[THOUGHT] The user wants a translation of a medical description into accessible Brazilian Portuguese. I need to maintain accuracy but use simple terms. I must return ONLY the translated text, no prefácio. Original text: "A rare, immune-mediated disorder characterized by cerebellar degeneration due to the presence of an often undetected malignancy (usually carcinoma or lymphoma) in an anatomic site other than the cerebellum. Signs and symptoms include progressive ataxia, dysarthria, and nystagmus." Let's break it down and simplify each part: 1. **"A rare, immune-mediated disorder"**: * "rare": raro * "immune-mediated disorder": uma doença causada pelo sistema de defesa do corpo (sistema imunológico) agindo de forma errada contra ele mesmo. "Doença autoimune" é uma boa simplificação, mas "mediado por autoimunidade" é mais literal. Let's try "uma doença rara em que o próprio sistema de defesa do corpo ataca o organismo". Or "uma doença rara causada por uma resposta errada do sistema imunológico". "Doença autoimune" might be too strong if it's "immune-mediated" and not strictly "autoimmune". Let's go with "uma doença rara em que o próprio sistema de defesa do corpo (o sistema imunológico) ataca as células". Or more simply "uma doença rara causada por uma ação errada do sistema imunológico (o sistema de defesa do corpo)". Let's try "uma doença rara em que o próprio sistema de defesa do corpo (o sistema imunológico) reage de forma errada". 2. **"characterized by cerebellar degeneration"**: * "characterized by": caracterizada por * "cerebellar degeneration": degeneração do cerebelo. Cerebelo é uma parte do cérebro. Degeneração significa que ele está estragando ou perdendo função. So, "caracterizada pela degeneração (ou seja, o estrago) do cerebelo, que é uma parte do cérebro". Or simpler: "que causa um estrago no cerebelo (uma parte do cérebro)". 3. **"due to the presence of an often undetected malignancy (usually carcinoma or lymphoma) in an anatomic site other than the cerebellum."**: * "due to the presence of": por causa da presença de * "an often undetected malignancy": um câncer (tumor maligno) que muitas vezes não é descoberto. "Malignancy" is "tumor maligno" or "câncer". "Often undetected" means "muitas vezes não detectado" or "que frequentemente passa despercebido". * "(usually carcinoma or lymphoma)": (geralmente um tipo de câncer chamado carcinoma ou linfoma). * "in an anatomic site other than the cerebellum": em outro lugar do corpo que não seja o cerebelo. "Anatomic site" -> "local do corpo". "Other than the cerebellum" -> "que não seja o cerebelo". * Combining this: "causado pela presença de um câncer (tumor maligno), muitas vezes não detectado, em outra parte do corpo que não o cerebelo (geralmente um tipo de câncer chamado carcinoma ou linfoma)". * Let's refine: "Essa degeneração acontece por causa de um câncer (tumor maligno) que costuma ser difícil de encontrar e está localizado em alguma outra parte do corpo, não no cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma)." 4. **"Signs and symptoms include progressive ataxia, dysarthria, and nystagmus."**: * "Signs and symptoms": Os sinais e sintomas. Or "Os sinais da doença incluem". * "progressive ataxia": ataxia progressiva. Ataxia é falta de coordenação. Progressiva significa que piora com o tempo. "dificuldade progressiva de coordenação dos movimentos". * "dysarthria": disartria. Disartria é dificuldade para articular as palavras. "dificuldade para falar, como se as palavras saíssem arrastadas". * "nystagmus": nistagmo. Nistagmo é movimento involuntário dos olhos. "movimentos involuntários dos olhos". * Combining this: "Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo)." Let's try to put it all together: "É uma doença rara em que o próprio sistema de defesa do corpo (o sistema imunológico) reage de forma errada. Ela é caracterizada pelo estrago do cerebelo (uma parte do cérebro). Esse estrago acontece por causa da presença de um câncer (tumor maligno) que muitas vezes não é detectado e está localizado em outra parte do corpo que não o cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma). Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo)." This sounds quite good and accessible. Let's review for precision and simplicity. "A rare, immune-mediated disorder" -> "É uma doença rara em que o próprio sistema de defesa do corpo (o sistema imunológico) reage de forma errada." - Good. "Ataca a si mesmo" might be even simpler than "reage de forma errada". "Doença autoimune" is the simplest and most common term for "immune-mediated" disorders where the immune system attacks the body's own tissues. I think it's acceptable here for accessibility. Let's try "É uma doença rara, considerada autoimune". "characterized by cerebellar degeneration" -> "caracterizada pelo estrago do cerebelo (uma parte do cérebro)." - "Estrago" is simple. "Degeneração" can be kept if explained or "deterioração". Let's stick with "estrago" for simplicity. "due to the presence of an often undetected malignancy (usually carcinoma or lymphoma) in an anatomic site other than the cerebellum." -> "que acontece devido à presença de um câncer (tumor maligno) que muitas vezes não é encontrado. Esse câncer está localizado em outra parte do corpo que não o cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma)." - This is good. "Costuma passar despercebido" instead of "muitas vezes não é encontrado" is also good. "Signs and symptoms include progressive ataxia, dysarthria, and nystagmus." -> "Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo)." - Excellent. Let's try again with the "autoimune" simplification: "É uma doença rara, considerada autoimune, que causa um estrago no cerebelo (uma parte do cérebro). Esse problema ocorre por causa de um câncer (tumor maligno) que muitas vezes passa despercebido e está localizado em outra parte do corpo, não no cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma). Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (chamada ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo)." This version is even more concise and direct. "Considerada autoimune" handles "immune-mediated" well for an accessible context. "causa um estrago no cerebelo" is very simple and clear for "cerebellar degeneration". "Esse problema ocorre por causa de um câncer (tumor maligno) que muitas vezes passa despercebido" is excellent for "due to the presence of an often undetected malignancy". "está localizado em outra parte do corpo, não no cerebelo" is clear for "in an anatomic site other than the cerebellum". The explanation for symptoms is good. Final check on "immune-mediated": while "autoimune" implies the immune system *directly* attacks healthy tissues, "immune-mediated" can be broader (e.g., inflammation *triggered* by immune responses, but not necessarily a direct attack on self). However, in the context of paraneoplastic syndromes (which this description sounds like), the immune response *is* directed against healthy tissues due to molecular mimicry with the tumor. So, "autoimune" or "com mecanismo autoimune" is generally accepted as an accessible explanation. "Considerada autoimune" makes it safe. Let's consider "carcinoma or lymphoma". Maybe just "tipos de câncer como carcinoma ou linfoma" is enough. One more pass: "É uma doença rara, de origem autoimune, que se caracteriza pela deterioração do cerebelo (uma parte do cérebro). Isso acontece por causa da presença de um câncer (tumor maligno) que, frequentemente, não é detectado e está localizado em alguma outra parte do corpo que não o cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma). Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo)." "Deterioração" is a bit more formal than "estrago" but still accessible. "De origem autoimune" is good. "frequentemente, não é detectado" is good. I think this version maintains precision while being simple. Let's stick to the last one. "Deterioração" is better than "estrago" for medical context, still simple enough. "De origem autoimune" is good. "frequentemente, não é detectado" is concise. The rest is clear.É uma doença rara, de origem autoimune, que se caracteriza pela deterioração do cerebelo (uma parte do cérebro). Isso acontece por causa da presença de um câncer (tumor maligno) que, frequentemente, não é detectado e está localizado em alguma outra parte do corpo que não o cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma). Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo).
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[THOUGHT] The user wants a translation of a medical description into accessible Brazilian Portuguese. I need to maintain accuracy but use simple terms. I must return ONLY the translated text, no prefácio. Original text: "A rare, immune-mediated disorder characterized by cerebellar degeneration due to the presence of an often undetected malignancy (usually carcinoma or lymphoma) in an anatomic site other than the cerebellum. Signs and symptoms include progressive ataxia, dysarthria, and nystagmus." Let's break it down and simplify each part: 1. **"A rare, immune-mediated disorder"**: * "rare": raro * "immune-mediated disorder": uma doença causada pelo sistema de defesa do corpo (sistema imunológico) agindo de forma errada contra ele mesmo. "Doença autoimune" é uma boa simplificação, mas "mediado por autoimunidade" é mais literal. Let's try "uma doença rara em que o próprio sistema de defesa do corpo ataca o organismo". Or "uma doença rara causada por uma resposta errada do sistema imunológico". "Doença autoimune" might be too strong if it's "immune-mediated" and not strictly "autoimmune". Let's go with "uma doença rara em que o próprio sistema de defesa do corpo (o sistema imunológico) ataca as células". Or more simply "uma doença rara causada por uma ação errada do sistema imunológico (o sistema de defesa do corpo)". Let's try "uma doença rara em que o próprio sistema de defesa do corpo (o sistema imunológico) reage de forma errada". 2. **"characterized by cerebellar degeneration"**: * "characterized by": caracterizada por * "cerebellar degeneration": degeneração do cerebelo. Cerebelo é uma parte do cérebro. Degeneração significa que ele está estragando ou perdendo função. So, "caracterizada pela degeneração (ou seja, o estrago) do cerebelo, que é uma parte do cérebro". Or simpler: "que causa um estrago no cerebelo (uma parte do cérebro)". 3. **"due to the presence of an often undetected malignancy (usually carcinoma or lymphoma) in an anatomic site other than the cerebellum."**: * "due to the presence of": por causa da presença de * "an often undetected malignancy": um câncer (tumor maligno) que muitas vezes não é descoberto. "Malignancy" is "tumor maligno" or "câncer". "Often undetected" means "muitas vezes não detectado" or "que frequentemente passa despercebido". * "(usually carcinoma or lymphoma)": (geralmente um tipo de câncer chamado carcinoma ou linfoma). * "in an anatomic site other than the cerebellum": em outro lugar do corpo que não seja o cerebelo. "Anatomic site" -> "local do corpo". "Other than the cerebellum" -> "que não seja o cerebelo". * Combining this: "causado pela presença de um câncer (tumor maligno), muitas vezes não detectado, em outra parte do corpo que não o cerebelo (geralmente um tipo de câncer chamado carcinoma ou linfoma)". * Let's refine: "Essa degeneração acontece por causa de um câncer (tumor maligno) que costuma ser difícil de encontrar e está localizado em alguma outra parte do corpo, não no cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma)." 4. **"Signs and symptoms include progressive ataxia, dysarthria, and nystagmus."**: * "Signs and symptoms": Os sinais e sintomas. Or "Os sinais da doença incluem". * "progressive ataxia": ataxia progressiva. Ataxia é falta de coordenação. Progressiva significa que piora com o tempo. "dificuldade progressiva de coordenação dos movimentos". * "dysarthria": disartria. Disartria é dificuldade para articular as palavras. "dificuldade para falar, como se as palavras saíssem arrastadas". * "nystagmus": nistagmo. Nistagmo é movimento involuntário dos olhos. "movimentos involuntários dos olhos". * Combining this: "Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo)." Let's try to put it all together: "É uma doença rara em que o próprio sistema de defesa do corpo (o sistema imunológico) reage de forma errada. Ela é caracterizada pelo estrago do cerebelo (uma parte do cérebro). Esse estrago acontece por causa da presença de um câncer (tumor maligno) que muitas vezes não é detectado e está localizado em outra parte do corpo que não o cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma). Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo)." This sounds quite good and accessible. Let's review for precision and simplicity. "A rare, immune-mediated disorder" -> "É uma doença rara em que o próprio sistema de defesa do corpo (o sistema imunológico) reage de forma errada." - Good. "Ataca a si mesmo" might be even simpler than "reage de forma errada". "Doença autoimune" is the simplest and most common term for "immune-mediated" disorders where the immune system attacks the body's own tissues. I think it's acceptable here for accessibility. Let's try "É uma doença rara, considerada autoimune". "characterized by cerebellar degeneration" -> "caracterizada pelo estrago do cerebelo (uma parte do cérebro)." - "Estrago" is simple. "Degeneração" can be kept if explained or "deterioração". Let's stick with "estrago" for simplicity. "due to the presence of an often undetected malignancy (usually carcinoma or lymphoma) in an anatomic site other than the cerebellum." -> "que acontece devido à presença de um câncer (tumor maligno) que muitas vezes não é encontrado. Esse câncer está localizado em outra parte do corpo que não o cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma)." - This is good. "Costuma passar despercebido" instead of "muitas vezes não é encontrado" is also good. "Signs and symptoms include progressive ataxia, dysarthria, and nystagmus." -> "Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo)." - Excellent. Let's try again with the "autoimune" simplification: "É uma doença rara, considerada autoimune, que causa um estrago no cerebelo (uma parte do cérebro). Esse problema ocorre por causa de um câncer (tumor maligno) que muitas vezes passa despercebido e está localizado em outra parte do corpo, não no cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma). Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (chamada ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo)." This version is even more concise and direct. "Considerada autoimune" handles "immune-mediated" well for an accessible context. "causa um estrago no cerebelo" is very simple and clear for "cerebellar degeneration". "Esse problema ocorre por causa de um câncer (tumor maligno) que muitas vezes passa despercebido" is excellent for "due to the presence of an often undetected malignancy". "está localizado em outra parte do corpo, não no cerebelo" is clear for "in an anatomic site other than the cerebellum". The explanation for symptoms is good. Final check on "immune-mediated": while "autoimune" implies the immune system *directly* attacks healthy tissues, "immune-mediated" can be broader (e.g., inflammation *triggered* by immune responses, but not necessarily a direct attack on self). However, in the context of paraneoplastic syndromes (which this description sounds like), the immune response *is* directed against healthy tissues due to molecular mimicry with the tumor. So, "autoimune" or "com mecanismo autoimune" is generally accepted as an accessible explanation. "Considerada autoimune" makes it safe. Let's consider "carcinoma or lymphoma". Maybe just "tipos de câncer como carcinoma ou linfoma" is enough. One more pass: "É uma doença rara, de origem autoimune, que se caracteriza pela deterioração do cerebelo (uma parte do cérebro). Isso acontece por causa da presença de um câncer (tumor maligno) que, frequentemente, não é detectado e está localizado em alguma outra parte do corpo que não o cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma). Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo)." "Deterioração" is a bit more formal than "estrago" but still accessible. "De origem autoimune" is good. "frequentemente, não é detectado" is good. I think this version maintains precision while being simple. Let's stick to the last one. "Deterioração" is better than "estrago" for medical context, still simple enough. "De origem autoimune" is good. "frequentemente, não é detectado" is concise. The rest is clear.É uma doença rara, de origem autoimune, que se caracteriza pela deterioração do cerebelo (uma parte do cérebro). Isso acontece por causa da presença de um câncer (tumor maligno) que, frequentemente, não é detectado e está localizado em alguma outra parte do corpo que não o cerebelo (geralmente é um tipo de câncer como carcinoma ou linfoma). Os sinais e sintomas incluem dificuldade progressiva de coordenação dos movimentos (ataxia), dificuldade para falar (disartria) e movimentos involuntários dos olhos (nistagmo).
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 15 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 24 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Degenerescência cerebelar paraneoplásica
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Although anti-Zic4 antibodies are associated with paraneoplastic cerebellar degeneration, predominantly in small-cell lung carcinoma, their role in postinfectious autoimmunity remains poorly understood. Here, we report a 53-year-old woman who developed progressive cerebellar degeneration following coronavirus disease 2019 (COVID-19), characterized by isolated anti-Zic4 antibody positivity in the absence of malignancy. Two months after developing mild respiratory symptoms, she developed dysarthria, imbalance, and gait ataxia. Neurological examination revealed gaze-evoked nystagmus, broad-based ataxia, and cerebellar dysmetria. Brain MRI demonstrated marked cerebellar atrophy, while cerebrospinal fluid analysis showed elevated protein, increased IgG index, and the presence of oligoclonal bands. Serological testing confirmed strong anti-Zic4 antibody positivity. Initial treatment with intravenous immunoglobulin and plasmapheresis achieved transient improvement and decreased antibody titers. However, 1 year later, recurrence of antibodies coincided with further cerebellar atrophy and posterior hypoperfusion on MRI and SPECT, despite maintenance immunotherapy with low-dose corticosteroids and periodic IVIG. Cognitive function was well preserved, highlighting the selective vulnerability of cerebellar circuits. This case illustrates an unusual phenotype of prolonged, isolated anti-Zic4 antibody-associated cerebellar degeneration triggered by SARS-CoV-2 infection, thus expanding the recognized clinical spectrum of Zic4-related disorders beyond paraneoplastic contexts. The underlying immunopathological mechanisms have yet to be elucidated. Notably, radiological progression was disproportionate to clinical stabilization, underscoring the necessity of long-term clinical/imaging surveillance. This case highlights the need for further studies to clarify pathophysiological links between COVID-19 and persistent autoimmune cerebellar degeneration.
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Hematology reportsParaneoplastic Cerebellar Syndrome Revealing Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer: A Case Report.
CureusParaneoplastic Cerebellar Degeneration from Subclinical Breast Cancer on Mammography.
JMA journalA Rare Presentation of Dizziness: Vestibular Testing in Paraneoplastic Cerebellar Degeneration.
Journal of the American Academy of AudiologyA case of Anti-Hu and Anti-Zic4 paraneoplastic cerebellar degeneration in a patient with stage IV adenocarcinoma of Müllerian origin.
Gynecologic oncology reportsAutologous Hematopoietic Stem Cell Transplantation for Paraneoplastic Cerebellar Degeneration.
Neurology(R) neuroimmunology & neuroinflammationExacerbation of paraneoplastic cerebellar degeneration by immune checkpoint inhibitor use in endometrial cancer.
Gynecologic oncology reportsCDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization.
The Journal of cell biologyTremor and Ataxia in Paraneoplastic Anti-Diacylglycerol Lipase Alpha (DAGLA) Cerebellitis.
Cerebellum (London, England)Paraneoplastic cerebellar degeneration combined with Lambert-Eaton myasthenia gravis syndrome in a patient positive for SOX1 antibody.
American journal of translational researchDeep brain stimulation improves cerebellar tremor symptoms in paraneoplastic cerebellar degeneration: a case report.
BMC neurologyAutoimmune encephalitis associated with anti-SOX1 autoantibodies in COVID-19: A case report.
IDCasesImmune checkpoint inhibitor-associated paraneoplastic cerebellar degeneration in a case of extensive-stage small-cell lung cancer with pre-existing anti-SOX1 antibody.
The journal of medical investigation : JMIImaging in paraneoplastic neurological syndromes: a comprehensive review.
Japanese journal of radiologyCase Report: Anti-Yo antibody mediated paraneoplastic cerebellar degeneration in a patient with squamous cell lung carcinoma.
Frontiers in immunologySmall cell lung cancer progressing into fatal ascending motor and sensory polyneuropathy despite dramatic response to chemotherapy: A case report.
MedicineAre there any differences between adult-onset cerebellitis and childhood cerebellitis?
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyHodgkin lymphoma presenting as paraneoplastic cerebellar degeneration: A case report.
SAGE open medical case reportsParaneoplastic Neurologic Syndrome Associated with Fallopian Tube Cancer: A Case Report.
Case reports in oncologyLong-Term Survivor with Paraneoplastic Cerebellar Ataxia and Small-Cell Lung Cancer.
Journal of clinical medicineRoles of CDR2 and CDR2L in Anti-Yo Paraneoplastic Cerebellar Degeneration: A Literature Review.
International journal of molecular sciencesAtypical Presentation of Carcinoma Breast as Paraneoplastic Cerebellar Degeneration on [18F]FDG PET/CT.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaParaneoplastic cerebellar degeneration - raising awareness for early diagnosis.
Neurologia i neurochirurgia polskaCase report: paraneoplastic cerebellar degeneration associated with anti-Yo antibody successfully treated with ofatumumab.
Frontiers in immunologyAnti-Tr/DNER Antibody-associated Paraneoplastic Neurological Syndrome Presenting Limbic Encephalitis with Anaplastic Large Cell Lymphoma.
Internal medicine (Tokyo, Japan)Case report: anti-IgLON5 disease combined with paraneoplastic cerebellar degeneration with the detection of anti-sulfatide IgG antibody, masquerading as meningoencephalitis.
BMC neurologyParaneoplastic Syndromes of the Nervous System in Patients Suffering from SCLC. A Review of the Recent Literature.
Acta medica academicaFLOCCULAR SYNDROME- AN ATYPICAL PRESENTATION OF PARANEOPLASTIC CEREBELLAR DEGENERATION.
Journal of Ayub Medical College, Abbottabad : JAMCAltered exosomal miRNA profiles in patients with paraneoplastic cerebellar degeneration.
Annals of clinical and translational neurologyBlood-Brain Barrier Disruption in Neuroimmunological Disease.
International journal of molecular sciencesPerformance Assessment of the New EUROLINE Neurologic Syndrome 15 Ag (IgG) for the Determination of Autoantibodies Associated with Neurological Disorders.
NeurologyWhat we've learnt about autoimmune neurological diseases from neuropathology.
Revue neurologique"One a penny, two a penny", I saw the hot cross bun sign".
Clinical imagingImmune Checkpoint Inhibitor-Related Cerebellar Toxicity: Clinical Features and Comparison with Paraneoplastic Cerebellar Ataxia.
Cerebellum (London, England)Paraneoplastic neurological syndromes of small cell lung cancer.
Postepy psychiatrii neurologiiRecent advances in diagnosis of immune-mediated cerebellar ataxias: novel concepts and fundamental questions on autoimmune mechanisms.
Journal of neurologyParaneoplastic syndromes in patients with melanoma.
Postepy dermatologii i alergologiiParaneoplastic Cerebellar Degeneration Revealing Non-Small Cell Lung Cancer: A Case Report.
CureusMulti-omics profiling reveals dysregulated ribosome biogenesis and impaired cell proliferation following knockout of CDR2L.
BMC cancerImmune Ataxias: The Continuum of Latent Ataxia, Primary Ataxia and Clinical Ataxia.
Journal of integrative neuroscience18F-FDG PET/CT in assessment of paraneoplastic cerebellar degeneration as the first sign of occult fallopian tube serous cystadenocarcinoma: Case report.
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der NuklearmedizinGynecologic clear cell carcinoma and paraneoplastic cerebellar Degeneration: A literature review and case study.
Gynecologic oncology reportsEpidemiology of paraneoplastic neurologic syndromes.
Handbook of clinical neurologyHematologic malignancies and hematopoietic stem cell transplantation.
Handbook of clinical neurologyParaneoplastic neurologic syndrome associated with gynecologic and breast malignancies.
Handbook of clinical neurologyParaneoplastic antibodies targeting intracellular antigens.
Handbook of clinical neurologyPathogenesis and immunopathology of paraneoplastic disorders.
Handbook of clinical neurologyParaneoplastic cerebellar and brainstem disorders.
Handbook of clinical neurologyParaneoplastic Cerebellar Degeneration Leading to an Early Diagnosis of Peritoneal Serous Papillary Carcinoma.
Internal medicine (Tokyo, Japan)[Blood-brain barrier breakdown and autoimmune cerebellar ataxia].
Rinsho shinkeigaku = Clinical neurologyParaneoplastic Cerebellar Degeneration Associated with Breast Cancer: A Case Report and a Narrative Review.
Brain sciencesOvarian mass Presenting as Paraneoplastic cerebellar degeneration with peripheral neuropathy and anti-Yo antibody.
BMJ case reportsCerebellar leptomeningeal enhancement: An imaging finding of rapidly progressive Purkinje cell cytoplasmic autoantibody type 1 paraneoplastic cerebellar syndrome.
Journal of neuroimmunologyCerebellar progressive multifocal leucoencephalopathy identified by the shrimp sign.
BMJ case reportsRecent Advances in Immune-Mediated Cerebellar Ataxias: Pathogenesis, Diagnostic Approaches, Therapies, and Future Challenges-Editorial.
Brain sciencesFavorable Outcomes in a Case of Non-paraneoplastic DNER Ataxia Treated with Immunotherapy.
Cerebellum (London, England)A not so incidental 'incidentaloma' - pediatric ganglioneuroma-associated cerebellar degeneration and super-refractory status epilepticus: case report and literature review.
Frontiers in neurologyCDR2 and CDR2L line blot performance in PCA-1/anti-Yo paraneoplastic autoimmunity.
Frontiers in immunologyAnti-Ma2 Antibody-Mediated Paraneoplastic Cerebellar Degeneration and Myeloneuropathy Secondary to Lymphoma.
Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology SocietyImmune-mediated ataxias: Guide to clinicians.
Parkinsonism & related disordersDetection of High-Risk Paraneoplastic Antibodies against TRIM9 and TRIM67 Proteins.
Annals of neurologyA retrospective study of autoimmune cerebellar ataxia over a 20-year period in a single institution.
Journal of neurologyParaneoplastic Cerebellar Degeneration Accompanied by Seropositivity for Anti-GAD65, Anti-SOX-1 and Anti-VGCC Antibodies Due to Small-cell Lung Cancer.
Internal medicine (Tokyo, Japan)Teaching NeuroImage: Paraneoplastic Cerebellar Degeneration and Antibodies to TRIM 9 and 67 Secondary to Melanoma.
NeurologyParaneoplastic Syndromes Associated with Gynecologic Neoplasms: Experience from a Tertiary Care Center in South India.
South Asian journal of cancer[Hodgkin's lymphoma: sensitive and autonomic neuropathy as a paraneoplastic manifestation].
Medicina[Immune-Mediated Cerebellar Ataxias].
Brain and nerve = Shinkei kenkyu no shinpoCerebellar Hypermetabolism in a Hodgkin Lymphoma Leads to Diagnosis of Paucisymptomatic Cryptococcus neoformans Meningitis.
Clinical nuclear medicineCase report: Anti-CARPVIII autoantibody-associated mixed dementia.
Frontiers in psychiatryAnti-Yo paraneoplastic cerebellar degeneration in a patient with stage IV ovarian adenocarcinoma during bevacizumab maintenance therapy.
BMJ case reportsAutoimmune cerebellar ataxia associated with anti-Purkinje cells antibodies: the next frontier of neuroimmunology.
Annals of translational medicineAnti-Zic4 Paraneoplastic Cerebellar Degeneration With Mesial Temporal Lobe Hyperintensity in a Patient With Papillary Thyroid Carcinoma: A Case Report and Review of the Literature.
CureusSeptin-3 autoimmunity in patients with paraneoplastic cerebellar ataxia.
Journal of neuroinflammationA cerebellar degeneration-related protein 2-like cell-based assay for anti-Yo detection in patients with paraneoplastic cerebellar degeneration.
European journal of neurologyA Pilot Study to Develop Paraneoplastic Cerebellar Degeneration Mouse Model.
Cerebellum (London, England)High-grade B-cell lymphoma with gastroduodenal involvement showing paraneoplastic cerebellar degeneration: a case report.
Translational cancer researchRapid-onset paraneoplastic cerebellar degeneration successfully treated by radiotherapy and tumorectomy.
International cancer conference journalAn Etiological Investigation of Paraneoplastic Cerebellar Degeneration in Ovarian Cancer Patients: A Systematic Review.
CureusNodular Sclerosing Hodgkin Lymphoma With Paraneoplastic Cerebellar Degeneration.
Federal practitioner : for the health care professionals of the VA, DoD, and PHSA Systematic Review on Anti-Yo/PCA-1 Antibody: Beyond Cerebellar Ataxia in Middle-Aged Women with Gynecologic Cancer.
Cerebellum (London, England)Pearls & Oy-sters: Vibration-Induced Downbeat Nystagmus: A New Cerebellar Sign Observed in Paraneoplastic Syndrome.
NeurologyRare Etiologies in Immune-Mediated Cerebellar Ataxias: Diagnostic Challenges.
Brain sciencesParaneoplastic Cerebellar Degeneration With P/Q-VGCC vs Yo Autoantibodies.
Neurology(R) neuroimmunology & neuroinflammationTreatable Ataxias: How to Find the Needle in the Haystack?
Journal of movement disordersCerebellar hypermetabolism: an alternative marker for diagnosis of paraneoplastic cerebellar degeneration.
NeurologiaAnti-Zic4 paraneoplastic cerebellar degeneration in a patient with EGFR-mutated NSCLC: a case report.
Translational lung cancer researchThe Discovery of Anti-Yo (Anti-PCA1) Antibody in Patients with Paraneoplastic Cerebellar Degeneration: Opening a Window into Autoimmune Neurological Disease.
Cerebellum (London, England)Immune and Genetic Signatures of Breast Carcinomas Triggering Anti-Yo-Associated Paraneoplastic Cerebellar Degeneration.
Neurology(R) neuroimmunology & neuroinflammationThe early diagnoses and treatment of anti-Yo antibody-mediated paraneoplastic cerebellar degeneration in a patient with breast cancer: a case report.
Translational cancer researchAutoimmune Cerebellar Ataxia: Etiology and Clinical Characteristics of a Case Series from China.
Cerebellum (London, England)What is in the Neuromuscular Junction Literature?
Journal of clinical neuromuscular diseaseParaneoplastic cerebellar degeneration with anti-Yo antibodies and an associated submandibular gland tumor: a case report.
BMC neurologyExpanding the spectrum of SOX1-antibodies in neuropathy: the coexistence of anti-SOX1 and Guillain-Barré syndrome-a case report.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyParaneoplastic syndromes in ophthalmology.
Archivos de la Sociedad Espanola de OftalmologiaImmune-Mediated Cerebellar Ataxia Associated With Neuronal Surface Antibodies.
Frontiers in immunologyAnti-Ri-Associated Paraneoplastic Neurological Syndrome Revealing Breast Cancer: A Case Report.
CureusParaneoplastic Cerebellar Degeneration with Anti-CV2/CRMP5 Antibodies in Ovarian Cancer: Case Report and Review of the Literature.
Case reports in oncologyParaneoplastic Cerebellar Syndrome Presented as Cerebellar Hypermetabolism in a Patient With Occult Breast Carcinoma.
Clinical nuclear medicineAnti-Yo-Associated Paraneoplastic Cerebellar Degeneration: Case Series and Review of Literature.
CureusParaneoplastic cerebellar degeneration associated with anti-Yo antibodies in uterine papillary serous carcinoma.
International journal of gynecological cancer : official journal of the International Gynecological Cancer SocietyUpdate on Paraneoplastic Cerebellar Degeneration.
Brain sciencesExpression of cerebellar degeneration-related proteins CDR2 and CDR2L in human and rat brain tissue.
Journal of neuroimmunologyAnti-Tr/DNER Antibody-Associated Cerebellar Ataxia: a Systematic Review.
Cerebellum (London, England)Hodgkin Lymphoma With Diplopia and Nystagmus: A Paraneoplastic Cerebellar Degeneration With Ectopic Expression of DNER Antigen on Reed-Sternberg Cells.
Clinical lymphoma, myeloma & leukemiaCase Report: A False Negative Case of Anti-Yo Paraneoplastic Myelopathy.
Frontiers in neurologyParaneoplastic Cerebellar Degeneration with Demyelinating Polyradiculoneuropathy in a Case of Anti-Yo Antibody-Positive Breast Cancer.
Neurology IndiaUpdate in Autoimmune Movement Disorders: Newly Described Antigen Targets in Autoimmune and Paraneoplastic Cerebellar Ataxia.
Frontiers in neurology18F-FDG PET/CT Findings in a Rare Case of Paraneoplastic Vestibulocerebellar Syndrome Associated With Isolated Antiamphiphysin Antibodies.
Clinical nuclear medicineParaneoplastic Cerebellar Degeneration: A Dilemma Resolved with Positron Emission Tomography/Computed Tomography.
Indian journal of nuclear medicine : IJNM : the official journal of the Society of Nuclear Medicine, IndiaCD8 T-cell-mediated cerebellitis directed against Purkinje cell antigen after ipilimumab for small cell lung cancer.
Neuropathology and applied neurobiologyParaneoplastic neurological syndrome: an evolving story.
Neuro-oncology practiceParaneoplastic cerebellar degeneration in platinum-responsive endometrial cancer: A case report and review of literature.
Gynecologic oncology reportsParaneoplastic cerebellar syndrome secondary to rhabdomyosarcoma: a very rare aetiology.
NeurologiaPD-1-inhibitor-induced PCA-2 (MAP1B) Autoimmunity in a Patient with Renal Cell Carcinoma.
Cerebellum (London, England)Anti-Yo antibody-positive paraneoplastic cerebellar degeneration in a patient with possible cholangiocarcinoma: A case report and review of the literature.
World journal of clinical casesRecognition and management of rapid-onset gluten ataxias: case series.
Cerebellum & ataxiasAnti-Tr/DNER antibody paraneoplastic cerebellar degeneration preceding a very late relapse of Hodgkin Lymphoma after 12 years.
Cerebellum & ataxiasParaneoplastic Cerebellar Degeneration (PCD) associated with PCA-1 antibodies in established cancer patients.
Journal of neuro-oncologySimultaneous paraneoplastic cerebellar degeneration, Lambert-Eaton syndrome and neuropathy associated with AGNA/anti-SOX1 and VGCC antibodies.
Neurological research and practicePeriodic Alternating Gaze Deviation Due to Paraneoplastic Cerebellar Degeneration.
Movement disorders clinical practiceParaneoplastic cerebellar degeneration in a patient with multiple myeloma.
Leukemia & lymphomaInpatient vs Outpatient Evaluation of Suspected Paraneoplastic Cerebellar Degeneration.
Neurology. Clinical practiceLambert-Eaton Myasthenic Syndrome and Paraneoplastic Cerebellar Degeneration Associated with Merkel Cell Carcinoma with Unknown Primary: A Case Report.
Acta dermato-venereologicaVoltage-Gated Calcium Channel Antibody-Induced Oropharyngeal Dysphagia Presenting as a Paraneoplastic Neurological Complication in Breast Cancer.
CureusAutoantibodies Against the Purkinje Cell Protein RGS8 in Paraneoplastic Cerebellar Syndrome.
Neurology(R) neuroimmunology & neuroinflammationParaneoplastic Encephalitis Associated with Locally Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer.
Journal of breast cancerFDG PET Unveils the Course of Paraneoplastic Cerebellar Degeneration: A Semiquantitative Analysis.
Clinical nuclear medicineParaneoplastic cerebellar degeneration: Initial presentation of occult breast cancer.
The breast journalAcute-onset paraneoplastic cerebellar degeneration secondary to neuroendocrine carcinoma with atypical prognosis: a case report.
The Journal of international medical researchParaneoplastic cerebellar degeneration as a presenting manifestation of non-Hodgkin's lymphoma.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyParaneoplastic Cerebellar Degeneration: The Importance of Including CDR2L as a Diagnostic Marker.
Neurology(R) neuroimmunology & neuroinflammationParaneoplastic cerebellar degeneration associated with anti-Yo antibodies in an ovarian cancer case: A case report.
Gynecologic oncology reportsA Rare Coexistence of Paraneoplastic Cerebellar Degeneration: Papillary Thyroid Carcinoma.
Current oncology (Toronto, Ont.)Immune-Mediated Cerebellar Ataxias: Clinical Diagnosis and Treatment Based on Immunological and Physiological Mechanisms.
Journal of movement disordersImmune-mediated ataxia with cerebellar hemiatrophy and dystonia associated with Castleman disease.
Clinical neurology and neurosurgeryParaneoplastic Cerebellar Degeneration and Lambert-Eaton Myasthenic Syndrome with SOX-1 Antibodies.
Internal medicine (Tokyo, Japan)Paraneoplastic cerebellar degeneration associated with anti-protein kinase Cgamma antibodies in a Chinese patient.
Journal of neuroimmunologyImaging Review of Paraneoplastic Neurologic Syndromes.
AJNR. American journal of neuroradiologyBreast cancer associated with paraneoplastic cerebellar degeneration: A case series.
Indian journal of cancerAnti-SOX1 Antibodies in Paraneoplastic Neurological Syndrome.
Journal of clinical neurology (Seoul, Korea)Localization of CDR2L and CDR2 in paraneoplastic cerebellar degeneration.
Annals of clinical and translational neurologyPotential effect of intravenous immunoglobulin against paraneoplastic cerebellar degeneration in progressive ovarian cancer.
Gynecologic oncology reportsParaneoplastic Neurological Syndromes: Study of Prevalence in a Province of the Lombardy Region, Italy.
Journal of clinical medicineAnti-Ma-associated paraneoplastic cerebellar degeneration in a patient with nodular lymphocyte-predominant Hodgkin lymphoma: a case report.
BMC neurologyParaneoplastic cerebellar degeneration heralding recurrence of fallopian tube adenocarcinoma: A case report and literature review.
Gynecologic oncology reportsPlasma exchange for treating anti-Yo-associated paraneoplastic cerebellar degeneration: Case report and literature review.
MedicineParaneoplastic cerebellar degeneration diagnosed by anti-Yo determination in a young woman with early breast cancer.
BMJ case reports[Preliminary analysis of central paroxysmal positional vertigo].
Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgeryParaneoplastic Cerebellar Degeneration Secondary to BRAF Mutant Melanoma Metastasis from an Occult Primary Cancer.
Case reports in oncologyAntinuclear antibodies (ANA) patterns in paraneoplastic cerebellar degeneration during the course of disease and treatment protocols - A case report.
Journal of translational autoimmunityImmunological Bases of Paraneoplastic Cerebellar Degeneration and Therapeutic Implications.
Frontiers in immunologyTremor in Paraneoplastic Cerebellar Degeneration: Beyond Intention Tremor.
Annals of Indian Academy of NeurologyA Case of Paraneoplastic Cerebellar Degeneration that Preceded the Diagnosis of Classical Hodgkin's Lymphoma by 16 Months.
The American journal of case reportsTreatment of Primary Autoimmune Cerebellar Ataxia with Mycophenolate.
Cerebellum (London, England)Rhombencephalitis associated with isolated Zic4-antibodies in Paraneoplastic cerebellar degeneration: a case report.
BMC neurologyCDR2 and CDR2L Yo Antigens in Paraneoplastic Cerebellar Degeneration.
Annals of neurologyParaneoplastic encephalitis with leukoencephalopathy in primary fallopian tube carcinoma.
Radiology case reportsParaneoplastic cerebellar degeneration in a patient with breast cancer associated with carbonic anhydrase-related protein VIII autoantibodies.
Journal of neuroimmunologyParaneoplastic cerebellar degeneration: initial presentation of mucosa-associated lymphoid tissue lymphoma in a patient with primary Sjögren's syndrome.
Chinese medical journal[Vertigo as the first manifestation of ovarian cancer].
Nederlands tijdschrift voor geneeskundeParaneoplastic Cerebellar Degeneration in Diffuse Large B-cell Lymphoma and Review of Associated Onconeural Antibodies.
Clinical lymphoma, myeloma & leukemiaClinical spectrum and diagnostic pitfalls of neurologic syndromes with Ri antibodies.
Neurology(R) neuroimmunology & neuroinflammation[Ataxia - a group of heterogeneous diseases].
LakartidningenA case of acute cerebellar ataxia with two possible etiologies: viral cerebellitis and paraneoplastic antibody-positive ovarian cancer.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical NeurophysiologyCerebellar cortical degeneration associated with feline leukemia virus infection and cerebellar lymphoma in a young cat.
Open veterinary journalCombined Cerebellar and Spinal Cord Deficits Caused by an Underlying Gynecologic Malignancy.
Case reports in oncological medicine[Paraneoplastic subacute degeneration of the cerebellum in non-small cell lung cancer and positive anti-Tr3 antibodies].
Der NervenarztNon-small cell lung cancer associated with late-onset Lambert-Eaton myasthenic syndrome and paraneoplastic cerebellar degeneration.
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology[Paraneoplastic neurologic degeneration revealing ovarian cancer recurrence].
The Pan African medical journalEpidemiology of paraneoplastic neurological syndromes: a population-based study.
Journal of neurologyRare case of paraneoplastic cerebellar degeneration secondary to high-grade serous carcinoma of tubo-ovarian origin.
BMJ case reportsStroke-Like Presentation of Paraneoplastic Cerebellar Degeneration: a Single-Center Experience and Review of the Literature.
Cerebellum (London, England)A quaint masquerader of breast cancer: Paraneoplastic cerebellar degeneration.
Neurology IndiaParaneoplastic cerebellar degeneration as initial presentation of renal cell carcinoma.
Cerebellum & ataxiasSensitive demyelinating neuropathy associated with anti-Yo antibodies and papillary thyroid cancer.
Medicina clinicaCerebellar Ataxia With Extreme Photophobia Associated With Anti-SOX1 Antibodies.
The Neurohospitalist[Paraneoplastic cerebellar degeneration and primary fallopian cancer].
Gynecologie, obstetrique, fertilite & senologieGRP78 antibodies damage the blood-brain barrier and relate to cerebellar degeneration in Lambert-Eaton myasthenic syndrome.
Brain : a journal of neurologyCerebellar Hypermetabolism in a Case of Paraneoplastic Cerebellar Syndrome With the Primary Lymphoepithelial Carcinoma in Tonsil.
Clinical nuclear medicineParaneoplastic Cerebellar Degeneration in Nasopharyngeal Carcinoma: a Unique Association.
Cerebellum (London, England)CDR2L Is the Major Yo Antibody Target in Paraneoplastic Cerebellar Degeneration.
Annals of neurology'A Story Unheard': anti-Ta associated paraneoplastic cerebellar degeneration in a female.
Journal of community hospital internal medicine perspectivesIFN-γ is a therapeutic target in paraneoplastic cerebellar degeneration.
JCI insightVariant Guillain-Barré syndrome in a patient with Hodgkin lymphoma: AMSAN.
Turk pediatri arsiviThymic Carcinoma Associated with Cerebellar Degeneration.
European journal of case reports in internal medicine[Paraneoplastic Cerebellar Degeneration with Lambert-Eaton Myasthenic Syndrome: A Report of an Effectively Treated Case and Systematic Review of Japanese Cases].
Brain and nerve = Shinkei kenkyu no shinpoAnti-Yo antibody-mediated paraneoplastic cerebellar degeneration associated with cognitive affective syndrome in a patient with breast cancer: a case report and literature review.
Current oncology (Toronto, Ont.)Revisiting the Clinical Phenomenology of "Cerebellar Tremor": Beyond the Intention Tremor.
Cerebellum (London, England)Paraneoplastic Cerebellar Degeneration Associated With Ovarian Adenocarcinoma: A Case Report and Review of Literature.
Annals of Indian Academy of NeurologyLong-Standing evolution of paraneoplastic cerebellar degeneration in a diffuse large B-cell lymphoma.
Journal of the neurological sciencesThe utility of anti-SOX2 antibodies for cancer prediction in patients with paraneoplastic neurological disorders.
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Prolonged Anti-Zic4 Antibody-Positive Cerebellar Degeneration Following COVID-19 Infection.
- Paraneoplastic cerebellar degeneration from an isolated nodal clear cell carcinoma of suspected gynecologic origin: case report and literature review.
- Paraneoplastic Neuro-Ophthalmologic Symptoms as Initial Manifestation of Hodgkin Lymphoma.
- Autologous Hematopoietic Stem Cell Transplantation for Paraneoplastic Cerebellar Degeneration.
- CDR2 is a dynein adaptor recruited by kinectin to regulate ER sheet organization.
- Late-onset anti-Yo antibody-positive paraneoplastic cerebellar degeneration: a case report.
- Paraneoplastic Cerebellar Syndrome Revealing Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer: A Case Report.
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- ORPHA:623626(Orphanet)
- MONDO:0044877(MONDO)
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- Busca completa no PubMed(PubMed)
- Artigo Wikipedia(Wikipedia)
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