A Doença do Enxerto Contra o Hospedeiro Crônica (DECH) é uma complicação que pode acontecer depois de um transplante de células-tronco ou de medula óssea. Nela, as células do doador, que foram recém-transplantadas, atacam o corpo de quem recebeu o transplante. Os sintomas podem incluir erupções na pele (como manchas ou vermelhidão), feridas na boca, olhos secos, inflamação no fígado, formação de cicatrizes na pele e nas articulações, e danos aos pulmões. A causa exata da DECH crônica não é conhecida. Provavelmente, ela resulta de uma interação complexa entre as células do doador e as de quem recebeu o transplante, que é mediada pelo sistema de defesa do corpo (sistema imunológico). A DECH crônica é tratada com prednisona ou outros medicamentos anti-inflamatórios ou imunossupressores (que diminuem a ação do sistema de defesa do corpo) semelhantes.
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A Doença do Enxerto Contra o Hospedeiro Crônica (DECH) é uma complicação que pode acontecer depois de um transplante de células-tronco ou de medula óssea. Nela, as células do doador, que foram recém-transplantadas, atacam o corpo de quem recebeu o transplante. Os sintomas podem incluir erupções na pele (como manchas ou vermelhidão), feridas na boca, olhos secos, inflamação no fígado, formação de cicatrizes na pele e nas articulações, e danos aos pulmões. A causa exata da DECH crônica não é conhecida. Provavelmente, ela resulta de uma interação complexa entre as células do doador e as de quem recebeu o transplante, que é mediada pelo sistema de defesa do corpo (sistema imunológico). A DECH crônica é tratada com prednisona ou outros medicamentos anti-inflamatórios ou imunossupressores (que diminuem a ação do sistema de defesa do corpo) semelhantes.
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Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 2.707
A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia.
A second allogeneic (allo-)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant-related toxicity in highly pretreated patients. This retrospective multicenter study analyzed 75 pediatric patients enrolled in the PRSZT registry who underwent HSCT2 between 2011 and 2020. Indications for HSCT2 were relapse in 55 patients (73%) and graft failure in 16 patients (21%). In 4 patients (6%), the indication could not be clearly determined due to incomplete documentation. At 2 and 5 years, overall survival (OS) was 48% and 40%, while relapse-free survival (RFS) was 35.2% and 29.9%. Relapse was the leading cause of mortality, occurring in 36% of patients post-HSCT2, with a median time to relapse of 8.2 months. Univariate analysis identified a longer duration of remission after HSCT1 (>6 months) as a predictor of improved OS (p = 0.013) and chronic graft-versus-host disease (cGVHD) after HSCT2 as beneficial for OS (p = 0.034) and RFS (p = 0.024). In multivariate analysis, older age (>10 years) (HR: 2.778, p < 0.01) and precursor T-cell ALL (HR: 6.62, p = 0.001) were associated with inferior OS, as well as with inferior RFS (HR: 2.2, p = 0.03; HR: 3.89, p < 0.005), while male sex (HR: 0.354, p = 0.02) and ATG administration (HR: 0.35, p = 0.019) predicted improved OS. Despite high relapse rates, HSCT2 remains a potentially curative treatment in a subgroup of patients. These findings highlight the need for better patient selection and the integration of novel immunotherapeutic strategies to further improve outcomes.
Ferritin as a pre-transplant biomarker for post-transplant outcomes in allogeneic stem cell transplantation using post-transplant cyclophosphamide.
Iron overload, indicated by elevated ferritin, is a potentially modifiable risk factor in allogeneic hematopoietic cell transplantation (allo-HCT); however, its prognostic value remains uncertain. We evaluated whether pre-transplant ferritin (pre-TF) levels are associated with allo-HCT outcomes, including overall survival (OS), disease-free survival (DFS), relapse incidence, and GVHD incidence. We retrospectively analyzed 682 allo-HCT recipients transplanted between 2019 and 2022, with a median follow-up 37 months. Pre-TF was measured at a median of 17 days before allo-HCT. A time-dependent receiver operating characteristic analysis for 2-year OS defined the optimal pre-TF cut-off of 2209 µg/L (AUC 0.53, sensitivity 35%, specificity 75%). Propensity score matching (PSM) was performed at a 2:1 ratio (controls:cases, caliper 0.2), balancing pre-transplant characteristics to yield a matched cohort of 417 patients. The median pre-TF was 1159 µg/L. After PSM, 278 patients (66.7%, n=278/417) had low pre-TF (< 2209 µg/L), and 139 (33.3%) had high pre-TF (≥ 2209 µg/L). High pre-TF was associated with a higher relapse incidence (HR 1.484, 95% CI 1.019-2.160, p=0.039) and a lower incidence of moderate or severe chronic graft-versus-host disease (cGvHD) (HR 0.501, 95% CI 0.298-0.843, p=0.009). OS did not differ after PSM, and was primarily influenced by HCT-CI and conditioning intensity. No differences were observed in graft dynamics, immune reconstitution, or infections. An exploratory AML-specific analysis (cut-off of 2885 µg/L) showed similar patterns for DFS and cGvHD. Elevated pre-transplant ferritin identifies allo-HCT patients at a higher relapse risk and lower risk of cGvHD. These results suggest that ferritin may be associated with immunomodulatory effects that attenuate the graft-versus-leukemia effect while reducing graft-versus-host disease, although this requires further investigation. Clinically, ferritin may serve as a simple and accessible risk biomarker, warranting prospective validation with disease-specific thresholds and integration of functional iron measures.
Early Marrow Microenvironment Immune Patterns After Hematopoietic Stem Cell Transplant in Pediatric Acute Lymphoblastic Leukemia Are Associated with Later Development of Chronic GvHD and Relapse.
Hematopoietic stem cell transplant (HSCT) is a curative therapy for acute lymphoblastic leukemia (ALL), but its success is limited by chronic graft-versus-host disease (cGvHD) and disease relapse. A central challenge is uncoupling the graft-versus-leukemia (GvL) effect from cGvHD. Early changes in the bone marrow microenvironment following HSCT may offer a predictive window into these divergent outcomes. We conducted a retrospective, single-center, exploratory study on 14 pediatric ALL HSCT patients. Applying single-cell antibody-sequencing (AbSeq) on archived bone marrow aspirates collected 60-100 days post-HSCT, we evaluated immune patterns associated with the development of cGvHD or ALL relapse after day 114. cGvHD after day 114 was associated with upregulation of the endoplasmic reticulum (ER) stress transcription factor XBP1 in transitional B cell and IgM memory B cell populations, a minclehighPD1- neutrophil population, and exhausted LAG3+ effector memory T cells (TEM). ALL relapse after day 114 was associated with higher CD22, CD24, and ARG1 expression in M(IL-4)-like macrophages and exhausted TIGIT+ TEM. Results from this exploratory study suggest that marrow immune signatures of B cell ER stress preceding later development of cGvHD and macrophage-mediated immune evasion preceding relapse may potentially be early biomarkers for separating GvL from cGvHD in ALL HSCT. Validation with larger cohorts is warranted.
Neuromyelitis Optica Spectrum Disorder in a Pediatric Patient Following Haploidentical Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia.
This report describes a rare pediatric case of seronegative neuromyelitis optica spectrum disorder (NMOSD) following a second haploidentical hematopoietic stem cell transplantation (HSCT) for relapsed acute myeloid leukemia (AML). The neurological syndrome, featuring simultaneous optic neuritis and myelitis, emerged alongside classic chronic graft-versus-host disease (GVHD) manifestations (lichenoid oral changes, arthritis) on day +145 post-transplant. The diagnosis of seronegative NMOSD was established based on clinical and MRI findings, after exclusion of infectious etiologies and absence of aquaporin-4 IgG antibodies in blood and cerebrospinal fluid. Corticosteroids were avoided due to the risk of AML relapse. Instead, plasma exchange, immunotherapy with rituximab and cyclophosphamide, followed by intravenous immunoglobulin maintenance induced rapid neurological improvement and parallel resolution of GVHD symptoms. This case underscores the central nervous system as a target for alloimmunity and presents a successful steroid-sparing treatment strategy for NMOSD manifested after allogenic HSCT.
Tooth loss and oral health-related quality of life in a sub-cohort within the Chronic Graft-versus-Host Disease Consortium.
Chronic graft-versus-host-disease (cGVHD) is a major complication of allogeneic hematopoietic cell transplantation (alloHCT) that frequently affects the oral cavity with manifestations of oral mucosal inflammation, salivary gland hypofunction, and trismus. However, the long-term consequences of oral cGVHD on oral health outcomes are not defined. This report assesses long-term tooth loss and oral health-related quality of life (OHRQL) measures in patients who have received alloHCT. Participants were evaluated at an initial post-transplant dental visit which consisted of dental and periodontal examination, oral mucosal examination, and panoramic radiographs. The National Institutes of Health (NIH) Modified Oral Mucosa Rating Scale (OMRS) and World Health Organization (WHO) Oral Health Assessment for Adults were used for diagnosis and grading of oral cGVHD and dental status. Pre-transplant dental records were available and utilized to calculate tooth loss data. Participants also completed the Oral Health Impact Profile-14 (OHIP-14) questionnaire, the NIH mouth sensitivity score, the Lee Symptom Scale (oral cavity items), and the shortened summated Xerostomia Inventory (XI). This study enrolled 70 participants at a median of 8.8 years after alloHCT (range 6.7-11.8 years); 19 (27.1%) had no past oral cGVHD, 22 (31.4%) had past but no current oral cGVHD, and 29 (41.4%) had current oral cGVHD. Patients with current oral cGVHD had a mean tooth loss of 2.3, patients with past but no current oral cGVHD had a mean tooth loss of 1.0, and patients with no past oral cGVHD had a mean tooth loss of 2.1 (p=0.54, ANOVA). The mean overall OHIP-14 scores for the current, past but no current, and no past oral cGVHD groups were 13.6, 6.3, and 6.3, respectively (p=0.02, ANOVA). Oral cGVHD significantly impacted various aspects related to eating and meal choices. The rate of tooth loss was not definitively different based on past/current oral cGVHD status. Further efforts at mitigating the adverse impacts of oral cGVHD on nutrition and oral-health-related quality of life has the potential to improve the lives of alloHCT recipients.
Publicações recentes
[The influence of different collagenases on the analysis of immune cells in salivary glands of mice with chronic graft-versus-host disease].
Individualized decitabine dosing for post-HSCT maintenance in MDS and secondary AML from MDS: long-term outcomes from the PODAC trial and matched controls.
Chronic graft-versus-host disease after haploidentical transplantation in aplastic anemia: clinical characteristics, risk factors, and survival outcomes.
The Impact of Post-Transplant Interventions and Chronic GVHD on Survival in Myeloid Malignancies Harboring TP53 Alterations.
[Allogeneic hematopoietic stem cell transplantation in children's acute myeloblastic leukemia: Survival and relapse].
📚 EuropePMC2.269 artigos no totalmostrando 199
Serum vitamin d levels predict hospital-free days in outpatient allogeneic stem cell transplantation survivors: implications for long-term health outcomes.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in CancerConcerns regarding glomerular disease in chronic graft versus host disease (cGVHD).
NefrologiaOral Squamous Cell Carcinoma Secondary to Chronic Graft-versus-host Disease: Report of Three Cases.
The Tokai journal of experimental and clinical medicineA PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia.
Pediatric blood & cancerAn evaluation of axatilimab for the treatment of chronic graft-versus-host disease.
Expert opinion on biological therapyPost-transplant Cyclophosphamide Reduces Bronchiolitis Obliterans Syndrome Risk Through Chronic Graft-versus-Host Disease Prevention: A Multicenter Cohort Study.
Chest[Research Progress on the Impact of Donor-Recipient Sex on Prognosis after Allogeneic Hematopoietic Stem Cell Transplantation --Review].
Zhongguo shi yan xue ye xue za zhi[Clinical Analysis of Allogeneic Hematopoietic Stem Cell Transplantation for Very Early-Onset Inflammatory Bowel Disease Caused by IL-10RA Mutation].
Zhongguo shi yan xue ye xue za zhi[Efficacy and safety of basiliximab in gastrointestinal chronic graft-versus-host disease].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiFerritin as a pre-transplant biomarker for post-transplant outcomes in allogeneic stem cell transplantation using post-transplant cyclophosphamide.
Transplantation and cellular therapyChronic graft versus host disease in upper limb: Calling upper limb rehabilitation specialists for improving outcomes in patients.
Clinical hematology internationalEarly Marrow Microenvironment Immune Patterns After Hematopoietic Stem Cell Transplant in Pediatric Acute Lymphoblastic Leukemia Are Associated with Later Development of Chronic GvHD and Relapse.
International journal of molecular sciencesReal-World Outcomes of Ruxolitinib as Salvage Therapy in Steroid-Refractory Acute and Chronic Graft-Versus-Host Disease: A Multicenter Retrospective Observational Study from Turkey.
Journal of clinical medicineCurrent Diagnosis and Management of Ocular Graft-Versus-Host Disease at a Tertiary Cancer Center.
Journal of clinical medicinePleuroparenchymal Fibroelastosis Complicated by Pulmonary Alveolar Proteinosis After Peripheral Blood Stem Cell Transplantation.
Respirology case reportsNeuromyelitis Optica Spectrum Disorder in a Pediatric Patient Following Haploidentical Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia.
Blood cell therapyHaematopoietic stem cell transplantation outcomes for teenage and young adult patients with acute leukaemia: A British Society of Blood and Marrow Transplantation and Cellular Therapy registry study.
British journal of haematologyRethinking Immune Checkpoint Inhibition in Cancer.
Scandinavian journal of immunologyTooth loss and oral health-related quality of life in a sub-cohort within the Chronic Graft-versus-Host Disease Consortium.
Transplantation and cellular therapyDe novo and quiescent cGVHD are distinguishable in a prognostic biomarker panel.
Frontiers in immunologyChronic graft-versus-host disease: Current situation and unmet needs - A European position statement.
Bone marrow transplantationEffect of vitamin D replacement on nutritional status and muscle strength in patients after allogeneic stem cell transplantation and chronic graft-versus-host disease.
Clinical nutrition ESPENSpanish real-world experience with belumosudil for chronic graft-versus-host disease after two or more prior lines of therapy.
Transplantation and cellular therapyRuxolitinib as a Steroid-Sparing Treatment for Chronic Graft-Versus-Host Disease.
Transplantation and cellular therapyNeurological sequelae of chronic graft-versus-host disease: clinical spectrum and management considerations.
Internal medicine journalThe efficacy and safety of MSCs in GVHD prevention and the treatment of SR-aGVHD: a systematic review and meta-analysis of randomized controlled trials.
Stem cell research & therapyHaploidentical Hematopoietic Stem Cell Transplantation With Anti-Thymocyte Globulin in the Treatment of Older Adults With Hematological Malignancy.
EJHaemEvaluation of corneal epithelial thickness mapping via spectral-domain OCT in patients after allogeneic haematopoietic stem cell transplantation.
The British journal of ophthalmologyLymphocyte subset reconstitution and clinical outcomes following haploidentical hematopoietic stem cell transplantation.
British journal of cancerBET inhibition blunts antibody production and macrophage-mediated fibrosis to restore lung function in murine cGVHD.
BloodBronchiolitis Obliterans Syndrome Following High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation in a Pediatric Patient With Neuroblastoma.
CureusChronic graft-versus-host disease suppressing CD56brightPerforinneg regulatory-like NK cells inhibit CD4+ T cells via PD-1, LAG-3, and TRAIL.
CytotherapySecondary Neoplasm in Survivors of Childhood Hematological Malignancies-Systematic Review.
Children (Basel, Switzerland)Optimizing Haploidentical Donor Selection for Pediatric Hematopoietic Cell Transplant.
Journal of clinical oncology : official journal of the American Society of Clinical OncologyStem-like memory-T maintenance and differentiation into tissue-resident T cells sustain chronic graft-versus-host disease in mice.
Nature communicationsA Pilot Clinical Trial of a Group Coping Intervention for English and Spanish Speakers with Chronic Graft-Versus-Host Disease.
Research squareRuxolitinib in treatment-naive or corticosteroid-refractory pediatric patients with chronic graft-versus-host disease: final analysis of the phase 2 REACH5 trial.
HaematologicaReal-world outcomes in refractory chronic graft-versus-host disease: the Italian multicenter experience with belumosudil.
HaematologicaAvoidance of related donors in CAEBV with germline immune variants: long-termoutcome of matched unrelated donor HSCT - a case report.
Annals of hematologyLongitudinal Study of Late Acute and Chronic Graft-Versus-Host Disease after Allogeneic Hematopoietic Cell Transplantation: A Long-Term Follow-up Study from the Chronic Graft-Versus-Host Disease Consortium.
Transplantation and cellular therapyInhibition of ROCK2 impedes osteoclastogenesis through Src-Ca2+-NFATc1 signaling pathway and alleviates ovariectomy-induced bone loss.
International immunopharmacologyThe BIOPREVENT machine-learning algorithm predicts chronic graft-versus-host disease and mortality risk using posttransplant biomarkers.
The Journal of clinical investigationGastrointestinal-localized polymorphic post-transplant lymphoproliferative disorder following kidney transplantation after allogeneic hematopoietic stem cell transplantation: a rare case report.
Clinical journal of gastroenterologyProposal for Diagnostic Criteria for Manifestations of Chronic Graft-versus-Host Disease in Peripheral Nervous System and Muscles.
Transplantation and cellular therapyChronic graft-versus-host disease has similar or worse impact on skin-specific quality of life than autoimmune connective tissue diseases: A cross-sectional study.
Journal of the American Academy of DermatologyRecent advances in the pathophysiology of acute and chronic graft-versus-host disease.
International journal of hematologyTreosulfan/fludarabine versus thiotepa/busulfan/fludarabine for allogeneic haematopoietic cell transplantation in lymphoma in the post-transplant cyclophosphamide era: A GETH-TC study.
British journal of haematologyExpanding the clinical spectrum of interleukin-2 receptor alpha chain deficiency: two novel cases with long-term hematopoietic stem cell transplantation outcome and literature review.
Frontiers in immunologyClinical Characteristics and Treatment Outcomes of Autoimmune-Like Hepatitis After Allogeneic Hematopoietic Stem Cell Transplantation.
Transplantation and cellular therapyPhagocytic Mesothelial Cells in Pericardial Effusion Following Allogeneic Peripheral Blood Stem Cell Transplantation for Chronic Active Epstein-Barr Virus Infection: A Distinctive Cytomorphological and Immunocytochemical Case Study.
Diagnostic cytopathologyPhase I/II Trials of Donor Regulatory T Cells for the Treatment of Steroid-Refractory Chronic Graft versus Host Disease.
Blood advancesEfficacy and safety of belumosudil for refractory chronic graft-versus-host disease in routine practice.
Annals of hematologyA Case Report of HLA 5/10 Cord Blood Cell Engraftment in a Patient with Severe β Thalassemia after Haplo-Cord Stem Cell Transplantation.
Annals of clinical and laboratory scienceThe outcomes of isoniazid prophylaxis in LTBI high-risk pediatric patients undergoing hematopoietic stem cell transplantation.
BMC infectious diseasesConcurrent pulmonary aspergillosis and phaeohyphomycosis due to Verruconis spp. in a stem cell transplant recipient with chronic graft-versus-host disease.
Medical mycology case reportsSevere brain atrophy after allogeneic hematopoietic stem cell transplantation in a patient suffering from chronic graft-versus-host disease.
Internal medicine (Tokyo, Japan)WITHDRAWN: Correction to Chronic graft-versus-host disease. Part II: Disease activity grading and therapeutic management [Journal of the American Academy of Dermatology 2024 Jan;90(1)19-36].
Journal of the American Academy of DermatologyWITHDRAWN: Correction to Chronic graft-versus-host disease. Part I: Epidemiology, pathogenesis, and clinical manifestations [Journal of the American Academy of Dermatology 2024 Jan;90(1)1-16].
Journal of the American Academy of DermatologyNovel R Shiny Tool for Survival Analysis With Time-Varying Covariate in Oncology Studies: Overcoming Biases and Enhancing Collaboration.
JCO clinical cancer informaticsThe Effect of Smoking and Pre-Allogeneic Hematopoietic Cell Transplant Pulmonary Comorbidity on the Incidence of Lung Graft-Versus-Host Disease and Post-Transplant Outcomes.
CancersMesenchymal Stem/Stromal Cells: A Review for Its Use After Allogeneic Hematopoietic Stem Cell Transplantation.
BiomoleculesBTK Inhibition in Hematology: From CLL/SLL to Emerging Applications Across B-Cell and Immune Disorders.
BiomoleculesOptimal Treatment of Steroid-refractory Chronic Graft-versus-host Disease (cGvHD) in the Era of Novel drugs - a Systematic Review and Meta-analysis.
Stem cell reviews and reportsBidirectional Interactions: Microbiome and Immune System Function in Cutaneous Graft-Versus-Host Disease.
Annals of plastic surgeryIntensification of Treosulfan-Fludarabine Conditioning With Thiotepa Exhibited Effectiveness and Tolerability in Older or Comorbid Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant With Active Myeloid Neoplasm: A Real-world Study.
Transplantation directChronic graft-versus-host disease in the era of post-transplant cyclophosphamide.
HaematologicaReal world experience using belumosudil for treatment of chronic graft versus host disease in children and young adults.
Bone marrow transplantationChronic graft-versus-host disease in long-term survivors of childhood leukemia.
HemaSphereBridging With Chimeric Antigen Receptor T-Cell Therapy or Chemotherapy to Allo-HSCT in B-ALL: A Comparison of Treatment Complications and Survival.
European journal of haematologyComparable outcomes of HSCT up-front and after failure of IST in pediatric aplastic anemia in recent years.
Blood advancesOrgan Responses, Survival, and Safety of Belumosudil in Chronic Graft-Versus-Host Disease: A Systematic Review and Meta-Analysis.
Clinical transplantationAutoimmune HLA alleles and neoantigens predict myelodysplastic syndrome outcomes after allogeneic HSCT: A CIBMTR analysis.
iScienceToward Better Response Assessment of Cutaneous Chronic Graft-Versus-Host Disease: A Report from the National Institutes of Health Consensus Project Task Force.
Transplantation and cellular therapyVULVO-Vaginal Chronic Graft-Versus-Host Disease Assessment: A Single-Center Prospective Observational Study.
European journal of haematologyChronic Graft-versus-Host Disease: A Review of Current Treatments beyond Second-Line and Emerging Therapies.
Acta haematologicaBruton tyrosine kinase inhibitors and invasive aspergillosis and mucormycosis: a case report and multi-center exploratory retrospective study.
ASM case reports[Prognostic Value of Dynamic Monitoring of WT1 Expression Levels for Relapse and Overall Survival in AML Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplantation During First Complete Remission].
Zhongguo shi yan xue ye xue za zhiIncidence, Risk Factors, and Treatment of Autoimmune Cytopenia Following Pediatric Allogeneic Hematopoietic Stem Cell Transplantation.
Journal of transplantationLong-Term Health Outcomes in Male Survivors of Childhood Cancer After Hematopoietic Stem Cell Transplantation: A Registry-Based Study.
Pediatric hematology and oncologyRuxolitinib Plus Extracorporeal Photopheresis for Steroid-Refractory Acute and Chronic Graft-Versus-Host Disease.
Journal of clinical medicine researchProposal for Diagnostic Criteria for Manifestations of Chronic Graft-versus-Host Disease in the Central Nervous System.
Transplantation and cellular therapyIbrutinib oral suspension bioavailability and compatibility for optimal enteral administration route.
Therapeutic advances in hematologyDetection and Management of Invasive Mold Disease in Pediatric Hematological Cancer Patients.
Infection and drug resistanceThe Effect of Chronic Graft-Versus-Host Disease and Its Therapy on Salivary Caries Risk Factors-An Exploratory Cross-Sectional Pilot Study.
Healthcare (Basel, Switzerland)Improving U-Net Segmentation of Cutaneous Chronic Graft-Versus-Host Disease in Clinical Photographs with Semi-Supervised Training.
Proceedings of SPIE--the International Society for Optical EngineeringIntravenous immunoglobulin for cutaneous chronic graft-versus-host disease.
JAAD case reportsSpatial Transcriptomics Analysis of Macrophage-to-Myofibroblast Transition in Bronchiolitis Obliterans Following Hematopoietic Stem Cell Transplantation.
Transplantation and cellular therapyParvovirus B19 infection induces pure red cell aplasia after lung transplantation.
Journal of infection and chemotherapy : official journal of the Japan Society of ChemotherapyFDA Approves Axatilimab: A New Standard in Chronic Graft-Versus-Host Disease Therapy.
JPMA. The Journal of the Pakistan Medical AssociationPosttransplant cyclophosphamide in HLA-matched peripheral blood transplantation: what's next?
BloodRelationship between gammopathies, chronic graft-versus-host disease, and survival probability after allogeneic hematopoietic cell transplantation.
Polish archives of internal medicineAxatilimab Immunogenicity and Clinical Relevance in Patients with Chronic Graft-Versus-Host Disease.
Clinical pharmacology and therapeuticsReal-World Effectiveness of Recombinant Zoster Vaccine in Allogeneic Hematopoietic Cell Transplant Recipients.
Transplantation and cellular therapyHigher HLA-DRB1 Evolutionary Divergence Is Associated with Reduced Relapse and Improved Survival after Matched Unrelated Hematopoietic Cell Transplantation.
Transplantation and cellular therapyRecombinant human soluble thrombomodulin prevents murine sclerodermatous chronic graft-versus-host disease.
Journal of immunology (Baltimore, Md. : 1950)Pre- and post-transplant extramedullary involvement in adult patients with t(8;21)(q22;q22) acute myeloid leukemia: incidence, risk factors and outcomes.
Leukemia & lymphomaFeasibility of early tacrolimus initiation in haploidentical-PBSCT with post-transplant cyclophosphamide after melphalan-based conditioning regimen.
Blood cell therapy[Antibody-dependent pathogenesis and GVL induction mediated by DBY/HLA class II complex in chronic GVHD].
[Rinsho ketsueki] The Japanese journal of clinical hematologyA Systematic Review of Treatments for Cutaneous Chronic Graft-versus-Host Disease.
Actas dermo-sifiliograficas[Methodological appraisal of statistical approaches to evaluating the impact of chronic graft-versus-host disease on mortality after hematopoietic stem cell transplantation].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiModel-based antithymocyte globulin dosing in ex vivo CD34+ selected allogeneic haematopoietic cell transplantation: a single-centre, single-arm, phase 2 study.
The Lancet. HaematologyA Case of Secukinumab in the Treatment of Psoriasis-Like Cutaneous Chronic Graft-versus-Host Disease.
Case reports in dermatologyTreosulfan-Based Conditioning Regimens for Allogeneic Hematopoietic Cell Transplantation in Acute Myeloid Leukemia and Other Myeloid Malignancies.
Pharmaceuticals (Basel, Switzerland)Cerebrospinal fluid profile associated with the incidence and outcomes of patients with chronic graft-versus-host disease after haploidentical hematopoietic stem cell transplantation.
Blood science (Baltimore, Md.)Symptoms of depression and anxiety in patients with transfusion-dependent thalassemia after hematopoietic stem cell transplantation: a single-center study.
Therapeutic advances in hematologyExtracorporeal Photopheresis for Chronic Graft-Versus-Host Disease According to 2014 NIH Consensus Criteria.
Journal of clinical apheresisRuxolitinib as second-line therapy for bronchiolitis obliterans syndrome after hematopoietic cell transplantation: a retrospective multicenter study.
Annals of hematologyCan Posttransplant Cyclophosphamide Reduce the Risk of Graft-Versus-Host Disease for Pediatric Fully Matched Nonrelated Stem Cell Transplant?
Experimental and clinical transplantation : official journal of the Middle East Society for Organ TransplantationAdvances in treatment of chronic graft-versus-host disease.
International journal of hematologyBelumosudil for Chronic Graft-Versus-Host Disease: A Systematic Review and Meta-Analysis.
Transplantation and cellular therapyCurrent therapeutics for sclerotic and fibrotic manifestations of chronic graft-versus-host disease.
Bone marrow transplantationLinezolid-mediated Prevention of Fibroblast Activation and Tissue Fibrosis via Mitochondrial Translation Inhibition.
Arthritis & rheumatology (Hoboken, N.J.)[Clinical Analysis of Cutaneous Chronic Graft-Versus-Host Disease Post-Allogeneic Hematopoietic Stem Cell Transplantation in Childhood].
Zhongguo shi yan xue ye xue za zhiEffect of Inflammatory Bowel Disease on Clinical Outcomes of Hematopoietic Cell Transplantation for Inborn Errors of Immunity.
Transplantation and cellular therapyDifferential impact of graft-versus-host disease on post-transplant outcomes of chronic myelomonocytic leukemia according to transplant procedures.
Leukemia researchPulmonary Complications Following Hematopoietic Cell Transplantation in Patients with Myelofibrosis: A Single-Center Retrospective Cohort Analysis.
Transplantation and cellular therapyToward Better and More Effective Clinical Trials for Chronic Graft-Versus-Host Disease.
Transplantation and cellular therapyLong-Term Follow-Up of the Baltimore Experience with Hematopoietic Cell Transplantation for Severe Aplastic Anemia Using Post-Transplantation Cyclophosphamide.
Transplantation and cellular therapyEffect of ruxolitinib on the oral mucosa in steroid-refractory graft-versus-host disease: a prospective observational exploratory study.
Clinical oral investigationsReproducibility and repeatability of the Myoton to quantify sclerotic chronic graft-versus-host disease.
Blood advancesControlling Renal Chronic Graft-Versus-Host Disease With a Belumosudil-Containing Regimen After Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report.
Pediatric blood & cancerMonoclonal and oligoclonal gammopathies secondary to allogeneic hematopoietic cell transplantation: a phenomenon associated with an increased survival and frequency of chronic graft-versus-host disease.
Polish archives of internal medicineExpansion of peripheral helper T cells in the peripheral blood of patients with chronic graft-versus-host disease.
Annals of hematologyLong-term outcomes of αβ T-cell/CD19 B-cell-depleted peripheral blood stem cell transplantation from unrelated donors in pediatric and adolescent patients with severe aplastic anemia: a single-center study.
CytotherapyRegulatory T-cell Activation Pathways in Patients With Chronic Graft-versus-host Disease Undergoing Extracorporeal Photopheresis Treatment: A Single-center Pilot Study.
In vivo (Athens, Greece)Opening New Horizons: Advanced Hematopoietic Stem Cell Expansion Strategies Bridging Cord Blood Therapy from Bench To Bedside.
Stem cell reviews and reportsNon-Markov Nonparametric Estimation of Complex Multistate Outcomes After Hematopoietic Stem Cell Transplantation.
Biometrical journal. Biometrische ZeitschriftMonitoring for paediatric pulmonary graft versus host disease with multiple breath washout.
ERJ open researchSalivary and Serum Cytokine Levels in Oral Chronic Graft-Versus-Host Disease: A Longitudinal Study on the Role of IL-6, IL-1α, and IL-17.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral PathologyCharacterizing CYP3A4-mediated drug interactions: a fixed-sequence pharmacokinetic Chinese study of posaconazole and ruxolitinib in haematological malignancies.
The Journal of antimicrobial chemotherapyPericardial effusion as a potential site of localized DNA virus reactivation following U-CB transplantation.
International journal of hematologyEfficacy and Safety of Belumosudil in the Treatment of Refractory Chronic Graft-Versus-Host Disease.
Transplantation and cellular therapyReal-world Canadian data on belumosudil therapy in heavily pretreated patients with steroid-refractory chronic graft-versus-host disease: treatment outcomes and risk factor analysis for failure-free survival.
Annals of hematology[Thiotepa-containing conditioning for allogeneic hematopoietic stem cell transplantation in children with inborn errors of immunity: a retrospective clinical analysis].
Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatricsImpact of Obesity and Weight-Based Chemotherapy Dosing Adjustments on Outcomes of Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia.
Transplantation and cellular therapyNoninfectious Severe Pulmonary Complications in Immunocompromised Critically Ill Patients.
Seminars in respiratory and critical care medicineCytogenetic risk-associated outcomes of antithymocyte globulin use in HLA-matched sibling transplantation for acute myeloid leukemia.
Annals of hematology[Strategies for the diagnosis and treatment of pulmonary chronic graft-versus-host disease after hematopoietic stem cell transplantation].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi[Effectiveness and safety of belumosudil in 20 patients with chronic graft-versus-host disease].
Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhiClinical profile and risk factors of low percent vital capacity after allogeneic hematopoietic stem cell transplantation.
CytotherapyReversible Bilateral Fixed Dilated Pupils in Hypercapnic Respiratory Failure Following Chronic Graft Versus Host Disease: A Case Report and Review of Literature.
Clinical case reportsTransplantation in patients with lower-risk MDS: a prospective phase 2 trial based on donor availability.
Blood advancesDistinct biological subtypes of chronic GVHD after pediatric hematopoietic cell transplantation.
BloodKidney failure in the course of focal segmental glomerulonephritis in a patient after alloHSCT - a case study and review of the literature.
Journal of nephrologyAllogeneic stem cell transplantation in chronic myelomonocytic leukemia: analysis of post-transplant survival and risk factors in 138 Mayo Clinic patients.
Blood cancer journalQuantifying the Clinical and Economic Burden of Graft-Versus-Host Disease Following Allogeneic Haematopoietic Stem Cell Transplantation in England: A Retrospective Cohort Study.
Advances in therapyExperience with second allogeneic hematopoietic stem cell transplantation in Chilean patients: A single-center study.
Hematology, transfusion and cell therapyReal-world experience of belumosudil and belumosudil/ruxolitinib combination in steroid-refractory chronic graft-versus-host disease.
Bone marrow transplantationILT-2 and ILT-4 expression and donor genotype as factors associated with HSCT outcome.
Clinical immunology (Orlando, Fla.)Efficacy of ibrutinib and diagnostic liver biopsy for idiopathic refractory ascites after allogeneic stem cell transplantation.
International journal of hematologySirolimus and Cyclosporine With Post-Transplant Cyclophosphamide or Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis in Unrelated Donor Hematopoietic Cell Transplantation.
Journal of clinical oncology : official journal of the American Society of Clinical OncologyRisk factors for bronchiolitis obliterans syndrome after hematopoietic stem cell transplantation: a systematic review and meta-analysis.
BMC pulmonary medicineIdentification of Distinct Subtypes in Immune Tolerance after Hematopoietic Cell Transplantation Using the Prospective ABLE1.0 Pediatric Study Cohort.
Transplantation and cellular therapyDevelopment and Validation of an HPLC-MS/MS Method for Determining I-BET151 in Rat Plasma and Its application to Pharmacokinetic Studies.
Drug design, development and therapyAcetyl-CoA carboxylase 1 inhibition increases Treg metabolism and graft-versus-host disease treatment efficacy via mitochondrial fusion.
The Journal of clinical investigationBlood proteomics for quantitative biomarkers of cellular therapies.
Biomarker researchCytokines Induced by Antithymocyte Globulin in Transplantation Conditioning and Associated Infusional Side Effects.
Transplantation and cellular therapyImmunization Strategies in Pediatric Patients Receiving Hematopoietic Cell Transplantation (HCT) and Chimeric Antigen Receptor T-Cell (CAR-T) Therapy: Challenges and Insights from a Narrative Review.
VaccinesCorneal subbasal nerve alterations and tear cytokine associations in ocular chronic graft-versus-host disease.
Frontiers in medicineExhausted-like effector CD8 T cells mediate immune-stromal interactions at mucosal Chronic Graft-versus-Host Disease onset.
bioRxiv : the preprint server for biologyPrognostic Impact of the Level of Minimal Residual Disease Prior to Allogeneic Hematopoietic Stem Cell Transplantation on Pediatric Patients With Acute Lymphoblastic Leukemia: A 10-Year Single-Center Study.
Clinical lymphoma, myeloma & leukemiaObesity Associations with Chronic Graft-Versus-Host Disease.
Transplantation and cellular therapyToll-Like Receptor Polymorphisms Influence Graft-Versus-Host Disease and Infection Risk After Single-Unit Cord Blood Transplantation for Adults.
European journal of haematologyProlonged Hematogone Expansion Is Associated with Better Outcomes in Allogeneic Hematopoietic Stem Cell Transplantation Recipients.
Hematology reports[Ruxolitinib - Acute or chronic graft-versus-host disease after corticosteroid failure].
Bulletin du cancerHaploidentical hematopoietic stem cell transplantation with post-transplant cyclophosphamide in the public Chilean national health system: A single center study.
Hematology, transfusion and cell therapyRisk biomarkers of chronic GVHD in children aged 10 years or younger and children/adults older than 10 years.
Blood advancesSclerotic GVHD and scleroderma share dysregulated gene expression that is ameliorated by EREG therapeutic antibody.
BloodEfficacy and Safety of Allogeneic Hematopoietic Stem Cell Transplantation in Curing Sickle Cell Disease: A Systematic Review and Meta-Analysis of Single-Arm Studies.
Transplantation and cellular therapyMachine-Learning Predictive Tool for the Individualized Prediction of Outcomes of Hematopoietic Cell Transplantation for Sickle Cell Disease: Registry-Based Study.
JMIR AIROCK 2 inhibition with belumosudil for the treatment of chronic graft-versus-host disease: a narrative review.
Therapeutic advances in hematologyVeno-Occlusive Disease in Very Young Children: A Profile of High Morbidity With Low Mortality.
Pediatric blood & cancerApproved and emerging therapies for glucocorticoid-refractory chronic graft-versus-host disease.
Current opinion in immunologyTaiwan consensus on pulmonary chronic graft-versus-host disease: A joint statement from the Taiwan Society of Blood and Marrow Transplantation (TBMT) and Taiwan Society of Pulmonary and Critical Care Medicine (TSPCCM).
British journal of haematologyIncreased Plasma ST2 Levels Precede the Development of Severe Acute GvHD and Chronic GvHD After Pediatric Hematopoietic Stem Cell Transplantation.
Pediatric blood & cancerMultiple Hematopoietic Stem Cell Transplantations in Pediatric Acute Myeloid Leukemia: Prognostic Significance of Remission and Severe Sinusoidal Obstruction Syndrome.
Pediatric blood & cancerDental plaque microbiota following allogeneic hematopoietic cell transplantation and risk of chronic graft-versus-host disease.
Haematologica[Effectiveness and safety of ibrutinib for steroid-dependent/refractory chronic graft-versus-host disease: a single-center analysis].
[Rinsho ketsueki] The Japanese journal of clinical hematologyExtracorporeal photopheresis reduces the T cell stimulatory capacity of human primary blood conventional dendritic cells type 1.
Frontiers in immunologySuccessful repeated endoscopic balloon dilatation for esophageal stricture as chronic graft-versus-host disease.
Annals of hematologyComprehensive analysis of serum immune complexes identifies chronic graft-versus-host disease-associated antigenic molecules: A study by the Nagasaki transplant group.
Human immunologyEfficacy and safety of belumosudil as compared with best available therapy for the treatment of cGVHD in the United States.
Blood advancesFecal microbiota transplantation for refractory chronic graft-versus-host disease after allogeneic hematopoietic cell transplantation: a pilot open-label, non-placebo-controlled study.
BMC medicine[Clinical analysis of hypomethylating agent in preventing relapse after allogeneic hematopoietic stem cell transplantation in high-risk acute myeloid leukemia].
Zhonghua er ke za zhi = Chinese journal of pediatricsSTARComm Scalably Detects Emergent Modules of Spatial Cell-Cell Communication in Inflammation and Cancer.
bioRxiv : the preprint server for biologyChronic Graft-versus-Host disease trends over 30 years - a study by the EBMT transplant complications working party.
Bone marrow transplantationNeurological manifestations of chronic graft versus host disease.
Internal medicine journalFirst Report of Hematopoietic Stem Cell Transplantation for Children Diagnosed with Wiskott-Aldrich Syndrome in Vietnam.
Journal of blood medicineThe Impact of Isolated HLA-DQB1 Mismatch and Donor Age in Unrelated Donor Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide.
Transplantation and cellular therapyBronchiectasis in Bronchiolitis Obliterans Syndrome after Hematopoietic Cell Transplantation.
Transplantation and cellular therapyRenal Involvement in Chronic Graft-Versus-Host Disease.
European journal of haematologyNew molecules in the therapy of chronic graft-versus-host disease.
Current opinion in hematologyVoriconazole-induced periostitis in a child with finger pain and nodules: case report and literature review.
BMC musculoskeletal disordersTargeting hypoxia-inducible factor 1α in chronic graft-versus-host disease to enhance graft-versus-leukemia responses: implications for nanotherapeutics.
Frontiers in immunologyOral Verruciform Xanthoma as a Manifestation of Chronic Graft-Versus-Host Disease in Fanconi Anemia: A Rare Case Report.
Special care in dentistry : official publication of the American Association of Hospital Dentists, the Academy of Dentistry for the Handicapped, and the American Society for Geriatric Dentistry[Therapeutic strategies for graft-versus-host disease in the new era].
[Rinsho ketsueki] The Japanese journal of clinical hematologyOptimizing Timing and Preparation for Allogeneic Hematopoietic Stem Cell Transplantation in Higher-Risk Myelodysplastic Syndromes.
Blood and lymphatic cancer : targets and therapyUnveiling new horizons in severe aplastic anemia management: a two-decade study on intensive immunosuppressive therapy combined with unrelated cord blood efficacy.
Frontiers in immunologyCutaneous Chronic Graft-Versus-Host Disease.
Mayo Clinic proceedingsAssociações
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia.
- Ferritin as a pre-transplant biomarker for post-transplant outcomes in allogeneic stem cell transplantation using post-transplant cyclophosphamide.
- Early Marrow Microenvironment Immune Patterns After Hematopoietic Stem Cell Transplant in Pediatric Acute Lymphoblastic Leukemia Are Associated with Later Development of Chronic GvHD and Relapse.
- Neuromyelitis Optica Spectrum Disorder in a Pediatric Patient Following Haploidentical Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia.
- Tooth loss and oral health-related quality of life in a sub-cohort within the Chronic Graft-versus-Host Disease Consortium.
- [The influence of different collagenases on the analysis of immune cells in salivary glands of mice with chronic graft-versus-host disease].
- Individualized decitabine dosing for post-HSCT maintenance in MDS and secondary AML from MDS: long-term outcomes from the PODAC trial and matched controls.
- Chronic graft-versus-host disease after haploidentical transplantation in aplastic anemia: clinical characteristics, risk factors, and survival outcomes.
- The Impact of Post-Transplant Interventions and Chronic GVHD on Survival in Myeloid Malignancies Harboring TP53 Alterations.
- [Allogeneic hematopoietic stem cell transplantation in children's acute myeloblastic leukemia: Survival and relapse].
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:99921(Orphanet)
- MONDO:0020547(MONDO)
- GARD:10964(GARD (NIH))
- Busca completa no PubMed(PubMed)
- Q111329725(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
