Células-tronco do limbo, também conhecidas como células-tronco epiteliais da córnea, são células-tronco unipotentes localizadas na camada epitelial basal do limbo corneano. Elas formam o limite entre a córnea e a esclera. As características das células-tronco do limbo incluem uma taxa de renovação lenta, alto potencial proliferativo, clonogenicidade, expressão de marcadores de células-tronco, bem como a capacidade de regenerar todo o epitélio corneano. A proliferação das células-tronco do limbo tem o papel de manter a córnea; por exemplo, substituindo as células que são perdidas através das lágrimas. Além disso, essas células também impedem que as células epiteliais conjuntivais migrem para a superfície da córnea.
Introdução
O que você precisa saber de cara
Visão geral
As lesões da córnea com deficiência associada a células-tronco da córnea (limbo) decorrentes de queimaduras oculares, também referidas na literatura médica internacional como deficiência de células-tronco limbares (Limbal stem cell deficiency, código MONDO:0025667 e CID-10 H18.7), são condições que afetam a estrutura da superfície ocular. A condição apresenta uma prevalência estimada de 1 a 5 por 10.000 indivíduos, com padrão de herança considerado não aplicável e início de manifestação clínica que pode ocorrer na infância, primeira infância, adolescência, idade adulta ou velhice.[1][2]
Sinais e sintomas
Os achados clínicos e fenótipos associados a essa condição incluem dor ocular, fotofobia, blefaroespasmo, anormalidade da lacrimação e epífora. Observam-se alterações oculares estruturais como opacificação generalizada da córnea, opacificação do epitélio corneano, neovascularização corneana, ceratite, cicatriz corneana e risco de perfuração corneana.[1][2]
Outras manifestações descritas compreendem hiperemia conjuntival, acuidade visual reduzida, reflexo corneano diminuído e córnea verticillata.[1][2]
Causas genéticas
Diagnóstico
Tratamento e manejo
Em relação ao Sistema Único de Saúde (SUS), a condição está classificada com o nível 'Sem cobertura SUS', inexistindo registros de procedimentos específicos, decisões da CONITEC ou medicamentos dispensados pelo SUS para esta condição nos dados catalogados. Existem 9 ensaios clínicos ativos registrados nas fontes analisadas.[1][4]
Tratamentos citados na literatura
Com base na mineração de literatura científica biomédica via PubTator3, foram identificadas associações bibliográficas de diversas substâncias e intervenções com o termo da condição, as quais refletem unicamente menções científicas e NÃO constituem recomendação médica ou indicação de uso: Cyclosporine (16 publicações), Tacrolimus (10 publicações), Mitomycin (7 publicações), Steroids (7 publicações), Mycophenolic Acid (6 publicações), Bevacizumab (4 publicações), Resveratrol (3 publicações), Polyglactin 910 (2 publicações), Amphotericin B (2 publicações) e Chitosan (2 publicações).[4]
Conteúdo informativo gerado e mantido automaticamente a partir de fontes oficiais (Orphanet, HPO, OMIM, SUS). Não substitui avaliação médica.
Esta condição é um dano grave na superfície do olho provocado por queimaduras térmicas ou químicas, que destrói as células-tronco da região do limbo responsáveis por renovar a córnea. A pessoa afetada costuma apresentar dor intensa, olhos avermelhados, lacrimejamento constante, sensibilidade extrema à luz e embaçamento ou perda importante da visão. Por se tratar de uma sequela traumática, o problema não é transmitido geneticamente de pais para filhos. A doença não possui Protocolo Clínico (PCDT) próprio no Ministério da Saúde, devendo o paciente buscar acompanhamento na rede de oftalmologia do SUS.
Células-tronco do limbo, também conhecidas como células-tronco epiteliais da córnea, são células-tronco unipotentes localizadas na camada epitelial basal do limbo corneano. Elas formam o limite entre a córnea e a esclera. As características das células-tronco do limbo incluem uma taxa de renovação lenta, alto potencial proliferativo, clonogenicidade, expressão de marcadores de células-tronco, bem como a capacidade de regenerar todo o epitélio corneano. A proliferação das células-tronco do limbo tem o papel de manter a córnea; por exemplo, substituindo as células que são perdidas através das lágrimas. Além disso, essas células também impedem que as células epiteliais conjuntivais migrem para a superfície da córnea.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Entender a doença
Do básico ao detalhe, leia no seu ritmo
Preparando trilha educativa...
Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 6 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 15 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
Encontrou um erro ou informação desatualizada? Sugira uma correção →
Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Lesões da córnea, com deficiência associada a células-tronco da córnea (limbo), por queimaduras oculares
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
Com ensaio aberto em 6 países. O ponto verde marca onde há vaga agora.
🟢 Recrutando agora
6 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
36 ensaios clínicos encontrados, 9 ativos.
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 948
Endogenous Therapeutic Agents for Acute Corneal and Ocular Surface Injuries.
Acute corneal injuries vary greatly in morbidity, but can cause severe cases of vision loss. Among these injuries are mechanical corneal traumas and acute chemical burns. The current standard of care in the acute phase of management is aimed at reducing the offending agent, pain management, and infection prevention; however, corneal scarring and limbal stem cell deficiency may result even after the acute management of severe corneal injuries. In the most serious cases, surgical intervention, including cornea or stem cell transplantation, may be required to restore functional vision. As such, there is a great need for additional therapies in the acute phase of management that can help to reduce long-term, vision-reducing outcomes. Certain endogenous agents have emerged as a therapeutic class that may be used for the promotion of corneal wound healing with the goal of reducing the odds of requiring invasive surgery. In this review, we provide an overview of novel endogenous therapeutic agents for the treatment of acute corneal trauma and acute chemical burns. The endogenous therapeutic agents explored include amnion, exosomes, stem cells, platelet-rich plasma, peptides, growth factors, and umbilical cord serum. The results of these studies indicate encouraging potential for endogenous agents to facilitate corneal recovery and vision preservation. However, because many of these agents are in the early stages of development and clinical trials, further research is required to understand their efficacy in the clinical setting.
Repair of Corneal Epithelial Defects.
The corneal epithelium, a stratified squamous non-keratinized layer of 50-60 μm thickness, forms the outermost barrier of the cornea and provides both optical clarity and protection against trauma, infection, and fluid imbalance. It plays a vital role in protecting the eye and maintaining visual clarity. A range of conditions, including trauma, metabolic disorders, microbial infection, and limbal stem cell deficiency, can lead to chronic corneal epithelial defects and subsequent visual impairment. Epithelial renewal is a continuous process, primarily sustained by stem cells located at the limbus. These stem cells give rise to transient amplifying cells, which migrate centripetally and superficially to maintain epithelial integrity. Wound healing follows a highly regulated sequence, superficial cells slide to cover the defect, basal cells proliferate, and corneal nerves realign to support epithelial stratification. This process is orchestrated by cytoskeletal remodeling, integrin-matrix interactions, and growth factor signaling. The epithelium relies on glucose from the corneal stroma, primarily metabolized through glycolysis, while mitochondrial oxidative phosphorylation generates the ATP required for repair. Thus, epithelial regeneration is closely tied to cellular energy availability. Enhancing this process involves supporting mitochondrial function, metabolic signaling pathways, and stem cell activity. Emerging strategies in regenerative ophthalmology include NAD+ replenishment, activation of AMP-activated protein kinase (AMPK), application of growth factors, targeted nanotherapies, and photobiomodulation. This chapter explores these cutting-edge approaches aimed at promoting energy-driven regeneration of the corneal surface.
In situ spatial transcriptomics reveals novel markers of the limbal stem cell niche and ocular surface epithelia.
The mammalian cornea is endowed with stem cells (SCs) that have lifelong regenerative activity. The niche for these cells is the limbus, and damage to it or its SCs results in limbal stem cell deficiency (LSCD). Despite the numerous studies that employ single-cell RNA sequencing, the identity of these cells remains an enigma principally because their spatial positioning is lost upon dissociation. These adversities were avoided via on-tissue spatial transcriptomics where Krt16 and Nkiras1 were differentially expressed. Krt16 was dynamically expressed in the developing limbus, correlated with slow-cycling label-retaining limbal epithelial SCs and was induced during corneal injury, observations consistent with marking functional SCs. Additionally, we established Nkiras1 as a novel maker of limbal neutrophils. Because current gold-standard treatments for LSCD include SC transplantation, our data will inform future studies in delivering a more reliable standard therapy that incorporates an identifiable SC population to improve clinical outcomes.
PAX6 Deficiency Compromises the Ability of Limbal Epithelial Stem Cells to Properly Differentiate Into Mature Corneal Epithelial Cells.
Aniridia, driven by PAX6 mutations, causes aniridia-associated keratopathy (AAK), a progressive condition linked to limbal stem cell deficiency. A major hurdle to developing targeted therapies for AAK is the incomplete understanding of the molecular abnormalities in affected corneas. To address this, we leveraged Pax6± (Pax6 het) mice, a model of AAK, and applied single-cell RNA sequencing (scRNA-seq) to profile the transcriptomic changes at a single-cell resolution. ScRNA-seq of corneal/limbal tissues of wild type (WT) and Pax6 het mice were conducted. Immunostaining was performed to examine the expression of specific markers for stem cells. ScRNA-seq identified a quiescent limbal epithelial stem cell (LESC)-like cell cluster and an early transient amplifying cell (eTAC)-like cluster. An increase in the cell numbers in these two clusters in the Pax6 het mouse corneas was observed. Immunostaining detected a marked increase in markers for these two clusters including Tmem176b, Apoe, and Krt15 in the corneal epithelium of Pax6 het mice, suggesting an increase of these LESC/eTA-like cells into the corneal epithelium. The Pax6 deficiency inhibited the expression of genes involved in cell proliferation in the eTAC-like cluster as well as the expression of genes related to corneal epithelial cell fate and differentiation compared with WT mice. Our single cell transcriptome of the limbus and cornea of Pax6 het mice indicates that AAK may be due to the increase of dysfunctional stem/eTACs with defects in committing to a corneal epithelial cell fate and differentiation.
Losartan Alleviates Chemical Burn-Induced Limbal Stem Cell Deficiency: Repurposing a Venerable Anti-Hypertension Drug.
Currently, treatment for limbal stem cell deficiency (LSCD) involves limbal stem cell transplantation using either autologous or allogeneic tissue to restore the corneal surface. However, limitations such as donor shortages, immune rejection, and variable outcomes highlight a crucial need for more effective and safer therapeutic options. We utilized a nitrogen mustard (NM)-induced corneal injury model to create LSCD, characterized by conjunctivalization. Mice exposed to NM were intraperitoneally injected with losartan. Single cell RNA sequencing (scRNA-seq) was conducted using a 10X Genomics platform. Previously, we demonstrated that corneal inflammation can be reversed by treatment with losartan, a widely used anti-hypertension drug with established long-term safety. Here, we demonstrate that systemic treatment with losartan markedly decreased corneal haze and inflammation during the acute and delayed phases of NM corneal injury. In the delayed phase, losartan treatment reduced NM-induced neovascularization in the cornea. Goblet cells detected within the corneal epithelium (conjunctivalization) during the delayed phase were significantly reduced following losartan treatment, indicating that losartan significantly resolves this classical hallmark of LSCD. The scRNA-seq showed that NM injury induced a dramatic increase in monocytes/macrophages in the cornea and that such an increase was attenuated by losartan treatment. Flow cytometry analysis confirmed that losartan attenuated corneal inflammation via reducing the monocytes/macrophages in the cornea. Our findings strongly support a new therapeutic use for losartan in blunting LSCD, which is a consequence associated with numerous corneal inflammatory conditions (e.g. diabetic keratopathy and tear gland insufficiency).
Publicações recentes
Melanocytes as key cells of the limbal stem cell niche: Roles in ocular surface homeostasis, disease, and regenerative therapy.
Descemet Membrane Anterior Keratoplasty With BrightMEM Corneal Allograft: An Innovative Technique for Treatment of Nonhealing Diseases of the Ocular Surface.
Treatment of vernal keratoconjunctivitis simulating total limbal stem cell deficiency: a case report.
Transparent GelMA biomaterials: Advanced solutions for ocular tissue engineering and regenerative ophthalmology.
Anterior Segment Optical Coherence Tomography with Angiography for the Cornea and Ocular Surface.
📚 EuropePMC444 artigos no totalmostrando 194
Endogenous Therapeutic Agents for Acute Corneal and Ocular Surface Injuries.
Translational vision science & technologyImplementing stem-cell therapies for limbal stem cell deficiency.
Regenerative medicineAltered Ocular Surface Temperature in Congenital Aniridia with PAX6 Pathogenic Variants: Impact of Age, Salzmann Nodules and Ocular Surgery.
Life (Basel, Switzerland)Emerging zoonotic ocular sporotrichosis in southeast Asia: a case series from Thailand and systematic review of regional reports.
Journal of ophthalmic inflammation and infectionRepair of Corneal Epithelial Defects.
Progress in molecular and subcellular biologyAutomated Image Registration Method for In Vivo Confocal Microscopy of the Corneal Sub-basal Nerve Plexus.
AMIA ... Annual Symposium proceedings. AMIA SymposiumExploring the impact of human pluripotent stem cell heterogeneity on corneal limbal stem cell differentiation outcomes.
Scientific reportsAustralasian consensus recommendations on stem cell therapies for managing ocular surface diseases.
The ocular surfaceCultivated Oral Mucosal Epithelial Transplantation for Limbal Stem Cell Deficiency: A Scoping Review of Indications, Platforms, Outcomes and Safety.
Journal of clinical medicineIn situ spatial transcriptomics reveals novel markers of the limbal stem cell niche and ocular surface epithelia.
Stem cell reportsEfficacy of Cultivated Oral Mucosal Epithelial Transplantation for Limbal Stem Cell Deficiency in Stevens-Johnson Syndrome Versus Other Etiologies.
CorneaAssociation Between Neurotrophic Keratitis and Limbal Stem Cell Deficiency.
American journal of ophthalmologyPAX6 Deficiency Compromises the Ability of Limbal Epithelial Stem Cells to Properly Differentiate Into Mature Corneal Epithelial Cells.
Investigative ophthalmology & visual scienceThe Role of the Boston Keratoprosthesis in Severe Ocular Surface Disease and Autoimmune Diseases.
Seminars in ophthalmologyCorneal macrophages and limbal stem cells: emerging roles in ocular surface regeneration.
Annals of medicineLosartan Alleviates Chemical Burn-Induced Limbal Stem Cell Deficiency: Repurposing a Venerable Anti-Hypertension Drug.
Investigative ophthalmology & visual scienceLetter to Editor: Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns.
The ocular surfaceLimbal Epithelial Stem Cells in Review: Immune and Lymphangiogenic Privilege and Their Clinical Relevance.
CellsImpact of Smoking on the Efficacy of Human Autologous Oral Mucosal Epithelial Cell Sheet Transplantation for Treating Limbal Stem Cell Deficiency.
Stem cells internationalGeneration of a Bioengineered Substitute of the Human Sclero-Corneal Limbus Using a Novel Decellularization Method.
PharmaceuticsOutcome of Allogeneic Penetrating Limbo-Keratoplasty: A Single-Center Retrospective Cohort Study.
Journal of clinical medicineDevelopment of a microscopy-based diagnostic test for alkali injury-induced limbal stem cell deficiency through Autofluorescence Multispectral Imaging.
Experimental eye researchClinical Outcomes of Different Surgical Techniques in Limbal Stem Cell Deficiency.
Turkish journal of ophthalmologyMultimodal objective assessment of a porcine limbal stem cell deficiency model for corneal therapy research.
Scientific reportsLimbal Vascular Regrowth After Ocular Surface Chemical Injuries: Imaging by Anterior Segment Optical Coherence Tomography Angiography.
Eye & contact lensChronic Ocular Complications in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis: Clinical Features and Surgical Management in a Brazilian Tertiary Center.
CorneaDescemet Membrane Versus Amniotic Membrane for Limbal Stem Cell Therapy.
CorneaLong-Term Outcomes of Boston Type I Keratoprosthesis After Minor Salivary Gland Transplantation and Labial Mucous Membrane Grafting as an Alternative Treatment for Stevens-Johnson Syndrome.
CorneaAdvancements in Cellular Therapeutics in Corneal Diseases.
CellsCurrent Landscape and Future Prospects of Corneal Regenerative Medicine.
Ophthalmology and therapyLimbal Epithelial Cells Detected in Stage III Limbal Stem Cell Deficiency by Multimodal Anterior Segment Imaging.
American journal of ophthalmologyMechanistic insights into conjunctivalization in limbal stem cell deficiency using a lineage tracing approach.
The ocular surfaceCorneal Epithelial Tissue Engineering Strategy Based on Cell Viability Optimization: A Review and Prospects.
Bioengineering (Basel, Switzerland)Ocular involvement in Stevens-Johnson syndrome and toxic epidermal necrolysis: A review of current management and changing trends.
Indian journal of ophthalmologyThe efficacy of bone marrow-derived mesenchymal stem cells in restoring limbal stem cell deficiency in rat model.
Scientific reportsOutcome of Cenegermin in the Treatment of Neurotrophic Keratopathy.
CorneaDemographics, Prevalence, and Characteristics of Limbal Stem Cell Deficiency in Southern California.
CorneaDouble Layered 9-mm Dehydrated Amniotic Membrane Disc in Ocular Surface Disorders: A Case Series.
Eye & contact lensBone marrow-versus adipose tissue-derived mesenchymal stem cells for corneal failure in an experimental model of limbal stem cell deficiency.
Experimental eye research[Short-term outcomes of corneal epithelial reconstruction in patients with bilateral limbal stem cell deficiency using paralimbal oral mucosal epithelial transplantation].
Vestnik oftalmologiiApplications of Modern Cell Therapies: The Latest Data in Ophthalmology.
Life (Basel, Switzerland)Topical 5-fluorouracil 1% versus surgical removal as a primary treatment modality for ocular surface squamous neoplasia: a comparison of recurrences and side effects.
BMC ophthalmologyClinical anatomy: cornea and ocular surface.
Medical hypothesis, discovery & innovation ophthalmology journalLimbal stem cell sheet bandage for short-term treatment of corneal regeneration.
BMC ophthalmologyTherapeutic effects of adipose mesenchymal stem cell-derived exosomes on limbal stem cells deficiency in cats.
Veterinary research communicationsTopical Chemotherapy for Ocular Surface Squamous Neoplasia: A Review of Adverse Effects and Their Clinical Management.
Oncology researchRepairing Effect and Mechanism of the 4-Dimensionally Printed Limbal Stem Cell Strategy on Corneal Alkali Burns in Large Animals.
Biomaterials researchClinical Outcomes of Keratolimbal Allograft Transplantation With Oral Mucosal Transplantation for Limbal Stem Cell Deficiency With Symblepharon.
Stem cells internationalClinical outcomes of simple limbal epithelial transplantation for limbal stem cell deficiency in a Mexican population.
Indian journal of ophthalmologyDevelopment of a high-resolution three-dimensional optical coherence tomography for characterization of epithelial cell products for corneal cell therapy.
Taiwan journal of ophthalmologyLimbal stem cell deficiency secondary to vitrectomy in the context of an autoimmune polyendocrine syndrome type.
American journal of ophthalmology case reportsThe role of limbal stem cells on neurotrophic cornea.
Clinical & experimental optometryOutcomes of Collagen Crosslinking in Patients with Keratoconus and Co-Existent Limbal Stem Cell Deficiency.
Clinical ophthalmology (Auckland, N.Z.)[Autologous oral mucosal epithelial transplantation in the treatment of bilateral limbal stem cell deficiency].
Vestnik oftalmologiiTopical erythropoietin in the management of scleral necrosis: a narrative review.
Therapeutic advances in ophthalmologyIVCM image analysis for limbal stem cell deficiency: quantitative diagnostics of the corneal epithelium post-transplant recovery.
The ocular surfaceSurgical Management of Corneal Sequelae of Vernal Keratoconjunctivitis.
Seminars in ophthalmologyOcular Complications in stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Comprehensive Review.
Seminars in ophthalmologyChallenges in Managing the Ocular Complications of Stevens-Johnson Syndrome in Patients with Co-Existent Auto-Immune Disease.
Seminars in ophthalmologyChronic Ocular Sequelae of Stevens-Johnson Syndrome: Recent Advances in Understanding of Patho-Physiology and Management.
Seminars in ophthalmologyFinger's continuous bipedicle conjunctival flap.
American journal of ophthalmology case reportsCorneal surface reconstruction for the chemical injured eye by transplanting autologous cultivated limbal epithelial sheet "Nepic®".
Fujita medical journalModified Simple Limbal Epithelial Transplant for the Treatment of Symblepharon in Cats: A Pilot Study.
Veterinary ophthalmologyDifferent Expression of Vascularization and Inflammatory Regulators in Cells Derived from Oral Mucosa and Limbus.
Bioengineering (Basel, Switzerland)Prospective consecutive case series of patients with neurotrophic keratopathy associated with unilateral total limbal stem cell deficiency caused by severe ocular surface burns.
The ocular surfaceMicrobial Keratitis in Ocular Surface Disease.
Seminars in ophthalmologyDecade-Long Follow-Up of Autologous Simple Limbal Epithelial Transplantation in Pediatric Patients With Unilateral Chemical Injury: A Case Series.
CorneaNovel Surgical Approach for Limbal Dermoid Excision: Utilizing Bowman's Membrane Lenticule and Autologous Limbal Stem Cell Transplantation for Enhanced Epithelial Healing and Visual Outcomes.
Vision (Basel, Switzerland)Corneal irregularity of the anterior and posterior surface in patients with limbal stem cell deficiency evaluated with anterior-segment optical coherence tomography.
Japanese journal of ophthalmologyAssessment of the official national insurance coverage of regenerative medical products for ophthalmic diseases in Japan following regulatory approval.
Regenerative therapyCorneal melting following intrastromal injection of bevacizumab for corneal neovascularization.
Oman journal of ophthalmologyClinical evidence and critical review of mesenchymal stromal cells for corneal and ocular surface diseases.
Stem cells (Dayton, Ohio)Autologous Glueless Simple Limbal Epithelial Transplantation for Unilateral Stem Cell Deficiency Using Femtosecond Laser-Assisted Limbal Stem Cell Harvesting: The Report of the First 3 Clinical Cases.
CorneaAnnular Conjunctival Autograft (ACAU): Modified Technique for Ocular Surface Reconstruction in Unilateral Chemical Burn.
Mymensingh medical journal : MMJDNA damage in oral mucosal epithelial cells cultured in complex and xenobiotic-free media: a comparison study.
MutagenesisSymblepharon: A Review of Etiology, Clinical Features, and Management Strategies.
Seminars in ophthalmologyInsights Into the Pathophysiology of Superior Limbic Keratoconjunctivitis in Chronic Ocular Graft-Versus-Host Disease.
Eye & contact lensInternational corneal and ocular surface disease dataset for electronic health records.
The British journal of ophthalmologyStevens-Johnson Syndrome as a Risk Factor for Ocular Surface Squamous Neoplasia in a Pediatric Patient.
CureusVernal Keratoconjunctivitis: Impact on Children.
Eye & contact lensOutcomes in Acute Ocular Surface Chemical Injury-Role of pH Measurement on Presentation: A Retrospective Cohort Study.
Ophthalmology and therapyTopical delivery of cultivated limbal stem cells via porous photocurable hydrogel: A noninvasive, convenient, and efficient stem cells delivery strategy for limbal stem cell deficiency.
Journal of controlled release : official journal of the Controlled Release SocietyChirality Regulates Stem Cell Fate and Promotes Corneal Epithelial Regeneration via Manipulating Notch Pathway.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)Limbal stem cell deficiency: a dreaded complication of chickenpox in children.
Oxford medical case reportsTreatment Options for Alkali Burn-Induced Corneal Neovascularization: A Comparative Analysis of Two Tyrosine Kinase Inhibitors.
CorneaSafety of subconjunctival injection of mesenchymal stromal cells in persistent corneal epithelial disease - A phase 1b clinical trial.
The ocular surfaceOptimizing Keratolimbal Allograft Outcomes: Optical Coherence Tomography Analysis of Donor Graft Phenotypes in Limbal Stem Cell Deficiency.
CorneaAmniotic Membrane Transplantation for Wound Healing, Tissue Regeneration and Immune Modulation.
Stem cell reviews and reportsIatrogenic Ocular Surface Complications After Surgery for Ocular and Adnexal Tumors.
CancersTemporal Differences in the Expression of p63α and Proliferation of Limbal Epithelial Stem Cells From Donor Corneas.
Cornea[Nonpenetrating surgical approaches to promote corneal homeostasis].
Die OphthalmologieCultivated Autologous Limbal Epithelial Cell Transplantation: A Review of Clinical Trials and Applications.
CorneaMultiple Stem/Progenitor Cells Isolated from the Limbus.
Current stem cell research & therapyManagement of Intraocular Pressure Elevation After Commercially Available Cultivated Oral Mucosal Epithelial Cell Transplantation for Limbal Stem Cell Deficiency.
CureusA Case-Based Approach to the Management of Corneal Melts and Perforations in Ocular Surface Disorders.
CureusCan Stem Cell Therapy Revolutionize Ocular Disease Treatment? A Critical Review of Preclinical and Clinical Advances.
Stem cell reviews and reportsEmerging Treatments for Persistent Corneal Epithelial Defects.
Vision (Basel, Switzerland)Limbal explant cultures on amniotic membrane: The effects of passaging the explants on cell phenotype.
Experimental eye researchOcular surface squamous neoplasia masquerades: Clinical profile and outcome.
Indian journal of ophthalmologyVisual Outcomes of Limbal Stem Cell Transplantation in the IRIS® Registry.
OphthalmologyPAX3 expression patterns in ocular surface melanocytes.
Scientific reportsDemographics of Limbal Stem Cell Deficiency: A Literature Review.
Eye & contact lensImmunological and histopathological changes in alkali burn-induced ocular surface pannus: Implication on success vs. failure of SLET.
Experimental eye researchLimbal Stem Cell Deficiency Induced by Prolonged Use of Topical 0.03% Tacrolimus Ointment in a Patient With Atopic Keratoconjunctivitis.
Eye & contact lensDecellularized human amniotic member hydrogel promotes limbal stem cells proliferation.
Colloids and surfaces. B, BiointerfacesAutologous glueless simple oral mucosal transplantation for the repair of limbal stem cell deficiency ocular surface in a rabbit model.
Scientific reportsCentral Cornea Changes on Anterior Segment OCT and In Vivo Confocal Microscopy After Autologous Limbal Epithelial Cell Transplantation.
CorneaAdvancing Bilateral Limbal Deficiency Surgery: A Comprehensive Review of Innovations with Mucosal Cells.
BiomedicinesRisk Factors for Development of Limbal Stem Cell Deficiency After Acute Ocular Burns.
Current eye researchUnpacking VKC: How gender and age shape the clinical picture.
Indian journal of ophthalmologyPreferred practice guidelines and narrative review on infectious keratitis in ocular surface diseases.
Indian journal of ophthalmologyLimbal stem cell deficiency approaches and limbal niche restoration.
Indian journal of ophthalmologyAdvances in Regenerative Medicine, Cell Therapy, and 3D Bioprinting for Corneal, Oculoplastic, and Orbital Surgery.
Advances in experimental medicine and biologyA novel therapy to ameliorate nitrogen mustard-induced limbal stem cell deficiency using lipoprotein-like nanoparticles.
NPJ Regenerative medicineAdjuvant Brachytherapy Using Iodine-125 Plaques for Conjunctival Melanoma with Scleral Invasion.
Seminars in ophthalmologyTimeframe to Keratoplasty After Ocular Surface Stem Cell Transplantation.
CorneaMineralocorticoid receptor antagonism improves corneal integrity in a rat model of limbal stem cell deficiency.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapieInterferon alpha-2b versus 5-fluorouracil as primary treatment modalities for ocular surface squamous neoplasia: a study of 116 eyes.
International ophthalmologySludging: A Postoperative Clinical Finding After Ocular Surface Stem Cell Transplantation.
CorneaCultivated autologous limbal epithelial cell (CALEC) transplantation for limbal tem cell deficiency: a phase I/II clinical trial of the first xenobiotic-free, serum-free, antibiotic-free manufacturing protocol developed in the US.
Nature communicationsAdjunct botulinum toxin for cicatricial pemphigoid.
Orbit (Amsterdam, Netherlands)Clinical efficacy and safety of proton radiotherapy for ocular conjunctival malignancies: a systematic review and meta-analysis.
Frontiers in public healthCultivation and characterization of oral mucosal epithelial cells on fibrin gel in a xenobiotic-free medium for the treatment of limbal stem cell deficiency.
Experimental eye researchBibliometric and Visual Analysis of the Status of Scleral Lens Research Based on the Web of Science Database and Scopus Database (2014-2024).
Clinical optometryDelayed Periocular and Anterior Segment Complications Following Locally Administered Chemotherapy for Vitreous Seeding in Retinoblastoma.
Seminars in ophthalmologyStiffness Regulates the Morphology and Stemness of Limbal Niche Cells Through Unique nYAP/cYAP Translocation.
Investigative ophthalmology & visual scienceThe watchmaker's eye: Exposure keratopathy with secondary limbal stem cell deficiency due to the use of a loupe.
Journal francais d'ophtalmologieUnveiling the Molecular Mechanisms Underlying the Success of Simple Limbal Epithelial Transplantation (SLET).
CellsIn vivo confocal microscopy in ophthalmology: research trends from a bibliometric analysis.
Clinical & experimental optometryFive- to Twelve-Year Outcomes of Autologous Simple Limbal Epithelial Transplantation: Long-Term Corneal Epithelial Imaging and Phenotypic Analysis.
American journal of ophthalmologyDual lamellar keratoplasty combined with phacoemulsification and intraocular Lens implantation in a case of severe chemical burn.
European journal of ophthalmologyDexamethasone mitigates sulfur mustard-induced stem cell deficiency in vivo in rabbit limbal tissue by reducing inflammation and oxidative stress.
Archives of toxicologyUse of an Eyelid Pressure Patch Concomitantly with a Decellularized Dehydrated Amniotic Membrane for Ocular Surface Disease Management.
Ophthalmology and therapyTopical application of amniotic membrane extract at a clinically correlated dose is effective in limiting complications in an experimental ocular alkaline burn model.
Experimental eye researchDiagnostic approach to limbal stem cell deficiency.
Frontiers in ophthalmologyThermal ocular burns and evaluation of associated limbal stem cell deficiency in the light of global consensus.
International ophthalmologyInsights from 1096 clinical cases: pioneering a universal grading system for vernal keratoconjunctivitis management.
The British journal of ophthalmologyBiomedical Application of MSCs in Corneal Regeneration and Repair.
International journal of molecular sciencesClassification and treatment approach of chemical burn associated Limbal stem cell deficiency: based on novel global consensus.
International ophthalmologyFemtosecond laser-assisted large-diameter lamellar corneal-limbal keratoplasty in ocular chemical burns.
American journal of ophthalmology case reportsSeroma under the amniotic membrane following simple limbal epithelial transplantation.
BMJ case reportsRho kinase inhibitor Y-27632 and dual media culture approach promote the construction and transplantation of rabbit limbal epithelial cell sheets via cell spheroid culture and auto-bioprinting.
Acta biomaterialia3D printed biomimetic bilayer limbal implants for regeneration of the corneal structure in limbal stem cell deficiency.
Acta biomaterialiaOral Cyclosporine in Vernal Keratoconjunctivitis: Indications, Outcomes, and Effect on Corticosteroid Use.
CorneaEccentric Superficial Anterior Lamellar Keratoplasty for Bilateral Limbal Stem Cell Deficiency.
CorneaDevelopment of Biomimetic Substrates for Limbal Epithelial Stem Cells Using Collagen-Based Films, Hyaluronic Acid, Immortalized Cells, and Macromolecular Crowding.
Life (Basel, Switzerland)RSPO3 Promotes Proliferation and Self-Renewal of Limbal Epithelial Stem Cells Through a WNT/β-Catenin-Independent Signaling Pathway.
Investigative ophthalmology & visual scienceAllogenic Cultured Limbal Epithelial Transplantation and Cultivated Oral Mucosal Epithelial Transplantation in Limbal Stem Cells Deficiency: A Comparative Study.
Ophthalmology and therapyAcquired Ankyloblepharon Correction Using Ocular Surface and Tarsal Mucous Membrane Grafting in Cicatrizing Ocular Surface Diseases.
Ophthalmic plastic and reconstructive surgeryAdvances in the Diagnosis and Management of Limbal Stem Cell Deficiency.
CorneaEffect of Cryoprotectants on Long-Term Storage of Oral Mucosal Epithelial Cells: Implications for Stem Cell Preservation and Proliferation Status.
Folia biologicaAutologous simple limbal stem cell transplantation with conjunctival autograft in chronic unilateral total LSCD with severe symblepharon due to severe alkali burn.
BMJ case reportsEstablishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures.
Journal of visualized experiments : JoVECurrent and emerging strategies for the manufacture, implantation, and clinical management of corneal tissue allografts.
Clinical & experimental optometryIntraocular use of methotrexate (MTX) for the treatment of proliferative vitreoretinopathy (PVR) in congenital aniridia (CI) and a possible link to aniridia fibrosis syndrome (AFS) treatment.
American journal of ophthalmology case reportsTNF-α Suppression Attenuates Limbal Stem Cell Damage in Ocular Injury.
CorneaA human-like model of aniridia-associated keratopathy for mechanistic and therapeutic studies.
JCI insightClinical and surgical outcomes of tectonic corneal patch grafts : insights from a tertiary referral hospital.
BMC ophthalmologyMultimodal Imaging Findings in Limbal Stem Cell Deficiency due to Hydroxyurea.
OphthalmologyBiology and medicine on ocular surface restoration: Advancements and limits of limbal stem cell deficiency treatments.
The ocular surfaceConcurrent Limbal Stem Cell Deficiency and Mild Neurotrophic Keratopathy in Graft-Vs-Host Disease.
CorneaProliferation and differentiation of Wharton's jelly-derived mesenchymal stem cells on prgf-treated hydrogel scaffold.
Regenerative medicineInduced pluripotent stem-cell-derived corneal epithelium for transplant surgery: a single-arm, open-label, first-in-human interventional study in Japan.
Lancet (London, England)Enhancing Ex Vivo Limbal Epithelial Cell Expansion on Amniotic Membrane: A Comparative Study of Monolayer (2D) Versus Sandwich (3D) Culture Configurations.
CorneaProgress in Transdifferentiation of Autologous Alternative Cell Sources into Corneal Epithelial Cells.
Stem cell reviews and reportsDonor Tissue Preservation Time Impact on Keratolimbal Allograft Outcomes.
CorneaPediatric limbal stem cell deficiency: An overview of a rarely studied pathology.
European journal of ophthalmologyA limbal stem cell deficiency murine model with residual limbal stem cells.
bioRxiv : the preprint server for biologyEvaluation of Medically Reversible Limbal Stem Cell Deficiency.
Turkish journal of ophthalmologyAnterior Segment Optical Coherence Tomography Angiography: A Review of Applications for the Cornea and Ocular Surface.
Medicina (Kaunas, Lithuania)Molecular and Cellular Mechanisms of the Therapeutic Effect of Mesenchymal Stem Cells and Extracellular Vesicles in Corneal Regeneration.
International journal of molecular sciencesSimple limbal epithelial transplantation versus cultivated limbal epithelial transplantation in ocular burns.
The ocular surface"En bloc" combined 270-degree keratolimbal allograft with central lamellar keratoplasty for severe limbal stem cell deficiency secondary to mustard gas exposure.
The ocular surfaceSurgical Technique for Oral Mucosa Harvesting in Autologous Cultivated Oral Mucosal Epithelial Cell Transplantation for Ocular Surface Disorders.
CureusBio-printing method as a novel approach to obtain a fibrin scaffold settled by limbal epithelial cells for corneal regeneration.
Scientific reportsVisual outcomes of primary keratoprosthesis implantation in transplant-naïve eyes.
PloS oneChallenging corneal diseases and microRNA expression: Focus on rare diseases and new therapeutic frontiers.
Survey of ophthalmologyMidterm results after allogeneic simple limbal epithelial transplantation from deceased-donor eyes in patients with persistent corneal epithelial defects due to limbal stem cell deficiency.
Acta ophthalmologicaLimbal Stem Cell Deficiency After Treatment of Ocular Surface Squamous Neoplasia.
CorneaBiomolecule-based hydrogels as delivery systems for limbal stem cell transplantation: A review.
International journal of biological macromoleculesApplication of eye organoids in the study of eye diseases.
Experimental eye researchDevelopment and characterization of a preclinical mouse model of alkali-induced limbal stem cell deficiency.
The ocular surfaceTargeting limbal epithelial stem cells: master conductors of corneal epithelial regeneration from the bench to multilevel theranostics.
Journal of translational medicineFemtosecond Laser-Assisted Autologous Glueless Simple Limbal Epithelial Transplantation in Unilateral Limbal Stem Cell Deficiency: 12-Month Outcome of the First Clinical Cases.
CorneaComparison of Automated and Manual Measurement of Corneal Epithelial Thickness in Eyes With Limbal Stem Cell Deficiency.
CorneaCorneal stromal changes following simple limbal epithelial transplantation on Scheimpflug densitometry: Early results.
Indian journal of ophthalmologyDuloxetine enhances PAX6 expression and suppresses innate immune responses in murine LPS-induced corneal inflammation.
The ocular surfacePotential applications of mesenchymal stem cells in ocular surface immune-mediated disorders.
Survey of ophthalmologyLimbal graft transplantation: a rare implementation in pediatric limbal stem cell deficiency.
International ophthalmologySustained descemetocele management with Prosthetic Replacement of the Ocular Surface Ecosystem (PROSE) treatment.
American journal of ophthalmology case reportsPrevalence of limbal stem cell deficiency at an academic referral center over a two-year period.
Frontiers in ophthalmologyDurvalumab-associated limbal stem cell deficiency and secondary corneal perforation.
American journal of ophthalmology case reportsCo-existence of Neurotrophic Keratopathy in Eyes With Limbal Stem Cell Deficiency.
American journal of ophthalmologyThree-Dimensional Reconstruction of Subbasal Nerve Density in Eyes With Limbal Stem Cell Deficiency: A Pilot Study.
CorneaAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
Ainda não temos associações cadastradas para Lesões da córnea, com deficiência associada a células-tronco da córnea (limbo), por queimaduras oculares.
É de uma associação que acompanha esta doença? Fale com a gente →
Doença com base genética
Um médico geneticista pode ajudar no diagnóstico de Lesões da córnea, com deficiência associada a células-tronco da córnea (limbo), por queimaduras oculares e no aconselhamento genético da família.
Doenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Perguntas frequentes
O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu
Ela é causada por queimaduras oculares físicas ou químicas que danificam o limbo corneano. Esse evento destrói as células-tronco que mantêm a transparência da córnea.
Referências
Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete
5 fontes citadas no texto · 10 publicações do grafo RarasNet (PubMed) · 4 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Citar este verbete
Raras. (2026). Lesões da córnea, com deficiência associada a células-tronco da córnea (limbo), por queimaduras oculares. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/lesoes-da-cornea-com-deficiencia-associada-a-celulas-tronco-da-cornea-limbo-por-queimaduras-oculares
Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
Lesões da córnea, com deficiência associada a células-tronco da córnea (limbo), por queimaduras oculares
📋 Origem dos dados
Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.
- Doença rara (ontologia)
- fonte: Orphanet
- Identificador unificado
- fonte: MONDO
- Codificação WHO/SUS
- fonte: WHO ICD-10 / DATASUS
- CID-11 (futuro)
- fonte: WHO ICD-11
- NIH/GARD
- fonte: GARD (NIH)
- Indexação biomédica
- fonte: MeSH (NLM)
- Dado público estruturado
- fonte: Wikidata
- Ensaios clínicos
- fonte: ClinicalTrials.gov
