Integrated multi-omics analysis unveils microbiota-metabolite-host interactions and novel biomarkers for early diabetic kidney disease diagnosis.

AKT1 phosphorylates PRMT7 to promote GLUD1 methylation and gastric cancer progression.

Tissue and CD4 T cell subset dependence on the amino acid transporter SLC38A1.

The Gut Metabolite Phenylacetylglutamine Inhibits the Angiogenic Potential of Human Umbilical Vein Endothelial Cells Via the β-Adrenergic Receptor-LDHA Axis.

Glutaminase deficiency provides insight to the role of glutamine accumulation and neurotoxicity.

Α-Ketoglutarate ameliorates appendicitis by modulating Gln metabolism and inhibiting NF - κB signaling pathway.

Single-Cell RNA-Sequencing of Peripheral Blood Reveals Neutrophil Heterogeneity in Childhood ANCA-Associated Vasculitis.

From metabolism to mood regulation: astrocytes as a driver of depression.

The cross-linking activity of transglutaminase 2 drives α-Synuclein pathology in synucleinopathy models.

Expanded stoichiometric model of chondrocyte metabolism: response to cyclical shear and compressive loading.

Comparative 1H NMR Lipoprotein Profiling of Rheumatoid Arthritis and Systemic Lupus Erythematosus Patients Highlights Disease-Specific Lipoprotein Dysregulation.

Circulating gut microbial metabolites and risk of coronary heart disease: A prospective multi-stage metabolomics study.

Metabolic-based therapeutic strategies to treat Huntington's disease.

Root inoculation with Trichoderma harzianum primes metabolic and stress-response pathways underlying growth and resistance in Brassica rapa.

The Impact of Motor Symptom Asymmetry on the Relationship Between Non-Motor Manifestations and Neurometabolic Profiles in Parkinson's Disease.

Effects of in vitro fermentation of Astragalus polysaccharide on gut microbiota and neurotransmitter metabolites in patients with major depressive disorder.

Unravelling Structural and Metabolic Alterations in the Hippocampus and Anterior Cingulate Cortex Using Integrated MRI and MRS in Major Depressive Disorder.

Ageing promotes metastasis via activation of the integrated stress response.

Glutaminase 1 in Vascular Disease: Linking Metabolic Reprogramming to Atherosclerosis Progression and Stability.

Clear Cell Foci as Precursors of Hepatocyte Nuclear Factor 1-alpha-inactivated Hepatocellular Adenoma in a Metabolic Syndrome Mouse Model.

Identification of a novel apoB variant in a family exhibiting hypocholesterolemia: Mechanistic insights.

Bioinformatics Analysis Reveals ALDH5A1: A Novel Molecular Brake on Th17 Cell Pathogenicity in Systemic Lupus Erythematosus.

Chromium nitride nanozyme-enhanced lateral flow immunoassay for sensitive and selective detection of transglutaminase 2: Proof-of-concept toward liver cancer-related biomarker evaluation.

1,25D3 reprograms mitochondrial quality control via sirtuin and sensitizes glioblastoma to chemotherapy.

Glutamine antagonist DON attenuates chikungunya virus-induced myositis by suppressing inflammatory activation in a murine model.

Dysfunctional decidual CD2+CD4+T cells regulated by Rev-erbα - GFPT1 - GPI anchored CD58 axis of decidual stromal cells underlies sleep disturbance induced recurrent pregnancy loss.

Early-life adversity induces metabolic alterations in a rodent model of depression: a differential stress response perspective.

TGM2-mediated serotonylation in tumor endothelial cells promotes angiogenesis and tumor growth in colorectal cancer.

ALG8-Driven Metabolic Reprogramming in Polycystic Kidney Disease: A Systematic Synthesis of Evidence Linking Glycosylation Defects to Metabolic Signaling.

Modulatory Effect of Natural Antioxidants on Tissue Transglutaminase Levels in Olfactory Ensheathing Cells Exposed to Amyloid-β: Integrated Biochemical and Computational Analysis.

OXCT1-induced succinylation at K81 shields HADH from HSPA8-Mediated degradation in alveolar epithelial cells to attenuate lung ischemia-reperfusion injury.

α-Ketoglutarate protects against cartilage damage via epigenetically driven metabolic reprogramming in osteoarthritis models.

Phenylacetylglutamine is associated with diabetic retinopathy via transgelin-mediated ferroptosis in hyperglycemic retinal epithelial cells.

Changes in the cortical GABAergic inhibitory system in a Spinal Muscular Atrophy mouse model.

Neonatal Hyperoxia Induces Metabolic Reprogramming in Senescent Alveolar Macrophages, Leading to Persistent Lung Injury.

Metabolic Portrait of Breast Cancer in Mixed Saliva.

Urinary Amino Acid Profiling as a Non-invasive Diagnostic and Risk Stratification Tool in Prostate Cancer.

Genome-wide comparison analysis of Brucella attenuated vaccine strain BA0711 and Brucella wild-type strain M28 and establishment of a duplex qPCR differentiation method.

Plasma neurotransmitter-related metabolite alterations in adolescent major depressive disorder with and without psychotic features.

Acteoside targeting glutamine synthetase ameliorates doxorubicin-induced cardiotoxicity by inhibiting ferroptosis.

Serum amino acid levels are associated with brain hypometabolism in patients across the Alzheimer's disease continuum.

Lower serum threonine and glutamine levels could be a predictor for multiple sclerosis in pregnancy.

Metabolomic Analysis of Aqueous Humor to Predict Glaucoma Progression and Overall Survival After Glaucoma Surgery-The MISO II Study.

Serum GFAP and NfL augment a metabolomics-driven strategy for long-term prediction of multiple sclerosis progression.

Silmitasertib, an FDA-designated orphan CK2 inhibitor, ameliorates neuropathology and motor dysfunction in a Huntington's disease mouse model.

Potential urine NMR Metabolomic signatures for early diagnosis of paediatric tuberculosis.

ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression.

Sanhua essential oil exerts antidepressant effects in breast cancer-related depression by modulating metabolic pathways.

Unraveling the role of polyamine metabolism in postoperative delirium: insights into biochemical mechanisms and biomarker potential.

Simvastatin Targets PKM2 to Alter Metabolic Reprogramming in Hepatic Stellate Cells and Mitigate Liver Fibrosis.

Maternal Toxoplasma gondii Infection Perturbs Foetal and Maternal Foetal Interface Metabolism, Exposing the Foetus to Kynurenine.

Roles of immune cell metabolism in rheumatoid arthritis.

Gestational low carbamoyl phosphate suppresses TET2-mediated DNA demethylation and induces congenital heart disease in offspring.

3D reconstruction of human liver tissue at cellular resolution.

Lacto-N-triose II alleviates metabolic dysfunction-associated Steatotic liver disease via microbiota-dependent citrulline biosynthesis.

Integrating plasma metabolomics using UPLC-Q Exactive Orbitrap HRMS and targeted amino acid and neurotransmitter analysis in plasma and cerebrospinal fluid by LC-MS/MS to explore biomarkers in pregnancy women with insomnia.

Insights into changes in glutaminergic metabolites in the anterior cingulate cortex: A systematic review and meta-analysis of magnetic resonance spectroscopy in schizophrenia.

A canine PLP1 missense variant differentiates oligodendrocyte maturation in connatal and classical Pelizaeus-Merzbacher disease.

Immune cell dynamics and mechanisms of epithelial injury in celiac disease.

Modulation of glutamate metabolic reprogramming via Ras-Raf-MEK/ERK signaling alleviates immune inflammation of astrocytes in glaucomatous neurodegeneration.

Haikun Shenxi Capsule alleviates Alzheimer's disease by targeting mitophagy to clear turbidity toxin.

Metabolic reprogramming and immunosenescence: a new sight for glioma therapy.

Neurometabolics of the anterior cingulate cortex (ACC) in major depressive disorder (MDD): A systematic review and meta-analysis.

Dendrimer-Conjugated Glutamine Antagonist, D-TTM020, Ameliorates Brain Immune Dysregulation and Improves Neurobehavioral Deficits in the Mecp2-Deficient Mouse Model.

Carbonic anhydrases contribute to mitochondrial function, conidial development, and pathogenicity of Magnaporthe oryzae.

Statins halt polycystic liver disease by reprogramming metabolism and normalizing mitochondrial bioenergetics in cystic cholangiocytes.

MTFP1 drives pancreatic cancer liver metastatic colonisation by regulating mitochondrial metabolism reprogramming.

Overview of glutamine metabolism in stromal components of the tumor microenvironment and potential anti-tumor therapies.

Parents-child multiple sites of microbial and metabolic signatures in autism spectrum disorder.

Untangling amino acid metabolism in renal diseases: mechanisms, dysregulation, and critical gaps.

Histopathological Correlation in Suspected Celiac Disease: Linking Clinical, Serological, and Endoscopic Findings.

Mitochondrial DNA mutations and intercellular mitochondrial transfer in cancer: mechanisms, biological effects, and clinical potential.

Multi-omics insights into Shenling Baizhu Powder's amelioration of murine asthma through gut microbiota and Glutamine-GLS1 pathway.

Impact of obesity on aromatic amino acids and brain glucose during acute hyperglycemia.

Identification and validation of a glutamine metabolism-related gene signature as a diagnostic and therapeutic target in osteoarthritis through integrated multi-omics analysis.

Hyperbaric oxygen improves combined drug-induced hyperuricemia model in rats by remodeling gut microbiota and regulating host metabolism.

Magnetic resonance spectroscopy in hospitalised older people shows age and delirium-specific metabolic changes.

Decreased N-acetylaspartate plus N-acetyl-aspartyl-glutamate levels in the caudate of schizophrenia patients with tardive dyskinesia.

Neurotransmitter alterations in seasonal affective disorder.

Elucidation of Molecular Mechanisms of Lipid-Altered Cytotoxicity of TDP-43 Fibrils.

Glutamine transporter SLC1A5 inhibits autophagy-mediated CD276 degradation to promote esophageal cancer progression.

An integrative multi-omics study reveals glutamine metabolism dysregulation connecting Alzheimer's disease and age-related macular degeneration.

Retinal Müller glia alterations and their impact on ocular glymphatic clearance in an Alzheimer's disease mouse model.

The fall of the genome protectors triad: PBRM1, SETD2, and BAP1's impact on metabolism and immunity in clear cell renal cell carcinoma.

Enzyme-Responsive Hemostatic Elastin-like Polypeptides for Fibrin Stabilization and Coagulation Restoration in Thrombocytopenia.

Therapeutic Effect of Arginine, Glutamine and β-Hydroxy β-Methyl Butyrate Mixture as Nutritional Support on DSS-Induced Ulcerative Colitis in Rats.

The role of glutamine metabolism in cardiovascular diseases.

Microbial transglutaminase in food biotechnology: from biochemical mechanisms to industrial applications.

Transglutaminase 2 activation is involved in thoracic aortic dissection through disruption of endothelial adherens junctions.

EGO complex at 20: The Rag GTPase-TORC1 nutrient-sensing blueprint.

Fecal microbiota transplantation promotes Wnt3a-mediated hippocampal neurogenesis in a rat model of chronic cerebral hypoperfusion.

Glutamine enhances endothelial cell survival and vasodilation by increasing glutathione to reduce oxidative stress.

Association of a five-metabolite and early-symptom profile with Parkinson's disease and its clinical progression.

Exploring key genes in NAFLD linked to glutamine metabolism: A comprehensive analysis combining multi-omics, machine learning and SHAP.

GFP-free live neuron quantitative imaging reveals compartmentalization and growth dynamics of polyQ aggregates.

Metabolic vulnerabilities in ovarian cancer decoding the nexus between nutrient adaptation and therapy resistance.

Metabolic reprogramming during human neuron differentiation indicates glutaminase as a key determinant in Fragile X syndrome.

Inter-species variability in 4,4'-methylenedianiline metabolism: insights from human and rat precision-cut liverslices.

Shared signatures of alcohol-associated dysbiosis in humans and non-human primates.

Cytosolic Phosphoenoylpyruvate Carboxykinase Deficiency: Clinical, Biochemical, and Genetic Features of Five Non-Finnish Patients.

Persistent DNA methylation and down-regulation of homeostatic genes in astrocytes after pilocarpine-induced status epilepticus: implications for epileptogenesis.

Simultaneous determination of short-chain fatty acids and tryptophan metabolites by a propyl chloroformate- derivatized GC-MS approach.

Serology-based diagnosis of coeliac disease in secondary care: a single-centre study in Norway.

Investigating the molecular mechanisms of glutamine metabolism and mitochondria-related biomarkers in Alzheimer's disease through transcriptomics and experimental validation.

Multi-organ metabolic dysregulation and cecal microbiota alterations following black carbon exposure.

Genetic traits and diet triggering the iron-induced hepatic model of the idiopathic disorder sporadic porphyria cutanea tarda.

PIK3CG deficiency promotes metabolic reprogramming in pancreatic Cancer by suppressing GLS2-driven glutamine metabolism.

Multi-biofluid metabolomics coupled with gene network reveals stage-specific alterations in mild cognitive impairment and Alzheimer's disease in an ethnically mixed cohort.

The Association Between Amino Acids and the Onset and Progression of Type 2 Diabetes Mellitus: A Comprehensive Analysis Based on UK Biobank Database.

Elevated neurotransmitter levels in people with HIV are associated with attention function.

Ampelopsin preserves glutamate homeostasis against cerebral ischemia.

Gas chromatography-mass spectrometry-based plasma metabolomics analysis in hypertensive patients with Yin deficiency and Yang hyperactivity syndrome.

Mitochondrial proteomics reveals reductive metabolism dependent on glutamine in fibroblasts of idiopathic pulmonary fibrosis under hypoxia.

Dynamic Behavioral and Molecular Changes Induced by Chronic Restraint Stress Exposure in Mice.

ToF-SIMS Reveals Metformin-Driven Restoration of Hepatic Lipid and Amino Acid Profiles in a Type 2 Diabetes Rat Model.

Targeting the Glutaminolysis Pathway in Glaucoma-Associated Fibrosis.

Amino acid metabolic reprogramming: future prospects for cholangiocarcinoma therapy.

Glucose exposure suppresses brain aromatase and impairs retinal regeneration in zebrafish.

Unbiased metabolomics screening for potential biomarkers in patients with In-stent restenosis post percutaneous coronary intervention.

Amino acid metabolism modulates chronic kidney disease progression by mediating the aging process: Mechanistic insights and therapeutic interventions.

Ultramicronized palmitoylethanolamide restores astrocyte-neuron metabolic coupling and Klotho/FGF21 signaling in a triple-transgenic mouse model of Alzheimer's disease.

Untargeted Serum Metabolomics Reveals Differential Signatures in Gallstone-Associated and Gallstone-Free Gallbladder Cancer Variants.

FOXM1/FUS facilitates triple-negative breast cancer malignant progression and glutamine metabolism through mediating SLC7A5 transcription.

Pitolisant Inhibits Alcohol Drinking and Improves Withdrawal Negative Affect Through Lateral Habenula Histaminergic Signaling in Mice.

Integrated omics-based analysis reveals distinct microbial-metabolite interaction networks in eosinophilic and non-eosinophilic chronic rhinosinusitis with nasal polyps in a Chinese population.

Fatigue in major depression is linked to depression severity, not sleep duration or anterior cingulate cortex neurochemistry.

Advances in understanding, diagnosing, and treating hepatic encephalopathy: from epidemiology to emerging therapies.

Programmed cell death pathways in huntington's disease: spotlight on ferroptosis and pyroptosis.

Nickel refining fumes activate glutamine metabolism via the HIF-1α/Notch pathway to drive epithelial-mesenchymal transition in Beas-2B cells.

Glutamine metabolites promote the progression of cervical cancer by inducing M2 macrophage polarization.

Determination of N-Lactoyl-phenylalanine, phenylacetylglutamine and trimethylamine-N-oxide related metabolites in hypertensive patients by liquid chromatography-mass spectrometry and the application to blood pressure regulation.

Sustained hippocampal neuroinflammation and subsequent glutamatergic dysfunction in juvenile idiopathic arthritis: evidence from proton magnetic resonance spectroscopy (1H-MRS).

The metabolomic profile of psoriatic arthritis patients unveils the unbalance of disease-related molecules and pathways.

Integrative Single-Cell and Machine Learning Analysis Develops a Glutamine Metabolism-Based Prognostic Model and Identifies MSMO1 as a Therapeutic Target in Osteosarcoma.

Biomimetic Liposome Coloaded ES-Cu and PFK15 Amplify Cuproptosis through Inhibition of Glycolysis in Fibroblast-Like Synoviocytes for Rheumatoid Arthritis Therapy.

Transglutaminase-2 Promotes Microglial Synaptic Phagocytosis and Ameliorates Epileptic Seizures by Inhibiting ABCA1 Ubiquitination.

Elevated brain glutamine levels in adults with autism spectrum disorder: A 7T MRS study.

Association between mental health and MASLD molecular insights through metabolomics.

Integrated Multi-omics Analysis of Hub Genes and miRNA Interactions in Hypertrophic Cardiomyopathy.

Metabolic Reprogramming of Adaptive Immunity Induced by Viral Infections.

Multi-omics dissection of SNP-mediated immunometabolic signatures in Alzheimer's disease reveals a novel individual predictive model.

A Predictive Model of Duodenal Atrophy in Adults With Celiac Disease: Could Diagnostic Endoscopy Be Avoided?

Metabolic Astrocytic Support with Decanoic Acid Enhances Energy Metabolism in Alzheimer's Disease Models.

Interplay Between Glutamine Metabolism and Other Cellular Pathways: A Promising Hub in the Treatment of HNSCC.

SLC38A3 deficiency reveals a critical role of blood-derived glutamine in brain development.

NEDD4 suppresses ferroptosis in lung ischemia-reperfusion injury by ubiquitinating and degrading SLC1A5.

Differences of respiratory tract flora and metabonomic characteristics of lung lavage fluid in pneumoconiosis model rats.

Evaluation of GABAergic and Glutamatergic Levels in the Dorsal Anterior Cingulate Cortex of Patients With Bipolar Disorder: A Cross-Sectional 1H-MRS Study.

Metabolomic Markers and Pathways of Blood-Brain Barrier Damage: A Systematic Review.

Multifaceted roles of HDAC7 in disease and the evolving chemical toolkit for its modulation.

Polyacrylic acid, but not polyethylene glycol, induces metabolic reprogramming linked to pulmonary fibrosis in rats.

Role of Qrich1-mediated endoplasmic reticulum stress pathway in Berberine inhibition of NF-κB activation induced by cerebral ischemia-reperfusion injury.

The transaminase-ω-amidase pathway senses oxidative stress to control glutamine metabolism and α-ketoglutarate levels in endothelial cells.

Exploring the role of GLS1 in colorectal cancer progression through the glutamine metabolism-PI3K signaling-autophagy axis.

Celastrol delays the progression of hepatocellular carcinoma by suppressing SLC1A5-mediated glutamine dependence.

Cleavage of cellular substrate porcine gasdermin D by porcine torovirus 3C-like protease induces pyroptosis.

Causal effects of glutamine and lipid-related metabolites on alopecia areata: A 2-sample Mendelian randomization study.

Development of a glutamine-responsive MRI contrast agent.

Microbiota-sphingolipid pathway in generalized epilepsy: evidence from Mendelian randomization and clinical metabolomics.

Integrated multi-omics analysis of renal metabolism in domestic cats with spontaneous chronic kidney disease.

Ammonia reduces glutamine synthetase expression in astrocytes via activation of Hippo-YAP signaling pathways.

Glutamine: fructose-6-phosphate amidotransferase (GFAT) in the pathology of diseases: a review.

Identification of the function of the metabolite repair enzyme Nit1: the story of a collaboration with Arthur Cooper.

Diazepam modulates anterior cingulate glutamate levels in people at clinical high-risk for psychosis.

Elucidating time-resolved intracellular metabolic dynamics via label-free Raman microspectroscopy and 2D correlation spectroscopy.

Effects of Chronic Moderate Alcohol Intake on Metabolic Phenotypes and Gut Microbiota in Lean and Obese Mice with Distinct Dietary Structures.

Accessing Altered Metabolic Profile in Acute Deep Vein Thrombosis Through Nuclear Magnetic Resonance Spectroscopy.

NADPH Oxidase 4 and Metabolic Stress in Dahl Salt-Sensitive Rat Kidneys.

The astrocytic engine: Na+,K+-ATPase at the nexus of brain function and malfunction.

Multiomics analysis of neutrophils in SLE: insights from adult and paediatric disease.

A Remote-Controlled Nanopump Delivers Oxygen to Boost Energy Production in Osteoarthritis.

High matrix stiffness triggers the YAP-OPA1-TET1/3 loop to drive chemoresistance via enhanced nuclear-mitochondrial communication.

Skin manifestations in individuals with undiagnosed celiac seropositivity: a cross-sectional study.

Promoter demethylation and protein O-GlcNAcylation-mediated enhancement of fatty acid synthase contributes to hepatic steatosis and inflammation in MASLD.

Neurometabolic signatures of gastrointestinal symptoms in the insula of Crohn's disease patients: explorative findings from a 7T MRS study.

Three mammalian VDAC isoforms distinctly regulate mitochondrial function and proteome to maintain cell metabolism.

Infection with Helicobacter pylori and the age at onset of coeliac disease in the "HUNT4" survey.

Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia.

Use of non-bound proteinogenic amino acids to modulate the growth of pathogenic bacteria from broiler chickens.

Phosphodiesterase-4 Inhibition: An Experimental Approach to Overcome Drug Resistance in a Rotenone-Corneal 6 Hz Kindling Mouse Model of Drug-Resistant Epilepsy.

Altered biopterin-related cofactor metabolism in the aqueous humor of glaucoma patients.

SLBP promotes lung adenocarcinoma progression by inhibiting ferroptosis and reprogramming glutamine metabolism via FADS2 interaction.

Plasma amino acid profile in obese children, adolescents, and adults: similarities or differences - a narrative review.

Alterations in short-chain fatty acid-associated gut microbiota and tight junction integrity in adolescent major depressive disorder.

Fecal metabolomics in Crohn's disease reveal N-Acetylglutamine as a Th17/Treg modulator.

Indoxyl sulfate promoted glutamine metabolism and cell proliferation in urothelial carcinoma involving Runx2.

In Vivo Glx Measurements From GABA-Edited HERMES at 3 T Are Not Consistent With Those From Short-TE PRESS Across Scanners, Brain Regions, Diagnostic and Age Groups.

Role of metabolites in mediating the effect of gut microbiota on Crohn disease: A two-step Mendelian randomization (MR) study.

Integrative bioinformatics and machine learning approach unveils potential biomarkers linking coronary atherosclerosis and glutamine metabolism-associated gene.

Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation.

The Glutamine Metabolic Switch Influences the Response of Neonatal Intestinal Macrophages to Breast Milk.

Diagnostic Evaluation of Seronegative Celiac Disease.

Closing the evidence loop-membrane-lipid homeostasis and vesicular transport link DEHP exposure to endometriosis.

Potential glutamine metabolism-related biomarkers were identified in osteoarthritis by bioinformatics.

The effect of alpha lipoic acid and caffeine loaded into chitosan nanoparticles on the hypothalamic amino acid neurotransmitters in a rat model of obesity.

Conditional deletion of glutaminase 1 in Tnfrsf11a-expressing cells reduces bone mass and induces postnatal growth retardation in mice.

The role of continued immunoglobulin A monitoring in celiac disease management.

Gut Microbiotas, Plasma Metabolites, and Autism Spectrum Disorder: A Bidirectional Mendelian Randomization Analysis.

Metabolomics Signatures of Atherosclerosis in Cardiovascular Disease: A Narrative Systematic Review.

Cerebrospinal Fluid Neurotransmitters, Pterins, Folates and Amino Acids in Paediatric Onset Epilepsies: A Tertiary Centre Retrospective Cohort Study.