O carcinoma da vesícula biliar (CGB) é a forma mais comum e agressiva de câncer do trato biliar (CBT), geralmente surgindo no fundo da vesícula biliar, metastatizando rapidamente para gânglios linfáticos e locais distantes.
Introdução
O que você precisa saber de cara
O carcinoma da vesícula biliar (CGB) é a forma mais comum e agressiva de câncer do trato biliar (CBT), geralmente surgindo no fundo da vesícula biliar, metastatizando rapidamente para gânglios linfáticos e locais distantes.
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Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 6 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 14 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
4 genes identificados com associação a esta condição. Padrão de herança: Not applicable.
E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage (PubMed:10500182, PubMed:12887909, PubMed:12890688, PubMed:14976165, PubMed:16818604, PubMed:17525340, PubMed:19261748). It is unclear whether it also mediates the formation of other types of polyubiquitin chains (PubMed:12890688). The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular path
NucleusChromosomeCytoplasm
Breast cancer
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Involved in double-strand break repair and/or homologous recombination. Binds RAD51 and potentiates recombinational DNA repair by promoting assembly of RAD51 onto single-stranded DNA (ssDNA). Acts by targeting RAD51 to ssDNA over double-stranded DNA, enabling RAD51 to displace replication protein-A (RPA) from ssDNA and stabilizing RAD51-ssDNA filaments by blocking ATP hydrolysis. Part of a PALB2-scaffolded HR complex containing RAD51C and which is thought to play a role in DNA repair by HR. May
NucleusCytoplasm, cytoskeleton, microtubule organizing center, centrosome
Breast cancer
A common malignancy originating from breast epithelial tissue. Breast neoplasms can be distinguished by their histologic pattern. Invasive ductal carcinoma is by far the most common type. Breast cancer is etiologically and genetically heterogeneous. Important genetic factors have been indicated by familial occurrence and bilateral involvement. Mutations at more than one locus can be involved in different families or even in the same case.
Receptor tyrosine kinase (RTK) that plays a role in epithelial cell differentiation and regionalization of the proximal epididymal epithelium. NELL2 is an endogenous ligand for ROS1. Upon endogenous stimulation by NELL2, ROS1 activates the intracellular signaling pathway and triggers epididymal epithelial differentiation and subsequent sperm maturation (By similarity). May activate several downstream signaling pathways related to cell differentiation, proliferation, growth and survival including
Cell membrane
May act at junctions between the membrane and the cytoskeleton. Possesses tyrosine phosphatase activity
Cell membraneCytoplasm, cytoskeleton
Medicamentos e terapias
Mecanismo: Fibroblast growth factor receptor inhibitor
Mecanismo: Fibroblast growth factor receptor inhibitor
Mecanismo: Fibroblast growth factor receptor 2 inhibitor
Mecanismo: Vascular endothelial growth factor receptor inhibitor
Mecanismo: Dihydropyrimidine dehydrogenase inhibitor
Mecanismo: Fibroblast growth factor receptor inhibitor
Mecanismo: Thymidylate synthase inhibitor
Mecanismo: Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor
Mecanismo: Programmed cell death protein 1 inhibitor
Mecanismo: DNA polymerase (alpha/delta/epsilon) inhibitor
Variantes genéticas (ClinVar)
18,727 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
36 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Carcinoma da vesícula biliar
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Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
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Pancreaticobiliary maljunction (PBM) is a congenital anomaly in which the pancreatic and bile ducts join outside the duodenal wall.1,2 Reflux of pancreatic juice induces chronic inflammation and epithelial regeneration, promoting carcinogenesis. Biliary dilation increases the risk of cholangiocarcinoma, and prophylactic resection of the extrahepatic bile duct and gallbladder is recommended even for asymptomatic patients.3,4 To prevent postoperative carcinogenesis, the intrapancreatic bile duct should be transected just above the pancreatobiliary junction. The authors describe a novel dorsal approach to the pancreatic head using the retroperitoneal-first laparoscopic approach (Retlap).5-7 METHODS: A 73-year-old woman under follow-up evaluation for choledocholithiasis-associated cholangitis was found to have a gallbladder tumor. Evaluation showed PBM with biliary dilation. Computed tomography exhibited wall-thickening of the gallbladder fundus. Magnetic resonance cholangiopancreatography demonstrated a common bile duct diameter of 13 mm and a common channel length of 12 mm, whereas endoscopic retrograde cholangiopancreatography measured both as 15 mm. Biliary amylase was elevated. The preoperative diagnosis was gallbladder carcinoma with PBM and biliary dilation. After an explanation of the procedure and her informed consent, the woman underwent extrahepatic bile duct and gallbladder resection with lymphadenectomy using Retlap. The operative time was 480 min, including 210 min for Retlap, with 40 mL blood loss. The postoperative course was uneventful, and she was discharged on postoperative day 14. Pathology confirmed gallbladder carcinoma with single-node metastasis. At this writing, after adjuvant chemotherapy, the woman has remained recurrence-free 3 years. Although additional trocars and steps are required, Retlap for PBM may enable safe bile duct transection just above the pancreatobiliary junction and facilitate lymphadenectomy, providing excellent visualization and stable maneuverability.
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The sphincter of Oddi (SO), as the critical bidirectional regulatory valve structure of the pancreatobiliary system, still requires extensive research regarding its functional assessment and dysfunction repair. This systematic review examines SO regulatory mechanisms, diagnostic approaches for dysfunction, and repair strategies. Studies have demonstrated that SO myoelectrical activity is regulated by neural, humoral, and neurohumoral mechanisms, although the specific pathways involved remain incompletely understood. SO motility features both tonic and phasic contractions, with abnormalities closely linked to pancreatobiliary diseases. Pancreaticobiliary maljunction (PBM) or congenital SO anomalies may induce reciprocal reflux of pancreatobiliary secretions, thereby elevating the risk of biliary tract carcinogenesis, particularly cholangiocarcinoma and gallbladder carcinoma. While invasive SO manometry (SOM) remains the diagnostic gold standard for sphincter of Oddi dysfunction (SOD), noninvasive techniques such as quantitative hepatobiliary scintigraphy (QHBS) and secretin-stimulated magnetic resonance cholangiopancreatography (ss-MRCP) show promising clinical applicability. Current therapeutic options for SOD include endoscopic sphincterotomy (EST), endoscopic endoclip papilloplasty (EEPP), endoscopic papillary balloon dilation (EPBD), and transduodenal sphincteroplasty. In the precision medicine era, developing standardized noninvasive assessment tools and quantifiable, controllable, and visualizable methodologies for SO structure and function is imperative to achieve a precise understanding of its physiological and pathological states, ultimately maximizing patient outcomes in SO-related disorders.
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In recent years, the therapeutic scenario of metastatic biliary tract cancers (BTCs) beyond first-line has profoundly changed owing to target therapies. human epidermal growth factor receptor-2 (HER2) represents a promising molecular target that is frequently altered in BTC. The present meta-analyses aimed to describe the response rates and survival outcomes in patients with HER2-positive locally advanced/metastatic BTC treated with anti-HER2 therapies. Moreover, the study is intended to provide an update on the evolving therapeutic scenario of HER2-overexpressed BTC. We performed a systematic review of the literature to identify clinical trials investigating any regimen comprising a HER2-targeted therapy for metastatic BTC, and we conducted three subsequent meta-analyses on second-line phase II trials. The first one was performed to compare the group of HER2 3+ versus the group of HER2 2+ BTC patients for objective response rate (ORR). The second one compared patients according to the tumor location (gallbladder carcinoma [GBC] or extrahepatic cholangiocarcinoma [eCCA] versus intrahepatic cholangiocarcinoma [iCCA]) for ORR. The third one evaluated the overall outcomes in terms of overall survival (OS) and progression-free survival (PFS). Patients with advanced BTC and HER2 3+ had better ORR compared to HER2 2+, with a 3.7-fold higher probability of experiencing objective responses (HR 3.70, 95% CI, 1.34-10.25, p = 0.0119). Likewise, patients with GBC or eCCA had a 2.74-fold higher probability of experiencing an objective response compared to patients with iCCA (HR 2.74, 95% CI, 1.12-6.73, p = 0.0275). The weighted pooled analysis of trials with anti-HER2 agents in second line or beyond revealed an mPFS of 4.9 months (95% CI, 4.2-5.6), while mOS was 10.8 months (95% CI, 9.0-12.8). Our meta-analyses have revealed improved efficacy in patients with HER2 3+ metastatic BTC and in patients with GBC or eCCA treated with anti-HER2 therapies, with a considerable mPFS and mOS in the overall population of the phase II trials analyzed. Further studies are paramount to confirm our preliminary results.
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The lancet. Gastroenterology & hepatologyReal-world outcomes among patients with advanced or metastatic biliary tract cancers initiating second-line treatment.
Cancer medicineClinical Implications of BRCA Mutations in Advanced Biliary Tract Cancer.
OncologyAlbumin, filamin-A and cytokeratin 19 help distinguish intrahepatic cholangiocarcinoma from extrahepatic adenocarcinoma.
Hepatology internationalPersonal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers.
International journal of cancerSynchronous Multifocal Gall Bladder Cancer and Extrahepatic Cholangiocarcinoma.
Journal of gastrointestinal cancerThe epidemiology of rare types of hepatobiliary and pancreatic cancer from national cancer registry.
Journal of gastroenterologyComprehensive germline and somatic genomic profiles of Chinese patients with biliary tract cancer.
Frontiers in oncologyLenvatinib Plus Programmed Cell Death Protein-1 Inhibitor Beyond First-Line Systemic Therapy in Refractory Advanced Biliary Tract Cancer: A Real-World Retrospective Study in China.
Frontiers in immunologyImaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Radiographics : a review publication of the Radiological Society of North America, IncCurrent Targeted Therapy Options in the Treatment of Cholangiocarcinoma: A Literature Review.
CureusN-Cadherin Distinguishes Intrahepatic Cholangiocarcinoma from Liver Metastases of Ductal Adenocarcinoma of the Pancreas.
CancersChanging Epidemiological Trends of Hepatobiliary Carcinomas in Austria 2010-2018.
CancersThe clinical and prognostic factors for biliary neuroendocrine neoplasm: a study based on the SEER database.
BMC surgeryCholangiocarcinoma Attributed to Occupation: A Systematic Reviews.
Asian Pacific journal of cancer prevention : APJCPStatins associate with lower risk of biliary tract cancers: A systematic review and meta-analysis.
Cancer medicineLaparoscopic hepatopancreaticoduodenectomy for synchronous gallbladder cancer and extrahepatic cholangiocarcinoma: a case report.
World journal of surgical oncologyClinical, Genomic, and Transcriptomic Data Profiling of Biliary Tract Cancer Reveals Subtype-Specific Immune Signatures.
JCO precision oncologyCell-Free Tumor DNA Dominant Clone Allele Frequency Is Associated With Poor Outcomes in Advanced Biliary Cancers Treated With Platinum-Based Chemotherapy.
JCO precision oncologyWorldwide Incidence and Mortality of Biliary Tract Cancer.
Gastro hep advancesTargeted Therapies for Perihilar Cholangiocarcinoma.
CancersPolypoid invasive carcinoma of bile duct: report of four cases.
Clinical journal of gastroenterologyPhase II Study of Ramucirumab in Advanced Biliary Tract Cancer Previously Treated By Gemcitabine-Based Chemotherapy.
Clinical cancer research : an official journal of the American Association for Cancer ResearchPrognostic impact of FGFR2/3 alterations in patients with biliary tract cancers receiving systemic chemotherapy: the BITCOIN study.
European journal of cancer (Oxford, England : 1990)Association of annexin A10 expression with poor prognosis of intrahepatic cholangiocarcinoma.
BMC cancerLong-term incidence and survival trends in cancer of the gallbladder and extrahepatic bile ducts in Denmark, Finland, Norway and Sweden with etiological implications related to Thorotrast.
International journal of cancerChemoresistance and resistance to targeted therapies in biliary tract cancer: what have we learned?
Expert opinion on investigational drugsNanoliposomal irinotecan in combination with leucovorin and 5-fluorouracil in advanced biliary tract cancers.
Molecular and clinical oncology[A Case of Preoperatively Diagnosed Early Cystic-Duct Carcinoma].
Gan to kagaku ryoho. Cancer & chemotherapyLocally advanced gallbladder cancer treated with effective chemotherapy and subsequent curative resection: a case report.
Journal of medical case reportsSmall Cell Carcinoma of Gallbladder With Nodal Metastasis Mimicking As Synchronous Malignancy in Gallbladder and Common Bile Duct.
CureusThe role of extra-hepatic bile duct resection in the surgical management of gallbladder carcinoma. A first meta-analysis.
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical OncologyDual HER2 Blockade: An Emerging Option in Metastatic Biliary Tract Cancer?
Medicina (Kaunas, Lithuania)Third-line chemotherapy in advanced biliary cancers (ABC): pattern of care, treatment outcome and prognostic factors from a multicenter study.
Expert review of gastroenterology & hepatology[Gallbladder carcinoma and extrahepatic cholangiocarcinoma].
Therapeutische Umschau. Revue therapeutiqueMenopausal hormone therapy and risk of biliary tract cancers.
Hepatology (Baltimore, Md.)Management of Primary Hepatopancreatobiliary and Ampulla Large Cell Neuroendocrine Carcinoma.
Journal of laparoendoscopic & advanced surgical techniques. Part AEstablishment and drug screening of patient-derived extrahepatic biliary tract carcinoma organoids.
Cancer cell internationalApproach to Resectable Biliary Cancers.
Current treatment options in oncologyLevels of Circulating PD-L1 Are Decreased in Patients with Resectable Cholangiocarcinoma.
International journal of molecular sciencesClinicopathological Significance of Syndecan-1 in Cholangiocarcinoma: A Study Based on Immunohistochemistry and Public Sequencing Data.
Journal of clinical medicineKey Imaging Findings for the Prospective Diagnosis of Rare Diseases of the Gallbladder and Cystic Duct.
Korean journal of radiologyHepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Journal of the National Comprehensive Cancer Network : JNCCNAssociation Between Proton Pump Inhibitor Use and Biliary Tract Cancer Risk: A Swedish Population-Based Cohort Study.
Hepatology (Baltimore, Md.)Postdiagnosis Aspirin Use Associated With Decreased Biliary Tract Cancer-Specific Mortality in a Large Nationwide Cohort.
Hepatology (Baltimore, Md.)Trends in the Mortality of Biliary Tract Cancers Based on Their Anatomical Site in the United States From 2009 to 2018.
The American journal of gastroenterology[Squamous cell carcinoma of the gallbladder complicating a cystic dilation of the cystic duct and common bile duct: a case report].
The Pan African medical journalDietary intake of advanced glycation endproducts and risk of hepatobiliary cancers: A multinational cohort study.
International journal of cancerMolecular Characterization of Biliary Tract Cancer Predicts Chemotherapy and Programmed Death 1/Programmed Death-Ligand 1 Blockade Responses.
Hepatology (Baltimore, Md.)Bile Microbiota in Patients with Pigment Common Bile Duct Stones.
Journal of Korean medical science[A case of simultaneous multicentric cancer in the gallbladder duct and the common bile duct without pancreaticobiliary maljunction].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterologyEffect of endoscopic radiofrequency ablation on the survival of patients with inoperable malignant biliary strictures: A large cohort study.
Journal of hepato-biliary-pancreatic sciencesComparison of Inflammation-based Prognostic Scores in Patients With Biliary Tract Cancer After Surgical Resection.
Anticancer researchNeoadjuvant therapy for cholangiocarcinoma: A comprehensive literature review.
Cancer treatment and research communicationsMutational spectrum and precision oncology for biliary tract carcinoma.
TheranosticsProgrammed Death Ligand 1 Expression as a Prognostic Marker in Patients with Advanced Biliary Tract Cancer.
OncologyTenascin-W Is a Novel Stromal Marker in Biliary Tract Cancers.
Frontiers in immunologyCell of origin in biliary tract cancers and clinical implications.
JHEP reports : innovation in hepatologyPromising Molecular Targets for the Targeted Therapy of Biliary Tract Cancers: An Overview.
OncoTargets and therapyPembrolizumab-induced large duct cholangiopathy: Diagnosis and follow.up imaging.
Journal of postgraduate medicineAdenomyomatous hyperplasia of the extrahepatic bile duct: a systematic review of a rare lesion mimicking bile duct carcinoma.
Clinical journal of gastroenterologyTargeting BRAF-Mutant Biliary Tract Cancer: Recent Advances and Future Challenges.
Cancer control : journal of the Moffitt Cancer CenterSecond-line Chemotherapy Prolongs Survival in Real World Patients With Advanced Biliary Tract and Gallbladder Cancers: A Multicenter Retrospective Population-based Cohort Study.
American journal of clinical oncologyExperience With Anti-PD-1 Antibody, Camrelizumab, Monotherapy for Biliary Tract Cancer Patients and Literature Review.
Technology in cancer research & treatmentGallbladder Carcinoma Accompanied by Pancreaticobiliary Maljunction With a Rare Double Common Bile Duct.
The American journal of gastroenterologyA Perspective on Cell Therapy and Cancer Vaccine in Biliary Tract Cancers (BTCs).
CancersPancreatobiliary Maljunction-associated Gallbladder Cancer Is as Common in the West, Shows Distinct Clinicopathologic Characteristics and Offers an Invaluable Model for Anatomy-induced Reflux-associated Physio-chemical Carcinogenesis.
Annals of surgeryOncogenic KRAS-expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice.
Cancer sciencePuzzle and Challenge in Routine Extrahepatic Bile Duct Resection for Advanced Gallbladder Carcinoma.
Gut and liverFutibatinib, an investigational agent for the treatment of intrahepatic cholangiocarcinoma: evidence to date and future perspectives.
Expert opinion on investigational drugsA case of gallbladder adenocarcinoma arising in association with intracystic papillary neoplasm (ICPN) with abundant mucin production.
Clinical journal of gastroenterologyPancreaticoduodenectomy in a patient with intestinal malrotation and distal cholangiocarcinoma: a case report and review of the literature.
Journal of medical case reportsRNA Sequencing of Hepatobiliary Cancer Cell Lines: Data and Applications to Mutational and Transcriptomic Profiling.
CancersMolecular Profiling in Daily Clinical Practice: Practicalities in Advanced Cholangiocarcinoma and Other Biliary Tract Cancers.
Journal of clinical medicineDetails of human epidermal growth factor receptor 2 status in 454 cases of biliary tract cancer.
Human pathologyA prospective feasibility study of one-year administration of adjuvant S-1 therapy for resected biliary tract cancer in a multi-institutional trial (Tokyo Study Group for Biliary Cancer: TOSBIC01).
BMC cancerAdeno-squamous and squamous cell carcinoma of the gallbladder: The importance of histology in surgical management.
American journal of surgeryA case of mixed neuroendocrine non-neuroendocrine neoplasm of the distal bile duct with biliary intraepithelial neoplasia.
Clinical journal of gastroenterologyClinicopathological Characteristics and Surgical Outcomes of Primary Cystic Duct Carcinoma: A Multi-institutional Study.
World journal of surgeryMolecular profile of BRCA-mutated biliary tract cancers.
ESMO open[Systemic Chemotherapy of gallbladder carcinoma - simply the same as for cholangiocarcinoma?].
Zeitschrift fur GastroenterologieStereotactic body radiotherapy in the management of oligometastatic and recurrent biliary tract cancer: single-institution analysis of outcome and toxicity.
Journal of cancer research and clinical oncologyEndoscopic revision efficacy after clinically successful bilateral metal stenting for advanced malignant hilar obstruction.
Journal of gastroenterology and hepatologyRegorafenib after failure of gemcitabine and platinum-based chemotherapy for locally advanced/metastatic biliary tumors: REACHIN, a randomized, double-blind, phase II trial.
Annals of oncology : official journal of the European Society for Medical OncologyTesting for ROS1, ALK, MET, and HER2 rearrangements and amplifications in a large series of biliary tract adenocarcinomas.
Virchows Archiv : an international journal of pathologyLandmark survival analysis and impact of anatomic site of origin in prospective clinical trials of biliary tract cancer.
Journal of hepatologyCore Hippo pathway components act as a brake on Yap and Taz in the development and maintenance of the biliary network.
Development (Cambridge, England)Postoperative infectious complications caused by multidrug-resistant pathogens in patients undergoing major hepatectomy with extrahepatic bile duct resection.
SurgeryType Vb duplication of the extrahepatic bile duct in a patient with gallbladder cancer.
Asian journal of surgery[Biliary tract cancer: on the way to a personalized therapy].
Deutsche medizinische Wochenschrift (1946)Hepatobiliary cancers and immunotherapy: where are we now and where are we heading?
Translational gastroenterology and hepatologyGermline alterations in patients with biliary tract cancers: A spectrum of significant and previously underappreciated findings.
CancerPalliative Measures with Ethanol Gallbladder Ablation and Endobiliary Radiofrequency Ablation Followed by Endoscopic Biliary Stent Placement in an Advanced Case of Common Bile Duct Cancer: A Case Report.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chiSurvival improvement and prognostic factors in recent management of extrahepatic cholangiocarcinoma: A single-center study.
Hepatobiliary & pancreatic diseases international : HBPD INTGallbladder and extrahepatic bile duct cancers in the Americas: Incidence and mortality patterns and trends.
International journal of cancerType VI choledochal cyst with gall bladder carcinoma.
BMJ case reportsLandscape of distant metastasis mode and current chemotherapy efficacy of the advanced biliary tract cancer in the United States, 2010-2016.
Cancer medicineGenetically engineered animal models of biliary tract cancers.
Current opinion in gastroenterologyCystic duct cancer: Should it be deemed as a type of gallbladder cancer?
World journal of gastroenterologyEarly-stage T1b adenocarcinoma arising in the remnant cystic duct after laparoscopic cholecystectomy: a case report and literature review.
BMC surgeryClinicopathologic and Prognostic Significance of Gallbladder and Cystic Duct Invasion in Distal Bile Duct Carcinoma.
Archives of pathology & laboratory medicineA case of small in situ perihilar cholangiocarcinoma incidentally accompanied by benign bile duct stricture after open cholecystectomy.
Surgical case reportsAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Isolated Neurofibroma of the Gallbladder and Common Bile Duct Mimicking Malignancy: A Rare Case Report and Review of Literature.
- Retroperitoneal-First Laparoscopic Approach (Retlap) for Bile Duct Resection in Pancreaticobiliary Maljunction (PBM): A Novel and Reasonable Approach to Intrapancreatic Bile Duct.
- Function Regulation Assessment and Pathophysiological Dysfunction Repair of Oddi Sphincter.
- Molecular Testing for Intrahepatic Cholangiocarcinoma: What, When, How?
- Anti-Human Epidermal Growth Factor Receptor-2 Therapies in Biliary Tract Cancers: A Meta-Analysis on Disease Location, Human Epidermal Growth Factor Receptor-2 Status, and Survival Outcomes.
- A Study on Gallbladder Carcinoma With Special Reference to Risk Factors.
- Mixed adenoneuroendocrine carcinoma of the gallbladder: a case report and review of the literature.
- Squamous Cell Carcinoma of the Gallbladder Presenting as Recurrent Hepatic Abscess: A Case Report.
- Squamous Cell Carcinoma of the Gallbladder With Recurrence at the Tumor Spillage Site Following Laparoscopic Cholecystectomy.
- Synchronous primary gallbladder squamous cell carcinoma and colon adenocarcinoma: A case report and literature review.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:56044(Orphanet)
- MONDO:0018918(MONDO)
- GARD:18850(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q56014224(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
