Raras
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Paraparesia espástica tropical
ORPHA:289326CID-10 · G04.1CID-11 · 8A45.00OMIM 159580DOENÇA RARA

A paraparesia espástica tropical é uma mieloneuropatia inflamatória imunomediada sistêmica crônica, mais frequentemente relatada em mulheres do que em homens, que geralmente se apresenta na idade adulta com paraparesia espástica lentamente progressiva dos membros inferiores, disfunção da bexiga e do intestino e distúrbios sensoriais nas extremidades inferiores (por exemplo, parestesia e disestesia) e que está associada a uma infecção pelo vírus linfotrópico de células T humanas tipo 1 (HTLV-1).

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Introdução

O que você precisa saber de cara

📋

A paraparesia espástica tropical é uma mieloneuropatia inflamatória imunomediada sistêmica crônica, mais frequentemente relatada em mulheres do que em homens, que geralmente se apresenta na idade adulta com paraparesia espástica lentamente progressiva dos membros inferiores, disfunção da bexiga e do intestino e distúrbios sensoriais nas extremidades inferiores (por exemplo, parestesia e disestesia) e que está associada a uma infecção pelo vírus linfotrópico de células T humanas tipo 1 (HTLV-1).

Pesquisas ativas
1 ensaio
24 total registrados no ClinicalTrials.gov
Publicações científicas
1.834 artigos
Último publicado: 2026 Apr 2

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Início
Adult
🏥
SUS: Cobertura mínimaScore: 15%
CID-10: G04.1
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🧠
Neurológico
2 sintomas
💪
Músculos
2 sintomas

+ 1 sintomas em outras categorias

Características mais comuns

Mielopatia
Sinal piramidal anormal
Paraparesia espástica
Fraqueza muscular
Rigidez muscular
5sintomas
Sem dados (5)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 5 características clínicas mais associadas, ordenadas por frequência.

MielopatiaMyelopathy
Sinal piramidal anormalAbnormal pyramidal sign
Paraparesia espásticaSpastic paraparesis
Fraqueza muscularMuscle weakness
Rigidez muscularMuscle stiffness

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico1.834PubMed
Últimos 10 anos200publicações
Pico202250 papers
Linha do tempo
2026Hoje · 2026🧪 1976Primeiro ensaio clínico📈 2022Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 32
2Fase 21
1Fase 11
·Pré-clínico4
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 8 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Paraparesia espástica tropical

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

24 ensaios clínicos encontrados, 1 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

🥉Melhor nível de evidência: Relato de caso
Timeline de publicações
551 papers (10 anos)
#1

Self-management of HTLV-1-associated myelopathy/tropical spastic paraparesis in Japan: A qualitative study.

PLoS neglected tropical diseases2026 Mar 19

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a spastic spinal cord-related paralysis that is caused by a human T-lymphotropic virus type 1 infection. Common symptoms of HAM/TSP include gait disorder, bladder disturbance, constipation, and sensory symptoms. Because no curative treatment exists, individuals with HAM/TSP have to self-manage their chronic condition. Although patients with HAM/TSP have unique self-management strategies owing to their complex backgrounds, limited information is available on how they self-manage their chronic conditions. This study aimed to explore the self-management strategies of patients with HAM/TSP in Japan. Using semi-structured interviews and an open-ended questionnaire, data were collected from seven participants with HAM/TSP. Interviews were transcribed verbatim. Data analysis was conducted using a qualitative content analysis method to identify categories that describe the self-management strategies of people with HAM/TSP. Six core categories of self-management strategies of people with HAM/TSP were identified: "Attempting to maintain body functions", "Acquiring new ways to complement body functions", "Engaging to maintain an independent daily life", "Ensuring a specialized treatment environment for HAM/TSP", "Taking control of HAM/TSP", and "Moving forward as people with HAM/TSP.". The self-management strategies of people with HAM/TSP are affected by three characteristics of HAM/TSP: the lack of an established curative treatment, the low social awareness of the disease, and its infectious nature. This study highlights the need for personalized educational strategies and accessible support for the development of self-management skills.

#2

Urine Metabolomics and Machine Learning Identify Metabolic Features and Potential Biomarkers of HTLV-1-Associated Myelopathy (HAM).

International journal of molecular sciences2026 Feb 14

Human T-cell lymphotropic virus type 1 (HTLV-1) can cause HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP), a progressive neuroinflammatory disease that lacks noninvasive biomarkers. We used untargeted urine metabolomics with machine learning to profile 113 participants (39 with HAM, 17 with intermediate syndrome, 33 asymptomatic carriers, and 24 healthy controls). Gas chromatography-mass spectrometry identified 175 metabolites, 86 of which showed significant differences (fold change > 2, FDR p < 0.05). Multivariate analyses revealed distinct but partially overlapping metabolic profiles: sPLS-DA captured a reproducible yet moderately discriminative signal, while nonlinear machine learning models (Random Forest and SVM) achieved robust group separation, with HAM displaying a distinct metabolic signature. Key discriminators included Unknown_151, Unknown_127, histidine, alanine, and 4-hydroxyphenylacetic acid, which showed marked reductions in HAM and yielded ROC AUCs of 0.855-0.871. Pathway and disease enrichment analyses highlighted disturbances in amino acid metabolism, particularly beta-alanine and aromatic amino acids, along with disease signatures related to inherited amino acid handling disorders such as hyperlysinemia. These results demonstrate that urinary metabolomics combined with machine learning can identify potential noninvasive biomarkers for HAM and provide novel insights into HTLV-1-associated pathophysiology.

#3

Assessment of Awareness and Knowledge Regarding Human T-Lymphotropic Virus Type 1 (HTLV-1) Among Healthcare Workers at Imam Khomeini Hospital Complex, Tehran, in 2023-2024, A Cross-Sectional Descriptive-Analytical Study.

Health science reports2026 Feb

Human T-Lymphotropic Virus Type 1 (HTLV-1), is responsible for serious diseases such as Adult T-cell leukemia/lymphoma (ATLL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). This research aimed to explore the level of awareness and knowledge of HTLV-1 among healthcare professionals working at Imam Khomeini hospital complex in Tehran to compare their knowledge in different aspects of this virus including basic knowledge, transmission, pathogenesis, prevention and treatment. This cross-sectional, descriptive-analytical study was conducted among healthcare personnel at Imam Khomeini Hospital Complex, Tehran, during 2023-2024. Data were collected using a validated questionnaire designed to assess knowledge and attitudes about HTLV-1. The questionnaire underwent expert review for validity and reliability testing, including a 2-week test-retest process with Cohen's kappa coefficient calculation. It included demographic data, binary knowledge questions about HTLV-1 transmission, symptoms, complications, prevention, and treatment. A total of 220 healthcare workers and students (63.6% female, 36.4% male) from medical, paramedical, and service fields participated in the study. Participants' attitude and knowledge levels were assessed using correct response rates, revealing significantly higher attitude scores (64.81%) compared to knowledge scores (42.61%) based on the Wilcoxon test (p < 0.05). Gender-based comparisons showed no statistically significant differences in attitudes (p = 0.30) or knowledge (p = 0.95). Age-group analyses using Kruskal-Wallis tests identified significant differences in knowledge performance (p = 0.00015), with the 26-35 age group outperforming others. Job position comparisons showed no significant differences in attitude or knowledge scores (p > 0.05). The study highlights a notable gap in knowledge about HTLV-1 among healthcare professionals at Imam Khomeini Hospital Complex, despite relatively positive attitudes. Significant differences in knowledge were observed across age groups, with the 26-35 age group demonstrating better awareness. These findings underscore the need for targeted educational programs to improve HTLV-1 knowledge, particularly among younger and less experienced staff, to enhance preventive and diagnostic capabilities.

#4

Epidemiology of adult T-cell leukemia/lymphoma (ATL) in people living with HTLV-1: A 30-year study in Peru.

PLoS neglected tropical diseases2026 Feb

Adult T-cell Leukemia/Lymphoma (ATL) is caused by human T-leukemia virus type 1 (HTLV-1). Over 10 million people are infected worldwide, but only up to 5% develop ATL. HTLV-1 infection is endemic in Peru; however, there are currently no reports focusing on the epidemiological characteristics of Peruvian individuals with ATL. Data from the HTLV-1 Unit registry covering the period from June 1992 to November 2023 were retrospectively analyzed. Clinical report forms and histopathology records from national referral cancer centers were reviewed. Descriptive statistics were used to characterize patients, and Kaplan-Meier methods assessed survival by ATL subtype. A total of 116 confirmed ATL cases were identified. There was a slight female predominance, with 52.6% women (n = 61) and 47.4% men (n = 55). The median age at diagnosis was 54 years (IQR 42-61), with 42.2% of patients diagnosed before age 50. Only 13.8% of patients (n = 16) were diagnosed with HTLV-1 infection before ATL development, and only 8 of those were diagnosed through routine screening. The most common ATL subtype was lymphomatous (65.5%), followed by smoldering/chronic (24.1%), and acute ATL (9.5%). With a median follow-up of 15.9 months, median survival times were 6.5, 12.5, and 89.6 months for acute, lymphomatous, and smoldering/chronic subtypes, respectively. One-year survival rates ranged from 37.5% in acute ATL to 84.6% in smoldering/chronic ATL. Comorbid HTLV-1-associated diseases included infective dermatitis (15.5%), HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) (8.6%), and Strongyloides stercoralis hyperinfection (6.9%). This is the first study to describe ATL epidemiology in Peru from an infectious disease perspective. Most patients were unaware of their HTLV-1 status before developing ATL, highlighting missed opportunities for earlier detection. Routine HTLV-1 testing should be considered in the evaluation of T-cell malignancies in endemic countries. In addition, screening high-risk populations could support earlier diagnosis and reduce transmission. Improving access to diagnostic tools, along with stronger collaboration between infectious diseases and oncology services could improve patient outcomes in endemic regions.

#5

Dimethyl fumarate as a promising therapeutic candidate for virus-associated myelopathy.

Brain : a journal of neurology2026 Feb 05

Human T-cell lymphotropic virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive neuroinflammatory disease with no effective treatment. In this study, we investigated whether dimethyl fumarate (DMF), an immunomodulatory agent approved for treating multiple sclerosis, exerts therapeutic effects relevant to HAM/TSP. Peripheral blood mononuclear cells (PBMCs) from 16 people living with HAM/TSP were used to evaluate the effects of DMF on cell viability, spontaneous proliferation, inflammatory cytokine production and HTLV-1 proviral load (PVL). DMF significantly inhibited lymphocyte proliferation in a concentration-dependent manner, with reductions of 42.1% at 10 µM, 56.3% at 25 µM, 60.6% at 50 µM and 69.9% at 100 µM. This suppressive effect was particularly evident in CD8+ T cells, CD4+ T cells and HTLV-1-infected CD4+ T cells. Furthermore, DMF reduced the production of interleukin (IL)-6, tumor necrosis factor-alpha (TNF-α) and interferon-gamma (IFN-γ) released from these proliferating cells. A reduction in PVL was also observed in a subset of ex vivo PBMC cultures derived from individuals with HAM/TSP exhibiting high viral proliferative activity. These results suggest that DMF suppresses pathogenic immune activation in HAM/TSP and may therefore represent a promising therapeutic candidate for this disabling neuroinflammatory disorder.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC578 artigos no totalmostrando 196

2026

Self-management of HTLV-1-associated myelopathy/tropical spastic paraparesis in Japan: A qualitative study.

PLoS neglected tropical diseases
2026

Acanthamoeba myelopathy mimicking tropical spastic paraparesis in immunocompetent hosts: a case series.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2026

Urine Metabolomics and Machine Learning Identify Metabolic Features and Potential Biomarkers of HTLV-1-Associated Myelopathy (HAM).

International journal of molecular sciences
2026

Assessment of Awareness and Knowledge Regarding Human T-Lymphotropic Virus Type 1 (HTLV-1) Among Healthcare Workers at Imam Khomeini Hospital Complex, Tehran, in 2023-2024, A Cross-Sectional Descriptive-Analytical Study.

Health science reports
2026

Epidemiology and Clinical Outcomes of HTLV-1: A Comprehensive Narrative Review of Endemic and Nonendemic Regions.

The Canadian journal of infectious diseases &amp; medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale
2026

Epidemiology of adult T-cell leukemia/lymphoma (ATL) in people living with HTLV-1: A 30-year study in Peru.

PLoS neglected tropical diseases
2026

Morbidity and Mortality Among People Living With HTLV-1: A 30-Year Retrospective Analysis in a Brazilian Cohort.

Journal of medical virology
2026

Unmasking HAM/TSP: understanding HTLV-1-driven neurological disease.

Journal of neurovirology
2026

Evaluation of the Association of Cytokines, Interleukin 6 Polymorphism, and Proviral Load With Myelopathy, Pain, and Functionality in HTLV1-Infected Patients.

Journal of medical virology
2026

Safety and efficacy of botulinum toxin in Human T-Lymphotropic Virus-1-Associated Myelopathy/Tropical Spastic Paraparesis: A randomized clinical trial.

The journal of spinal cord medicine
2026

Evidence of Spinal Cord Damage in Human T Cell Lymphotropic Virus Type 1-Infected Subjects Without Motor Disability.

The American journal of tropical medicine and hygiene
2026

Dimethyl fumarate as a promising therapeutic candidate for virus-associated myelopathy.

Brain : a journal of neurology
2025

Transcriptomic and Epitranscriptomic Landscape of Integrated HTLV-1 in MT2 Cells.

Viruses
2025

Global epidemiology of HTLV: Under-reported and under-studied regions.

Northern clinics of Istanbul
2026

Expanding the neurological spectrum of HTLV-1 beyond HAM/TSP: a contemporary perspective.

Lancet regional health. Americas
2026

Gut Microbiome Dysbiosis is Associated With Human T-Lymphotropic Virus Type 1 (HTLV-1) Infection and Disease Progression to HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis: A Cross-Sectional Study.

Smart medicine
2025

High-resolution analysis of the human T-cell leukemia virus capsid protein reveals insights into immature particle morphology.

Nature communications
2025

Deciphering HTLV-1-associated Lung Pathology through Integrated in vitro and Multi-cohort Multi-omics Analysis: Inflammation, Monocyte Recruitment and Differentiation Triggered by HTLV-1-exposed Alveolar Epithelial Cells.

Research square
2025

HnRNPA1 and HuR, but not PTB, modulate cap-independent translation initiation from sense and antisense human T-cell lymphotropic virus type 1 mRNAs.

The FEBS journal
2025

IgG Idiotype Diversity Shapes Cytokine Profiles and Autoantibody Targets in HTLV-1 Clinical Outcomes.

International journal of molecular sciences
2026

Development of a LAMP-based diagnostic method for HTLV-1 using Iranian clinical samples.

Journal of virological methods
2025

HTLV-1 Secreted Proteins Induce Axonal Degeneration Through Kinase and Phosphatase Activity Dysregulation.

AIDS research and human retroviruses
2026

Neutralizing antibodies and the pathogenesis of HTLV-1: Insights from clinical cohorts.

Microbial pathogenesis
2025

Cerebrospinal Fluid From Patients With HTLV-1-associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP) With Rapid Evolution Affects Mitochondrial DNA Transcription and Network Organization in Human Glioblastoma Cells.

Journal of medical virology
2025

BCL-2 family dysregulation in HTLV-1 and BLV pathogenesis and its implications for leukemogenesis and therapy.

Molecular biology reports
2026

HTLV-1-Specific CTL Accumulation in CSF Contributes to Neuroinflammation in HTLV-1-Associated Myelopathy.

Neurology(R) neuroimmunology &amp; neuroinflammation
2025

TAX gene expression is associated with western blot patterns and high viral loadin HTLV-1 infected individuals.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
2025

HTLV-1 and ATLL: Epidemiology, Oncogenesis, and Opportunities for Community-Informed Research in the United States.

Viruses
2025

In Vitro Model of the Human Blood-Brain Barrier to Explore HTLV-1 Immunopathogenesis.

Current issues in molecular biology
2025

A Simple, Highly Sensitive, and Highly Specific Dot-Blot-Based Immunoassay for Serodiagnosis of HTLV-1 in Resource-Limited Settings.

Tropical medicine and infectious disease
2025

Regulatory T cell plasticity and immune deviation toward autoinflammation in HTLV-1-associated diseases: insights and implications.

Expert review of clinical immunology
2025

Sustained inflammation during human T-lymphotropic virus type 1 infection: a wildfire contributing to disease progression.

Frontiers in medicine
2025

An HTLV-1-Infected Humanized Mouse Model Expressing HLA-A*02:01 Demonstrates Effective CTL-Mediated Suppression of HTLV-1.

Viruses
2025

Human T-cell leukemia virus type 1: oncogenic potential and vaccine development strategies.

Frontiers in cellular and infection microbiology
2025

Coincidental Coexistence of Human T-lymphotropic Virus Type 1 (HTLV-1)-Associated Myelopathy/Tropical Spastic Paraparesis and Myasthenia Gravis in a Patient With Chronic HTLV-1 Infection: A Case Report.

Cureus
2025

Adverse Lipid Profiles and Increased Cardiovascular Risks in People with HAM/TSP.

AIDS research and human retroviruses
2025

Efgartigimod Combined With Steroid Treatment for HAM/TSP: A Case Report.

Annals of clinical and translational neurology
2025

Prevalence and Risk Factors Associated with Keratoconjunctivitis Sicca in People Living with Human T-Leukemia Virus Type 1: A Systematic Review and Meta-Analysis.

Ocular immunology and inflammation
2025

Untangling the causes of geographical disparities in the clinical outcome of HTLV-1 infection: a critical perspective on the contribution of viral genetic diversity.

Journal of virology
2025

Clinical Characteristics of Parkinsonism in HTLV-1-Associated Myelopathy.

Annals of clinical and translational neurology
2025

Astonish yourself while worrying about another: Patients' reactions of HTLV-1-associated myelopathy/tropical spastic paraparesis diagnosis.

Caspian journal of internal medicine
2025

Human T-Lymphotropic Virus (HTLV): Epidemiology, Genetic, Pathogenesis, and Future Challenges.

Viruses
2025

HTLV-1 infection and microRNAs: unraveling the complex crosstalk.

Infectious agents and cancer
2025

Clinical and molecular evidences of HTLV-1 infection in inpatients diagnosed with diseases previously described as associated to this infection: A case series in Gabon, Central Africa.

PLoS neglected tropical diseases
2025

Safety and efficacy of teriflunomide on clinical course, and laboratory findings in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis: a triple-blind study.

Journal of neurology
2025

Virus-induced RGMa expression drives neurodegeneration in HTLV-1-associated myelopathy.

JCI insight
2025

HTLV-1 p13 Protein Hijacks Macrophage Polarization and Promotes T-Cell Recruitment.

Viruses
2025

Phylogenetic and Mutational Analysis of the Tax Gene in the Human T-Lymphotropic Virus 1-Associated HAM/TSP in Comparison with Asymptomatic Careers.

Iranian journal of public health
2025

Silent dissemination of HTLV-1: evidence of intrafamilial transmission in a Brazilian reference centre.

Memorias do Instituto Oswaldo Cruz
2025

HTLV-1 Tax induces PINK1-Parkin-dependent mitophagy to mitigate activation of the cGAS-STING pathway.

bioRxiv : the preprint server for biology
2025

Development and optimization of human T-cell leukemia virus-specific antibody-dependent cell-mediated cytotoxicity (ADCC) assay directed to the envelope protein.

Journal of virology
2025

Dysregulation of the tumor suppressor Menin and its target Bach2 in HTLV-1 infection.

Retrovirology
2025

Possible Trace of HTLV-1 Virus in Modulation of Cbl-b, ITCH, and PP2A Suppressor Genes.

International journal of molecular and cellular medicine
2025

HTLV-1-infected cells drive the differentiation of monocytes into macrophages in vitro.

BMC immunology
2025

First Characterization of HTLV-1 Complete Genomes from Asymptomatic and Symptomatic Argentinean Patients.

AIDS research and human retroviruses
2025

Trends of changes in human T-cell leukemia virus type 1 epidemiology in Japan and globally.

Leukemia research
2025

YTHDF1 and YTHDC1 m6A reader proteins regulate HTLV-1 tax and hbz activity.

Journal of virology
2024

Incidence of HTLV-1-associated myelopathy in the UK from 1991 to 2024: a longitudinal observational cohort study.

Frontiers in medicine
2024

Declining trend of HTLV-1 among organ/ tissue donors in Iranian Tissue Bank between 2014-2021.

Retrovirology
2025

Effects of probiotics on clinical manifestations and inflammatory markers in HTLV-1-associated myelopathy/tropical spastic paraparesis: A triple blind randomized, placebo controlled trial.

Cytokine
2024

Acute Respiratory Failure Due to Mucous Plug in a Patient With Tropical Spastic Paraparesis.

Cureus
2024

New insight into the molecular etiopathogenesis of konzo: Cyanate could be a plausible neurotoxin contributing to konzo, contrary to thiocyanate.

Neurotoxicology
2024

Characterization of HTLV-1 Infectious Molecular Clone Isolated from Patient with HAM/TSP and Immortalization of Human Primary T-Cell Lines.

Viruses
2024

Radiological Changes in the Spinal Cord and Brain of Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).

Pathogens (Basel, Switzerland)
2024

Correlation Between TWEAK Serum Level and HTLV-1 Proviral Load in HAM/TSP.

Viral immunology
2024

Urodynamic findings and vibegron effects on neurogenic lower urinary tract dysfunction caused by human T-cell leukemia virus type I-associated myelopathy/tropical spastic paraparesis.

IJU case reports
2024

Diagnostic Value of Anti-HTLV-1-Antibody Quantification in Cerebrospinal Fluid for HTLV-1-Associated Myelopathy.

Viruses
2024

Cognitive Assessment in HTLV-1 Patients Followed Up at a Reference Center in Salvador, Brazil.

Viruses
2024

Dendritic Cells Pulsed with HAM/TSP Exosomes Sensitize CD4 T Cells to Enhance HTLV-1 Infection, Induce Helper T-Cell Polarization, and Decrease Cytotoxic T-Cell Response.

Viruses
2024

Progression of HTLV-1 Associated Myelopathy/Tropical Spastic Paraparesis after Pregnancy: A Case Series and Review of the Literature.

Pathogens (Basel, Switzerland)
2024

Novel approaches for HTLV-1 therapy: innovative applications of CRISPR-Cas9.

Revista do Instituto de Medicina Tropical de Sao Paulo
2024

Effects of HTLV-1 on leukocyte trafficking and migration in ACs compared to healthy individuals.

BMC research notes
2024

HTLV-1 vaccination Landscape: Current developments and challenges.

Vaccine: X
2024

Role of Interleukin-17 cytokine family in human T-cell lymphotropic virus type 1 (HTLV-1) infection and associated diseases.

Cytokine
2024

Epidemiological and clinical profile of HTLV-1 patients: a closer look at a reference center in Bahia, Brazil.

Virusdisease
2024

HLA-A*24 Increases the Risk of HTLV-1-Associated Myelopathy despite Reducing HTLV-1 Proviral Load.

International journal of molecular sciences
2024

Imbalanced IL10/TGF-β production by regulatory T-lymphocytes in patients with HTLV-1-associated myelopathy/ tropical spastic paraparesis.

BMC infectious diseases
2024

Novel insights into human T-lymphotropic virus type-1 (HTLV-1) pathogenesis-host interactions in the manifestation of HTLV-1-associated myelopathy/tropical spastic paraparesis.

Reviews in medical virology
2024

The tyrosine kinase KDR is essential for the survival of HTLV-1-infected T cells by stabilizing the Tax oncoprotein.

Nature communications
2024

Blood-borne viruses and neurological manifestations: An overview.

Reviews in medical virology
2024

Higher expression of BRCA1, and CHUK and lower expression of NFKBIA, ESR1, PIK3R1, and PPARG in HAM/TSP compared to ATLL, a diverse pathological consequence.

Indian journal of pathology &amp; microbiology
2024

Lived Experience of Human T-cell Leukemia Virus type-1 -Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP): A Phenomenology Study.

Iranian journal of medical sciences
2024

Human T-cell lymphotropic virus type 1 (HTLV-1) grip on T-cells: investigating the viral tapestry of activation.

Infectious agents and cancer
2024

Cannabinoid receptors as new targets for HTLV-1 associated myelopathy (HAM/TSP) treatment.

Multiple sclerosis and related disorders
2024

Infective dermatitis associated with human T-cell lymphotropic virus type-1, an underdiagnosed disease.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
2024

Assessment of chronic pain and its association with functional capacity in patients with HTLV-1.

Pain medicine (Malden, Mass.)
2024

Complete Rescue of HTLV-1p12KO Infectivity by Depletion of Monocytes Together with NK and CD8+ T Cells.

Pathogens (Basel, Switzerland)
2024

Neurological aspects of HTLV-1 infection: symptoms in apparently asymptomatic carriers.

Journal of neurovirology
2023

HTLV-1 Proviral Load Absolute RT-qPCR Development for Assessing on Clinical Outcomes in HAM/TSP Patients.

Reports of biochemistry &amp; molecular biology
2024

Non-cancerous complications in HTLV-1 carriers.

Expert review of anti-infective therapy
2024

HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP): Case based discussion of risk factors, clinical, and therapeutic considerations.

Journal of the neurological sciences
2023

Nonpharmacological interventions and outcomes in the management of complications of human T-cell lymphotropic virus type 1-related myelopathy/tropical spastic paraparesis: A systematic review.

Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences
2024

Comprehensive Insight into the Functional Roles of NK and NKT Cells in HTLV-1-Associated Diseases and Asymptomatic Carriers.

Molecular neurobiology
2024

Multicenter, randomized, double-blind, placebo-controlled phase 3 study of mogamulizumab with open-label extension study in a minimum number of patients with human T-cell leukemia virus type-1-associated myelopathy.

Journal of neurology
2024

Association between Brain White Matter Lesions and Disease Activity in HAM/TSP Patients.

Neurology international
2024

Mycophenolate mofetil for the long-term treatment of HTLV-1 associated myelopathy: A case report.

Journal of neuroimmunology
2024

Determination of molecular epidemiologic pattern of human T-lymphotropic virus type 1 (HTLV-1) in Alborz province, Iran.

Virus genes
2024

HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors.

Virology journal
2024

An HTLV-1 envelope mRNA vaccine is immunogenic and protective in New Zealand rabbits.

Journal of virology
2024

HTLV-1 induces an inflammatory CD4+CD8+ T cell population in HTLV-1-associated myelopathy.

JCI insight
2023

A Textbook Case of Human T-lymphotropic Virus-1 (HTLV-1)-Induced Adult T-cell Leukemia Treated With Cyclophosphamide, Hydroxydaunorubicin, Oncovin, and Prednisone/Prednisolone (CHOP).

Cureus
2024

Anti-HTLV-1 immunity combined with proviral load as predictive biomarkers for adult T-cell leukemia-lymphoma.

Cancer science
2023

Advances in the treatment of human T-cell lymphotropic virus type-I associated myelopathy.

Expert review of neurotherapeutics
2023

Natural Selection Signatures in the Hondo and Ryukyu Japanese Subpopulations.

Molecular biology and evolution
2023

Decoding dysregulated angiogenesis in HTLV-1 asymptomatic carriers compared to healthy individuals.

Medical oncology (Northwood, London, England)
2023

Physiotherapy Methods Applied in the Prevention of Functional Loss Associated with Human T-Lymphotropic Virus 1 Infection: An Overview.

Infectious disease reports
2023

Differential modulation of IL-4, IL-10, IL-17, and IFN-γ production mediated by IgG from Human T-lymphotropic virus-1 (HTLV-1) infected patients on healthy peripheral T (CD4+, CD8+, and γδ) and B cells.

Frontiers in medicine
2023

T helper type 9 cell response and its role in the neurological clinic of patients with Human T-lymphotropic virus 1.

Immunobiology
2023

HTLV-1 p12 modulates the levels of prion protein (PrPC) in CD4+ T cells.

Frontiers in microbiology
2023

Viral Immune signatures from cerebrospinal fluid extracellular vesicles and particles in HAM and other chronic neurological diseases.

Frontiers in immunology
2023

Tropical spastic paraparesis.

Handbook of clinical neurology
2023

Patient research priority setting partnership in human T-cell lymphotropic virus type I.

Health expectations : an international journal of public participation in health care and health policy
2023

Retroviral b-Zip protein (HBZ) contributes to the release of soluble and exosomal immune checkpoint molecules in the context of neuroinflammation.

Journal of extracellular biology
2023

The mirror like expression of genes involved in the FOXO signaling pathway could be effective in the pathogenesis of human lymphotropic virus type 1 (HTLV-1) through disruption of the downstream pathways.

BMC research notes
2023

Investigating the effect of MAP2K1 gene (MEK1) in MAPK pathway in the induction of adult T-cell leukemia/lymphoma (ATLL).

Iranian journal of microbiology
2023

Performance of the National Institute of Infectious Diseases disability scale in HTLV-1-associated myelopathy/tropical spastic paraparesis.

Journal of neurovirology
2023

Could Cesarean Delivery Help Prevent Mother-to-Child Transmission of Human T-Lymphotropic Virus Type 1?

The Journal of infectious diseases
2023

Human T-cell leukemia virus type 1 is associated with dysthyroidism in the French Amazon.

Frontiers in cellular and infection microbiology
2023

Pentraxin 3, a serum biomarker in human T-cell lymphotropic virus type-1-associated myelopathy patients and asymptomatic carriers.

Medical microbiology and immunology
2023

Mechanisms of Innate Immune Sensing of HTLV-1 and Viral Immune Evasion.

Pathogens (Basel, Switzerland)
2023

HTLV-1 Proviral Load in Vaginal Fluid Correlates with Levels in Peripheral Blood Mononuclear Cells.

Pathogens (Basel, Switzerland)
2023

Cognitive deficits in HTLV-1 patients.

Journal of neurovirology
2023

Putative role of HLA polymorphism among a Brazilian HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) population.

Scientific reports
2023

Mogamulizumab for Treatment of Human T-lymphotropic Virus Type 1-Associated Myelopathy/Tropical Spastic Paraparesis: A Single-Center US-based Series.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2023

Detection of HTLV-1 proviral DNA in cell-free DNA: Potential for non-invasive monitoring of Adult T cell leukaemia/lymphoma using liquid biopsy?

Frontiers in immunology
2023

Iliopsoas Muscle Weakness as a Key Diagnostic Marker in HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP).

Pathogens (Basel, Switzerland)
2023

How Can We Prevent Mother-to-Child Transmission of HTLV-1?

International journal of molecular sciences
2023

Signs and symptoms of human T-lymphotropic virus 1 and 2 infections in paediatric patients.

Tropical medicine &amp; international health : TM &amp; IH
2023

Long-term safety and efficacy of mogamulizumab (anti-CCR4) for treating virus-associated myelopathy.

Brain : a journal of neurology
2023

Vaginal dryness in women infected by human T-lymphotropic virus type 1: an exploratory study.

Sexual medicine
2023

Impaired flexibility in patients with tropical spastic paraparesis/HTLV-associated myelopathy: evaluation via pendulum fleximeter.

Arquivos de neuro-psiquiatria
2023

Identification and tracking of HTLV-1-infected T cell clones in virus-associated neurologic disease.

JCI insight
2023

Apigenin improves cytotoxicity of antiretroviral drugs against HTLV-1 infected cells through the modulation of AhR signaling.

NeuroImmune pharmacology and therapeutics
2023

Severe mitral regurgitation in chronic adult T-cell leukemia/lymphoma with granulomatous valvular inflammation.

Journal of cardiology cases
2023

HAM/TSP Pathogenesis: The Transmigration Activity of HTLV-1-Infected T Cells into Tissues.

Pathogens (Basel, Switzerland)
2023

Th17/IL-17 Axis in HTLV-1-Associated Myelopathy Tropical Spastic Paraparesis and Multiple Sclerosis: Novel Insights into the Immunity During HAMTSP.

Molecular neurobiology
2023

Precise excision of HTLV-1 provirus with a designer-recombinase.

Molecular therapy : the journal of the American Society of Gene Therapy
2023

HTLV-1-associated demyelinating neuropathy: A case report and review of the literature.

eNeurologicalSci
2023

Infection of the Ex Vivo Tonsil Model by HTLV-1 Envelope-Pseudotyped Viruses.

Pathogens (Basel, Switzerland)
2023

Geographic distribution, clinical epidemiology and genetic diversity of the human oncogenic retrovirus HTLV-1 in Africa, the world's largest endemic area.

Frontiers in immunology
2023

Cost-effectiveness of human T-cell leukemia virus type 1 (HTLV-1) antenatal screening for prevention of mother-to-child transmission.

PLoS neglected tropical diseases
2023

Human T-cell Leukemia Virus Type 1 (HTLV-1)-induced Uveitis.

Ocular immunology and inflammation
2022

Safety of intraocular anti-VEGF antibody treatment under in vitro HTLV-1 infection.

Frontiers in immunology
2023

Evolution of erectile dysfunction in individuals infected with human T-lymphotropic virus 1: a prospective cohort study.

The journal of sexual medicine
2023

Pathogenicity and virulence of human T lymphotropic virus type-1 (HTLV-1) in oncogenesis: adult T-cell leukemia/lymphoma (ATLL).

Critical reviews in clinical laboratory sciences
2023

XCL1, a serum biomarker in neurological diseases; HTLV-1-associated myelopathy and multiple sclerosis.

Microbial pathogenesis
2023

Seroprevalence of maternal peripartum human T-cell lymphotropic virus type-1 infection: a systematic review and meta-analysis of the Nigerian literature.

Clinical and experimental pediatrics
2023

Efficacy of l-Arginine treatment in patients with HTLV-1-associated neurological disease.

Annals of clinical and translational neurology
2022

A newly identified interaction between nucleolar NPM1/B23 and the HTLV-I basic leucine zipper factor in HTLV-1 infected cells.

Frontiers in microbiology
2022

Systemic cytokines and GlycA discriminate disease status and predict corticosteroid response in HTLV-1-associated neuroinflammation.

Journal of neuroinflammation
2022

Postural Adjustments in HTLV-1 Infected Patients during a Self-Initiated Perturbation.

Viruses
2022

Comparison of Static Balance Control in Infected Htlv-1 Subjects with Different Tsp/Ham Diagnosis.

Viruses
2022

Particularities of Neurological Manifestations in Adult T-Cell Leukemia/Lymphoma: Need for a Multidisciplinary Approach-A Narrative Review.

Medicina (Kaunas, Lithuania)
2022

Establishment of a Cynomolgus Macaque Model of Human T-Cell Leukemia Virus Type 1 (HTLV-1) Infection by Direct Inoculation of Adult T-Cell Leukemia Patient-Derived Cell Lines for HTLV-1 Infection.

Journal of virology
2022

TNF-induced metalloproteinase-9 production is associated with neurological manifestations in HTLV-1-infected individuals.

Frontiers in immunology
2022

Development of a Monoclonal Antibody Targeting HTLV-1 Envelope gp46 Glycoprotein and Its Application to Near-Infrared Photoimmuno-Antimicrobial Strategy.

Viruses
2022

Lessons from the Cerebrospinal Fluid Analysis of HTLV-1-Infected Individuals: Biomarkers of Inflammation for HAM/TSP Development.

Viruses
2022

Hijacking Host Immunity by the Human T-Cell Leukemia Virus Type-1: Implications for Therapeutic and Preventive Vaccines.

Viruses
2022

T cell receptor repertoire analysis in HTLV-1-associated diseases.

Frontiers in immunology
2022

Co-Infection and Cancer: Host-Pathogen Interaction between Dendritic Cells and HIV-1, HTLV-1, and Other Oncogenic Viruses.

Viruses
2022

MiR-150 in HTLV-1 infection and T-cell transformation.

Frontiers in immunology
2022

Chitotriosidase 1 in the cerebrospinal fluid as a putative biomarker for HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) progression.

Frontiers in immunology
2022

Selective APC-targeting of a novel Fc-fusion multi-immunodominant recombinant protein (tTax-tEnv:mFcγ2a) for HTLV-1 vaccine development.

Life sciences
2022

Phenotypic and functional analysis of γδ T cells in the pathogenesis of human T-cell lymphotropic virus type 1 infection.

Frontiers in immunology
2022

Probable HTLV-I/II Tropical Spastic Paraparesis Patient from Ethiopia: A Case Report.

Ethiopian journal of health sciences
2022

Work ability and associated factors in people living with human T-cell leukemia virus type 1.

Revista da Sociedade Brasileira de Medicina Tropical
2022

Is the HTLV-1 Retrovirus Targeted by Host Restriction Factors?

Viruses
2022

Effect of HTLV-1 Infection on the Clinical Course of Patients with Rheumatoid Arthritis.

Viruses
2022

Making Visible HTLV Infection in a Non-endemic Area of Argentina.

Frontiers in medicine
2022

An Overview of Human T-Lymphotropic Virus Type 1 Lung Injury.

Frontiers in immunology
2022

Human T Lymphotropic Virus 1-Associated Myelopathy: Overview of Human T Cell Lymphotropic Virus-1/2 Tests and Potential Biomarkers.

AIDS research and human retroviruses
2022

The Road to HTLV-1-Induced Leukemia by Following the Subcellular Localization of HTLV-1-Encoded HBZ Protein.

Frontiers in immunology
2022

Rapid and Sensitive Qualitative Duoplex Real-Time PCR Method for Discriminatory and Confirmatory Diagnosis of HTLV-1 and HTLV-2 Infections: Brazilian Multicentric Study.

Frontiers in medicine
2022

Integrative and Multidisciplinary Care for People Living With Human T-Cell Lymphotropic Virus in Bahia, Brazil: 20 Years of Experience.

Frontiers in medicine
2022

Association of the p75NTR Ser205Leu Polymorphism with Asymptomatic HTLV-1 Infection.

Viruses
2022

HTLV, a multi organ oncovirus.

Microbial pathogenesis
2022

Factors Involved in Pain Perception and Quality of Life in Patients with Tropical Spastic Paraparesis.

Revista da Sociedade Brasileira de Medicina Tropical
2022

Identification of hub genes and molecular pathways in human T-lymphotropic virus type 1 associated diseases using protein-protein interactions networks.

Iranian journal of microbiology
2022

The Past, Present, and Future of a Human T-Cell Leukemia Virus Type 1 Vaccine.

Frontiers in microbiology
2022

The Expression of Tax and HBZ Genes in Serum-Derived Extracellular Vesicles From HTLV-1 Carriers Correlates to Proviral Load and Inflammatory Markers.

Frontiers in microbiology
2022

Human T-lymphotropic virus type 1 and novel coronavirus disease 2019; More complex than just a simple coinfection.

Gene
2022

Cabotegravir, the Long-Acting Integrase Strand Transfer Inhibitor, Potently Inhibits Human T-Cell Lymphotropic Virus Type 1 Transmission in vitro.

Frontiers in medicine
2022

Current Perspectives in Human T-Cell Leukemia Virus Type 1 Infection and Its Associated Diseases.

Frontiers in medicine
2022

Updates on HTLV-1 Uveitis.

Viruses
2022

Evaluation of antioxidant status and oxidative stress markers in HTLV-1 infected individuals: correlation with the severity of virus-induced complications.

Journal of medical microbiology
2022

Cardiovascular risk factors and brain white matter lesions in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP).

Journal of neurovirology
2022

Clinical and Public Health Implications of Human T-Lymphotropic Virus Type 1 Infection.

Clinical microbiology reviews
2022

Regulation of HTLV-1 transformation.

Bioscience reports
2022

Cognitive screening in HTLV-1-infected people using a self-perceived memory score and auditory P300.

Journal of neurovirology
2022

Frequency and characteristics of HTLV in migrants: results from the +Redivi collaborative network in Spain.

Journal of travel medicine
2022

HIV-1 and HTLV-1 Transmission Modes: Mechanisms and Importance for Virus Spread.

Viruses
2022

Human T-Cell Leukemia Virus Type 1 Envelope Protein: Post-Entry Roles in Viral Pathogenesis.

Viruses
2022

Integration of gene co-expression analysis and multi-class SVM specifies the functional players involved in determining the fate of HTLV-1 infection toward the development of cancer (ATLL) or neurological disorder (HAM/TSP).

PloS one
2022

Monitoring of HTLV-1-associated diseases by proviral load quantification using multiplex real-time PCR.

Journal of neurovirology
2021

Nanomicellar Curcumin Supplementation Improves the Clinical Manifestations of HAM/TSP Patients.

Advances in experimental medicine and biology
2022

Cerebral and spinal cord changes observed through magnetic resonance imaging in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis: a systematic review.

Journal of neurovirology
Ver todos os 578 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Self-management of HTLV-1-associated myelopathy/tropical spastic paraparesis in Japan: A qualitative study.
    PLoS neglected tropical diseases· 2026· PMID 41855158mais citado
  2. Urine Metabolomics and Machine Learning Identify Metabolic Features and Potential Biomarkers of HTLV-1-Associated Myelopathy (HAM).
    International journal of molecular sciences· 2026· PMID 41751961mais citado
  3. Assessment of Awareness and Knowledge Regarding Human T-Lymphotropic Virus Type 1 (HTLV-1) Among Healthcare Workers at Imam Khomeini Hospital Complex, Tehran, in 2023-2024, A Cross-Sectional Descriptive-Analytical Study.
    Health science reports· 2026· PMID 41737423mais citado
  4. Epidemiology of adult T-cell leukemia/lymphoma (ATL) in people living with HTLV-1: A 30-year study in Peru.
    PLoS neglected tropical diseases· 2026· PMID 41729993mais citado
  5. Dimethyl fumarate as a promising therapeutic candidate for virus-associated myelopathy.
    Brain : a journal of neurology· 2026· PMID 41642278mais citado
  6. HTLV1-associated myelopathy as a translational model of progressive neurodegeneration.
    Brain· 2026· PMID 41926707recente
  7. Interferon dynamics in deltaretroviruses: why HTLV-1 evades, but BLV responds.
    Mol Biol Rep· 2026· PMID 41920397recente
  8. Acanthamoeba myelopathy mimicking tropical spastic paraparesis in immunocompetent hosts: a case series.
    Neurol Sci· 2026· PMID 41760966recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:289326(Orphanet)
  2. OMIM OMIM:159580(OMIM)
  3. MONDO:0008039(MONDO)
  4. GARD:8208(GARD (NIH))
  5. Busca completa no PubMed(PubMed)
  6. Artigo Wikipedia(Wikipedia)
  7. Q1476361(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Paraparesia espástica tropical
Compêndio · Raras BR

Paraparesia espástica tropical

ORPHA:289326 · MONDO:0008039
Prevalência
Unknown
Herança
Not applicable
CID-10
G04.1 · Paraplegia espástica tropical
CID-11
Ensaios
1 ativos
Início
Adult
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0030481
EuropePMC
Wikidata
Wikipedia
Papers 10a
Evidência
🥉 Relato de caso
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