É uma condição causada por autoanticorpos, que são defesas do corpo que, por engano, atacam a si mesmas. Esses autoanticorpos agem contra os fosfolipídios (certas gorduras presentes nas células), o que faz o sangue coagular mais do que deveria. Isso pode levar à formação de coágulos, derrame (AVC), infarto e, em mulheres, a problemas sérios na gravidez, como aborto espontâneo e perda do bebê antes ou durante o parto (natimorto). Essa síndrome costuma estar ligada a outras doenças autoimunes, sendo a mais comum o lúpus, e também a infecções, como sífilis e doença de Lyme.
Introdução
O que você precisa saber de cara
É uma condição causada por autoanticorpos, que são defesas do corpo que, por engano, atacam a si mesmas. Esses autoanticorpos agem contra os fosfolipídios (certas gorduras presentes nas células), o que faz o sangue coagular mais do que deveria. Isso pode levar à formação de coágulos, derrame (AVC), infarto e, em mulheres, a problemas sérios na gravidez, como aborto espontâneo e perda do bebê antes ou durante o parto (natimorto). Essa síndrome costuma estar ligada a outras doenças autoimunes, sendo a mais comum o lúpus, e também a infecções, como sífilis e doença de Lyme.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 40 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 80 características clínicas mais associadas, ordenadas por frequência.
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Genética e causas
O que está alterado no DNA e como passa nas famílias
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Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
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Mostrando amostra de 200 publicações de um total de 4.783
Magnetic Resonance Imaging-Negative Lupus Myelitis: A Narrative Review.
Magnetic resonance imaging (MRI)-negative lupus myelitis (MNLM) is a rare neurological manifestation of systemic lupus erythematosus (SLE). Diagnosing MNLM without prior systemic involvement remains challenging. This review aims to analyze all published cases and compare MNLM patients with (Group A) and without prior SLE diagnosis (Group B), emphasizing on demographic and clinical profiles, treatment, and outcomes. A PubMed literature review on MNLM was conducted. Demographic profile, clinical presentations, and management were analyzed. MNLM patients were categorized into Group A and B and compared using univariate and multivariate comparison methods, where a P value <0.05 was considered significant. In total, 41 cases were analyzed. The cohort was predominantly female (8:1 ratio, mean age 31.22 ± 11.91 years, range 15-59 years). Thoracic cord involvement was the most common (55%), with myelitis presenting as the first manifestation in 49% of patients. Clinical presentations were predominantly subacute (71%) with partial tract involvement in 63%. Group A demonstrated significantly higher cervical cord localization (P = 0.019) compared to Group B's thoracic involvement (P = 0.041). Antiphospholipid syndrome (APS) antibody-positive patients showed 3.2-fold higher odds for partial recovery (P = 0.16). Logistic regression analysis identified Anti Smith/ Ribonucleoprotein/ Ribosomal (Sm/RNP/Rib) antibodies as independent risk factors for poor complete recovery (odds ratio (OR) = 0.61), whereas cervical cord localization independently improved odds for complete recovery (OR = 3.2). MNLM presents with variable clinical manifestations suggesting selective tract involvement. Group A exhibits higher cervical involvement, while Group B shows predominantly thoracic involvement. APS antibodies favor partial recovery, cervical localization predicts complete recovery, and Sm/RNP/Rib antibodies are independent predictors of poor recovery outcomes.
A Common Missense Variant, W335S, in β2-Glycoprotein I (APOH) is Associated with Increased Autoantibody Levels but Reduced Venous Thromboembolism Risk.
Anti-β2-glycoprotein I (anti-β2GPI) antibodies are central to the pathogenesis of antiphospholipid syndrome (APS), an autoimmune disease characterized by a strong predisposition to venous thromboembolism (VTE). In this study, we conducted a multi-ancestry genome-wide association study (GWAS) of quantitative total anti-β2GPI levels in 5,969 participants enrolled in the Multi-Ethnic Study of Atherosclerosis (MESA) and identified a genome-wide significant association at the APOH locus. Paradoxically, genetically determined increases in anti-β2GPI levels at this locus were associated with lower VTE risk. Fine-mapping and functional genomics prioritized the missense variant rs1801690 (W335S) in β2GPI (apolipoprotein H, [APOH]) as the most likely causal variant. This variant has an allele frequency of 5-6% in European and East Asian ancestries but only 1% in African ancestries. Integrating prior experimental studies, molecular dynamics simulations and structure-based epitope prediction, we propose a dual-effect mechanism whereby W335S reduces thrombotic risk by disrupting phospholipid binding in Domain V, yet increases autoantibody production through conformational changes that enhance epitope exposure in Domains I and II. These findings mechanistically uncouple autoantibody formation from thrombotic risk in carriers of the W335S variant, and suggest that APOH genotype may represent a clinically relevant genetic biomarker with potential utility for thrombotic risk stratification in anti-β2GPI-positive individuals.
Hyperbaric oxygen therapy for post-partum bell's palsy associate with anti-phospholipid syndrome: a case report, literature review, and mechanistic insights.
Bell's palsy, the most common cause of acute facial paralysis, can occur more frequently during pregnancy and postpartum due to physiological changes such as fluid retention, hormonal shifts, and immune modulation. Antiphospholipid syndrome (APS), an autoimmune disorder characterized by thrombosis and pregnancy related complications, further increases the risk of microvascular ischemia affecting cranial nerves. We report the case of a 37-year-old woman with longstanding APS who developed postpartum Bell's palsy unresponsive to corticosteroid therapy. Despite receiving 60 mg of prednisone, no clinical improvement was noted. Hyperbaric oxygen therapy (HBOT) was initiated, prescribed for 20 sessions at 2 absolute atmospheres, 5 days per week. Remarkable improvement was observed after the first session, with complete symptom resolution by the twelfth session. Additionally, anti-dsDNA antibodies, previously positive during pregnancy, became negative following HBOT. HBOT may represent a valuable adjunctive treatment for postpartum Bell's palsy in high-risk populations such as those with APS, offering combined benefits of enhanced oxygenation, inflammation control, and vascular repair. Further prospective studies are warranted to validate these findings and define standardized treatment protocols.
Perioperative Management of Antithrombotic Therapy in Patients with Thrombotic Antiphospholipid Syndrome.
Patients with thrombotic antiphospholipid syndrome (APS) frequently require interruption of anticoagulation for invasive procedures, yet data to guide perioperative management remain limited. We conducted a single-center retrospective cohort study of adults with thrombotic APS who underwent planned periprocedural interruption of anticoagulation between 2016 and 2025. Primary outcomes were the 30-day risks of arterial thromboembolism (ATE), venous thromboembolism (VTE), and major bleeding; secondary outcomes included clinically relevant non-major bleeding (CRNMB), microvascular APS manifestations, and catastrophic APS (CAPS). Among 172 patients undergoing 282 interruptions, most (84.9%) received warfarin, and 25% were triple-positive (anti-cardiolipin, anti-β2-glycoprotein I, and lupus anticoagulant). Bridging with low-molecular-weight heparin (LMWH) was used in 84.7% of warfarin interruptions. Therapeutic-dose bridging was more frequently used in patients with triple-positive APS (OR 7.6; 95%CI 3.2-18.2) and in those with prior ATE (OR 3.4; 95%CI 1.5-7.8). The 30-day risk of ATE was 0.7% (95%CI 0.2-2.6). Major bleeding occurred in 0.7% (95%CI 0.2-2.6), with both events following high-bleed-risk procedures. One bleeding event was fatal, corresponding to a mortality risk of 0.4% (95%CI 0.1-2.0). CRNMB occurred in 3.2% (95%CI 1.7-6.0). A single case of probable CAPS occurred in a triple-positive patient receiving postoperative prophylactic LMWH. Guideline-directed perioperative anticoagulation management tailored to individual thrombotic and procedural bleeding risks appears feasible and safe. Our findings support individualized, risk-adapted perioperative anticoagulation management in APS.
Are there disparities in cerebral sinus venous thrombosis between the Arab and Jewish populations in Israel - a multicenter cohort study?
Cerebral sinus venous thrombosis (CSVT) is a rare stroke subtype and data regarding the impact of ethnicity on its presentation and outcomes are limited. The Israeli CSVT cohort, which includes databases from six academic medical centers, was retrospectively studied. Demographics, clinical presentations, risk factors, radiological findings, and outcome parameters were compared between Jewish and Arab Israeli patients. The study included 554 patients with CSVT, of whom 71 (13%) were of Arab ethnicity and 483 (87%) were Jewish. Arab patients were younger (mean age 38.4 ± 15.8 vs. 42.8 ± 10.1 years, p = 0.027), and more frequently male (48% vs. 33%, p = 0.013). Rates of Behcet's disease (BD) were higher among Arabs patients (13% vs. 3%, p < 0.001), antiphospholipid syndrome (23% vs. 10%, p = 0.002) and any coagulopathy (48% vs. 35%, p = 0.04), but lower rates of hypertension (4% vs. 15%, p = 0.016), and use of oral contraceptives (9% vs. 26%, p = 0.002). Differences in clinical presentation included higher rates of headache (90% vs. 74%, p = 0.004) and vomiting (39% vs. 15%, p < 0.001) in the Arab patient group. Arab ethnicity was associated with lower rates of any recanalization (aOR 0.346 [0.172-0.695], p = 0.003), and complete recanalization (aOR 0.408 [0.209-0.795], p = 0.008). Despite these differences, rates of favorable outcomes, mortality, and CSVT recurrence were similar between the groups. The findings highlight notable ethnic variations in the risk factors and clinical manifestations of CSVT between Arab and Jewish populations living in the same physical surroundings. Understanding these ethnic differences is crucial for creating targeted prevention and treatment strategies that cater to the specific needs of these diverse groups.
Publicações recentes
Clinical Interpretation of Platelet Activation Marker sCLEC-2 in Antiphospholipid Syndrome.
Contraception in Women With Medical Comorbidities: Clinical Risk Stratification and Individualized Therapeutic Strategies.
Ultrastructural Injury of Renal Podocytes in Catastrophic Antiphospholipid Syndrome.
Do ethnoracial differences exist among antiphospholipid antibody-positive patients with no other systemic autoimmune diseases: results from the APS ACTION registry.
Antiphospholipid Syndrome and Cardiovascular Disease.
📚 EuropePMC6.356 artigos no totalmostrando 193
Nonbacterial Thrombotic Endocarditis and Mechanical Valve Thrombosis in a Patient with Antiphospholipid Syndrome.
CASE (Philadelphia, Pa.)Magnetic Resonance Imaging-Negative Lupus Myelitis: A Narrative Review.
Annals of Indian Academy of NeurologyDo Patients with Antiphospholipid Syndrome Present with More Significant Venous Thromboembolic Clot Burden? A Retrospective Single-Center Study.
Hematology reportsGenetic determinants of arterial thrombosis in primary antiphospholipid syndrome: a systematic review.
Frontiers in immunologyCase Report: Differential diagnosis and clinical management of isolated prolonged activated partial thromboplastin time.
Frontiers in immunologyRNA sequencing-derived gene co-expression and drug-gene interaction analysis reveal STAT1 as a potential therapeutic target in thrombotic antiphospholipid syndrome.
Frontiers in immunologyA Common Missense Variant, W335S, in β2-Glycoprotein I (APOH) is Associated with Increased Autoantibody Levels but Reduced Venous Thromboembolism Risk.
medRxiv : the preprint server for health sciencesReversible Clozapine-Induced Antiphospholipid Syndrome.
The primary care companion for CNS disordersHyperbaric oxygen therapy for post-partum bell's palsy associate with anti-phospholipid syndrome: a case report, literature review, and mechanistic insights.
Frontiers in rehabilitation sciencesMonoclonal Gammopathies of Thrombotic and Hemorrhagic Significance: Mapping into a classification schema.
Journal of thrombosis and haemostasis : JTHAcute Myocardial Infarction Secondary to Triple Vessel Coronary Artery Disease in a 31-year-old Female with Systemic Lupus Erythematosus: Case Report and Review of Literature.
Acta medica PhilippinaAngiogenic imbalance and endothelial dysfunction in the placenta in antiphospholipid syndrome.
Autoimmunity reviewsPerioperative Management of Antithrombotic Therapy in Patients with Thrombotic Antiphospholipid Syndrome.
Blood advancesAcute Ischemic Stroke as the Initial Manifestation of Antiphospholipid Syndrome After SARS-CoV-2 Infection in a 17-Year-Old Patient.
CureusCriterion and non-criteria antiphospholipid antibodies and acute coronary syndrome in the adult population under 55 years of age.
Medicina clinicaRespond to "comments and opinions regarding "High antiphospholipid antibody titers and outcomes of pulmonary endarterectomy: a single-center retrospective observational cohort study" by Miard et al.
The Journal of heart and lung transplantation : the official publication of the International Society for Heart TransplantationEffect of SARS-CoV-2 infection on the antiphospholipid antibodies and perinatal outcomes of pregnant patients with antiphospholipid syndrome.
Clinical rheumatologyManagement of patients with antiphospholipid antibodies or antiphospholipid syndrome during pregnancy.
Current opinion in rheumatologyHyposplenism in systemic lupus erythematosus: biological and radiological characteristics and its association with increased risk of infection.
RMD open[A case of antiphospholipid syndrome complicated with hyperhomocysteinemia presenting initially with central retinal vein occlusion in a young male].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmologyCoexistent Antiphospholipid Syndrome with Polycythemia Vera in a 25-year-old Lady Presented with Splenic Vein Thrombosis.
The Journal of the Association of Physicians of IndiaThe role of clot waveform analysis and related parameters in the diagnosis and treatment of systemic lupus erythematosus.
Thrombosis researchAutoimmunity beyond antibodies: alternative roles of beta-2-glycoprotein I in and out of antiphospholipid syndrome?
Current opinion in immunologyAre there disparities in cerebral sinus venous thrombosis between the Arab and Jewish populations in Israel - a multicenter cohort study?
Journal of the neurological sciencesAntiphospholipid antibodies and cardiovascular thrombosis.
Nature reviews. CardiologyNormalization of activated partial thromboplastin time and diluted Russell's viper venom time ratios can be safely omitted in the assessment of lupus anticoagulant.
Research and practice in thrombosis and haemostasisImpact of the 2023 ACR/EULAR antiphospholipid syndrome criteria in 1200 women with prior obstetric antiphospholipid syndrome.
European journal of obstetrics, gynecology, and reproductive biologyThrombotic recurrence after anticoagulation cessation in patients with antiphospholipid syndrome and antiphospholipid antibody negativization: a systematic review & meta-analysis.
Journal of thrombosis and haemostasis : JTHReduction of regulatory B cells is associated with high-risk clinical stratification in antiphospholipid syndrome patients.
Immunologic researchHematologic disorders in pregnancy: the role of the complement system.
Expert review of hematologyBlinatumomab in Combined Immune Thrombocytopenia and Antiphospholipid Syndrome.
The New England journal of medicineCatastrophic Antiphospholipid Syndrome: A Rare but Life-Threatening Thrombotic Storm-A Case Report and Literature Review.
Case reports in rheumatologyEndothelial dysfunction in APS: advancing pathophysiological understanding to improve management.
Current opinion in immunologyMitral Valve Nonbacterial Thrombotic Endocarditis Associated With Antiphospholipid Syndrome in a Male Patient: A Comprehensive Case Report.
Case reports in medicineCriterion validity of the EULAR Antiphospholipid Syndrome Disease Activity Score (EAPSDAS).
Annals of the rheumatic diseasesMyocardial infarction in a child with systemic lupus erythematosus.
BMJ case reportsObstetric antiphospholipid syndrome: Advances in pathogenesis.
Autoimmunity reviewsDiffuse alveolar hemorrhage in antiphospholipid syndrome: Clinical presentation and prognosis.
Respiratory medicineDevelopment of clinical manifestations in individuals positive for antiphospholipid antibodies according to the 2023 ACR/EULAR serological domains.
Seminars in arthritis and rheumatismImplementation of institutional thrombophilia guidelines and electronic medical record tools to reduce inpatient thrombophilia testing and costs.
Thrombosis researchRevisiting antiphospholipid syndrome: A thrombo-inflammatory disorder beyond clotting.
Blood reviewsPulmonary Embolism as a Rare Complication of Anaplasmosis: A Case Report.
CureusComprehensive Review of Antiphospholipid Syndrome: Over Four Decades of Advances and Challenges.
CellsProthrombotic fibrin clot phenotype in obstetric antiphospholipid syndrome: clinical implications and unanswered questions.
Polish archives of internal medicineProthrombotic fibrin clot phenotype in obstetric antiphospholipid syndrome: clinical implications and unanswered questions. Authors' reply.
Polish archives of internal medicineHydroxychloroquine therapy for women with both recurrent pregnancy loss and autoimmune disease: association with pregnancy outcomes and maternal-fetal complications.
Frontiers in immunologyValidation of the 2023 American College of Rheumatology/European League Against Rheumatism antiphospholipid syndrome classification criteria in a Chinese systemic lupus erythematosus cohort.
Chinese medical journalDelayed diagnosis of recurrent embolic strokes from cardiac myxoma coexisting with antiphospholipid syndrome presenting as progressive cognitive decline.
BMJ case reportsMonoclonal gammopathies of cutaneous significance: A nomenclature and pathophysiology-based classification.
Journal of the American Academy of DermatologyQuantifying Lupus Anticoagulant Interference in Intrinsic Coagulation Factor Activity Assays and Evaluating the Corrective Performance of the SCT-Based Method.
Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/HemostasisExpression levels of miR-146a-5p, miR-155-5p and the pro-inflammatory cytokine IL-8 in pregnant women with anti-phospholipid syndrome.
LupusFostamatinib treatment for patients with antiphospholipid syndrome and low platelet count: A case series.
British journal of haematologyMultifocal Osteonecrosis in a Patient With Systemic Lupus Erythematosus and Antiphospholipid Syndrome Associated With Pyoderma Gangrenosum and Other Complications: A Case Report.
Case reports in medicineMultifactorial thrombotic risk in Evans syndrome: a case report and review of the literature.
Thrombosis journalSimvastatin Restores Uteroplacental Hemodynamics and Trophoblast Function in Obstetric Antiphospholipid Syndrome in a Placenta-on-a-Chip Model.
Advanced healthcare materialsCoagulation parameter-based nomogram for the diagnosis of obstetric antiphospholipid syndrome and its subtypes.
Open life sciencesCase Report: Telitacicept in the treatment of cSLE-APS: novel therapeutic perspectives on autoimmune thrombotic diseases in children.
Frontiers in immunologyHistopathological placental findings in antiphospholipid antibody carriers with a fetal loss beyond 12 weeks of pregnancy.
PlacentaaPLs seroconversion in antiphospholipid syndrome: from definition to clinical relevance.
Thrombosis researchAnticoagulation, Recurrent Thrombosis and Major bleeding in antiphospholipid syndrome: UK multicentre observational study.
Blood advancesIschemic Stroke as the First Manifestation of Primary Antiphospholipid Syndrome in a Patient With a Recent Diagnosis of HIV: A Case Report.
CureusAnti-phospholipid antibodies as a risk factor for renal injury in patients with systemic lupus erythematosus: a comprehensive analysis.
Frontiers in immunologyOmadacycline - Associated Anticardiolipin Antibody Positivity and Hypercoagulable State: A Case Report and Review of Tetracycline - Induced Immune Dysregulation.
Infection and drug resistanceExtracellular microvesicles from patients with antiphospholipid syndrome carry antigenic targets and promote endothelial cell activation in vitro.
HaematologicaPreconception Hydroxychloroquine Therapy Restores Placental Function and Improves Pregnancy Outcomes in Obstetric Antiphospholipid Syndrome.
Antioxidants & redox signaling[A clinical case of erythromelalgia in a patient comorbid with antiphospholipid syndrome].
Terapevticheskii arkhivCatastrophic antiphospholipid syndrome in a 39-year-old woman.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienneIncreased placental villous macrophages in patients with antiphospholipid syndrome exacerbated during preterm pregnancy.
PlacentaLupus Anticoagulant and Complement C4 Consumption in Antiphospholipid Antibody Testing: Disentangling Inflammation From Autoimmunity.
International journal of laboratory hematologyIntrapancreatic cysts as a diagnostic clue in antiphospholipid syndrome: a report of three cases.
Gastroenterology reportDon't neglect the non-thrombotic manifestations of antiphospholipid syndrome in children - autoimmune hemolytic anemia and myocarditis: a case report and literature review.
Frontiers in immunologyImplications of 2023 ACR/EULAR classification criteria for antiphospholipid syndrome and current diagnostic and therapeutic insights: A Delphi consensus.
The American journal of medicineIn vivo targeting of open prothrombin with the monoclonal antibody POmAb results in anticoagulation without excessive bleeding.
Journal of thrombosis and haemostasis : JTHTranslational immunothrombosis in autoimmune Heparin-Induced thrombocytopenia: targeting the FcγRIIa-Syk-BTK and complement pathways.
Clinical and experimental medicineConcomitant pulmonary embolism and severe thrombocytopenia associated with an APS-like autoimmune thrombophilic condition: a case report.
BMC pulmonary medicineThrombin Generation Assays in Clinical Hemostasis: From Mechanistic Insights to Clinical Applications.
Seminars in thrombosis and hemostasisIntegrating Anti-Phosphatidylserine/Prothrombin Antibodies Testing into Antiphospholipid Syndrome Diagnostics: A Multidomain, Expert Perception-Based Health Technology Assessment.
Diagnostics (Basel, Switzerland)Why low-dose aspirin persists in recurrent pregnancy loss without APS: cognitive bias and system design.
AJOG global reportsSerum S100A8 as a potential biomarker for diagnosis of antiphospholipid syndrome and risk stratification among aPL carriers.
Lupus science & medicineInherited Thrombophilia as a Risk Factor for Persistent Left Ventricular Thrombus Following Acute Myocardial Infarction.
Thrombosis and haemostasisComplement involvement in antiphospholipid syndrome.
Immunology lettersAnimal models of antiphospholipid syndrome.
Frontiers in immunologyDirect oral anticoagulants versus Vitamin K antagonist in kidney transplant recipients with atrial fibrillation: A study from a global federated research network.
European journal of internal medicineUncommon clinical presentations and diagnostic difficulties of antiphospholipid syndrome associated with cryptococcal meningitis: A case study.
Medical mycology case reportsImaging features of catastrophic antiphospholipid syndrome : Massive saddle pulmonary embolism with subsequent complete resolution.
Radiology case reportsAntiphospholipid Syndrome in Orthopaedic Foot and Ankle Surgery: A Propensity-Matched Analysis.
Foot & ankle orthopaedicsCo-Occurrence of Psoriasis/Psoriatic Arthritis and Antiphospholipid Syndrome: A Series of Nine Patients from a Single Centre and Literature Review.
Mediterranean journal of rheumatologyThe impact of anti-phosphatidylserine/prothrombin antibodies on pregnancy outcomes in patients with unexplained recurrent implantation failure: a retrospective cohort study.
Frontiers in immunologyRecurrent venous thrombosis in an adolescent male with CBS mutation and persistent antiphospholipid antibody positivity: a case report.
Thrombosis journalParallel improvement of chorea and antiphospholipid autoimmunity during combination therapy with hydroxychloroquine, belimumab, and glucocorticoids in systemic lupus erythematosus.
Modern rheumatology case reportsPulmonary Embolism and Myocardial Infarction With Non-obstructive Coronary Arteries in Immune Thrombocytopenia: Unmasking Underlying Antiphospholipid Syndrome.
CureusCatastrophic antiphospholipid syndrome with eosinophilia mimicking hypereosinophilic syndromes with disseminated intravascular coagulation: a case report.
Journal of medical case reportsAntiphosphatidylserine/prothrombin antibodies define a high-risk antiphospholipid syndrome profile associated with organ damage.
Clinical chemistry and laboratory medicineCaveolin-1 as a Marker of Endothelial Damage in Primary Antiphospholipid Syndrome Nephropathy.
Kidney medicineAnticoagulation Management of Patients with Antiphospholipid Syndrome Undergoing Cardiopulmonary Bypass in Cardiac Surgery: Challenges and Current Strategies.
Seminars in thrombosis and hemostasisNavigating clinical overlap: A case of polyarteritis nodosa in the setting of antiphospholipid syndrome.
Modern rheumatology case reportsPulmonary endarterectomy in antiphospholipid syndrome: a retrospective analysis from the Saudi pulmonary hypertension registry.
Frontiers in medicineNon-Huntington's disease chorea: an expanding universe with acquired causes.
Brain : a journal of neurologyExploring the prognostic significance of antiphospholipid antibody in acute myocardial infarction: insights from clinical study and mechanism.
Journal of thrombosis and haemostasis : JTHMolecular determinants of allosteric modulation of protein disulfide isomerase by small-molecule b'-ligands.
Redox biologyPopulation developmental hazard of over-the-counter NSAIDs.
Folia medica CracoviensiaCatastrophic antiphospholipid syndrome: Clinical characteristics and outcomes in a non-caucasian population - A five-year experience from a single centre.
Lupus[Research progress on risk factors and risk prediction of cardiovascular diseases related to antiphospholipid syndrome].
Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine]Activated Protein C Sensitivity Assessed with Thrombin Generation Assay in Antiphospholipid Syndrome Women: Results from Two French Cohorts.
Thrombosis and haemostasisCatastrophic Antiphospholipid Syndrome.
Seminars in thrombosis and hemostasisEthnic differences in disease activity among patients with systemic lupus erythematosus in a universal public healthcare system.
LupusA study of three-time-point dynamic changes in aPS/PT and standard aPL antibodies and their association with IVF pregnancy outcomes in APS-related recurrent pregnancy loss.
Frontiers in medicinePrimary antiphospholipid syndrome presenting with unilateral renal infarction and C4d-positive cortical necrosis: a case report with a pooled analysis of 24 cases.
Frontiers in immunologyAntigenic assessment for the β2-glycoprotein I/Platelet factor 4 complex in thrombotic patients with antiphospholipid syndrome.
Frontiers in immunologyPulmonary Embolism in Antiphospholipid Syndrome (APS)-Where Are We and Where Are We Going?
International journal of molecular sciencesDistribution of Thrombophilia-Related Genetic Polymorphisms in Women with Reproductive Disorders.
BiomedicinesVaccine-Induced Immune Thrombotic Thrombocytopenia (VITT)-like Syndrome: A Case Report and Some Considerations on a Novel Diagnostic and Therapeutic Challenge.
Diagnostics (Basel, Switzerland)Thrombotic Storm: A Challenging Case of Catastrophic Antiphospholipid Syndrome.
CureusPatient partnership model in rare and complex rheumatological conditions: research and beyond in European Reference Network ReCONNET.
The Lancet. RheumatologyDiGeorge Syndrome Complicated by Secondary Antiphospholipid Syndrome Presenting With Vascular Thrombosis.
Clinical case reportsTerrible APS - a newly defined variant of severe APS.
Frontiers in immunologyPrimary antiphospholipid syndrome complicated by recurrent acute ST-elevation myocardial infarction: a case report.
Frontiers in cardiovascular medicineThe diagnostic and prognostic values of non-criteria antiphospholipid antibodies in obstetric antiphospholipid syndrome.
BMC pregnancy and childbirthCD40-CD40L inhibition attenuates platelet-neutrophil interaction and neutrophil extracellular trap release in primary antiphospholipid syndrome.
Annals of the rheumatic diseasesRisk factors for venous thromboembolism in Slovenian children and adolescents: a single center experience.
Frontiers in pediatricsA Case Report of Discoid Lupus Erythematosus Mimicking Skin Infection.
Reports (MDPI)Adrenal Crisis Masquerading as Sepsis in a Patient With Autoimmune Multimorbidity: A Diagnostic Challenge on the Acute Medical Ward.
CureusProton Pump Inhibitor-Induced Fundic Gland Polyps With Massive Bleeding Regressed on Alternative Histamine 2 Receptor Antagonist Therapy.
DEN openOutcomes of assisted reproductive technology in patients with immune-mediated rheumatic diseases: A systematic review and meta-analysis.
Journal of reproductive immunologyAnnexins and autoantibodies in autoimmune diseases - Insights into SLE, APS and RA: A review.
Biomolecules & biomedicineAntiphospholipid Syndrome Mimicking Acute Exacerbation of Interstitial Pneumonia: A Case Report and Literature Review.
Respirology case reportsManaging Pregnancy in the Presence of Rheumatic Heart Disease and Antiphospholipid Syndrome.
JACC. Case reportsFunctional imaging reveals cerebral microvascular dysfunction in primary antiphospholipid syndrome: Pathophysiologic insights and translational implications.
Journal of the neurological sciencesNicotinamide Riboside Mitigates Antiphospholipid Antibody-Induced Dysfunction in Human Trophoblast Cells.
American journal of reproductive immunology (New York, N.Y. : 1989)Surgical treatment of a giant aneurysm of the superior mesenteric artery in a patient with systemic lupus erythematosus.
Journal of surgical case reportsClinical features of non-criteria obstetric antiphospholipid syndrome: a retrospective cohort study on antibody-based risk classification and pregnancy outcomes.
BMC pregnancy and childbirthPrevalence, incidence proportion and independent predictors of thromboembolic events in adults with antiphospholipid syndrome: A systematic review with meta-analysis.
PhlebologyBilateral Adrenal Hemorrhage in Systemic Lupus Erythematosus and Antiphospholipid Syndrome: A Review of Mechanisms, Diagnosis, and Clinical Outcomes.
CureusComplement activation and altered fibrin clot properties in obstetric antiphospholipid syndrome: impact on thromboembolism and pregnancy.
Clinical rheumatology[Chinese guidelines on clinical application of antiphospholipid antibodies (2026 edition)].
Zhonghua nei ke za zhiSuccessful Treatment of a Patient with Neuropsychiatric Lupus and Triple Positive Antiphospholipid Syndrome with Chronic Isolated Seizure: A Case Report.
Acta medica PhilippinaComplicated Pregnancy in a Patient with Distal Renal Tubular Acidosis, Systemic Lupus Erythematosus, and Antiphospholipid Syndrome: A Rare Case and Management Strategies.
Acta medica IndonesianaNavigating obstetric antiphospholipid syndrome: pathophysiology, diagnosis, and therapeutic advances.
Expert review of clinical immunologyElevated neutrophil-to-lymphocyte ratio and the incidence of autoimmune diseases: evidence from a large prospective cohort study.
Scientific reportsTemporal trends in lupus pregnancy over four decades in a referral centre: pregnancy planning and hydroxychloroquine use are associated with improved outcomes.
Rheumatology advances in practiceThe regulatory roles of Beta-2 glycoprotein I (β2GPI) in thrombosis and hemostasis and abnormal disease conditions developed by autoantibodies against β2GPI.
Autoimmunity reviewsThe role of TLR2/MyD88/NF-κB pathway-mediated macrophage M1 polarization in recurrent spontaneous abortion associated with antiphospholipid syndrome.
Human cellAdrenal failure as an antiphospholipid syndrome manifestation: case-based review.
ARP rheumatologyCardiac sarcoidosis with a twist - active and fibrotic sarcoid with antiphospholipid positivity: A case report.
World journal of cardiologyRole of antiphospholipid antibodies in kidney disease: Risk factors, immunopathogenesis, and diagnosis.
World journal of nephrologyAntiphospholipid Antibodies in In vitro Fertilisation: Pathogenesis, Implantation Failure and Emerging Therapeutic Strategies.
The Nigerian postgraduate medical journalThe Epigenetic Angle in the Precision Medicine Era for Blood Disorder Advancements.
Sub-cellular biochemistryAntiphospholipid antibodies induce endothelial procoagulant activity and release of extracellular vesicles independently of a second hit.
Frontiers in immunologyHeterogeneity of antiphospholipid antibody profiles in a clinical cohort and association with distinct clinical features.
RMD openAntiphospholipid Syndrome Coexisting With Evans Syndrome and SCL-70 Antibody Positivity: A Case Report.
Clinical case reportsFactors associated with venous and arterial thrombosis in patients with Systemic Lupus Erythematosus: A systematic review and meta-analysis.
Thrombosis researchPostoperative Bilateral Renal Cortical Necrosis Secondary to Antiphospholipid Syndrome: A Case Report and Literature Review.
Canadian journal of kidney health and diseaseFever of unknown origin, muscle weakness, and an adrenal nodule-the cat we chased like a hare: a case report.
Journal of medical case reportsHemorrhage or thrombosis? Adrenal involvements in a patient with antiphospholipid syndrome.
Rheumatology and immunology researchAssociation between COVID-19 and New-Onset Autoimmune Diseases: Updated Systematic Review and Meta-Analysis of 97 Million Individuals.
Clinical reviews in allergy & immunologyCase Report: The case of atypical OAPS complicated by positive anti-SSA and anti-SSB antibodies.
Frontiers in immunologyMaternal and neonatal outcomes in obstetric antiphospholipid syndrome: a retrospective case-control study.
Frontiers in medicineRecurrent ischaemic strokes as a first presentation of Libman-Sacks endocarditis with an atypically massive mitral vegetation resulting in severe valvular regurgitation: a case report.
European heart journal. Case reportsExploring the association between preeclampsia and antiphospholipid antibodies. A prospective study.
LupusMassive Pulmonary Embolism in the Postpartum Period as the First Manifestation of Antiphospholipid Syndrome: A Case Report.
CureusWhole transcriptome analysis and preliminary construction of ceRNA networks in obstetric antiphospholipid syndrome.
Frontiers in immunologyBrain perfusion scintigraphy with [99mTc]Tc-HMPAO in patients with autoimmune diseases.
Nuclear medicine review. Central & Eastern EuropeNationwide Temporal Trends in Adverse Pregnancy Outcomes and Treatments in Systemic Lupus Erythematosus Pregnancy Over Two Decades in Sweden.
Arthritis & rheumatology (Hoboken, N.J.)Balancing Bleeding and Thrombosis: A Rare Case of Hereditary Hemorrhagic Telangiectasia With Antiphospholipid Syndrome.
CureusNew ACR/EULAR 2023 classification criteria for antiphospholipid syndrome, what should a gynaecologist know in 2025.
Journal of gynecology obstetrics and human reproductionThe role of interferon-mediated suppression of monocyte immunothrombosis in infection susceptibility in systemic lupus erythematosus.
Clinical and experimental immunologyEpidemiological perspectives on SLE and APS in MENA: Burden, barriers, and a path toward improved outcomes.
LupusLibman-Sacks endocarditis of the mitral valve as a first presentation of systemic lupus erythematosus.
Journal of surgical case reportsFibrin clot properties as the missing link between obstetric and thrombotic antiphospholipid syndrome.
Polish archives of internal medicineGenetic and epigenetic insights into systemic lupus erythematosus: linking long non-coding RNA growth arrest-specific transcript 5 and interferon signature.
Journal of rheumatic diseasesAtypical Manifestation of Primary Antiphospholipid Syndrome: Conservative Management of Celiac Trunk Thrombosis Case Report and Literature Review.
Clinical case reportsProthrombotic fibrin clot properties are associated with lower live births rate in women with obstetric antiphospholipid syndrome: a cohort study.
Rheumatology international[Analysis of follow-up and prognosis in pediatric rheumatic diseases associated with pulmonary embolism].
Zhonghua er ke za zhi = Chinese journal of pediatricsAutoimmune Adrenalitis in Systemic Lupus Erythematosus: Identifying a Rare Endocrine Complication.
Cureus[Clinic behavior and therapeutic status of patients with antiphospholipid syndrome].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciencesMolecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole-Blood RNA Transcriptome.
Arthritis & rheumatology (Hoboken, N.J.)Pathophysiology of Primary Budd-Chiari Syndrome: A Narrative Review.
CureusDiffuse alveolar haemorrhage in antiphospholipid syndrome: a French series of 26 patients.
Rheumatology (Oxford, England)Loss of antiphospholipid antibody positivity decreases the risk of recurrent thrombosis in thrombotic antiphospholipid syndrome.
Rheumatology (Oxford, England)Antiphospholipid syndrome presents with aortic thrombosis and central venous catheter-related thrombosis: a case report.
Thrombosis journalTubulointerstitial nephritis and uveitis syndrome: an unexpected diagnosis.
BMJ case reportsImmune-mediated mechanisms and maternal-fetal interface dysfunction in obstetric antiphospholipid syndrome.
Frontiers in immunologyIncidental finding of antiphospholipid antibody syndrome in a patient with Cor Pulmonale: A case report.
JPMA. The Journal of the Pakistan Medical AssociationAcute myocardial infarction and antiphospholipid syndrome: an updated systematic review and meta-analysis.
Annals of medicine and surgery (2012)Severe Aortic Stenosis and Dual Valve Vegetations: An Uncommon Presentation of Primary Antiphospholipid Syndrome.
JACC. Case reportsOsteonecrosis of Femoral Head with Antiphospholipid Syndrome and Acquired Subclinical Hemophilia A.
Clinical laboratoryDifferent phenotypes of severe flares in patients with systemic lupus erythematosus: results of a clustering analysis in a monocentric cohort.
Frontiers in immunologyArtificial intelligence in antiphospholipid syndrome: toward individualized risk prediction.
Research and practice in thrombosis and haemostasisMitral Valve Repair for Mitral Regurgitation Associated with Antiphospholipid Syndrome: A Case Report.
Surgical case reportsHydroxychloroquine does not affect endotheliopathy or coagulopathy biomarkers in COVID-19: longitudinal results from the DisCoVeRy randomized trial.
AngiogenesisSevere Hemoperitoneum From a Ruptured Ovarian Cyst in a Patient with Antiphospholipid Syndrome and Antithrombin III Deficiency: A Case Report.
The American journal of case reportsChallenges in Revascularization in Patients With Systemic Lupus Erythematosus.
JACC. Case reportsObstetric antiphospholipid syndrome: evolving classification and implications for clinical practice and research.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Magnetic Resonance Imaging-Negative Lupus Myelitis: A Narrative Review.
- A Common Missense Variant, W335S, in β2-Glycoprotein I (APOH) is Associated with Increased Autoantibody Levels but Reduced Venous Thromboembolism Risk.
- Hyperbaric oxygen therapy for post-partum bell's palsy associate with anti-phospholipid syndrome: a case report, literature review, and mechanistic insights.
- Perioperative Management of Antithrombotic Therapy in Patients with Thrombotic Antiphospholipid Syndrome.
- Are there disparities in cerebral sinus venous thrombosis between the Arab and Jewish populations in Israel - a multicenter cohort study?
- Clinical Interpretation of Platelet Activation Marker sCLEC-2 in Antiphospholipid Syndrome.
- Contraception in Women With Medical Comorbidities: Clinical Risk Stratification and Individualized Therapeutic Strategies.
- Ultrastructural Injury of Renal Podocytes in Catastrophic Antiphospholipid Syndrome.
- Do ethnoracial differences exist among antiphospholipid antibody-positive patients with no other systemic autoimmune diseases: results from the APS ACTION registry.
- Antiphospholipid Syndrome and Cardiovascular Disease.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:80(Orphanet)
- MONDO:8000010(MONDO)
- GARD:5824(GARD (NIH))
- Busca completa no PubMed(PubMed)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
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