Uma doença inflamatória que tem a ver com a IgG4, um tipo de anticorpo, e que afeta o olho.
Introdução
O que você precisa saber de cara
Uma doença inflamatória que tem a ver com a IgG4, um tipo de anticorpo, e que afeta o olho.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 32 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 65 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Doença oftalmológica IgG4-relacionada
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Pesquisa e ensaios clínicos
3 ensaios clínicos encontrados, 1 ativos.
Publicações mais relevantes
Single-cell atlas of B cell heterogeneity in lacrimal IgG4-related disorders: Unraveling the transition from inflammatory exhaustion to clonal malignancy.
This study analyzed B-cell heterogeneity in lacrimal gland tissues from 4 patients with IgG4-related ophthalmic disease (IgG4-ROD) and 2 patients with IgG4-positive MALT lymphoma using single-cell transcriptome sequencing (scRNA-seq). The results revealed that while the B-cell differentiation trajectories have similarities between the two diseases, critical differences were evident. IgG4-ROD was predominantly composed of naïve B cells, with memory B cells mainly being the central memory type. These cells were enriched in hormone/innate immunity pathways, and the plasma cells exhibited features of functional exhaustion. Conversely, MALT lymphoma was dominated by memory B cells, particularly enriched in terminally differentiated subtypes, with aberrant activation of oncogenic pathways (BCR/NF-κB). In MALT lymphoma, naïve B cells showed upregulated expression of immunoglobulin genes (IGHG3/IGHG4) and abnormal activation of EBV/BCR/T-cell differentiation pathways, despite having suppressed basal metabolism. Germinal center-like B cells in MALT lymphoma revealed upregulated gene expression enriched in T-cell activation and PD-1/PD-L1 pathways. Plasma cells in MALT lymphoma displayed monoclonal expansion (high expression of IGHG2/IGHG3/IGHG4) and enhanced antibody secretion. Therefore, MALT lymphoma is characterized by abnormal activation and malignant transformation of B cells, whereas IgG4-ROD manifests as functional exhaustion and metabolic suppression. The differentiation state of memory B cells may represent a critical juncture for malignant transformation.
Application of artificial intelligence in differentiating IgG4-related ophthalmic disease and orbital MALT lymphoma: a review of radiomics and deep learning advances.
The differentiation between Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) and orbital lymphoma, particularly the mucosa-associated lymphoid tissue (MALT) subtype, presents a significant clinical challenge due to overlapping imaging features and similar presentations. Recent advances in artificial intelligence (AI), particularly radiomics and deep learning, have shown promising potential in enhancing diagnostic accuracy by extracting high-dimensional imaging features and constructing robust predictive models. This review systematically examines the current state of AI applications in distinguishing IgG4-ROD from orbital MALT lymphoma, highlighting key methodologies in image-based feature extraction, model development, and diagnostic performance evaluation. We explore various AI techniques applied to multimodal imaging data integration and discuss optimization strategies for deep learning architectures tailored to this clinical context. Additionally, the review addresses the practical challenges and limitations of translating AI-assisted diagnostic tools into routine clinical practice, including issues related to small sample sizes, retrospective single-center designs, data variability, interpretability, and the critical need for robust external validation. By synthesizing recent research findings, this review aims to provide a comprehensive overview of AI-driven diagnostic advances, critically assess current challenges, and propose future directions to improve the accuracy and reliability of orbital disease differentiation, ultimately supporting more precise clinical decision-making.
Clinical significance of serum IgE levels in IgG4-related ophthalmic disease: a single-centre study.
To explore the role of serum IgE in IgG4-related ophthalmic disease (IgG4-ROD) by comparing clinical features and prognosis of patients with elevated and normal serum IgE levels. This single-centre retrospective study included 54 IgG4-ROD patients diagnosed by histopathology from March 2022 to March 2024. Clinical features of the IgE+ group (serum IgE levels >165 IU/ml) and the IgE- group (serum IgE levels ≤ 165 IU/ml) were compared, and 50 patients were followed for at least 6 months to assess the prognosis. Statistical analyses included t tests, Mann-Whitney U, chi-square tests, Spearman correlation, Kaplan-Meier survival curves, and Cox regression. Among the 54 patients, both the IgE+ (n = 22) and IgE- groups (n = 32) were predominantly middle-aged women. Extraocular muscle involvement was more common in the IgE- group (P = 0.033), whereas bilateral ocular (P = 0.040) and sinus involvement (P = 0.046) were more frequent in the IgE+ group. Significant intergroup differences were observed in serum IgG4 (P = 0.004), C1q (P = 0.021), IL-10 levels (P = 0.030), IgG4/IgG (P = 0.022), and IgE/IgG4 ratios (P = 0.018). Serum IgE correlated positively with IgG4, IL-6, IL-10, and IL-12p70, and negatively with C1q and IgM (P < 0.05). The IgE+ group had a higher relapse risk (P = 0.038). Cox regression analysis identified serum IgE as an independent risk factor for relapse (P = 0.022). Elevated serum IgE in IgG4-ROD is associated with more severe disease and higher relapse risk, highlighting its potential as a prognostic marker.
Autoimmune fibroinflammation in IgG4-related ophthalmic disease: TLR8-dependent signaling pathways and fibrotic remodeling revealed by proteomic profiling.
Immunoglobulin G4-related ophthalmic disease (IgG4-ROD) is an immune-mediated ocular condition characterized by tumefactive lesions with IgG4+ plasma cell infiltration, and commonly affecting the lacrimal gland, extraocular muscles, and trigeminal nerves.The precise pathogenesis of IgG4-ROD remains unclear. Elucidating its molecular mechanisms is crucial for the development of targeted molecular therapies. To investigate the molecular pathogenesis of IgG4-ROD, we conducted a case-controlled study involving 15 patients who presented at the Second Hospital of Jilin University between 2021 and 2022. In accordance with the comprehensive diagnostic criteria for IgG4-related disease (IgG4-RD) established in 2011, participants were stratified into three distinct cohorts based on lacrimal gland histopathological findings: confirmed IgG4-ROD, suspected IgG4-ROD, and a control group. We then utilized 4D-Fast DIA technology to acquire proteomic profiles from the lacrimal gland biopsies, with rigorous bioinformatics methodologies employed to process and interpret these data, focusing on the differential protein expression patterns across the groups, aiming to identify signaling pathways that are significantly associated with IgG4-ROD. The comparative analysis of clinical characteristics, imaging features, and histopathological findings among the control group, patients with suspected IgG4-ROD, and diagnosed patients revealed a progressive trend towards more severe pathology. Principal component analysis (PCA) and Pearson correlation heatmaps indicated that the profiles of differentially expressed proteins in lacrimal gland samples from the suspected and diagnosed groups were highly similar, suggesting that the patients from these two groups may belong to the same population. Further analysis of protein expression changes across the three groups revealed significant enrichment in pathways related to asthma, Th1 and Th2 cell differentiation, and other relevant signaling pathways. Notably, Toll-like receptor (TLR), NF-κB, Wnt, and PI3K-AKT signaling pathways were prominently activated. In the diagnosed group, proteins such as MMP7, POSTN, and CD163 exhibited characteristic high-level expression. Furthermore, compared with the suspected group, the diagnosed group showed significant downregulation of proteins related to elastin fibers, indicating a more severe degree of fibrosis in the lacrimal gland tissues. Additionally, the diagnosed group exhibited a significant decrease in proteins associated with lacrimal secretion, suggesting impaired function of lacrimal gland. We also observed a notable upregulation of TLR-8-related proteins in both the suspected and diagnosed groups, implying that the TLR signaling pathway may be closely related to this disease. Proteomic analysis of lacrimal gland samples from the diagnosed, suspected, and control groups suggests that patients with suspected IgG4-ROD may be part of the same population as diagnosed patients. In the diagnosed group, the lacrimal gland tissue displayed more severe fibrosis and a significant loss of lacrimal secretion function. This study postulates that the TLR - 8/IRAK4/NF - κB pathway may contribute to the molecular pathogenesis of IgG4 - ROD by promoting tissue fibrosis. Proteins such as MMP7, POSTN, and CD163 could potentially serve as molecular markers for the early diagnosis and potential therapeutic targets of IgG4 - ROD. Based on these findings, proteomics offers significant advantages in the molecular diagnosis of IgG4 - ROD and should be regarded as a crucial tool in the diagnosis of this disease.
Bilateral orbital masses caused by IgG4-expressing MALT lymphoma in the right side and IgG4-related ophthalmic disease in the left side: A case report.
A 60-year-old Japanese man developed a protruding right eye. He underwent a magnetic resonance imaging scan, which revealed a right orbital mass. The serum immunoglobulin G4 (IgG4) level was elevated, and IgG4+ plasma cells were observed in biopsy specimens of the mass. The result of biopsy and Southern blot analysis revealed that the mass was caused by IgG4+ extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue. He received a total of 36 Gy of radiation therapy, and the mass disappeared. Five years later, he developed a protruding left eye. The magnetic resonance imaging scan at that time revealed a left orbital mass. Biopsy revealed findings of IgG4-related disease in the left orbital mass, but no findings of mucosa-associated lymphoid tissue lymphoma. He has been followed up without glucocorticoid treatment. Here, we report a patient who developed IgG4+ MALT lymphoma in the right orbital mass and IgG4-related ophthalmic disease in the left orbital mass. Because the treatment strategy for IgG4-related ophthalmic disease and malignant lymphoma is completely different, we emphasise the need for biopsy.
Publicações recentes
Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease.
CT-guided biopsy with fine-needle via the anterior approach in the diagnosis of orbital lymphoma: a case series.
Exploring the intersection: adult orbital xanthogranulomatous disease and IgG4-related disease - report of 3 cases and literature review.
Single-cell atlas of B cell heterogeneity in lacrimal IgG4-related disorders: Unraveling the transition from inflammatory exhaustion to clonal malignancy.
Application of artificial intelligence in differentiating IgG4-related ophthalmic disease and orbital MALT lymphoma: a review of radiomics and deep learning advances.
📚 EuropePMC102 artigos no totalmostrando 155
Single-cell atlas of B cell heterogeneity in lacrimal IgG4-related disorders: Unraveling the transition from inflammatory exhaustion to clonal malignancy.
The FEBS journalApplication of artificial intelligence in differentiating IgG4-related ophthalmic disease and orbital MALT lymphoma: a review of radiomics and deep learning advances.
Frontiers in immunologyClinical significance of serum IgE levels in IgG4-related ophthalmic disease: a single-centre study.
Eye (London, England)Autoimmune fibroinflammation in IgG4-related ophthalmic disease: TLR8-dependent signaling pathways and fibrotic remodeling revealed by proteomic profiling.
Frontiers in immunologyBilateral orbital masses caused by IgG4-expressing MALT lymphoma in the right side and IgG4-related ophthalmic disease in the left side: A case report.
Modern rheumatology case reportsA patient-specific multidisciplinary approach to improve patient outcomes in IgG4-related ophthalmic disease.
Indian journal of ophthalmologyParadoxical Development of IgG4-Related Ophthalmic Disease During Dupilumab Therapy.
Seminars in ophthalmologyAdvancing the diagnosis of IgG4-related ophthalmic disease: a critical appraisal of current criteria.
Journal of clinical pathologyClinicopathological features differentiating Castleman Disease from IgG4-related ophthalmic disease, a 10 years retrospective study.
Indian journal of ophthalmologyCase Report: IgG4-related ophthalmic disease presenting with unilateral proptosis.
Frontiers in immunologyComparison of volumetric responses to different corticosteroid administration methods in IgG4-related ophthalmic disease.
PloS oneIgG4-Positive Conjunctival Tumor with Systemic Allergy: A Case Report.
Ocular immunology and inflammationGut microbiome alterations in IgG4-related ophthalmic disease.
BMC microbiologyOrbital and Adnexal IgG4-related disease: An insight into the clinical profile and management outcomes.
Indian journal of ophthalmologyApplications of New Generation Sequencing (NGS) in Ocular Oncology.
International ophthalmology clinicsChronic Dacryocystitis With Elevated IgG4-Plasma Cells in a Patient With Rubinstein-Taybi Syndrome: An IgG4-Related Disease?
Ophthalmic plastic and reconstructive surgeryA case of IgG4-related ophthalmic disease with bone destruction presenting as unilateral painful blepharitis.
International journal of ophthalmologyAnterior scleritis with IgG4 lymphoplasmacytic infiltration: a case report.
Journal of ophthalmic inflammation and infectionGene expression cluster differences and molecular correlation with the STING pathway in orbital MALT lymphoma and orbital IgG4-related eye disease.
Discover oncologyA Case in Which the Endoscopic Denker's Approach Was Useful in the Diagnosis of IgG4-Related Ophthalmic Disease.
CureusIgG4-Related Ophthalmic Disease with Proptosis.
Balkan medical journalLabial salivary gland biopsy for diagnosing immunoglobulin G4-related ophthalmic disease with optic neuropathy: a case report.
Orbit (Amsterdam, Netherlands)Periocular Manifestations and Management of Immunoglobulin G4-Related Disease.
International ophthalmology clinicsPerilesional dominance: radiomics of multiparametric MRI enhances differentiation of IgG4-Related ophthalmic disease and orbital MALT lymphoma.
BMC medical imagingImmunoglobulin G4-related ophthalmic disease with orbital deep hemangioma: A case report.
The Journal of international medical researchOrbital inflammatory disease in a primarily black patient population.
Frontiers in ophthalmologyAdult-Onset Asthma With Periocular Xanthogranuloma (AAPOX) Associated With IgG4-Related Disorder: A Case Report and Review of Current Literature.
CureusA Case of IgG4-Related Disease Presenting With Concurrent Uveitis, Posterior Scleritis, Serous Retinal Detachment, and Choroidal Thickening Mimicking Intraocular Lymphoma.
CureusSAPHO syndrome complicated by IgG4-related ophthalmic disease: a case report and literature review.
Frontiers in immunologyImmunoglobulin G4-Related Ophthalmic Disease: A Nationwide Multicenter Study in Korea.
OphthalmologyIgG4-related ophthalmic disease presenting as posterior scleritis in a pediatric patient.
Journal of ophthalmic inflammation and infectionSingle-cell RNA-sequencing reveals cellular heterogeneity and immune microenvironment characteristics between ocular adnexal mucosa-associated lymphoid lymphoma and IgG4-related ophthalmic disease.
Frontiers in immunologyExtensive Involvement of the Bilateral Trigeminal Nerve Branch as the Only Imaging Manifestation of IgG4‑Related Ophthalmic Disease.
Journal of the Belgian Society of RadiologySuccessful glucocorticoid treatment case for IgG4-related long-standing optic neuropathy.
Modern rheumatology case reportsSimilarities and differences of a proliferation-inducing ligand expression in lacrimal gland lesions of patients with IgG4-associated ophthalmic diseases and mucosa-associated lymphoid tissue lymphoma.
Frontiers in immunologyNormative measurements of the frontal nerve by magnetic resonance imaging in an Australia cohort.
Surgical and radiologic anatomy : SRAPostoperative outcomes of biopsy versus debulking surgery for immunoglobulin G4-related ophthalmic disease: a retrospective comparative study.
Japanese journal of ophthalmologyComparison between Immunoglobulin G4-Related Eye Disease and Other Entities with Non-Immunoglobulin G4 Ocular Involvement.
European journal of rheumatologyAdvances in understanding and management of IgG4-related ophthalmic disease.
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)Evaluation of the specificity of trigeminal nerve enlargement in the diagnosis of IgG4-related ophthalmic disease.
Japanese journal of ophthalmologyIL-33/ST2 enhances MMP-12 expression by macrophages to mediate inflammatory and immune response in IgG4-Related Ophthalmic Disease.
CytokineNormative Measurements of the Infraorbital Nerve by Magnetic Resonance Imaging in an Australia Cohort.
Ophthalmic plastic and reconstructive surgeryAssessing IgG4-related ophthalmic disease and its mimics: a comparison of ACR/EULAR, organ-specific and revised comprehensive diagnostic criteria.
Journal of clinical pathologyThe 2023 revised diagnostic criteria for IgG4-related ophthalmic disease.
Japanese journal of ophthalmologyUnraveling the Clinical Features and Outcomes of IgG4-Related Ophthalmic Disease.
Journal of clinical medicineInfraorbital nerve involvement as a pathognomonic sign of IgG4-related ophthalmic disease.
Joint bone spineClinical characteristics and treatment outcomes of patients with IgG4-positive ocular adnexal marginal zone B-cell lymphoma.
Indian journal of ophthalmologyArtificial intelligence-based differential diagnosis of orbital MALT lymphoma and IgG4 related ophthalmic disease using hematoxylin-eosin images.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieA case of IgG4-related ophthalmic disease after SARS-CoV-2 vaccination: case report and literature review.
Frontiers in immunologyIgG4-related uveitis. A French cohort and literature review.
Seminars in arthritis and rheumatismSuccessful remission induction of IgG4-related ophthalmic disease by obinutuzumab therapy: a retrospective study of 8 patients.
Eye (London, England)IgG4-Related Ophthalmic Disease following COVID-19 Infection: Is it Associated or Incidental?
Klinische Monatsblatter fur AugenheilkundeRadiomics analysis of T1WI and T2WI magnetic resonance images to differentiate between IgG4-related ophthalmic disease and orbital MALT lymphoma.
BMC ophthalmologyEfficacy and safety of intravenous glucocorticoid therapy for IgG4-related ophthalmic disease.
PloS oneIgG4-related ophthalmic disease masquerading as ciliary body tumors and scleritis in both eyes: a case report.
BMC ophthalmologyIgG4-related disease presenting with profound bilateral orbital and adnexal inflammation.
American journal of ophthalmology case reportsLong-Term Follow-Up in IgG4-Related Ophthalmic Disease: Serum IgG4 Levels and Their Clinical Relevance.
Journal of personalized medicine[Cerebral venous sinus thrombosis presenting transient ischemic attack after recovery from COVID-19 with Graves' disease and IgG4-related ophthalmic disease: a case report].
Rinsho shinkeigaku = Clinical neurologyTreatment outcomes and their determinants of IgG4-related ophthalmic disease: a territory-wide cohort study.
The British journal of ophthalmologyProbable IGG4 related ophthalmic disease presenting with uveitis.
Orbit (Amsterdam, Netherlands)Local recurrence as extraocular muscle lymphoma after 6 years of chronic myositis: a case report.
BMC ophthalmologyA Case of Immunoglobulin G4-Related Ophthalmic Disease With Unilateral Visual Field Impairment.
CureusIgG4-related disease as multiple head and neck swellings: supported by histopathology and immunohistochemistry.
Romanian journal of ophthalmologyLacrimal Gland and Orbital Lesions in LatY136F Knock-in Mice, a Model for Human IgG4-Related Ophthalmic Disease.
Current eye researchApocrine Hidrocystoma with IgG4 Plasma Cell Infiltration Presenting as Recurrent Chalazion: A Case Report.
Medicina (Kaunas, Lithuania)IgG4-Related Ophthalmic Disease.
The New England journal of medicineMalignancies in Immunoglobulin G4-related ophthalmic disease.
European journal of ophthalmologyPathological count of IgG4-positive plasmacytes suggests extraophthalmic involvement and relapse in patients with IgG4-related ophthalmic disease: a retrospective study.
Arthritis research & therapyIgG4-related hypertensive granulomatous anterior uveitis.
American journal of ophthalmology case reportsActivation of Mast-Cell-Derived Chymase in the Lacrimal Glands of Patients with IgG4-Related Ophthalmic Disease.
International journal of molecular sciencesThe Role of Symptom Duration and Serologic Factors in the Relapse of IgG4-Related Ophthalmic Disease following Surgery: A Retrospective Cohort Study.
Disease markersRe: "Clinical Outcomes of IgG4-Related Ophthalmic Disease and Idiopathic Sclerosing Orbital Inflammation".
Ophthalmic plastic and reconstructive surgeryCases with IgG4-related ophthalmic disease with mass lesions surrounding the optic nerve.
American journal of ophthalmology case reportsLong-Term Outcomes of IgG4-Related Ophthalmic Disease in a Chinese IgG4-Related Disease Cohort.
Frontiers in medicineOphthalmic involvement disparities in clinical characteristics of IgG4-related disease: a retrospective study of 573 patients.
BMC ophthalmologyIgG4-related ophthalmic disease in association with adult-onset asthma and periocular xanthogranuloma: a case report.
Orbit (Amsterdam, Netherlands)Clinical analysis of ocular adnexal mucosa-associated lymphoid tissue lymphoma with IgG4-related ophthalmic disease.
Orbit (Amsterdam, Netherlands)F-18 Fluorodeoxyglucose PET/CT as a Diagnostic Tool in Orbital Inflammatory Disorders.
Ocular immunology and inflammationClinico-epidemiological analysis of 1000 cases of orbital tumors.
Japanese journal of ophthalmologyIgG4-related disease of the orbit in an infant.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and StrabismusClinical features and symptoms of IgG4-related ophthalmic disease: a multicenter study.
Japanese journal of ophthalmologyLow-dose 'boom-boom' radiotherapy for ocular lymphoma arising from IgG4-related ophthalmic disease: Case report and literature review.
European journal of ophthalmologyIgG4-related disease in pediatric patients: a single-center experience.
Rheumatology internationalUpregulated Expression of Activation-Induced Cytidine Deaminase in Ocular Adnexal Marginal Zone Lymphoma with IgG4-Positive Cells.
International journal of molecular sciences[IgG4-related ophthalmic disease: three-case report].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmologyClinical features and relapse risks of IgG4-related ophthalmic disease: a single-center experience in China.
Arthritis research & therapyClinical Outcomes of IgG4-Related Ophthalmic Disease and Idiopathic Sclerosing Orbital Inflammation.
Ophthalmic plastic and reconstructive surgeryMorphologic Cross-Sectional Imaging Features of IgG4-Related Orbitopathy in Comparison to Ocular Adnexal Lymphoma.
Clinical ophthalmology (Auckland, N.Z.)Follow-up with serum IgG4-monitoring in 8 patients with IgG4-related disease diagnosed by a lacrimal gland mass.
Journal of clinical and experimental hematopathology : JCEHTo Explore MR Imaging Radiomics for the Differentiation of Orbital Lymphoma and IgG4-Related Ophthalmic Disease.
BioMed research internationalSurgical management for IgG4-related ophthalmic disease by a transcranial biopsy combined with extraorbital decompression: illustrative case.
Journal of neurosurgery. Case lessonsDifferential Tissue Metabolic Signatures in IgG4-Related Ophthalmic Disease and Orbital Mucosa-Associated Lymphoid Tissue Lymphoma.
Investigative ophthalmology & visual scienceIdentification of Markers Predicting Clinical Course in Patients with IgG4-Related Ophthalmic Disease by Unbiased Clustering Analysis.
Journal of clinical medicineRadiologic imaging shows variable accuracy in diagnosing orbital inflammatory disease and assessing its activity.
Scientific reports[The imaging signs and significances of the enlargement of the infraorbital nerve and the frontal nerve in orbital lymphoproliferative diseases].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmologyComprehensive Gene Analysis of IgG4-Related Ophthalmic Disease Using RNA Sequencing.
Journal of clinical medicineImage-Guided Intensity-Modulated Radiation Therapy for IgG4-Related Ophthalmic Disease.
Case reports in ophthalmological medicineDistinctive Tissue and Serum MicroRNA Profile of IgG4-Related Ophthalmic Disease and MALT Lymphoma.
Journal of clinical medicineA Case of IgG4-Related Ophthalmic Disease With Coronary Arteritis.
Ophthalmic plastic and reconstructive surgeryClinical features and outcomes of IgG4-related idiopathic orbital inflammatory disease: from a large southern China-based cohort.
Eye (London, England)Alteration of Cell Surface Markers CD38 and CD138 in Lymphoproliferative Disorders in the Ocular Adnexa.
Anticancer researchCorticosteroid Withdrawal after Complete Resection of Recurrent IgG4-Related Ophthalmic Disease.
Neuro-ophthalmology (Aeolus Press)Bilateral IgG4-related Ophthalmic Disease With Diffuse Large B-cell Lymphoma of the Right Eye: A Case Report.
Ophthalmic plastic and reconstructive surgeryOrbital inflammation and colitis in pediatric IgG4-related disease: A case report and review of the literature.
European journal of rheumatology[Clinical and pathological study on IgG4-related ophthalmic disease involving the lacrimal gland].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmologyThe natural course of IgG4-related ophthalmic disease after debulking surgery: a single-centre retrospective study.
BMJ open ophthalmologyIgG4-Related Ophthalmic Disease Presenting as Meningitis and Panuveitis.
Case reports in ophthalmological medicineMULTIMODAL IMAGING OF IGG4-RELATED PAPILLITIS AND RETINAL DISEASE.
Retinal cases & brief reportsLong-term outcomes of ocular adnexal lesions in IgG4-related ophthalmic disease.
The British journal of ophthalmologyMagnetic resonance imaging indicator of the causes of optic neuropathy in IgG4-related ophthalmic disease.
BMC medical imagingIgG4-related Ophthalmic Disease in Idiopathic Sclerosing and Non-Sclerosing Orbital Inflammation: A 25-Year Experience.
Current eye researchIgG4-positive Cell Quantification Distinguishes Between Inflammatory and Noninflammatory Diseases of the Orbit.
Applied immunohistochemistry & molecular morphology : AIMMOccult Nasolacrimal Duct Obstruction Secondary to IgG4-Related Ophthalmic Disease.
Ophthalmic plastic and reconstructive surgeryDiagnosis of IgG4 - related ophthalmic disease in a group of patients with various lesions of the eye and orbits.
Terapevticheskii arkhivIgG4-related disease in patients with idiopathic orbital inflammation syndrome: data from the French SIOI prospective cohort.
Acta ophthalmologicaPurpura fulminans with Lemierre's syndrome caused by Gemella bergeri and Eikenella corrodens: a case report.
BMC infectious diseasesA clinicopathological study on IgG4-related ophthalmic disease.
International journal of ophthalmologyDistinguishing IgG4-Related Ophthalmic Disease From Graves Orbitopathy.
Ophthalmic plastic and reconstructive surgeryA case of fatal osteolytic hypercalcemia complicated with IgG4-related ophthalmic disease leading to renal failure.
CEN case reportsThe Case of IgG4-Related Ophthalmic Disease with Perivascular Lesions of Superior Ophthalmic Vein Associated with Optic Nerve Disturbance.
Neuro-ophthalmology (Aeolus Press)The Case of IgG4-related Ophthalmic Disease Accompanied by Compressive Optic Neuropathy.
Neuro-ophthalmology (Aeolus Press)[Clinical analysis of patients with orbital nonspecific inflammatory response diseases whose CT or MR images show enlargement of the infraorbital nerves].
[Zhonghua yan ke za zhi] Chinese journal of ophthalmologyIgG4-related ophthalmic disease involving extraocular muscles: case series.
BMC ophthalmologyLongstanding IgG4-related Ophthalmic Disease Dramatically Improved after Steroid Therapy.
Internal medicine (Tokyo, Japan)Orbital progressive transformation of germinal centers as part of the spectrum of IgG4-related ophthalmic disease: Clinicopathologic features of three cases.
Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyImmunoglobulin G4-related ophthalmic disease.
Taiwan journal of ophthalmologyImmunoglobulin G4-Related Disease: An Update.
Oman medical journalInfraorbital Nerve Involvement on Magnetic Resonance Imaging in Igg4-Related Ophthalmic Disease: A Highly Suggestive Sign.
OphthalmologyImmunoglobulin G4-related dacyroadenitis presenting as bilateral chorioretinal folds from severely enlarged lacrimal glands.
American journal of ophthalmology case reportsClinicoserological factors associated with response to steroid treatment and recurrence in patients with IgG4-related ophthalmic disease.
The British journal of ophthalmologyThe 2017 Doyne Lecture: the orbit as a window to systemic disease.
Eye (London, England)Clinical outcomes and pathological characteristics of immunoglobulin G4-related ophthalmic disease versus orbital inflammatory pseudotumor.
The Korean journal of internal medicineFrequency and distribution of CD4+CXCR5+ follicular B helper T cells within involved tissues in IgG4‑related ophthalmic disease.
Molecular medicine reportsRisk factors for extraophthalmic involvement and treatment outcomes in patients with IgG4-related ophthalmic disease.
The British journal of ophthalmologyRepeat Biopsy of IgG4-Related Ophthalmic Disease Identifies Superimposed Herpes Simplex Virus Infection: A Case Report.
Ocular immunology and inflammationUsefulness of Flow Cytometry in Diagnosis of IgG4-Related Ophthalmic Disease and Extranodal Marginal Zone B-Cell Lymphoma of the Ocular Adnexa.
Anticancer researchIgG4-related disease in the eye and ocular adnexa.
Current opinion in ophthalmologyChange of Serum IgG4 in Patients with Ocular Adnexal Marginal Zone B Cell Lymphoma Associated with IgG4-Related Ophthalmic Disease After Treatment.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and TherapeuticsImmunophenotypic profiles for distinguishing orbital mucosa-associated lymphoid tissue lymphoma from benign lymphoproliferative tumors.
Japanese journal of ophthalmologyIGG4-RELATED OPHTHALMIC DISEASE PRESENTING AS CHOROIDAL AND ORBITAL LESIONS.
Retinal cases & brief reportsOphthalmic manifestations in IgG4-related disease: Clinical presentation and response to treatment in a French case-series.
MedicineImmunoglobulin G4-Related Ophthalmic Disease Involving the Sclera Misdiagnosed as Intraocular Tumor: Report of One Case.
Ocular oncology and pathologyOrbital Involvement and Ocular Surface Changes in IgG4-Related Systemic Disease.
CorneaOcular adnexal marginal zone lymphoma arising in a patient with IgG4-related ophthalmic disease.
Modern rheumatologyInfraorbital nerve involvement on magnetic resonance imaging in European patients with IgG4-related ophthalmic disease: a specific sign.
European radiology[Diagnostic Criteria for IgG4-related Ophthalmic Disease].
Nippon Ganka Gakkai zasshiIgG4-related disease presenting as hypertrophic pachymeningitis and compressive optic neuropathy.
Joint bone spineBilateral IgG4-related ophthalmic disease: a strong indication for systemic imaging.
The British journal of ophthalmologyIgG4 Staining in Thyroid Eye Disease.
Ophthalmic plastic and reconstructive surgeryIntraorbital corticosteroid injection for the treatment of IgG4-related ophthalmic disease.
The British journal of ophthalmologyImmunoglobulin G4-related ophthalmic disease presenting as uveitis.
Journal of clinical neuroscience : official journal of the Neurosurgical Society of AustralasiaIgG4-Related Ophthalmic Disease: Pooling of Published Cases and Literature Review.
Current allergy and asthma reportsGenome-Wide Analysis of Ocular Adnexal Lymphoproliferative Disorders Using High-Resolution Single Nucleotide Polymorphism Array.
Investigative ophthalmology & visual scienceIgG4-Related Ophthalmic Disease. Part II: Clinical Aspects.
Ophthalmic plastic and reconstructive surgeryIgG4-related ophthalmic disease. Part I: background and pathology.
Ophthalmic plastic and reconstructive surgeryAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Doença oftalmológica IgG4-relacionada.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Doença oftalmológica IgG4-relacionada
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Single-cell atlas of B cell heterogeneity in lacrimal IgG4-related disorders: Unraveling the transition from inflammatory exhaustion to clonal malignancy.
- Application of artificial intelligence in differentiating IgG4-related ophthalmic disease and orbital MALT lymphoma: a review of radiomics and deep learning advances.
- Clinical significance of serum IgE levels in IgG4-related ophthalmic disease: a single-centre study.
- Autoimmune fibroinflammation in IgG4-related ophthalmic disease: TLR8-dependent signaling pathways and fibrotic remodeling revealed by proteomic profiling.
- Bilateral orbital masses caused by IgG4-expressing MALT lymphoma in the right side and IgG4-related ophthalmic disease in the left side: A case report.
- Clinicopathological and Imaging Distinction Between Ocular Adnexal MALT Lymphoma and IgG4-Related Ophthalmic Disease.
- CT-guided biopsy with fine-needle via the anterior approach in the diagnosis of orbital lymphoma: a case series.
- Exploring the intersection: adult orbital xanthogranulomatous disease and IgG4-related disease - report of 3 cases and literature review.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:449563(Orphanet)
- MONDO:0018675(MONDO)
- GARD:21885(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q25312948(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
