Doença autoimune sistémica rara caracterizada por início agudo de tromboses potencialmente fatais em três ou mais órgãos, simultaneamente ou em menos de uma semana, na presença de anticorpos antifosfolipídicos séricos (como anticoagulante lúpico, anticorpos anticardiolipina e anticorpos anti‐beta‐glicoproteína 1) e com confirmação histopatológica de oclusão de pequenos vasos em pelo menos um órgão afetado. A situação geralmente é precipitada por infeção, trauma ou cirurgia.
Introdução
O que você precisa saber de cara
A Síndrome Antifosfolipíde Catastrófica (CAPS), também conhecida como síndrome de Asherson, é uma doença autoimune rara na qual a coagulação intravascular generalizada causa falência de múltiplos órgãos. A síndrome é causada por anticorpos antifosfolípides que têm como alvo um grupo de proteínas no corpo que estão associadas a fosfolipídios. Esses anticorpos ativam células endoteliais, plaquetas e células imunes, causando, em última análise, uma grande resposta imune inflamatória e coagulação generalizada. A CAPS foi descrita pela primeira vez por Ronald Asherson em 1992. A síndrome exibe microangiopatia trombótica, tromboses de múltiplos órgãos e, em alguns casos, necrose tecidual, sendo considerada uma variante extrema ou catastrófica da síndrome antifosfolípide.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 26 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 52 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Síndrome antifosfolípido catastrófico
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Publicações mais relevantes
Catastrophic Antiphospholipid Syndrome: A Rare but Life-Threatening Thrombotic Storm-A Case Report and Literature Review.
Catastrophic antiphospholipid syndrome (CAPS) is a rare, life-threatening variant of antiphospholipid syndrome (APS) characterized by rapid, widespread thrombosis leading to multiorgan failure. Affecting less than 1% of APS patients, CAPS is associated with a high mortality rate of 30%-50%, necessitating prompt diagnosis and aggressive treatment. The mainstay of management includes anticoagulation, high-dose glucocorticoids, and plasma exchange or intravenous immunoglobulins, with biologic therapies such as rituximab and eculizumab reserved for refractory cases. We report a case of a 60-year-old male with a history of triple-antibody-positive APS complicated by recurrent diffuse alveolar hemorrhage (DAH), adrenal hemorrhage, chronic kidney disease, and superficial vein thrombosis. His condition progressed to CAPS approximately 5 years prior with a course complicated by heparin-induced thrombocytopenia. His condition stabilized with high-dose corticosteroids and rituximab therapy with sustained symptomatic improvement after 10 months of rituximab. This case highlights the complexity of CAPS diagnosis and management, in the context of DAH, emphasizing the importance of early recognition, multidisciplinary care, and individualized treatment strategies. Our patient's prolonged disease stabilization with rituximab underscores its potential role in long-term CAPS management. Further research is needed to refine treatment protocols and improve outcomes for this rare but life-threatening condition.
Imaging features of catastrophic antiphospholipid syndrome : Massive saddle pulmonary embolism with subsequent complete resolution.
Catastrophic antiphospholipid syndrome (CAPS) is a rare thrombotic disorder that can present with distinctive imaging features. Recognition of these imaging patterns is critical for timely diagnosis and management. We report the imaging findings in a 27-year-old woman presenting with acute dyspnea. Computed tomography pulmonary angiography (CTPA) revealed a large saddle embolus at the main pulmonary artery bifurcation with bilateral extension, accompanied by right ventricular dysfunction on echocardiography. The constellation of imaging findings-massive central thrombus burden, right heart dysfunction indices (RV/LV ratio 1.3, TAPSE 13mm), and absence of deep venous thrombosis-prompted consideration of an underlying thrombophilic disorder. Subsequent workup confirmed CAPS with multiorgan involvement. Following treatment with thrombolysis, corticosteroids, and plasmapheresis, follow-up CTPA at three months demonstrated complete thrombus resolution with normalization of cardiac parameters. This case illustrates the characteristic imaging appearance of CAPS-related massive pulmonary embolism and emphasizes the need to recognize high-risk features that suggest underlying systemic thrombophilia. Multimodality imaging is essential for diagnosis, risk stratification, treatment monitoring, and documenting complete resolution.
Catastrophic antiphospholipid syndrome with eosinophilia mimicking hypereosinophilic syndromes with disseminated intravascular coagulation: a case report.
Catastrophic antiphospholipid syndrome is a rare variant of antiphospholipid syndrome where the presence of antiphospholipid antibodies and systemic inflammation leads to the rapid onset of multifocal thrombosis. Eosinophilia is known to accompany conditions such as allergy, parasite infection, malignancy, or autoimmune diseases; however, catastrophic antiphospholipid syndrome with eosinophilia has not been reported and its clinical influence remains unknown. We describe the first case of probable catastrophic antiphospholipid syndrome with eosinophilia, which mimicked eosinophil-associated disorders such as hypereosinophilic syndromes or eosinophilic granulomatosis with polyangiitis with disseminated intravascular coagulation, adding a new aspect of differential diagnosis of eosinophilia. A 46-year-old previously healthy Japanese man presenting with fever, abdominal pain, and skin lesions with pruritus showed marked eosinophilia, thrombocytopenia, and coagulopathy. A dynamic contrast-enhanced computed tomography scan of the abdomen showed some nonenhancing lesions in both lobes of the liver and the portal vein thrombosis. Upper gastrointestinal endoscopy showed gastric erosions, and lower gastrointestinal endoscopy revealed transverse colon and cecum ulcers. Common causes of eosinophilia including allergy, infection, and medication were not detected. He was initially suspected with hypereosinophilic syndromes or vasculitis such as eosinophilic granulomatosis with polyangiitis complicated by disseminated intravascular coagulation, and was treated with prednisone and thrombomodulin from hospital day 4 after bone marrow examination and the biopsies of the skin, stomach, and colon; however, these examinations excluded neoplastic hypereosinophilic syndromes and vasculitis. Later examination revealed positive antiphospholipid antibodies including lupus anticoagulant, anticardiolipin antibodies immunoglobulin G, and anticardiolipin β2-glycoprotein 1 complex antibodies. He was complicated by colonic perforation and bilateral adrenal hemorrhage on day 10. Histopathology of the resected colon and liver biopsy confirmed arterial and venous small-vessel thrombosis and microthrombi, leading to the diagnosis of probable catastrophic antiphospholipid syndrome. He was successfully treated with plasma exchange and rituximab. He has been in remission of catastrophic antiphospholipid syndrome for 4 years, and his antiphospholipid antibodies have been negative post-rituximab treatment. His eosinophil count has been between normal to slightly increased, possibly due to the chronic adrenal insufficiency. Our case shows that eosinophilia can accompany catastrophic antiphospholipid syndrome, and this can mimic eosinophil-associated disorders with disseminated intravascular coagulation. Identifying antiphospholipid antibodies is important for differential diagnosis when treating unexplained eosinophilia, thrombocytopenia, and thrombosis.
Navigating clinical overlap: A case of polyarteritis nodosa in the setting of antiphospholipid syndrome.
Polyarteritis nodosa (PAN) is a systemic necrotising vasculitis of medium-sized arteries, often challenging to differentiate from other autoimmune and thrombotic disorders due to overlapping clinical features. This case-based literature review describes a 56-year-old male with a prior diagnosis of catastrophic antiphospholipid syndrome who presented with digital ischemia, myalgias, and a progressive cutaneous rash. Despite initial treatment with anticoagulation, symptoms persisted, and a skin biopsy ultimately revealed medium-vessel vasculitis consistent with PAN. Muscle biopsy was inconclusive, underscoring the difficulty of diagnosis in the setting of coexisting vasculopathies. This case illustrates the diagnostic complexity at the intersection of inflammatory and thrombotic syndromes and highlights the potential for concurrent or misclassified disease. A review of literature reveals rare but documented associations between PAN and antiphospholipid syndrome, yet no diagnostic tool for differentiation exists. Early recognition and accurate differentiation are critical to optimise outcomes in such overlapping syndromes. Future studies should evaluate a possible differentiation score or explore further diagnostics to help differentiate these inflammatory and thrombotic syndromes to better recognise and treat these conditions.
Catastrophic antiphospholipid syndrome: Clinical characteristics and outcomes in a non-caucasian population - A five-year experience from a single centre.
BackgroundCatastrophic Antiphospholipid Syndrome (CAPS) is a rare but highly severe manifestation of antiphospholipid syndrome (APS), occurring in fewer than 1% of APS patients, but is associated with mortality of around 25-37%, despite treatment. It is characterized by rapid onset of widespread thrombotic events leading to microangiopathy, intravascular thrombosis with multiorgan failure, involving three or more organs within one week. Most published data originate from European or multinational registries like the CAPS Registry. However, data on CAPS in Latin American populations, who may differ in genetic background, socioeconomic status, and healthcare access, remain scarce.MethodsThe objective was to describe the clinical characteristics, treatment strategies, and outcomes of patients diagnosed with CAPS at a tertiary referral center in Mexico City over 5 years. We conducted a retrospective cohort study of patients who fulfilled the CAPS classification criteria between January 2019 and December 2023.ResultsNineteen patients were included (74% female; median age 38.4 years). Six had primary APS, while 11 had concomitant systemic lupus erythematosus (SLE). Based on the 2019 EULAR aPL titers classification, seven patients were classified as low-risk and 12 as high-risk. In 47%, CAPS was the first manifestation of APS. Precipitating factors were identified in 94.7% of cases, most commonly infections and anticoagulant withdrawal. The most frequently affected were the arterial and venous circulation (74% and 68%, respectively), hematologic manifestations (47%), kidneys (42%), lungs (42%), and the heart (32%). Treatment strategies included anticoagulation (84%), corticosteroids (79%), plasma exchange (79%), triple therapy (74%), and, in selected cases, immunosuppressants. Overall mortality was 42%; among survivors, 75% achieved full recovery with no relapses.ConclusionThis study represents one of the largest single-center series of CAPS in a non-Caucasian population. Our findings reveal a predominance of high-risk, secondary APS-mainly SLE-associated-with thrombocytopenia. Nearly half presented with CAPS as the initial APS manifestation. Limited access to full triple therapy significantly impacted mortality, which decreased from 100% with partial therapy to 21% with complete regimens. Early recognition, prompt management, and multidisciplinary care were associated with favourable outcomes, underscoring the need for adaptable therapeutic strategies in resource-limited settings.
Publicações recentes
Ultrastructural Injury of Renal Podocytes in Catastrophic Antiphospholipid Syndrome.
Bartonella henselae infection associated with a multisystemic thrombo-inflammatory syndrome in an immunocompetent adult.
[Management of emergencies in rheumatology].
From hemoptysis to thrombosis: a comprehensive case study of catastrophic antiphospholipid syndrome in a young female.
Severe thrombocytopenia in antiphospholipid syndrome: a retrospective study of 432 patients.
📚 EuropePMC502 artigos no totalmostrando 198
Catastrophic Antiphospholipid Syndrome: A Rare but Life-Threatening Thrombotic Storm-A Case Report and Literature Review.
Case reports in rheumatologyCatastrophic antiphospholipid syndrome in a 39-year-old woman.
CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienneImaging features of catastrophic antiphospholipid syndrome : Massive saddle pulmonary embolism with subsequent complete resolution.
Radiology case reportsCatastrophic antiphospholipid syndrome with eosinophilia mimicking hypereosinophilic syndromes with disseminated intravascular coagulation: a case report.
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Oxford medical case reportsA Near Catastrophe: Antiphospholipid Syndrome and Catastrophic Antiphospholipid Syndrome Complicating Emergency Department Care.
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European journal of rheumatologyCoronavirus disease 2019 and catastrophic antiphospholipid syndrome: Case report.
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SAGE open medical case reportsManagement of Anticoagulation and Antifibrinolytics in Catastrophic Antiphospholipid Syndrome.
Seminars in cardiothoracic and vascular anesthesiaBalloon pulmonary angioplasty under awake veno-arterial extracorporeal membrane oxygenation in a patient with class III obesity with chronic thromboembolic pulmonary hypertension complicated with multiple serious comorbidities.
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Current rheumatology reportsPrimary catastrophic antiphospholipid syndrome in children with midbrain infarction: a case report.
Frontiers in pediatricsTherapeutic plasma exchange in catastrophic antiphospholipid syndrome: a rare case with concomitant systemic lupus erythematosus and infection.
Polish archives of internal medicineCardiac involvement in the catastrophic antiphospholipid syndrome (CAPS): Lessons from the "CAPS registry".
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Rheumatology (Oxford, England)A Case of Catastrophic Antiphospholipid Syndrome with Acute Multiorgan Thrombosis and Concerns for Re-Emergence.
The American journal of case reportsConnective tissue disease as a challenge in heart failure: Three case reports.
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Research and practice in thrombosis and haemostasisCardiac arrest in the setting of probable catastrophic antiphospholipid syndrome in young patient with a history of COVID infection and polyglandular disorder-Case report.
SAGE open medical case reportsUnveiling Complexity: A Case Report of Catastrophic Antiphospholipid Syndrome With Coronary Occlusion and a Concomitant Patent Foramen Ovale Shunt.
CureusComplement biomarkers in the antiphospholipid syndrome - Approaches to quantification and implications for clinical management.
Clinical immunology (Orlando, Fla.)A Rare Case of Refractory Catastrophic Antiphospholipid Syndrome Successfully Treated With Rituximab and Plasma Exchange.
Journal of community hospital internal medicine perspectivesPulmonary involvement in catastrophic antiphospholipid syndrome: A descriptive analysis from the "CAPS Registry".
Seminars in arthritis and rheumatismFrench National Diagnostic and Care Protocol for antiphospholipid syndrome in adults and children.
La Revue de medecine internePerioperative management of patients with antiphospholipid and catastrophic antiphospholipid syndrome undergoing urgent neurosurgery.
Frontiers in pharmacologyCatastrophic Antiphospholipid Syndrome: A Complex Diagnosis in the Setting of Lupus.
CureusAntiphospholipid Syndrome: Thrombotic and Vascular Complications.
Cardiology in reviewCatastrophic Antiphospholipid Syndrome: A Rare Cause of Acute Heart Failure.
CureusAntiphospholipid Syndrome: State of the Art of Clinical Management.
Cardiovascular drugs and therapyA Rare Rheumatologic Case of Catastrophic Antiphospholipid Syndrome.
CureusOligosymptomatic infection by SARS-Cov-2 in catastrophic antiphospholipid syndrome, a singular coincidence: a case report in an Ecuadorian hospital.
Hematology, transfusion and cell therapyPenile Glans Necrosis Associated With Antiphospholipid Syndrome: A Rare Complication.
CureusTherapeutic Plasma Exchange in Catastrophic Antiphospholipid Syndrome (CAPS): A Rare Case Report and Literature Review.
In vivo (Athens, Greece)Choroidal involvement in patients with catastrophic anti-phospholipid syndrome: Two case reports.
European journal of ophthalmologyCatastrophic Antiphospholipid Syndrome and Renal Failure: An Unexpected Recovery After Three Years on Dialysis.
CureusEarly HELLP Syndrome or Catastrophic Antiphospholipid Syndrome? A Diagnostic Dilemma.
CureusCatastrophic antiphospholipid syndrome in Mexico. Literature review.
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Clinical case reportsCatastrophic Antiphospholipid Syndrome: A Case Series.
The Indian journal of radiology & imagingCatastrophic antiphospholipid syndrome immediately after coronary angiography: the unexpected complication.
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosisCatastrophic antiphospholipid syndrome accompanied by complement regulatory gene mutation.
The Turkish journal of pediatricsCatastrophic antiphospholipid syndrome in an immune thrombocytopenia patient treated with avatrombopag.
Research and practice in thrombosis and haemostasisCatastrophic Antiphospholipid Syndrome as a Complication of COVID-19 Infection.
Journal of investigative medicine high impact case reportsAn Unusual Case of Catastrophic Antiphospholipid Syndrome in an Elderly Man.
CureusCatastrophic antiphospholipid syndrome in lupus-associated immune thrombocytopenia treated with eltrombopag A case series and literature review.
MedicineThrombotic storm and cardiovascular manifestations of probable catastrophic antiphospholipid syndrome: the usefulness of multimodal imaging.
European heart journal. Case reportsCorticosteroids, Plasmapheresis, Argatroban, Rituximab, and Sirolimus Provided Clinical Benefit for Catastrophic Antiphospholipid Syndrome in a Patient with a History of Heparin-Induced Thrombocytopenia.
Case reports in rheumatologyPrecipitating factors of catastrophic antiphospholipid syndrome: the role of anticoagulant treatment in a series of 112 patients.
Journal of thrombosis and haemostasis : JTH[Selected severe „haematological“ syndromes in adult intensive care patients].
Vnitrni lekarstviA case report of acute heart failure and cardiogenic shock caused by catastrophic antiphospholipid syndrome and lupus myocarditis.
European heart journal. Case reportsCutaneous Involvement in Catastrophic Antiphospholipid Syndrome in a Multicenter Cohort of 65 Patients.
JAMA dermatologySubacute parkinsonism due to systemic lupus erythematosus and catastrophic antiphospholipid syndrome.
Lancet (London, England)Differentiating and Managing Rare Thrombotic Microangiopathies During Pregnancy and Postpartum.
Obstetrics and gynecologyCatastrophic antiphospholipid syndrome presenting initially as severe abdominal pain.
Polish archives of internal medicineAntiphospholipid Antibody Syndrome-Associated Increased Surface Expression of VLA4 Integrin on Human Monocytes.
BiomedicinesRapidly evolving necrotic skin lesions of the face.
JAAD case reportsEmerging Therapies in Antiphospholipid Syndrome.
Transfusion medicine reviewsDetermination of four homogeneous subgroups of patients with antiphospholipid syndrome: a cluster analysis based on 509 cases.
Rheumatology (Oxford, England)Prevalence, characteristics and outcome of cardiac manifestations in critically-ill antiphospholipid syndrome patients.
Journal of autoimmunity[Heart involvement in systemic lupus erythematosus and antiphospholipid syndrome].
La Revue de medecine interneEarly recognition of catastrophic antiphospholipid syndrome in patients with antiphospholipid syndrome based on a Chinese cohort study.
Clinical and experimental rheumatologySuspected COVID-19 Immunization-Induced Probable Catastrophic Antiphospholipid Syndrome.
CureusNeurologic Manifestations of Catastrophic Antiphospholipid Syndrome.
Current neurology and neuroscience reportsBilateral adrenal hemorrhage: A rare presentation of catastrophic anti-phospholipid syndrome.
The American journal of the medical sciencesUpdate in Hyperferritinemic Syndromes: Recognition and Management - A Scoping Review.
The Brown journal of hospital medicineCatastrophic antiphospholipid syndrome with Epstein-Barr virus-associated hemophagocytosis: A clinicopathological conference.
LupusPontine Infarct as Initial Presentation of Catastrophic Antiphospholipid Syndrome in Systemic Lupus Erythematous.
Acta medica IndonesianaCOVID-19 Vaccines and Autoimmune Hematologic Disorders.
VaccinesSevere Libman-Sacks endocarditis complicating antiphospholipid syndrome: a retrospective analysis of 23 operated cases.
Rheumatology (Oxford, England)The clinical significance of low complement levels in patients with catastrophic antiphospholipid syndrome: A descriptive analysis of 73 patients from the "Catastrophic antiphospholipid syndrome registry".
LupusCardiovascular complications of catastrophic antiphospholipid syndrome: a case report and review of literature.
European heart journal. Case reportsCatastrophic Antiphospholipid Syndrome Presenting as a Stroke in an 11-Year-Old with Lupus.
Case reports in pediatricsCatastrophic Antiphospholipid Syndrome after Orthotopic Liver Transplant.
Case reports in transplantationSmall intestine necrosis in catastrophic antiphospholipid syndrome: A rare and severe case.
LupusAortitis is an under-recognized manifestation of antiphospholipid syndrome: A case report and literature review.
LupusSevere infectious acute respiratory failure mimicking COVID-19 in a healthy adolescent.
Respirology case reportsAll catastrophes are not catastrophic antiphospholipid syndrome.
American journal of hematologyClinical Management of Thrombotic Antiphospholipid Syndrome.
Journal of clinical medicineDigital ischemia as the initial presentation of catastrophic antiphospholipid syndrome.
Reumatologia clinicaEculizumab use in catastrophic antiphospholipid syndrome (CAPS): Descriptive analysis from the "CAPS Registry".
Autoimmunity reviewsCost-effectiveness analysis of treatments for the first episode of catastrophic antiphospholipid syndrome: A study based on the catastrophic antiphospholipid syndrome registry.
LupusRare yet catastrophic presentation of undiagnosed antiphospholipid syndrome.
BMJ case reportsA Middle-Aged Woman Presented with Catastrophic Anti-phospholipid Syndrome in Nephrology Department of BSMMU.
Mymensingh medical journal : MMJCommentary: Managing catastrophic antiphospholipid syndrome-do we have a way out?
JTCVS techniquesCatastrophic antiphospholipid syndrome in the setting of mitral valve repair.
JTCVS techniquesCatastrophic anti-phospholipid syndrome with Libman-Sacks endocarditis following eltrombopag therapy for immune thrombocytopenic purpura: A case report.
LupusCatastrophic antiphospholipid syndrome complicated with essential thrombocythaemia after COVID-19 vaccination: in search of the underlying mechanism.
Rheumatology advances in practiceFerritin - from iron, through inflammation and autoimmunity, to COVID-19.
Journal of autoimmunityCatastrophic antiphospholipid syndrome triggered by mRNA COVID-19 vaccine.
Clinical and experimental rheumatologySecondary vasculopathy due to catastrophic antiphospholipid syndrome.
Hematology, transfusion and cell therapyA Diagnostic Dilemma: Catastrophic or Seronegative Antiphospholipid Syndrome.
CureusConcurrent arterial and venous thrombosis in a patient with catastrophic antiphospholipid syndrome.
Caspian journal of internal medicineReport on effective treatment and genetic predisposition in two children with refractory probable catastrophic antiphospholipid syndrome.
Thrombosis researchCase Report: An Unusual Case of Acute Lower Limb Ischemia as Precursor of the Asherson's Syndrome.
Frontiers in cardiovascular medicineA Case Report of COVID-Associated Catastrophic Antiphospholipid Syndrome Successfully Treated with Eculizumab.
Journal of blood medicineCatastrophic Antiphospholipid Syndrome Associated With Systemic Lupus Erythematosus Flare With Multiorgan Failure: A Chronicle of Cardiogenic Shock, Renal Failure, Vasculitis-Like Lesions, and Disseminated Intravascular Coagulation.
CureusCOVID-19 and adult-onset Still's disease as part of hyperferritinemic syndromes.
Modern rheumatology case reportsCatastrophic Antiphospholipid Syndrome Following Lower Extremity Arterial Bypass Surgery: Case Report and Evidence Review.
Vascular and endovascular surgerySuccessful Treatment of Catastrophic Antiphospholipid Syndrome Using Rituximab: Case Report and Review of the Literature.
Medicina (Kaunas, Lithuania)Case 294: Catastrophic Antiphospholipid Syndrome.
RadiologyPhenytoin Pharmacokinetics During Venoarterial Extracorporeal Membrane Oxygenation and Plasma Exchange.
CureusA Difficult and Rare Case of Warfarin Refractory Antiphospholipid Syndrome Presenting With Catastrophic Antiphospholipid Syndrome Complicated by Gastrointestinal Bleeding.
CureusDisseminated Mycobacterium chelonae infection with Hughes-Stovin syndrome.
Proceedings (Baylor University. Medical Center)[Severe organ manifestations in rheumatic diseases].
Deutsche medizinische Wochenschrift (1946)Complement and the prothrombotic state.
BloodNeovascular Glaucoma as a Presenting Sign of Catastrophic Antiphospholipid Syndrome with a "Catastrophic" Heart Valve Finding.
Case reports in ophthalmologyEarly use of eculizumab for catastrophic antiphospholipid syndrome.
British journal of haematologyCatastrophic antiphospholipid syndrome during pregnancy.
European journal of obstetrics, gynecology, and reproductive biologyPathogenic lipid-binding antiphospholipid antibodies are associated with severity of COVID-19.
Journal of thrombosis and haemostasis : JTHSmall Bowel Necrosis Associated with Catastrophic Antiphospholipid Syndrome: A Case Report.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chiExpert Perspective: Management of Microvascular and Catastrophic Antiphospholipid Syndrome.
Arthritis & rheumatology (Hoboken, N.J.)Characteristics of purified anti-β2GPI IgG N-glycosylation associate with thrombotic, obstetric and catastrophic antiphospholipid syndrome.
Rheumatology (Oxford, England)Ferritin, fever, and frequent visits: Hyperferritinemic syndromes in the emergency department.
The American journal of emergency medicinePrimary Refractory Catastrophic Antiphospholipid Syndrome Masquerading as Buerger's Disease.
CureusErythrocytosis, embolism in a woman with antiphospholipid antibodies: A diagnostic challenge.
Clinical case reportsCatastrophic antiphospholipid syndrome presenting with aortic barrage: case report and review of the literature.
LupusAbnormal immunothrombosis and lupus anticoagulant in a catastrophic COVID-19 recalling Asherson's syndrome.
Journal of thrombosis and thrombolysisCatastrophic Antiphospholipid Syndrome in Immune Thrombocytopenic Purpura - Beyond Tenuous Concomitance!
Indian journal of nephrologyCATASTROPHIC ANTIPHOSPHOLIPID SYNDROME AND POSTERIOR OCULAR INVOLVEMENT: Case Series of 11 Patients and Literature Review.
Retina (Philadelphia, Pa.)Increased levels of ferritin on admission predicts intensive care unit mortality in patients with COVID-19.
Medicina clinica (English ed.)[Spontaneous adrenal hematomas. Retrospective analysis of 20 cases from a tertiary center].
La Revue de medecine interneCatastrophic antiphospholipid syndrome presented as ruptured papillary muscle during puerperium in a patient with systemic lupus erythematosus.
LupusMarkers of complement activation in plasma during quiescent phases in patients with catastrophic antiphospholipid syndrome.
BloodA rare case of catastrophic antiphospholipid syndrome triggered by estrogen-containing oral contraceptives in a patient with double heterozygous factor V Leiden and prothrombin G20210A mutations.
American journal of hematologyImmunosuppressive Treatment in Antiphospholipid Syndrome: Is It Worth It?
Biomedicines[New aspects of therapeutic plasma exchange in critical care medicine].
Deutsche medizinische Wochenschrift (1946)Update on the Use of Intravenous Immunoglobulin in Pregnancy.
NeoReviewsCatastrophic antiphospholipid syndrome post-Epstein-Barr virus infection: a case report.
Hematology, transfusion and cell therapyCOVID-19, Antiphospholipid Antibodies, and Catastrophic Antiphospholipid Syndrome: A Possible Association?
Clinical medicine insights. Arthritis and musculoskeletal disordersCase of catastrophic antiphospholipid syndrome presenting as neuroretinitis and vaso-occlusive retinopathy.
BMC ophthalmologyHematologic Chaos in Lupus Flare: A Case of Fulminant and Simultaneous Antiphospholipid, Anti-ADAMTS13, and Red Blood Cell Autoantibodies.
Case reports in rheumatologySevere mesenteric ischemia with multiple organ failure in a patient previously treated with a humanized monoclonal antibody against programmed death receptor-1 (pembrolizumab), a case of pembrolizumab associated catastrophic antiphospholipid syndrome?
SAGE open medical case reportsSuccessful outcome with eculizumab treatment in a patient with antiphospholipid syndrome presenting with an unusual thrombotic storm.
Journal of thrombosis and thrombolysisHematological Manifestations among Patients with Rheumatic Diseases.
Acta haematologicaConservative Management of Catastrophic Antiphospholipid Syndrome-Related Skin Necrosis: A Case Report.
Advances in skin & wound careCatastrophic Antiphospholipid Syndrome: Skin, Eye and Brain Involvement.
Ocular immunology and inflammationPediatric Catastrophic Antiphospholipid Syndrome Successfully Treated with Eculizumab.
American journal of respiratory and critical care medicineCatastrophic antiphospholipid syndrome associated with systemic lupus erythematosus: a case-based review.
Future cardiologyPediatric catastrophic antiphospholipid syndrome patient evolving to systemic lupus erythematosus.
Lupus16th International Congress on Antiphospholipid Antibodies Task Force Report on Catastrophic Antiphospholipid Syndrome.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Catastrophic Antiphospholipid Syndrome: A Rare but Life-Threatening Thrombotic Storm-A Case Report and Literature Review.
- Imaging features of catastrophic antiphospholipid syndrome : Massive saddle pulmonary embolism with subsequent complete resolution.
- Catastrophic antiphospholipid syndrome with eosinophilia mimicking hypereosinophilic syndromes with disseminated intravascular coagulation: a case report.
- Navigating clinical overlap: A case of polyarteritis nodosa in the setting of antiphospholipid syndrome.
- Catastrophic antiphospholipid syndrome: Clinical characteristics and outcomes in a non-caucasian population - A five-year experience from a single centre.
- Ultrastructural Injury of Renal Podocytes in Catastrophic Antiphospholipid Syndrome.
- Bartonella henselae infection associated with a multisystemic thrombo-inflammatory syndrome in an immunocompetent adult.
- [Management of emergencies in rheumatology].
- From hemoptysis to thrombosis: a comprehensive case study of catastrophic antiphospholipid syndrome in a young female.
- Severe thrombocytopenia in antiphospholipid syndrome: a retrospective study of 432 patients.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:464343(Orphanet)
- MONDO:0018737(MONDO)
- GARD:9820(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q5051580(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
