Tumor epitelial maligno raro, geralmente grande (maior que 5 cm), que surge das células corticais adrenais. Os sintomas geralmente estão relacionados à produção excessiva de hormônios e incluem a síndrome de Cushing e o virilismo nas mulheres. Os locais comuns de metástase incluem fígado, pulmão, ossos e linfonodos retroperitoneais. Procedimentos radiológicos avançados permitiram a detecção de pequenos tumores, resultando na melhoria da sobrevida em 5 anos.
Introdução
O que você precisa saber de cara
Tumor epitelial maligno raro, geralmente grande (maior que 5 cm), que surge das células corticais adrenais. Os sintomas geralmente estão relacionados à produção excessiva de hormônios e incluem a síndrome de Cushing e o virilismo nas mulheres. Os locais comuns de metástase incluem fígado, pulmão, ossos e linfonodos retroperitoneais. Procedimentos radiológicos avançados permitiram a detecção de pequenos tumores, resultando na melhoria da sobrevida em 5 anos.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 20 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 30 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
6 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells
Cell membrane
Carney complex 1
CNC is a multiple neoplasia syndrome characterized by spotty skin pigmentation, cardiac and other myxomas, endocrine tumors, and psammomatous melanotic schwannomas.
E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby restricting the size of the intestinal stem cell zone (PubMed:22575959). Along with RSPO2 and RNF43, constitutes a master s
Cell membrane
Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein
CytoplasmNucleus
Key downstream component of the canonical Wnt signaling pathway (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:18957423, PubMed:21262353, PubMed:22155184, PubMed:22647378, PubMed:22699938). In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome (PubMed:17524503, PubMed:18077326, PubMed:18086858, PubMed:189574
CytoplasmNucleusCytoplasm, cytoskeletonCell junction, adherens junctionCell junctionCell membraneCytoplasm, cytoskeleton, microtubule organizing center, centrosomeCytoplasm, cytoskeleton, spindle poleSynapseCytoplasm, cytoskeleton, cilium basal body
Colorectal cancer
A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history.
Multifunctional transcription factor that induces cell cycle arrest, DNA repair or apoptosis upon binding to its target DNA sequence (PubMed:11025664, PubMed:12524540, PubMed:12810724, PubMed:15186775, PubMed:15340061, PubMed:17317671, PubMed:17349958, PubMed:19556538, PubMed:20673990, PubMed:20959462, PubMed:22726440, PubMed:24051492, PubMed:24652652, PubMed:35618207, PubMed:36634798, PubMed:38653238, PubMed:9840937). Acts as a tumor suppressor in many tumor types; induces growth arrest or apop
CytoplasmNucleusNucleus, PML bodyEndoplasmic reticulumMitochondrion matrixCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-de
Nucleus, nucleolusNucleus, nucleoplasmNucleusChromosome, telomereCytoplasmNucleus, PML body
Medicamentos aprovados (FDA)
1 medicamento encontrado nos registros da FDA americana.
Variantes genéticas (ClinVar)
2,622 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
84 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Carcinoma adrenocortical
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
17 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
111 ensaios clínicos encontrados, 24 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 2.326
Factors Associated With Rare Pediatric Cancer Trial Enrollment: A Report From the Children's Oncology Group Rare Tumors Committee.
Over 90% of US children with cancer are treated at Children's Oncology Group (COG) centers, which seek to maximize enrollment in therapeutic and biobanking studies. Rare cancers have demonstrated lower than expected COG enrollment. We evaluated trends in COG rare cancer enrollment compared to US incidence from Surveillance, Epidemiology, and End Results (SEER) registries, examining the impact of COG therapeutic trials and Project:EveryChild, a cancer biobank/registry. COG and SEER data from 2002 to 2020 were queried for US patients younger than 18 years old with adrenocortical carcinoma (ACC), nasopharyngeal carcinoma (NPC), retinoblastoma (RB), thyroid carcinoma, and melanoma. We compared demographic data between COG and SEER, extrapolating incidence for each cancer to analyze trends in COG enrollment. Patient characteristics, including age, sex, and race, were similar between COG (n = 2184) and SEER (n = 5514). COG enrollment for rare cancers remained low (11%). Initiating Project:EveryChild did not increase enrollment (12% pre- vs. 8% post-Project:EveryChild; p < 0.01). For cancers with available therapeutic trials (ACC, NPC, and RB), COG enrollment was higher during trial accrual (40%) than when no trial was open (12%; p < 0.01). Patient geography and income did not appear as barriers to COG enrollment. Although children with rare cancers enrolled in COG studies reflect the US population, enrollment in the COG registry/biospecimen repository continues to be limited in the absence of therapeutic trials, impacting data and biospecimens available to inform therapeutic trial development. Expansion of therapeutic trials or free molecular testing through the Molecular Characterization Initiative may increase data and biospecimens for these rare cancers.
A Case of Pediatric Adrenocortical Carcinoma With McCune-Albright Syndrome Masquerading as Spontaneously Regressing Neuroblastoma.
Quality of life questionnaire development and validation for adrenocortical carcinoma patients.
ACC patients' quality of life may be impacted by symptoms related to cancer or treatments, as well as emotional, spiritual, existential, social, economic, and sexual aspects. The aim was the development and psychometric validation of a new instrument (QoLACC) for measuring Patient Reported Outcome in patients with ACC. The study was conducted from October 2024 to January 2025 at the Oncology Unit of Brescia's ASST. Fifteen patients and 15 physicians graded the comprehensibility/difficulty and relevance of the items of QoLACC whereas 37 consecutive patients assessed psychometric validity. Comprehensibility, difficulty and clinical relevance of the items to include in the QoLACC questionnaire were assessed by selected ACC patients and clinicians. Validated scales were co-administered to the developed QoLACC questionnaire to assess physical and psychological symptoms, and the test-retest reliability and construct validity psychometric validation were performed. The QoLACC items showed excellent content validity [0.93-1.00] and acceptable to excellent comprehensibility [0.80-1.00] and difficulty [0.80-1.00], with minor exceptions. Item analysis showed good discriminant capability and response variability. The total questionnaire has good reliability (the intraclass correlation coefficient (ICC) was 0.870 [95% CI: 0.734-0.937]) and construct validity proved by the moderate to strong correlations [0.39-0.62] between the QoLACC and the EORTC item 29 and item 30, the QoLACC financial section and the COST (0.47), and the QoLACC spiritual section and the JSWBS (0.60). We defined and validated the Italian questionnaire aiming to explore ACC patients' quality of life, to help the Health Care Professionals to manage and support these patients.
Adrenocortical Carcinoma: From genomics to patients.
Adrenocortical carcinoma (ACC) is a rare malignancy with limited therapeutic options and poor prognosis in advanced stages. Clinico-pathological markers, such as Ki67 and ENSAT stage remain insufficient to fully predict recurrence or treatment response, highlighting the need for molecular characterization.Molecular classification: Omic approaches, including transcriptomics, DNA methylation and chromosomal alteration profiling have consistently identified two distinct ACC subtypes "C1A" and "C1B". C1A tumors, overexpressing proliferation genes, are associated to poorer outcomes. C1B tumors however, are characterized by their immune signature and are of better prognosis. Single-cell analyses have helped understanding the mechanisms underlying these differences, hinting at a central role of intratumoral steroid differentiation in shaping the immune microenvironment.Clinical and therapeutic perspectives: Transcriptome sequencing from paraffin-embedded samples are bringing molecular classification closer to routine care, with ongoing prospective trials evaluating its feasability. Genomic classification represents a major step in ACC management and understanding, offering improved prognostic stratification and orienting future therapeutic strategies.
ACR Appropriateness Criteria® Staging and Follow-Up of Adrenal Cancer.
Primary adrenal gland malignancies include adrenocortical carcinoma (ACC) and pheochromocytoma. For initial staging and restaging or surveillance of known or suspected ACC, MRI of the abdomen and pelvis without and with contrast, CT of the abdomen and pelvis with contrast, CT of the chest with contrast, and fluorine-18-2-fluoro-2-deoxy-D-glucose (FDG)-PET/CT, or FDG-PET/MRI are recommended to assess for local extent and distant metastases or to evaluate for recurrence. For initial staging and restaging or surveillance of known or suspected pheochromocytoma, MRI of the abdomen and pelvis without and with contrast, CT of the abdomen and pelvis with contrast, CT of the chest with contrast, DOTATATE PET/CT, or DOTATATE PET/MRI are recommended to assess local extent and distant metastases or to evaluate for recurrence. Meta-iodobenzylguanidine (MIBG) scan whole body with single-photon emission CT (SPECT) or SPECT/CT area of interest is an acceptable alternative for initial staging of known or suspected pheochromocytoma, in particular to determine eligibility for I-131 MIBG therapy. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision process support the systematic analysis of the medical literature from peer reviewed journals. Established methodology principles such as Grading of Recommendations Assessment, Development, and Evaluation or GRADE are adapted to evaluate the evidence. The RAND/UCLA Appropriateness Method User Manual provides the methodology to determine the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where peer reviewed literature is lacking or equivocal, experts may be the primary evidentiary source available to formulate a recommendation.
Publicações recentes
Case Report: Peritoneal disease from adrenal cortical carcinoma with hepatic metastases managed with cytoreductive surgery and multiple HIPEC sessions, resulting in survival beyond 13 years.
Clinicopathologic Determinants of Overall Survival in Adrenocortical Carcinoma: A SEER-Based Population Study.
Pan-cancer analysis reveals FOLH1 as a prognostic biomarker and immune modulator in human tumors.
Management of Adrenal Incidentalomas: A Survey of Physicians from the Middle East and Africa.
📖 RevisãoNormalization of Potassium Despite 11-Deoxycorticosterone Rise During Etomidate Therapy in Adrenocortical Carcinoma.
📚 EuropePMC2.452 artigos no totalmostrando 199
Quality of life questionnaire development and validation for adrenocortical carcinoma patients.
European journal of endocrinologyAdrenocortical Carcinoma: From genomics to patients.
Annales d'endocrinologieACR Appropriateness Criteria® Staging and Follow-Up of Adrenal Cancer.
Journal of the American College of Radiology : JACROncocytic adrenocortical carcinoma: A case report.
Urology case reportsAdrenocortical Carcinoma as a Manifestation of Birt-Hogg Dubé Syndrome.
Endocrine-related cancerSurgical Resection of Abdominal Solid Organ Tumors With Inferior Vena Cava Extension: A Single-Center Experience With Long-Term Follow-Up.
CureusA Case of Pediatric Adrenocortical Carcinoma With McCune-Albright Syndrome Masquerading as Spontaneously Regressing Neuroblastoma.
Pediatric blood & cancerInternational Real-world study on osilodrostat efficacy and safety in adrenal Cushing syndrome.
The Journal of clinical endocrinology and metabolismHepatic embolization for Cushing syndrome from metastatic tumors: a single-center case series.
Journal of the Endocrine SocietyIn-depth Genetic and Molecular Characterization of Unilateral Coexisting Adrenal Cortical Adenoma and Carcinoma in the Context of MEN1 Syndrome.
Endocrine pathologyRare Association Between Neurofibromatosis Type 1 and Adrenocortical Carcinoma.
Clinical case reportsAdrenocortical carcinoma presenting with extensive striae: A case report and literature review.
Indian journal of cancerAdult-type epithelial neoplasms in children and adolescents-A retrospective analysis on a subgroup of very rare tumors.
Indian journal of cancerClinical predictors of outcome in advanced adrenocortical carcinoma: a multicenter international ENSAT study.
European journal of endocrinologyPrognostic, chemotherapy and immunotherapy roles of GPR37/GPR37L1 in pan-cancer.
MedicineNatural history of large adrenal tumors.
Frontiers in endocrinologyPrognostic role of pretreatment [18F]FDG PET/CT in patients affected by adrenocortical carcinoma and treated with chemotherapy.
European journal of nuclear medicine and molecular imagingTime trends in incidence, treatment and survival of patients with adrenocortical carcinoma, a nationwide study.
The Journal of clinical endocrinology and metabolismPrevalence of venous extension in malignant adrenal neoplasia: beyond primary tumors and identification of a novel imaging sign.
European radiologyExpression of YME1 Like 1 ATPase Increases With the Stage of Adrenocortical Carcinoma Tissue and Is Associated With Poor Patient Prognosis.
Anticancer researchTargeting ER stress in adrenocortical carcinoma: Celastrol as a novel therapeutic candidate.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieExceptional Response to a Single Dose of Pembrolizumab as Salvage Therapy for Metastatic Adrenocortical Carcinoma.
JCEM case reportsHistopathological and Molecular Characteristics of Pediatric Adrenocortical Tumors: where Do we Stand?
Endocrine pathologyDigital vs conventional glycemic monitoring in rare endocrine cancers: comparison of effectiveness during chemotherapy.
Endocrine connectionsA case of immune thrombocytopenia aggravated by therapy for hypercortisolism in adrenocortical carcinoma.
Therapeutic advances in endocrinology and metabolismClinical Application of Steroid Profiles and Their Interpretation in Adrenal Disorders.
Diagnostics (Basel, Switzerland)Three cases of pediatric adrenocortical carcinoma with intermediate malignant potential: a case report with literature review.
AME case reportsPreclinical evaluation of progesterone combined with EDP-M scheme in 2D and 3D models of adrenocortical carcinoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieEndocrine Hypertension: The Role of Imaging in Diagnosis and Management.
The British journal of radiologyMismatch repair deficiency and microsatellite instability in adrenocortical carcinoma.
ESMO openLipid synthesis seems to drive proliferation in Men1 mouse adrenals and human adrenocortical cell lines.
Endocrine-related cancerReliability of CT attenuation value for adrenal masses.
Endocrine connections[Sarcomatoid variant of adrenocortical carcinoma].
MedicinaMassive non-functioning Adrenocortical carcinoma presenting as acute abdomen without rupture: A case report.
Urology case reportsHepcidin concentration and effect on iron homeostasis in patients with adrenocortical carcinoma and benign adrenal lesions - a pilot study.
Endocrine[Adrenocortical carcinoma (ACC): current surgical treatment strategies].
Chirurgie (Heidelberg, Germany)Characterization of Unilateral Adrenal Incidentalomas: Hormonal Analysis, Computed Tomography, and Magnetic Resonance Imaging Correlation.
CureusOver-expression of Anillin Actin Binding Protein in Adrenocortical Carcinoma Tissues Is Associated With Poorer Prognosis of Patients.
Anticancer researchPan-Cancer Landscape of CDK1 Uncovers Its Potential Prognostic Significance and Therapeutic Targeting in Adrenocortical Carcinoma.
Anticancer researchA nonfunctional adrenal incidentaloma revealed by intestinal obstruction: metastatic adrenocortical carcinoma diagnosed by surgery.
Endocrinology, diabetes & metabolism case reportsAssessment of Adrenal Cortical Neoplasms for the GU Pathologist.
Advances in anatomic pathologyDeath receptor 3: A paradoxical biomarker and therapeutic target in pan-cancer.
Critical reviews in oncology/hematologyIs adrenal adenoma to carcinoma transformation possible? - Illustrative cases and literature review.
The Journal of clinical endocrinology and metabolismMachine Learning Approach for Differentiation of Pheochromocytoma from Adrenocortical Cancer and Non-Functioning Adrenal Adenomas.
Life (Basel, Switzerland)Perspectives on Adrenal Tumor Surgery.
Medicina (Kaunas, Lithuania)Steroid Phenotype Stratification Reveals Distinct HLA Expression Signatures in Adrenocortical Carcinoma.
CancersAdrenocortical Carcinoma With Right Atrial Extension in a Three-Year-Old Child: A Case Report.
CureusAndrogen production in adrenocortical H295R cells is regulated by thyroid hormone T3 without reciprocal thyroid axis modulation in pediatric CAH.
The Journal of steroid biochemistry and molecular biologySerum steroid profiling by LC-MS/MS in distinguishing adrenocortical carcinoma from other indeterminate adrenal masses.
The Journal of steroid biochemistry and molecular biologyTargeting matrix metalloproteinase-14 disrupts DNA repair and reduces viability in adrenocortical carcinoma.
bioRxiv : the preprint server for biologyEstablishment of a patient-derived adrenocortical carcinoma 3D tumor construct platform for evaluation of therapeutic strategies.
bioRxiv : the preprint server for biologyMachine Learning-Driven Identification and In Vitro Validation of the APOBEC3B-ANLN Regulatory Axis in Adrenocortical Carcinoma.
EndocrineMinimally Invasive Tubular Transpedicular Partial Corpectomy and Percutaneous Segmental Posterior Fixation With a Combined Titanium and Carbon Fiber Construct: 2-Dimensional Operative Video.
Operative neurosurgery (Hagerstown, Md.)Adrenal tumors in the elderly.
Endocrine-related cancerChemo-immunotherapy with cisplatin and nivolumab as second-line approach in metastatic adrenocortical carcinoma.
European journal of endocrinologyA novel 2D and 3D model for primary adrenocortical carcinoma of advanced and metastasized stage co-secreting cortisol, aldosterone, testosterone, 18-oxocortisol and 18-hydroxycortisol.
Endocrine-related cancerPrevalence and clinical characteristics of Lynch syndrome-associated adrenocortical carcinoma.
Endocrine-related cancerNeutrophil-to-lymphocyte ratio as a prognostic predictor in adrenocortical carcinoma: a retrospective cohort study stratified by cortisol secretion status.
Translational cancer researchPsychosocial burden in adrenocortical carcinoma patients.
European journal of endocrinologyMitotane dosage, plasma levels, and anthropometric measurements in pediatric adrenocortical carcinoma.
Endocrine oncology (Bristol, England)Systemic immune-inflammation index as an independent predictor of malignancy in 4-6 cm adrenal incidentalomas.
Actas urologicas espanolasInteraction between ENPP1 and homologous recombination deficiency defines distinct pan-cancer signatures: A retrospective observational study.
MedicineThe role of PCMT1 in prognosis tumor immune microenvironment and therapeutic responses across cancers.
Discover oncologyBioinformatics Analysis Reveals that Minichromosome Maintenance 10 Replication Initiation Factor Is a Possible Prognostic Marker for Patients With Adrenocortical Carcinoma.
Cancer diagnosis & prognosisAdrenocortical Carcinoma and Inferior Vena Cava Thrombosis: Diagnosis and Perioperative Management.
CureusAdrenocortical Mitochondria-Associated Membranes: Isolation, Characterization, and Lipidoproteomic Response to Mitotane.
Journal of the Endocrine SocietyLong-Term Transcriptomic Reprogramming in Peripheral Blood Mononuclear Cells of Severe COVID-19 Survivors Reveals Pro-Oncogenic Signatures and Cancer-Associated Hub Genes.
VirusesThe Intricate Puzzle of Adrenocortical Tumors: Revisitation of Two Old Cases of Virilizing Adrenocortical Neoplasia with Contradictory Diagnostic and Histopathological Findings and Opposite Conclusions.
Life (Basel, Switzerland)Metabolic and Cardiac Complications in a Case of Adrenal Carcinoma.
EJIFCCFactors Associated With Rare Pediatric Cancer Trial Enrollment: A Report From the Children's Oncology Group Rare Tumors Committee.
Pediatric blood & cancerDescription of six cases of melanoma in 512 patients with germline pathogenic variants in the TP53 gene.
Familial cancerMitotane-Induced Hypothyroidism and Dyslipidemia in Adrenocortical Carcinoma: Sex Differences and Novel Evidence from a Thyroid Cell Model.
Current oncology (Toronto, Ont.)Precision Care for Hereditary Urologic Cancers: Genetic Testing, Counseling, Surveillance, and Therapeutic Implications.
Current oncology (Toronto, Ont.)ASO Visual Abstract: Surgical Management and Outcomes in Pediatric Adrenocortical Carcinoma: A Pediatric Surgical Oncology Research Collaborative Study.
Annals of surgical oncologyA genome-wide RNAi screen for novel CIN genes using human artificial chromosome.
PNAS nexusNew Diagnosis of Adrenocortical Carcinoma with Stroke Workup.
Case reports in neurologyOutcome and Toxicity Profile of Stereotactic Body Radiation Therapy for Adrenal Tumours in Dogs.
Veterinary and comparative oncologyVLDL: The key factors influencing the distribution of mitotane in patients with adrenocortical carcinoma.
Journal of pharmaceutical analysisImpact of Adjuvant Radiotherapy and Mitotane on Survival in Localized Adrenocortical Carcinoma: A Retrospective Cohort Study.
International journal of urology : official journal of the Japanese Urological AssociationExploring the causal relationship between matrix metalloproteinases and adrenocortical carcinoma: A Mendelian randomization study.
MedicineRising Incidence of Neuroendocrine Neoplasms in Northern Switzerland-Data From the Cancer Registry.
Journal of the Endocrine SocietyBilateral adrenal tumors presenting with Cushing syndrome in the setting of horseshoe kidney: surgical and urological considerations (case report).
The Pan African medical journalCharacteristic of Aldosterone-Producing adrenocortical carcinoma: review of the literature.
Medical oncology (Northwood, London, England)Intratumoral Microbiota Correlates with AP-2 Expression: A Pan-Cancer Map with Cohort-Specific Prognostic and Molecular Footprints.
International journal of molecular sciencesAdrenal-adipose tissue crosstalk in health and disease.
European journal of endocrinologyDiagnostic accuracy of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in the differential diagnosis of adrenocortical carcinoma: a retrospective study.
Translational andrology and urologyA quantitative, broad-panel LC-MS/MS method for the analysis of intact steroid conjugates: A novel approach to steroid profiling for biomarker research in corticoid-dependent diseases.
Journal of pharmaceutical and biomedical analysisCharacterization of p53 p.T253I as a pathogenic mutation underlying Li-Fraumeni Syndrome.
PloS onePediatric Adrenocortical Carcinoma Presenting With Virilization: A Case of a Low-Grade Tumor in a Young Child.
CureusProlonged Mitotane Administration in Metastatic Adrenocortical Carcinoma With Over a Decade of Survival: A Case Series.
Case reports in endocrinologyUnveiling PAK4 as a Key Biomarker in Adrenocortical Carcinoma: Insights from Bioinformatics and Experimental Evidence.
Archivos espanoles de urologiaMitigating subtherapeutic cabozantinib exposure after prior mitotane therapy in adrenocortical carcinoma: Pharmacological boosting with cobicistat.
British journal of clinical pharmacologyPostoperative Hemodynamic Instability Following Adrenalectomy for Presumed Adrenocortical Carcinoma: Anesthetic Implications of a Rare Cavernous Hemangioma.
CureusRare but not forgotten: Therapeutic advancements for rare childhood cancers.
Molecular therapy. OncologyPosterior retroperitoneoscopic adrenalectomy (PRA) in adrenocortical carcinoma (ACC).
Langenbeck's archives of surgery(Non)canonical Wnt signaling, cytoarchitecture and stemness: new insights from primary nonmetastatic, primary metastatic, regional and distant metastatic models of adrenocortical carcinoma.
Experimental & molecular medicineA comprehensive pan-cancer analysis of the prognostic role and immunotherapy efficacy evaluation of Glyoxalase 1.
Discover oncologyThe Utility of Cabozantinib in the Therapy of Endocrine Tumours.
Endocrine pathologyThe RAB27A effector SYTL5 regulates mitophagy and mitochondrial metabolism.
eLifeOligometastatic adrenocortical carcinoma: definition and treatment.
Current opinion in oncologyOncocytic Adrenocortical Carcinoma in an Infant: Clinical Findings and Imaging Features.
Clinical nuclear medicineSynergistic Inhibition of PI3K and HSP90 Enhanced Antitumorigenic Efficacy in Adrenocortical Carcinoma.
Research squareCorrigendum to "FGF/FGFR inhibitors downmodulate c-Myc oncoprotein and hamper the growth of adrenocortical carcinoma" [Biomed. Pharmacother. 192 (2025) 118677].
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapiePrimary cholangiocarcinoma of the adrenal gland: a surgical and diagnostic challenge - a case report.
BMC urologyMolecular landscape and biomarker discovery in adrenocortical carcinoma: An integrative review of bioinformatics and translational insights.
Pathology, research and practiceComparative Proteomic Profiling of Adrenocortical Neoplasia Using Mass Spectrometry.
Journal of proteome researchSurgical Management and Outcomes in Pediatric Adrenocortical Carcinoma: A Pediatric Surgical Oncology Research Collaborative Study.
Annals of surgical oncologyReal-world osilodrostat effectiveness and safety in non-pituitary Cushing syndrome.
The Journal of clinical endocrinology and metabolismPrevalence of Malignancy Among Incidental Indeterminate Adrenal Nodules on Contrast-Enhanced CT in Patients Without Known Cancer: A Multiinstitutional Study.
AJR. American journal of roentgenologyGlutamine antagonism suppresses tumor growth in adrenocortical carcinoma through inhibition of de novo nucleotide biosynthesis.
bioRxiv : the preprint server for biologyInnovative molecular targets for combatting metastasis in adrenocortical carcinoma.
Frontiers in endocrinologyPotential endogenous lipid ligands for the nuclear receptor transcription factor Steroidogenic Factor-1.
Advances in biological regulationThe Cytoskeleton in Adrenal Physiology and Tumours: Functional Roles and Emerging Molecular Targets.
International journal of molecular sciencesContemporary Approaches to Adrenocortical Carcinoma.
Hematology/oncology clinics of North AmericaThe role of 18F-FDG PET/CT in adrenocortical carcinoma: a systematic review.
Endocrine-related cancerPublisher Correction: Adrenocortical carcinoma survival gene HMMR was identified as being targeted by fluorouracil and epirubicin using a gene coexpression network-based drug repositioning strategy.
Scientific reportsA comprehensive approach to the CT detection and evaluation of large adrenal masses part 2: malignant adrenal lesions and future directions.
Abdominal radiology (New York)[Advances in the diagnosis and treatment of adrenal cortex surgical diseases].
Zhonghua wai ke za zhi [Chinese journal of surgery]Adrenal hemorrhage: diagnostics, management, and treatment. Review and clinical update.
Wideochirurgia i inne techniki maloinwazyjne = Videosurgery and other miniinvasive techniquesIdentification of EFNA3 as candidate prognosis marker and potential therapeutic target for adrenocortical carcinoma.
Oncology lettersComprehensive Analysis Identifies Tumor Mutation Burden-associated Genes ASPM and KIF11 as Novel Biomarkers for Adrenocortical Carcinoma.
Current cancer drug targetsAgouti-related peptide: a promising prognostic biomarker in adrenocortical carcinoma. Results from a large single-centre cross-sectional analysis.
European journal of endocrinologySynergistic dual oncogenic role of CKS2 and ACAT2: Enhanced regulatory coherence and biomarker potential in adrenocortical carcinoma.
Cancer geneticsMultivisceral Resection for Suspected Adrenocortical Carcinoma.
Journal of clinical medicinePhase 2 Study of Monotherapy with Pembrolizumab for Advanced Adrenocortical Carcinoma.
Journal of immunotherapy and precision oncologyBilateral and recurrent adrenocortical carcinoma in MEN1: a case report and review of the literature.
Endocrine oncology (Bristol, England)Determination of phytonutrients, antioxidant properties and in vitro effect of the microgreen Trigonella foenum-graecum L. on H295R carcinoma cells.
3 BiotechA novel therapeutic approach to adrenocortical carcinoma repurposing fingolimod to target sphingolipid metabolism in metastatic disease.
SurgeryFeminizing Adrenocortical Carcinoma in Men: A Rare Cause of Persistent Gynecomastia and a Contemporary Literature Review.
Epidemiologia (Basel, Switzerland)Role of Palliative Bronchial Stenting in Endobronchial Metastasis: An Atypical Case of Metastatic Adrenocortical Carcinoma in a Young Patient.
Clinical case reportsFGF/FGFR inhibitors downmodulates c-Myc oncoprotein and hampers the growth of adrenocortical carcinoma.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieCase Report: Adrenal angiomatoid fibrous histiocytoma misdiagnosed as pheochromocytoma.
Frontiers in oncologySorCS3 suppresses adrenocortical carcinoma progression by enhancing IGF2R-mediated endocytic trafficking and signaling attenuation.
Journal of translational medicineGermline targeted next-generation sequencing in patients with adrenal incidentalomas.
Frontiers in endocrinologyPrimary adrenal lymphoma and its mimics: clinico-radiological differential diagnosis.
Frontiers in endocrinologyPreclinical evaluation of the antitumoral efficacy of Wee1 inhibitor AZD1775 in adrenocortical carcinoma.
Pharmacological researchDemographics, Clinical Profiles, and Outcomes of Patients With Adrenal Disorders in a Tertiary Care Center: A Retrospective Study.
CureusAutomated Microfluidic Platform for Single Spheroid Culture and Extracellular Vesicle Isolation: Application to Spheroid Transcriptomic Profiling.
Small (Weinheim an der Bergstrasse, Germany)Investigation of DNA Damage Response Genes Validates the Role of DNA Repair in Pediatric Cancer Risk and Identifies SMARCAL1 as a Novel Osteosarcoma Predisposition Gene.
Journal of clinical oncology : official journal of the American Society of Clinical OncologyThe choice of adjuvant radiotherapy in adrenocortical carcinoma patients after radical adrenalectomy: a population-based analysis.
Discover oncologyDiagnosis and grading of adrenal cortical carcinoma.
Virchows Archiv : an international journal of pathologyImpact of steroid differentiation on tumor microenvironment revealed by single-nucleus atlas of adrenal tumors.
Nature communicationsRapidly Progressive Metastatic Adrenocortical Carcinoma With Oncocytic Features in a Young Male: A Case Report.
CureusRobotic adrenalectomy: a comprehensive review of perioperative outcomes, comparative efficacy, and technological advancements.
Journal of robotic surgeryMulti-omics-based molecular classification of adrenocortical carcinoma predicts response to immunotherapy and targeted treatments.
Discover oncologyIncidence and risk factors of venous thromboembolism in an adrenocortical carcinoma patient cohort.
Endocrine connectionsSurgical management of metastatic adrenocortical carcinoma: Is there a role for multivisceral resection?
SurgeryCase Report: Trilostane therapy in a dog with recurrent adrenocortical carcinoma producing an array of steroid hormones.
Frontiers in veterinary scienceAbdominal distention and lethargy in a 6-year-old spayed female ferret.
Journal of the American Veterinary Medical AssociationOncocytic Carcinoma: A Rare Hormone-Producing Tumor.
CureusMulti-modal characterization of metabolic and immune gene clusters in adrenocortical carcinoma treatment.
NPJ precision oncologyEducational Point-of-Care Ultrasound Discovers Adrenal Cortical Carcinoma, a Case Report: Clinical Implications and Review of the Literature.
HCA healthcare journal of medicineCabozantinib plus Atezolizumab in Advanced, Progressive Endocrine Malignancies: A Multicohort, Basket, Phase II Trial (CABATEN/GETNE-T1914).
Clinical cancer research : an official journal of the American Association for Cancer ResearchEfficacy of systemic therapy in metastatic adrenocortical carcinoma: a meta-analysis of prospective clinical trials.
Endocrine oncology (Bristol, England)SLC16A3 (MCT4) expression in tumor immunity and Metabolism: Insights from pan-cancer analysis.
Biochemistry and biophysics reportsIron Oxide Nanoparticle Uptake, Toxicity, and Steroidogenesis in Adrenocortical Carcinoma Cells Using a Multicellular in vitro Model.
International journal of nanomedicineGiant non-functioning adrenocortical carcinoma: a case report and literature review.
Chinese clinical oncologyNon-functional oncocytic adrenocortical carcinoma: Case report with clinicopathologic and surgical correlation.
Urology case reportsFrontiers in Systemic Therapy for Unresectable or Metastatic Adrenocortical Carcinoma: Harnessing Novel Therapeutic Approaches.
Clinical Medicine Insights. OncologyMitotane-Induced Endocrine Alterations in Children with Adrenocortical Carcinoma: Clinical Implications from a 20-Year Retrospective Study.
Children (Basel, Switzerland)Tailored surgery for large adrenal tumors: the minimally invasive to open (hybrid) approach.
Updates in surgeryThe UALCAN and GEPIA Analyses of the TCGA Database Show a Strong Association Between Increased Expression of Stathmin 1 in Adrenocortical Carcinoma Tissues and Patient Survival.
Anticancer researchExploring DNA topoisomerase II alpha in adrenocortical carcinoma through multi-omics analysis: a potential biomarker and therapeutic target.
Acta biochimica et biophysica SinicaThe value of CT texture analysis in predicting mitotic activity and morphological variants of adrenocortical carcinoma.
Frontiers in radiologyClinicopathological spectrum of adrenal tumors: a retrospective study from a Romanian tertiary referral center.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieClinical spectrum, imaging characteristics, and treatment outcomes of pediatric adrenocortical tumors: a 24-year experience from Western India.
Journal of pediatric endocrinology & metabolism : JPEMA standardized surgical approach to multifocal locoregionally recurrent left-sided adrenocortical carcinoma.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyIn-frame germline TP53 variant impairs p53 oligomerization and predisposes to cancer.
Scientific reportsA Case of Myxoid Adrenocortical Carcinoma With 1p Deletion Identified by Whole Exome Sequencing.
Pathology internationalEvaluating the diagnostic utility of [⁶⁸Ga]Ga-Pentixafor in solid tumors: a systematic review.
Annals of nuclear medicineA nationwide study evaluating indications and outcomes for adrenalectomy in children in the Netherlands.
SurgeryA rare pediatric case of Li-Fraumeni syndrome presenting with virilization symptoms and dual primary malignancies on magnetic resonance imaging and [18F]-fluorodeoxyglucose positron emission tomography/computed tomography.
Pediatric radiologyTranscriptomic validation and clinical translation of CCDC78 as a prognostic biomarker in colorectal cancer.
American journal of cancer researchExternal validation of the S-GRAS score for predicting recurrence in patients with adrenocortical carcinoma: implications for adjuvant mitotane therapy.
European journal of endocrinologyEfficacy and Safety of Radiotherapy and Systemic Treatments in Adrenocortical Carcinoma: Systematic Review and Meta-Analysis.
The Journal of clinical endocrinology and metabolismAdverse events related to mitotane during treatment of adrenocortical carcinoma.
MedicinaAdrenal Incidentaloma Masquerading as Malignancy: A Rare Case of Ganglioneuroma with Nodal Metastasis.
Case reports in oncologyMetastatic Pheochromocytoma in a Patient With Li-Fraumeni Syndrome.
JCEM case reportsDifferentiating between adrenocortical carcinoma and pheochromocytoma by a CT-based radiomics model: a multicenter retrospective study.
BMC medical imagingExtraordinary Response to Mitotane Monotherapy in Advanced Aggressive Adrenocortical Carcinoma.
JCEM case reportsHyperandrogenism-induced Athletic Excellence in a Young Patient with Adrenocortical Carcinoma: 10 Years of Remission.
JCEM case reportsManagement of cushing's syndrome in patients with adrenocortical cancer: state of the art and future perspectives.
Reviews in endocrine & metabolic disordersMachine learning-based classification of adrenal tumors using clinical, hormonal, and body composition data.
European journal of endocrinologyPrognostic Factors Among Patients with Non-metastatic Adrenocortical Carcinoma.
International journal of endocrinology and metabolismPrognostic factors and treatment outcomes in patients with adrenal cortical carcinoma: A registry-based study.
MedicineKi-67 as a Predictor of Metastasis in Adrenocortical Carcinoma: Artificial Intelligence Insights from Retrospective Imaging Data.
Journal of clinical medicineComprehensive analysis of an ATF/CREB family-based signature with regard to prognosis and immune feature in adrenocortical carcinoma: a cohort study.
International journal of surgery (London, England)β-catenin functions as a molecular adapter for disordered cBAF interactions.
Molecular cellHigh expression of EFNA3 in adrenocortical carcinoma and its association with prognosis.
International journal of clinical pharmacology and therapeuticsCell division cycle 20 promotes tumor progression and predicts poor clinical outcome in childhood and adult adrenocortical carcinoma.
Journal of clinical & translational endocrinologyReport of a rare case of childhood adrenocortical carcinoma and literature review.
Urology case reportsAdrenocortical carcinoma survival gene HMMR was identified as being targeted by fluorouracil and epirubicin using a gene coexpression network-based drug repositioning strategy.
Scientific reportsEmerging treatment options for adrenocortical carcinoma.
Current opinion in endocrinology, diabetes, and obesityDefactinib in Combination with Mitotane Can Be an Effective Treatment in Human Adrenocortical Carcinoma.
International journal of molecular sciencesBimodal Genomic Approach Predicting Semaphorin 7A (SEMA7A) as Prognostic Biomarker in Adrenocortical Carcinoma.
CancersAdrenocortical organoids: A promising tool for modelling human physiology and translational research.
Presse medicale (Paris, France : 1983)The management of adrenocortical carcinoma in the era of precision medicine.
Critical reviews in oncology/hematologyTherapeutic frontiers in adrenocortical carcinoma: from standards to innovation.
Medical oncology (Northwood, London, England)An Excellent Clinical and Radiological Response Pattern to Pembrolizumab in a Patient With Metastatic Adrenocortical Carcinoma and Lynch Syndrome.
IJU case reportsAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Carcinoma adrenocortical.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Carcinoma adrenocortical
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Factors Associated With Rare Pediatric Cancer Trial Enrollment: A Report From the Children's Oncology Group Rare Tumors Committee.
- A Case of Pediatric Adrenocortical Carcinoma With McCune-Albright Syndrome Masquerading as Spontaneously Regressing Neuroblastoma.
- Quality of life questionnaire development and validation for adrenocortical carcinoma patients.
- Adrenocortical Carcinoma: From genomics to patients.
- ACR Appropriateness Criteria® Staging and Follow-Up of Adrenal Cancer.
- Case Report: Peritoneal disease from adrenal cortical carcinoma with hepatic metastases managed with cytoreductive surgery and multiple HIPEC sessions, resulting in survival beyond 13 years.
- Clinicopathologic Determinants of Overall Survival in Adrenocortical Carcinoma: A SEER-Based Population Study.
- Pan-cancer analysis reveals FOLH1 as a prognostic biomarker and immune modulator in human tumors.
- Management of Adrenal Incidentalomas: A Survey of Physicians from the Middle East and Africa.
- Normalization of Potassium Despite 11-Deoxycorticosterone Rise During Etomidate Therapy in Adrenocortical Carcinoma.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:1501(Orphanet)
- MONDO:0006639(MONDO)
- GARD:558(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q918285(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
