Pular para o conteúdo
Esquistossomose
ORPHA:1247CID-10 · B65.0CID-11 · 1F86ENDÊMICA NO BRASIL
Esta condição está no Orphanet, mas não é rara no Brasil. Endêmica BR — ~25M expostos (MS); notificação compulsória. Fonte: PRC4-2017.
Esta doença tem causa genética. Recomendamos procurar um médico geneticista para diagnóstico, exames genéticos e aconselhamento familiar.
DigestivoInício todas idadesHerança Unknown
Também conhecida comoBilharzíaseEsquistossomíaseBilhárziaBilharziose

Doença infecciosa causada por trematódeos parasitas do gênero Schistosoma que colonizam os vasos sanguíneos humanos e liberam ovos que podem causar reações granulomatosas que levam a doenças agudas (coceira do nadador ou síndrome da esquistossomose aguda) ou crônicas. Dependendo de onde os ovos se alojam, as manifestações da esquistossomose crônica podem incluir diarreia, dor abdominal, perda de apetite, anemia (intestinos), hepatoesplenismo, fibrose periportal com hipertensão portal (fígado), inflamação e cicatrizes urogenitais, hematúria e disúria (aparelho geniturinário). Outros pacientes podem ser assintomáticos.

Última verificação: Fonte: sem afirmação sobre o SUS a verificarEm construçãohistóricoSugerir correção
Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

💬
EM LINGUAGEM SIMPLES

A Esquistossomose é uma infecção causada por parasitas que entram nos vasos sanguíneos e liberam ovos em diferentes órgãos do corpo. Ela pode provocar dor na barriga, diarreia, sangue nas fezes, urina com sangue ou inchaço no fígado e no baço. A CONITEC aprovou a ampliação do Praziquantel no SUS para crianças pequenas e ampliou a elastografia hepática para diagnosticar fibrose no fígado. Por outro lado, o medicamento Oxamniquina foi oficialmente excluído do SUS em 2025 para tratar a doença.

📋
Informacoes curadas por IA — podem conter imprecisoes

Doença infecciosa causada por trematódeos parasitas do gênero Schistosoma que colonizam os vasos sanguíneos humanos e liberam ovos que podem causar reações granulomatosas que levam a doenças agudas (coceira do nadador ou síndrome da esquistossomose aguda) ou crônicas. Dependendo de onde os ovos se alojam, as manifestações da esquistossomose crônica podem incluir diarreia, dor abdominal, perda de apetite, anemia (intestinos), hepatoesplenismo, fibrose periportal com hipertensão portal (fígado), inflamação e cicatrizes urogenitais, hematúria e disúria (aparelho geniturinário). Outros pacientes podem ser assintomáticos.

Pesquisas ativas
12 ensaios
94 total registrados no ClinicalTrials.gov
Publicações científicas
21.699 artigos
Último publicado: 2026 Mar
Medicamentos
2 com registro
FAR-MANGUINHOS PRAZIQUANTEL, PRAZIQUANTEL (PRAZIQUANTEL)

Tem tratamento?

✓ 2 medicamentos específicos desta doença (registro ANVISA, FDA ou SUS/CEAF)
Ver detalhes, fases e interações →
FAR-MANGUINHOS PRAZIQUANTELPRAZIQUANTEL (PRAZIQUANTEL)

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
<1 / 1 000 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Europe
Início
All ages
🏥
SUS: Cobertura mínimaScore: 0%
CID-10: B65.0
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🫃
Digestivo
1 sintomas
🩸
Sangue
1 sintomas
🫘
Rins
1 sintomas

+ 1 sintomas em outras categorias

Características mais comuns

—
Hepatoesplenomegalia
—
Eosinofilia
—
Hematoquezia
—
Hematúria
4sintomas
Sem dados (4)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 4 características clínicas mais associadas, ordenadas por frequência.

HepatoesplenomegaliaHepatosplenomegaly
EosinofiliaEosinophilia
HematoqueziaHematochezia
HematúriaHematuria

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico21.699PubMed
Últimos 10 anos200publicações
Pico2026167 papers
Linha do tempo
2026Hoje · 2026🧪 1998Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
✓Aprovado4
3Fase 313
2Fase 213
1Fase 17
·Pré-clínico57
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 94 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Esquistossomose

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Onde estão os ensaios

Com ensaio aberto em 18 países. O ponto verde marca onde há vaga agora.

🟢 Recrutando agora

6 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

94 ensaios clínicos encontrados, 12 ativos.

Distribuição por fase
NCT07453030 · Long-Term Outcomes of Selexipag in Schistosomiasis-Associate…Em breve
🇧🇷 Brasil
NCT07754617 · Different Treatment Frequencies for Hepatic Fibrosis Due to …Em breve
PHASE2, PHASE3Uganda
NCT07707193 · Assessment of Right Ventricular-Pulmonary Arterial Coupling …Em breve
NA🇪🇬 Egito
NCT07482215 · Prevalence and Molecular Identification of Human Schistosomi…Em breve
NCT07500740 · Nanobody-based Schistosomiasis Urine Test Kit ResearchEm breve
Tanzania
NCT06828536 · Female Genital Schistosomiasis in Migrant Women: A Pilot Stu…Em breve
NA
NCT03110757 · A Phase Ib Study of the Safety, Reactogenicity, and Immunoge…Concluído
PHASE1🇧🇷 Brasil
NCT01154049 · Study to Evaluate the Safety of the Vaccine Prepared sm14 Ag…Concluído
PHASE1🇧🇷 Brasil
NCT01931826 · Treatment Schistosomal Portal Hypertension: Efficacy of Endo…Concluído
NA🇧🇷 Brasil
NCT07507461 · Protocol for Integrating Mass Drug Administration Into Prima…Concluído
NAKenya
NCT06808750 · Performance of Tests for Schistosoma Haematobium DiagnosisConcluído
Tanzania
NCT06973200 · Burden of Schistosomiasis and Soil-transmitted Helminth Infe…Concluído
Burkina Faso
NCT06312462 · Health Education Model Led by Community Health Volunteers.Concluído
NATanzania
NCT05868005 · Delivering a Multi-disease Screening Tool to Migrant Populat…Concluído
NA🇪🇸 Espanha
NCT05762393 · A Study to Evaluate the Safety, Tolerability, and Immunogeni…Concluído
PHASE1Burkina Faso · Madagascar
NCT05292391 · Safety, Tolerability, and Immunogenicity Study of Sm-p80 + G…Concluído
PHASE1🇺🇸 Estados Unidos
NCT04810741 · Retrospective Study of Clinical Practice and Management of I…Concluído
🇫🇷 França
NCT05085470 · Repeated Controlled Human Schistosoma Mansoni InfectionConcluído
NA🇳🇱 Países Baixos
NCT04679831 · Clinical Evaluation of Ujiplus® Against Schistosoma MansoniConcluído
PHASE2, PHASE3Kenya
NCT03640377 · Praziquantel in Children Under Age 4Concluído
PHASE2Uganda · 🇬🇧 Reino Unido
NCT04269915 · Single-sex Female Controlled Human Schistosomiasis Mansoni I…Concluído
NA🇳🇱 Países Baixos
NCT03893097 · Evaluation of Artesunate-mefloquine as a Novel Alternative T…Concluído
PHASE3Senegal
NCT03910972 · Sm-TSP-2 Schistosomiasis Vaccine in Healthy Ugandan AdultsConcluído
PHASE1, PHASE2Uganda
NCT03870204 · Validation of POC-CCA Rapid Urine Test for Qualitative Detec…Concluído
Indonesia
NCT04115072 · Treatment of Female Genital Schistosomiasis (FGS) With Prazi…Concluído
PHASE2, PHASE3Madagascar
NCT03845140 · L-PZQ ODT in Schistosoma Infected ChildrenConcluído
PHASE3Côte d’Ivoire · Kenya
NCT04324853 · Helminth Infection During Pregnancy on Vitamin D Regulation:…Concluído
Gabon
NCT03799510 · Anti-Schistosomiasis Vaccine: Sm14 Phase 2b-Sn in School Chi…Concluído
PHASE2Senegal
NCT02868385 · Repeated Doses of Praziquantel in Schistosomiasis Treatment …Concluído
PHASE3Côte d’Ivoire
NCT04264130 · Effect of Artemisinin-based Combination Therapies on Schisto…Concluído
PHASE2Gabon
NCT03041766 · Study of Safety and Immune Response of the Sm14 Vaccine in A…Concluído
PHASE2Senegal
NCT02755324 · Single-sex Controlled Human Schistosomiasis Infection: Safet…Concluído
NA🇳🇱 Países Baixos
NCT02806232 · An Open Label Dose Finding Safety and Efficacy in Children a…Concluído
PHASE2🇩🇪 Alemanha
NCT02878564 · Effect of Schistosomiasis Mansoni on HIV Susceptibility and …Concluído
PHASE4Uganda
NCT02495909 · Childhood Schistosomiasis: a Novel Strategy Extending the Be…Concluído
Zimbabwe
NCT02337855 · A Phase I Study of the Safety, Reactogenicity, and Immunogen…Concluído
PHASE1🇺🇸 Estados Unidos
NCT02194712 · Detection of Schistosomiasis CAA in Travellers After High-ri…Concluído
🇳🇱 Países Baixos
NCT02105714 · Diagnosis of Neglected Tropical Diseases Among Patients With…Concluído
Côte d’Ivoire · Indonesia · Mali +1
NCT02178748 · Trial to Investigate the Effect of Schistosoma Mansoni Infec…Concluído
PHASE2Uganda
NCT02144389 · Arachidonic Acid Treatment Against Schistosomiasis Infection…Concluído
NA🇪🇬 Egito
NCT01901484 · Schistosoma Mansoni Morbidity in Children Aged 1-5 YearsConcluído
PHASE2Uganda
NCT01722539 · Impact IPT With Sulfadoxine-pyrimethamine or Sulfadoxine-pyr…Concluído
PHASE3Republic of the Congo
NCT01424410 · Health Benefits of Repeated Treatment in Pediatric Schistoso…Concluído
Zimbabwe
NCT01288872 · Praziquantel-Pharmacokinetic StudyConcluído
PHASE1Philippines
NCT01524562 · HIV Accelerated Liver Disease in UgandaConcluído
🇺🇸 Estados Unidos
NCT01529710 · Safety and Efficacy of Mirazid for Schistosomiasis TreatmentConcluído
PHASE3🇪🇬 Egito
NCT01553552 · Schistosomiasis Effect on Response to Vaccines, Anaemia and …Concluído
Senegal
NCT02162875 · Schistosoma Mansoni in Mwanza Region, TanzaniaConcluído
NATanzania
NCT03458338 · Prevalence of Chronic Kidney Disease (CKD) and Risk Factors …Concluído
🇨🇭 Suíça
NCT01214876 · Correlating Protection Against Malaria With Serum Profiles A…Concluído
Uganda
NCT01132248 · Activity of Mefloquine Against Urinary SchistosomiasisConcluído
PHASE2Gabon
NCT01054651 · A Randomised Trial of Artesunate-sulfamethoxypyrazine/Pyrime…Concluído
PHASE3Kenya
NCT00870649 · Efficacy of Bilhvax in Association With Praziquantel for Pre…Concluído
PHASE3Senegal
NCT01558336 · Schistosoma Haematobium Infections and PraziquantelConcluído
PHASE3Sudan
NCT00486863 · S. Japonicum and Pregnancy OutcomesConcluído
PHASE2Philippines
NCT00463632 · Schistosomiasis in Women of Reproductive Age in Burkina Faso…Concluído
Burkina Faso
NCT00463528 · Women and Children as the Focus for Control of Schistosomias…Concluído
NCT00463593 · Schistosomiasis in Formal and Non-Formal Schools in Uganda: …Concluído
Uganda
NCT00463931 · Using Community-Based Volunteers to Reach Non-Enrolled Schoo…Concluído
Ghana
NCT00414479 · Assessment of Anaemia Attributable to Schistosomiasis in Sch…Concluído
Kenya
NCT00463307 · Evaluation of the Use of a Urin Test Strip to Determine the …Concluído
Kenya
NCT00403611 · Evaluation of Praziquantel Dosage for Treatment of Schistoso…Concluído
PHASE4
NCT00215267 · The Effect of Praziquantel Treatment on Schistosoma Mansoni …Concluído
NAUganda
NCT00276224 · Iron Supplementation in Schistosomiasis and Soil Transmitted…Concluído
NAZambia
NCT01512277 · Clinical Trial of Bilhvax,a Vaccine Candidate Against Schist…Concluído
PHASE1🇫🇷 França
NCT00138450 · Urinary Schistosomiasis InfectionConcluído
Kenya
NCT04589390 · Selexipag for the Treatment of Schistosomiasis-Associated Pu…UNKNOWN
PHASE2🇧🇷 Brasil
NCT05999825 · Sm-p80 Schistosomiasis Challenge StudyUNKNOWN
PHASE2
NCT06182176 · Effectiveness and Cost-effectiveness of Integrated Model for…UNKNOWN
NA
NCT06055530 · Evaluation of an AI-DP for STH Deworming Programs: a Study P…UNKNOWN
NCT05788003 · Female Genital Schistosomiasis in TanzaniaUNKNOWN
NA🇮🇹 Itália · Tanzania
NCT05658614 · Anti-Schistosomiasis Sm14-vaccine in SenegalUNKNOWN
PHASE2Senegal
NCT05354258 · Feasibility and Safety of Combining Anti-malarial With Dewor…UNKNOWN
NASenegal
NCT05350462 · Adoption of L-PZQ for Schistosomiasis by Endemic Counties - …UNKNOWN
Côte d’Ivoire · Kenya · Uganda
NCT06311344 · Filling Key Research Gaps With Clinical Implications in Mans…UNKNOWN
NA🇮🇹 Itália
NCT04635553 · Monitoring Schistosome Hybrids Under Under Praziquantel Pres…UNKNOWN
Senegal
NCT04505046 · Validation of INSPiRED Innovative Smart Diagnostic Devices f…UNKNOWN
Gabon
NCT03779347 · Schistosomiasis Diagnosis Using a CAA Antigen TestUNKNOWN
PHASE3Gabon
NCT03133832 · The Chinese-made Praziquantel for Treatment of Schistosoma H…UNKNOWN
PHASE3Tanzania
NCT03187366 · Schistosomiasis in SenegalUNKNOWN
NASenegal
NCT01869465 · Evaluation of Strategies for Improved Uptake of Preventive T…UNKNOWN
NAUganda
NCT01541631 · A Study of Co-infections of HIV-1 and Schistosoma Mansoni an…UNKNOWN
NATanzania
NCT01459146 · Artemisinin-based Combination Therapy-Intermittent Preventiv…UNKNOWN
PHASE4Ghana
NCT01154907 · Prevention of Female Genital Schistosomiasis (FGS) in Rural …UNKNOWN
South Africa
NCT01260012 · Antioxidant Supplements in the Reversal of Schistosomal Peri…UNKNOWN
NAEthiopia
NCT03158298 · Seropositivity and Adverse Birth Events in Migrants From Bil…Encerrado
🇩🇪 Alemanha
NCT02810613 · Leiden University Medical Center Mini Donor BankCancelado
NCT02734186 · Effect of Concomitant Mansonella Perstans Microfilaremia on …Cancelado
PHASE4
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
6.937 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 6.937

#1

Rapid identification of Biomphalaria spp. and diagnosis of Schistosoma mansoni infestation using MALDI-TOF mass spectrometry.

PLoS neglected tropical diseases2026 Mar 24

This study explores the use of Matrix-Assisted Laser Desorption/Ionization Time-of-Flight mass spectrometry (MALDI-TOF MS) to identify and differentiate Biomphalaria snails infected with the parasite S. mansoni, which causes schistosomiasis. The study was conducted on two snail species, Biomphalaria pfeifferi (collected in the field in Senegal) and Biomphalaria glabrata (a laboratory strain). The snails were infected in the laboratory with S. mansoni miracidia, and their infection was confirmed by cercariae emission tests and quantitative PCR (qPCR). MALDI-TOF MS was then used to analyse proteins from infected and uninfected snails to identify spectral differences. Based on protein profiles, the results of MALDI-TOF mass spectrometry made it possible to accurately differentiate between S. mansoni-infected snails and uninfected snails. An increase in the number of peaks detected and their intensity was observed for the spectra of S. mansoni-infected snails compared to uninfected snails. The application of principal component analysis (PCA) to these mass spectrometry profiles confirmed the discrimination between the two groups according to their infection status. In addition, specific discriminating peaks were identified for each snail species, allowing for the distinction of infected from uninfected snails. The present study revealed, for the first time, that MALDI-TOF MS appears to be a rapid, reliable, and specific tool for the diagnosis of schistosomiasis in snails, offering promising prospects for the surveillance and control of this disease in endemic areas. However, further work is needed to establish a MALDI-TOF MS reference spectra database specific to Schistosoma parasites and to standardise sample collection, storage, and preparation in order to apply this technique in the field.

#2

Optimising DTwP-containing vaccine infant immunisation schedules in Uganda and Nepal (OptImms): two open-label, non-inferiority, randomised controlled trials.

The Lancet. Infectious diseases2026 Mar 19

Few data are available comparing the WHO diphtheria-tetanus-pertussis (DTP)-containing vaccine schedule with reduced-dose or delayed three-dose schedules in infants. We aimed to identify an alternative schedule that is non-inferior or superior to the WHO schedule in maintaining early pertussis antibody levels before booster, while creating space for integration of new vaccines. In two parallel, open-label, randomised, non-inferiority trials in Uganda and Nepal, healthy infants aged 42-50 days were randomised in a 4:4:4:3:3 ratio via an online system to five diphtheria-tetanus-whole-cell pertussis-Haemophilus influenzae type b-hepatitis B (DTwP-Hib-HepB) vaccination schedules (WHO schedule [ages 6, 10, and 14 weeks]; reduced two-dose schedules at ages 6 and 14 weeks or ages 2 and 4 months; or delayed three-dose schedules at ages 2, 3, and 4 months or ages 2, 4, and 6 months), using site-stratified block randomisation with a block size of 18. The primary outcome was the pre-booster IgG antibody response against pertussis antigens (pertussis toxin; filamentous haemagglutinin [FHA]; pertactin; fimbriae 2 and 3 [Fim 2 and 3]). Antibody responses during and 1 month after the primary series were assessed as secondary endpoints. The two-dose schedules were compared with the WHO schedule as primary analyses, and the exploratory analyses were to compare delayed three-dose schedules with the WHO schedule. All these analyses were conducted in the per-protocol population. For the primary endpoint, non-inferiority margins for geometric mean ratios (GMRs) between two-dose and WHO schedules were calculated for each pertussis antigen separately as 35% of the standard deviation of the geometric mean concentrations of the WHO group, and non-inferiority was concluded if the lower bound of the 95% CI of the GMR exceeded the non-inferiority margin. A non-inferiority margin of 0·67 was used for all other non-inferiority comparisons. The trials were registered with ISRCTN (Uganda [ISRCTN60356654] and Nepal [ISRCTN12240140]) and are complete. Between Oct 1, 2021, and July 12, 2022 (Uganda) and Dec 5, 2021, and Feb 26, 2023 (Nepal), 956 infants were recruited per country and randomly allocated across the five study groups; pre-booster analyses were conducted in 876 participants in Uganda and 851 participants in Nepal. Two-dose schedules at ages 6 and 14 weeks and ages 2 and 4 months did not meet non-inferiority criteria for pertussis antibodies pre-booster, except FHA (non-inferiority margin 0·59) in Nepal (6 and 14 weeks GMR 0·83 [95% CI 0·61-1·13]; 2 and 4 months 1·20 [0·88-1·64]). Delayed three-dose schedules at ages 2, 3, and 4 months and ages 2, 4, and 6 months produced similar or higher post-primary series and pre-booster responses compared with the WHO schedule, but the WHO schedule achieved higher antibody responses against all pertussis antigens, except FHA in Nepal, at age 3 months. The WHO DTP schedule is the preferred schedule in high-pertussis-burden settings, as it elicits the greatest antibody responses in the first 3 months of life when infants are particularly vulnerable. Although delayed three-dose schedules may be considered in low-risk contexts and in settings with maternal immunisation programmes, early infant protection should guide policy decisions. Gates Foundation.

#3

Prevalence, infection intensity, and risk factors of soil-transmitted helminthiasis and intestinal schistosomiasis among schoolchildren in Southern Ethiopia.

PLoS neglected tropical diseases2026 Mar 18

Soil-transmitted helminthiasis (STH) and intestinal schistosomiasis are widespread and prevalent in tropical regions due to poor sanitation and limited healthcare access. Despite control efforts, localized epidemiological data remain essential for effective intervention. This study aimed to assess the prevalence of STH and associated factors among schoolchildren in Hawella Tulla sub-city, Hawassa City, Sidama National Regional State, Ethiopia. A school-based cross-sectional study involving 394 primary schoolchildren was conducted from June to December 2023. Data were collected using an interviewer-administered questionnaire. Infection with the parasite was diagnosed by Kato-Katz microscopy. Bivariate and multivariable logistic regression were used to identify factors associated with the STH infections. The combined prevalence of soil-transmitted helminths (STHs) and intestinal schistosomiasis was 42.6% (168/394; 95% CI: 37.8-47.6). STHs constituted the predominant infection, detected in 41.1% of children (162/394; 95% CI: 36.3-46.0), while intestinal schistosomiasis was found in 3.3% (13/394; 95% CI: 1.9-5.4). The most prevalent parasite was Ascaris lumbricoides (29.2%), followed by Trichuris trichiura (17.8%) and hookworms (5.1%). Schoolchildren who reported consuming unwashed fruits or vegetables (AOR: 2.89; 95% CI: 1.73-4.85), swimming or bathing in streams or lakes (AOR: 2.23; 95% CI: 1.31-3.79), and not receiving deworming treatment (AOR: 2.12; 95% CI: 1.26-3.56) were significantly more likely to be infected with soil-transmitted helminths (STHs). Overall, soil-transmitted helminthiasis (STHs) and Schistosoma mansoni remain significant public health concerns in the study area, affecting more than one-third of schoolchildren. Infections were strongly associated with poor hygiene practices, inadequate deworming coverage, and exposure to contaminated water sources. This highlights the need for improved hygiene, health education, and deworming programs.

#4

An artificial intelligence-powered digital pathology platform to support large-scale deworming programs against soil-transmitted helminthiasis and intestinal schistosomiasis in resource-limited settings.

PLoS neglected tropical diseases2026 Mar 18

The World Health Organization (WHO) has emphasised the need for innovative diagnostic tools to support the control and elimination of neglected tropical diseases (NTDs). Microscopy-based diagnostics, the current standard, rely on trained technicians for labour-intensive processes, posing logistical challenges in the low-resource settings where NTDs are most prevalent. This study describes the technical details of an artificial intelligence-powered digital pathology (AI-DP) platform designed to support large-scale deworming programs for two NTDs, alongside its analytical performance and user experience in laboratory and field settings. The AI-DP platform integrates electronic data capture tools, whole-slide imaging scanners, onboard AI analysis, and result verification software to automate microscopy-based screening. Targeting soil-transmitted helminthiasis (STH) and intestinal schistosomiasis (SCH) as initial use cases, the system was deployed in Ethiopia and Uganda, scanning 951 Kato-Katz (KK) thick smears containing 43,919 verified helminth eggs. Using 5-fold cross-validation, precision/recall/average precision were 95.4%/91.7%/97.1% for Ascaris lumbricoides, 95.9%/86.7%/94.8% for Trichuris trichiura, 84.6%/86.6%/91.4% for hookworm, and 89.1%/79.1%/89.2% for Schistosoma mansoni. Feedback from 14 field users across 30 real-world scenarios indicated the AI-DP platform's improved usability, particularly in hardware portability and software interfaces, though the average scan time of 12.5 minutes per smear was identified as a limitation. The AI-DP platform demonstrates potential as a tool for efficient monitoring and evaluation of STH and SCH control programs by providing near-real-time data with quality controls. However, further validation studies are needed to assess its clinical diagnostic performance, field usability, and cost-effectiveness in large-scale STH and SCH deworming programs. Given that the platform also provides a pipeline for any microscopy-based diagnosis, its potential for other NTDs also needs further attention.

#5

Olfactory gene profiling in ticks: A scoping review with a functional perspective.

Veterinary and animal science2026 Jun

Olfaction is important in ticks' host-seeking and mating behaviors, as it enables them to detect volatile chemical compounds. This scoping review aims to systematically map and synthesize the existing literature on olfactory gene families in ticks and to examine the application of functional genomics or behavioral approaches. We conducted a thorough search in five databases for publications up to 19 September 2025. This scoping review was implemented according to the Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) guidelines. A total of 15 studies were included in this review, and 12 tick species were reported. Among these, Haemaphysalis longicornis and Ixodes scapularis had the most olfactory genes identified. Ten related olfactory gene families were identified in the 12 tick species. Among these, Niemann-Pick type C2 protein families were the most frequent across tick species (n = 11), followed by gustatory receptor and ionotropic receptor families (n = 7). Additionally, the studies reviewed found differences in gene family distributions among tick species. Molecular methods were used to identify olfactory genes, with most studies reporting RNA sequencing and reverse transcription quantitative PCR. A small number of studies used functional validation techniques such as RNA interference, ligand-binding assays, molecular docking, electroantennography, or Y-tube olfactometer assay. This scoping review highlights significant progress in the molecular understanding of tick olfaction. It emphasizes the importance of advancing this knowledge to improve comprehension of molecular tick olfactory and enable the development of targeted, olfaction-driven tick control and tick-borne disease prevention strategies.

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📚 EuropePMC12.328 artigos no totalmostrando 199

2026

Surface-modified nanocarriers in the design of targeted drug delivery systems for parasitic diseases: a comprehensive review.

BMC chemistry
2026

Imported Schistosoma intercalatum/guineensis infection: a retrospective study from a referral Tropical Medicine Unit in Barcelona, Spain.

BMC infectious diseases
2026

Rapid identification of Biomphalaria spp. and diagnosis of Schistosoma mansoni infestation using MALDI-TOF mass spectrometry.

PLoS neglected tropical diseases
2026

Proteasomal-dependent endothelial P2Y6 receptor downregulation as an adaptive mechanism limiting monocyte adhesion during intestinal schistosomiasis.

Purinergic signalling
2026

Visual Detection for Environmental Antimicrobial Resistance Genes by Recombinase Polymerase Amplification Combined with Lateral Flow Dipstick.

Current microbiology
2026

Host genetic background influences the severity of disease in Schistosoma haematobium infections.

Parasite (Paris, France)
2026

Comprehensive Schistosoma mansoni Hierarchical Transcriptome Assembly Points to Novel lncRNAs Associated with Sexual Dimorphism.

Non-coding RNA
2026

Improved serological testing for bovine schistosomiasis in Eastern Africa.

Parasites &amp; vectors
2026

Pleural Effusion with Schistosoma Ova in Cytologic Smears: A Rare Case Report in an Elderly Patient.

Acta cytologica
2026

Optimising DTwP-containing vaccine infant immunisation schedules in Uganda and Nepal (OptImms): two open-label, non-inferiority, randomised controlled trials.

The Lancet. Infectious diseases
2026

TRPtracker: a community database for monitoring praziquantel sensitivity at TRPMPZQ variants.

International journal for parasitology. Drugs and drug resistance
2026

A Comprehensive Review of Endoparasite Infections in Marine Fish: Prevalence, Infection Factors, and Dominant Species.

Current microbiology
2026

Clinical and hemodynamic evaluation of schistosomiasis-associated pulmonary arterial hypertension from Egyptian pulmonary hypertension centers: epidemiology, risk factors, and survival determinants.

Scientific reports
2026

Spinal cord Schistosomiasis in a 26-year-old male patient with progressive lower limb weakness and sensory loss: A case report.

IJID regions
2026

Molecular Detection of Schistosomiasis Using Real-Time PCR Before and After Treatment in Dumbi Communities, Kaduna State, Nigeria.

Cureus
2026

Spatial distribution of urogenital schistosomiasis in school-aged children in Togo: an oversampling survey in three districts in 2022.

Parasites &amp; vectors
2026

Prevalence, infection intensity, and risk factors of soil-transmitted helminthiasis and intestinal schistosomiasis among schoolchildren in Southern Ethiopia.

PLoS neglected tropical diseases
2026

An artificial intelligence-powered digital pathology platform to support large-scale deworming programs against soil-transmitted helminthiasis and intestinal schistosomiasis in resource-limited settings.

PLoS neglected tropical diseases
2026

Olfactory gene profiling in ticks: A scoping review with a functional perspective.

Veterinary and animal science
2026

Sub-microscopic schistosomiasis and soil-transmitted helminths in school children: molecular diagnostic evidence and implications for disease elimination.

Scientific reports
2026

Rapid Nutritional Screening and Short-Term Prognosis in Advanced Schistosomiasis: A Prospective Cohort Study.

Acta parasitologica
2026

Three decades of change: schistosomiasis, hepatitis C, and the rise of metabolic dysfunction-associated steatotic liver disease in Egypt.

Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology
2026

The human immunome in the post-schistosomiasis mass drug administration era.

PLoS neglected tropical diseases
2026

Incidental appendectomy identifying appendiceal schistosomiasis during elective TAPP inguinal hernia repair: a case report.

International journal of surgery case reports
2025

50-Year Bibliometrics of International Scientific Biomedical Publications on "Parasitic Diseases": MEDLINE (1970-2019).

La Tunisie medicale
2026

Incidence, trend and distribution of reported cases of schistosomiasis to health facilities in the Volta Region, Ghana, 2019-2023.

BMC infectious diseases
2026

Modifications of the Helmintex Method: Integration of Treatments With Tween 20, Cellulase, Percoll and Auramine-O Staining for Detection of Schistosoma mansoni Eggs.

Tropical medicine &amp; international health : TM &amp; IH
2026

The CD163:CD68 Ratio Reflects Splenic Macrophage Remodelling in Murine Chronic Schistosomiasis.

Parasite immunology
2026

Association between female genital schistosomiasis and high-risk human papillomavirus among women of reproductive age in Zambia: the Schista study.

The Journal of infectious diseases
2026

Mass drug administration of praziquantel lowers the susceptibility of school-aged children to Schistosoma mansoni in endemic areas.

Frontiers in immunology
2026

Pilot assessment of point-of-care differential white blood cell count analysers in schoolchildren with schistosomiasis.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2026

Schistosome esophageal gland factor MEG-8.2 drives host cell lysis and interacts with host immune proteins.

PLoS pathogens
2026

Miracidia as main source for autofluorescence of Schistosoma mansoni eggs.

Memorias do Instituto Oswaldo Cruz
2026

Comprehensive identification and co-expression analysis of long non-coding RNAs across eight timepoints of Schistosoma mansoni life cycle.

Memorias do Instituto Oswaldo Cruz
2026

Prevalence, Intensity, Risk Factors, and Haematological impact of Schistosomiasis among School-Aged Children in Osun State, Nigeria.

Journal of vector borne diseases
2026

Fine-scale mapping of Oncomelania hupensis habitats in eastern China using multi-season Sentinel-2 imagery and semi-supervised deep learning.

Acta tropica
2026

TIGIT impairs NK cell antifibrotic activity through the IFNγ-IFI30 axis in schistosomiasis-induced liver fibrosis.

Frontiers in immunology
2026

RALP1 is essential for schizont maturation and erythrocyte invasion in Plasmodium falciparum.

Parasites &amp; vectors
2026

A male-pheromone-elevated transcription factor ZNF362.1 in female schistosomes determines sexual maturation.

Science advances
2026

Prevalence and associated factors of non-variceal upper gastrointestinal bleeding among cirrhotic patients with upper gastrointestinal bleeding on follow-up at a Tertiary Hospital in Ethiopia.

PloS one
2026

Schistosoma infection as a cause of myeloradiculopathy: case report from Mozambique and systematic review.

Frontiers in medicine
2026

Image segmentation of cervical grainy sandy patches lesions associated with female genital schistosomiasis using deep convolutional neural network with U-NET architecture.

PLoS neglected tropical diseases
2026

Molecular diagnostics reveal substantial sub-patent schistosomiasis and soil-transmitted helminth infections in school children: An implication for elimination programme.

Acta tropica
2026

IgG subclass-based serodiagnosis of Schistosoma mansoni using C-type lectin-derived peptides.

Diagnostic microbiology and infectious disease
2026

Schistosoma mansoni soluble egg antigen and its key proteins differentially affect dextran sodium sulphate-induced inflammatory bowel disease.

Memorias do Instituto Oswaldo Cruz
2025

Prevalence and factors associated with urinary schistosomiasis in women attending cervical cancer screening in Sithobela, Eswatini: A facility-based cross-sectional study.

Helminthologia
2025

Green synthesis of zinc oxide (ZnO) nanoparticles using aqueous leaves extracts of Artemisia annua: Their characterizations and anti-parasitic activity.

Helminthologia
2026

Rare Enterobius vermicularis infection of the greater omentum misdiagnosed as schistosomiasis: a case report.

Infectious diseases of poverty
2026

Bayesian machine learning enables discovery of risk factors for hepatosplenic multimorbidity related to schistosomiasis.

Nature communications
2026

The underestimated burden of placental schistosomiasis in endemic regions: Findings from a cross-sectional, diagnostic proof-of-concept study on placental schistosomiasis in Gabon.

PLoS neglected tropical diseases
2026

A Hidden "Promoter": Schistosoma japonicum soluble egg antigen activates MAPK/PI3K-AKT pathways and inhibits autophagy to facilitate colorectal cancer.

Infection and immunity
2026

Schistosoma Species and Hybrid Genotyping With a Field Deployable Multi-Marker Amplicon Panel.

Current protocols
2026

Unmasking Parasitic Colitis Mimicking Inflammatory Bowel Disease.

Cureus
2026

Surface Charge-Dependent Targeting and Penetration of Magnetic Nanoparticles into Eggs and Adult Worms of Schistosoma japonicum.

Pharmaceutics
2026

Identification of Ferroptosis-Related Hub Genes Linked to Suppressed Sulfur Metabolism and Immune Remodeling in Schistosoma japonicum-Induced Liver Fibrosis.

Pathogens (Basel, Switzerland)
2026

Single-Imaging Parasite-Quantification Microfluidic Device for Detection and Analysis of Schistosoma Eggs in Urine.

Micromachines
2026

Limited impact of schistosome infection on Biomphalaria glabrata snail microbiomes.

Parasites &amp; vectors
2026

Ecological influences on host-parasite dynamics among Biomphalaria snails in two schistosomiasis endemic regions of Kenya.

Frontiers in parasitology
2026

Schistosome-derived microRNAs: promise, pitfalls and priorities for molecular diagnosis.

Infectious diseases of poverty
2026

Usefulness of environmental DNA for Biomphalaria glabrata and Schistosoma mansoni surveillance and control of low schistosomiasis endemic areas in Brazil.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
2026

One health at the last mile: Multi-scale predictors of Schistosoma japonicum infection in southwest china across two decades of control.

PLoS neglected tropical diseases
2026

[Urogenital schistosomiasis].

La Revue du praticien
2026

Extracellular Vesicle Properties and Functions Are Defined by the Originating Cell's Fitness Status.

Journal of extracellular biology
2026

Prediction of 6-year mortality in advanced splenomegaly-subtype schistosomiasis: a retrospective cohort study from Hubei, China.

BMJ open
2026

AID-FGS: Artificial intelligence-enabled diagnosis of female genital schistosomiasis: Preliminary findings.

PLOS digital health
2026

Alternate-Day Fasting Exacerbates Lung Inflammatory Disease Compared to High-Sucrose Diet in Experimental Schistosomiasis Mansoni.

Parasite immunology
2026

CX3CL1/CX3CR1 axis in liver disease: context-dependent roles and balance.

Frontiers in immunology
2026

The Fight is not Over: Sustained Vigilance Against Schistosomiasis Needing in China.

Acta parasitologica
2026

Implications of host sex on liver metabolism during Schistosoma mansoni Infection.

Frontiers in cellular and infection microbiology
2026

Genetic Characterization of Schistosoma Species from Goats in Pakistan Using the 28S rDNA Region.

Indian journal of microbiology
2026

Liver and bladder morbidity in a Schistosoma mansoni and haematobium co-endemic area in the Democratic Republic of Congo.

PLoS neglected tropical diseases
2026

Prevalence, intensity and predictors of intestinal schistosomiasis among fishermen in Ilemela Municipality, Tanzania.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2026

Impact of pre-treatment food on praziquantel absorption, metabolism, treatment-associated side effects, and drug efficacy: a systematic review and meta-analysis protocol.

Systematic reviews
2026

Evaluating short-term changes in helminth burdens using sequential community-based surveys in Rwanda.

Scientific reports
2026

Cerebral schistosomiasis masquerading as a CNS malignancy in a sudanese traveler: A diagnostic challenge and review of literature.

Travel medicine and infectious disease
2026

Distribution and Prevalence of Schistosome Infection among Intermediate Snail Hosts in Ethiopia: A Systematic Review and Meta-Analysis.

Acta parasitologica
2026

Alterations in gut microbiota and their association with nutrition and disease progression in advanced schistosomiasis.

Acta tropica
2026

A functional switch of Galectin-1: A glycan-dependent driver of liver cancer progression.

Biochimica et biophysica acta. Reviews on cancer
2025

Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals the transcriptome profile of Microtus fortis immune cells during the early phase of infection with Schistosoma japonicum.

Frontiers in cellular and infection microbiology
2026

Real-world efficacy and prognostic factors of CDK4/6 inhibitors in HR+/HER2- metastatic breast cancer: a multicenter retrospective study from the Dongting Lake region of China.

Translational breast cancer research : a journal focusing on translational research in breast cancer
2026

KIF20A inhibits TRIM21-dependent ubiquitination of DHX9 to boost SOX2 stability, enhancing OSCC stemness and ferroptosis resistance.

Cell death &amp; disease
2026

Chronic Schistosomiasis Infection Dose not Affect the Prognosis of Gastric Cancer Patients.

Journal of gastrointestinal cancer
2026

Imaging evaluation and management of liver infections: a multimodality review.

Abdominal radiology (New York)
2026

The Transformative Impact of Deep Learning and Artificial Intelligence on Parasitic Disease Diagnosis.

Clinical laboratory
2026

Distribution of Biomphalaria sp. and other limnic mollusks in the state of Ceará: a potential effect of the São Francisco River Transposition Project.

Revista da Sociedade Brasileira de Medicina Tropical
2026

Primed mesenchymal stem cells attenuate schistosomiasis fibrosis by enhancing macrophage subset switching and efferocytosis via Itgb2-Rac1 axis.

Cell death discovery
2026

Heat shock protein 90 as a vital signalling hub in Schistosoma mansoni: a master regulator of stem cell proliferation, development and survival.

Open biology
2026

Associations of Schistosoma mansoni Infection, Latent Tuberculosis, Host Interferon-γ Concentrations, and Praziquantel Treatment in Tanzanian Adults.

The American journal of tropical medicine and hygiene
2026

Bleeding rectal polyp as an atypical presentation of intestinal schistosomiasis: A case report from Egypt.

PLoS neglected tropical diseases
2025

From local triumph to global learning: Gimavi village & the journey toward schistosomiasis elimination.

The Indian journal of medical research
2026

Feasibility of a phase 3 partially randomised clinical trial to assess the safety and efficacy of paediatric praziquantel for schistosomiasis treatment in children aged 3 months to 6 years in endemic regions of Brazil: a pilot study.

BMJ open
2026

Characterization of Transcriptional, Epigenetic, and Phenotypic Plasticity and Discovery of Biomarkers in Acute and Chronic Murine Schistosomiasis Infection.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2025

Minimal hepatic encephalopathy in hepatosplenic schistosomiasis: High prevalence and association with portosystemic shunts in a Brazilian cross-sectional study.

World journal of hepatology
2026

Snail 3G: genomics, genetics, and gene-editing of Biomphalaria glabrata.

Frontiers in genetics
2026

Enhanced surgical tolerance of schistosomiasis-induced fibrotic liver following treatment with Ziziphus plant extract.

World journal of hepatology
2026

Barriers in managing maternal schistosomiasis: a qualitative study of healthcare providers in Tanzania.

International health
2026

The vaginal microbiota of adult Malagasy women of reproductive age in the Marovoay district: first characterization and exploration of associations with human papillomavirus and Schistosoma haematobium infections.

The Journal of infectious diseases
2026

Female genital schistosomiasis (FGS) in migrants - a systematic review of reported cases.

BMC women's health
2026

Clinical and epidemiological features of schistosomiasis among sub-Saharan African migrants in Barcelona, Spain: a retrospective observational study.

Infectious diseases of poverty
2026

The gut microbiome and metabolome associate with Schistosoma mansoni infection and cardiovascular disease risk in Uganda.

Nature communications
2026

Distinct quaternary reaction behavior and stable charge-transfer complex formation in Schistosoma mansoni sulfide:quinone oxidoreductase.

Free radical biology &amp; medicine
2026

IL-6 and TGF-β1 as biomarkers of schistosomiasis-associated pulmonary hypertension in a murine model.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
2026

Recurrent Hematuria Unmasking a Rare Case of Bladder Schistosomiasis in a Child Living in a Non-endemic Country: A Case Report.

Cureus
2026

Optimization and validation of a TaqMan real-time PCR for the detection of Heterobilharzia americana in dog feces.

Veterinary parasitology
2026

Evaluation of surveillance-response interventions for Schistosoma haematobium elimination on Pemba Island, Tanzania: A 4-year intervention study with repeated cross-sectional surveys.

PLoS neglected tropical diseases
2026

Effects of anxiety on thyroid nodules among Adolescents - A Cross-sectional study from Jiangsu, China.

Endocrine
2026

Prevalence of schistosome infection in a region of Madagascar regularly undergoing mass drug administration: a cross-sectional study.

Pathogens and global health
2026

Schistosomal appendicitis: a case series.

Journal of surgical case reports
2026

Confronting neglected tropical diseases: a moral and strategic imperative for global equity.

Infectious diseases of poverty
2026

Liver and spleen ultrasonography and elastography are useful for identifying a history of upper gastrointestinal bleeding in patients with schistosomiasis.

BMC infectious diseases
2026

Hidden in Plain Sight: The Enduring Challenge of Neglected Tropical Diseases in Khartoum State, Sudan.

Journal of tropical medicine
2025

From cercariae to chronic inflammation: understanding schistosome infection and host immune responses.

Frontiers in immunology
2026

Schistosomiasis in Saudi Arabia (2002-2024): A National Analysis of Trends, Regional Heterogeneity, and Progress Toward Elimination.

Tropical medicine and infectious disease
2026

Imported Eosinophilia in Migrants from Endemic Areas in Spain.

Tropical medicine and infectious disease
2026

Antischistosomal activity of imidazolidine-2,4-dione derivatives.

Antimicrobial agents and chemotherapy
2026

Hepatic Angiosarcoma Associated with Chronic Schistosomiasis in a Patient with Decompensated Cirrhosis: A Rare Case Report.

Case reports in gastroenterology
2026

Pseudocirrhotic Turtle Back Liver in Remote Schistosomiasis.

ACG case reports journal
2025

The DEAD-box RNA helicase eIF4A is a crucial factor for stem-cell activity and reproduction of the parasite Schistosoma mansoni.

Frontiers in cellular and infection microbiology
2026

Case report: Radiographic and cystoscopic manifestations of chronic urogenital Schistosomiasis in an asymptomatic Zimbabwean man with HIV.

Urology case reports
2026

APOE ε4 Allele Modifies the Association of Heavy Metals and their Mixture with Diabetes Mellitus among Chinese Community-Dwelling Older Adults.

Biomedical and environmental sciences : BES
2026

Association between Schistosoma mansoni infection and fecal occult blood in schoolchildren in Mbita, Suba North sub-county, western Kenya.

Tropical medicine and health
2026

Differential expression and prognostic role of ACACA, ACLY, and FASN in schistosomiasis-associated versus hepatitis B virus-related liver cancer.

Infectious agents and cancer
2026

The P2X7 Receptor and Its Relation to Neglected Tropical Diseases: Focusing on Chagas Disease.

Journal of tropical medicine
2026

Dynamic single-cell transcriptomics reveals lsamp-guided neural network formation in male S. japonicum driving female reproduction.

Nature communications
2026

Long-term persistence of Schistosoma mansoni hotspots in western Kenya despite ongoing mass drug administration.

Current research in parasitology &amp; vector-borne diseases
2026

Repeated biannual cross-sectional surveys in primary schools set baseline seasonal and spatial surveillance for malaria and schistosomiasis in the Shire Valley Transformation Programme (SVTP), Malawi.

Current research in parasitology &amp; vector-borne diseases
2026

Mzb1 Promotes Progression of Schistosomiasis by Inducing Endoplasmic Reticulum Stress.

The Journal of infectious diseases
2025

Neonatal and maternal adverse outcomes among low-risk nulliparous women compared with multiparous women at 37-41 weeks of gestation: a cohort study in South China.

Frontiers in medicine
2026

Temporal variability and flooding influence the ecological niche of Biomphalaria intermediate hosts for Schistosoma mansoni in rural Uganda.

Proceedings. Biological sciences
2026

Endothelial cells protect Schistosoma mansoni from hydrogen peroxide-induced death.

PLoS neglected tropical diseases
2026

Health needs assessment for tropical vector-borne disease prevention among Chinese expatriate workers in Africa: a cross-sectional study.

BMC public health
2026

Sex in Immune Cells and Parasitic Diseases - A Complex Relationship.

Immunological reviews
2026

Tissue-specific and sex-biased glycoproteomic landscape of Schistosoma mansoni.

Nature communications
2026

Imported female genital schistosomiasis: a neglected health issue across borders.

Journal of global health
2026

High prevalence of schistosomiasis among resettled Rohingya refugees.

Journal of travel medicine
2026

Advancing schistosomiasis monitoring through optimised environmental DNA detection.

Food and waterborne parasitology
2026

Public health challenge of hybridization in urogenital schistosomiasis: New insights and one health perspectives from Malawi.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

Dynamic interactions between Schistosoma haematobium, Schistosoma mattheei and Schistosoma mansoni underscore the complex polyparasitism of intestinal schistosomiasis in southern Malawi.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

Clinical morbidity of single or mixed schistosome species infection in two communities of southern Malawi.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

One Health insights into local transmission of zoonotic Schistosoma mattheei in southern Malawi.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

Multidisciplinary challenges by 'pure' and hybrid Schistosoma species introduced into southwestern Europe.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

Finding hybrid schistosomes in genital schistosomiasis: are we missing their clinical relevance?

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

Transcriptomic plasticity in hybrid schistosomes can contribute to their zoonotic potential.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

Not all 'hybrids' matter: towards a nuanced understanding of Schistosoma species hybridization.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

Cross-reactivity and localization of Schistosoma mansoni antigen for immunodiagnosis.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
2026

Prevalence of schistosomiasis and associated risk factors in endemic communities: cross-sectional study, Patioba and Colônia Miranda, Sergipe, 2022-2023.

Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil
2026

Allergic airway inflammation of offspring mice is suppressed by breast milk from Schistosoma mansoni-infected mothers.

Brazilian journal of biology = Revista brasleira de biologia
2026

Tracking the spatial and longitudinal dynamics of mixed infections of urogenital and intestinal schistosomiasis, inclusive of Schistosoma mattheei, in two sentinel rural communities from southern Malawi.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

Variable efficacy of praziquantel among Schistosoma-infected ruminants of northern Senegal-a drug trial and population genetic study across two contrasting epidemiological regions.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

African zoonotic schistosomiasis: a paradigm shift.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2026

Invasive patterns of Biomphalaria straminea revealed by genetic mapping in the Greater Bay Area, China.

Infectious diseases of poverty
2026

Crystal structure of Echinococcus multilocularis cystatin B reveals a novel feature in classical stefins.

Scientific reports
2025

Enhancing serological diagnosis of urogenital schistosomiasis with admixtures of antigens from Schistosoma eggs and worms.

Journal of infection in developing countries
2026

Prevalence, risk factors and trends of human schistosomiasis in Côte d'Ivoire from 1974-2023: systematic review and meta-analysis.

Infectious diseases of poverty
2026

Circulating microRNAs in pulmonary arterial hypertension: biomarkers for diagnosis, prognostic stratification, and treatment.

GeroScience
2026

Schistosomal appendicitis in Qatar: a rare parasitic cause of acute appendicitis in a non-endemic region.

Journal of surgical case reports
2026

A reservoir at the gates: nonhuman mammalian hosts for human schistosomiasis in western Africa and the critical challenge for elimination.

Infectious diseases of poverty
2026

Diagnosis of female genital schistosomiasis and pre-emptive treatment with praziquantel: a community-based pilot intervention study in Tiko, Cameroon.

Reproductive health
2026

Schistosomiasis, endless endemicity since the ancient Egyptians.

BMC infectious diseases
2026

Chronic Exposure to Niclosamide Disrupts Structure and Metabolism of Digestive Glands and Foot in Cipangopaludina cathayensis.

Biology
2026

An automated end-to-end system for schistosome viability assessment to accelerate anti-schistosomal drug discovery.

PLoS neglected tropical diseases
2026

Evidence-based decision-making support for determining the risk of schistosomiasis infection during large events in China: Application of risk assessment.

PLoS neglected tropical diseases
2026

Schistosomiasis japonica transmission dynamics: mathematical modeling in guiding One Health approach control strategies.

Infectious diseases of poverty
2026

Impact of nonpharmaceutical interventions on infectious disease patterns in Yunnan Province across the COVID-19 pandemic phases.

BMC infectious diseases
2026

Resistance evaluation and surveillance initiative for schistosomiasis treatment: study protocol for the RESIST project.

BMC infectious diseases
2026

Community survey of the infection, intensity and risk factors associated with schistosomiasis and soil-transmitted helminthiasis in south-eastern Gabon.

Scientific reports
2026

Prevalence of Schistosoma bovis and Schistosoma haematobium hybrids in endemic communities in Ghana.

PloS one
2025

Cattle Schistosomiasis With Farmers' Practice Regarding the Prevention and Control of Zoonotic Trematodes in Maya City, Eastern Ethiopia.

Journal of parasitology research
2026

The regional impact and control strategies of schistosomiasis in Rwanda, Tanzania, and Uganda: a narrative review.

Annals of medicine and surgery (2012)
2026

Molluscicidal Activity of Camellia Sinensis (Green Tea) and Camellia sinensis var. Assamica (Purple Tea) Extracts Against Biomphalaria pfeifferi, the Major Vector Snail of Human Schistosomiasis in Sub-Saharan Africa.

Journal of parasitology research
2026

Schistosoma japonicum infection: clinical significance of ultrasound findings.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2026

Mavacamten in hypertrophic obstructive cardiomyopathy with hepato-renal comorbidities: A case report.

Medicine
2026

The role of quantitative T1 and T2 mapping for detecting minimal hepatic encephalopathy in chronic hepatic schistosomiasis patients.

PloS one
2025

Pancreatic Schistosomiasis, China, 2020-2024.

Emerging infectious diseases
2026

Prognostic determinants and mortality risk of advanced schistosomiasis revealed by Lasso-Cox regression integrative approach.

PLoS neglected tropical diseases
2026

Topic: Xenomonitoring of Schistosoma intermediate hosts for evaluating community-wide mass drug administration in Ghana: preliminary findings and lessons.

Transactions of the Royal Society of Tropical Medicine and Hygiene
2026

Epidemiology of Schistosoma haematobium infection and microhaematuria among schoolchildren in a setting of sustained mass drug administration in Banfora, Burkina Faso.

Parasite epidemiology and control
2026

Spinal cord schistosomiasis: A case report.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
2026

Peer-led versus routine health education for schistosomiasis knowledge improvement among primary school students in Wuhan, China.

PLoS neglected tropical diseases
2025

Getting into host's skin: initial immune response to Schistosoma mansoni infection.

Frontiers in immunology
2025

Neglected by Design: Occupational Parasitic Infections in India's Lower Castes.

The Yale journal of biology and medicine
2025

Temporal modulation of gene expression in a controlled Schistosoma mansoni human infection model.

Frontiers in immunology
2025

Acetylene Acetogenin from Porcelia macrocarpa Exhibits Superior Efficacy against Schistosoma mansoni In Vivo.

ACS omega
2025

Implementation of the community health system innovation project in three low- and middle-income countries: COHESION-I study protocol.

BMJ open
2025

HIV, Viral Hepatitis, and Schistosomiasis Association with Liver Cancer: A Systematic Review.

Microorganisms
2025

No Histopathological Evidence of Inflammation Despite Molecular Detection of Schistosoma spp. and Sexually Transmitted Pathogens in Placental Parenchyma Specimens with Limited Membrane Sampling from West African Women with Uncomplicated Pregnancies.

Pathogens (Basel, Switzerland)
2025

Neglected tropical diseases elimination in Africa: lessons from regional control programmes.

Tropical medicine and health
2025

Comparison of three real-time polymerase chain reaction protocols for the diagnosis of imported schistosomiasis in a non-endemic setting.

Parasites &amp; vectors
2025

Development and validation of an explainable prediction model for schistosomiasis seropositivity: a population-based screening study in Hunan Province, China.

International journal for parasitology
2025

Non-parasite genome encoded virus-like RNAs reprogram the pathogenicity of human blood flukes.

Nature communications
2025

Systemic and capacity barriers to female genital schistosomiasis management among healthcare workers in Ghana: a mixed-method approach.

Tropical diseases, travel medicine and vaccines
2025

[Achievement of behavioral and metabolic factors control targets on atherosclerotic cardiovascular disease risk in patients with type 2 diabetes mellitus].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
2025

Pulmonary Hypertension Associated With Sickle Cell Disease and Schistosomiasis.

Pulmonary circulation
2025

Quantum-Mechanically Refined, Dynamics-Coupled, and AI-Augmented Elucidation of Epigenetic Inhibition: An In Silico Paradigm Targeting HDAC8 of Schistosoma mansoni.

Journal of tropical medicine
2025

Loss of vitamin C biosynthesis protects from the pathology of a parasitic infection.

Proceedings of the National Academy of Sciences of the United States of America
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Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

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Doença com base genética

Um médico geneticista pode ajudar no diagnóstico de Esquistossomose e no aconselhamento genético da família.

Vai consultar um especialista? Confirme o registro dele no conselho.
Conselhos e sociedades

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Perguntas frequentes

O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu

Respostas geradas por IA a partir das fontes citadas

A esquistossomose é causada por parasitas do gênero Schistosoma que vivem nos vasos sanguíneos. A liberação dos ovos do verme provoca reações inflamatórias agudas ou crônicas nos órgãos.

Referências

Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete

10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.

  1. ORPHA:1247
    Orphanet
  2. GARD:9687
    GARD (NIH)
  3. Q221159
    Wikidata

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Citar este verbete

Raras. (s.d.). Esquistossomose. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/esquistossomose

Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Esquistossomose
Compêndio · Raras BR

Esquistossomose

ORPHA:1247 · MONDO:0015254
Prevalência
<1 / 1 000 000
Herança
Not applicable
CID-10
B65.0 · Esquistossomose devida ao Schistosoma haematobium [esquistossomose urinária]
CID-11
Ensaios
12 ativos
Início
All ages
Prevalência
0.0 (Europe)
MedGen
UMLS
C0029827
Repurposing
3 candidatos
hycanthone — RNA synthesis inhibitor
niridazole — phosphofructokinase inhibitor
praziquantel — anthelmintic agent
Wikidata
Wikipedia
Papers 10a

📋 Origem dos dados

Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.

Doença rara (ontologia)
fonte: Orphanet
Identificador unificado
fonte: MONDO
Indexação biomédica
fonte: MeSH (NLM)
Dado público estruturado
fonte: Wikidata
Medicamentos aprovados FDA
fonte: FDA OpenFDA
Rara