A shigelose é uma infecção bacteriana que causa disenteria, provocada pela bactéria Shigella. Estas são pequenas bactérias Gram-negativas, muito comuns e que pertencem à família das enterobactérias. Existem quatro espécies: S. dysenteriae, S. flexneri, S. boydii e S. sonnei. Todas elas causam disenteria bacilar e afetam exclusivamente seres humanos.
Introdução
O que você precisa saber de cara
A shigelose é uma infecção bacteriana que causa disenteria, provocada pela bactéria Shigella. Estas são pequenas bactérias Gram-negativas, muito comuns e que pertencem à família das enterobactérias. Existem quatro espécies: S. dysenteriae, S. flexneri, S. boydii e S. sonnei. Todas elas causam disenteria bacilar e afetam exclusivamente seres humanos.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 19 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 46 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Shigelose
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
2 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
64 ensaios clínicos encontrados, 5 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 870
Shigella flexneri and Shigella sonnei among children under five in Kenya's urban informal settlement.
Shigella species are a significant global public health threat with the highest burden of Shigella-associated diarrhoea in children under five years of age, particularly in low- and middle-income countries. Given the high burden of shigellosis in these settings, there is a need for continuous surveillance to identify the prevalent species, risk factors, and determine appropriate intervention strategies. This study aimed to determine the prevalence of Shigella flexneri (S. flexneri) and Shigella sonnei (S. sonnei), assess risk factors and identify Antimicrobial Resistance (AMR) genes present in samples positive for either species among children under five in Mukuru informal settlement. Between August 2023 and November 2024, 386 children presenting with diarrhoea at any of the four selected health facilities in Mukuru were enrolled. Stool samples or rectal swabs were collected and subjected to TaqMan Polymerase Chain Reaction (TAC PCR) for the detection of S. flexneri, S. sonnei and selected AMR genes. Case Report Forms (CRF) and structured questionnaires were used to collect medical history, behavioural and socioeconomic data, respectively. The prevalence of S. flexneri and S. sonnei among the 386 participants was 15.54% (60/386). Positivity for S. flexneri and S. sonnei by age group was highest among children aged 12-23 months (24.84%, 40/161) and lowest among those aged 24-59 months (2.08%, 2/96). S. flexneri was the most prevalent species, with serotypes 2 and X being the most detected. Among the samples positive for S. flexneri and S. sonnei, the mphA gene was detected in 98.33% (59/60), the β-lactamase gene CTX-M1-9 was present in 85% (51/60), and CTX-M2-8-25 was identified in 26.67% (16/60) of samples. Age (aOR = 1.025, 95% CI: 1.003-1.047, P = 0.027) and obtaining vegetables from the market (aOR = 2.737, 95% CI: 1.081-6.930, P = 0.034) were significantly associated with shigellosis. These findings show that shigellosis due to S. flexneri and S. sonnei remains a significant contributor to the burden of diarrheal disease, particularly among young children. The high prevalence of AMR genes, especially mphA and CTX-M β-lactamases, indicates widespread resistance to macrolides and extended-spectrum β-lactams. Addressing this challenge may require a multifaceted approach, including enhanced antimicrobial resistance surveillance, strengthened Water, Sanitation, and Hygiene (WASH) interventions, and the potential deployment of Shigella vaccines among vulnerable populations.
Shigella flexneri 1c bacteremia in a child: a case report.
Shigellosis is a significant public health issue in developing countries, particularly affecting young children under the age of five. While it primarily causes gastrointestinal infections, there are rare complications, such as bacteremia, that mainly occur in young children. We present a case of dysentery caused by Shigella flexneri serotype 1c, followed by bacteremia. A 13-month-old Afghan child presented with fever, dysentery, distended abdomen, mild tenderness, and dehydration. He did not respond to empirical treatment with ceftriaxone. However, he was successfully treated with a combination of gentamicin and ciprofloxacin. This is the first report of a patient in Iran who was positive for S. flexneri serotype 1c and harbored the ipaB, ipaC, ipaD, ipaH, ipgD, virA, and sen virulence factors. This case alerts clinicians to consider the possibility of Shigella bacteremia in young children. Early and accurate diagnosis can improve management and prognosis to reduce the risk of fatality outcomes. Additionally, it emphasizes the need to characterize the role of Shigella spp. virulence genes in causing bacteremia.
Population Pharmacokinetic and Pharmacodynamic Prediction for Tebipenem Pivoxil Treatment of Pediatric Shigellosis.
Increasing antimicrobial resistance poses a serious challenge for the treatment of Shigella infections, and there is an urgent need for alternative antibacterial treatments. We conducted a clinical trial to investigate the efficacy of oral tebipenem pivoxil, compared to intravenous ceftriaxone, in Bangladeshi children with shigellosis. Using demographic data of 2249 Bangladeshi children with suspected shigellosis, population pharmacokinetic (PK) simulations were conducted to simulate tebipenem PK profiles in children with the proposed dosing regimen. Subsequently, the model predictions estimated each virtual participant's fraction of time over the 3-day treatment period during which simulated free tebipenem plasma concentration was above the minimum inhibitory concentration (fT > MIC). Variability associated with the prevalence of different Shigella species in Bangladeshi children and the MIC distributions were incorporated. Shigella treatment effect was assumed for participants that had fT > MIC for at least 40% of the 3-day treatment period (40% fT > MIC). The probability of achieving 40% fT > MIC was 86.4% for 4 mg/kg tebipenem pivoxil three times daily (TID) dosing and 92.4% with 3 mg/kg tebipenem pivoxil four times daily (QID) dosing. Lastly, the probability of tebipenem pivoxil being non-inferior to ceftriaxone, in a clinical trial containing 66 participants per arm, was evaluated for two dosing regimens. Three levels of ceftriaxone resistance were simulated to examine how dynamic ceftriaxone resistance may impact the trial outcome. Our findings suggest that more frequent tebipenem pivoxil dosing may increase the chance of producing treatment effects, contribute valuable insights to inform dosing strategy selection, and demonstrate a workflow that can be adapted to other drugs and diseases.
Shigellosis: antibiotics should be strictly reserved for severe disease and cases at very high risk of onward transmission.
Increasing rates of multidrug-resistant (MDR) and extensively drug-resistant (XDR) Shigella have been detected worldwide. This retrospective review of shigellosis notifications in Southeast Queensland found that XDR Shigella accounted for 48% of notifications. Antimicrobial treatment should be reserved for individuals with severe disease, immunocompromise or high risk of onward transmission.
Genome-wide analysis exploring mechanisms used by Shigella sonnei to survive long-term nutrient starvation.
Shigella is a major cause of severe diarrhea, with Shigella flexneri and Shigella sonnei accounting for over 90% of infections. Progressive economic growth worldwide correlates with the replacement of S. flexneri by S. sonnei as the dominant cause of shigellosis. The basis of the epidemiological shift remains unclear, but it highlights the urgent need for further studies on the increasingly prevalent, but less well-studied, S. sonnei. Here, we investigated whether S. sonnei is better equipped to survive nutrient starvation, a crucial condition for persistence both outside the host and within the colonic lumen. S. sonnei exhibited greater survival under long-term nutrient starvation (LTNS) than S. flexneri, rapidly activating survival mechanisms. We interrogated the genome of S. sonnei using transposon-directed insertion-site sequencing (TraDIS), revealing that metabolic pathways (ATP, nucleotide, and amino acid synthesis) and envelope homeostasis systems (e.g., Tol-Pal complex, Bam complex, peptidoglycan recycling, and RpoE stress response) are conditionally essential for LTNS. TraDIS findings were validated by non-competitive and competitive survival of wild-type and deletion mutant strains. We compared the homology of conditionally essential genes between S. sonnei and S. flexneri to identify genes potentially involved in differential LTNS survival between the species. However, S. sonnei strains in which a single gene was replaced with the S. flexneri allele showed wild-type survival phenotypes. This suggests that the divergent survival of these two species may be more complex than a monogenic difference. Together, these data define the molecular adaptations of starvation resistance in S. sonnei and provide insights into its epidemiological dominance in high-income countries. Understanding why Shigella sonnei has a higher prevalence than Shigella flexneri as a country undergoes economic growth is an important challenge in Shigella research. The investigation of their biological and genetic differences is key to tackling the impact of the disease. We discovered that S. sonnei resists nutrient deprivation better than S. flexneri, suggesting a better adaptation to an extracellular lifestyle and a greater preservation of metabolic capabilities. Using a genome-wide transposon sequencing approach, we uncovered the key pathways behind the survival of S. sonnei facing nutrient starvation, which include ATP, nucleotide, and amino acid synthesis as well as maintenance of cell envelope integrity. Comparative analysis between S. sonnei and S. flexneri did not identify an individual gene responsible for the differing survival and may reflect a multifactorial difference. Our data provide a genome-wide basis for understanding how S. sonnei is adapted to nutrient-deprived settings, which may be advantageous in the gut lumen and for environmental survival, potentially contributing to its dominance in high-income countries.
Publicações recentes
Emergence of Extensively Drug-Resistant Shigellosis - United States, 2011-2023.
Shigellosis awareness and diagnosis in community surveys of men who have sex with men and trans women, San Francisco, California, United States.
Bacteriophage Therapy Against Shigella spp.: A Precision Antimicrobial Strategy.
Population-based incidence and antimicrobial susceptibility patterns of shigellosis among children and adults from rural and urban Kenya, 2010-2019.
Shigellosis: antibiotics should be strictly reserved for severe disease and cases at very high risk of onward transmission.
📚 EuropePMC1.165 artigos no totalmostrando 196
Shigellosis: antibiotics should be strictly reserved for severe disease and cases at very high risk of onward transmission.
Communicable diseases intelligence (2018)Shigella flexneri and Shigella sonnei among children under five in Kenya's urban informal settlement.
Gut pathogensGenome-wide analysis exploring mechanisms used by Shigella sonnei to survive long-term nutrient starvation.
mSystemsInvestigating Autophagy Genes Expression and their Possible Relations with Apoptosis in PBMCs of Patients with Thin Endometrium.
Iranian journal of immunology : IJILooking Beyond the Surface: A Case of Shigella Enterocolitis in a Patient Presenting With Weakness and Substance Use.
CureusOptimizing Shigella isolation: a multi-site evaluation of laboratory culture methods for Shigella detection, speciation, and serotyping with different transport media and sample types in the Enterics for Global Health study.
Journal of clinical microbiologyDevelopment of a Novel Shigella Quadrivalent Conjugate Vaccine Using Shigella O-Polysaccharide and IpaB Carrier Protein.
VaccinesAnti-Shigella activity and killing kinetics of compounds from MMV Pathogen and COVID Boxes: Identifying leads against Shigellosis.
Current research in pharmacology and drug discoveryGenetic Exchanges Shape the Evolutionary Diversification Among Shigella phages.
Journal of molecular evolutionShigella flexneri 1c bacteremia in a child: a case report.
Gut pathogensImmunogenicity evaluation of altSonflex1-2-3 Shigella vaccine across mice, rats, and rabbits to inform human translational insights.
Frontiers in immunologyEpidemiology of Shigella Species in Cameroon: Systematic Review and Meta-Analysis.
Tropical medicine & international health : TM & IHThe natural history of the emergence of sexually transmissible shigellosis.
Microbial genomicsCumulative Incidence of Dysentery Among Under-Five Children in Underprivileged Urban Areas of Bhopal: A One-Year Cohort Study.
Indian journal of community medicine : official publication of Indian Association of Preventive & Social MedicineEmerging Ceftriaxone Resistance in Paediatric Shigella sonnei: A 10-Year Retrospective Study.
Acta paediatrica (Oslo, Norway : 1992)A public resource of 15 genomically characterized representative strains of Shigella sonnei.
Microbial genomicsShigella sonnei and Shigella flexneri: Epidemiology supporting development of cross-protective vaccines.
Human vaccines & immunotherapeuticsPLGA-based nanovaccine delivering chimeric IpaD-StxB protein induces robust immune response against Shigella infection.
Journal of immunological methodsControl of the Food-Borne Pathogen, Shigella flexneri 1457 by Using a Plant Polyphenol Naringenin.
APMIS : acta pathologica, microbiologica, et immunologica ScandinavicaRise of the Resistance: A Case of Resistant Shigellosis in an Immunocompetent Female Patient.
CureusPopulation Pharmacokinetic and Pharmacodynamic Prediction for Tebipenem Pivoxil Treatment of Pediatric Shigellosis.
Clinical and translational scienceImmunoinformatics-based design of a next generation multi-epitope vaccine candidate against Shigella boydii using a hierarchical subtractive proteomics approach.
Scientific reportsEvaluation of the performance and feasibility of RLDT in detecting Shigella in a primary healthcare facility of rural Bangladesh.
medRxiv : the preprint server for health sciencesLithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates.
bioRxiv : the preprint server for biologyEvaluation of cross-functional antibody responses elicited by a four-component GMMA Shigella vaccine.
NPJ vaccinesDefining Severe Shigellosis in the Enterics for Global Health Study: A Comparison of Leading Diarrhea Severity Definitions Among Children With Shigella Diarrhea.
The Journal of infectious diseasesWhole genome analysis of Shigella sp. JZ001: a novel strain isolated from diarrheic suckling mice.
Frontiers in veterinary scienceGut commensal Bifidobacterium longum confers resistance to Salmonella Typhimurium and Shigella flexneri in a Caenorhabditis elegans model.
Microbiology spectrumAsiatic acid, a novel ciprofloxacin adjuvant inhibits Shigella flexneri infection.
Gut microbesCagA-positive H. pylori may protect against disease of the hands, feet, and mouth.
Gut pathogensEvaluating the ciprofloxacin potentiation efficacy of repurposed drug flupentixol through efflux pump inhibition of pathogenic bacteria.
Scientific reportsEnhanced data sharing and coordination to ensure Australia can address the threat of extensively drug-resistant Shigella - a case study for consideration by the Australian Centre for Disease Control.
Communicable diseases intelligence (2018)Evaluating the Adjuvant Therapeutic Effects of Probiotic Strains Lactococcus cremoris and Lacticaseibacillus paracasei on Canine Atopic Dermatitis and Their Impact on the Gut and Skin Microbiome.
Animals : an open access journal from MDPIPrevalence of Shigellosis among household contacts of index cases in the EFGH catchment area, Dhaka, Bangladesh.
PLoS neglected tropical diseasesPhage Henu12-resistant mutant derives fitness trade-offs in Shigella dysenteriae.
Microbiology spectrumGenomic and epidemiological characteristics of Shigella boydii in Australia, 1991-2022.
Pathogens and global healthExtended spectrum β-lactamase and integron genes among Shigella flexneri and Shigella sonnei isolated from children with diarrhea in shiraz, Southwest Iran.
BMC pediatricsThe emergence of sexually transmissible Shigella flexneri serotype 1b between 2019 and 2024 in England: a descriptive epidemiological study.
Microbial genomicsHistorical Advances in Clinical Trial Design and Expanding Representation as the New Frontier for Innovation.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaEnhanced virulence and stress tolerance are signatures of epidemiologically successful Shigella sonnei.
Nature communicationsIs pre-travel advice followed? A study of UK international travellers with gastrointestinal illness and asymptomatic travellers.
Public healthA computational investigation into the role of tRNAs encoded by Shigella phage Sf14.
BMC genomicsAntibodies elicited by altSonflex1-2-3 GMMA vaccine are bactericidal against a panel of drug-resistant Shigella clinical isolates.
Frontiers in immunologyCross-comparison study of three ELISA methodologies to measure Shigella Sonnei O-antigen serum IgG.
mSphereShigellosis in South East Metropolitan Melbourne, 1 January 2022 - 31 March 2023.
Communicable diseases intelligence (2018)Neutralizing antibodies induced by IpaB and IpaC mRNA vaccines inhibit Shigella flexneri invasion.
Microbiology spectrumMacrophages orchestrate elimination of Shigella from the intestinal epithelial cell niche via TLR-induced IL-12 and IFN-γ.
Cell host & microbeAntimicrobial treatment options for extensively drug-resistant (XDR) shigellosis in men who have sex with men.
Sexually transmitted infectionsA "Pandemic-Proof" Methodology for Outbreak Detection Adapted From COVID-19's Impact on Notifications of Infectious Diseases in the Netherlands: Surveillance Study.
JMIR public health and surveillanceCharacterization of Shigella virulence factor intracellular spread A (IcsA, or VirG) functional epitopes against S. flexneri 2a and S. sonnei invasion and adherence.
Applied and environmental microbiologyCinnamomum zeylanicum essential oil inactivates Shigella flexneri by inhibiting biofilm formation, disrupting cell membrane integrity, and suppressing virulence gene expression.
Microbial pathogenesisAn O-Specific Polysaccharide Shigella flexneri 3a Conjugate Vaccine is Immunogenic and Protective against Virulent Keratoconjunctival Challenge in Guinea Pigs.
The American journal of tropical medicine and hygieneAnalyzing Shigella in Wuhan: Serotypes, Antimicrobial Resistance, and Public Health Implications.
Infection and drug resistanceHigh pathogenic potential of Shigella flexneri strains descending from a common ancestor isolated over 34 years in Brazil.
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]A multifunctional anti-O-Antigen human monoclonal antibody protects against Shigella sonnei infection in vivo.
Proceedings of the National Academy of Sciences of the United States of AmericaImpact of the COVID-19 pandemic on five food- and waterborne diseases in six European countries, 2016-21.
European journal of public healthAn in-silico-designed multiepitope vaccine candidate can efficiently protect mice against pathogenic species of Shigella.
Journal of immunological methodsEscherichia coli is implicated in the development and manifestation of host susceptibility to the roundworm Trichostrongylus colubriformis infections in sheep.
Veterinary researchEpidemiologic and Genomic Investigation of Sexually Transmitted Shigella sonnei, England.
Emerging infectious diseasesInhibiting multidrug resistant Shigella flexneri using comparative genomics guided In vitro and In silico screening.
Journal of ethnopharmacologyThe fusion subunit vaccine L-DBF protects aged mice against heterologous lethal Shigella challenge after prior exposure.
Frontiers in immunologyDraft genome sequence of a multidrug-resistant Escherichia coli O13/O129:H11 isolate from imported beef in Saudi Arabia.
Microbiology resource announcementsAccelerated electrochemical antibiotic susceptibility testing using disposable electrodes and Resazurin.
Journal of pharmaceutical and biomedical analysisShigellosis: an update on the disease and analysis of human cases in the Czech Republic, 2018-2023.
Epidemiologie, mikrobiologie, imunologie : casopis Spolecnosti pro epidemiologii a mikrobiologii Ceske lekarske spolecnosti J.E. PurkyneHigh Rates of Bacteremia and Fluoroquinolone Resistance During an Outbreak of Shigellosis Among People Experiencing Homelessness and Opioid Use Disorder in Philadelphia, Pennsylvania.
Open forum infectious diseasesShigella Mutant with Truncated O-Antigen as an Enteric Multi-Pathogen Vaccine Platform.
VaccinesAn Outbreak of Multidrug-Resistant Shigella flexneri Serotype 2a Among People Experiencing Homelessness in Vancouver.
Tropical medicine and infectious diseaseShigella flexneri Bacteremia in an Immunocompetent Woman With Socioeconomic Risk Factors: A Case Report.
CureusMultidrug-resistant Shigella flexneri outbreak affecting humans and non-human primates in New Mexico, USA.
Nature communicationsHost PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation.
PLoS pathogensGut Microbiota Combined With Metabolomics to Reveal the Mechanism of Tang Wang Ming Mu Granule in the Treatment of Diabetic Retinopathy in Mice.
Biomedical chromatography : BMCShigella flexneri Outbreak at a Rehabilitation Center: First Report from Saudi Arabia.
Healthcare (Basel, Switzerland)Spatial visualization provides insight into immune modulation by an L-DBF vaccine formulation against Shigella.
Frontiers in immunologyAssessment of seasonal variations in antibiotic resistance genes and microbial communities in sewage treatment plants for public health monitoring.
Environmental pollution (Barking, Essex : 1987)DNAzyme-based colorimetric biosensor for rapid detection of Shigella flexneri.
Scientific reportsProtein-specific immune response elicited by the Shigella sonnei 1790GAHB GMMA-based candidate vaccine in adults with varying exposure to Shigella.
mSphereInsights from Shigella bacteriophage genomes analysis.
BioinformationEvaluation of extended-spectrum β-lactamase producing bacteria in feces of shelter dogs as a biomarker for altered gut microbial taxa and functional profiles.
Frontiers in microbiologyDevelopment of a Novel mRNA Vaccine Against Shigella Pathotypes Causing Widespread Shigellosis Endemic: An In-Silico Immunoinformatic Approach.
Bioinformatics and biology insightsEpidemiology of Shigella species and serotypes in children: a retrospective substudy of the MAL-ED observational birth cohort study.
The Lancet. MicrobeDynamics of the gut microbiome in subjects challenged with Shigella sonnei 53G in a controlled human infection model.
mSphereEpidemiology of Burkholderia pseudomallei, Streptococcus suis, Salmonella spp., Shigella spp. and Vibrio spp. infections in 111 hospitals in Thailand, 2022.
PLOS global public healthGenetic characterization of extensively drug-resistant blaCTX-M-27Shigella sonnei clusters among men who have sex with men in a region of northern Spain.
International journal of antimicrobial agentsSilent escalation: The journey of Shigella from gut to blood.
Indian journal of medical microbiologyTebipenem pivoxil as an alternative to ceftriaxone for clinically non-responding children with shigellosis: a randomised non-inferiority trial protocol.
BMJ openA case of intercurrent shigellosis and rectal gonorrhea in an acutely unwell febrile returned traveler.
Therapeutic advances in infectious diseaseDiscovering promising drug candidates for Parkinson's disease: integrating miRNA and DEG analysis with molecular dynamics and MMPBSA.
Journal of computer-aided molecular designShigellosis in an Urban Slum in Kenya: Risk Factors and Antimicrobial Resistance.
Open forum infectious diseasesThe rise in domestic shigellosis and the genomic characteristics of Shigella clones linked to men who have sex with men in Taiwan, 2015‒2022.
Microbiology spectrumShigella sonnei and Shigella flexneri infection in Caenorhabditis elegans led to species-specific regulatory responses in the host and pathogen.
Microbial genomicsSafety, Tolerability, and Immunogenicity of the InvaplexAR-DetoxShigella Vaccine Co-Administered with the dmLT Adjuvant in Dutch and Zambian Adults: Study Protocol for a Multi-Center, Randomized, Double-Blind, Placebo-Controlled, Dose-Escalation Phase Ia/b Clinical Trial.
VaccinesModification-specific Proteomic Analysis Reveals Cysteine S-Palmitoylation Involved in Esophageal Cancer Cell Radiation.
ACS omegaMolecular epidemiology of extended-spectrum beta-lactamases and carbapenemases-producing Shigella in Africa: a systematic review and meta-analysis.
BMC infectious diseasesPharmacokinetics of tebipenem pivoxil used in children suffering from shigellosis: a pilot study in Bangladesh.
Scientific reportsSynergistic efficacy of phage Henu10 with antibiotics against Shigella dysenteriae with insight into phage resistance and fitness trade-offs.
Frontiers in cellular and infection microbiologySexually transmitted shigellosis.
Acta dermatovenerologica Alpina, Pannonica, et AdriaticaShared mechanisms of enhanced plasmid maintenance and antibiotic tolerance mediated by the VapBC toxin:antitoxin system.
mBioA newly developed oral infection mouse model of shigellosis for immunogenicity and protective efficacy studies of a candidate vaccine.
Infection and immunityA fractional order model for the transmission dynamics of shigellosis.
HeliyonHigh prevalence of CTX-M-15 producing Shigella spp. isolated from patients with gastroenteritis in Northeast Iran.
Acta microbiologica et immunologica HungaricaResistome phylodynamics of multidrug-resistant Shigella isolated from diarrheal patients.
Microbiology spectrumGenomic Epidemiology of Fluoroquinolone-Resistant Strains of Shigella sonnei and Shigella flexneri in the Iberian Peninsula From 2015 to 2022.
The Journal of infectious diseasesUnveiling the Antibacterial Efficacy of a Benzonitrile Small Molecule, IITR00210, in Shigella Infection.
ACS infectious diseasesIncreased Severity of Multidrug-Resistant Shigella sonnei Infections in People Experiencing Homelessness.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of AmericaGenome and antibiotic resistance characteristics of Shigella clinical isolates in Fujian Province, Southeast China, 2005-2019.
Microbial genomicsImmunization of BALB/c Mice against Shigella sonnei Using a Multiepitope Protein Vaccine through Intranasal and Subcutaneous Administration.
Iranian journal of allergy, asthma, and immunologyUsing demographics of patients to inform treatment of shigellosis in England.
The Lancet. MicrobeAddressing Public Health Risks: Strategies to Combat Infectious Diseases After the August 2024 Floods in Bangladesh.
Journal of preventive medicine and public health = Yebang Uihakhoe chiWhole genome sequencing and antimicrobial resistance among clinical isolates of Shigella sonnei in Addis Ababa, Ethiopia.
PloS oneImpact of an intranasal L-DBF vaccine on the gut microbiota in young and elderly mice.
Gut microbes"Molecular Characterization of Extended Spectrum Beta-Lactamase Resistance in Pediatric Shigella Isolates in Egypt".
Biochemical geneticsSPATEs promote the survival of Shigella to the plasma complement system upon local hemorrhage and bacteremia.
Proceedings of the National Academy of Sciences of the United States of AmericaPrevalence of Shigella species and antimicrobial resistance patterns in Africa: systematic review and meta-analysis.
BMC infectious diseasesEvaluation of a Quadrivalent Shigella flexneri Serotype 2a, 3a, 6, and Shigella sonnei O-Specific Polysaccharide and IpaB MAPS Vaccine.
VaccinesHigh-Throughput Luminescence-Based Serum Bactericidal Assay Optimization and Characterization to Assess Human Sera Functionality Against Multiple Shigella flexneri Serotypes.
International journal of molecular sciencesOuter membrane protein C is a protective and unique vaccine antigen against Shigella flexneri 3a.
Scientific reportsEpidemiology and antimicrobial resistance rates for Shigella species in a resource-rich setting.
Pathology[Phage therapy: where do we stand?].
La Revue du praticien[Risk of acquiring antibiotic-resistant bacteria and travel].
La Revue du praticienImpact of non-pharmaceutical interventions during the COVID-19 pandemic on pathogens transmitted via food in the Netherlands.
Epidemiology and infectionAn RPA-Based CRISPR/Cas12a Assay in Combination with a Lateral Flow Assay for the Rapid Detection of Shigella flexneri in Food Samples.
Foods (Basel, Switzerland)Trends in shigellosis notifications in England, January 2016 to March 2023.
Epidemiology and infectionLimited O-specific polysaccharide (OSP)-specific functional antibody responses in young children with Shigella infection in Bangladesh.
bioRxiv : the preprint server for biologyA multi-epitope protein vaccine encapsulated in alginate nanoparticles as a candidate vaccine against Shigella sonnei.
Scientific reportsSafety and Tolerability of ShigActive™, a Shigella spp. Targeting Bacteriophage Preparation, in a Phase 1 Randomized, Double-Blind, Controlled Clinical Trial.
Antibiotics (Basel, Switzerland)A rhesus macaque intragastric challenge model for evaluating the safety, immunogenicity, and efficacy of live-attenuated Shigella dysenteriae 1 vaccine candidates.
Frontiers in microbiologyCharacterization of azithromycin-resistant Shigella flexneri serotype 2a isolates using whole genome sequencing in Ontario from 2016 to 2018.
Microbiology spectrumDevelopment of a Shigella conjugate vaccine targeting Shigella flexneri 6 that is immunogenic and provides protection against virulent challenge.
VaccineThe Impact of Non-Dysentery Shigella Infection on the Growth and Health of Children over Time (INSIGHT)-A Prospective Case-Control Study Protocol.
MicroorganismsImpact of eugenol on biofilm development in Shigella flexneri 1457: a plant terpenoid based-approach to inhibit food-borne pathogen.
Archives of microbiologyMultidrug-Resistant Shigellosis as a Sexually Transmitted Infection in Advanced HIV: A Case Report.
CureusDeterminants of immune responses predictive of protection against shigellosis in an endemic zone: a systems analysis of antibody profiles and function.
The Lancet. MicrobeThe re-emergence of sexually transmissible multidrug resistant Shigella flexneri 3a, England, United Kingdom.
npj antimicrobials and resistanceAdaptation of a fluoroquinolone-sensitive Shigella sonnei to norfloxacin exposure.
Royal Society open scienceTwenty-five years of sentinel laboratory-based surveillance of shigellosis in a high-income country endemic for the disease, Israel, 1998 to 2022.
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletinMapping the functional B-cell epitopes of Shigella invasion plasmid antigen D (IpaD).
Applied and environmental microbiologyEvaluation of the prophylactic effect of egg yolk antibody (IgY) produced against the recombinant protein containing IpaD, IpaB, StxB, and VirG proteins from Shigella.
Molecular immunologyMultidrug-resistant Shigella flexneri outbreak associated with a high-mortality spillover event into nonhuman primates.
Research squareSupporting health systems and environment in the Democratic Republic of Congo: A call for action.
Health science reportsFirst report of Shigella sonnei carrying a blaCTX-M-15 sexually transmitted among men who have sex with men.
InfectionReported Incidence of Infections Caused by Pathogens Transmitted Commonly Through Food: Impact of Increased Use of Culture-Independent Diagnostic Tests - Foodborne Diseases Active Surveillance Network, 1996-2023.
MMWR. Morbidity and mortality weekly reportCommunicable diseases in Ukraine during the period of 2018-2023: Impact of the COVID-19 pandemic and war.
Travel medicine and infectious diseaseVaccination with a Protective Ipa Protein-Containing Nanoemulsion Differentially Alters the Transcriptomic Profiles of Young and Elderly Mice following Shigella Infection.
VaccinesEnteric Infection-Associated Reactive Arthritis: A Systematic Review and Meta-Analysis.
Journal of clinical medicineEnhancing insights into diseases through horizontal gene transfer event detection from gut microbiome.
Nucleic acids researchProspective Spatiotemporal Cluster Detection Using SaTScan: Tutorial for Designing and Fine-Tuning a System to Detect Reportable Communicable Disease Outbreaks.
JMIR public health and surveillanceA Qualitative Evaluation of the Acceptability of Shigellosis Prevention Recommendations Among Gay, Bisexual, and Other Men Who Have Sex With Men.
Sexually transmitted diseasesUnlocking the potential of Extensin Signal peptide and Elastin-like polypeptide tag fused to Shigella dysenteriae's IpaDSTxB to improve protein expression and purification in Nicotiana tabacum and Medicagosativa.
Protein expression and purificationEmergence of lineage III of Shigella sonnei ST152 belonging to a high-risk clone harboring the blaCTX-M-15 gene in Peru.
Revista Argentina de microbiologiaCinnamaldehyde inhibits the NLRP3 inflammasome by preserving mitochondrial integrity and augmenting autophagy in Shigella sonnei-infected macrophages.
Journal of inflammation (London, England)Identification and analysis of immunoreactive proteins of Shigella flexneri in human sera and stool specimens.
PeerJDesigning a multi-epitope vaccine against Shigella dysenteriae using immuno-informatics approach.
Frontiers in geneticsIdentification of therapeutic drug target of Shigella Flexneri serotype X through subtractive genomic approach and in-silico screening based on drug repurposing.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseasesPolyoxometalate-Polymer Directed Macromolecular Architectonics of Silver Nanoparticles as Effective Antimicrobials.
Chemistry, an Asian journalInvestigation of the vaccine potential of an in silico designed FepA peptide vaccine against Shigella flexneri in mice model.
Vaccine: XOvercoming Microbial Inhibition of S. Sonnei Through the Exploitation of Genomically Predicted Antibiotic Resistance Profiles for the Development of Food Enrichment Media.
Journal of food protectionExtended-Spectrum β-Lactamase Shigella sonnei Cluster Among Men Who Have Sex With Men in Chicago, Illinois, July-October 2022.
The Journal of infectious diseasesStrain-specific Recovery of S. sonnei from Artificially Contaminated Baby Carrots: Enhancing Food-safety Investigations with a Customized Shigella Detection Method Based on Genomically predicted Antibiotic Resistance Traits.
Journal of food protectionMetagenomic dissection of the intestinal microbiome in the giant river prawn Macrobrachium rosenbergii infected with Decapod iridescent virus 1.
Fish & shellfish immunologyPrevalence, associated factors and antimicrobial susceptibility patterns of Salmonella and Shigella species among diarrheic under five children in Sultan Sheik Hassan Yabere referral Hospital, Jigjiga, Eastern Ethiopia.
BMC pediatricsRapid diagnostic tests and loop-mediated isothermal amplification method for the detection of Shigella species: A systematic review and meta-analysis.
Journal of infection and public healthDevelopment of a visual Adhesion/Invasion Inhibition Assay to assess the functionality of Shigella-specific antibodies.
Frontiers in immunologyTesting S. sonnei GMMA with and without Aluminium Salt-Based Adjuvants in Animal Models.
PharmaceuticsShigella Vaccines: The Continuing Unmet Challenge.
International journal of molecular sciencesRisk Factors of Seizure in Childhood Shigellosis.
Iranian journal of child neurologyProlonged Ileus Due to Underlying Shigella Infection After Bilateral Open Inguinal Hernia Repair.
CureusIgG Serum Antibodies to Shigella sonnei Lipopolysaccharide Are Inversely Associated with the Incidence of Culture-Proven S. sonnei Shigellosis in Israeli Children and Adolescents.
VaccinesExploring Natural Immune Responses to Shigella Exposure Using Multiplex Bead Assays on Dried Blood Spots in High-Burden Countries: Protocol From a Multisite Diarrhea Surveillance Study.
Open forum infectious diseasesThe Enterics for Global Health (EFGH) Shigella Surveillance Study in Kenya.
Open forum infectious diseasesThe Enterics for Global Health (EFGH) Shigella Surveillance Study in Peru.
Open forum infectious diseasesMicrobiological Methods Used in the Enterics for Global Health Shigella Surveillance Study.
Open forum infectious diseasesMultidrug-resistant conjugative plasmid carrying mphA confers increased antimicrobial resistance in Shigella.
Scientific reportsModulating the antibacterial effect of the existing antibiotics along with repurposing drug metformin.
Archives of microbiologyThe epidemiological profile of incidence and mortality from epidemics in complex humanitarian emergencies from 1990 to 2022 - A scoping review.
Tropical medicine & international health : TM & IHEpidemiological analysis and prevention strategies in response to a shigellosis cluster outbreak: a retrospective case series in an alternative school in the Republic of Korea, 2023.
Osong public health and research perspectivesPutative correlates of protection against shigellosis assessing immunomarkers across responses to S. sonnei investigational vaccine.
NPJ vaccinesRisk Factors of Developing Postinfectious Irritable Bowel Syndrome in Shigellosis Patients, 5 Years After Hospitalization During the Outbreak.
Open forum infectious diseasesRecent advances in modelling Shigella infection.
Trends in microbiologyBioinformatics Analysis and Experimental Validation of Mitochondrial Autophagy Genes in Knee Osteoarthritis.
International journal of general medicineAge-dependent acquisition of IgG antibodies to Shigella serotypes-a retrospective analysis of seroprevalence in Kenyan children with implications for infant vaccination.
Frontiers in immunologyThe Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology.
Journal of visualized experiments : JoVECollecting a Sexual History During Shigellosis Case Investigations: Nationwide Practices and an Assessment of Data Quality.
Foodborne pathogens and diseaseMolecular Signature of Monocytes Shaped by the Shigella sonnei 1790-Generalized Modules for Membrane Antigens Vaccine.
International journal of molecular sciencesPEtN-Modified O-Antigen Enhances Shigella Pathogenesis by Promoting Epithelial Cell Invasion and Inhibiting Complement Binding.
ACS infectious diseasesMULTISPECIES SHIGELLA FLEXNERI OUTBREAK IN A ZOOLOGICAL COLLECTION COINCIDING WITH A CLUSTER IN THE LOCAL HUMAN POPULATION.
Journal of zoo and wildlife medicine : official publication of the American Association of Zoo VeterinariansIdentification of Renal Transplantation Rejection Biomarkers in Blood Using the Systems Biology Approach.
Iranian biomedical journalShigella as a Cause of Diarrhea Hospitalization in Children Under Five: Evaluation by Conventional and Molecular Methods.
CureusExperimental and pharmacoinformatic approaches unveil the neuropharmacological and analgesic potential of chloroform fraction of Roktoshirinchi (Achyranthes ferruginea Roxb.).
Journal of ethnopharmacologyExpression and purification of TolC as a recombinant protein vaccine against Shigella flexneri and evaluation of immunogenic response in mice.
Microbial pathogenesisComparison of the Intestinal Bacterial Communities between Captive and Semi-Free-Range Red-Crowned Cranes (Grus japonensis) before Reintroduction in Zhalong National Nature Reserve, China.
Animals : an open access journal from MDPICharacterization of genotypes and antimicrobial resistance profiles of clinical isolates of Shigella from patients in the southern region of Iran.
European journal of medical researchCharacterizations of novel broad-spectrum lytic bacteriophages Sfin-2 and Sfin-6 infecting MDR Shigella spp. with their application on raw chicken to reduce the Shigella load.
Frontiers in microbiologyBioactivity and efficacy of a hyperimmune bovine colostrum product- Travelan, against shigellosis in a non-Human primate model (Macaca mulatta).
PloS oneHealthcare providers' knowledge and clinical practice surrounding shigellosis - DocStyles Survey, 2020.
BMC primary careCrystallographic Fragment Screening on the Shigella Type III Secretion System Chaperone IpgC.
ACS omegaRefining Immunogenicity through Intradermal Delivery of Outer Membrane Vesicles against Shigella flexneri in Mice.
International journal of molecular sciencesAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Shigelose.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Shigelose
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Shigella flexneri and Shigella sonnei among children under five in Kenya's urban informal settlement.
- Shigella flexneri 1c bacteremia in a child: a case report.
- Population Pharmacokinetic and Pharmacodynamic Prediction for Tebipenem Pivoxil Treatment of Pediatric Shigellosis.
- Shigellosis: antibiotics should be strictly reserved for severe disease and cases at very high risk of onward transmission.
- Genome-wide analysis exploring mechanisms used by Shigella sonnei to survive long-term nutrient starvation.
- Emergence of Extensively Drug-Resistant Shigellosis - United States, 2011-2023.
- Shigellosis awareness and diagnosis in community surveys of men who have sex with men and trans women, San Francisco, California, United States.
- Bacteriophage Therapy Against Shigella spp.: A Precision Antimicrobial Strategy.
- Population-based incidence and antimicrobial susceptibility patterns of shigellosis among children and adults from rural and urban Kenya, 2010-2019.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:810(Orphanet)
- MONDO:0019345(MONDO)
- GARD:4818(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
- Q327298(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
