Raras
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Espasmo hemifacial clônico
ORPHA:221083CID-10 · G51.3CID-11 · 8B88.2OMIM 141405DOENÇA RARA

Mioclonia primária rara caracterizada por contrações progressivas, involuntárias, irregulares e clónicas ou tónicas dos músculos inervados pelo nervo facial (nervo craniano VII). Os sintomas são tipicamente estritamente unilaterais, persistem sobretudo durante o sono e ocorrem frequentemente na região do músculo orbicularis oculi, espalhando-se gradualmente para outras partes da metade da face afetada à medida que a doença progride. Estão reportadas formas familiares e adquiridas.

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Introdução

O que você precisa saber de cara

📋

Mioclonia primária rara caracterizada por contrações progressivas, involuntárias, irregulares e clônicas ou tônicas dos músculos inervados pelo nervo facial (nervo craniano VII). Os sintomas são específicos unilaterais, persistem sobretudo durante o sono e ocorrem frequentemente na região do músculo orbicular dos olhos, espalhando-se gradualmente para outras partes da metade da face afetada à medida que a doença progride. Estão reportadas formas familiares e adquiridas.

Pesquisas ativas
3 ensaios
25 total registrados no ClinicalTrials.gov
Publicações científicas
2.692 artigos
Último publicado: 2026 Apr 13

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-5 / 10 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
10.95
Worldwide
Início
Adult
+ elderly
🏥
SUS: Cobertura mínimaScore: 15%
CID-10: G51.3
🇧🇷Dados SUS / DATASUS
PROCEDIMENTOS SIGTAP (2)
0202010694
Sequenciamento completo do exoma (WES)genetic_test
0301070040
Atendimento em reabilitação — doenças rarasrehabilitation
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Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Características mais comuns

Espasmo hemifacial
Anormalidade do sistema nervoso
Herança autossômica dominante
3sintomas
Sem dados (3)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 3 características clínicas mais associadas, ordenadas por frequência.

Espasmo hemifacialHemifacial spasm
Anormalidade do sistema nervosoAbnormality of the nervous system
Herança autossômica dominanteAutosomal dominant inheritance

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico2.692PubMed
Últimos 10 anos200publicações
Pico2025130 papers
Linha do tempo
2026Hoje · 2026🧪 2004Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

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Genética e causas

O que está alterado no DNA e como passa nas famílias

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Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

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Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
Aprovado2
3Fase 32
2Fase 21
·Pré-clínico15
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 20 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Espasmo hemifacial clônico

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Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

1 pesquisa recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

25 ensaios clínicos encontrados, 3 ativos.

Distribuição por fase
NCT07135024 · Prospective Register Study to Assess Eligibility for and Eff…Em breve
NCT04589364 · Study of Abobotulinum Toxin Versus Neubotulinum Toxin Inject…Em breve
PHASE3
NCT04645277 · Magnetic Resonance Imaging Study on Patients With Hemifacial…UNKNOWN
NCT05103202 · Efficacy and Safety of 10-Week or Shorter vs 12-Week or Long…Concluído
NCT04621578 · Transcutaneous Electrical Acupoint Stimulation on Postoperat…Concluído
NA
NCT04474977 · Microvascular Decompressive Surgery for Hemifacial SpasmUNKNOWN
NCT00276315 · Assessment of Effectiveness and Safety of Dysport® for the T…Concluído
PHASE3
NCT00210431 · Post Marketing Surveillance Study of DysportConcluído
NCT03508882 · Pretarsal Versus Preseptal Botulinum Toxin for Patients With…Concluído
PHASE4
NCT02761096 · Effect of Acupuncture on Inflammation and Immune Function Af…Concluído
NA
NCT03390803 · Effect of Hemifacial Spasm on Intraocular Pressure Measureme…Concluído
NCT03306940 · Botulinum Toxin A in the Treatment of Hemifacial SpasmUNKNOWN
NA
NCT01932255 · CSF Leak Following Microvascular Decompression: the Benefit …Cancelado
NCT01598961 · Determination of Target of Adequate Partial Neuromuscular Bl…Concluído
NA
NCT01613781 · Determination of Target of Adequate Partial Neuromuscular Bl…Concluído
NA
NCT01728428 · A Multicenter, Observational Study to Evaluate Clinical Mani…Concluído
NCT01726725 · Hemifacial Spasm and DesfluraneUNKNOWN
NCT01564979 · Effect on Tear Functions of Pretarsal and Preseptal Techniqu…UNKNOWN
PHASE2
NCT01546805 · Testing the Effect of Zinc Supplementation to Improve the Tr…UNKNOWN
NA
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
1.187 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 1.187

#1

Improved quality of life after microvascular decompression for hemifacial spasm.

Brain &amp; spine2026

This study aimed to evaluate the effectiveness of microvascular decompression (MVD) in improving the quality of life (QoL) of patients with hemifacial spasm (HFS), focusing on both short- and long-term outcomes. When will patients with HFS benefit from MVD regarding QoL? A longitudinal, prospective cohort study was conducted, involving 135 patients who underwent MVD at a tertiary referral center between January 2019 and March 2023. Health-related quality of life (HR-QoL) was assessed using the SF-36 questionnaire administered at three intervals: before surgery, three months after surgery, and twelve months after surgery. Most patients reported complete resolution (63.4%) or at least 90% reduction (13.9%) of spasms after twelve months. Significant improvements were observed in the SF-36 scores, particularly in the domains of Mental Health and Social Functioning, from baseline to twelve months after surgery. Additionally, improvements in Mental Component Summary scores were statistically significant, suggesting substantial importance of patient-reported mental and emotional well-being. Permanent postoperative complications (hearing reduction/loss, mild hoarseness) were seen in 2.9%. The findings confirm that MVD provides significant and sustained improvements in HR-QoL in patients with HFS. The surgery not only alleviates physical symptoms but also contributes to substantial psychosocial recovery. These outcomes support MVD as a preferred treatment for HFS when a neurovascular conflict is suspected, advocating for its broader application in clinical practice. Continued follow-up and research are recommended to further document the procedure's long-term effectiveness and safety.

#2

Geometric Microstructural Characteristics of White Matter Differentiate Patients With Facial Dyskinesias and Palsy.

CNS neuroscience &amp; therapeutics2026 Feb

The heterogeneous and homogeneous clinical manifestations of peripheral facial palsy (FP), hemifacial spasm (HFS), and Meige's syndrome (MS) complicate the differentiation of diagnoses for these facial motor diseases. To comprehensively investigate the white matter microstructural characteristics in patients with facial dyskinesias and palsy using geometric and integrity metrics in DTI. In this prospective study conducted from September 2020 to January 2022, patients with FP, HFS, and MS, as well as sex-matched healthy control subjects, underwent 3.0 T MRI. Geometric metrics (i.e., splay, bend, twist, and total distortion) based on "Director Field Analysis" and fractional anisotropy (FA) and mean diffusivity (MD) were calculated from DTI data. Cross-sectional tract-based spatial statistics were performed among FP, HFS, MS patients, and healthy controls. The correlation between disease severity and DTI metrics was evaluated. Additionally, the geometric microstructural properties combining FA and MD were used to classify FP, HFS, and MS patients using machine learning methods. Geometric metrics and FA/MD were widely altered across white matter in FP and HFS patients compared with healthy controls. However, in MS patients only DFA metrics were significantly altered. FA and DFA values strongly correlated with the severity of facial movement disorder in FP patients. Combing conventional FA/MD value with DFA metrics enabled the diagnostic differentiation of FP and HFS from MS. Our findings demonstrated that the geometric microstructural information of white matter fibers could provide novel insight into the underlying pathological changes in facial dyskinesias and palsy.

#3

Closed-loop wearable neurostimulation system with triboelectric sensing to alleviate hemifacial spasms.

Nature communications2026 Jan 10

Hemifacial spasm (HFS) is a neurological disorder characterized by involuntary contractions of the facial muscles, which can significantly influence patients' quality of life. Traditional diagnostic methods are often subjective, and electromyography (EMG) monitoring is constrained by equipment limitations and interference. Current treatments include short-term Botulinum toxin (BTX) injections and high-risk microvascular decompression (MVD), both of which suffer from low patient compliance. This study introduces a closed-loop facial nerve stimulation system integrated into eyewear, featuring triboelectric sensors doped with butylated melamine formaldehyde (BMF)-CaCu3Ti4O12 (CCTO), and constructed with micrometer-scale hemispherical structures, which enhance performance by approximately 2.3 times. These sensors capture subtle dynamic signal changes in real-time, suitable for monitoring minute facial muscle activities, while consuming zero power. Additionally, a customized electrical stimulation module with adjustable parameters and a high-precision HFS detection model have been developed, enabling rapid activation of facial nerve stimulators for targeted neuromodulation upon detecting spasms. The system achieves a recognition accuracy of 98% for HFS. Preliminary clinical validation demonstrates effectiveness in reducing spasm severity with inter-patient variability in two involved patients. Overall, this integrated system offers enhanced convenience and patient compliance, presenting a promising solution for HFS treatment.

#4

Evaluating the efficacy of botulinum toxin type a in alleviating neuropsychological symptoms in hemifacial spasm patients.

Neurological research2026 Mar 24

To evaluate the efficacy of botulinum toxin type A (BTX-A) in the treatment of neuropsychological symptoms in patients with hemifacial spasm (HFS). Sixty-three HFS patients with neuropsychological symptoms were randomly assigned in a 1:1 ratio to the BTX-A group (n = 32) and the citalopram hydrobromide (CH) group (n = 31). The BTX-A group was treated with facial injections, while the CH group received oral administration of 20 mg/day. Cornell Medical Index (CMI) scores were assessed before treatment and at 8 weeks after treatment. After 8 weeks, the BTX-A group exhibited significant reductions in total CMI scores and scores of the somatization, tension, anxiety, depression, and sensitivity subscales (p < 0.05). The CH group showed significant improvements in total CMI and scores of the somatization, anxiety, depression, sensitivity, anger, and tension subscales (p < 0.05). No significant differences between the two groups were observed in total CMI scores or scores of each CMI subscale (p > 0.05). The overall response rates were 63.3% in the BTX-A group and 70.0% in the CH group, with no significant difference between the two groups (p > 0.05). BTX-A improves both motor symptoms and short-term neuropsychological symptoms in patients with HFS.

#5

Historical evolution of microvascular decompression after Jannetta's establishment: Anatomical maps and physiological compasses-a narrative review.

Acta neurochirurgica2026 Mar 17

Building on the pioneering observations of Dandy and Gardner and on Jannetta's establishment of microvascular decompression (MVD) through microsurgical demonstration of vascular compression, MVD has continuously evolved into a safe and durable treatment for neurovascular compression syndromes. Despite advances in radiosurgery and pharmacotherapy, MVD remains widely used as a first-line surgical option for appropriately selected patients with trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia. This selective narrative historical review traces MVD's modern evolution after its establishment by Jannetta, organized into four pillars: surgical anatomy, optimization of approaches, decompression strategies, and operative support. Detailed microsurgical anatomy, including the "Rule of Three" framework for the cerebellopontine angle, has helped guide tailored, minimally invasive approaches (e.g., the lateral supracerebellar-infratentorial route for trigeminal neuralgia and infrafloccular exposure for hemifacial spasm). Decompression strategies have extended from prosthetic interposition toward noncompressive transposition and biologically harmonious fixation. Advances in visualization (endoscopic and exoscopic systems), simulation, and neuronavigation have extended the original visualization ethos and enhanced surgical education. Intraoperative monitoring, including brainstem auditory evoked potentials and lateral spread responses, has improved both complication avoidance and intraoperative confidence. Together, these anatomical "maps" and physiological "compasses" help define contemporary MVD practice aimed at safe and durable outcomes across diverse patient anatomies.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.809 artigos no totalmostrando 194

2026

Evaluating the efficacy of botulinum toxin type a in alleviating neuropsychological symptoms in hemifacial spasm patients.

Neurological research
2026

Historical evolution of microvascular decompression after Jannetta's establishment: Anatomical maps and physiological compasses-a narrative review.

Acta neurochirurgica
2026

Correlation between Delayed Relief after Microvascular Decompression and Morphology of the Lateral Spread Response in Patients with Hemifacial Spasm-Temporal versus Mandibular Branch Stimulation.

Neurologia medico-chirurgica
2026

Reconsidering the Pathophysiological Interpretation of Polyphasic LSRs in Hemifacial Spasm.

Neurologia medico-chirurgica
2026

Functional Assessment of Hemifacial Spasm Using a Whole-Face Surface Electromyography Electrode Array.

IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society
2026

Microvascular decompression for hemifacial spasm associated with large fenestration of the vertebral artery: illustrative case.

Journal of neurosurgery. Case lessons
2026

The Hidden Burden of Hemifacial Spasm: A Systematic Review of Non-Motor Symptoms.

Movement disorders clinical practice
2026

Improved quality of life after microvascular decompression for hemifacial spasm.

Brain &amp; spine
2026

Beyond Improvement of Motor Symptoms: Central Effects of Botulinum Toxin on Anxiety and Depression in Focal Dystonia, Hemifacial Spasm, and Blepharospasm.

Toxins
2026

Keyhole retrosigmoid approach for microvascular decompression surgery: systematic review and single-arm meta-analysis.

Neurosurgical review
2026

Real-World Retrospective Safety Analysis of OnabotulinumtoxinA for the Treatment of Patients with Chronic Migraine and Concomitant Therapeutic Indications.

Pain and therapy
2026

Electroacupuncture for chemotherapy-induced hemifacial spasm: a case report.

Frontiers in medicine
2026

[Posterior petrous meningiomas: clinical manifestations, anatomical relationships and postoperative outcomes].

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2025

The Role of Botulinum Toxin in Dry Eye Disease and Meibomian Gland Dysfunction Associated with Hemifacial Spasm.

Beyoglu eye journal
2026

Double-faced microprobe for vessel transposition in microvascular decompression: technical note.

Acta neurochirurgica
2026

Pivotal Factors for Minimizing the Risks of Therapeutic Failure in Trigeminal Neuralgia and Hemifacial Spasm.

Current pain and headache reports
2026

Recurrent Factors and Reoperation Strategies in Microvascular Decompression for Hemifacial Spasm.

The Journal of craniofacial surgery
2026

Predictors of Postoperative Complications After Microvascular Decompression for Trigeminal Neuralgia and Hemifacial Spasm: A Retrospective Cohort Study.

The Journal of craniofacial surgery
2026

Geometric Microstructural Characteristics of White Matter Differentiate Patients With Facial Dyskinesias and Palsy.

CNS neuroscience &amp; therapeutics
2026

Hemifacial Spasms with Unusual Neurovascular Compression Type: Arterial Cisternal Segment Offender.

Life (Basel, Switzerland)
2026

Bovine pericardial patch in an eggroll fashion and teflon felt microvascular decompression for trigeminal neuralgia and hemifacial spasm: A retrospective study.

Medicine
2026

Microvascular Decompression for Hemifacial Spasm without the Use of Neuromonitoring and Fix Retraction: A Single-Center Experience.

Turkish neurosurgery
2026

Experimental Study of a Newly Developed Prosthesis and Its Initial Clinical Use in Microvascular Decompression Surgery.

Neurologia medico-chirurgica
2026

Closed-loop wearable neurostimulation system with triboelectric sensing to alleviate hemifacial spasms.

Nature communications
2026

Efficacy and safety of microvascular decompression for hemifacial spasm: Endoscopy vs microscopy.

Medicine
2025

Knowledge, Attitudes, and Practices Toward Microvascular Decompression for Hemifacial Spasm Among Neurosurgeons: A Multicenter Cross-Sectional Study.

Journal of multidisciplinary healthcare
2025

Regional abnormalities in the hippocampus and verbal memory impairment in craniofacial dystonia.

Frontiers in neuroscience
2025

Hemodynamic Features of Offending Vessels in Primary Hemifacial Spasm: A Computational Fluid Dynamics Study.

Annals of biomedical engineering
2025

MRA morphologic study of the vertebrobasilar artery system in patients with primary hemifacial spasm.

Neuro endocrinology letters
2025

The other Babinski sign in Hemifacial Spasm: a clinical marker of severity and its predictive association with η-like vA-PICA compression.

Annals of medicine
2025

Bilateral Hemifacial Spasm with "Other Babinski Sign".

Annals of Indian Academy of Neurology
2025

Diabetic Striatopathy as a Presenting Symptom in Newly Diagnosed Type 2 Diabetes Mellitus: A Case Report.

Journal of the ASEAN Federation of Endocrine Societies
2026

Quantitative intraoperative lateral spread response amplitudes in hemifacial Spasm: Associations with vascular burden.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2025

Patient satisfaction and quality of life with hemifacial spasm treatments in Finland's largest hospital district.

Brain &amp; spine
2025

Disappearance of Lateral Spread Response: Reliability as a Prognostic Marker in Hemifacial Spasm.

Asian journal of neurosurgery
2025

How i do it: endoscopic transposition technique for hemifacial spasm caused by AICA compression.

Acta neurochirurgica
2025

Impact of Ultrasound-guided Superficial Cervical Plexus Block on Early Postoperative Recovery in Patients Undergoing Microvascular Decompression: A Randomized Controlled Trial.

Journal of neurosurgical anesthesiology
2025

[Familial hemifacial spasm].

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
2025

The application value of intraoperative lateral spreading response monitoring during microvascular decompression in patients with primary hemifacial spasm.

European journal of medical research
2025

Preoperative sleep disturbance as a risk factor for moderate-to-severe postoperative pain in hemifacial spasm patients: a prospective cohort study.

Frontiers in neurology
2025

Impact of Preoperative Botulinum Toxin Injections on Postoperative Outcomes After Redo Microvascular Decompression for Hemifacial Spasm.

Neurosurgery
2025

Radiation-induced cavernous malformation within a vestibular schwannoma: A case report.

SAGE open medical case reports
2025

Microvascular decompression for neurovascular compression syndromes secondary to vertebrobasilar dolichoectasia: a single-center retrospective analysis.

Frontiers in surgery
2025

Microvascular Decompression in a Patient With Positional Hemifacial Spasm: Case Report.

Neurosurgery practice
2026

Patient-Perceived Response to Medical Treatment for Hemifacial Spasm.

Journal of movement disorders
2025

Evaluating the diagnostic role of magnetic resonance imaging in trigeminal neuralgia, hemifacial spasm, and glossopharyngeal neuralgia: A controlled blinded study.

Brain &amp; spine
2025

A clinical nomogram for predicting recurrence after percutaneous radiofrequency ablation in the management of primary hemifacial spasm.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2025

Outcomes of Microvascular Decompression for Hemifacial Spasm at the Philippine General Hospital.

Acta medica Philippina
2025

Hemifacial spasms caused by compression of the labyrinthine artery on the facial nerve in the internal auditory canal: a case report and review of the literature.

Journal of medical case reports
2025

Factors Affecting Surgical Complexity of Microvascular Decompression for Hemifacial Spasm.

Neurologia medico-chirurgica
2025

A bony landmark in craniotomy for hemifacial spasm: The inferior retrosigmoid eminence.

Neurosurgical review
2025

Comparison of Prognosis After Microvascular Decompression in Combined and Single Hyperactive Dysfunction Syndrome of the Cranial Nerves.

World neurosurgery
2025

Botulinum toxin therapy for neurological disorders: Serendipitous benefits on sleep quality and underlying mechanisms.

Sleep medicine reviews
2025

Hemifacial spasm in the Middle East: Insights from a high-volume tertiary care center.

Clinical neurology and neurosurgery
2025

How I do it: sling transposition technique with biopatch and aneurysm clip for hemifacial spasm.

Acta neurochirurgica
2025

Compression-specific treatment strategies for vertebroarterial-involved hemifacial spasm: A single-centre retrospective analysis of surgical techniques.

Neurosurgical review
2025

How I do it: simultaneous microvascular decompression for dolichoectatic vertebrobasilar artery-associated trigeminal neuralgia and hemifacial spasm.

Acta neurochirurgica
2025

Periocular clinical differences between primary and postparalytic hemifacial spasm: A retrospective comparative study.

Indian journal of ophthalmology
2025

Fully Endoscopic Microvascular Decompression for Hemifacial Spasm Using 2-Dimensional/3-Dimensional Endoscopy: Clinical Analysis of 204 Cases.

Operative neurosurgery (Hagerstown, Md.)
2025

Autologous Fibrin Glue in Microvascular Decompression for Trigeminal Neuralgia and Hemifacial Spasm.

Neurologia medico-chirurgica
2025

A Successful Treatment of Hemifacial Spasm After Flow Diverter Stent Placement for Ipsilateral Internal Carotid Artery Saccular Aneurysm.

Journal of medical cases
2026

Investigating the correlation between the blepharospasm disability index and botulinum neurotoxin dosage for benign essential blepharospasm and hemifacial spasm.

Orbit (Amsterdam, Netherlands)
2025

Trigeminal neuralgia or hemifacial spasm due to vertebrobasilar dolichoectasia: a single-center case series and systematic review.

Neurosurgical focus
2025

Muscle pad interposition technique in microvascular decompression for primary hemifacial spasm: a single-center case series and systematic review.

Neurosurgical focus
2025

Microvascular decompression for hemifacial spasm involving a tortuous vertebral artery: a single-center 100-patient series with surgical nuances and literature review.

Neurosurgical focus
2025

The impact of perforating arterial branches on microvascular decompression for hemifacial spasm.

Neurosurgical focus
2025

Factors associated with persistent abnormal muscle responses in microvascular decompression for hemifacial spasm and prognostic analysis.

Neurosurgical focus
2025

Is complete elimination of lateral spreading response essential in microvascular decompression for hemifacial spasm?

Neurosurgical focus
2025

Timing matters: evaluating lateral spreads response disappearance as a prognostic marker in microvascular decompression for hemifacial spasm: a phenomenological study.

Acta neurochirurgica
2025

Electrophysiological Evidence of Contralateral Neuromuscular Effects Following Long-Term Botulinum Toxin Therapy in Hemifacial Spasm.

Toxins
2026

Revolutionizing Patient Education: Artificial Intelligence Versus Experts in Ocular Dyskinesia Responses.

Ophthalmic plastic and reconstructive surgery
2025

Hemifacial Spasm and Blepharospasm: Divergent Social Cognition Performance Despite Similar Neurocognitive Profiles.

Brain and behavior
2025

The efficacy of augmented reality technology assisted by 3D-CT reconstruction in microvascular decompression for hemifacial spasm craniotomy.

BMC surgery
2025

Large posterior fossa meningioma presenting with hemifacial spasm.

Surgical neurology international
2025

The glabella tap reflex reveals fluctuations in the hyperexcitability of the facial nucleus with hemifacial spasm: a prospective observational study.

Neurosurgical review
2025

Beyond the needle: how clinician expertise affects outcomes in the treatment of hemifacial spasm.

Clinical parkinsonism &amp; related disorders
2025

Exploring Facial Nucleus-Centered Connectivity in Hemifacial Spasm: Novel Insights into Pathogenesis and Surgical Impact.

Brain topography
2025

Cervical vestibular evoked myogenic potentials are not disturbed in hemifacial spasm and blepharospasm.

Acta neurologica Belgica
2025

Prediction of treatment failure and early identification of tumor progression after Gamma-Knife radiosurgery in vestibular schwannoma: A retrospective cohort study.

Neuro-oncology advances
2025

Current state of intraoperative neuromonitoring of the facial nerve during skull base surgery: A systematic review.

Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia
2025

[Surgical treatment of otogenic pain and auditory symptoms in a patient with hemifacial spasms].

Ugeskrift for laeger
2025

Efficacy of isolated periocular botulinum toxin A injections versus periocular and adjunctive lower facial injections in hemifacial spasm: a randomized, controlled, noninferiority, crossover trial.

Annals of medicine
2025

Uses of Botulinum Toxin in Headache and Facial Pain Disorders: An Update.

Toxins
2025

Impact of flocculus medial extension on the root exit zone visibility during microvascular decompression for hemifacial spasm.

Neurosurgical review
2025

A Proposal for Standardized Analysis of Microvascular Decompression Results in Hemifacial Spasm.

World neurosurgery
2025

Hemifacial spasm: an update on pathophysiology, investigations and management.

Journal of neurology
2025

Monitoring of the lateral spread response combined with brainstem auditory evoked potentials in microvascular decompression for hemifacial spasm.

Frontiers in neurology
2025

Spontaneous Resolution of Hemifacial Spasm Following Falcotentorial Meningioma Resection: Impact of Posterior Cranial Fossa Volume Changes on Hemifacial Spasm.

Cureus
2025

A retrospective study of the effect of papaverine on perioperative efficacy of microvascular decompression in the treatment of hemifacial spasm.

Clinical neurology and neurosurgery
2025

Minimal important changes of HFS-30 and HFS-7 questionnaires for patients with hemifacial spasm.

Clinical parkinsonism &amp; related disorders
2025

Non-Root Exit Zone Exploration during Facial Nerve Microvascular Decompression: A Discussion of the Pathogenesis in Atypical Cases of Hemifacial Spasm.

Turkish neurosurgery
2025

Postoperative Dysphagia Management in Hemifacial Spasm: A Case Report of Combined Catheter Balloon and Neuromuscular Stimulation.

The American journal of case reports
2025

Fully endoscopic microvascular decompression for painful tic convulsif secondary to vertebrobasilar dolichoectasia.

American journal of translational research
2025

Botulinum toxin type A injections demonstrate remarkable efficacy in treating hemifacial spasm in elderly patients.

American journal of translational research
2025

Intraoperative use of lateral spread response measurement in the upper orbicularis oculi and mandibular muscles in patients with hemifacial spasm after botulinum toxin treatment.

Acta neurochirurgica
2026

Bilateral Hemifacial Spasm After Filler Injection.

Ophthalmic plastic and reconstructive surgery
2025

Glue-transposition technique for hemifacial spasm involving vertebrobasilar dolichoectasia: a comparative study and literature review.

Neurosurgical review
2025

Risk Factors for Delayed Facial Palsy Following Microvascular Decompression in Hemifacial Spasm: A Systematic Review and Meta-Analysis.

World neurosurgery
2025

Twists of trouble: AICA loops as the culprit in hemifacial spasm.

Radiology case reports
2025

Can blepharospasm and hemifacial spasm spontaneously resolve? A long-term review of facial spasm patients from two large medical centers.

European journal of ophthalmology
2026

Simple Microvascular Decompression for Hemifacial Spasm Caused by Dolichoectatic Vertebral Artery.

Operative neurosurgery (Hagerstown, Md.)
2025

Identifying associated comorbidities in the development of trigeminal neuralgia: A propensity-matched analysis of the National Inpatient Sample.

Clinical neurology and neurosurgery
2025

Neurovascular Conflict on Asymptomatic Sides of Hemifacial Spasm Using Magnetic Resonance Imaging Three-Dimensional Volumetric Interpolated Breath-Hold Examination Sequence: A Retrospective Study.

World neurosurgery
2025

Botulinum Toxin Injection for Hemifacial Spasm and Benign Essential Blepharospasm: A Systematic Review and Meta-Analysis Comparing Pretarsal and Preseptal Injection Techniques.

Aesthetic plastic surgery
2025

Lateral Spread Response in Hemifacial Spasm: Physiological Mechanisms, Intraoperative Utility, and Prognostic Significance.

Cureus
2025

Botulinum Toxin Type A Injection Near the Stylomastoid Foramen: A Safe and Effective Therapeutic Modality for Tinnitus in Patients With Hemifacial Spasm.

Otology &amp; neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology
2025

Risk factors and Occurrence of Small vessel disease in Acute sensorineural hearing Loss In the Elderly: protocol for a multicentre cross-sectional study.

BMJ open
2025

Which surgical technique has a superior clinical outcome in microvascular decompression? a systematic review and meta-analysis study of transposition versus interposition for trigeminal neuralgia and hemifacial spasm.

Neurosurgical review
2025

The silent scream: Unraveling vagal nerve neuralgia; VANCOUVER syndrome and HeLPS.

Clinical neurology and neurosurgery
2025

Letter: Evaluation of 2 Surgical Techniques-Transposition Versus Interposition Microvascular Decompression for Hemifacial Spasm: A Systematic Review of 19 437 Patients.

Neurosurgery
2026

A Comparative Study of Traditional and Synchronous Video Lateral Spread Response Monitoring in Predicting Long-Term Hemifacial Spasm Relief After Microvascular Decompression Surgery.

Operative neurosurgery (Hagerstown, Md.)
2025

Multicentric comparative study of botulinum toxin treatment in patients with hemifacial spasm.

European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
2025

A 12-Week Prospective, Double-Blind, Multicenter, Randomized Study Comparing 100 Units of Abobotulinum Toxin Type A (Dysport®) and 33.33 Units of Neubotulinum Toxin Type A (Neuronox®) for the Treatment of Hemifacial Spasm.

Toxins
2025

Fully Endoscopic Microvascular Decompression for Neurovascular Compression Syndrome: Early Outcomes and Technical Note.

World neurosurgery
2025

A New Form of Combined Hyperactive Dysfunction Syndrome: A Unique Case.

Cureus
2025

Arterial Hypertension After Macrovascular Decompression of Vertebrobasilar Dolichoectasia: Rethinking the Cause-Effect Relationship.

World neurosurgery
2025

Ephatic transmission impairs trigemino-cervical reflex monitoring during microvascular decompression surgery for hemifacial spasm.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
2025

Personality traits and their effects in patients with hemifacial spasm.

Scientific reports
2025

Impact of offending vessel location on lateral spread response variations in hemifacial spasm patients.

Frontiers in neurology
2025

Comparison of Surgical Outcomes in Microscopic and Fully Endoscopic Microvascular Decompression for Hemifacial Spasm.

Neurologia medico-chirurgica
2025

Teaching Video NeuroImage: Bilateral Hemifacial Spasm and Left Glossopharyngeal Neuralgia Caused by Bilateral Vertebral Artery Displacement.

Neurology
2025

Morbid Obesity and Diabetes Increase the Risk of Reoperation following Microvascular Decompression: A National Surgical Quality Improvement Program Analysis of 1,303 Patients.

Journal of neurological surgery. Part B, Skull base
2025

Evaluating YouTube as a source of information on hemifacial spasm.

Clinical parkinsonism &amp; related disorders
2025

How I do it: combined interposition-transposition technique for microvascular decompression in primary hemifacial spasm.

Acta neurochirurgica
2025

Laser ablation of a fourth ventricular hamartoma causing medically refractory hemifacial spasms in a child: illustrative case.

Journal of neurosurgery. Case lessons
2025

Experience of the application of botulinum toxin type A as a treatment of facial hyperkinetic disorders in a Mexican ophthalmological center.

Archivos de la Sociedad Espanola de Oftalmologia
2025

Fully endoscopic microvascular decompression for hemifacial spasm: a systematic review.

Neurosurgical review
2025

Hemifacial Spasm Caused by Posterior Inferior Cerebellar Artery Compression due to Vertebral Artery Aneurysm: Management with Stent-Assisted Coil Embolization.

Neurointervention
2025

Patient Burden in Dystonia Diagnosis and Botulinum Toxin Treatment: A Nationwide Survey in Turkey.

Brain and behavior
2025

Assessment of quality of life in patients with cervical dystonia and hemifacial spasm after botulinum toxin injections.

Acta neurologica Belgica
2024

Comments to "Radiofrequency Thermocoagulation as a Treatment for Hemifacial Spasm: Long-term Follow-up and Management of Recurrences".

Acta neurochirurgica
2025

Analysis of Endoscope-Assisted Retrosigmoid Approach versus Modified Transjugular Approach for Microvascular Decompression of the Facial Nerve: A Comparative Cadaveric Study.

World neurosurgery
2025

Impact of Proposed Medicare Policy Changes for Botulinum Toxin Coverage on Hemifacial Spasm and Facial Dystonia.

Facial plastic surgery &amp; aesthetic medicine
2025

Human-in-the-loop machine learning-based quantitative assessment of hemifacial spasm based on volumetric interpolated breath-hold examination MR.

The British journal of radiology
2025

Preventive Effects of Botulinum Neurotoxin Long-Term Therapy: Comparison of the 'Experienced' Benefits and 'Suspected' Worsening Across Disease Entities.

Journal of clinical medicine
2025

Role of stereotactic radiosurgery for intracranial epidermoid tumors: a systematic review to assess its safety, efficacy, and complication profile.

Journal of neuro-oncology
2025

Dosage of botulinum toxin in patients undergoing treatment for hemifacial spasm: is there modification during follow-up?

Arquivos de neuro-psiquiatria
2025

Microvascular decompression: a contemporary update.

BMC surgery
2025

Increasing Incidence of Facial Nerve Disorders in the United States from 2007 to 2022.

The Laryngoscope
2025

Primary Gamma Knife Radiosurgery as a Treatment Option for Hamartoma of Floor of Fourth Ventricle: A Case Report of Pediatric Hemifacial Spasm.

Pediatric neurosurgery
2025

From spasms to smiles: how facial recognition and tracking can quantify hemifacial spasm severity and predict treatment outcomes.

Acta neurochirurgica
2024

A Case of Hemifacial Spasm Caused by Penetration of the Anterior Inferior Cerebellar Artery between the Facial Nerve and the Nervus Intermedius.

NMC case report journal
2025

Application of neurophysiological monitoring in differentiation of hemifacial spasm and post-facial paralysis synkinesis.

Neurophysiologie clinique = Clinical neurophysiology
2025

Botulinum toxin modulates the blink reflex via the trigeminal afferent system in hemifacial spasm: an early and late-term effect.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2025

Diagnostic Utility of Clinical Neurophysiology in Jerky Movement Disorders: A Review from the MDS Clinical Neurophysiology Study Group.

Movement disorders clinical practice
2024

Bibliometric analysis of research developments in oral and maxillofacial neuralgia from 2004 to 2023.

Medicine
2024

[Microvascular decompression in hemifacial spasm: functional outcome].

Medicina
2024

Treatment Challenges in Hemifacial Spasm: The Role of Magnetic Resonance Imaging.

World journal of plastic surgery
2025

Isolated Hemifacial Spasm as the Presenting Sign of Cerebral Glioblastoma.

Ophthalmic plastic and reconstructive surgery
2024

Dynamic changes of abnormal muscle response during decompression procedures in double compression-type hemifacial spasm.

Surgical neurology international
2025

The effect of botulinum neurotoxin A injections on meibomian glands and dry eye.

The ocular surface
2024

Robot-assisted stylomastoid foramen puncture and radiofrequency ablation for hemifacial spasm treatment: clinical outcomes and technique assessment.

Neurosurgical focus
2024

Evaluation of 2 Surgical Techniques-Transposition Versus Interposition Microvascular Decompression for Hemifacial Spasm: A Systematic Review of 19 437 Patients.

Neurosurgery
2025

Revision Surgery of Microvascular Decompression for Hemifacial Spasm: 2-Dimensional Operative Video.

World neurosurgery
2025

A New Management Strategy for Hemimasticatory Spasm.

Journal of neurological surgery. Part A, Central European neurosurgery
2024

Abnormal electromyographical trigeminal activation through stimulation of the offending artery (Z-L response): An intraoperative tool during microvascular decompression for trigeminal neuralgia.

Cephalalgia : an international journal of headache
2024

Efficacy and safety of botulinum neurotoxin in the treatment of hemifacial spasms: a systematic review and meta-analysis.

BMC neurology
2024

The progress in epidemiological, diagnosis and treatment of primary hemifacial spasm.

Heliyon
2025

Primary hemifacial spasm: anatomical insights.

Acta neurologica Belgica
2024

Efficacy and safety of reoperation for residual or recurrent hemifacial spasm after microvascular decompression: a systematic review and meta-analysis.

Neurosurgical review
2025

Obliteration of the Superior Petrosal Vein During Cerebellopontine Angle-Surgery: More Cons than Pros?

World neurosurgery
2025

Determining prognostic factors in the treatment of primary hemifacial spasm: Clinical outcomes and complications. A literature review.

World neurosurgery: X
2024

A novel 3D multimodal fusion imaging surgical guidance in microvascular decompression for primary trigeminal neuralgia and hemifacial spasm.

Head &amp; face medicine
2024

Optimizing surgical technique in microvascular decompression for hemifacial spasm - Results from a surgical series with contemporary use of neuronavigation and intraoperative neuromonitoring.

Surgical neurology international
2025

Clinical analysis of abnormal muscle response monitoring for hemifacial spasm during microvascular decompression: a retrospective study.

Acta neurologica Belgica
2024

Altered Brain Structure in Hemifacial Spasm Patients: A Multimodal Brain Structure Study.

International journal of general medicine
2024

Impact of microvascular decompression on wall shear stress in responsible arteries in trigeminal neuralgia and hemifacial spasm.

Scientific reports
2025

Enhancing surgical precision: a novel electromyography finding for confident identification of the root exit zone during microvascular decompression surgery.

Journal of neurosurgery
2024

Optimized microvascular decompression surgery for improving the results of hemifacial spasm: an analysis of reoperations.

Neurosurgical review
2024

Hemifacial spasms triggered by compression of tortuous anterior inferior cerebellar artery loop on the facial nerve in the internal auditory canal: A case report.

Medicine
2023

Clinical Profile of Patients with Hemifacial Spasm at a Tertiary Eye Care Center in South India: A Retrospective Study.

Journal of current ophthalmology
2024

The value of multimodal imaging fusion in preoperative visualization assessment of neurovascular relationship in hemifacial spasm: a single-center retrospective study.

Neurosurgical review
2024

Comparative study of CTA/CTV and MRTA for preoperative simulation of microvascular decompression in neurovascular compression syndromes.

Neurosurgical review
2024

Evaluating Headache Incidence and Characteristics After Botulinum Toxin Treatment in Blepharospasm and Hemifacial Spasm Patients: A Retrospective Cohort Clinical Study.

Clinical neuropharmacology
2024

Correlation between Delayed Relief after Microvascular Decompression and Morphology of the Lateral Spread Response in Patients with Hemifacial Spasm-Further Examination with Compound Motor Action Potentials.

Neurologia medico-chirurgica
2024

Neurovascular conflict in primary hemifacial spasm: A radiological topographic and severity assessment of contact.

Parkinsonism &amp; related disorders
2024

Evaluation of the effect of botulinum toxin A on the physical and mental health of patients with hemifacial spasm.

Neurologia
2024

Does blepharospasm effect biometric parameters and intraocular lens power calculations?

International ophthalmology
2024

CT-guided facial nerve radiofrequency treatment via unilateral stylomastoid Foramen only relieve unilateral facial expressive muscle spasms in Meige's syndrome.

Asian journal of surgery
2024

Patient Characteristics and Real-World Use of Botulinum Toxins for the Treatment of Cervical Dystonia, Blepharospasm, and Hemifacial Spasm.

Toxins
2024

Defining the clinical phenomenology of Hemifacial Spasm as the presenting feature of idiopathic intracranial hypertension: case report and literature review.

Acta neurologica Belgica
2024

Predictive nomogram for hearing deficits after microvascular decompression treatment.

Neurosurgical review
2024

Body image and social anxiety in hemifacial spasm: Examining self-esteem and fear of negative evaluation as mediators.

Clinical neurology and neurosurgery
2024

Application of the semidiving technique in fully endoscopic microvascular decompression.

Neurosurgical review
2025

Botulinum toxin treatment for hemifacial spasm: harmonising neurological and aesthetic outcomes.

Journal of neural transmission (Vienna, Austria : 1996)
2024

Posterior petrous meningioma with secondary trigeminal neuralgia: microsurgical resection after stereotactic radiosurgery (case report and literature review).

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko
2024

Phenomenological patterns and aetiological spectrum in patients visiting a tertiary care Movement disorders service in India: An observational study.

Clinical neurology and neurosurgery
2024

Effectiveness of 0.3% Hyaluronic Acid Eye Drops for Benign Essential Blepharospasm and Hemifacial Spasm with Botulinum Toxin-induced Dry Eye.

Plastic and reconstructive surgery. Global open
2024

Assessment of prevalence of vascular contact of the facial nerve in asymptomatic patients using three-dimensional constructive interference in steady-state (3D CISS) MRI acquisition.

Polish journal of radiology
2024

Asymptomatic Purely Intracranial Vagal Schwannoma: Clinical Case Report and Literature Review.

Turkish neurosurgery
2025

Hemifacial spasm associated with trigeminal neuralgia secondary to trigeminal vascular compression.

Neurocirugia
2024

Intralesional epileptiform activity in a fourth ventricular hamartoma associated with epileptic hemifacial spasm in a toddler: illustrative case.

Journal of neurosurgery. Case lessons
2024

Association of Coronavirus Disease 2019 Vaccination with Facial-Related Neurological Disorders: A Nationwide Retrospective Cohort Study.

Journal of personalized medicine
2025

Objective assessment of tear film in blepharospasm, facial hemispam and aberrant regeneration with periocular botulinum toxin-A.

European journal of ophthalmology
Ver todos os 1.809 no EuropePMC

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Improved quality of life after microvascular decompression for hemifacial spasm.
    Brain &amp; spine· 2026· PMID 41782998mais citado
  2. Geometric Microstructural Characteristics of White Matter Differentiate Patients With Facial Dyskinesias and Palsy.
    CNS neuroscience &amp; therapeutics· 2026· PMID 41603069mais citado
  3. Closed-loop wearable neurostimulation system with triboelectric sensing to alleviate hemifacial spasms.
    Nature communications· 2026· PMID 41519956mais citado
  4. Evaluating the efficacy of botulinum toxin type a in alleviating neuropsychological symptoms in hemifacial spasm patients.
    Neurological research· 2026· PMID 41875217mais citado
  5. Historical evolution of microvascular decompression after Jannetta's establishment: Anatomical maps and physiological compasses-a narrative review.
    Acta neurochirurgica· 2026· PMID 41844954mais citado
  6. Neurogenic irritable bowel syndrome? Long-term resolution of chronic gastrointestinal stress following vagus nerve microvascular decompression: illustrative case.
    J Neurosurg Case Lessons· 2026· PMID 41974052recente
  7. Factors associated with recurrence after microvascular decompression for hemifacial spasm: A comprehensive analysis stratified by postoperative recovery patterns.
    Clin Neurol Neurosurg· 2026· PMID 41955681recente
  8. Endoscopic microvascular decompression for hemifacial spasm associated with an enlarged jugular tubercle: A case report.
    Surg Neurol Int· 2026· PMID 41952742recente
  9. Psychological and motor outcomes of botulinum toxin in hemifacial spasm and blepharospasm.
    Int Ophthalmol· 2026· PMID 41934473recente
  10. [Surgical treatment of hemifacial spasm: a systematic review].
    Zh Vopr Neirokhir Im N N Burdenko· 2026· PMID 41930436recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:221083(Orphanet)
  2. OMIM OMIM:141405(OMIM)
  3. MONDO:0007713(MONDO)
  4. GARD:17137(GARD (NIH))
  5. Busca completa no PubMed(PubMed)
  6. Q55780912(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Espasmo hemifacial clônico
Compêndio · Raras BR

Espasmo hemifacial clônico

ORPHA:221083 · MONDO:0007713
Prevalência
1-5 / 10 000
CID-10
G51.3 · Espasmo hemifacial clônico
CID-11
Ensaios
3 ativos
Início
Adult, Elderly
Prevalência
10.95 (Worldwide)
MedGen
UMLS
C1841639
EuropePMC
Wikidata
Papers 10a
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