Raras
Buscar doenças, sintomas, genes...
Síndrome Morvan
ORPHA:83467CID-10 · G60.8CID-11 · 8E4A.3DOENÇA RARA

A síndrome de Morvan é uma doença neurológica adquirida rara, com risco de vida, caracterizada por neuromiotonia, disautonomia e encefalopatia com insônia grave. Sinais envolvendo hiperatividade central (por exemplo, alucinações, confusão, amnésia, mioclonia), autonômica (por exemplo, variações na pressão arterial, hiperidrose) e periférica (por exemplo, cólicas dolorosas, mioquimia), bem como manifestações sistêmicas (como perda de peso, prurido, febre). O timoma está presente em alguns casos.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

A síndrome de Morvan é uma doença neurológica adquirida rara, com risco de vida, caracterizada por neuromiotonia, disautonomia e encefalopatia com insônia grave. Sinais envolvendo hiperatividade central (por exemplo, alucinações, confusão, amnésia, mioclonia), autonômica (por exemplo, variações na pressão arterial, hiperidrose) e periférica (por exemplo, cólicas dolorosas, mioquimia), bem como manifestações sistêmicas (como perda de peso, prurido, febre). O timoma está presente em alguns casos.

Publicações científicas
142 artigos
Último publicado: 2026 Mar 19

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Worldwide
Casos conhecidos
60
pacientes catalogados
Início
Adult
🏥
SUS: Cobertura mínimaScore: 15%
CID-10: G60.8
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Características mais comuns

55%prev.
Anti-CASPR2
Frequente (79-30%)
1sintomas
Frequente (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 1 características clínicas mais associadas, ordenadas por frequência.

Anti-CASPR2
Frequente (79-30%)55%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico142PubMed
Últimos 10 anos113publicações
Pico202215 papers
Linha do tempo
2026Hoje · 2026🧪 2014Primeiro ensaio clínico📈 2022Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndrome Morvan

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Pesquisa e ensaios clínicos

Nenhum ensaio clínico registrado para esta condição.

🧪 Está conduzindo uma pesquisa?
Divulgue para pacientes e familiares que acompanham esta doença.
Divulgar pesquisa →

Publicações mais relevantes

Timeline de publicações
114 papers (10 anos)
#1

Morvan syndrome in a patient with progressing metastatic thymoma and myasthenia gravis.

BMJ case reports2026 Mar 19

Morvan syndrome (MoS) is a rare paraneoplastic syndrome that is predominantly characterised by autonomic dysfunction, peripheral nerve hyperexcitability and altered mental status. Cases in literature often describe pre-existing autoimmune diagnoses in patients with MoS, alluding to its association with systemic immune dysregulation.We report a woman presenting with hypersomnolence and fluctuating mental status consistent with MoS who had been previously diagnosed with metastatic thymoma, acetylcholine receptor-positive myasthenia gravis and multiple other chronic medical conditions. The report emphasises the importance of prompt recognition of symptoms and accurate diagnosis in rare diseases, allowing for timely initiation of the appropriate immunotherapy that ultimately led to rapid and significant clinical improvement.

#2

CASPR2 antibody-related neurological syndromes in children: three cases report and literature review.

BMC pediatrics2026 Feb 05

Contactin-associated protein-like 2 (CASPR2) antibody-related neurological syndrome is well defined in adults, while data in children is rare. We perform this case series and literature review to ascertain the clinical features of this disorder in children. We describe three cases who were diagnosed with CASPR2 antibody-related neurological syndrome, and then systematically characterized clinical features, therapeutic responses, and outcomes in 64 patients in literature. Among the 67 patients, the median age was 8.4 years (range 0.5–18), with a male predominance (65.7%). The most characteristic symptoms of CASPR2 antibody-related neurological syndrome include psychiatric abnormalities (68.7%), sleep disorders (55.2%), dysautonomia (44.8%), movement disorders (43.3%), seizures (41.8%), neuropathic pain (34.3%), and cognitive disturbances (31.3%). Autoimmune encephalitis (AE, 62.7%) was most frequent, followed by Morvan syndrome (MoS, 26.9%) and peripheral nerve hyperexcitability (PNH, 7.5%). CASPR2 antibodies are typically detected in serum (85.1%), but rarely in CSF exclusively (3.0%). Investigations revealed abnormalities in CSF analysis (22.9%; 13 AE, 5 MoS), brain MRI (24.1%; 11 AE, 3 MoS), and EEG (67.3%; 26 AE, 7 MoS). Neoplasm was not found in our case series and literature review. Regarding treatment, 46 patients received first-line immunotherapy alone, while 5 required second-line treatment. Immunotherapy demonstrated highly effective, with 95.8% achieving a favorable outcome (mRS score ≤ 2) and a low recurrence rate of 5.1%. We therefore recommend that all children presenting with new-onset psychiatric abnormalities, sleep disorders, dysautonomia, movement disorders, seizures, neuropathic pain, and cognitive disturbances should be suspected of having CASPR2 antibody-related neurological syndrome. Neoplastic processes are rare in pediatric patients. Early recognition of the disease is important because it responds well to immunotherapy. The online version contains supplementary material available at 10.1186/s12887-026-06549-4.

#3

Morvan Syndrome Masquerading as Anxiety Disorder: A Case Report Highlighting the Importance of Recognizing Organic Signs in Psychiatric Settings.

International medical case reports journal2026

Morvan syndrome is a rare subtype of autoimmune encephalitis, primarily characterized by increased peripheral nerve excitability, autonomic dysfunction, and severe insomnia. This report presents a 28-year-old female patient who sought medical attention due to widespread pain, refractory insomnia, limb sensory abnormalities, and low mood, initially diagnosed as "anxiety disorder". Neurological examination revealed muscle twitching in the limbs. Electromyography indicated increased peripheral nerve excitability, with serum testing showing weak positivity for anti-Leucine-rich Glioma Inactivated 1 (LGI-1) IgG antibodies and strong positivity for anti-Contactin-associated Protein-like 2 (CASPR2) IgG antibodies. Cerebrospinal fluid Pandy's test was weakly positive. The final diagnosis was Morvan syndrome complicated by anxiety disorder. Following treatment, the patient's symptoms significantly improved. This case highlights the diagnostic challenges of Morvan syndrome, particularly when patients present with prominent psychiatric symptoms that mimic functional disorders. It underscores the critical importance of screening for subtle organic signs-specifically fasciculations and widespread pain-in patients with refractory anxiety to prevent misdiagnosis and facilitate timely immunotherapy.

#4

Morvan syndrome associated with prominent Tau pathology: A clinicopathological case report.

Journal of neuroimmunology2026 Feb 27

We report a case of Morvan syndrome in a 48-year-old man, emphasizing the presence of prominent tau pathology in the frontal cortex identified during postmortem examination. Morvan syndrome is characterized by peripheral nerve hyperexcitability, autonomic dysfunction, and encephalopathy, and is often associated with antibodies against LGI1 and Caspr2. Clinical assessment documented neurological, autonomic, and cognitive symptoms consistent with Morvan syndrome. Serological testing confirmed LGI1 and Caspr2 antibodies. Despite treatment, the patient suffered fatal cardiac arrest. Full autopsy, including detailed neuropathological assessment, was performed, with specific examination of neuronal and glial tau pathology. Autopsy revealed a thymoma and extensive tau accumulation in the frontal cortex with neuronal and astrocytic involvement. Neurofibrillary tangles, pretangles, and astroglial tau aggregates were detected. The patient had no history of repetitive head trauma or participation in contact sports. This case suggests a potential association between immune-mediated disorders-specifically Morvan syndrome with LGI1 and Caspr2 antibodies-and focal tau pathology. The coexistence of autoimmune features and tau deposition raises questions about shared or interacting pathophysiological mechanisms. Further research is warranted to clarify these relationships.

#5

A rare presentation of CASPR2-associated Morvan syndrome overlapping with GM1-positive AMSAN: a case report.

Frontiers in immunology2026

Morvan syndrome is a rare autoimmune disorder characterized by peripheral nerve hyperexcitability with autonomic and central nervous system involvement, most commonly associated with antibodies against contactin-associated protein-like 2 (CASPR2). Acute motor and sensory axonal neuropathy (AMSAN) is an axonal variant of Guillain-Barré syndrome linked to anti-ganglioside antibodies and often manifests as severe limb weakness. Their concurrent presentation is unusual and raises the possibility of shared immune targets within peripheral nerve microdomains. A 70-year-old man presented with a relapsing course of progressive lower-limb weakness accompanied by widespread muscle twitching, severe insomnia with nocturnal hyperarousal, and refractory constipation. He had a prior episode diagnosed as AMSAN that improved after immunotherapy but relapsed four months after treatment was discontinued. Neurological examination demonstrated bilateral lower-limb weakness with reduced tendon reflexes. Moreover, electrophysiological studies confirmed diffuse multifocal peripheral nerve injury with superimposed peripheral nerve hyperexcitability. In addition, immunologic testing revealed serum anti-GM1 antibodies and anti-CASPR2 IgG in both serum and cerebrospinal fluid. Collectively, these findings supported a diagnosis of recurrent AMSAN coexisting with CASPR2-associated Morvan syndrome. Combined immunotherapy with corticosteroids and intravenous immunoglobulin, alongside symptomatic management, resulted in marked clinical improvement. This case report describes a rare overlap of relapsing AMSAN and Morvan syndrome. This antibody-defined coexistence is hypothesis-generating and may reflect synergistic immune injury involving nodal and paranodal regions. This case underscores the importance of recognizing overlapping phenotypes to guide diagnostic profiling and immunomodulatory therapy.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC71 artigos no totalmostrando 111

2026

Morvan syndrome in a patient with progressing metastatic thymoma and myasthenia gravis.

BMJ case reports
2026

Morvan Syndrome Masquerading as Anxiety Disorder: A Case Report Highlighting the Importance of Recognizing Organic Signs in Psychiatric Settings.

International medical case reports journal
2026

Morvan syndrome associated with prominent Tau pathology: A clinicopathological case report.

Journal of neuroimmunology
2026

A rare presentation of CASPR2-associated Morvan syndrome overlapping with GM1-positive AMSAN: a case report.

Frontiers in immunology
2026

A Rare Adolescent Presentation of Morvan Syndrome: Diagnostic Challenges and Therapeutic Response.

Clinical case reports
2026

CASPR2 antibody-related neurological syndromes in children: three cases report and literature review.

BMC pediatrics
2026

Video-Polysomnography in Peripheral Nerve Hyperexcitability: Clues to Morvan Syndrome in Two Patients and Literature Review.

Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society
2025

Thymectomy for Morvan Syndrome Associated With Thymoma.

Annals of thoracic surgery short reports
2025

A Rare Case Report of Morvan Syndrome: A Constellation of Autonomic, Central and Peripheral Nervous System Involvement.

Cureus
2025

Glutamic Acid Decarboxylase Antibody Unexpectedly Detected During Recovery Phase in Three Patients With Voltage-Gated Potassium Channel Antibody-Related Autoimmune Encephalitis.

Cureus
2025

Dual diagnosis at the neuro-immune interface: a case report of neuronal intranuclear inclusion disease with acute anti-CASPR2 encephalitis.

Frontiers in immunology
2025

Neuropathic pain in CASPR2 antibody disease spectrum: A systematic review.

Journal of neuroimmunology
2025

Morvan syndrome with bilateral basal ganglia hyperintensities and exfoliative skin rashes in a patient with Chronic Hepatitis B: A diagnostic and therapeutic dilemma.

Clinical neurology and neurosurgery
2025

Anesthetic Management of a Patient with Morvan Syndrome.

Journal of cardiothoracic and vascular anesthesia
2025

Electroencephalography and polysomnography as predictors of long-term functional outcomes in anti-CASPR2 encephalitis: A multicenter cohort study.

Epileptic disorders : international epilepsy journal with videotape
2025

Autoimmune encephalitis with CASPR2 antibody: A case series and updated literature review.

International immunopharmacology
2025

Unmasking Anti-CASPR2 Syndrome in a Patient Treated for Myasthenia Gravis in the Era of New Treatments.

European journal of neurology
2025

Exploring Telitacicept for Neurological Autoimmune Disorders: A Case Study on Morvan Syndrome.

The American journal of case reports
2025

Successful treatment of morvan syndrome with efgartigimod: report of two cases.

Journal of neurology
2025

Leucine-rich glioma-inactivated protein 1 antibody-positive limbic encephalitis in a patient with an early-stage asymptomatic breast cancer.

BMJ case reports
2024

A case series: Three cases of Morvan's syndrome as a rare autoimmune disorder with anti-Caspr2 antibody.

Medicine
2024

A Case Report of an Atypical Presentation of Morvan Syndrome.

Cureus
2024

A rare case of LGI1 antibody-positive Morvan syndrome with myasthenia gravis.

Medicina clinica
2024

The neurobiology and immunology of CASPR2-associated neurological disorders.

Revue neurologique
2024

Characteristics of after-discharges following compound muscle action potential or F-wave in primary peripheral nerve hyperexcitability syndrome.

Muscle &amp; nerve
2024

Morvan Fibrillary Chorea Associated with Monoclonal B Cell Lymphocytosis.

The American journal of case reports
2024

Anesthetic Management of Patients With Morvan Syndrome: A Case Report and Literature Review.

Cureus
2024

Paraneoplastic autoimmune neurologic disorders associated with thymoma.

Handbook of clinical neurology
2024

Morvan Syndrome Associated With Anti-LGI1 Antibodies and Thymoma.

Journal of clinical neurology (Seoul, Korea)
2024

Autonomic nervous system involvement in autoimmune encephalitis and paraneoplastic neurological syndromes.

Revue neurologique
2023

Occult bowel cancer presenting as Morvan syndrome.

BMJ case reports
2023

Distinct phenotypes in a cohort of anti-CASPR2 associated neurological syndromes.

Clinical neurology and neurosurgery
2023

Motor symptoms in nonparaneoplastic CNS disorders associated with neural antibodies.

Handbook of clinical neurology
2023

Anesthetic management of patients with Morvan syndrome - A rare disorder.

Saudi journal of anaesthesia
2023

Clinical features of 28 cases of anti-leucine-rich glioma-inactivated protein 1 encephalitis and anti-contactin-associated protein-like 2 encephalitis.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
2023

Contactin-Associated Protein-Like 2-Related Peripheral Nerve Hyperexcitability Associated With Charcot-Marie-Tooth Type 4F.

The Neurohospitalist
2022

Morvan's syndrome: An unusual presentation of a solid pseudopapillary pancreatic tumor.

Journal of neurosciences in rural practice
2022

A Case of Anti-Caspr2 Autoimmune Encephalitis Associated with Adenocarcinoma of the Lung.

European journal of case reports in internal medicine
2022

Autoimmune neuromyotonia.

Current opinion in neurology
2022

Morvan Syndrome Manifesting as Autoimmune Paraneoplastic Encephalitis Associated with Thymoma and Antivoltage Gated Potassium Channel (Leucine Rich, Glioma Inactivated 1) Antibody Detected using F 18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.

Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, India
2022

[Morvan syndrome associated with unresectable thymoma responsive to chemotherapy: a case report].

Rinsho shinkeigaku = Clinical neurology
2022

Guillain-Barré-like syndrome: an uncommon feature of CASPR2 and LGI1 autoimmunity.

Journal of neurology
2022

Refractory Morvan syndrome responsive to rituximab: a case report and review of the literature.

Neuromuscular disorders : NMD
2022

Sleep Disorders and Autoimmunity: Insomnia as the Presenting Sign of Morvan Syndrome Associated with CASPR2 Antibodies.

Noro psikiyatri arsivi
2022

[Morvan syndrome with positive anti LGI1/CASPR2 antibodies in serum/cerebrospinal fluid:a case report and literature review].

Zhonghua nei ke za zhi
2022

Phenotypic Spectrum of CASPR2 and LGI1 Antibodies Associated Neurological Disorders in Children.

Frontiers in pediatrics
2023

Bilateral Panuveitis Associated with Morvan Syndrome: A Case Report and Review of the Literature.

Ocular immunology and inflammation
2022

Autoimmune Neurological Disorders with IgG4 Antibodies: a Distinct Disease Spectrum with Unique IgG4 Functions Responding to Anti-B Cell Therapies.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2022

Extrapleural pneumonectomy for recurrent thymoma diagnosed after return of paraneoplastic Morvan syndrome.

Journal of surgical case reports
2022

Objective sleep profile in LGI1/CASPR2 autoimmunity.

Sleep
2022

IgG4-Mediated Neurologic Autoimmunities: Understanding the Pathogenicity of IgG4, Ineffectiveness of IVIg, and Long-Lasting Benefits of Anti-B Cell Therapies.

Neurology(R) neuroimmunology &amp; neuroinflammation
2022

Morvan Syndrome Converted from Isaacs' Syndrome after Thymectomy with Positivity for Both Anti-LGI1 and Anti-CASPR2 Antibodies.

Internal medicine (Tokyo, Japan)
2021

Electrodiagnostic Assessment of Hyperexcitable Nerve Disorders.

Neurologic clinics
2021

CASPR2-Related Morvan Syndrome: Autonomic, Polysomnographic, and Neuropsychological Observations.

Neurology. Clinical practice
2021

A case report of Morvan syndrome.

Oxford medical case reports
2021

Clinical Profile and Treatment Response in Patients with CASPR2 Antibody-Associated Neurological Disease.

Annals of Indian Academy of Neurology
2021

Demystifying the spontaneous phenomena of motor hyperexcitability.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2021

Clinical Character of CASPR2 Autoimmune Encephalitis: A Multiple Center Retrospective Study.

Frontiers in immunology
2021

Pediatric LGI1 and CASPR2 autoimmunity associated with COVID 19: Morvan syndrome.

Journal of neurology
2021

Morvan syndrome associated with LGI1 antibody: a case report.

BMC neurology
2021

Total Wake: Natural, Pathological, and Experimental Limits to Sleep Reduction.

Frontiers in neuroscience
2021

Sleep Disturbances Associated with Neurological Autoimmunity.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics
2021

Anesthetic Management of Robotic Thymectomy in a Patient With Morvan Syndrome: A Case Report.

A&amp;A practice
2021

Caspr2 autoantibody-associated Morvan syndrome predating thymoma relapse by 30 months.

Lung cancer (Amsterdam, Netherlands)
2021

Morvan syndrome: case report.

Medicina clinica
2020

Clinical characteristics of patients double positive for CASPR2 and LGI1-antibodies.

Clinical neurology and neurosurgery
2020

Anti-CASPR2 clinical phenotypes correlate with HLA and immunological features.

Journal of neurology, neurosurgery, and psychiatry
2020

CASPR2 autoimmunity in children expanding to mild encephalopathy with hypertension.

Neurology
2020

Expanding clinical spectrum of Caspr2 antibody-associated disease: warning on brainstem involvement and respiratory failure.

Journal of the neurological sciences
2020

Morvan Syndrome and Diffuse Large B-Cell Lymphoma in the Central Nervous System.

The neurologist
2020

Mercury-induced autoimmunity: Report of two adolescent siblings with Morvan syndrome "plus" and review of the literature.

Journal of neuroimmunology
2020

Systematic review of the clinical spectrum of CASPR2 antibody syndrome.

Journal of neurology
2019

Insomnia and Dysautonomia with Contactin-Associated Protein 2 and Leucine-Rich Glioma Inactivated Protein 1 Antibodies: A "Forme Fruste" of Morvan Syndrome?

Case reports in neurology
2019

[Ectopic Hilar Thymoma Associated with Morvan Syndrome after Extended Thymectomy for Myasthenia Gravis].

Kyobu geka. The Japanese journal of thoracic surgery
2019

Successful therapeutic plasma exchange in a patient with Morvan syndrome.

Asian journal of transfusion science
2019

LGI1 and CASPR2 autoimmunity in children: Systematic literature review and report of a young girl with Morvan syndrome.

Journal of neuroimmunology
2019

Clinical characteristics of autoimmune disorders in the central nervous system associated with myasthenia gravis.

Journal of neurology
2019

Peripheral nerve hyperexcitability.

Handbook of clinical neurology
2019

Fatal familial insomnia and Agrypnia Excitata: Autonomic dysfunctions and pathophysiological implications.

Autonomic neuroscience : basic &amp; clinical
2018

Delayed onset of severe chronic pain in CASPR2 autoantibody-associated Morvan syndrome in a former UK swine abattoir worker.

Pain reports
2019

Admission diagnoses of patients later diagnosed with autoimmune encephalitis.

Journal of neurology
2018

Updates in the Diagnosis and Treatment of Paraneoplastic Neurologic Syndromes.

Current oncology reports
2018

Association of Leucine-Rich Glioma Inactivated Protein 1, Contactin-Associated Protein 2, and Contactin 2 Antibodies With Clinical Features and Patient-Reported Pain in Acquired Neuromyotonia.

JAMA neurology
2018

Michel Jouvet as a clinical neurophysiologist and neurologist.

Sleep medicine
2018

A Phase II Study of Pemetrexed in Patients with Recurrent Thymoma and Thymic Carcinoma.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer
2018

Morvan syndrome associated with CASPR2 and LGI1 antibodies in a child.

Neurology
2018

Functional Impairments in a Patient with Morvan Syndrome: A Case Presentation.

PM &amp; R : the journal of injury, function, and rehabilitation
2017

Peripheral Nerve Hyperexcitability Syndromes.

Continuum (Minneapolis, Minn.)
2017

Morvan syndrome: a rare cause of syndrome of inappropriate antidiuretic hormone secretion.

Clujul medical (1957)
2017

Autoimmune episodic ataxia in patients with anti-CASPR2 antibody-associated encephalitis.

Neurology(R) neuroimmunology &amp; neuroinflammation
2017

Morvan syndrome as a paraneoplastic disorder of thymoma with anti-CASPR2 antibodies.

Lancet (London, England)
2017

Netrin-1 receptor antibodies in thymoma-associated neuromyotonia with myasthenia gravis.

Neurology
2017

Fatal Morvan Syndrome Associated With Myasthenia Gravis.

The neurologist
2016

Clinical utility of seropositive voltage-gated potassium channel-complex antibody.

Neurology. Clinical practice
2017

Morvan syndrome with Caspr2 antibodies. Clinical and autopsy report.

Journal of the neurological sciences
2017

Anti-contactin-associated protein-2 encephalitis: relevance of antibody titres, presentation and outcome.

European journal of neurology
2017

Encephalopathy with upper body hypertonia and myoclonus in patient with systemic lupus erythematosus and anti-CASPR2.

Lupus
2016

Characterization of a Subtype of Autoimmune Encephalitis With Anti-Contactin-Associated Protein-like 2 Antibodies in the Cerebrospinal Fluid, Prominent Limbic Symptoms, and Seizures.

JAMA neurology
2016

The clinical spectrum of Caspr2 antibody-associated disease.

Neurology
2016

Morvan Syndrome Secondary to Thymic Carcinoma in a Patient with Systemic Lupus Erythematosus.

Case reports in neurological medicine
2016

A Case of Morvan Syndrome Mimicking Amyotrophic Lateral Sclerosis With Frontotemporal Dementia.

Journal of clinical neuromuscular disease
2016

Autoimmune sleep disorders.

Handbook of clinical neurology
2016

A Chinese female Morvan patient with LGI1 and CASPR2 antibodies: a case report.

BMC neurology
2016

A Case Series of Patients With Autoimmune Myasthenia Gravis in Association With Invasive Thymoma.

Journal of clinical neuromuscular disease
2016

Morvan Syndrome: A Case Report With Patient Narrative and Video.

The Neurohospitalist
2015

[Intravenous immunoglobulin therapy in Morvan syndrome secondary to recurrent thymic carcinoma].

Medwave
2016

Thymoma associated with autoimmune diseases: 85 cases and literature review.

Autoimmunity reviews
2015

Peripheral small fiber dysfunction and neuropathic pain in patients with Morvan syndrome.

Neurology
2015

Inhibitory axons are targeted in hippocampal cell culture by anti-Caspr2 autoantibodies associated with limbic encephalitis.

Frontiers in cellular neuroscience
2015

Status dissociatus and disturbed dreaming in a patient with Morvan syndrome plus myasthenia gravis.

Sleep medicine
2015

Immunotherapy of oneiric stupor in Morvan syndrome: Efficacy documented by actigraphy.

Neurology

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Síndrome Morvan.

É de uma associação que acompanha esta doença? Fale com a gente →

Comunidades

Grupos ativos de quem convive com esta doença aqui no Raras

Ainda não existe comunidade no Raras para Síndrome Morvan

Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.

Tire suas dúvidas

Perguntas, dicas e experiências compartilhadas aqui na página

Participe da discussão

Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.

Fazer login

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Morvan syndrome in a patient with progressing metastatic thymoma and myasthenia gravis.
    BMJ case reports· 2026· PMID 41856686mais citado
  2. CASPR2 antibody-related neurological syndromes in children: three cases report and literature review.
    BMC pediatrics· 2026· PMID 41645108mais citado
  3. Morvan Syndrome Masquerading as Anxiety Disorder: A Case Report Highlighting the Importance of Recognizing Organic Signs in Psychiatric Settings.
    International medical case reports journal· 2026· PMID 41800271mais citado
  4. Morvan syndrome associated with prominent Tau pathology: A clinicopathological case report.
    Journal of neuroimmunology· 2026· PMID 41793952mais citado
  5. A rare presentation of CASPR2-associated Morvan syndrome overlapping with GM1-positive AMSAN: a case report.
    Frontiers in immunology· 2026· PMID 41756294mais citado
  6. A Rare Adolescent Presentation of Morvan Syndrome: Diagnostic Challenges and Therapeutic Response.
    Clin Case Rep· 2026· PMID 41727746recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:83467(Orphanet)
  2. MONDO:0008718(MONDO)
  3. GARD:9766(GARD (NIH))
  4. Busca completa no PubMed(PubMed)
  5. Artigo Wikipedia(Wikipedia)
  6. Q2964544(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Síndrome Morvan
Compêndio · Raras BR

Síndrome Morvan

ORPHA:83467 · MONDO:0008718
Prevalência
<1 / 1 000 000
Casos
60 casos conhecidos
CID-10
G60.8 · Outras neuropatias hereditárias e idiopáticas
CID-11
Início
Adult
Prevalência
0.0 (Worldwide)
MedGen
UMLS
C0751540
EuropePMC
Wikidata
Wikipedia
Papers 10a
DiscussaoAtiva

Nenhuma novidade ainda. O agente esta monitorando.

0membros
0novidades