Lesões da córnea, com deficiência associada a células-tronco da córnea (limbo), por queimaduras oculares

Study to Evaluate the Safety and Efficacy of CSB-001 Ophthalmic Solution 0.1% in Subjects With Limbal Stem Cell Deficiency

NCT06452316

Cultured Autologous Oral Mucosa Epithelial Sheet for the Treatment of Bilateral Limbal Stem Cell Deficiency

Fase II

NCT03949881

Association Between Limbal Function and Tear Proteomics in Chronic Ocular Diseases: Focusing on Glaucoma

NCT07119580

Autologous Cultured Corneal Epithelium (CECA) for the Treatment of Limbal Stem Cell Deficiency

NCT01756365

Implementation of a Protocol for the Transdifferentiation of Buccal Mucosal Epithelium Into Corneal Epithelium

NCT06265298

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NCT03949881 · Cultured Autologous Oral Mucosa Epithelial Sheet for the Tre…Recrutando

NCT07119580 · Association Between Limbal Function and Tear Proteomics in C…Recrutando

NCT01756365 · Autologous Cultured Corneal Epithelium (CECA) for the Treatm…Recrutando

NCT06265298 · Implementation of a Protocol for the Transdifferentiation of…Recrutando

NCT04995926 · Labial Mucosal Epithelium Grafting for Corneal Limbus Substi…Recrutando

NCT03957954 · Stem Cell Therapy for Limbal Stem Cell DeficiencyAtivo

Outros ensaios clínicos

41 ensaios clínicos encontrados, 9 ativos.

Distribuição por fase

NCT03884569 · Cultivated Limbal Epithelial Transplantation (CLET) for Limb…Em breve

NCT06412718 · Validation of Human Drugs Target of Repurposed Drugs and Nov…Em breve

NCT07422389 · BRM421 Ophthalmic Solution in Patients With Limbal Stem Cell…AVAILABLE

NCT05909735 · Treatment of LSCD With DMConcluído

NCT02318485 · Limbal Epithelial Stem Cell Transplantation: a Phase II Mult…Concluído

PHASE2

NCT02592330 · Limbal Stem Cell Deficiency (LSCD) Treatment With Cultivated…Concluído

NCT05461469 · CDL Validation StudyConcluído

NCT03288844 · Follow-up Study After ACLSCT for Restoration of Corneal Epit…Concluído

NCT03549299 · Allogeneic ABCB5-positive Limbal Stem Cells for Treatment of…UNKNOWN

NCT02577861 · Efficacy and Safety of Autologous Cultivated Limbal Stem Cel…Concluído

PHASE4

NCT03943797 · Cultivated Autologous Oral Mucosal Epithelial Transplantatio…UNKNOWN

NCT03217435 · Corneal Epithelial Allograft From Living-related Donor for L…Concluído

NCT02415218 · Transplantation of Autologous Oral Mucosal Epithelial Sheets…Concluído

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

948 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 948

#1

Endogenous Therapeutic Agents for Acute Corneal and Ocular Surface Injuries.

Translational vision science & technology2026 Mar 02

Acute corneal injuries vary greatly in morbidity, but can cause severe cases of vision loss. Among these injuries are mechanical corneal traumas and acute chemical burns. The current standard of care in the acute phase of management is aimed at reducing the offending agent, pain management, and infection prevention; however, corneal scarring and limbal stem cell deficiency may result even after the acute management of severe corneal injuries. In the most serious cases, surgical intervention, including cornea or stem cell transplantation, may be required to restore functional vision. As such, there is a great need for additional therapies in the acute phase of management that can help to reduce long-term, vision-reducing outcomes. Certain endogenous agents have emerged as a therapeutic class that may be used for the promotion of corneal wound healing with the goal of reducing the odds of requiring invasive surgery. In this review, we provide an overview of novel endogenous therapeutic agents for the treatment of acute corneal trauma and acute chemical burns. The endogenous therapeutic agents explored include amnion, exosomes, stem cells, platelet-rich plasma, peptides, growth factors, and umbilical cord serum. The results of these studies indicate encouraging potential for endogenous agents to facilitate corneal recovery and vision preservation. However, because many of these agents are in the early stages of development and clinical trials, further research is required to understand their efficacy in the clinical setting.

#2

Repair of Corneal Epithelial Defects.

Progress in molecular and subcellular biology2026

The corneal epithelium, a stratified squamous non-keratinized layer of 50-60 μm thickness, forms the outermost barrier of the cornea and provides both optical clarity and protection against trauma, infection, and fluid imbalance. It plays a vital role in protecting the eye and maintaining visual clarity. A range of conditions, including trauma, metabolic disorders, microbial infection, and limbal stem cell deficiency, can lead to chronic corneal epithelial defects and subsequent visual impairment. Epithelial renewal is a continuous process, primarily sustained by stem cells located at the limbus. These stem cells give rise to transient amplifying cells, which migrate centripetally and superficially to maintain epithelial integrity. Wound healing follows a highly regulated sequence, superficial cells slide to cover the defect, basal cells proliferate, and corneal nerves realign to support epithelial stratification. This process is orchestrated by cytoskeletal remodeling, integrin-matrix interactions, and growth factor signaling. The epithelium relies on glucose from the corneal stroma, primarily metabolized through glycolysis, while mitochondrial oxidative phosphorylation generates the ATP required for repair. Thus, epithelial regeneration is closely tied to cellular energy availability. Enhancing this process involves supporting mitochondrial function, metabolic signaling pathways, and stem cell activity. Emerging strategies in regenerative ophthalmology include NAD+ replenishment, activation of AMP-activated protein kinase (AMPK), application of growth factors, targeted nanotherapies, and photobiomodulation. This chapter explores these cutting-edge approaches aimed at promoting energy-driven regeneration of the corneal surface.

#3

In situ spatial transcriptomics reveals novel markers of the limbal stem cell niche and ocular surface epithelia.

Stem cell reports2026 Mar 10

The mammalian cornea is endowed with stem cells (SCs) that have lifelong regenerative activity. The niche for these cells is the limbus, and damage to it or its SCs results in limbal stem cell deficiency (LSCD). Despite the numerous studies that employ single-cell RNA sequencing, the identity of these cells remains an enigma principally because their spatial positioning is lost upon dissociation. These adversities were avoided via on-tissue spatial transcriptomics where Krt16 and Nkiras1 were differentially expressed. Krt16 was dynamically expressed in the developing limbus, correlated with slow-cycling label-retaining limbal epithelial SCs and was induced during corneal injury, observations consistent with marking functional SCs. Additionally, we established Nkiras1 as a novel maker of limbal neutrophils. Because current gold-standard treatments for LSCD include SC transplantation, our data will inform future studies in delivering a more reliable standard therapy that incorporates an identifiable SC population to improve clinical outcomes.

#4

PAX6 Deficiency Compromises the Ability of Limbal Epithelial Stem Cells to Properly Differentiate Into Mature Corneal Epithelial Cells.

Investigative ophthalmology & visual science2026 Jan 05

Aniridia, driven by PAX6 mutations, causes aniridia-associated keratopathy (AAK), a progressive condition linked to limbal stem cell deficiency. A major hurdle to developing targeted therapies for AAK is the incomplete understanding of the molecular abnormalities in affected corneas. To address this, we leveraged Pax6± (Pax6 het) mice, a model of AAK, and applied single-cell RNA sequencing (scRNA-seq) to profile the transcriptomic changes at a single-cell resolution. ScRNA-seq of corneal/limbal tissues of wild type (WT) and Pax6 het mice were conducted. Immunostaining was performed to examine the expression of specific markers for stem cells. ScRNA-seq identified a quiescent limbal epithelial stem cell (LESC)-like cell cluster and an early transient amplifying cell (eTAC)-like cluster. An increase in the cell numbers in these two clusters in the Pax6 het mouse corneas was observed. Immunostaining detected a marked increase in markers for these two clusters including Tmem176b, Apoe, and Krt15 in the corneal epithelium of Pax6 het mice, suggesting an increase of these LESC/eTA-like cells into the corneal epithelium. The Pax6 deficiency inhibited the expression of genes involved in cell proliferation in the eTAC-like cluster as well as the expression of genes related to corneal epithelial cell fate and differentiation compared with WT mice. Our single cell transcriptome of the limbus and cornea of Pax6 het mice indicates that AAK may be due to the increase of dysfunctional stem/eTACs with defects in committing to a corneal epithelial cell fate and differentiation.

#5

Losartan Alleviates Chemical Burn-Induced Limbal Stem Cell Deficiency: Repurposing a Venerable Anti-Hypertension Drug.

Investigative ophthalmology & visual science2026 Jan 05

Currently, treatment for limbal stem cell deficiency (LSCD) involves limbal stem cell transplantation using either autologous or allogeneic tissue to restore the corneal surface. However, limitations such as donor shortages, immune rejection, and variable outcomes highlight a crucial need for more effective and safer therapeutic options. We utilized a nitrogen mustard (NM)-induced corneal injury model to create LSCD, characterized by conjunctivalization. Mice exposed to NM were intraperitoneally injected with losartan. Single cell RNA sequencing (scRNA-seq) was conducted using a 10X Genomics platform. Previously, we demonstrated that corneal inflammation can be reversed by treatment with losartan, a widely used anti-hypertension drug with established long-term safety. Here, we demonstrate that systemic treatment with losartan markedly decreased corneal haze and inflammation during the acute and delayed phases of NM corneal injury. In the delayed phase, losartan treatment reduced NM-induced neovascularization in the cornea. Goblet cells detected within the corneal epithelium (conjunctivalization) during the delayed phase were significantly reduced following losartan treatment, indicating that losartan significantly resolves this classical hallmark of LSCD. The scRNA-seq showed that NM injury induced a dramatic increase in monocytes/macrophages in the cornea and that such an increase was attenuated by losartan treatment. Flow cytometry analysis confirmed that losartan attenuated corneal inflammation via reducing the monocytes/macrophages in the cornea. Our findings strongly support a new therapeutic use for losartan in blunting LSCD, which is a consequence associated with numerous corneal inflammatory conditions (e.g. diabetic keratopathy and tear gland insufficiency).

Publicações recentes

Melanocytes as key cells of the limbal stem cell niche: Roles in ocular surface homeostasis, disease, and regenerative therapy.

Ocul Surf2026 Apr 7

Descemet Membrane Anterior Keratoplasty With BrightMEM Corneal Allograft: An Innovative Technique for Treatment of Nonhealing Diseases of the Ocular Surface.

Cornea2026 Mar 17

Treatment of vernal keratoconjunctivitis simulating total limbal stem cell deficiency: a case report.

BMC Ophthalmol2026 Mar 30

Transparent GelMA biomaterials: Advanced solutions for ocular tissue engineering and regenerative ophthalmology.

Adv Ophthalmol Pract Res2026 May-Jun

Anterior Segment Optical Coherence Tomography with Angiography for the Cornea and Ocular Surface.

J Clin Med2026 Mar 21

Ver todas no PubMed

📚 EuropePMC444 artigos no totalmostrando 194

Translational vision science & technology

Endogenous Therapeutic Agents for Acute Corneal and Ocular Surface Injuries.

Implementing stem-cell therapies for limbal stem cell deficiency.

Regenerative medicine

Life (Basel, Switzerland)

Altered Ocular Surface Temperature in Congenital Aniridia with PAX6 Pathogenic Variants: Impact of Age, Salzmann Nodules and Ocular Surgery.

Journal of ophthalmic inflammation and infection

Emerging zoonotic ocular sporotrichosis in southeast Asia: a case series from Thailand and systematic review of regional reports.

Progress in molecular and subcellular biology

Repair of Corneal Epithelial Defects.

AMIA ... Annual Symposium proceedings. AMIA Symposium

Automated Image Registration Method for In Vivo Confocal Microscopy of the Corneal Sub-basal Nerve Plexus.

Exploring the impact of human pluripotent stem cell heterogeneity on corneal limbal stem cell differentiation outcomes.

Australasian consensus recommendations on stem cell therapies for managing ocular surface diseases.

Journal of clinical medicine

Cultivated Oral Mucosal Epithelial Transplantation for Limbal Stem Cell Deficiency: A Scoping Review of Indications, Platforms, Outcomes and Safety.

In situ spatial transcriptomics reveals novel markers of the limbal stem cell niche and ocular surface epithelia.

Stem cell reports

Efficacy of Cultivated Oral Mucosal Epithelial Transplantation for Limbal Stem Cell Deficiency in Stevens-Johnson Syndrome Versus Other Etiologies.

Association Between Neurotrophic Keratitis and Limbal Stem Cell Deficiency.

PAX6 Deficiency Compromises the Ability of Limbal Epithelial Stem Cells to Properly Differentiate Into Mature Corneal Epithelial Cells.

The Role of the Boston Keratoprosthesis in Severe Ocular Surface Disease and Autoimmune Diseases.

Corneal macrophages and limbal stem cells: emerging roles in ocular surface regeneration.

Annals of medicine

Losartan Alleviates Chemical Burn-Induced Limbal Stem Cell Deficiency: Repurposing a Venerable Anti-Hypertension Drug.

Letter to Editor: Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns.

Limbal Epithelial Stem Cells in Review: Immune and Lymphangiogenic Privilege and Their Clinical Relevance.

Cells

Impact of Smoking on the Efficacy of Human Autologous Oral Mucosal Epithelial Cell Sheet Transplantation for Treating Limbal Stem Cell Deficiency.

Stem cells international

Generation of a Bioengineered Substitute of the Human Sclero-Corneal Limbus Using a Novel Decellularization Method.

Pharmaceutics

Journal of clinical medicine

Outcome of Allogeneic Penetrating Limbo-Keratoplasty: A Single-Center Retrospective Cohort Study.

Development of a microscopy-based diagnostic test for alkali injury-induced limbal stem cell deficiency through Autofluorescence Multispectral Imaging.

Turkish journal of ophthalmology

Clinical Outcomes of Different Surgical Techniques in Limbal Stem Cell Deficiency.

Multimodal objective assessment of a porcine limbal stem cell deficiency model for corneal therapy research.

Limbal Vascular Regrowth After Ocular Surface Chemical Injuries: Imaging by Anterior Segment Optical Coherence Tomography Angiography.

Chronic Ocular Complications in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Clinical Features and Surgical Management in a Brazilian Tertiary Center.

Descemet Membrane Versus Amniotic Membrane for Limbal Stem Cell Therapy.

Long-Term Outcomes of Boston Type I Keratoprosthesis After Minor Salivary Gland Transplantation and Labial Mucous Membrane Grafting as an Alternative Treatment for Stevens-Johnson Syndrome.

Advancements in Cellular Therapeutics in Corneal Diseases.

Cells

Current Landscape and Future Prospects of Corneal Regenerative Medicine.

Limbal Epithelial Cells Detected in Stage III Limbal Stem Cell Deficiency by Multimodal Anterior Segment Imaging.

Mechanistic insights into conjunctivalization in limbal stem cell deficiency using a lineage tracing approach.

Bioengineering (Basel, Switzerland)

Corneal Epithelial Tissue Engineering Strategy Based on Cell Viability Optimization: A Review and Prospects.

Ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis: A review of current management and changing trends.

The efficacy of bone marrow-derived mesenchymal stem cells in restoring limbal stem cell deficiency in rat model.

Outcome of Cenegermin in the Treatment of Neurotrophic Keratopathy.

Demographics, Prevalence, and Characteristics of Limbal Stem Cell Deficiency in Southern California.

Double Layered 9-mm Dehydrated Amniotic Membrane Disc in Ocular Surface Disorders: A Case Series.

Bone marrow-versus adipose tissue-derived mesenchymal stem cells for corneal failure in an experimental model of limbal stem cell deficiency.

[Short-term outcomes of corneal epithelial reconstruction in patients with bilateral limbal stem cell deficiency using paralimbal oral mucosal epithelial transplantation].

Vestnik oftalmologii

Life (Basel, Switzerland)

Applications of Modern Cell Therapies: The Latest Data in Ophthalmology.

Topical 5-fluorouracil 1% versus surgical removal as a primary treatment modality for ocular surface squamous neoplasia: a comparison of recurrences and side effects.

BMC ophthalmology

Medical hypothesis, discovery & innovation ophthalmology journal

Clinical anatomy: cornea and ocular surface.

Limbal stem cell sheet bandage for short-term treatment of corneal regeneration.

BMC ophthalmology

Veterinary research communications

Therapeutic effects of adipose mesenchymal stem cell-derived exosomes on limbal stem cells deficiency in cats.

Topical Chemotherapy for Ocular Surface Squamous Neoplasia: A Review of Adverse Effects and Their Clinical Management.

Oncology research

Repairing Effect and Mechanism of the 4-Dimensionally Printed Limbal Stem Cell Strategy on Corneal Alkali Burns in Large Animals.

Biomaterials research

Clinical Outcomes of Keratolimbal Allograft Transplantation With Oral Mucosal Transplantation for Limbal Stem Cell Deficiency With Symblepharon.

Stem cells international

Clinical outcomes of simple limbal epithelial transplantation for limbal stem cell deficiency in a Mexican population.

Taiwan journal of ophthalmology

Development of a high-resolution three-dimensional optical coherence tomography for characterization of epithelial cell products for corneal cell therapy.

Limbal stem cell deficiency secondary to vitrectomy in the context of an autoimmune polyendocrine syndrome type.

Clinical & experimental optometry

The role of limbal stem cells on neurotrophic cornea.

Clinical ophthalmology (Auckland, N.Z.)

Outcomes of Collagen Crosslinking in Patients with Keratoconus and Co-Existent Limbal Stem Cell Deficiency.

[Autologous oral mucosal epithelial transplantation in the treatment of bilateral limbal stem cell deficiency].

Vestnik oftalmologii

Therapeutic advances in ophthalmology

Topical erythropoietin in the management of scleral necrosis: a narrative review.

IVCM image analysis for limbal stem cell deficiency: quantitative diagnostics of the corneal epithelium post-transplant recovery.

Surgical Management of Corneal Sequelae of Vernal Keratoconjunctivitis.

Ocular Complications in stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Comprehensive Review.

Challenges in Managing the Ocular Complications of Stevens-Johnson Syndrome in Patients with Co-Existent Auto-Immune Disease.

Chronic Ocular Sequelae of Stevens-Johnson Syndrome: Recent Advances in Understanding of Patho-Physiology and Management.

Finger's continuous bipedicle conjunctival flap.

Corneal surface reconstruction for the chemical injured eye by transplanting autologous cultivated limbal epithelial sheet "Nepic®".

Fujita medical journal

Modified Simple Limbal Epithelial Transplant for the Treatment of Symblepharon in Cats: A Pilot Study.

Veterinary ophthalmology

Bioengineering (Basel, Switzerland)

Different Expression of Vascularization and Inflammatory Regulators in Cells Derived from Oral Mucosa and Limbus.

Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns.

Microbial Keratitis in Ocular Surface Disease.

Decade-Long Follow-Up of Autologous Simple Limbal Epithelial Transplantation in Pediatric Patients With Unilateral Chemical Injury: A Case Series.

Vision (Basel, Switzerland)

Novel Surgical Approach for Limbal Dermoid Excision: Utilizing Bowman's Membrane Lenticule and Autologous Limbal Stem Cell Transplantation for Enhanced Epithelial Healing and Visual Outcomes.

Japanese journal of ophthalmology

Corneal irregularity of the anterior and posterior surface in patients with limbal stem cell deficiency evaluated with anterior-segment optical coherence tomography.

Assessment of the official national insurance coverage of regenerative medical products for ophthalmic diseases in Japan following regulatory approval.

Regenerative therapy

Oman journal of ophthalmology

Corneal melting following intrastromal injection of bevacizumab for corneal neovascularization.

Stem cells (Dayton, Ohio)

Clinical evidence and critical review of mesenchymal stromal cells for corneal and ocular surface diseases.

Autologous Glueless Simple Limbal Epithelial Transplantation for Unilateral Stem Cell Deficiency Using Femtosecond Laser-Assisted Limbal Stem Cell Harvesting: The Report of the First 3 Clinical Cases.

Mymensingh medical journal : MMJ

Annular Conjunctival Autograft (ACAU): Modified Technique for Ocular Surface Reconstruction in Unilateral Chemical Burn.

DNA damage in oral mucosal epithelial cells cultured in complex and xenobiotic-free media: a comparison study.

Mutagenesis

Symblepharon: A Review of Etiology, Clinical Features, and Management Strategies.

Insights Into the Pathophysiology of Superior Limbic Keratoconjunctivitis in Chronic Ocular Graft-Versus-Host Disease.

The British journal of ophthalmology

International corneal and ocular surface disease dataset for electronic health records.

Stevens-Johnson Syndrome as a Risk Factor for Ocular Surface Squamous Neoplasia in a Pediatric Patient.

Vernal Keratoconjunctivitis: Impact on Children.

Outcomes in Acute Ocular Surface Chemical Injury-Role of pH Measurement on Presentation: A Retrospective Cohort Study.

Journal of controlled release : official journal of the Controlled Release Society

Topical delivery of cultivated limbal stem cells via porous photocurable hydrogel: A noninvasive, convenient, and efficient stem cells delivery strategy for limbal stem cell deficiency.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Chirality Regulates Stem Cell Fate and Promotes Corneal Epithelial Regeneration via Manipulating Notch Pathway.

Oxford medical case reports

Limbal stem cell deficiency: a dreaded complication of chickenpox in children.

Treatment Options for Alkali Burn-Induced Corneal Neovascularization: A Comparative Analysis of Two Tyrosine Kinase Inhibitors.

Safety of subconjunctival injection of mesenchymal stromal cells in persistent corneal epithelial disease - A phase 1b clinical trial.

Optimizing Keratolimbal Allograft Outcomes: Optical Coherence Tomography Analysis of Donor Graft Phenotypes in Limbal Stem Cell Deficiency.

Stem cell reviews and reports

Amniotic Membrane Transplantation for Wound Healing, Tissue Regeneration and Immune Modulation.

Iatrogenic Ocular Surface Complications After Surgery for Ocular and Adnexal Tumors.

Cancers

Temporal Differences in the Expression of p63α and Proliferation of Limbal Epithelial Stem Cells From Donor Corneas.

[Nonpenetrating surgical approaches to promote corneal homeostasis].

Die Ophthalmologie

Cultivated Autologous Limbal Epithelial Cell Transplantation: A Review of Clinical Trials and Applications.

Current stem cell research & therapy

Multiple Stem/Progenitor Cells Isolated from the Limbus.

Management of Intraocular Pressure Elevation After Commercially Available Cultivated Oral Mucosal Epithelial Cell Transplantation for Limbal Stem Cell Deficiency.

A Case-Based Approach to the Management of Corneal Melts and Perforations in Ocular Surface Disorders.

Stem cell reviews and reports

Can Stem Cell Therapy Revolutionize Ocular Disease Treatment? A Critical Review of Preclinical and Clinical Advances.

Vision (Basel, Switzerland)

Emerging Treatments for Persistent Corneal Epithelial Defects.

Limbal explant cultures on amniotic membrane: The effects of passaging the explants on cell phenotype.

Ocular surface squamous neoplasia masquerades: Clinical profile and outcome.

Visual Outcomes of Limbal Stem Cell Transplantation in the IRIS® Registry.

Ophthalmology

PAX3 expression patterns in ocular surface melanocytes.

Demographics of Limbal Stem Cell Deficiency: A Literature Review.

Immunological and histopathological changes in alkali burn-induced ocular surface pannus: Implication on success vs. failure of SLET.

Limbal Stem Cell Deficiency Induced by Prolonged Use of Topical 0.03% Tacrolimus Ointment in a Patient With Atopic Keratoconjunctivitis.

Colloids and surfaces. B, Biointerfaces

Decellularized human amniotic member hydrogel promotes limbal stem cells proliferation.

Autologous glueless simple oral mucosal transplantation for the repair of limbal stem cell deficiency ocular surface in a rabbit model.

Central Cornea Changes on Anterior Segment OCT and In Vivo Confocal Microscopy After Autologous Limbal Epithelial Cell Transplantation.

Advancing Bilateral Limbal Deficiency Surgery: A Comprehensive Review of Innovations with Mucosal Cells.

Biomedicines

Risk Factors for Development of Limbal Stem Cell Deficiency After Acute Ocular Burns.

Current eye research

Unpacking VKC: How gender and age shape the clinical picture.

Preferred practice guidelines and narrative review on infectious keratitis in ocular surface diseases.

Limbal stem cell deficiency approaches and limbal niche restoration.

Advances in experimental medicine and biology

Advances in Regenerative Medicine, Cell Therapy, and 3D Bioprinting for Corneal, Oculoplastic, and Orbital Surgery.

NPJ Regenerative medicine

A novel therapy to ameliorate nitrogen mustard-induced limbal stem cell deficiency using lipoprotein-like nanoparticles.

Adjuvant Brachytherapy Using Iodine-125 Plaques for Conjunctival Melanoma with Scleral Invasion.

Timeframe to Keratoplasty After Ocular Surface Stem Cell Transplantation.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Mineralocorticoid receptor antagonism improves corneal integrity in a rat model of limbal stem cell deficiency.

Interferon alpha-2b versus 5-fluorouracil as primary treatment modalities for ocular surface squamous neoplasia: a study of 116 eyes.

Sludging: A Postoperative Clinical Finding After Ocular Surface Stem Cell Transplantation.

Cultivated autologous limbal epithelial cell (CALEC) transplantation for limbal tem cell deficiency: a phase I/II clinical trial of the first xenobiotic-free, serum-free, antibiotic-free manufacturing protocol developed in the US.

Nature communications

Orbit (Amsterdam, Netherlands)

Adjunct botulinum toxin for cicatricial pemphigoid.

Frontiers in public health

Clinical efficacy and safety of proton radiotherapy for ocular conjunctival malignancies: a systematic review and meta-analysis.

Cultivation and characterization of oral mucosal epithelial cells on fibrin gel in a xenobiotic-free medium for the treatment of limbal stem cell deficiency.

Bibliometric and Visual Analysis of the Status of Scleral Lens Research Based on the Web of Science Database and Scopus Database (2014-2024).

Clinical optometry

Delayed Periocular and Anterior Segment Complications Following Locally Administered Chemotherapy for Vitreous Seeding in Retinoblastoma.

Stiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation.

Journal francais d'ophtalmologie

The watchmaker's eye: Exposure keratopathy with secondary limbal stem cell deficiency due to the use of a loupe.

Unveiling the Molecular Mechanisms Underlying the Success of Simple Limbal Epithelial Transplantation (SLET).

Cells

Clinical & experimental optometry

In vivo confocal microscopy in ophthalmology: research trends from a bibliometric analysis.

Five- to Twelve-Year Outcomes of Autologous Simple Limbal Epithelial Transplantation: Long-Term Corneal Epithelial Imaging and Phenotypic Analysis.

European journal of ophthalmology

Dual lamellar keratoplasty combined with phacoemulsification and intraocular Lens implantation in a case of severe chemical burn.

Dexamethasone mitigates sulfur mustard-induced stem cell deficiency in vivo in rabbit limbal tissue by reducing inflammation and oxidative stress.

Archives of toxicology

Use of an Eyelid Pressure Patch Concomitantly with a Decellularized Dehydrated Amniotic Membrane for Ocular Surface Disease Management.

Topical application of amniotic membrane extract at a clinically correlated dose is effective in limiting complications in an experimental ocular alkaline burn model.

Frontiers in ophthalmology

Diagnostic approach to limbal stem cell deficiency.

Thermal ocular burns and evaluation of associated limbal stem cell deficiency in the light of global consensus.

The British journal of ophthalmology

Insights from 1096 clinical cases: pioneering a universal grading system for vernal keratoconjunctivitis management.

International journal of molecular sciences

Biomedical Application of MSCs in Corneal Regeneration and Repair.

Classification and treatment approach of chemical burn associated Limbal stem cell deficiency: based on novel global consensus.

Femtosecond laser-assisted large-diameter lamellar corneal-limbal keratoplasty in ocular chemical burns.

Seroma under the amniotic membrane following simple limbal epithelial transplantation.

BMJ case reports

Rho kinase inhibitor Y-27632 and dual media culture approach promote the construction and transplantation of rabbit limbal epithelial cell sheets via cell spheroid culture and auto-bioprinting.

Acta biomaterialia

3D printed biomimetic bilayer limbal implants for regeneration of the corneal structure in limbal stem cell deficiency.

Acta biomaterialia

Oral Cyclosporine in Vernal Keratoconjunctivitis: Indications, Outcomes, and Effect on Corticosteroid Use.

Eccentric Superficial Anterior Lamellar Keratoplasty for Bilateral Limbal Stem Cell Deficiency.

Life (Basel, Switzerland)

Development of Biomimetic Substrates for Limbal Epithelial Stem Cells Using Collagen-Based Films, Hyaluronic Acid, Immortalized Cells, and Macromolecular Crowding.

RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway.

Allogenic Cultured Limbal Epithelial Transplantation and Cultivated Oral Mucosal Epithelial Transplantation in Limbal Stem Cells Deficiency: A Comparative Study.

Ophthalmic plastic and reconstructive surgery

Acquired Ankyloblepharon Correction Using Ocular Surface and Tarsal Mucous Membrane Grafting in Cicatrizing Ocular Surface Diseases.

Advances in the Diagnosis and Management of Limbal Stem Cell Deficiency.

Effect of Cryoprotectants on Long-Term Storage of Oral Mucosal Epithelial Cells: Implications for Stem Cell Preservation and Proliferation Status.

Folia biologica

Autologous simple limbal stem cell transplantation with conjunctival autograft in chronic unilateral total LSCD with severe symblepharon due to severe alkali burn.

BMJ case reports

Journal of visualized experiments : JoVE

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures.

Clinical & experimental optometry

Current and emerging strategies for the manufacture, implantation, and clinical management of corneal tissue allografts.

Intraocular use of methotrexate (MTX) for the treatment of proliferative vitreoretinopathy (PVR) in congenital aniridia (CI) and a possible link to aniridia fibrosis syndrome (AFS) treatment.

TNF-α Suppression Attenuates Limbal Stem Cell Damage in Ocular Injury.

A human-like model of aniridia-associated keratopathy for mechanistic and therapeutic studies.

JCI insight

Clinical and surgical outcomes of tectonic corneal patch grafts : insights from a tertiary referral hospital.

BMC ophthalmology

Multimodal Imaging Findings in Limbal Stem Cell Deficiency due to Hydroxyurea.

Ophthalmology

Biology and medicine on ocular surface restoration: Advancements and limits of limbal stem cell deficiency treatments.

Concurrent Limbal Stem Cell Deficiency and Mild Neurotrophic Keratopathy in Graft-Vs-Host Disease.

Proliferation and differentiation of Wharton's jelly-derived mesenchymal stem cells on prgf-treated hydrogel scaffold.

Regenerative medicine

Induced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan.

Lancet (London, England)

Enhancing Ex Vivo Limbal Epithelial Cell Expansion on Amniotic Membrane: A Comparative Study of Monolayer (2D) Versus Sandwich (3D) Culture Configurations.

Stem cell reviews and reports

Progress in Transdifferentiation of Autologous Alternative Cell Sources into Corneal Epithelial Cells.

Donor Tissue Preservation Time Impact on Keratolimbal Allograft Outcomes.

European journal of ophthalmology

Pediatric limbal stem cell deficiency: An overview of a rarely studied pathology.

bioRxiv : the preprint server for biology

A limbal stem cell deficiency murine model with residual limbal stem cells.

Turkish journal of ophthalmology

Evaluation of Medically Reversible Limbal Stem Cell Deficiency.

Medicina (Kaunas, Lithuania)

Anterior Segment Optical Coherence Tomography Angiography: A Review of Applications for the Cornea and Ocular Surface.

International journal of molecular sciences

Molecular and Cellular Mechanisms of the Therapeutic Effect of Mesenchymal Stem Cells and Extracellular Vesicles in Corneal Regeneration.

Simple limbal epithelial transplantation versus cultivated limbal epithelial transplantation in ocular burns.

"En bloc" combined 270-degree keratolimbal allograft with central lamellar keratoplasty for severe limbal stem cell deficiency secondary to mustard gas exposure.

Surgical Technique for Oral Mucosa Harvesting in Autologous Cultivated Oral Mucosal Epithelial Cell Transplantation for Ocular Surface Disorders.

Bio-printing method as a novel approach to obtain a fibrin scaffold settled by limbal epithelial cells for corneal regeneration.

Visual outcomes of primary keratoprosthesis implantation in transplant-naïve eyes.

PloS one

Challenging corneal diseases and microRNA expression: Focus on rare diseases and new therapeutic frontiers.

Survey of ophthalmology

Midterm results after allogeneic simple limbal epithelial transplantation from deceased-donor eyes in patients with persistent corneal epithelial defects due to limbal stem cell deficiency.

Acta ophthalmologica

Limbal Stem Cell Deficiency After Treatment of Ocular Surface Squamous Neoplasia.

International journal of biological macromolecules

Biomolecule-based hydrogels as delivery systems for limbal stem cell transplantation: A review.

Application of eye organoids in the study of eye diseases.

Development and characterization of a preclinical mouse model of alkali-induced limbal stem cell deficiency.

Journal of translational medicine

Targeting limbal epithelial stem cells: master conductors of corneal epithelial regeneration from the bench to multilevel theranostics.

Femtosecond Laser-Assisted Autologous Glueless Simple Limbal Epithelial Transplantation in Unilateral Limbal Stem Cell Deficiency: 12-Month Outcome of the First Clinical Cases.

Comparison of Automated and Manual Measurement of Corneal Epithelial Thickness in Eyes With Limbal Stem Cell Deficiency.

Corneal stromal changes following simple limbal epithelial transplantation on Scheimpflug densitometry: Early results.

Duloxetine enhances PAX6 expression and suppresses innate immune responses in murine LPS-induced corneal inflammation.

Potential applications of mesenchymal stem cells in ocular surface immune-mediated disorders.

Survey of ophthalmology

Limbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiency.

Sustained descemetocele management with Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment.

Frontiers in ophthalmology

Prevalence of limbal stem cell deficiency at an academic referral center over a two-year period.

Durvalumab-associated limbal stem cell deficiency and secondary corneal perforation.

Co-existence of Neurotrophic Keratopathy in Eyes With Limbal Stem Cell Deficiency.

Three-Dimensional Reconstruction of Subbasal Nerve Density in Eyes With Limbal Stem Cell Deficiency: A Pilot Study.

Ver todos os 444 no EuropePMC

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Organizações que acompanham esta doença — pra ter apoio e orientação

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