A amiloidose secundária é uma forma de amiloidose que complica doenças inflamatórias crônicas (principalmente artrite reumatóide) e é caracterizada pela agregação e deposição de fibrilas amilóides compostas de proteína amiloide A sérica, um reagente de fase aguda. Embora o baço, a glândula suprarrenal, o fígado e o intestino sejam locais frequentes de deposição de amiloide, o quadro clínico é dominado pelo envolvimento renal.
Introdução
O que você precisa saber de cara
A amiloidose secundária é uma forma de amiloidose que complica doenças inflamatórias crônicas (principalmente artrite reumatóide) e é caracterizada pela agregação e deposição de fibrilas amilóides compostas de proteína amiloide A sérica, um reagente de fase aguda. Embora o baço, a glândula suprarrenal, o fígado e o intestino sejam locais frequentes de deposição de amiloide, o quadro clínico é dominado pelo envolvimento renal.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 10 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 32 características clínicas mais associadas, ordenadas por frequência.
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
1 gene identificado com associação a esta condição. Padrão de herança: Not applicable.
Major acute phase protein
Secreted
Variantes genéticas (ClinVar)
16 variantes patogênicas registradas no ClinVar.
Vias biológicas (Reactome)
9 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Amiloidose AA
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 624
Canakinumab treatment in patients with colchicine-resistant familial mediterranean fever: a multicenter observational study.
Anti-interleukin-1 agents have known beneficial effects in the treatment of colchicine-resistant familial Mediterranean fever (cr-FMF); however, studies to date have tended to have small sample sizes and to be based on pooled data. The present study investigates the efficacy of Canakinumab (CAN) in a homogeneous cohort of cr-FMF cases. The study included patients who underwent treatment in three tertiary rheumatology departments, whose electronic medical records were reviewed retrospectively. The inclusion criteria were presence of colchicine resistant disease activity or persistent proteinuria secondary to AA-amyloidosis, and treatment with CAN for at least 6 months. Clinical and laboratory parameters were assessed before and after CAN treatment. The study included 65 patients with a mean age of 38.2 ± 13.8 years, with a mean disease duration of 23.7 ± 11.4 years and a mean colchicine dosage of 1.5 ± 0.6 mg/day. Of the total, 60% of the patients had an M694V homozygous mutation, and 41.5% were resistant to Anakinra. Furthermore, 25 had FMF-related amyloidosis, and 16 were renal transplant recipients. The mean CAN treatment duration was 31.3 ± 23.1 months, and 80% of patients achieved complete remission, while 20% achieved partial remission. Erythrocyte sedimentation rate, C-reactive protein, frequency of attacks, and patient global assessment decreased significantly after CAN (p < 0.001 for each). The mean serum creatinine level (mg/dl) decreased from 2.1 ± 0.8 to 1.4 ± 0.8 (p < 0.001), and median proteinuria (mg/day) decreased from 1475 to 675 (p < 0.001) in patients with AA-amyloidosis. Only one patient with chronic monoarthritis affecting the wrist discontinued CAN due to insufficient arthritis relief. Canakinumab demonstrates excellent efficacy and favorable safety as a treatment for cr-FMF. Our study is the first to indicate the efficacy of CAN in reducing serum creatinine levels.
A case of AA amyloidosis with biliary cystadenoma and cervical thymoma in a striped skunk (Mephitis mephitis).
A 6-year and 11-months-old male striped skunk, Mephitis mephitis, showed inappetence and died. Necropsy revealed multiple hepatic masses, an enlarged spleen, wedge-shaped lesions in the kidneys, and a cervical cyst with white nodules. Histopathologically, the hepatic masses were diagnosed as biliary cystadenomas accompanied by chronic inflammation, the cervical cyst was a thymoma, and the splenic and renal lesions were diagnosed as infarctions. Amorphous eosinophilic material was observed in the liver, spleen, and kidney. These proteinaceous deposits were positive for Congo red staining with yellowish to green birefringence under polarized light. These deposits were immunohistochemically positive for amyloid A (AA). This report describes the pathological features of AA amyloidosis, biliary cystadenoma and cervical thymoma in a striped skunk.
AA amyloidosis with clinically overt cardiac involvement confirmed by amyloid A deposition in aortic valve fibroelastoma.
AA amyloidosis in inflammatory joint diseases in the era of biological therapies: prevalence, manifestations, management and evolution.
AA amyloidosis (AAA) is a complication of chronic inflammation whose burden is expected to decrease in the era of biological therapies. We assessed the prevalence, clinical and laboratory manifestations, management and evolution of AAA in patients with inflammatory joint diseases (IJDs). We retrospectively assessed adults followed from 2008 to 2025 in 2 French tertiary university hospitals. AAA had to be histologically confirmed and related to one of the following IJDs: rheumatoid arthritis, spondylarthritis, juvenile idiopathic arthritis, undifferentiated arthritis or gout. The prevalence of rheumatoid arthritis- and spondylarthritis-related AAA was low, estimated at 0.6‰ and 0.5‰, respectively. We identified 15 patients with IJD-related AAA: 5 rheumatoid arthritis, 4 spondylarthritis, 2 juvenile idiopathic arthritis, 3 undifferentiated arthritis and 1 gout. Ten (66.7%) patients were from developing countries. All patients experienced delays in diagnosis and treatment. At AAA diagnosis, most patients (80%) were not receiving any treatment for IJD. AAA clinical manifestations were mainly renal and digestive; the median (interquartile range) C-reactive protein level was 41.5 (16.8-59.5) mg/L, serum amyloid A level 31 (13-44) mg/L and proteinuria/creatinuria ratio 3.5 (1.3-5.2) g/mmol. Biological disease-modifying anti-rheumatic drugs were started in 14 patients (1 patient lost to follow-up) and resulted in clinically inactive disease in 57.2%; normal C-reactive protein and serum amyloid A and proteinuria negativity in 71.4%. In the last 2 decades, AAA occurred in only patients with IJDs who experienced long diagnostic and therapeutic delays, mainly related to country of origin and difficulties in access to care.
Case Report: Anti-TNF-α therapy-associated destructive thyroiditis and unmasking of latent amyloid A amyloidosis in rheumatoid arthritis.
Tumor necrosis factor (TNF)-α inhibitors are widely used for rheumatoid arthritis (RA), but paradoxical immune reactions, including autoimmune thyroid disease, have been reported. We describe a 71-year-old man with a 16-year history of RA who developed destructive thyroiditis after initiation of certolizumab pegol. Despite symptom resolution, he subsequently developed acute renal failure and diarrhea. Biochemical and histological analyses revealed elevated serum amyloid A (AA) and amyloid deposition in the kidney and duodenum, confirming AA amyloidosis. We considered that the latent amyloidosis became clinically apparent following immune modulation by the anti-TNF-α biologic. Treatment with the IL-6 receptor antibody tocilizumab rapidly normalized inflammatory markers and improved both renal function and gastrointestinal symptoms. This case highlights that TNF-α inhibition may paradoxically unmask underlying amyloidosis and induce autoimmune thyroiditis. Clinicians should monitor thyroid and systemic amyloid markers when introducing biologic therapy for long-standing RA.
Publicações recentes
Oral AA amyloidosis with granulomatous cheilitis: a case report and literature review.
🥉 Relato de casoDual Diagnosis of Thyroid Amyloidosis and Lipomatosis: An Uncommon Concurrence.
💬 OpiniãoChronic Brucella infection associated with amyloid light chain cardiac amyloidosis: a case report.
Protective Effect of Paeoniae Radix Alba Carbonisata on Hepatic Amyloidosis by Regulating Calcium Homeostasis.
A missense mutation in the SAA1 protein causing hereditary amyloid A amyloidosis.
📚 EuropePMC610 artigos no totalmostrando 196
AA amyloidosis in inflammatory joint diseases in the era of biological therapies: prevalence, manifestations, management and evolution.
Joint bone spineCase Report: Anti-TNF-α therapy-associated destructive thyroiditis and unmasking of latent amyloid A amyloidosis in rheumatoid arthritis.
Frontiers in immunologyCanakinumab treatment in patients with colchicine-resistant familial mediterranean fever: a multicenter observational study.
Turkish journal of medical sciencesChildhood-onset hypocomplementaemic urticarial vasculitis in France: phenotypic and genotypic diversity in 10 children.
Pediatric rheumatology online journalAssociation Between Common Variable Immunodeficiency and Pulmonary Amyloidosis: Review.
Journal of clinical medicineGraft and Recipient Survival Analysis of Renal Transplantation in Rheumatic Diseases: A Retrospective Case-Control Study.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ TransplantationStroke characteristics in giant cell arteritis and Takayasu arteritis: A multicenter retrospective cohort study of 108 patients.
Seminars in arthritis and rheumatismTocilizumab prevented the progression of AA amyloidosis derived from adult-onset Still's disease.
Clinical nephrologyThrombosis Despite Sub-Nephrotic Proteinuria.
CureusRenal Biopsy as a Diagnostic Salvage Modality in Gouty Nephropathy Coexisting With Amyloid A Amyloidosis.
International journal of surgical pathologyAn intriguing case report of coincidental occurrence of Amyloid A amyloidosis with renal cell carcinoma in the ipsilateral kidney and adrenal gland.
Indian journal of pathology & microbiologyIn situ, antibody-independent, and multiplexed characterization of amyloid plaques by MALDI MS/MS imaging using iprm-PASEF.
Analytical and bioanalytical chemistryThe Interplay Between Rheumatoid Arthritis and Chronic Kidney Disease: From Mechanisms to Treatment.
Journal of clinical medicineAssessment of the biochemical basis underlying the resistance against systemic amyloidosis.
Scientific reportsPrognostication: A Young Patient With AA Amyloidosis.
CureusDestabilization of Helix III Initiates Early Serum Amyloid A Misfolding by Exposing Its Amyloidogenic Core.
The journal of physical chemistry lettersEndoscopic Diagnosis and Clinical Course of Isolated Upper Gastrointestinal Amyloidosis: A Retrospective Observational Study.
The Korean journal of helicobacter and upper gastrointestinal researchThe Inflammatory Role of Serum Amyloid A in the Pathogenesis and Progression of Diabetic Nephropathy.
Journal of clinical medicineAmyloid A Amyloidosis Secondary to Thymoma.
Diagnostics (Basel, Switzerland)Amyloid A amyloidosis associated with Streptococcus suis infection in a young commercial pig with wild-type serum amyloid A.
Veterinary research communicationsEfficacy and safety of anti-interleukin-6 treatment in familial Mediterranean fever: a systematic literature review.
ReumatologiaEarly-onset gastrointestinal amyloid A amyloidosis without renal involvement in a patient with RA-pSpA overlap: A case report.
MedicineEpigallocatechin-3-Gallate: A potential amyloid Fibril Disaggregator of Serum amyloid A1.
Biochemistry and biophysics reportsAA amyloidosis with clinically overt cardiac involvement confirmed by amyloid A deposition in aortic valve fibroelastoma.
European heart journalCase Report: A rare case of concurrence of IgG4-related tubulointerstitial nephritis and renal Amyloid A amyloidosis.
Frontiers in immunologyAA amyloidosis as an adverse event of immune checkpoint inhibitor therapy: evidence from the FDA adverse event reporting system and a systematic review.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of AmyloidosisRenal AA amyloidosis following COVID-19 infection.
Nephrologie & therapeutiqueA case of AA amyloidosis with biliary cystadenoma and cervical thymoma in a striped skunk (Mephitis mephitis).
The Journal of veterinary medical science[An unusual cause for kidney transplantation].
Innere Medizin (Heidelberg, Germany)Clinical profile and outcome of AA amyloidosis associated kidney disease in India.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of AmyloidosisCase Report: Expanding the spectrum of renal involvement in adult-onset still's disease: a case of focal proliferative glomerulonephritis and ischemic nephropathy.
Frontiers in medicineFrom ulcerative colitis to amyloid storm: a case-based review.
Rheumatology internationalEffect of MEFV mutations and HLA-B27 on clinical findings of familial Mediterranean fever and spondyloarthritis.
MedicineAmyloid and Light Chain Deposition Disorders.
Clinics in chest medicineThe decline of AA amyloidosis in familial Mediterranean fever is significant, but the story is not over.
Clinical and experimental rheumatologyRenal AA Amyloidosis Associated With Systemic Lupus Erythematosus Treated With Anakinra.
The Journal of rheumatologyComparative Histopathological Characteristics of Duodenal Involvement in Different Types of Amyloidosis.
BiomedicinesCryo-EM Observation of AA Amyloid Fibrils in Mouse Model of Systemic AApoAII Amyloidosis.
Journal of molecular biologyAcquired Renal Amyloidosis in a Patient With X-Linked Hyper-IgM Immunodeficiency With Novel Hemizygotic Pathogenic Variant in CD40LG Gene.
Case reports in nephrologyCarpal tunnel syndrome with both AA amyloidosis and elderly-onset Still disease: A case report.
MedicineSecondary amyloidosis as a cause of nephrotic syndrome in Takayasu arteritis.
BMJ case reportsIdiopathic AA amyloidosis presenting with initial abdominal pain: a case report and literature review.
Frontiers in medicineAA-Amyloidosis in the Eurasian stone-curlew (Burhinus oedicnemus).
PloS oneSerum Amyloid A3 Expression Is Enhanced by Gram-Negative Bacterial Stimuli in Bovine Endometrial Epithelial Cells.
Pathogens (Basel, Switzerland)Systemic AA Amyloidosis Secondary to Chronic Bronchiectasis and Primary Immunodeficiency: A Case Report.
CureusAcute Renal Failure Due to Amyloidosis Associated With Intravenous Heroin Use.
CureusPre-existing oncohematological disease in kidney transplant recipients: impact on graft survival, acute rejection, and long-term clinical outcomes.
Frontiers in immunologyUnmasking Tumor Necrosis Factor Receptor-Associated Periodic Syndrome (TRAPS): Diagnostic pitfalls of de novo mutations.
The journal of allergy and clinical immunology. In practiceA Rare Case of Cerebral Amyloidoma Mimicking Thalamic Glioma in a Rheumatoid Arthritis Patient.
Pathophysiology : the official journal of the International Society for PathophysiologyR202Q homozygosity in the MEFV gene may not be classified as classical FMF.
European journal of internal medicineA Rare Cause of Childhood Nephrotic Syndrome: AA Amyloidosis in Epidermolysis Bullosa.
CureusPolymorphisms in SAA alter intrarenal amyloid distribution of AA amyloidosis in cats.
Scientific reportsTransient elastography measurements of the liver and transplanted kidney in patients with AA amyloidosis: a cross-sectional comparative study.
Rheumatology internationalAA amyloidosis with multiorgan involvement secondary to familial Mediterranean fever (FMF): dreadful consequences of delayed diagnosis and management.
BMJ case reportsEfficacy and safety of treatments in familial Mediterranean fever and its complications: a systematic review informing the EULAR/PReS recommendations for familial Mediterranean fever.
Annals of the rheumatic diseases[Frequency and clinical and laboratory features of ankylosing spondylitis with secondary AA-amyloidosis].
Terapevticheskii arkhivA comprehensive evaluation of cardiac amyloidosis epidemiology and diagnostics in French Guiana.
PloS oneAA amyloidosis in inflammatory joint diseases: A systematic review.
Seminars in arthritis and rheumatismSurveillance of amyloid A deposits in commercial beef liver and assessment of food hygiene risks.
The Journal of veterinary medical scienceEpidemiology and clinical presentation of kidney amyloidosis have changed over the past three decades: a nationwide population-based study.
BMC nephrologyAmyloidosis in Human Inborn Errors of Immunity Predicts Poor Prognosis.
Journal of clinical immunologyEULAR/PReS endorsed recommendations for the management of familial Mediterranean fever (FMF): 2024 update.
Annals of the rheumatic diseasesMannheimia granulomatis-Infected Pyogranulomatous Oral Lesions with Concurrent Amyloidosis in Roe Deer (Capreolus capreolus) in France.
Journal of wildlife diseasesUse of Biologic Therapy in AA Amyloidosis Patients Undergoing Dialysis-A Systematic Literature Review.
Hemodialysis international. International Symposium on Home HemodialysisDigital clubbing, an unfamiliar feature of cryopyrin-associated periodic syndrome: A cohort study.
Journal of the American Academy of DermatologySystemic amyloid A amyloidosis secondary to chronic enteritis in a captive little owl (Athenenoctua).
Journal of comparative pathologyConcurrent extramedullary hematopoiesis and AA amyloidosis in the kidney.
NefrologiaCanakinumab Treatment in Familial Mediterranean Fever Patients: With/Without Colchicine.
International journal of rheumatic diseasesThe evolving spectrum of kidney amyloidosis: advances in diagnosis, typing and treatment.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal AssociationSystemic AA amyloidosis with amyloid deposition in the peritoneum at the time of initiating peritoneal dialysis.
CEN case reportsSerum Amyloid A Binding to Glycosaminoglycans is Synergistic with Amyloid Formation: Therapeutic Targeting in the Inflammation-linked Amyloidosis.
Journal of molecular biologyWaldenström's Macroglobulinemia/Lymphoplasmacytic Lymphoma Developing Renal AA Amyloidosis: A Case Report and Literature Review.
Internal medicine (Tokyo, Japan)Renal outcomes and survival in amyloidosis associated with familial Mediterranean fever: A longitudinal study.
Seminars in arthritis and rheumatismNew trends in AA amyloidosis with renal involvement: a single-center experience.
Jornal brasileiro de nefrologiaHepatic Amyloidosis Manifesting as Budd-Chiari Syndrome: An Unusual Presentation.
CureusCharacteristics and outcomes of adult patients with familial Mediterranean fever: Comparison of patients with one versus two pathogenic exon 10 MEFV mutations.
Joint bone spineThe question of strains in AA amyloidosis.
Scientific reportsIdentification and characterization of spontaneous AA amyloidosis in CD-1 mice used in toxicity studies: implications of SAA1 and SAA2 copy number variations.
Journal of toxicologic pathologyLiver Disease Complicating Familial Mediterranean Fever: A Study on 66 Patients Out of 533 Adult From the JIR Cohort.
Liver international : official journal of the International Association for the Study of the LiverPerformance of serum IL-18 levels for the follow-up of patients with familial Mediterranean fever.
The journal of allergy and clinical immunology. In practiceAmyloid light chain and amyloid A protein, two types of gastrointestinal amyloidosis.
Revista espanola de enfermedades digestivasInflammatory biomarker analysis confirms reduced disease severity in heterozygous patients with familial Mediterranean fever.
RMD openSecondary Amyloidosis Treated with Tocilizumab as a Complication of Temporal Arteritis.
European journal of case reports in internal medicineCo-occurrence of Primary Tracheal Diffuse Large B-Cell Lymphoma and Pulmonary AA Amyloidosis: A Unique Case Report.
Internal medicine (Tokyo, Japan)Renal colocalisation of Rosai-Dorfman-Destombes disease and secondary AA amyloidosis successfully treated with lenalidomide and dexamethasone.
The Lancet. HaematologyReal-Time 3D Imaging and Inhibition Analysis of Human Serum Amyloid A Aggregations Using Quantum Dots.
International journal of molecular sciencesAA amyloidosis in vertebrates: epidemiology, pathology and molecular aspects.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis[Clinical aspects of systemic amyloidosis in 2024].
Annales de pathologieHistopathological and Immunohistochemical Characteristics of Different Types of Cardiac Amyloidosis.
International journal of molecular sciencesUrinary Chemokines CXCL9 and CXCL10 Are Non-Invasive Biomarkers of Kidney Transplant Rejection.
Annals of transplantationCases report: Unexpected arterial thromboembolic events without cardiac involvement in two AA amyloidosis patients.
International journal of rheumatic diseasesSystemic amyloidosis: an aggressive evolution in a patient with relapsing polychondritis and monoclonal gammopathy of undetermined significance (MGUS) undergoing peritoneal dialysis.
Autopsy & case reportsSystemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease.
Annals of the rheumatic diseasesDiagnostic delays in familial Mediterranean fever: a Juvenile Inflammatory Rheumatism (JIR) cohort study.
Rheumatology internationalUncovering the knowledge about systemic amyloidosis relevant to the rheumatologists.
Advances in rheumatology (London, England)HGA Triggers SAA Aggregation and Accelerates Fibril Formation in the C20/A4 Alkaptonuria Cell Model.
CellsPregnancy occurring in AA amyloidosis: a series of 27 patients including 3 new French cases.
Journal of nephrologyCase 28-2024: A 75-Year-Old Woman with Edema, Arthritis, and Proteinuria.
The New England journal of medicineHeterozygous MEFV Mutation Leading to Renal Failure: A Case Study.
Global pediatric healthAA amyloidosis: An uncommon case presenting with a polyneuropathy.
Journal of the neurological sciencesImplication of the LRR Domain in the Regulation and Activation of the NLRP3 Inflammasome.
CellsSuccessful treatment of aggressive AA amyloidosis with tocilizumab in a patient with polymyalgia rheumatica.
Modern rheumatology case reportsKey charged residues influence the amyloidogenic propensity of the helix-1 region of serum amyloid A.
Biochimica et biophysica acta. General subjectsNon-Immunoglobulin Amyloidosis-Mediated Kidney Disease: Emerging Understanding of Underdiagnosed Entities.
Advances in kidney disease and health"Cruising together"-ASC specks and SAA, a perfect match in chronic inflammation.
EMBO molecular medicineThe ASC inflammasome adapter governs SAA-derived protein aggregation in inflammatory amyloidosis.
EMBO molecular medicineAuthentic hSAA related with AA amyloidosis: New method of purification, folding and amyloid polymorphism.
Biophysical chemistryDetecting Amyloid Goiter With 99mTc-PYP SPECT/CT in the Setting of Ankylosing Spondylitis: An Uncommon Involvement of AA Amyloidosis.
Clinical nuclear medicineStudies on the potential risk of amyloidosis from exposure to cultured fibril from silk fibroin.
Biomedical physics & engineering expressCould tocilizumab be used in familial Mediterranean fever? A systematic review.
Rheumatology (Oxford, England)Kidney Amyloidosis: Updates on Pathogenesis and Therapeutic Frontiers.
American journal of nephrologyRenal alterations in cats (Felis catus) housed in shelters and affected by systemic AA-amyloidosis: Clinicopathological data, histopathology, and ultrastructural features.
Veterinary pathologyThromboembolic and bleeding risk in cardiac amyloidosis.
Journal of thrombosis and haemostasis : JTHLate initiation of anakinra can induce complete renal response in renal AA amyloidosis secondary to Familial Mediterranean Fever.
Journal of nephrologyDeactivation of the Unfolded Protein Response Aggravated Renal AA Amyloidosis in HSF1 Deficiency Mice.
Molecular and cellular biologyAdvancing Care for AA Amyloidosis with Biomarker-Based Staging.
Journal of the American Society of Nephrology : JASNCoronavirus Disease 2019 Outcomes in Amyloid A Protein Amyloidosis Secondary to Rheumatic Conditions and Signs of Post- Coronavirus Disease 2019 Proteinuria Progression.
European journal of rheumatologyCardiac Amyloidosis: A Contemporary Review of Medical and Surgical Therapy.
Current cardiology reviewsbDMARD can prevent the progression of AA amyloidosis to end-stage renal disease.
Annals of the rheumatic diseasesRenal manifestations in adult-onset Still's disease: a systematic review.
Rheumatology internationalHistoric characteristics and mortality of patients in the Swiss Amyloidosis Registry.
Swiss medical weeklyPreclinical evaluation of Tc-99m p5+14 peptide for SPECT detection of cardiac amyloidosis.
PloS oneAA Amyloidosis: A Contemporary View.
Current rheumatology reportsSystemic Amyloid A Protein Amyloidosis With Gastrointestinal Involvement.
ACG case reports journalA rare clinical case of systemic AA amyloidosis with cardiac involvement complicating ankylosing spondylitis: a case report.
The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of CardiologyFunctional diversity of NLRP3 gain-of-function mutants associated with CAPS autoinflammation.
The Journal of experimental medicineA case of AA amyloidosis complicated by proliferating pilomatricoma and a review of the literature.
The Journal of dermatologyDiagnosis traps for patients with acquired NLRP3 mutation.
European journal of internal medicineDevelopment and Validation of Staging Systems for AA Amyloidosis.
Journal of the American Society of Nephrology : JASNWaldenstrom macroglobulinaemia with AA amyloidosis reveals a B-cell-restricted NLRP2 variant.
British journal of haematologyPredicting genetic risk factors for AA amyloidosis in Algerian patients with familial Mediterranean fever.
Molecular genetics and genomics : MGGElevated expression of interleukin-6 (IL-6) and serum amyloid A (SAA) in the skin and the serum of recessive dystrophic epidermolysis bullosa: Skin as a possible source of IL-6 through Toll-like receptor ligands and SAA.
Experimental dermatologyIsolated AL Amyloidosis of the Colon: A Rare Presentation.
ACG case reports journalAA amyloidosis With Ig-Dominant Staining and Diagnostically Unusual Features.
Kidney international reportsTocilizumab (anti-IL-6) treatment for AA renal amyloidosis in a patient with advanced chronic kidney disease, a case report.
Journal of nephrologyAcute Tubulointerstitial Nephritis and Secondary Renal Amyloidosis: A Rare Complication of Atezolizumab.
CureusA comparative urinary proteomic and metabolomic analysis between renal aa amyloidosis and membranous nephropathy with clinicopathologic correlations.
Journal of proteomicsSingle Nucleotide Polymorphisms Associated with AA-Amyloidosis in Siamese and Oriental Shorthair Cats.
GenesSymptomatic SARS-CoV2 infection associated with high mortality in AA amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis[Renal AA amyloidosis revealing extramedullary plasmocytoma].
Nephrologie & therapeutiqueA rare cause of AA amyloidosis: Glomus tumor and treatment with anakinra-Case report and literature review.
International journal of rheumatic diseasesRenal amyloid-A amyloidosis in cats: Characterization of proteinuria and biomarker discovery, and associations with kidney histology.
Journal of veterinary internal medicineSystemic AA Amyloidosis Secondary to Metastatic Renal Cell Carcinoma in a Hemodialysis Patient with Intractable Diarrhea.
Case reports in gastroenterologyHistological evaluation of the distribution of systemic AA-amyloidosis in nine domestic shorthair cats.
PloS oneFrench protocol for the diagnosis and management of familial Mediterranean fever.
La Revue de medecine interneKidney Biopsy Corner: Amyloidosis.
Glomerular diseasesPredictive Clinical and Biological Criteria for Gene Panel Positivity in Suspected Inherited Autoinflammatory Diseases: Insights from a Case-Control Study.
GenesPathomorphological Features of the Novel Coronavirus Disease in Patients with Systemic Amyloidosis.
BiomedicinesUnicentric Castleman's disease presenting as amyloid A cardiac amyloidosis: a case report.
Annals of hematologyBehçet's syndrome: one year in review 2023.
Clinical and experimental rheumatologyPathological Characterization of Spontaneous AA Amyloidosis in Microminipigs.
Toxicologic pathologyAA amyloidosis in a father and daughter as complication of PSTPIP1-associated myeloid-related proteinemia inflammatory (PAMI) syndrome.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of AmyloidosisA rare case of hydatid cyst-associated AA amyloidosis and literature review of hydatid cyst-associated nephropathy.
Infectious diseases (London, England)Development and characterization of a prototypic pan-amyloid clearing agent - a novel murine peptide-immunoglobulin fusion.
Frontiers in immunologyHyperspectral Raman Imaging for Automated Recognition of Human Renal Amyloid.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry SocietyNephrotic Syndrome in a Retroviral Disease Due to AA Amyloidosis: A Rare Presentation.
CureusInvestigation of serum amyloid a within animal species focusing on the 1-25 amino acid region.
The veterinary quarterlySuccessful Pregnancy Outcome in a Patient with Juvenile Idiopathic Arthritis in Adulthood, Amyloid A Amyloidosis, and Chronic Kidney Disease Using Tocilizumab with Strict Blood Pressure Control.
Internal medicine (Tokyo, Japan)Clinical presentation and genetic variants in patients with autoinflammatory diseases: results from the German GARROD registry.
Rheumatology internationalKidney Transplantation in Patients With AA Amyloidosis: Outcomes in a French Multicenter Cohort.
American journal of kidney diseases : the official journal of the National Kidney FoundationCharacteristics and course of patients with AA amyloidosis: single centre experience with 174 patients from Turkey.
Rheumatology (Oxford, England)Therapeutic effects of biological treatments on AA amyloidosis associated with inflammatory bowel disease: a case report and literature review.
European journal of gastroenterology & hepatologyThe spectrum of pulmonary amyloidosis.
Respiratory medicine[Autoinflammatory syndromes].
Zeitschrift fur RheumatologieIntestinal Reactive Amyloid A (AA) Amyloidosis in a Patient With Multiple Myeloma: A Case Report and Literature Review.
CureusStress-mediated aggregation of disease-associated proteins in amyloid bodies.
Scientific reportsNakajo-Nishimura Syndrome: The First African Case.
Mediterranean journal of rheumatologyVector autoregression: Useful in rare diseases?-Predicting organ response patterns in a rare case of secondary AA amyloidosis.
PloS oneChemical design of radioiodinated probes with a metabolizable linkage for target-selective imaging of systemic amyloidosis.
Bioorganic & medicinal chemistryKidney dysfunction due to AA amyloidosis in a morbidly obese female.
Clinical nephrology. Case studiesSecondary amyloidosis with concomitant gastric GIST and gastric adenocarcinoma - A case report.
Indian journal of pathology & microbiologyCOVID-19 Infection and Vaccination and Its Relation to Amyloidosis: What Do We Know Currently?
VaccinesPathogenic variants in the NLRP3 LRR domain at position 861 are responsible for a boost-dependent atypical CAPS phenotype.
The Journal of allergy and clinical immunologyKidney Involvement in Autoinflammatory Diseases.
Kidney diseases (Basel, Switzerland)AA-type amyloidosis associated with lymphoma: a study of 19 cases including 5 new French cases and a systematic literature review.
Leukemia & lymphomaGastrointestinal AA Amyloidosis following Recurrent SARS-CoV-2 Infection: A Case Report.
Yonsei medical journalTNFRSF1A-pR92Q variant identifies a subset of patients more similar to systemic undifferentiated recurrent fever than TNF receptor-associated periodic syndrome.
Clinical and experimental rheumatologyHuman lysozyme inhibits the fibrillation of serum amyloid a protein from systemic AA amyloidosis.
Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of AmyloidosisSystemic Amyloid A Amyloidosis Secondary to Xanthogranulomatous Pyelonephritis.
Internal medicine (Tokyo, Japan)Gut microbiota alterations are associated with phenotype and genotype in familial Mediterranean fever.
Rheumatology (Oxford, England)Comparing COVID-19 disease severity in patients with rheumatic and inflammatory diseases between the first and the subsequent waves.
Joint bone spineGout With Associated Cutaneous AA Amyloidosis: A Case Report and Review of the Literature.
British journal of biomedical scienceAA amyloidosis of unknown aetiology: response to treatment with interleukin-1 inhibitors.
Clinical kidney journalRenal involvement in monogenic autoinflammatory diseases: A narrative review.
Nephrology (Carlton, Vic.)Gastroparesis: an under-recognised manifestation of systemic amyloidosis.
BMJ case reportsInfluences of amino-terminal modifications on amyloid fibril formation of human serum amyloid A.
Archives of biochemistry and biophysicsRenal Amyloid-Associated (AA) Amyloidosis in a Sickle Cell Patient: A Case Report and Literature Review.
CureusPost COVID-19 AA amyloidosis of the kidneys with rapidly progressive renal failure.
PrionCase report: Rapid development of amyloid A amyloidosis in temporal arteritis with SAA1.3 allele; An unusual case of intestinal amyloidosis secondary to temporal arteritis.
Frontiers in immunologyAA-amyloidosis in cats (Felis catus) housed in shelters.
PloS one[A case of systemic amyloidosis presenting with gastric emphysema].
Nihon Shokakibyo Gakkai zasshi = The Japanese journal of gastro-enterologyRenal involvement, presence of amyloidosis, and genotype-phenotype relationship in pediatric patients with Familial Mediterranean fever: a single center study.
European journal of pediatricsFrench practical guidelines for the diagnosis and management of AA amyloidosis.
La Revue de medecine interneA novel TNFRSF1A mutation associated with TNF-receptor-associated periodic syndrome and its metabolic signature.
Rheumatology (Oxford, England)Renal involvement in familial Mediterranean fever in an Algerian population.
Clinical nephrologyA Comprehensive Multidisciplinary Diagnostic Algorithm for the Early and Efficient Detection of Amyloidosis.
Clinical lymphoma, myeloma & leukemiaAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Canakinumab treatment in patients with colchicine-resistant familial mediterranean fever: a multicenter observational study.
- A case of AA amyloidosis with biliary cystadenoma and cervical thymoma in a striped skunk (Mephitis mephitis).
- AA amyloidosis with clinically overt cardiac involvement confirmed by amyloid A deposition in aortic valve fibroelastoma.
- AA amyloidosis in inflammatory joint diseases in the era of biological therapies: prevalence, manifestations, management and evolution.
- Case Report: Anti-TNF-α therapy-associated destructive thyroiditis and unmasking of latent amyloid A amyloidosis in rheumatoid arthritis.
- Oral AA amyloidosis with granulomatous cheilitis: a case report and literature review.
- Dual Diagnosis of Thyroid Amyloidosis and Lipomatosis: An Uncommon Concurrence.
- Chronic Brucella infection associated with amyloid light chain cardiac amyloidosis: a case report.
- Protective Effect of Paeoniae Radix Alba Carbonisata on Hepatic Amyloidosis by Regulating Calcium Homeostasis.
- A missense mutation in the SAA1 protein causing hereditary amyloid A amyloidosis.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:85445(Orphanet)
- MONDO:0019439(MONDO)
- GARD:10560(GARD (NIH))
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q2844591(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
