Raras
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Síndromes hipereosinofílicos
ORPHA:168956CID-10 · D72.1DOENÇA RARA

A Síndrome Hipereosinofílica (HES) é um grupo de doenças raras e variadas. Ela é caracterizada por um aumento constante e significativo de um tipo de glóbulo branco chamado eosinófilo no sangue, e/ou pelo acúmulo desses eosinófilos nos tecidos e órgãos do corpo. Isso tudo está associado a uma grande variedade de sintomas que refletem os danos que os próprios eosinófilos causam a esses tecidos e órgãos.

Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

📋

A Síndrome Hipereosinofílica (HES) é um grupo de doenças raras e variadas. Ela é caracterizada por um aumento constante e significativo de um tipo de glóbulo branco chamado eosinófilo no sangue, e/ou pelo acúmulo desses eosinófilos nos tecidos e órgãos do corpo. Isso tudo está associado a uma grande variedade de sintomas que refletem os danos que os próprios eosinófilos causam a esses tecidos e órgãos.

Pesquisas ativas
10 ensaios
139 total registrados no ClinicalTrials.gov
Publicações científicas
2.499 artigos
Último publicado: 2026 Apr

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
Unknown
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Europe
Início
All ages
🏥
SUS: Sem cobertura SUSScore: 0%
CID-10: D72.1
Você se identifica com essa condição?
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Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🩸
Sangue
11 sintomas
🫃
Digestivo
11 sintomas
🫁
Pulmão
9 sintomas
❤️
Coração
6 sintomas
🧠
Neurológico
5 sintomas
🧬
Pele e cabelo
4 sintomas

+ 34 sintomas em outras categorias

Características mais comuns

Anormalidade inflamatória da pele
Dificuldades alimentares na infância
Arritmia supraventricular
Trombocitopenia
Edema do tornozelo
Hepatoesplenomegalia
88sintomas
Sem dados (88)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 88 características clínicas mais associadas, ordenadas por frequência.

Anormalidade inflamatória da peleInflammatory abnormality of the skin
Dificuldades alimentares na infânciaFeeding difficulties in infancy
Arritmia supraventricularSupraventricular arrhythmia
TrombocitopeniaThrombocytopenia
Edema do tornozeloAnkle swelling

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico2.499PubMed
Últimos 10 anos200publicações
Pico2025118 papers
Linha do tempo
2026Hoje · 2026🧪 1998Primeiro ensaio clínico📈 2025Ano de pico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

5 genes identificados com associação a esta condição. Padrão de herança: Not applicable, Unknown.

PDGFRAPlatelet-derived growth factor receptor alphaDisease-causing germline mutation(s) inAltamente restrito
FUNÇÃO

Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development and cephalic closure during embryonic development. Required for normal dev

LOCALIZAÇÃO

Cell membraneCell projection, ciliumGolgi apparatus

VIAS BIOLÓGICAS (1)
Signaling by PDGF
EXPRESSÃO TECIDUAL(Ubíquo)
Ovário
217.5 TPM
Fibroblastos
164.2 TPM
Cervix Endocervix
100.0 TPM
Fallopian Tube
89.1 TPM
Útero
77.5 TPM
OUTRAS DOENÇAS (8)
polyps, multiple and recurrent inflammatory fibroid, gastrointestinalidiopathic hypereosinophilic syndromeprimary hypereosinophilic syndromegastrointestinal stromal tumor
HGNC:8803UniProt:P16234
FGFR1Fibroblast growth factor receptor 1Candidate gene tested inAltamente restrito
FUNÇÃO

Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activati

LOCALIZAÇÃO

Cell membraneNucleusCytoplasm, cytosolCytoplasmic vesicle

VIAS BIOLÓGICAS (2)
Epithelial-Mesenchymal Transition (EMT) during gastrulationFormation of paraxial mesoderm
MECANISMO DE DOENÇA

Pfeiffer syndrome

A syndrome characterized by the association of craniosynostosis, broad and deviated thumbs and big toes, and partial syndactyly of the fingers and toes. Three subtypes are known: mild autosomal dominant form (type 1); cloverleaf skull, elbow ankylosis, early death, sporadic (type 2); craniosynostosis, early demise, sporadic (type 3).

EXPRESSÃO TECIDUAL(Ubíquo)
Aorta
144.8 TPM
Ovário
142.9 TPM
Artéria tibial
134.1 TPM
Fallopian Tube
122.3 TPM
Cérebro - Hemisfério cerebelar
122.0 TPM
OUTRAS DOENÇAS (20)
Hartsfield-Bixler-Demyer syndromeencephalocraniocutaneous lipomatosisosteoglophonic dysplasiaPfeiffer syndrome
HGNC:3688UniProt:P11362
ETV6Transcription factor ETV6Candidate gene tested inAltamente restrito
FUNÇÃO

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation

LOCALIZAÇÃO

Nucleus

VIAS BIOLÓGICAS (1)
Signaling by FLT3 fusion proteins
EXPRESSÃO TECIDUAL(Ubíquo)
Artéria tibial
45.0 TPM
Glândula salivar
42.7 TPM
Skin Sun Exposed Lower leg
35.5 TPM
Linfócitos
30.0 TPM
Aorta
29.4 TPM
OUTRAS DOENÇAS (9)
acute myeloid leukemiathrombocytopenia 5B-lymphoblastic leukemia/lymphoma with t(12;21)(p13.2;q22.1)obsolete autosomal thrombocytopenia with normal platelets
HGNC:3495UniProt:P41212
PDGFRBPlatelet-derived growth factor receptor betaCandidate gene tested inAltamente restrito
FUNÇÃO

Tyrosine-protein kinase that acts as a cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth

LOCALIZAÇÃO

Cell membraneCytoplasmic vesicleLysosome lumen

VIAS BIOLÓGICAS (1)
Signaling by PDGF
EXPRESSÃO TECIDUAL(Ubíquo)
Cervix Ectocervix
398.1 TPM
Cervix Endocervix
353.6 TPM
Artéria tibial
346.2 TPM
Tecido adiposo
303.2 TPM
Artéria coronária
277.8 TPM
OUTRAS DOENÇAS (10)
myofibromatosis, infantile, 1acroosteolysis-keloid-like lesions-premature aging syndromebasal ganglia calcification, idiopathic, 4ocular pterygium-digital keloid dysplasia syndrome
HGNC:8804UniProt:P09619
FIP1L1Pre-mRNA 3'-end-processing factor FIP1Candidate gene tested inAltamente restrito
FUNÇÃO

Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex

LOCALIZAÇÃO

Nucleus

VIAS BIOLÓGICAS (6)
mRNA 3'-end processingDengue Virus-Host InteractionsTransport of Mature mRNA Derived from an Intronless TranscriptProcessing of Intronless Pre-mRNAsRNA Polymerase II Transcription Termination
EXPRESSÃO TECIDUAL(Ubíquo)
Linfócitos
79.7 TPM
Testículo
78.1 TPM
Fibroblastos
70.5 TPM
Ovário
55.4 TPM
Cervix Endocervix
47.6 TPM
OUTRAS DOENÇAS (3)
acute promyelocytic leukemiaprimary hypereosinophilic syndromechronic eosinophilic leukemia
HGNC:19124UniProt:Q6UN15

Medicamentos aprovados (FDA)

1 medicamento encontrado nos registros da FDA americana.

💊 Imatinib Mesylate (IMATINIB MESYLATE)
Ver no DailyMed/FDA

Variantes genéticas (ClinVar)

852 variantes patogênicas registradas no ClinVar.

🧬 PDGFRA: NM_006206.6(PDGFRA):c.583G>C (p.Gly195Arg) ()
🧬 PDGFRA: NM_006206.6(PDGFRA):c.910A>G (p.Lys304Glu) ()
🧬 PDGFRA: NM_006206.6(PDGFRA):c.1951C>G (p.Leu651Val) ()
🧬 PDGFRA: NM_006206.6(PDGFRA):c.3169T>G (p.Ser1057Ala) ()
🧬 PDGFRA: NM_006206.6(PDGFRA):c.412G>A (p.Val138Ile) ()
Ver todas no ClinVar

Classificação de variantes (ClinVar)

Distribuição de 171 variantes classificadas pelo ClinVar.

17
137
17
Patogênica (9.9%)
VUS (80.1%)
Benigna (9.9%)
VARIANTES MAIS SIGNIFICATIVAS
PDGFRA: NM_006206.6(PDGFRA):c.932-13C>A [Conflicting classifications of pathogenicity]
PDGFRA: NM_006206.6(PDGFRA):c.*1778C>A [Conflicting classifications of pathogenicity]
PDGFRA: NM_006206.6(PDGFRA):c.2801A>G (p.Asn934Ser) [Uncertain significance]
PDGFRA: NM_006206.6(PDGFRA):c.1790G>T (p.Arg597Leu) [Uncertain significance]
PDGFRA: NM_006206.6(PDGFRA):c.799C>A (p.Pro267Thr) [Uncertain significance]

Vias biológicas (Reactome)

40 vias biológicas associadas aos genes desta condição.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
3Fase 34
2Fase 24
·Pré-clínico7
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 15 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Síndromes hipereosinofílicos

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

🟢 Recrutando agora

6 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

Outros ensaios clínicos

139 ensaios clínicos encontrados, 10 ativos.

Distribuição por fase
Ver todos no ClinicalTrials.gov
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Divulgue para pacientes e familiares que acompanham esta doença.
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Publicações mais relevantes

Timeline de publicações
934 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 934

#1

Long-term outcomes of autologous cell transplantation for patients with non-TAO autoimmune disease-related critical limb ischemia.

Cell transplantation2026

Autoimmune disease-related critical limb ischemia (AD-CLI) represents a significant portion of no-option critical limb ischemia (NO-CLI). Despite the demonstrated safety and efficacy of cell transplantation for NO-CLI, most studies focused on thromboangiitis obliterans (TAO). There remains a scarcity of reports on cell transplantation for AD-CLI induced by systemic lupus erythematosus (SLE), hypereosinophilic syndrome (HES), and so on. From May 2011 to May 2024, 22 patients with 36 ischemic limbs were enrolled. The primary outcome was amputation, whereas secondary outcomes included toe-brachial index (TBI), Wong-Baker Faces Pain Rating Scale (WBFPS), transcutaneous oxygen pressure (TcPO2), and so on. Among them, 8 had SLE, 11 had HES, and 3 had eosinophilic granulomatous polyangiitis (EGPA). During the follow-up, one EGPA patient died, two patients underwent major amputation, and five underwent minor amputation. The 2-year major and total amputation-free survival rates were 86.4% and 72.7%, respectively. Critical limb ischemia (CLI) relief was observed in 14 patients, with a 1-year cumulative CLI-free survival rate of 61.0%. Significant improvements were noted in postoperative TBI and WBFPS. Autologous cell transplantation showed satisfactory safety and efficacy outcomes for non-TAO AD-CLI patients. Validation of the conclusions awaits more evidence based on the long-term outcomes of a larger number of patients.

#2

Natural History of Patients With Histologically Proven Acute Eosinophilic Myocarditis.

Circulation2026 Mar 03

No large registries of patients with acute eosinophilic myocarditis (EM) are available. However, EM is perceived as a cardiac disease with high mortality, affecting mainly young and middle-aged adults according to small series and case reports. Awareness of the clinical presentation, associated systemic conditions, treatments, and outcomes of this uncommon condition is an unmet need. In this international, multicenter, retrospective cohort study, 53 centers screened 193 patients with histologically proven acute EM between 1992 and 2023. After the exclusion of patients with insufficient data (n=10), symptoms lasting >30 days (n=19), or histological diagnosis not confirmed after review (n=8), 156 patients were included. Median age at presentation was 48 years (first to third quartile, 34-59 years) with male predominance (67.3%), and only 2 were pediatric cases (≤16 years of age; 1.3%). The main signs and symptoms at presentation were dyspnea (75.6%), fever (61.3%), and chest pain (53.2%). Unexpectedly, peripheral eosinophilia was reported in only 57.4% of cases, with a median cell count of 630 eosinophils/μL. The median left ventricular ejection fraction at presentation was 32% (first to third quartile, 25%-48%). The disorders most frequently associated with EM were eosinophilic granulomatosis with polyangiitis (22.4% of cases) and hypersensitivity forms (14.1%). Idiopathic/undefined forms accounted for 44.9% of cases, and miscellaneous causes accounted for 18.6%. In-hospital death or need for heart transplantation (HTx) occurred in 23 patients (14.7%; 22 deaths and 1 HTx), despite 43.6% being treated with temporary mechanical circulatory support and 92.9% being treated with immunosuppressive agents. Estimated rates of death or HTx at 1 and 3 years were 19.0% and 23.8%. Increased age, decreased left ventricular ejection fraction on admission, and no immunosuppressive therapy during hospitalization were independent predictors of death or HTx. A nonsignificant higher occurrence of deaths or HTx was observed in the hypersensitivity form (46.1%) compared with the eosinophilic granulomatosis with polyangiitis-associated form (13.1%) at 3 years (P=0.15). Acute EM can often present without peripheral eosinophilia, and rates of in-hospital and midterm mortality or HTx are high. Endomyocardial biopsy is required to reach the final diagnosis of EM because relying on peripheral eosinophilia can lead to missing diagnosis. In-hospital immunosuppression is associated with HTx-free survival, although tailored immunosuppressive therapies are needed to improve outcomes. URL: https://www.clinicaltrials.gov; Unique identifier: NCT06447935.

#3

Idiopathic Hypereosinophilic Syndrome Presenting as Acute Encephalopathy Secondary to Watershed Ischemic Stroke.

Annals of Indian Academy of Neurology2026 Mar 05
#4

Idiopathic Hypereosinophilic Syndrome in a Child- Rare Disease with Fulminant Clinical Course.

Indian journal of hematology &amp; blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion2026 Mar
#5

Hypereosinophilic syndrome presenting as pleural and pericardial effusion in a Pediatric patient: a rare case report.

Oxford medical case reports2026 Mar

Hypereosinophilic syndrome is a rare disorder in children, particularly when presenting with simultaneous pleural and pericardial effusions. We report the case of a 4-year-old girl who presented with fever, cough, shortness of breath, and chest pain. Clinical evaluation revealed bilateral pleural effusion and later pericardial effusion with impending tamponade. Laboratory investigations showed marked hypereosinophilia, while infectious, rheumatologic, and malignant causes were excluded. Bone marrow findings confirmed eosinophilic predominance without atypia. The patient underwent pericardiocentesis and was treated with corticosteroids, resulting in clinical improvement and normalization of eosinophil counts. On follow-up, she remained asymptomatic with resolution of effusions. This case underscores the importance of considering HES as a differential diagnosis in pediatric patients with eosinophilic effusions and highlights the role of early recognition and corticosteroid therapy in preventing life-threatening complications.

Publicações recentes

Ver todas no PubMed

📚 EuropePMC1.556 artigos no totalmostrando 197

2026

Hypereosinophilic syndrome presenting as pleural and pericardial effusion in a Pediatric patient: a rare case report.

Oxford medical case reports
2026

Possible Involvement of Eosinophil ETosis in Hepatic Injury Associated with Hypereosinophilic Syndrome.

Modern rheumatology case reports
2026

Redefining Hematology Referral Thresholds for Eosinophilia.

European journal of haematology
2026

Molecular Pathogenesis and Targeted Therapies for Myeloproliferative Hypereosinophilic Neoplasms.

Current hematologic malignancy reports
2026

Biologics Use in Eosinophilic Lung Disease: Controversies and Consensus.

The journal of allergy and clinical immunology. In practice
2026

Differential Diagnosis of Eosinophilic Lung Diseases.

The journal of allergy and clinical immunology. In practice
2026

Idiopathic Hypereosinophilic Syndrome Presenting as Acute Encephalopathy Secondary to Watershed Ischemic Stroke.

Annals of Indian Academy of Neurology
2026

Long-term outcomes of autologous cell transplantation for patients with non-TAO autoimmune disease-related critical limb ischemia.

Cell transplantation
2026

Loss of NF-κB-inducing kinase (NIK) affects eosinophilopoiesis in a murine model of Hypereosinophilic syndrome.

Journal of leukocyte biology
2026

Acute hemiplegia as initial presentation in FIP1L1-PDGFRA-rearranged myeloid neoplasm with eosinophilia: a case report.

Frontiers in oncology
2026

[Incidental finding of negative T waves: a case of endomyocardial fibrosis].

Giornale italiano di cardiologia (2006)
2026

Long Term Outcomes in Patients With Non-Infectious Mixed Cryoglobulinemic Vasculitis.

American journal of hematology
2026

Idiopathic Hypereosinophilic Syndrome in a Child- Rare Disease with Fulminant Clinical Course.

Indian journal of hematology &amp; blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
2026

Case Report of a Lymphocytic Variant Hypereosinophilic Syndrome Mimicking T-Cell Lymphoma: A Diagnostic Challenge and Therapeutic Response to Mepolizumab.

The Australasian journal of dermatology
2026

Laboratory Aspects and Diagnostic Challenges in a Case of Hypereosinophilic Syndrome.

Cureus
2026

Ischemic stroke complicated by intracerebral hemorrhage in patients with hypereosinophilic syndrome: a case series.

Therapeutic advances in neurological disorders
2026

IL-5 CAR-T cell therapy induces effective remission in hypereosinophilic disorders.

Journal of hematology &amp; oncology
2026

Novel Diagnostic Approaches for Eosinophilic Lung Diseases.

The journal of allergy and clinical immunology. In practice
2026

Natural History of Patients With Histologically Proven Acute Eosinophilic Myocarditis.

Circulation
2026

Catastrophic antiphospholipid syndrome with eosinophilia mimicking hypereosinophilic syndromes with disseminated intravascular coagulation: a case report.

Journal of medical case reports
2025

Fatal Eosinophilic Pulmonary Vasculitis in a Neonate - The First Documented Case in the English Literature.

Annals of clinical and laboratory science
2025

Case Report: Triple autoimmune overlap: rheumatoid arthritis, systemic lupus erythematosus, and hypereosinophilic asthma with systemic manifestations.

Frontiers in immunology
2025

From hypereosinophilia to hypereosinophilic syndrome: real-world application of a two-tailed approach for HES diagnosis.

Frontiers in immunology
2025

Fulminant Idiopathic Hypereosinophilic Syndrome Presenting with Cardiac, Neurologic and Haematologic Involvement.

European journal of case reports in internal medicine
2026

Severe mitral regurgitation in the course of hypereosinophilic syndrome.

Polish archives of internal medicine
2025

The value of left ventricular and left atrial strains in eosinophilic myocarditis and hypereosinophilic syndrome.

Cardiovascular diagnosis and therapy
2026

Real-world outcomes after anti-IL-5/anti-IL-5Rα treatment for hypereosinophilic syndrome: Systematic literature review.

The journal of allergy and clinical immunology. Global
2025

Genetic mutations in lymphocytic variant of hypereosinophilic syndrome: study of five siblings.

Frontiers in medicine
2025

Evaluation and differential diagnosis of eosinophilia: A tertiary allergy center experience.

Tuberkuloz ve toraks
2026

A Rapid Drug-Induced Granulomatous Dermatitis to Amlodipine.

The American journal of cardiology
2025

Benralizumab: Bringing winds of change to eosinophil-associated diseases.

The World Allergy Organization journal
2025

ANCA-Negative Eosinophilic Granulomatosis With Polyangiitis Presenting With Duodenal Stenosis: A Case Report.

The American journal of case reports
2025

Rapid Improvement of Refractory Cutaneous Hypereosinophilic Syndrome with Abrocitinib Plus Methylprednisolone: A Case Report.

Clinical, cosmetic and investigational dermatology
2026

Hypereosinophilia: Clinical Presentations and Diagnostic Distinction between Syndromic and Reactive Entities - A Case Series.

Romanian journal of internal medicine = Revue roumaine de medecine interne
2025

Refractory erythroderma in idiopathic hypereosinophilic syndrome: A case treated with mepolizumab and abrocitinib.

SAGE open medical case reports
2026

From bone marrow to the heart: a case report of cardiac involvement in myeloproliferative-associated hypereosinophilic syndrome.

Future cardiology
2025

Loffler endocarditis as an initial manifestation of lung adenocarcinoma: A case report.

Medicine
2025

Acute multisystemic thromboembolism manifesting as cerebral infarction, myocardial injury, and quadriparesis: a novel triad of idiopathic hypereosinophilic syndrome.

Frontiers in medicine
2025

Toward Better Patient-Centered Care of Hypereosinophilic Syndrome Using Novel Patient-Reported Outcome Measure Tool.

The journal of allergy and clinical immunology. In practice
2025

Steroid resistant, osimertinib induced hypereosinophilic syndrome (HES) treated with Benralizumab in a patient with metastatic adenocarcinoma of lung.

Respiratory medicine case reports
2025

Biologic Therapy for Chronic Rhinosinusitis with Nasal Polyps: Case Analysis and Proposal of a Qualification Scheme.

Otolaryngologia polska = The Polish otolaryngology
2025

Lymphocytic Hypereosinophilic Syndrome Evolving to Fatal Hemophagocytic Lymphohistiocytosis: Cytokine Signatures.

Clinical laboratory
2026

Ischemic Stroke in Hypereosinophilic Syndrome: A Clinicopathologic Study of Two Cases.

Neuropathology : official journal of the Japanese Society of Neuropathology
2025

Mepolizumab for hypereosinophilic syndrome: effectiveness and safety from real-world evidence.

Frontiers in immunology
2026

Prediction model to identify patients with hypereosinophilic syndrome using real-world data.

The journal of allergy and clinical immunology. Global
2025

Hypereosinophilic syndrome with pulmonary and hepatic involvement mimicking autoimmune disease.

Oxford medical case reports
2026

Clinical Utility of 18 F-FDG PET/CT in Patients With Hypereosinophilia : An 11-year Single-center Experience.

Clinical nuclear medicine
2026

Endomyocardial Fibrosis Associated With Hypereosinophilic Syndrome: Diagnostic and Management Insights From a Case Report.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography &amp; Interventions
2026

Mepolizumab improves health-related quality of life in patients with hypereosinophilic syndrome.

European journal of internal medicine
2026

The Clinical Burden of Hypereosinophilic Syndrome in a Large United States Cohort.

The journal of allergy and clinical immunology. In practice
2025

Loeffler endocarditis in hypereosinophilic syndrome, the paradox of absent peripheral eosinophilia: a case report.

European heart journal. Case reports
2025

Idiopathic hypereosinophilic syndrome complicated by computed tomography-negative cerebral infarction, strangulated intestinal obstruction, and hepatic portal venous gas: a case report of multi-system involvement.

Quantitative imaging in medicine and surgery
2025

Non-atherosclerotic myocardial infarction in hypereosinophilic syndrome: emerging insights and therapeutic approaches.

Heart (British Cardiac Society)
2025

Cellular profiling identifies targetable T cell phenotypes in lymphocytic variant hypereosinophilic syndrome.

The Journal of clinical investigation
2026

Parasitic-induced Loeffler's syndrome: A systematic review based on clinical reports.

Journal of infection and public health
2025

[Clinical analysis of six eosinophilia cases with Löeffler endocarditis as the main clinical feature].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
2025

Idiopathic hypereosinophilic syndrome associated with multivessel coronary artery ectasia: a case report.

The Pan African medical journal
2025

Panuveitis Associated With Idiopathic Hypereosinophilic Syndrome.

Journal of vitreoretinal diseases
2025

Eosinophilic Cardiac Involvement.

The journal of allergy and clinical immunology. In practice
2025

Eosinophilic Myocarditis Treated with IL-5 Blockade: An Integrated Case Report and Literature Review.

Journal of clinical medicine
2026

Pediatric Severe Eosinophilia: Etiological Spectrum, Diagnostic Algorithm, and Case-Based Insights From a Tertiary Care Center.

International journal of laboratory hematology
2025

Idiopathic hypereosinophilic syndrome: Potential pathologic somatic gene variants identified by exome sequencing.

The journal of allergy and clinical immunology. Global
2025

The role of eosinophils and their activation state in hypereosinophilia-associated heart disease.

Frontiers in immunology
2025

Hypereosinophilic Syndrome Presenting as Coronary Artery Spasm and ST-Segment Elevation Myocardial Infarction.

JACC. Case reports
2025

Idiopathic hypereosinophilic syndrome in a female Sprague Dawley rat.

Laboratory animals
2025

Organ-Restricted Hypereosinophilic Syndrome: A Case of Recurrent Hypereosinophilic Myopericarditis.

JACC. Case reports
2025

Development and Validation of the FIP Score for the Screening of FIP1L1::PDGFRA-Associated Hypereosinophilic Syndrome.

The journal of allergy and clinical immunology. In practice
2025

Development of a Patient-Reported Outcome Measure for Hypereosinophilic Syndrome.

The journal of allergy and clinical immunology. In practice
2025

The hypereosinophilia dilemma: what's beyond cardiac involvement?

Romanian journal of internal medicine = Revue roumaine de medecine interne
2025

A Clinical Conundrum in Patients With a Common Clinical Spectrum but Rare Differentials: Hyper-Immunoglobulin E Syndrome and Idiopathic Eosinophilia.

Cureus
2025

Eosinophilic ascites and eosinophilic gastrointestinal diseases.

European annals of allergy and clinical immunology
2025

Paradoxical Use of Benralizumab in Reactive Hypereosinophilia from Toxocariasis and Tuberculosis Co-Infection-Case Report and Literature Review.

International journal of molecular sciences
2025

Idiopathic Hypereosinophilic Syndrome Presenting As Eosinophilic Ascites and Pleural Effusion in an Elderly Male: A Rare Clinical Manifestation.

Cureus
2025

[Biologicals in Type-2-Inflammation - from Chronic Rhinosinusitis with Nasal Polyps to Hypereosinophilic Syndrome].

Laryngo- rhino- otologie
2025

Benralizumab in a Patient With Refractory Eosinophilic Endocarditis.

Journal of medical cases
2025

A case report of fulminant eosinophilic myo-pericarditis related to checkpoint inhibitors complicated by acute heart failure and cardiac tamponade.

European heart journal. Case reports
2025

[Efficacy and survival outcomes of patients with lymphocytic variant hypereosinophilic syndrome].

Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
2025

Eosinophilic lung disease with a tumour lysis-like syndrome.

BMJ case reports
2025

Case Report: Idiopathic hypereosinophilic syndrome presenting with gastrointestinal involvement mimicking IBD: a diagnostic challenge.

Frontiers in medicine
2025

[A Case of Idiopathic Hypereosinophilic Syndrome Treated with Mepolizumab].

Acta medica portuguesa
2025

Hypereosinophilic Syndrome in a Patient With Cystic Fibrosis: A Rare Case of Cardiac Involvement and Response to Mepolizumab.

Cureus
2025

Development and implementation of Phleos, a web-based tool for the data collection on Hypereosinophilic syndrome: the Italian Network on HES (INHES) study protocol.

Frontiers in immunology
2025

A Rare Presentation of Bilateral Foot Drop in Anti-neutrophil Cytoplasmic Antibody (ANCA)-Negative Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss Syndrome): A Diagnostic Challenge.

Cureus
2025

Hypereosinophilic syndrome with elevated IgG4 and T-cell clonality: A report of two cases.

Open life sciences
2025

Diagnostic and therapeutic challenges in colonic eosinophilic abscess complicated with eosinophilic vasculitis: a case report and literature review.

Frontiers in medicine
2025

Clinical and immunological biomarkers in hypereosinophilic syndrome: the second step after diagnostic algorithms.

Frontiers in medicine
2025

An Uncommon Case of Non-Specific Interstitial Pneumonia (NSIP) Associated With Idiopathic Hypereosinophilic Syndrome (HES) Reversed by Mepolizumab.

Respirology case reports
2025

Primary care physicians play a crucial role in diagnosing and managing rare eosinophilic diseases: HES and EGPA.

Frontiers in medicine
2025

Diagnosis of Loeffler Endocarditis in a Patient with a Cerebrovascular Event.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
2025

Lymphocytic Variant Hypereosinophilic Syndrome With Extensive Mucocutaneous Involvement Successfully Treated With Ruxolitinib.

American journal of hematology
2025

Hypereosinophilic syndrome presented with portal, superior mesenteric, and splenic vein thromboses in a child.

Pediatrics international : official journal of the Japan Pediatric Society
2025

Hypereosinophilic Syndrome With Sialadenitis and Orbital Inflammation: A Case Report.

Journal of investigational allergology &amp; clinical immunology
2025

High Disease Burden and Oral Corticosteroid Use in Patients with Hypereosinophilic Syndrome and Eosinophilic Granulomatosis with Polyangiitis: Country-Level Insights into Real-World Management in Europe.

Journal of clinical medicine
2025

Optimizing diagnostic and management pathways for patients with eosinophilia of unknown origin: a multidisciplinary protocol for urgent and non-urgent evaluation.

Frontiers in medicine
2025

Reversible Dementia With Hypereosinophilia: An Intricate Connection.

Cureus
2025

Th2-High Severe Asthma with Hypereosinophilia in the Spectrum of Type 2 Inflammatory Diseases.

International journal of molecular sciences
2025

Steroid-sparing benefits of biologic use in hypereosinophilic syndrome and substantial disease burden across subtypes.

Frontiers in allergy
2025

Coronary Artery Spasm as a Rare Manifestation of Hypereosinophilic Syndrome: A Case Report.

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography &amp; Interventions
2025

Hypereosinophilic Syndrome Presenting with Digestive Symptoms in Pediatric Patients: A Portuguese Tertiary Hospital Case Series.

GE Portuguese journal of gastroenterology
2025

Four challenging cases of eosinophilic endocarditis or myocarditis with literature review.

Journal of cardiothoracic surgery
2025

Tracking Public Interest in Rare Diseases and Eosinophilic Disorders in Germany: Web Search Analysis.

JMIR infodemiology
2025

Hypereosinophilia in Children.

Current allergy and asthma reports
2025

Loeffler Endocarditis with Antineutrophil Cytoplasmic Antibody-associated Vasculitis after COVID-19 Vaccination.

Internal medicine (Tokyo, Japan)
2025

Hypereosinophilia: clinical and therapeutic approach in 2025.

Current opinion in allergy and clinical immunology
2025

Loeffler endocarditis revealing chronic eosinophilic leukaemia with FIP1L1-PDGFRA rearrangement: a case report.

European heart journal. Case reports
2025

Benralizumab for acute thromboembolism in hypereosinophilic syndrome: a case report.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology
2025

Eosinophilia and gastrointestinal symptoms in Immunosuppression: a classic but overlooked diagnosis.

Revista espanola de enfermedades digestivas
2025

Expansion of multiple CD4+ T-cell lineages in lymphocytic variant hypereosinophilic syndrome.

The Journal of allergy and clinical immunology
2025

Complete hematological response with imatinib mesylate in a corticosteroid refractory idiopathic hypereosinophilic syndrome in person living with HIV: A case report.

International journal of STD &amp; AIDS
2025

Eosinophilic complications during dupilumab therapy for type 2 diseases: a systematic review.

Rhinology
2025

Improving patient outcomes: Mepolizumab's impact in IL-5-mediated diseases.

Lung India : official organ of Indian Chest Society
2025

Biologic Agents in Idiopathic Hypereosinophilic Syndrome.

Pharmaceuticals (Basel, Switzerland)
2025

A newly identified pathology of episodic angioedema with hypereosinophilia (Gleich syndrome) revealed by nultiomics analysis.

The journal of allergy and clinical immunology. Global
2025

Unexpected hypereosinophilia after Sinopharm vaccination: a case report.

BMC infectious diseases
2025

Inflammation and INOCA: Can Fat Attenuation Indexing by Coronary CT Angiography Help Identify Coronary Inflammation?

JACC. Case reports
2025

Hypereosinophilic syndrome with Löffler endocarditis in a patient with Rhupus syndrome.

Clinical and experimental rheumatology
2025

When Eosinophils Speak: A Case of Strongyloides stercoralis Infection.

Indian journal of hematology &amp; blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion
2025

Insights from comparison of serum IgG4 between T2-eosinophilic asthma and eosinophilic granulomatosis with polyangiitis/idiopathic hypereosinophilic syndrome.

Clinical and experimental rheumatology
2025

11-Year-Old Boy With B-ALL-Induced Hypereosinophilic Syndrome Presenting as Acute Encephalopathy.

Pediatrics
2025

Lymphocytic Variant Hypereosinophilic Syndrome: Case Series From a Tertiary Referral Center in Canada.

EJHaem
2025

Eosinophilic granulomatosis with polyangiitis: Patient profiles from a large US allergy practice.

The journal of allergy and clinical immunology. Global
2025

Long-Term Efficacy and Safety of Benralizumab Treatment for PDGFRA-Negative Hypereosinophilic Syndrome.

The journal of allergy and clinical immunology. In practice
2025

Clonal eosinophilia with exclusive pulmonary involvement driven by PDGFRA rearrangement treated with imatinib: A case report.

Leukemia research reports
2025

Highlights from the plenary session: eosinophilic granulomatosis with polyangiitis and hypereosinophilic syndrome.

Rheumatology (Oxford, England)
2025

Hypereosinophilic Syndrome in a Patient With Complex Pulmonary Hypertension and Sjogren's Syndrome: A Case Report.

Cureus
2024

More Than Just Stool: Hypereosinophilic Syndrome Presenting as Persistent Diarrhea in a Patient With Ulcerative Colitis.

Journal of Brown hospital medicine
2025

Efficacy of anti-interleukin 5 therapy in hypereosinophilic syndrome: An updated systematic review and meta-analysis.

Allergy and asthma proceedings
2025

Clinical Management of Persistent Hypereosinophilia.

European journal of haematology
2025

T-cell lymphoproliferative disorder with a STAT3 mutation causing a lymphocytic variant of hypereosinophilic-like syndrome without eosinophilia.

Journal of hematopathology
2025

Double Trouble: Coronary Aneurysm and Löffler Endocarditis in Hypereosinophilic Syndrome.

Circulation. Heart failure
2025

Refractory Idiopathic Hypereosinophilic Syndrome Presenting with Myocarditis and Responding to Imatinib: A Case Report.

Saudi journal of medicine &amp; medical sciences
2025

Novel ETV6::RAPGEF6 fusion gene in chronic eosinophilic leukemia: compiling evidence on the role of IL3 overexpression in tumorigenesis.

Annals of hematology
2025

68 Ga-FAPI PET/CT in a Patient With Multiple Aneurysms Due to Idiopathic Hypereosinophilic Syndrome.

Clinical nuclear medicine
2025

NF-κB-inducing kinase (NIK): an emerging therapeutic target in human disease.

Expert opinion on therapeutic targets
2025

Thrombotic prosthetic valve dysfunction requiring valve re-replacement after mitral valve replacement for caseous calcification with hypereosinophilic syndrome: a case report.

European heart journal. Case reports
2024

Eosinophils: old cells, new directions.

Frontiers in medicine
2024

Idiopathic Hypereosinophilic Syndrome With Cutaneous Manifestations: A Case Report.

Cureus
2025

Pulmonary Arterial Hypertension Associated With Idiopathic Hypereosinophilic Syndrome: Importance of Eosinophilia Control With Steroid Therapy.

CJC open
2025

Myocarditis with neurological and dermatological involvement in idiopathic Hypereosinophilic syndrome: Case report.

Radiology case reports
2024

Wells' Syndrome Associated With Idiopathic Hypereosinophilic Syndrome in a Child: A Case Report.

Cureus
2025

Single-center off-label benralizumab use for refractory hypereosinophilic syndrome demonstrates satisfactory safety and efficacy.

EJHaem
2025

Eosinophilic Myocarditis: A Concise Review.

Current cardiology reports
2025

Cryptic to conventional cytogenetics: Philadelphia-like ALL presenting with hypereosinophilia.

BMJ case reports
2025

A real-world study to evaluate effectiveness of mepolizumab in treating severe asthma in Taiwan (REMIT).

Therapeutic advances in respiratory disease
2025

Hypereosinophilic Syndrome Complicated by Eosinophilic Myocarditis: Embolic Stroke or Eosinophilic Stroke? A Case Report.

Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
2024

The Cleveland Clinic experience of eosinophilic myocarditis in the setting of hypereosinophilic syndrome: demographics, cardiac imaging, and outcomes.

Cardiovascular diagnosis and therapy
2025

Mepolizumab in patients with lymphoid-variant hypereosinophilic syndrome: A multicenter prospective study.

The Journal of allergy and clinical immunology
2024

A Rare Case of Eosinophilic Myocarditis Described With 18F-FDG PET/CT.

Clinical nuclear medicine
2024

Acute Border Zone Infarcts in Hypereosinophilic Syndrome.

Kansas journal of medicine
2025

Hypereosinophilia and Hypereosinophilic Syndromes: First Findings From a Nationwide Multicenter Cohort.

Allergy
2024

Case Report: Loeffler endocarditis as a cause of left ventricular thrombosis in young women: a case study and literature review.

Frontiers in cardiovascular medicine
2024

Vectorized Human Antibody-Mediated Anti-Eosinophil Gene Therapy.

Human gene therapy
2024

[The evaluation of a patient with eosinophilia].

Nederlands tijdschrift voor geneeskunde
2024

Fulminant eosinophilic myocarditis and refractory ventricular arrhythmias requiring mechanical circulatory support: a case report.

European heart journal. Case reports
2024

Hyper eosinophilic diseases - diagnosis and therapeutic approach - practical position of the Polish working group.

Otolaryngologia polska = The Polish otolaryngology
2024

Cardiac Abnormalities in Hypereosinophilic Syndromes.

Arquivos brasileiros de cardiologia
2025

Chronic eosinophilic leukaemia-Not otherwise specified: Clinical features, genomic insight and therapeutic strategies.

British journal of haematology
2024

A Storm of Polyserositis: Unravelling Multisystem Effusions in Hypereosinophilic Syndrome.

Cureus
2024

Management of multiple valve replacement operations for a young patient with hypereosinophilic syndrome and valvular heart disease: a case report.

General thoracic and cardiovascular surgery cases
2024

Unexpected Multiple Gastrointestinal Cancers in a Patient with Chronic Eosinophilia: A Case Report.

Journal of gastrointestinal cancer
2025

Dupilumab Use in Patients With Hypereosinophilic Syndromes: A Multicenter Case Series and Review of the Literature.

The journal of allergy and clinical immunology. In practice
2024

[Hypereosinophilic syndrome, case report and diagnostic approach].

Revista medica del Instituto Mexicano del Seguro Social
2024

Non-episodic angioedema with eosinophilia as a differential diagnosis of eosinophilia in young females.

The World Allergy Organization journal
2024

Multiple Cerebral Infarcts and Encephalopathy as the First Clinical Manifestations of Hypereosinophilic Syndrome: A Case Report and Narrative Review.

Pulse (Basel, Switzerland)
2024

Imatinib is effective in some PDGFRA/B-negative hypereosinophilic syndromes: A step closer to unveiling underlying mechanisms.

British journal of haematology
2024

AGA Clinical Practice Update on Esophageal Dysfunction Due to Disordered Immunity and Infection: Expert Review.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
2024

Mepolizumab-responsive recurrent eosinophilic eruption without peripheral eosinophilia.

JAAD case reports
2025

A rare case of PDGFRA-positive chronic eosinophilic leukemia.

Indian journal of pathology &amp; microbiology
2024

An Uncommon Cause of Acute Heart Failure: A Case Report.

Cureus
2024

Eosinophilic myocarditis: a diagnostic challenge and treatment dilemma-a case report.

European heart journal. Case reports
2024

Phase II trial of imatinib mesylate in patients with PDGFRA/B-negative hypereosinophilic syndrome.

British journal of haematology
2024

Biologics in Hypereosinophilic Syndrome and Eosinophilic Granulomatosis with Polyangiitis.

Immunology and allergy clinics of North America
2024

Rapid identification of primary atopic disorders (PAD) by a clinical landmark-guided, upfront use of genomic sequencing.

Allergologie select
2024

Severe Acute Respiratory Distress in a Child with Hypereosinophilic Syndrome: A Case Report.

JNMA; journal of the Nepal Medical Association
2024

A hybrid case of eosinophilic folliculitis and eosinophilic cellulitis associated with hypereosinophilic syndrome.

Skin health and disease
2024

A Challenging Case of Idiopathic Hypereosinophilic Syndrome: An Itching in the Brain.

Cureus
2024

Incessant Ventricular Tachycardia: An Atypical Presentation of Chronic Eosinophilic Leukemia.

JACC. Case reports
2025

Possible Association of CD3+CD4-CD8- Phenotype of T-Cell Lymphoma with Peripheral Blood Eosinophilia.

International archives of allergy and immunology
2024

Beyond the norm: Illuminating eosinophilic ascites with 2 rare and intriguing cases.

Radiology case reports
2024

Successful novel use of dupilumab for gastrointestinal involvement of idiopathic hypereosinophilic syndrome: case report and review of the literature.

Clinical journal of gastroenterology
2024

Probable idiopathic hypereosinophilic syndrome: A case report of severe multi-organ eosinophilic involvement in a young male presenting with heart failure.

SAGE open medical case reports
2024

Chronic cough, wheezing, and atelectasis following COVID-19: A case report on the diagnostic evaluation and effective treatment of a life-threatening asthma mimicker.

Pediatric pulmonology
2024

Idiopathic hypereosinophilic syndromes and rare dysimmune conditions associated with hyper-eosinophilia in practice: An innovative multidisciplinary approach.

The World Allergy Organization journal
2024

Diagnosis of rare Loffler endocarditis by cardiac ultrasound: a case report and literature review.

Medical ultrasonography
2024

Endomyocardial involvement in asymptomatic Latin American migrants with eosinophilia related to helminth infection: A pilot study.

PLoS neglected tropical diseases
2024

A case report of right-sided heart failure secondary to JAK2-mutation Loeffler endocarditis.

ESC heart failure
2025

Eosinophilic Gastroenteritis with Ascites, Elevated Serum IgG4, and Hypereosinophilic Syndrome: A Manifestation of IgG4-related Disease?

Internal medicine (Tokyo, Japan)
2024

A unique case of paraneoplastic lymphomatoid Papuloerythroderma of Ofuji with atypical clinical features.

JAAD case reports
2024

Managing Patients with Hypereosinophilic Syndrome: A Statement from the Italian Society of Allergy, Asthma, and Clinical Immunology (SIAAIC).

Cells
2024

A case report of Löffler's endocarditis with right ventricular outflow obstruction in idiopathic hypereosinophilic syndrome: timely surgical intervention is crucial.

European heart journal. Case reports
2024

Value and limitations of targeted next-generation sequencing in idiopathic hypereosinophilia: an integrative diagnostic tool in challenging cases.

Clinical and experimental medicine
2024

Radioclinical Profile of Eosinophilic Lung: A Case Series.

Cureus
2024

The three stages of eosinophilic cardiac damage: A series of case reports.

Journal of cardiology cases
2024

Tezepelumab for refractory eosinophilic granulomatosis with polyangiitis-related asthma.

Respiratory research
2024

Chronic eosinophilic leukemia with a novel JAK1 mutation responds well to the JAK1/2 inhibitor ruxolitinib.

Blood
2024

Hypereosinophilic syndrome response to mepolizumab in the setting of a compassionate use program.

Journal of leukocyte biology
2024

Hypereosinophilia and Left Ventricular Thrombus: A Case Report and Literature Review.

Cureus
Ver todos os 1.556 no EuropePMC

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Doenças relacionadas

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Referências e fontes

Bases de dados externas citadas neste artigo

Publicações científicas

Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.

  1. Long-term outcomes of autologous cell transplantation for patients with non-TAO autoimmune disease-related critical limb ischemia.
    Cell transplantation· 2026· PMID 41776386mais citado
  2. Natural History of Patients With Histologically Proven Acute Eosinophilic Myocarditis.
    Circulation· 2026· PMID 41645905mais citado
  3. Idiopathic Hypereosinophilic Syndrome Presenting as Acute Encephalopathy Secondary to Watershed Ischemic Stroke.
    Annals of Indian Academy of Neurology· 2026· PMID 41784094mais citado
  4. Idiopathic Hypereosinophilic Syndrome in a Child- Rare Disease with Fulminant Clinical Course.
    Indian journal of hematology &amp; blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion· 2026· PMID 41728149mais citado
  5. Hypereosinophilic syndrome presenting as pleural and pericardial effusion in a Pediatric patient: a rare case report.
    Oxford medical case reports· 2026· PMID 41878590mais citado
  6. Coronary vasospasm in a patient with RUNX1 mutation in eosinophilic leukemia and hypereosinophilic syndrome: A case report.
    J Cardiol Cases· 2026· PMID 41994071recente
  7. Case Report: Hypereosinophilic syndrome misdiagnosed as atopic dermatitis due to refractory pruritic rash masking peripheral neuropathy.
    Front Med (Lausanne)· 2026· PMID 41958569recente
  8. Idiopathic Hypereosinophilic Syndrome in a Patient with End-Stage Renal Disease.
    Clin Lab· 2026· PMID 41945721recente
  9. Benralizumab versus placebo for hypereosinophilic syndrome: a randomized, placebo-controlled phase 3 trial.
    Nat Med· 2026· PMID 41917160recente
  10. Eosinophilic Organ Complications Associated with Dupilumab Therapy - Narrative Review and Current Evidence.
    J Asthma Allergy· 2026· PMID 41913773recente

Bases de dados e fontes oficiais

Identificadores e referências canônicas usadas para montar este verbete.

  1. ORPHA:168956(Orphanet)
  2. MONDO:0015691(MONDO)
  3. GARD:2804(GARD (NIH))
  4. Variantes catalogadas(ClinVar)
  5. Busca completa no PubMed(PubMed)
  6. Artigo Wikipedia(Wikipedia)
  7. Q2551272(Wikidata)

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Síndromes hipereosinofílicos
Compêndio · Raras BR

Síndromes hipereosinofílicos

ORPHA:168956 · MONDO:0015691
Prevalência
Unknown
Herança
Not applicable, Unknown
CID-10
D72.1 · Eosinofilia
Ensaios
10 ativos
Início
All ages
Prevalência
0.0 (Europe)
MedGen
UMLS
C0206142
Repurposing
1 candidato
imatinibBcr-Abl kinase inhibitor|KIT inhibitor|PDGFR tyrosine kinase receptor inhibitor
EuropePMC
Wikidata
Wikipedia
Papers 10a
DiscussaoAtiva

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