A Ceratoconjuntivite Vernal (CV) é uma alergia grave e crônica que afeta a superfície dos olhos. Ela atinge principalmente meninos que vivem em climas quentes e secos. As crises de CV são comuns na primavera (época que dá nome à doença) e no verão, mas podem reaparecer no inverno. Os sinais e sintomas geralmente começam antes dos 10 anos e podem incluir: bolinhas duras, que parecem 'paralelepípedos' (chamadas papilas) na pálpebra superior; sensibilidade à luz; vermelhidão; secreção de muco pegajosa; e piscar involuntário ou espasmos da pálpebra (blefaroespasmo). A condição geralmente desaparece com o início da puberdade. É causada por uma reação alérgica a alérgenos presentes no ar. O tratamento tem como objetivo prevenir as 'crises' e aliviar os sintomas da doença.
Introdução
O que você precisa saber de cara
A Ceratoconjuntivite Vernal (CV) é uma alergia grave e crônica que afeta a superfície dos olhos. Ela atinge principalmente meninos que vivem em climas quentes e secos. As crises de CV são comuns na primavera (época que dá nome à doença) e no verão, mas podem reaparecer no inverno. Os sinais e sintomas geralmente começam antes dos 10 anos e podem incluir: bolinhas duras, que parecem 'paralelepípedos' (chamadas papilas) na pálpebra superior; sensibilidade à luz; vermelhidão; secreção de muco pegajosa; e piscar involuntário ou espasmos da pálpebra (blefaroespasmo). A condição geralmente desaparece com o início da puberdade. É causada por uma reação alérgica a alérgenos presentes no ar. O tratamento tem como objetivo prevenir as 'crises' e aliviar os sintomas da doença.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 11 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 23 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Ceratoconjuntivite primaveril
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
25 ensaios clínicos encontrados, 5 ativos.
Publicações mais relevantes
Enigmatic Role of IL-31 in the Itch and Inflammation of Vernal Keratoconjunctivitis.
Vernal keratoconjunctivitis (VKC) is a recurrent allergic inflammation of the conjunctiva characterized by itchiness. The cytokine IL-31 is involved in itch and inflammation in other conditions, so we investigated whether it plays similar role in VKC. We estimated messenger RNA (mRNA) IL-31 expression in giant papillae (GP) with real-time polymerase chain reaction (RT-PCR). We used immunohistochemistry to examine IL-31 receptor (IL-31R) expression in neurons and epithelial cells in GP. We then performed fluorescence-activated cell sorting and immunofluorescence to examine IL-31R expression in cultured human conjunctival epithelial cells (HConEpiCs) either treated or not treated with various cytokines. Next, we examined the expression of phosphorylated signal transducer and activator of transcription 3 (P-STAT3) and suppressor of cytokine signaling 3 (SOCS3) in the epithelium of GP and control specimens using immunohistochemistry. Last, we used DNA microarray analysis and RT-PCR to investigate whether recombinant IL-31 induced expression of various genes in HConEpiCs. IL-31 expression was elevated in GP compared with control specimens. Although many neuron fibers innervated GP, none was found to express IL-31R. IL-31R was expressed in the epithelium of GP and in HConEpiCs, and its expression in HConEpiCs was not altered by any of the investigated cytokines. Recombinant IL-31 increased SOCS3 mRNA expression. Strong P-STAT3 expression was observed in the epithelium of GP, but SOCS3 expression was not observed. Increased IL-31 in GP of VKC patients may not directly influence itch sensation via neuron fibers and inflammation via the expression of P-STAT3 and SOCS3.
Effectiveness of Corticosteroid-Sparing Topical Treatments for Vernal Keratoconjunctivitis in Children: A Report by the American Academy of Ophthalmology.
To review the published literature assessing the efficacy of corticosteroid-sparing topical treatments for vernal keratoconjunctivitis (VKC) in children 18 years of age and younger. A literature search of the PubMed database was last conducted in August 2025 and limited to articles published in English without date restrictions. The search yielded 56 articles, which were reviewed by the primary author in abstract form; 24 were selected for full-text review. Fifteen articles met the inclusion criteria and were assigned a level of evidence rating by the panel methodologist. Six studies were rated level I, and 9 studies were rated level III. Level I evidence evaluated the efficacy of cyclosporine (4/6), tacrolimus (4/6), interferon alpha-2b (1/6), and sodium cromoglycate (1/6) ophthalmic preparations. Most level III evidence studies (5/9) reported outcomes using tacrolimus drops or ointment. Regardless of the medication, concentration, dosing frequency, or treatment duration, level I and level III evidence included in the assessment demonstrated that signs and symptoms of VKC in children can be improved with intervention. Apart from application site discomfort, the studies reported no significant adverse events. Level I and III evidence demonstrate that treatment with corticosteroid-sparing topical interventions such as cyclosporine, tacrolimus, sodium cromoglycate, and interferon alpha-2b can improve clinical signs and symptoms of VKC in children. Most of the level I evidence supports the use of the calcineurin inhibitors-cyclosporine and tacrolimus. Proprietary or commercial disclosure may be found after the references.
Changing Strategies in Keratoplasty After Corneal Hydrops: From Penetrating to Lamellar Approaches - A Narrative Review.
The hallmark of acute corneal hydrops (CH) is Descemet membrane (DM) rupture that leads to the influx of fluid into the cornea causing corneal edema. Multiple risk factors have been related to an increased incidence of CH in keratoconus (KC) patients, such as Down's syndrome, atopy, vernal keratoconjunctivitis, eye rubbing, and an earlier age of KC onset. Penetrating keratoplasty (PKP), deep anterior lamellar keratoplasty (DALK), compression sutures, cyanoacrylate tissue adhesive with bandage contact lens (BCL), intracameral gas injection, and amniotic membrane transplant (AMT) are some of the conservative and surgical methods used to treat CH. Compared to KC without a history of CH, the need for PKP in patients with healed hydrops is higher due to preexisting DM rupture. Thus, the majority of surgeons conduct PKP after CH. On the other hand, some corneal surgeons choose to perform DALK over PKP as it spares the host endothelium. In this narrative review, we compare DALK to PKP for corneal hydrops in KC, evaluating the challenges, advantages, and visual and refractive outcomes.
Corneal collagen cross-linking at diagnosis in pediatric keratoconus: A prospective study from the Indian Subcontinent.
To assess the one-year visual, refractive, and tomographic outcomes of corneal collagen cross-linking (CXL) performed at diagnosis in Indian children with keratoconus and to evaluate its safety in eyes with controlled vernal keratoconjunctivitis (VKC). Thirty-eight eyes of 30 children (9-18 years) diagnosed with keratoconus underwent standard epithelium-off CXL (Dresden protocol). "At diagnosis" was defined as treatment within four weeks of first topographic confirmation. Outcome measures included uncorrected visual acuity (UCVA), best spectacle-corrected visual acuity (BCVA), mean refractive spherical equivalent (MRSE), keratometric indices (flat K, steep K, apical K), pachymetry, and endothelial cell density. Statistical analysis included paired and adjusted comparisons with 95% confidence intervals (CIs). UCVA improved from 0.72 ± 0.46 to 0.45 ± 0.42 logMAR (P < 0.001) and BCVA from 0.37 ± 0.30 to 0.21 ± 0.28 logMAR (P < 0.001). MRSE improved by 1.72 D (P < 0.001). Steep K and apical K flattened by 2.02 D and 2.26 D respectively (P < 0.001). Endothelial cell counts were stable. Subgroup analysis showed no difference between VKC and non-VKC eyes. Three patients developed transient sterile infiltrates that resolved with medical therapy. Performing CXL at diagnosis is safe and effective in halting pediatric keratoconus progression while improving visual and refractive outcomes. Early treatment is particularly relevant for high-risk ethnic groups such as Indian children, where keratoconus is aggressive and rapidly progressive.
Factors associated with graft astigmatism after corneal transplantation for keratoconus.
Graft astigmatism remains a major impediment to early visual rehabilitation and the long-term success of keratoplasty. Previous studies have identified graft size, donor–recipient size discrepancy, timing of suture removal, and surgical indication as factors associated with postoperative graft astigmatism. However, these studies often included heterogeneous corneal pathologies and evaluated the effects of only one or a limited number of variables. The present study aimed to investigate factors associated with corneal graft astigmatism following corneal transplantation in a large cohort of patients with keratoconus. This retrospective, comparative interventional case series included 646 consecutive corneal transplants performed in 556 patients with keratoconus. Of these, 338 eyes underwent penetrating keratoplasty and 308 eyes underwent deep anterior lamellar keratoplasty. Postoperative keratometric astigmatism was assessed 3 to 12 months after complete suture removal. Generalized linear models were used to evaluate preoperative, intraoperative, and postoperative factors associated with postoperative keratometric astigmatism. The mean age at the time of keratoplasty was 29.3 ± 8.8 years. The mean postoperative keratometric astigmatism was 4.78 ± 2.24 D (range, 0.0–14.0 D). Increasing patient age (β = 0.05, P < 0.001) and a prior history of vernal keratoconjunctivitis (β = 0.49, P = 0.03) were significantly associated with greater postoperative keratometric astigmatism. Keratometric astigmatism was significantly higher in patients older than 30 years at the time of corneal transplantation. Deep anterior lamellar keratoplasty was associated with lower postoperative keratometric astigmatism during the second study period (β=−0.80, P = 0.008), when this technique was predominantly performed. Other variables, including keratoconus severity (P = 0.10), donor age (P = 0.10), graft rating (P = 0.37), donor trephine size (P = 0.27), donor–recipient disparity (P = 0.54), suturing technique (P = 0.88), selective suture removal (P = 0.07), duration of corticosteroid therapy (P = 0.70), time to complete suture removal (P = 0.30), and suture-related complications (P = 0.77), were not significantly associated with postoperative graft astigmatism. Age at the time of keratoplasty, a history of vernal keratoconjunctivitis, and possibly the keratoplasty technique were associated with postoperative graft astigmatism. Other intraoperative and postoperative variables were not significantly associated with keratometric astigmatism following corneal transplantation in patients with keratoconus. Why carry out this study? What was learned from the study? Graft astigmatism is the major impediment to early visual rehabilitation and the ultimate success of the keratoplasty. Previous studies have identified graft size, donor-recipient size discrepancy, time of suture removal, and the indications of keratoplasty as factors associated with graft astigmatism. These studies, however, included heterogeneous corneal pathologies and considered the effect of one or a few factors at the time. The present study evaluated the influence of various preoperative, intraoperative, and postoperative factors on post-keratoplasty keratometric astigmatism in a large number of keratoconus patients. Patient age, history of vernal keratoconjunctivitis, and, possibly, corneal transplantation technique were significantly correlated with post-keratoplasty keratometric astigmatism. Graft astigmatism had no association with keratoconus severity, donor age, graft rating, donor trephine size, suturing technique, duration of corticosteroid application, or time to complete suture removal.
Publicações recentes
Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases.
A red-eye presentation concerning for vernal keratoconjunctivitis: a case report.
Ultraviolet association with vernal keratoconjunctivitis with perilimbal pigmentation.
Treatment of vernal keratoconjunctivitis simulating total limbal stem cell deficiency: a case report.
Pediatric Vernal Keratoconjunctivitis (VKC): Current State and Future Directions-A Narrative Review of Clinical Features, Diagnostic Strategies, and Emerging Therapies.
📚 EuropePMC618 artigos no totalmostrando 198
Enigmatic Role of IL-31 in the Itch and Inflammation of Vernal Keratoconjunctivitis.
Juntendo medical journalEffectiveness of Corticosteroid-Sparing Topical Treatments for Vernal Keratoconjunctivitis in Children: A Report by the American Academy of Ophthalmology.
Ophthalmology[Regeneration potential and remodelling of juvenile cornea resulting from vernal keratoconjunctivitis].
Die OphthalmologieChanging Strategies in Keratoplasty After Corneal Hydrops: From Penetrating to Lamellar Approaches - A Narrative Review.
Clinical ophthalmology (Auckland, N.Z.)Corneal collagen cross-linking at diagnosis in pediatric keratoconus: A prospective study from the Indian Subcontinent.
Indian journal of ophthalmologyFactors associated with graft astigmatism after corneal transplantation for keratoconus.
BMC ophthalmologyOcular Allergy Within the Framework of the EAACI Nomenclature of Allergic Diseases and Hypersensitivity Reactions.
Allergy, asthma & immunology researchComparative Analysis of Inflammatory Mediators in Children, Adolescents, and Adults with Vernal Keratoconjunctivitis.
Seminars in ophthalmologyComprehensive assessment of tear film dynamics in pediatric vernal keratoconjunctivitis using a novel non-invasive device (MYAH).
Contact lens & anterior eye : the journal of the British Contact Lens AssociationExploring the Gut-Eye Axis: Microbial Dysbiosis in Vernal Keratoconjunctivitis.
CorneaPediatric Ocular Surface Inflammatory Diseases: Clinical Features and Practice Patterns.
CorneaArtificial Intelligence-Powered Interpretation of Corneal Epithelial Maps: A Comparative Pilot Study of ChatGPT, Google Gemini, and Microsoft Bing.
CureusSplendore-Hoeppli phenomenon in vernal keratoconjunctivitis: a rare photographic documentation in a paediatric case.
Eye (London, England)An update in vernal keratoconjunctivitis.
Indian journal of ophthalmologyPredictive Factors of Suboptimal Response to Topical 0.1% Cyclosporine A Cationic Emulsion in Pediatric Vernal Keratoconjunctivitis: A Real-World Retrospective Study.
Ophthalmology and therapyOutcomes of Collagen Crosslinking in Patients with Keratoconus and Co-Existent Limbal Stem Cell Deficiency.
Clinical ophthalmology (Auckland, N.Z.)Risk Factors Associated With Steroid-Induced Ocular Hypertension and Glaucoma in Patients With Vernal Keratoconjunctivitis in a North Indian Population: A Multicenter Study.
CureusLong-Term Outcomes of Deep Anterior Lamellar Keratoplasty in Pediatric Keratoconus: A 15-Year Retrospective Analysis.
CorneaChallenges in the management of microsporidial keratoconjunctivitis: recurrent infection and environmental contamination.
BMJ case reportsDecoding Allergic Conjunctivitis: Latest Perspectives on Etiological Drivers and Immunopathological Mechanisms.
Clinical reviews in allergy & immunologySurgical Management of Corneal Sequelae of Vernal Keratoconjunctivitis.
Seminars in ophthalmologyKeratoconus and quality of life: an updated comprehensive review.
BMC ophthalmology"Ocular Surface Disorders in Children": A Comprehensive Review of Pathogenesis, Diagnosis, and Management.
Seminars in ophthalmologyThe impact of tacrolimus therapy on the outcomes of vernal keratoconjunctivitis: a systematic review and meta-analysis.
Frontiers in medicineTopical Use of Tacrolimus in Corneal and Ocular Surface Pathologies: A Systematic Review.
Journal of clinical medicineAssociation of Serum Vitamin D, IgE, Eosinophils, and Time Spent Outdoor During Daylight with Disease Severity in Vernal Keratoconjunctivitis.
Ocular immunology and inflammationWhere eye meets body part 2: uniting allergy pathways in ocular and atopic disease - T cells take the lead.
Current opinion in allergy and clinical immunologyTomographic and biomechanical refractive findings in ocular pediatric allergy.
Japanese journal of ophthalmologyShield ulcer in keratoconus in the absence of atopic or vernal kerato-conjunctivitis.
GMS ophthalmology casesRecent Advances in Targeted Immunomodulatory Therapies for Chronic Ocular Surface Diseases.
Seminars in ophthalmologyMapping the Future: Anterior Segment OCT for Corneal Epithelial Thickness in Vernal Keratoconjunctivitis.
MaedicaTacrolimus Ophthalmic Suspension Can Be an Effective Treatment Option for Biologic-Induced Refractory Conjunctivitis.
CureusPrevalence of vernal keratoconjunctivitis in Canada: a cross-sectional survey study.
Canadian journal of ophthalmology. Journal canadien d'ophtalmologieThe psychological impact of vernal keratoconjunctivitis on families: An investigation on quality of life and psychological wellbeing.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyEfficacy of supratarsal traimcinolone injection in the treatment of recalcitrant vernal keratoconjunctivitis.
Pakistan journal of pharmaceutical sciencesVernal Keratoconjunctivitis: Impact on Children.
Eye & contact lensThe Role of Topical Cyclosporine A in Ocular Surface Inflammatory Disorders.
Seminars in ophthalmologyOcular Manifestations in Children with Vernal Keratoconjunctivitis.
Children (Basel, Switzerland)Steroid-Induced Ocular Hypertension in Children: A Review on Risk Factors.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and TherapeuticsThe evolving role of ciclosporin in the management of vernal keratoconjunctivitis.
Frontiers in ophthalmologyThe burden of antimicrobial resistance in biofilm forming Staphylococcus spp. from Vernal Keratoconjunctivitis patients eyes.
BiofilmEvaluating the Efficacy of Artificial Intelligence-Driven Chatbots in Addressing Queries on Vernal Conjunctivitis.
CureusVernal keratoconjunctivitis in human immunodeficiency positives: A case series.
Indian journal of ophthalmologyUnpacking VKC: How gender and age shape the clinical picture.
Indian journal of ophthalmologyImmunophenotyping in Vernal Keratoconjunctivitis: Schirmer Test for Therapy Response Prediction.
AllergyTopical tacrolimus versus dexamethasone in managing shield ulcer of vernal keratoconjunctivitis.
Medical hypothesis, discovery & innovation ophthalmology journalVernal keratoconjunctivitis: The burden of being allergic.
The journal of allergy and clinical immunology. GlobalProgress of Research and Comparative Analysis on the Combination of Mast Cell Stabilizers and Antihistamines in Allergic Conjunctivitis Treatment.
Ocular immunology and inflammationEfficacy and Safety of Topical Tacrolimus for Vernal Keratoconjunctivitis: A Systematic Review.
Beyoglu eye journalManaging Bilateral Vernal Keratoconjunctivitis, Keratoconus, and Steroid-Induced Glaucoma: A Threefold Struggle.
CureusCorneal Degeneration Secondary to Vernal Keratoconjunctivitis.
JAMA ophthalmologyCorticosteroid-sparing topical treatment with cyclosporin for juvenile keratoconjunctivitis.
Scientific reportsInsights from 1096 clinical cases: pioneering a universal grading system for vernal keratoconjunctivitis management.
The British journal of ophthalmologyOral Cyclosporine in Vernal Keratoconjunctivitis: Indications, Outcomes, and Effect on Corticosteroid Use.
CorneaThe Role of In Vivo Confocal Microscopy in Ocular Allergies.
Turkish journal of ophthalmologyEpidemiological insights into Childhood vernal keratoconjunctivitis in India: Unravelling clinical presentation and environmental influences - The EPIC VKC study - Fourth report of the ICMR EYE SEE study group.
The ocular surfaceEfficacy of Epinastine Eyelid Cream in Pediatric Vernal Keratoconjunctivitis: A Case Report.
CureusAn evaluation of corneal topographic changes in a large series of patients with vernal keratoconjunctivitis.
Journal francais d'ophtalmologieSerum Vitamin D Levels in Patients with Vernal Keratoconjunctivitis: A Systematic Review and Meta-Analysis.
Ocular immunology and inflammationEFFICACY OF TRANSEPITHELIAL ACCELERATED COLLAGEN CROSS LINKING IN STOPPING THE PROGRESSION OF KERATOCONUS.
Journal of Ayub Medical College, Abbottabad : JAMCOral mucous membrane tarsal patch grafting: broadening indications and long-term outcomes.
Orbit (Amsterdam, Netherlands)Efficacy of a Cationic Emulsion of Cyclosporine in Moderate Vernal Keratoconjunctivitis: Erratum.
CorneaPediatric keratoconus in a tertiary eye hospital in Eastern province, Saudi Arabia: Patient characteristics and management outcomes.
Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyRasch analysis of quality of life in children with vernal keratoconjunctivitis (QUICK) questionnaire.
Clinical & experimental optometryChallenging corneal diseases and microRNA expression: Focus on rare diseases and new therapeutic frontiers.
Survey of ophthalmologySeeing eye to eye: a modified Delphi method-based multidisciplinary expert consensus on the diagnosis and treatment of vernal keratoconjunctivitis.
European journal of pediatricsAssociation Between Pterygium and Ocular, Periocular, and Systemic Inflammatory Conditions: A Large-Scale National Study.
CorneaTear film parameters and meibography in eyes of children with vernal keratoconjunctivitis.
Indian journal of ophthalmologyAllergen Testing: A Review of the Indications, Procedures, and Limitations in Ocular Allergy.
Clinical reviews in allergy & immunologyLong-Term Observation of Prognostic Factors and Clinical Outcome of Vernal Keratoconjunctivitis in Childhood.
Clinical ophthalmology (Auckland, N.Z.)Screening Preadolescents for Keratoconus Risk Factors in a Low-Resource Setting.
Eye & contact lensUse of explainable AI on slit-lamp images of anterior surface of eyes to diagnose allergic conjunctival diseases.
Allergology international : official journal of the Japanese Society of AllergologyHealth-related Quality of Life in Children with Vernal Keratoconjunctivitis in Malaysia.
Korean journal of ophthalmology : KJOCombined Papillectomy and Autologous Conjunctival Membrane Graft as Management of Giant Papillae for Severe, Refractory Palpebral Vernal Keratoconjunctivitis-A Case Report.
Case reports in ophthalmological medicineUnraveling the complexity - Insights and interventions of refractory vernal keratoconjunctivitis.
The ocular surfaceCentral corneal thickness and topographic indices in Malaysian children with vernal keratoconjunctivitis.
The Medical journal of MalaysiaTopical Tacrolimus in Anterior Segment Disorders in Ophthalmology: A Review.
Romanian journal of ophthalmologyJACQLQ subjective symptom questionnaire score and clinical test results for patients with allergic conjunctival disease.
Scientific reportsEvaluation of Meibomian Gland Structure and Function in Patients with Vernal Keratoconjunctivitis Using Non Contact Meibography and Lipid Layer Interferometry.
Ocular immunology and inflammationVernal keratoconjunctivitis in adults: a narrative review of prevalence, pathogenesis, and management.
Frontiers in ophthalmologySystemic Treatment With Cyclosporine A in Children With Severe Vernal Keratoconjunctivitis.
CorneaA Case of Refractory Vernal Keratoconjunctivitis Showing Improvement after the Administration of Upadacitinib for the Treatment of Atopic Dermatitis.
Diagnostics (Basel, Switzerland)Reversal of Peripheral Anterior Synechiae After Trabeculectomy With Argon Laser Synechiolysis.
CureusSerum vitamin D levels in children with vernal keratoconjunctivitis - A study from a tertiary care pediatric hospital of North India.
Indian journal of ophthalmologyAnti-interleukin 5 for treating severe refractory vernal keratoconjunctivitis in children: Two cases.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyTreatment of Vernal Keratoconjunctivitis Using Upadacitinib.
JAMA ophthalmologyTranslation, adaptation, and psychometric properties of the Brazilian-Portuguese version of the Quality of Life in Children with Vernal Keratoconjunctivitis questionnaire.
Arquivos brasileiros de oftalmologiaEndoplasmic Reticulum Stress and Unfolded Protein Response in Vernal Keratoconjunctivitis.
Investigative ophthalmology & visual scienceVernal Keratoconjunctivitis: Immunopathological Insights and Therapeutic Applications of Immunomodulators.
Life (Basel, Switzerland)Applications of topical immunomodulators enhance clinical signs of vernal keratoconjunctivitis (VKC) and atopic keratoconjunctivitis (AKC): a meta-analysis.
International ophthalmologyEvaluation of Autophagy in Conjunctival Fibroblasts.
Methods in molecular biology (Clifton, N.J.)Limbal stem cell deficiency: Demography, aetiology, and clinical presentation in Eastern India.
Journal of family medicine and primary careReserve drug as first-line management: Topical interferon α-2b for vernal keratoconjunctivitis.
Indian journal of ophthalmologyPrevalence and risk factors of Vernal Keratoconjunctivitis among a Ghanaian clinical cohort: A case-control study.
Health science reportsA Patient-Centered Approach to Vernal Keratoconjunctivitis (VKC): A Podcast.
Ophthalmology and therapyTacrolimus Ointment in Periorbital Atopic Dermatitis.
CureusOcular surface squamous neoplasia masquerading as pseudoepitheliomatous hyperplasia in chronic vernal keratoconjunctivitis.
GMS ophthalmology casesDiagnosis and Treatment of Vernal Keratoconjunctivitis: A Qualitative Study of Caregiver, Patient, and Clinician Experience in the United States.
Journal of pediatric ophthalmology and strabismus[New and future treatment approaches for allergic conjunctivitis].
Die Ophthalmologie[Current aspects of vernal and atopic keratoconjunctivitis].
Die OphthalmologieBurden of Vernal Keratoconjunctivitis in the United States: A Retrospective Claims Database Analysis.
OphthalmologyAccelerated Corneal Cross-linking in Pediatric Patients with Progressive Keratoconus: 12-Month Follow-up Results.
Nigerian journal of clinical practiceVernal keratoconjunctivitis and eosinophilic esophagitis: A rare combination?
The World Allergy Organization journalVisual outcome and postoperative complications of cataract surgery in patients with ocular surface disorders.
Journal of cataract and refractive surgeryLong-Term Clinical Outcome of Tacrolimus Skin Ointment (0.03%) for the Treatment of Vernal Keratoconjunctivitis: A Quasi-Experimental Study.
CureusAre inflammation-related diseases risk factors for primary acquired nasolacrimal duct obstruction? A large scale, national case-control study.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie[Shield ulcer in vernal keratoconjunctivitis].
Die OphthalmologieA Rare Case of Non-Neurological Ptosis.
CureusOcular surface pseudoepitheliomatous hyperplasia secondary to allergic eye disease: clinical features and management.
Eye (London, England)A rare case of acute stromal rejection following deep anterior lamellar keratoplasty in a steroid responder with keratoconus and vernal keratoconjunctivitis.
Indian journal of ophthalmologyEpidemiology of Pediatric Ocular Surface Inflammatory Diseases in the United States Using the Optum Labs Data Warehouse.
OphthalmologyUsability of an Eye Drop Delivery Aid for Single-Dose Instillation: Results from a Market Research Study.
Clinical ophthalmology (Auckland, N.Z.)Axenfeld-Reiger syndrome: A search for the missing links.
World journal of clinical casesPrevalence and clinical profile of keratoconus in patients presenting at a provincial hospital in KwaZulu, Natal, South Africa: A case study.
Journal of public health in AfricaSuture-related complications after deep anterior lamellar keratoplasty for keratoconus.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieClassification of Subtypes of Vernal Keratoconjunctivitis by Cluster Analysis Based on Clinical Features.
Clinical ophthalmology (Auckland, N.Z.)Tear Tacrolimus Levels and Clinical Response After Adjunct Therapy With Cutaneous Application of Tacrolimus 0.1% Over Upper Eyelid Skin in Chronic Vernal Keratoconjunctivitis.
CorneaDendritic Cell Density and Morphology Can Be Used to Differentiate Vernal Keratoconjunctivitis from Allergic Conjunctivitis.
BiomoleculesManagement of vernal keratoconjunctivitis: Navigating a changing treatment landscape.
Survey of ophthalmologyBiomarkers of ocular allergy and dry eye disease.
Romanian journal of ophthalmologyNOVATIVE: A Phase II/III, Multicenter, Double-masked, Randomized Study of Cyclosporine A 0.05% and 0.1% Ophthalmic Cationic Emulsion Versus Vehicle in Patients with Vernal Keratoconjunctivitis.
Clinical therapeuticsEosinophil extracellular trap formation in the giant papillae of atopic keratoconjunctivitis and vernal keratoconjunctivitis.
Allergology international : official journal of the Japanese Society of AllergologyTwo cases of unilateral limbal Vernal keratoconjunctivitis in the same family: first case report.
Frontiers in pediatricsPaediatric cornea crosslinking current strategies: A review.
Advances in ophthalmology practice and researchCorrelation between gene expression and clinical scores in vernal keratoconjunctivitis.
AllergyEfficacy of a Cationic Emulsion of Cyclosporine in Moderate Vernal Keratoconjunctivitis.
CorneaVernal Keratoconjunctivitis: A Systematic Review.
Clinical reviews in allergy & immunologySafety and efficacy of topical tacrolimus 0.03% in the management of vernal keratoconjunctivitis: a non-randomized controlled clinical trial.
Medical hypothesis, discovery & innovation ophthalmology journalAssociation between keratoconus and allergic conjunctivitis in children attending a Tertiary Hospital in Nigeria.
Romanian journal of ophthalmologySurgical Treatment of Corneal Shield Ulcer in Vernal Keratoconjunctivitis: A Systematic Review.
Journal of personalized medicineImpact of Exposomes on Ocular Surface Diseases.
International journal of molecular sciencesAir Pollution and Meteorological Conditions Significantly Associated With Vernal Keratoconjunctivitis Exacerbations.
Investigative ophthalmology & visual sciencePrevalence and clinical characteristics of vernal keratoconjunctivitis in sub-Saharan Africa.
Current opinion in allergy and clinical immunologyVernal keratoconjunctivitis: Current immunological and clinical evidence and the potential role of omalizumab.
The World Allergy Organization journalRepeat deep anterior lamellar keratoplasty (DALK) for failed primary DALK.
Indian journal of ophthalmologyAre Periocular and Systemic Allergy Conditions Risk Factors for Pterygium?
Seminars in ophthalmologyDiagnostic criteria of chronic conjunctivitis: atopic keratoconjunctivitis and vernal keratoconjunctivitis.
Current opinion in allergy and clinical immunologyComparision of efficacy and safety of 0.03% and 0.1% tacrolimus ointment in children with vernal keratoconjunctivitis.
Therapeutic advances in ophthalmologyA survey-based study on diagnosis and management of vernal keratoconjunctivitis.
Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and ImmunologyVernal Keratoconjunctivitis among Patients Presenting to the Outpatient Department of Ophthalmology of a Tertiary Care Centre: A Descriptive Cross-sectional Study.
JNMA; journal of the Nepal Medical AssociationAssessment of the efficacy of olopatadine 0.1% in the treatment of vernal keratoconjunctivitis in terms of clinical improvement based on total ocular symptom score and ocular surface disease index.
Indian journal of ophthalmologyAn observational study on the presence of perilimbal conjunctival pigmentation in vernal keratoconjunctivitis.
Indian journal of ophthalmologyCyclosporine ophthalmic emulsion (Verkazia) for vernal keratoconjunctivitis.
The Medical letter on drugs and therapeuticsVernal Keratoconjunctivitis Associated with Terrien Degeneration and Intralesional Cysts.
OphthalmologyAnalysis of the outcomes of three different cross-linking protocols for treatment of paediatric keratoconus: A multicentre randomized controlled trial.
Acta ophthalmologicaArtificial intelligence-based ChatGPT chatbot responses for patient and parent questions on vernal keratoconjunctivitis.
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle OphthalmologieSplinter Cataract in Patients with Keratoconus and Frequent Eye Rubbing: A Novel Finding.
The American journal of case reportsCorneal topometric indices and proclivity toward corneal ectasia in vernal keratoconjunctivitis.
Journal francais d'ophtalmologieGalectin-3, a damage-associated molecular pattern, in tears of patients with vernal keratoconjunctivitis.
Japanese journal of ophthalmologyClinical Outcomes of Topical 0.1% Ciclosporin Cationic Emulsion Used on Label in Children with Vernal Keratoconjunctivitis.
Ophthalmology and therapyPrevalence of dry eye disease in the patients of allergic conjunctivitis: Hospital-based cross-sectional study.
Indian journal of ophthalmologyEvaluation of dry eyes in children with vernal kerato-conjunctivitis using clinical tests and ocular surface analysis.
Indian journal of ophthalmologyCharacteristics of Vernal Keratoconjunctivitis in Lhasa: A Single-Center, Observational Study.
Ocular immunology and inflammationRisk Factors Associated with Keratoconus in an Iranian Population.
Journal of ophthalmic & vision researchVernal keratoconjunctivitis in Down syndrome: a case report.
BMC ophthalmologyTear Film MicroRNAs as Potential Biomarkers: A Review.
International journal of molecular sciencesClinical Study on Corneal Topographical Changes in Vernal Keratoconjunctivitis by Using OCULUS Pentacam®.
CureusNovel Insights in the Management of Vernal Keratoconjunctivitis (VKC): European Expert Consensus Using a Modified Nominal Group Technique.
Ophthalmology and therapyIncreased dendritic cell density and altered morphology in allergic conjunctivitis.
Eye (London, England)Diagnosis and management of keratoconus by eye care practitioners in Kenya.
BMC ophthalmologyDemographic and clinical characteristics of childhood and adult onset Vernal Keratoconjunctivitis in a tertiary care center during Covid pandemic: A prospective study.
Romanian journal of ophthalmologyPractice patterns and opinions in the treatment of allergic eye disease: A survey among Indian ophthalmologists.
Indian journal of ophthalmologyRole of Oncostatin M in the Pathogenesis of Vernal Keratoconjunctivitis: Focus on the Barrier Function of the Epithelium and Interleukin-33 Production by Fibroblasts.
Investigative ophthalmology & visual scienceTopical cyclosporine A cationic ophthalmic emulsion in paediatric vernal keratoconjunctivitis: pooled analysis of randomised NOVATIVE and VEKTIS trials.
Eye (London, England)Corneal biomechanical properties in vernal keratoconjunctivitis and its subtypes: a preliminary study.
International ophthalmologyParadoxical increase in peripapillary retinal nerve fibre layer thickness during the acute phase of steroid-induced increase in intraocular pressure in a patient with vernal keratoconjunctivitis.
Acta ophthalmologicaEvaluation of corneal epithelial thickness mapping using anterior segment OCT in children with vernal keratoconjunctivitis.
International ophthalmologyA Case of Vernal Keratoconjunctivitis With Growth Hormone Deficiency.
CureusEvaluation of the factors that influence surgical outcome in conjunctival-limbal allograft transplantation.
Eye (London, England)Tissue remodeling in adult vernal keratoconjunctivitis.
Experimental eye researchBiologics for allergy: therapeutic potential for ocular allergic diseases and adverse effects on the eye.
Allergology international : official journal of the Japanese Society of AllergologyEfficacy and Safety of 0.1% Cyclosporine versus 2% Cyclosporine in the Treatment of Severe Vernal Keratoconjunctivitis in Children.
Clinical ophthalmology (Auckland, N.Z.)Efficacy of single dose dermatological 0.1% Tacrolimus Ointment in the treatment of vernal keratoconjunctivitis.
JPMA. The Journal of the Pakistan Medical AssociationOcular surface characteristics in pediatric vernal keratoconjunctivitis: a clinico-cytological study.
Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and StrabismusThe effect of COVID-19 imposed lockdown on Italian children with Vernal Keratoconjunctivitis.
The World Allergy Organization journalExecutive summary: Japanese guidelines for allergic conjunctival diseases 2021.
Allergology international : official journal of the Japanese Society of AllergologyThe multifaceted aspects of ocular allergies: Phenotypes and endotypes.
The ocular surfaceAnalysis of Cytokine Production Profiles of Local and Systemic Lymphocytes in Sick Building Syndrome Compared with Ocular Allergy.
Journal of asthma and allergyImpression Cytology Screening for Ocular Surface changes in various forms of Vernal Keratoconjunctivitis in Subtropical Central Zone in India.
Nepalese journal of ophthalmology : a biannual peer-reviewed academic journal of the Nepal Ophthalmic Society : NEPJOPHDiagnosis, Management, and Treatment of Vernal Keratoconjunctivitis in Asia: Recommendations From the Management of Vernal Keratoconjunctivitis in Asia Expert Working Group.
Frontiers in medicineEmerging therapies targeting eosinophil-mediated inflammation in chronic allergic conjunctivitis.
The ocular surfaceEffect of Anti-allergic Therapy on Quality of Life in Children with Allergic Conjunctivitis and Their Parents.
Ocular immunology and inflammationEfficacy and Satisfaction of Cyclosporine 0.1% in Patients with Vernal Keratoconjunctivitis.
Ocular immunology and inflammationEffects of Antihistamine-Releasing Contact Lenses on Severe Allergic Conjunctivitis.
Ocular immunology and inflammationSuccessful treatment and prevention of the recurrence of refractory vernal keratoconjunctivitis with dupilumab.
Clinical & experimental ophthalmologyConjunctival granuloma in vernal keratoconjunctivitis.
Journal francais d'ophtalmologieCyclosporine A 0.1% Cationic Emulsion in Vernal Keratoconjunctivitis.
Journal of pediatric ophthalmology and strabismusEvidence of epithelial remodelling but not epithelial-mesenchymal transition by transcriptome profiling in vernal keratoconjunctivitis.
AllergyPrevalence of allergic sensitization with vernal keratoconjunctivitis: A systematic review with meta-analyses.
Acta ophthalmologica[PHARMACOTHERAPY FOR VERNAL KERATOCONJUNCTIVITIS].
Arerugi = [Allergy]Combination Therapy of 0.1% Fluorometholone and 0.05% Azelastine in Eyes with Severe Allergic Conjunctival Diseases: A Randomized Controlled Trial.
Journal of clinical medicineEffectiveness of a modified therapeutic protocol for the management of vernal keratoconjunctivitis based on Bonini's graded clinical severity.
Indian journal of ophthalmologyProgressive Vision Loss in a Patient With Axenfeld-Rieger Syndrome.
CureusOcular allergy in children and adolescents.
Allergologia et immunopathologiaManagement of Vernal Keratoconjunctivitis in Children in the United Kingdom: A Review of the Literature and Current Best Practice Across Six Large United Kingdom Centers.
Journal of pediatric ophthalmology and strabismusImpact of screen exposure on pediatric vernal Keratoconjunctivitis: a survey during the COVID-19 pandemic in Italy.
Italian journal of pediatricsExamination of corneal microstructure in the quiescent phase of vernal keratoconjunctivitis using in vivo confocal microscopy.
European journal of ophthalmologyProfile of ocular conditions from school eye screening in Southern India.
Indian journal of ophthalmologyAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Ceratoconjuntivite primaveril.
É de uma associação que acompanha esta doença? Fale com a gente →
Comunidades
Grupos ativos de quem convive com esta doença aqui no Raras
Ainda não existe comunidade no Raras para Ceratoconjuntivite primaveril
Pacientes, familiares e cuidadores se organizam em comunidades pra compartilhar experiências, fazer perguntas e se apoiar. Você pode ser o primeiro.
Tire suas dúvidas
Perguntas, dicas e experiências compartilhadas aqui na página
Participe da discussão
Faça login para postar dúvidas, compartilhar experiências e interagir com especialistas.
Fazer loginDoenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Enigmatic Role of IL-31 in the Itch and Inflammation of Vernal Keratoconjunctivitis.
- Effectiveness of Corticosteroid-Sparing Topical Treatments for Vernal Keratoconjunctivitis in Children: A Report by the American Academy of Ophthalmology.
- Changing Strategies in Keratoplasty After Corneal Hydrops: From Penetrating to Lamellar Approaches - A Narrative Review.
- Corneal collagen cross-linking at diagnosis in pediatric keratoconus: A prospective study from the Indian Subcontinent.
- Factors associated with graft astigmatism after corneal transplantation for keratoconus.
- Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases.
- A red-eye presentation concerning for vernal keratoconjunctivitis: a case report.
- Ultraviolet association with vernal keratoconjunctivitis with perilimbal pigmentation.
- Treatment of vernal keratoconjunctivitis simulating total limbal stem cell deficiency: a case report.
- Pediatric Vernal Keratoconjunctivitis (VKC): Current State and Future Directions-A Narrative Review of Clinical Features, Diagnostic Strategies, and Emerging Therapies.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:70476(Orphanet)
- MONDO:0019085(MONDO)
- GARD:7854(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q3686833(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
