virus type-1 -Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP): A Phenomenology Study.
Iranian journal of medical sciencesHuman T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation.
Infectious agents and cancerCannabinoid receptors as new targets for HTLV-1 associated myelopathy (HAM/TSP) treatment.
Multiple sclerosis and related disordersInfective dermatitis associated with human T-cell lymphotropic virus type-1, an underdiagnosed disease.
International journal of infectious diseases : IJID : official publication of the International Society for Infectious DiseasesAssessment of chronic pain and its association with functional capacity in patients with HTLV-1.
Pain medicine (Malden, Mass.)Complete Rescue of HTLV-1p12KO Infectivity by Depletion of Monocytes Together with NK and CD8+ T Cells.
Pathogens (Basel, Switzerland)Neurological aspects of HTLV-1 infection: symptoms in apparently asymptomatic carriers.
Journal of neurovirologyHTLV-1 Proviral Load Absolute RT-qPCR Development for Assessing on Clinical Outcomes in HAM/TSP Patients.
Reports of biochemistry & molecular biologyNon-cancerous complications in HTLV-1 carriers.
Expert review of anti-infective therapyHTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): Case based discussion of risk factors, clinical, and therapeutic considerations.
Journal of the neurological sciencesNonpharmacological interventions and outcomes in the management of complications of human T-cell lymphotropic virus type 1-related myelopathy/tropical spastic paraparesis: A systematic review.
Journal of research in medical sciences : the official journal of Isfahan University of Medical SciencesComprehensive Insight into the Functional Roles of NK and NKT Cells in HTLV-1-Associated Diseases and Asymptomatic Carriers.
Molecular neurobiologyMulticenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with human T-cell leukemia virus type-1-associated myelopathy.
Journal of neurologyAssociation between Brain White Matter Lesions and Disease Activity in HAM/TSP Patients.
Neurology internationalMycophenolate mofetil for the long-term treatment of HTLV-1 associated myelopathy: A case report.
Journal of neuroimmunologyDetermination of molecular epidemiologic pattern of human T-lymphotropic virus type 1 (HTLV-1) in Alborz province, Iran.
Virus genesHTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors.
Virology journalAn HTLV-1 envelope mRNA vaccine is immunogenic and protective in New Zealand rabbits.
Journal of virologyHTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1-associated myelopathy.
JCI insightA Textbook Case of Human T-lymphotropic Virus-1 (HTLV-1)-Induced Adult T-cell Leukemia Treated With Cyclophosphamide, Hydroxydaunorubicin, Oncovin, and Prednisone/Prednisolone (CHOP).
CureusAnti-HTLV-1 immunity combined with proviral load as predictive biomarkers for adult T-cell leukemia-lymphoma.
Cancer scienceAdvances in the treatment of human T-cell lymphotropic virus type-I associated myelopathy.
Expert review of neurotherapeuticsNatural Selection Signatures in the Hondo and Ryukyu Japanese Subpopulations.
Molecular biology and evolutionDecoding dysregulated angiogenesis in HTLV-1 asymptomatic carriers compared to healthy individuals.
Medical oncology (Northwood, London, England)Physiotherapy Methods Applied in the Prevention of Functional Loss Associated with Human T-Lymphotropic Virus 1 Infection: An Overview.
Infectious disease reportsDifferential modulation of IL-4, IL-10, IL-17, and IFN-γ production mediated by IgG from Human T-lymphotropic virus-1 (HTLV-1) infected patients on healthy peripheral T (CD4+, CD8+, and γδ) and B cells.
Frontiers in medicineT helper type 9 cell response and its role in the neurological clinic of patients with Human T-lymphotropic virus 1.
ImmunobiologyHTLV-1 p12 modulates the levels of prion protein (PrPC) in CD4+ T cells.
Frontiers in microbiologyViral Immune signatures from cerebrospinal fluid extracellular vesicles and particles in HAM and other chronic neurological diseases.
Frontiers in immunologyTropical spastic paraparesis.
Handbook of clinical neurologyPatient research priority setting partnership in human T-cell lymphotropic virus type I.
Health expectations : an international journal of public participation in health care and health policyRetroviral b-Zip protein (HBZ) contributes to the release of soluble and exosomal immune checkpoint molecules in the context of neuroinflammation.
Journal of extracellular biologyThe mirror like expression of genes involved in the FOXO signaling pathway could be effective in the pathogenesis of human lymphotropic virus type 1 (HTLV-1) through disruption of the downstream pathways.
BMC research notesInvestigating the effect of MAP2K1 gene (MEK1) in MAPK pathway in the induction of adult T-cell leukemia/lymphoma (ATLL).
Iranian journal of microbiologyPerformance of the National Institute of Infectious Diseases disability scale in HTLV-1-associated myelopathy/tropical spastic paraparesis.
Journal of neurovirologyCould Cesarean Delivery Help Prevent Mother-to-Child Transmission of Human T-Lymphotropic Virus Type 1?
The Journal of infectious diseasesHuman T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon.
Frontiers in cellular and infection microbiologyPentraxin 3, a serum biomarker in human T-cell lymphotropic virus type-1-associated myelopathy patients and asymptomatic carriers.
Medical microbiology and immunologyMechanisms of Innate Immune Sensing of HTLV-1 and Viral Immune Evasion.
Pathogens (Basel, Switzerland)HTLV-1 Proviral Load in Vaginal Fluid Correlates with Levels in Peripheral Blood Mononuclear Cells.
Pathogens (Basel, Switzerland)Cognitive deficits in HTLV-1 patients.
Journal of neurovirologyPutative role of HLA polymorphism among a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population.
Scientific reportsMogamulizumab for Treatment of Human T-lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Single-Center US-based Series.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaDetection of HTLV-1 proviral DNA in cell-free DNA: Potential for non-invasive monitoring of Adult T cell leukaemia/lymphoma using liquid biopsy?
Frontiers in immunologyIliopsoas Muscle Weakness as a Key Diagnostic Marker in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).
Pathogens (Basel, Switzerland)How Can We Prevent Mother-to-Child Transmission of HTLV-1?
International journal of molecular sciencesSigns and symptoms of human T-lymphotropic virus 1 and 2 infections in paediatric patients.
Tropical medicine & international health : TM & IHLong-term safety and efficacy of mogamulizumab (anti-CCR4) for treating virus-associated myelopathy.
Brain : a journal of neurologyVaginal dryness in women infected by human T-lymphotropic virus type 1: an exploratory study.
Sexual medicineImpaired flexibility in patients with tropical spastic paraparesis/HTLV-associated myelopathy: evaluation via pendulum fleximeter.
Arquivos de neuro-psiquiatriaIdentification and tracking of HTLV-1-infected T cell clones in virus-associated neurologic disease.
JCI insightApigenin improves cytotoxicity of antiretroviral drugs against HTLV-1 infected cells through the modulation of AhR signaling.
NeuroImmune pharmacology and therapeuticsSevere mitral regurgitation in chronic adult T-cell leukemia/lymphoma with granulomatous valvular inflammation.
Journal of cardiology casesHAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues.
Pathogens (Basel, Switzerland)Th17/IL-17 Axis in HTLV-1-Associated Myelopathy Tropical Spastic Paraparesis and Multiple Sclerosis: Novel Insights into the Immunity During HAMTSP.
Molecular neurobiologyPrecise excision of HTLV-1 provirus with a designer-recombinase.
Molecular therapy : the journal of the American Society of Gene TherapyHTLV-1-associated demyelinating neuropathy: A case report and review of the literature.
eNeurologicalSciInfection of the Ex Vivo Tonsil Model by HTLV-1 Envelope-Pseudotyped Viruses.
Pathogens (Basel, Switzerland)Geographic distribution, clinical epidemiology and genetic diversity of the human oncogenic retrovirus HTLV-1 in Africa, the world's largest endemic area.
Frontiers in immunologyCost-effectiveness of human T-cell leukemia virus type 1 (HTLV-1) antenatal screening for prevention of mother-to-child transmission.
PLoS neglected tropical diseasesHuman T-cell Leukemia Virus Type 1 (HTLV-1)-induced Uveitis.
Ocular immunology and inflammationSafety of intraocular anti-VEGF antibody treatment under in vitro HTLV-1 infection.
Frontiers in immunologyEvolution of erectile dysfunction in individuals infected with human T-lymphotropic virus 1: a prospective cohort study.
The journal of sexual medicinePathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL).
Critical reviews in clinical laboratory sciencesXCL1, a serum biomarker in neurological diseases; HTLV-1-associated myelopathy and multiple sclerosis.
Microbial pathogenesisSeroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature.
Clinical and experimental pediatricsEfficacy of l-Arginine treatment in patients with HTLV-1-associated neurological disease.
Annals of clinical and translational neurologyA newly identified interaction between nucleolar NPM1/B23 and the HTLV-I basic leucine zipper factor in HTLV-1 infected cells.
Frontiers in microbiologySystemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation.
Journal of neuroinflammationPostural Adjustments in HTLV-1 Infected Patients during a Self-Initiated Perturbation.
VirusesComparison of Static Balance Control in Infected Htlv-1 Subjects with Different Tsp/Ham Diagnosis.
VirusesParticularities of Neurological Manifestations in Adult T-Cell Leukemia/Lymphoma: Need for a Multidisciplinary Approach-A Narrative Review.
Medicina (Kaunas, Lithuania)Establishment of a Cynomolgus Macaque Model of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Direct Inoculation of Adult T-Cell Leukemia Patient-Derived Cell Lines for HTLV-1 Infection.
Journal of virologyTNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals.
Frontiers in immunologyDevelopment of a Monoclonal Antibody Targeting HTLV-1 Envelope gp46 Glycoprotein and Its Application to Near-Infrared Photoimmuno-Antimicrobial Strategy.
VirusesLessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development.
VirusesHijacking Host Immunity by the Human T-Cell Leukemia Virus Type-1: Implications for Therapeutic and Preventive Vaccines.
VirusesT cell receptor repertoire analysis in HTLV-1-associated diseases.
Frontiers in immunologyCo-Infection and Cancer: Host-Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic Viruses.
VirusesMiR-150 in HTLV-1 infection and T-cell transformation.
Frontiers in immunologyChitotriosidase 1 in the cerebrospinal fluid as a putative biomarker for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) progression.
Frontiers in immunologySelective APC-targeting of a novel Fc-fusion multi-immunodominant recombinant protein (tTax-tEnv:mFcγ2a) for HTLV-1 vaccine development.
Life sciencesPhenotypic and functional analysis of γδ T cells in the pathogenesis of human T-cell lymphotropic virus type 1 infection.
Frontiers in immunologyProbable HTLV-I/II Tropical Spastic Paraparesis Patient from Ethiopia: A Case Report.
Ethiopian journal of health sciencesWork ability and associated factors in people living with human T-cell leukemia virus type 1.
Revista da Sociedade Brasileira de Medicina TropicalIs the HTLV-1 Retrovirus Targeted by Host Restriction Factors?
VirusesEffect of HTLV-1 Infection on the Clinical Course of Patients with Rheumatoid Arthritis.
VirusesMaking Visible HTLV Infection in a Non-endemic Area of Argentina.
Frontiers in medicineAn Overview of Human T-Lymphotropic Virus Type 1 Lung Injury.
Frontiers in immunologyHuman T Lymphotropic Virus 1-Associated Myelopathy: Overview of Human T Cell Lymphotropic Virus-1/2 Tests and Potential Biomarkers.
AIDS research and human retrovirusesThe Road to HTLV-1-Induced Leukemia by Following the Subcellular Localization of HTLV-1-Encoded HBZ Protein.
Frontiers in immunologyRapid and Sensitive Qualitative Duoplex Real-Time PCR Method for Discriminatory and Confirmatory Diagnosis of HTLV-1 and HTLV-2 Infections: Brazilian Multicentric Study.
Frontiers in medicineIntegrative and Multidisciplinary Care for People Living With Human T-Cell Lymphotropic Virus in Bahia, Brazil: 20 Years of Experience.
Frontiers in medicineAssociation of the p75NTR Ser205Leu Polymorphism with Asymptomatic HTLV-1 Infection.
VirusesHTLV, a multi organ oncovirus.
Microbial pathogenesisFactors Involved in Pain Perception and Quality of Life in Patients with Tropical Spastic Paraparesis.
Revista da Sociedade Brasileira de Medicina TropicalIdentification of hub genes and molecular pathways in human T-lymphotropic virus type 1 associated diseases using protein-protein interactions networks.
Iranian journal of microbiologyThe Past, Present, and Future of a Human T-Cell Leukemia Virus Type 1 Vaccine.
Frontiers in microbiologyThe Expression of Tax and HBZ Genes in Serum-Derived Extracellular Vesicles From HTLV-1 Carriers Correlates to Proviral Load and Inflammatory Markers.
Frontiers in microbiologyHuman T-lymphotropic virus type 1 and novel coronavirus disease 2019; More complex than just a simple coinfection.
GeneCabotegravir, the Long-Acting Integrase Strand Transfer Inhibitor, Potently Inhibits Human T-Cell Lymphotropic Virus Type 1 Transmission in vitro.
Frontiers in medicineCurrent Perspectives in Human T-Cell Leukemia Virus Type 1 Infection and Its Associated Diseases.
Frontiers in medicineUpdates on HTLV-1 Uveitis.
VirusesEvaluation of antioxidant status and oxidative stress markers in HTLV-1 infected individuals: correlation with the severity of virus-induced complications.
Journal of medical microbiologyCardiovascular risk factors and brain white matter lesions in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).
Journal of neurovirologyClinical and Public Health Implications of Human T-Lymphotropic Virus Type 1 Infection.
Clinical microbiology reviewsRegulation of HTLV-1 transformation.
Bioscience reportsCognitive screening in HTLV-1-infected people using a self-perceived memory score and auditory P300.
Journal of neurovirologyFrequency and characteristics of HTLV in migrants: results from the +Redivi collaborative network in Spain.
Journal of travel medicineHIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread.
VirusesHuman T-Cell Leukemia Virus Type 1 Envelope Protein: Post-Entry Roles in Viral Pathogenesis.
VirusesIntegration of gene co-expression analysis and multi-class SVM specifies the functional players involved in determining the fate of HTLV-1 infection toward the development of cancer (ATLL) or neurological disorder (HAM/TSP).
PloS oneMonitoring of HTLV-1-associated diseases by proviral load quantification using multiplex real-time PCR.
Journal of neurovirologyNanomicellar Curcumin Supplementation Improves the Clinical Manifestations of HAM/TSP Patients.
Advances in experimental medicine and biologyCerebral and spinal cord changes observed through magnetic resonance imaging in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis: a systematic review.
Journal of neurovirologyAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Self-management of HTLV-1-associated myelopathy/tropical spastic paraparesis in Japan: A qualitative study.
- Urine Metabolomics and Machine Learning Identify Metabolic Features and Potential Biomarkers of HTLV-1-Associated Myelopathy (HAM).
- Assessment of Awareness and Knowledge Regarding Human T-Lymphotropic Virus Type 1 (HTLV-1) Among Healthcare Workers at Imam Khomeini Hospital Complex, Tehran, in 2023-2024, A Cross-Sectional Descriptive-Analytical Study.
- Epidemiology of adult T-cell leukemia/lymphoma (ATL) in people living with HTLV-1: A 30-year study in Peru.
- Dimethyl fumarate as a promising therapeutic candidate for virus-associated myelopathy.
- HTLV1-associated myelopathy as a translational model of progressive neurodegeneration.
- Interferon dynamics in deltaretroviruses: why HTLV-1 evades, but BLV responds.
- Acanthamoeba myelopathy mimicking tropical spastic paraparesis in immunocompetent hosts: a case series.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:289326(Orphanet)
- OMIM OMIM:159580(OMIM)
- MONDO:0008039(MONDO)
- GARD:8208(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q1476361(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
