Mal de Desembarque (MdD) é uma condição rara caracterizada por uma sensação persistente de movimento — como se estivesse balançando, flutuando, caindo ou boiando — que surge após um período de exposição a movimentos passivos. Isso geralmente ocorre depois de uma viagem de navio, ou outros tipos de transporte aquático, trem, carro ou avião, e, menos frequentemente, após outros movimentos (como dormir em uma cama d'água). Em alguns pacientes, o início pode ser espontâneo. Os sintomas começam logo após o estímulo, persistem por 6 meses a anos e podem estar associados a ansiedade, cansaço e dificuldade de concentração ou raciocínio. Os sintomas frequentemente pioram em ambientes fechados ou ao tentar ficar parado (como sentado, deitado ou em pé, sem se mover), e melhoram quando a pessoa está em movimento passivo, como em um carro, avião ou trem andando.
Introdução
O que você precisa saber de cara
Mal de Desembarque (MdD) é uma condição rara caracterizada por uma sensação persistente de movimento — como se estivesse balançando, flutuando, caindo ou boiando — que surge após um período de exposição a movimentos passivos. Isso geralmente ocorre depois de uma viagem de navio, ou outros tipos de transporte aquático, trem, carro ou avião, e, menos frequentemente, após outros movimentos (como dormir em uma cama d'água). Em alguns pacientes, o início pode ser espontâneo. Os sintomas começam logo após o estímulo, persistem por 6 meses a anos e podem estar associados a ansiedade, cansaço e dificuldade de concentração ou raciocínio. Os sintomas frequentemente pioram em ambientes fechados ou ao tentar ficar parado (como sentado, deitado ou em pé, sem se mover), e melhoram quando a pessoa está em movimento passivo, como em um carro, avião ou trem andando.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 10 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 17 características clínicas mais associadas, ordenadas por frequência.
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
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Publicações mais relevantes
Update on functional vestibular and gait disorders.
Three functional neurological disorders are encountered in neuro-otologic practice, persistent postural-perceptual dizziness (PPPD), which is the commonest cause of chronic vestibular and balance symptoms, mal de debarquement (MdDS), a rarer but potentially debilitating disorder, and functional gait disorder, an often overlooked but treatable condition. Recent investigations of PPPD suggested that there may be subtypes or subthreshold variants that merit further investigation. Studies of pathological mechanisms continue to offer new insights into the complex processes that initiate and sustain the disorder, which will require nuanced models to bring together disparate findings. Evidence continues to accumulate in support of vestibulo-ocular reflex readaptation therapy for MdDS, with pilot studies offering refinements and possible alternatives. Functional gait disorder is one of the commonest manifestations of functional neurological disorder, often presenting with other functional neurological symptoms including PPPD. Specialized methods of physical and occupational therapy continue to mature. Optimal outcomes may require short and focused periods of intensive treatment. Evolving theories and continuing emergence of new data are beginning to make functional vestibular and gait disorders a manageable part of neuro-otologic practice.
Corrigendum to "Mal de Debarquement Syndrome in Children: A Case Series" The Journal of Pediatrics 259 (2023):113435.
Motion Exposure, Cognitive Impairment, and Risk Factors for Mal de Débarquement Syndrome.
Determine whether shipboard motion variability relates to simulator‑sickness symptoms, Mal de Débarquement syndrome (MdDS) features, and cognition, and whether migraine or motion‑sickness history modify these vestibular effects. Prospective observational cohort. USNS Mercy (T‑AH 19) during Pacific Partnership 2024. 38 Active‑Duty personnel were tested at baseline (land), after California-Hawaii (CA-HI; rougher), and after Chuuk-Hawaii (CHUUK-HI; calmer). A centrally mounted, inertial measurement unit (IMU) yielded per‑minute standard deviation of linear‑acceleration magnitude (IMU SD). Simulator Sickness Questionnaire (SSQ); MdDS calculator mapped to Bárány criteria; Rey-Osterrieth Complex Figure (ROCF); Symbol Digit Modalities Test (SDMT); Stroop Test; linear mixed-effects model using voyage leg and IMU SD as predictors of symptom outcomes and adjusted for migraine and motion‑sickness history. IMU SD was higher on CA-HI. SSQ totals were higher on CA-HI and increased with IMU SD. MdDS criteria counts, and cases were similar between legs; Migraine Disability Assessment Score (MIDAS) was positively associated with MdDS criterion burden, but not with SSQ. ROCF showed slower copy/recall and lower recall accuracy on CA-HI; SDMT and Stroop errors were largely unchanged. There were no statistical differences based on migraine or motion‑sickness history, but analyses were limited by small subgroup sizes. Rougher sea states (greater IMU variability) were linked to higher acute symptom burden and specific visuospatial memory impairments. The incidence of persistent MdDS did not differ by leg. IMU‑informed monitoring with brief, targeted cognitive tests may support future planning and post‑voyage screening to identify at-risk individuals.
Potential lesson from a model-based exploration on treatment effect heterogeneity of mal de débarquement syndrome.
A central vestibular neural mechanism known as velocity storage may be inappropriately conditioned in mal de débarquement syndrome (MdDS), a rare chronic vestibular disorder with a continuous false sensation of self-motion described as non-spinning vertigo. Visual-vestibular therapy approaches designed to recondition the three-dimensional properties of velocity storage have yielded much clinical success, but not without limitations. An alternative therapeutic approach, designed to attenuate the contribution of malfunctioning velocity storage in higher-order neural processing, has also yielded positive results, but at a lower success rate. We sought a possible explanation for the latter shortcoming using a mathematical model. The three-dimensional orientation properties of velocity storage can be modeled as a dynamical system using a 3 × 3 system matrix. For normal upright, the system matrix is diagonal, with its eigenvectors aligning with the head-fixed roll, pitch, and yaw axes, and the yaw eigenvector with gravity. A pull sensation of MdDS has been expressed with a system matrix with off-diagonal elements representing cross-axis coupling and interpreted as a misalignment between the yaw eigenvector and the head vertical. We manipulated the velocity storage's yaw time constant and output weight. The model predicted that attenuating the velocity storage contribution could exaggerate the pull sensation. The present model-based exploration points to a possible weakness in the MdDS treatment approach focused on velocity storage attenuation, while likely beneficial otherwise. When a pulling sensation is present, the treatment protocol may need to be supplemented with another approach that specifically counters this problem, such as optokinetic stimulation.
Dizziness: When Is It Migraine, and When Is It Not?
Dizziness is a frequent neurologic symptom in patients with headache, which overlaps with many etiologies beyond vestibular migraine. This review aims to help neurologists distinguish when dizziness is due to vestibular migraine (VM) versus other vestibular syndromes. VM is now recognized as the most common cause of spontaneous episodic vertigo, with expanding diagnostic criteria, new pathophysiological insights involving CGRP, and emerging treatment strategies including anti-CGRP therapies. It overlaps with benign paroxysmal positional vertigo (BPPV), Meniere's disease, persistent postural-perceptual dizziness (PPPD), and cerebrovascular events. Novel tools such as the Vestibular Migraine Patient Assessment Tool and Handicap Inventory (VM-PATHI) and frameworks like Timing, Triggers And Targeted Examination (TiTrATE) enhance diagnostic accuracy and patient outcomes. Differentiating VM from other causes of dizziness relies on a detailed clinical history, neurological examination, and increasingly, awareness of VM's protean features and comorbidities. Recognition is essential as treatments can differ significantly across etiologies. Future research should target biomarkers, subtypes and comparative treatment trials for VM and its mimics.
Publicações recentes
Motion Exposure, Cognitive Impairment, and Risk Factors for Mal de Débarquement Syndrome.
Corrigendum to "Mal de Debarquement Syndrome in Children: A Case Series" The Journal of Pediatrics 259 (2023):113435.
[Mal de Débarquement Syndrome - a poorly understood and rare condition in clinical practice].
Update on functional vestibular and gait disorders.
Potential lesson from a model-based exploration on treatment effect heterogeneity of mal de débarquement syndrome.
📚 EuropePMC110 artigos no totalmostrando 103
Motion Exposure, Cognitive Impairment, and Risk Factors for Mal de Débarquement Syndrome.
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck SurgeryCorrigendum to "Mal de Debarquement Syndrome in Children: A Case Series" The Journal of Pediatrics 259 (2023):113435.
The Journal of pediatrics[Mal de Débarquement Syndrome - a poorly understood and rare condition in clinical practice].
Zhurnal nevrologii i psikhiatrii imeni S.S. KorsakovaUpdate on functional vestibular and gait disorders.
Current opinion in neurologyPotential lesson from a model-based exploration on treatment effect heterogeneity of mal de débarquement syndrome.
Frontiers in neurologyDizziness: When Is It Migraine, and When Is It Not?
Current neurology and neuroscience reportsGalvanic vestibular stimulation for Mal de Debarquement syndrome: a pilot study on therapeutic potential.
Experimental brain researchInvestigation of Mal de Debarquement Syndrome in Pilots Based on Flight Time.
Journal of audiology & otologyTranscranial magnetic stimulation use with chronic vestibular disorders: A scoping review.
Journal of vestibular research : equilibrium & orientationThe utility of artificial vestibular stimulation in decoding the pathophysiology of mal de débarquement syndrome.
Frontiers in neurologyPersistent Oscillating Vertigo From Extracranial Venous Compression.
Otology & neurotology openPersistent Motion Sensation: A Case Report of Mal De Débarquement Syndrome in a Long-Term Boat Dweller.
CureusEar, nose and throat disorders and international travel.
Tropical diseases, travel medicine and vaccinesMal de Debarquement Syndrome: A Case Presentation of a Vestibular Enigma.
CureusMal De Debarquement Syndrome: An Often Unrecognized and Unreported Condition.
CureusOn labyrinthine function loss, motion sickness immunity, and velocity storage.
Frontiers in neurologyVirtual reality application matches the most established treatment for Mal de Debarquement Syndrome: A non-inferiority, randomized, open clinical trial.
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeuticsBeyond Vertigo: Vestibular, Aural, and Perceptual Symptoms in Vestibular Migraine.
Current pain and headache reportsGuideline for standardized approach in the treatment of the Mal de Debarquement syndrome.
Frontiers in neurologySymptom reduction in mal de débarquement syndrome with attenuation of the velocity storage contribution in the central vestibular pathways.
Frontiers in rehabilitation sciencesAssessing the synergistic effectiveness of intermittent theta burst stimulation and the vestibular ocular reflex rehabilitation protocol in the treatment of Mal de Debarquement Syndrome: a randomised controlled trial.
Journal of neurologySuspected Mal de Debarquement Syndrome: A Case Report Highlighting the Difficulty in Diagnosis and Management.
Military medicineWhat's in a Name? Chronic Vestibular Migraine or Persistent Postural Perceptual Dizziness?
Brain sciencesThe Hidden Enemy: Mal de Débarquement Syndrome and Its Impact on Military Operations.
Military medicineQuestioning the Impact of Vestibular Rehabilitation in Mal de Debarquement Syndrome.
Audiology & neuro-otologyCLINICAL AND OBJECTIVE TEST CHARACTERISTICS OF VESTIBULAR MIGRAINE: IMPLICATIONS FOR DIAGNOSIS AND MANAGEMENT.
Georgian medical newsMigraine management for the otolaryngologist.
Laryngoscope investigative otolaryngologyChronic Multicanalicular BPPV as a Possible Cause of mal de Débarquement Syndrome.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyManagement of Migraine-Associated Vestibulocochlear Disorders.
Audiology researchMal de Débarquement Syndrome Complicated by Psychiatric Comorbidities: Response to Maruta et al.
The primary care companion for CNS disordersCreating Informed Interest in Mal De Débarquement Syndrome.
The primary care companion for CNS disordersMal de Débarquement Syndrome in Children: A Case Series.
The Journal of pediatricsLasting alteration of spatial orientation induced by passive motion in rabbits and its possible relevance to mal de débarquement syndrome.
Frontiers in neurologyTreatment Options in Mal de Débarquement Syndrome: A Scoping Review.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyNovel ways to modulate the vestibular system: Magnetic vestibular stimulation, deep brain stimulation and transcranial magnetic stimulation / transcranial direct current stimulation.
Journal of the neurological sciencesMal de Debarquement Syndrome Complicated by Psychiatric Comorbidities.
The primary care companion for CNS disordersMal de Debarquement Syndrome explained by a vestibulo-cerebellar oscillator.
Mathematical medicine and biology : a journal of the IMATreatment of Mal de Debarquement Syndrome in an Audiology-Vestibular Clinic.
Journal of the American Academy of AudiologyVisual disorders and mal de debarquement syndrome: a potential comorbidity questionnaire-based study.
Future science OASeasickness among Icelandic seamen.
PloS oneSelf-motion perception without sensory motion.
Experimental brain researchTreatment of Gravitational Pulling Sensation in Patients With Mal de Debarquement Syndrome (MdDS): A Model-Based Approach.
Frontiers in integrative neuroscienceMal de Debarquement Syndrome: Treatment in an Audiology Balance Center.
Journal of the American Academy of AudiologyDouble-blind randomized N-of-1 trial of transcranial alternating current stimulation for mal de débarquement syndrome.
PloS oneCharacterization of Balance Problems and Rehabilitation Needs of Patients with Ménière's Disease.
Audiology researchRemotely Monitored Home-Based Neuromodulation With Transcranial Alternating Current Stimulation (tACS) for Mal de Débarquement Syndrome.
Frontiers in neurologyInfluence of sex hormones on vestibular disorders.
Current opinion in neurologyBrain network effects by continuous theta burst stimulation in mal de débarquement syndrome: simultaneous EEG and fMRI study.
Journal of neural engineeringPsychological assessment of individuals with Mal de Débarquement Syndrome.
Journal of neurologyCurrent and Emerging Medical Therapies for Dizziness.
Otolaryngologic clinics of North AmericaClinical, oculographic, and vestibular test characteristics of vestibular migraine.
Cephalalgia : an international journal of headacheTranscranial Alternating Current Stimulation Reduces Network Hypersynchrony and Persistent Vertigo.
Neuromodulation : journal of the International Neuromodulation SocietyNeuroimaging Markers of Mal de Débarquement Syndrome.
Frontiers in neurologyAn uncommon cause of headache and dizziness after cruise travel: case report of Mal De Debarquement syndrome.
Journal of osteopathic medicineGathering your 'sea legs': Extended durations in an offshore environment increases postural sway excursions.
Gait & postureIn Reference to The Interconnections of Mal de Débarquement Syndrome and Vestibular Migraine.
The LaryngoscopeTreatment of Mal de Debarquement Syndrome in a Computer-Assisted Rehabilitation Environment.
Military medicineThe Scientific Contributions of Bernard Cohen (1929-2019).
Frontiers in neurologyMal de Debarquement Syndrome: A Matter of Loops?
Frontiers in neurologyThe Interconnections of Mal de Débarquement Syndrome and Vestibular Migraine.
The LaryngoscopeReadaptation Treatment of Mal de Debarquement Syndrome With a Virtual Reality App: A Pilot Study.
Frontiers in neurologyMal de débarquement syndrome diagnostic criteria: Consensus document of the Classification Committee of the Bárány Society.
Journal of vestibular research : equilibrium & orientationNeural Correlates of Transient Mal de Debarquement Syndrome: Activation of Prefrontal and Deactivation of Cerebellar Networks Correlate With Neuropsychological Assessment.
Frontiers in neurologyTranscranial Magnetic Stimulation as Treatment for Mal de Debarquement Syndrome: Case Report and Literature Review.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology[Mal de débarquement syndrome – “sickness of disembarkment”].
Orvosi hetilapMal de Debarquement Syndrome: A Rare Entity.
CureusMal de Debarquement Syndrome.
Seminars in neurologyDedication to Mingjia Dai, Ph.D. for Discovery of the First Successful Treatment of the Mal de Debarquement Syndrome.
Frontiers in neurology[The Mal de Débarquement Syndrome].
Revue medicale suisseOccipital and Cerebellar Theta Burst Stimulation for Mal De Debarquement Syndrome.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyPilot study on patients with Mal de Debarquement syndrome during pregnancy.
Future science OAApproach to an experimental model of Mal de Debarquement Syndrome.
Journal of neurologyMultimodal Imaging of Repetitive Transcranial Magnetic Stimulation Effect on Brain Network: A Combined Electroencephalogram and Functional Magnetic Resonance Imaging Study.
Brain connectivityExamination of Current Treatments and Symptom Management Strategies Used by Patients With Mal De Debarquement Syndrome.
Frontiers in neurologyEffect of Body Positions on EEG signals in Mal de Debarquement Syndrome.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International ConferenceMal de Debarquement Syndrome: A Case Report.
CureusSham-Controlled Study of Optokinetic Stimuli as Treatment for Mal de Debarquement Syndrome.
Frontiers in neurologyA new theory on GABA and Calcitonin Gene-Related Peptide involvement in Mal de Debarquement Syndrome predisposition factors and pathophysiology.
Medical hypothesesElectrophysiological Signatures of Intrinsic Functional Connectivity Related to rTMS Treatment for Mal de Debarquement Syndrome.
Brain topographyMal de Debarquement Syndrome: A Retrospective Online Questionnaire on the Influences of Gonadal Hormones in Relation to Onset and Symptom Fluctuation.
Frontiers in neurologyComprehensive Clinical Profile of Mal De Debarquement Syndrome.
Frontiers in neurologyTreatment of Mal de Debarquement Syndrome in a Deployed Environment.
Military medicinePerspective: Stepping Stones to Unraveling the Pathophysiology of Mal de Debarquement Syndrome with Neuroimaging.
Frontiers in neurologyHypothesis: The Vestibular and Cerebellar Basis of the Mal de Debarquement Syndrome.
Frontiers in neurologyMal de Debarquement Syndrome: a survey on subtypes, misdiagnoses, onset and associated psychological features.
Journal of neurologyAssessing rTMS effects in MdDS: Cross-modal comparison between resting state EEG and fMRI connectivity.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International ConferenceResting State Functional Connectivity Signature of Treatment Effects of Repetitive Transcranial Magnetic Stimulation in Mal de Debarquement Syndrome.
Brain connectivityScuba diving and otology: a systematic review with recommendations on diagnosis, treatment and post-operative care.
Diving and hyperbaric medicineTreatment of the Mal de Debarquement Syndrome: A 1-Year Follow-up.
Frontiers in neurologyOptimizing rTMS treatment of a balance disorder with EEG neural synchrony and functional connectivity.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International ConferenceManagement of mal de debarquement syndrome as vestibular migraines.
The LaryngoscopeMal de débarquement syndrome.
Handbook of clinical neurologyDouble-Blind Sham-Controlled Crossover Trial of Repetitive Transcranial Magnetic Stimulation for Mal de Debarquement Syndrome.
Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and NeurotologyRandomized Single Blind Sham Controlled Trial of Adjunctive Home-Based tDCS after rTMS for Mal De Debarquement Syndrome: Safety, Efficacy, and Participant Satisfaction Assessment.
Brain stimulationMal de debarquement syndrome: a systematic review.
Journal of neurologyMal de Debarquement Syndrome: A Rare Entity-A Case Report and Review of the Literature.
Case reports in otolaryngologyVoxel Based Morphometry Alterations in Mal de Debarquement Syndrome.
PloS oneMedical and Nonstroke Neurologic Causes of Acute, Continuous Vestibular Symptoms.
Neurologic clinicsMal de débarquement syndrome: Review and proposed diagnostic criteria.
Neurology. Clinical practiceEfficacy of neurostimulation to treat symptoms of Mal de Debarquement Syndrome. A preliminary study using repetitive transcranial magnetic stimulation.
Journal of neuropsychologyMal de debarquement syndrome: new insights.
Annals of the New York Academy of Sciences[Mal de debarquement: a case report].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgeryChanges of symptom and EEG in mal de debarquement syndrome patients after repetitive transcranial magnetic stimulation over bilateral prefrontal cortex: a pilot study.
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International ConferenceAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Update on functional vestibular and gait disorders.
- Corrigendum to "Mal de Debarquement Syndrome in Children: A Case Series" The Journal of Pediatrics 259 (2023):113435.
- Motion Exposure, Cognitive Impairment, and Risk Factors for Mal de Débarquement Syndrome.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery· 2026· PMID 41774616mais citado
- Potential lesson from a model-based exploration on treatment effect heterogeneity of mal de débarquement syndrome.
- Dizziness: When Is It Migraine, and When Is It Not?
- [Mal de Débarquement Syndrome - a poorly understood and rare condition in clinical practice].
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:210272(Orphanet)
- MONDO:0016217(MONDO)
- GARD:6959(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q3480741(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
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