A Fascite Eosinofílica é uma doença rara do tecido conjuntivo (que dá suporte ao corpo) caracterizada pela inflamação e espessamento da fáscia (o tecido que envolve os músculos), geralmente associada a um aumento de um tipo de célula de defesa do sangue chamada eosinófilo. Ela geralmente se manifesta em adultos com inchaço simétrico e doloroso, principalmente nos braços e nas pernas, que com o tempo se tornam endurecidos. Cansaço, endurecimento da pele que pode causar limitações, inflamação dos músculos (miosites) e inflamação nas articulações (artrite) também podem ser observados.
Introdução
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A **fasceíte eosinofílica**, também chamada de síndrome Shulman, é uma doença rara que causa inflamação e endurecimento da fáscia, o tecido fibroso que protege os músculos. Geralmente manifesta-se em adultos provocando inchaço doloroso nos braços e nas pernas, além de cansaço excessivo e dores nas articulações. Nos exames de laboratório, é muito frequente encontrar um aumento de eosinófilos, que são células de defesa presentes no sangue. No Brasil, a doença não conta com um protocolo próprio ou medicamentos específicos dispensados pelo SUS por meio de PCDT, mas o acompanhamento é realizado pelos serviços de saúde de referência.
A Fascite Eosinofílica é uma doença rara do tecido conjuntivo (que dá suporte ao corpo) caracterizada pela inflamação e espessamento da fáscia (o tecido que envolve os músculos), geralmente associada a um aumento de um tipo de célula de defesa do sangue chamada eosinófilo. Ela geralmente se manifesta em adultos com inchaço simétrico e doloroso, principalmente nos braços e nas pernas, que com o tempo se tornam endurecidos. Cansaço, endurecimento da pele que pode causar limitações, inflamação dos músculos (miosites) e inflamação nas articulações (artrite) também podem ser observados.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 11 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 18 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Nenhum gene associado encontrado
Os dados genéticos desta condição ainda estão sendo catalogados.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
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Publicações mais relevantes
Eosinophilic Fasciitis in Pediatric Patients: A Rare but Distinct Autoimmune Fibrosing Disorder.
Eosinophilic fasciitis (EF), or Shulman syndrome, first described in 1974, is a rare fibrosing disorder characterized by painful, symmetric swelling and progressive woody induration of skin and subcutaneous tissues. Although the pathogenesis remains unclear, EF is considered immune-mediated, often triggered by physical exertion, infections, or medications. Pediatric EF, a particularly uncommon subset, can exhibit distinct clinical features, including pronounced extracutaneous manifestations, unpredictable disease progression, and variable therapeutic responses. Clinical presentations range from rapidly advancing fibrosis leading to joint contractures to fluctuating inflammatory episodes. Diagnosis is challenging because of the absence of universal criteria, although peripheral eosinophilia, elevated inflammatory markers, and imaging findings support clinical suspicion. Definitive diagnosis depends on deep skin and fascial biopsy, revealing eosinophil-rich lymphoplasmacytic infiltrates and fibrosis. Management primarily relies on systemic corticosteroids, supplemented by steroid-sparing immunosuppressive medications in refractory cases. Early diagnosis and treatment are critical because untreated EF can cause irreversible fibrosis and significant functional impairment. The disease's rarity, heterogeneous presentations, and unclear etiology further complicate clinical management. Recent insights suggest EF may involve intricate interactions among environmental triggers, immune dysregulation, and fibrotic remodeling. This review aims to provide an updated overview of pediatric EF, highlighting current knowledge on clinical manifestations, diagnosis, differential diagnosis, therapeutic approaches, and outcomes, supported by an illustrative case, with emphasis on areas needing further research.
Eosinophilic Fasciitis.
This Patient Page describes the symptoms, diagnosis, and treatment of eosinophilic fasciitis.
Two case reports of eosinophilic fasciitis with onset after immune checkpoint inhibitor cessation.
Immune checkpoint inhibitors (ICIs) are known to cause a wide spectrum of immune-related adverse events (irAEs). Among these, eosinophilic fasciitis (EF) is a rare, fibrosing disorder causing inflammatory infiltration of subcutaneous fat and fascia. It is characterized clinically by edema and subsequent induration and tightening of the skin and subcutaneous tissues. Several case reports have documented EF secondary to ICIs in patients on active treatment. Herein, we present two cases of delayed EF following treatment cessation with avelumab for metastatic urothelial carcinoma (Case 1) and following adjuvant nivolumab completion for stage IIIC melanoma (Case 2). Both patients had typical exam findings including erythema/edema of the extremities and trunk and diffuse thickening of subcutaneous fat and fascia, leading to severe respiratory restriction in Case 1. Both patients were diagnosed with EF by full-thickness skin biopsy showing sclerosis and lymphocytic infiltration of the subcutaneous fat and/or fascia. Only one of the two patients presented with definite eosinophilia. Both cases were treated with glucocorticoids and had early recurrence of symptoms post steroid taper, necessitating subsequent protracted steroid and steroid sparing agent use. Overall, we demonstrate the importance of considering delayed irAEs, specifically autoimmune fibrotic skin diseases even when ICI therapy has been discontinued. We underscore the need for collaboration between oncology and rheumatology as the scope of ICI treatments for cancer continues to expand.
[Shulman syndrome: An atypical presentation of a rare disease].
Eosinophilic fasciitis is a rare scleroderma-like disorder. Most of the available information comes from case reports or small case series. It is characterized by fascial thickening, acute pain, skin induration, joint contractures, and, anecdotally, visceral involvement. Diagnosis is confirmed through deep biopsy, although magnetic resonance imaging may be useful in inconclusive cases. We describe the case of a previously healthy 32-year-old man male with a history of recurrent minor trauma to the lumbar and gluteal regions. He developed acute-onset pain and progressive deep induration in the affected regions, which later extended symmetrically to all four extremities. Initial magnetic resonance imaging suggested lymphedema; however, given the high clinical suspicion, images were re-evaluated, revealing findings consistent with fasciitis. Treatment with corticosteroids and methotrexate was initiated, resulting in rapid improvement of residual pain and gradual reduction of deep induration. This case highlights the heterogeneous presentation of eosinophilic fasciitis and underscores the importance of including it in the differential diagnosis of scleroderma-like disorders, as well as the role of magnetic resonance imaging in ambiguous cases. la fascitis eosinofílica es un trastorno esclerodermiforme poco frecuente. La mayor parte de la información disponible proviene de reportes y series de casos. Se caracteriza por engrosamiento de la fascia, dolor agudo, endurecimiento cutáneo, contracturas articulares y, de manera anecdótica, compromiso orgánico. El diagnóstico se confirma mediante biopsia profunda; sin embargo, la resonancia magnética puede ser de utilidad en casos no concluyentes. se describe el caso de un hombre de 32 años, previamente sano, con antecedente de trauma leve repetido en la región lumbar y glútea. El paciente desarrolló dolor súbito e induración profunda progresiva en las regiones comprometidas, con extensión posterior y simétrica a las cuatro extremidades. La resonancia magnética inicial sugirió linfedema; no obstante, ante la alta sospecha clínica, se realizó una reinterpretación del estudio, evidenciándose hallazgos sugestivos de fascitis. Se inició tratamiento con esteroides y metotrexato, con rápida mejoría del dolor residual y disminución paulatina de la induración profunda. este caso destaca la presentación heterogénea de la fascitis eosinofílica y la importancia de considerarla dentro del diagnóstico diferencial de los trastornos esclerodermiformes, así como el papel relevante de la resonancia magnética en escenarios diagnósticos ambiguos.
Rituximab and Intravenous Immunoglobulin (IVIG) for Refractory Eosinophilic Fasciitis: A Case Report.
Eosinophilic fasciitis (EF) is a rare condition with an unknown cause. This case study showed that a 40-year-old man with EF did not respond to standard treatments but improved after receiving rituximab and intravenous immunoglobulin (IVIG). Further studies are needed to confirm rituximab's effectiveness and long-term safety for EF.
Publicações recentes
Novel Combination of UVA-1 Phototherapy With Topical Tofacitinib for Treating Eosinophilic Fasciitis With Morphea: Case Report.
Eosinophilic fasciitis (EF): an unusual case presentation with literature review.
Ischemic stroke despite therapeutic anticoagulation in eosinophilic fasciitis with compartment syndrome and deep vein thrombosis: a case report.
Two case reports of eosinophilic fasciitis with onset after immune checkpoint inhibitor cessation.
[Shulman syndrome: An atypical presentation of a rare disease].
📚 EuropePMC728 artigos no totalmostrando 189
Ischemic stroke despite therapeutic anticoagulation in eosinophilic fasciitis with compartment syndrome and deep vein thrombosis: a case report.
Thrombosis journalTwo case reports of eosinophilic fasciitis with onset after immune checkpoint inhibitor cessation.
Frontiers in oncology[Shulman syndrome: An atypical presentation of a rare disease].
Revista medica del Instituto Mexicano del Seguro SocialEosinophilic Fasciitis in Pediatric Patients: A Rare but Distinct Autoimmune Fibrosing Disorder.
Pediatrics in reviewRituximab and Intravenous Immunoglobulin (IVIG) for Refractory Eosinophilic Fasciitis: A Case Report.
Clinical case reportsIdiopathic inflammatory myopathies: a comprehensive review, new concepts on diagnostic imaging and whole-body MRI.
European radiology[Eosinophilic fascitis: A case report and literature review].
Revista medica del Instituto Mexicano del Seguro Social[A typical myofascial pain syndrome, or perhaps not? : Rare differential diagnosis].
Innere Medizin (Heidelberg, Germany)[POEMS syndrome misdiagnosed as systemic sclerosis: A case report].
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciencesEosinophilic Fasciitis in a Young Adult: A Rare Presentation Potentially Triggered by the Epstein-Barr Virus.
CureusThe utility of rituximab in patients with eosinophilic fasciitis: case series from an Australian tertiary multidisciplinary clinic.
Clinical rheumatologyEnterohepatic Non-H. pylori Helicobacter Infection in a Patient With X-Linked Agammaglobulinemia.
Pediatric dermatologyEosinophilic fasciitis: A case report and literature review.
MedicineA phase 2b basket trial approach to treat multiple rare and fibrotic skin diseases.
Frontiers in medicineEosinophilic Fasciitis in a 78-Year-Old Man Following Pembrolizumab Treatment for Bladder Cancer.
The American journal of case reportsNivolumab-Induced Fasciitis Mimicking Scleroderma: A Diagnostic Challenge.
CureusEosinophilic fasciitis associated with Sjögren's disease: a rare case.
Scandinavian journal of rheumatologyCancer Risk in Autoimmune and Immune-Mediated Diseases: A Narrative Review for Practising Clinicians.
Journal of clinical medicineClinicopathological Challenge: A Progressively Enlarging Hardened Skin Plaque.
International journal of dermatologyEosinophilic Fasciitis after Covid Infection: A Case Report and Review of Literature.
Clinical medicine & researchCoexistence of eosinophilic fasciitis and systemic lupus erythematosus: a case-based review.
Modern rheumatology case reportsEosinophilic Fasciitis with Isolated Hand Involvement: A Diagnostic Challenge.
Archives of rheumatologyDiagnosis and treatment of early eosinophilic fasciitis: a case report.
Journal of medical case reportsLocalized scleroderma: multiparametric MRI with diffusion-weighted imaging and gadolinium-based perfusion imaging for assessing disease activity.
Skeletal radiologyEosinophilic Fasciitis: New Developments and Future Directions.
International journal of dermatologyEosinophilic Fasciitis and Morphea Share Gene Signatures of Inflammatory Cell Death, Self-DNA Recognition, and Enhanced Jak/Signal Transducer and Activator of Transcription Signaling.
The Journal of investigative dermatologyRecurrent Eosinophilic Fasciitis: The First Case Report.
Clinical, cosmetic and investigational dermatologyImmune checkpoint inhibitor-related eosinophilic fasciitis: 3 case reports with literature review.
La Revue de medecine interneClinicopathological profile of eosinophilic fasciitis: a retrospective cohort study from a neuromuscular disorder center in China.
Arthritis research & therapyTreatment Outcomes of Eosinophilic Fasciitis: A Systematic Review.
Journal of cutaneous medicine and surgeryEosinophilic fasciitis following postpartum: A rare case report.
The Journal of international medical researchA case report on the implantation of a leadless pacemaker in a patient with eosinophilic fasciitis and third-degree atrioventricular block.
BMC cardiovascular disorders[Analysis of ultrasound as an adjunctive diagnostic tool for eosinophilic fasciitis].
Zhonghua nei ke za zhiNavigating complexity through "the groove": eosinophilic fasciitis in the context of diabetes and lichen planus.
Journal of rheumatic diseasesLocalized scleroderma: anatomic MRI findings of morphea with inter-reader analysis.
Skeletal radiologyUnilateral Eosinophilic Fasciitis With Hand Involvement: A Case Report.
Clinical case reportsTreatment and Monitoring of Eosinophilic Fasciitis.
Current treatment options in rheumatologyEosinophilic fasciitis induced by immune checkpoint inhibitors successfully controlled with dapsone.
European journal of dermatology : EJDOverlap of generalized morphea and eosinophilic fasciitis after recreational exposure to epoxy resin.
JAAD case reportsCharacteristics and factors associated with treatment response among patients with eosinophilic fasciitis: a systematic review and meta-analysis.
Rheumatology internationalEosinophil-induced adverse events induced by treatment with programmed cell death 1/ligand 1 inhibitors: A comprehensive disproportionality analysis of the FDA adverse event reporting system.
International journal of cancer[Target organ connective tissue: the variability of systemic fibrosis].
Innere Medizin (Heidelberg, Germany)[Mysterious connective tissue disease: Eosinophilic Fasciitis].
MMW Fortschritte der MedizinCase Series: Extracutaneous Findings of Eosinophilic Fasciitis Patients.
International journal of rheumatic diseasesEosinophilic Fasciitis: A Case Series.
CureusRestricted Movement Associated with Unilateral Diffuse Fasciitis.
Internal medicine (Tokyo, Japan)A Challenging Case of Eosinophilic Fasciitis Without Classic Histopathological Findings.
The Permanente journalUnraveling Shulman's syndrome: A rare case of eosinophilic fasciitis in a pediatric patient with fascial abnormalities on MRI.
Radiology case reportsPediatric eosinophilic fasciitis: similarities and differences with adult forms.
European journal of pediatricsClinical Images: Groove sign: heeding clue to eosinophilic fasciitis.
ACR open rheumatologyEosinophilic fasciitis, a rare cause of skin thickening: a case report.
ARP rheumatology18F-FDG PET/CT: The turning point in eosinophilic fasciitis diagnosis in a pediatric patient.
European journal of nuclear medicine and molecular imagingEosinophilic fasciitis and breast cancer: a case report highlighting recurrence signals.
Dermatology reportsClinical signs and utility of CT PET scan in eosinophilic fasciitis?
Skin health and disease[Atypical and/or systemic dermatologic disorders related to immune checkpoint inhibitors: A review].
La Revue de medecine interneDiagnostic and prognostic performance of positron emission tomography/computed tomography in eosinophilic fasciitis: An observational multicenter retrospective study.
Journal of the American Academy of DermatologyA global retrospective study identifies higher rates of pernio in individuals with connective tissue disease.
Journal of the American Academy of DermatologyEosinophilic Fasciitis Following Infection With COVID-19.
Irish medical journalEosinophilic fasciitis with extensive cutaneous presentation.
Rheumatology (Oxford, England)A Case Report of Atypical Migratory Shulman Syndrome.
CureusA Case of Eosinophilic Fasciitis.
Current rheumatology reviewsUltrasound-guided core needle biopsy of deep fascia: A cadaveric study evaluating feasibility, accuracy and reliability.
Clinical anatomy (New York, N.Y.)[Translated article] Refractory Eosinophilic Fasciitis: Good Response to Ocrelizumab in a Patient with Multiple Sclerosis Under Treatment with Natalizumab.
Actas dermo-sifiliograficasEosinophilic Fasciitis: A Classic Presentation.
Mayo Clinic proceedingsEosinophilia-myalgia syndrome presenting with overlapping features of eosinophilic fasciitis and sarcoidal granulomas.
JAAD case reportsUnmasking the Veiled Intruder: A Complicated Case of Eosinophilic Fasciitis.
CureusEosinophilic fasciitis: unraveling the clinical tapestry of a rare case and review of literature.
Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieAutologous haematopoiesis stem cell transplantation (AHSCT) for treatment-refractory autoimmune diseases in children.
RMD openUnilateral eosinophilic fasciitis (Shulman syndrome) with excellent response to combined treatment with methotrexate therapy and compression brace.
Dermatology reportsJoint Sparing: The Key to Unlocking Early Treatment Success in Eosinophilic Fasciitis.
CureusPower Doppler ultrasonography findings of eosinophilic fasciitis.
Rheumatology advances in practiceThe use of dupilumab in treatment-refractory eosinophilic fasciitis.
Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & ImmunologyA Severe Case of Overlap of Morphea and Eosinophilic Fasciitis after Burn Injuries.
Case reports in rheumatologyOphthalmic vascular manifestations in eosinophil-associated diseases: a comprehensive analysis of 57 patients from the CEREO and EESG networks and a literature review.
Frontiers in immunologyA difficult diagnosis of eosinophilic fasciitis: A case report.
SAGE open medical case reportsA case of overlap between eosinophilic fasciitis and generalized morphea.
Dermatology reportsFunctional and Cutaneous Treatment Outcomes With Intravenous Immunoglobulin for Eosinophilic Fasciitis: A Retrospective Study.
Journal of drugs in dermatology : JDD[Eosinophilic fasciitis: From pathophysiology to therapeutics].
La Revue de medecine interneCharacteristics and management of sclerosing skin diseases during immune checkpoint inhibitor therapy: An evidence-based review.
Journal of the American Academy of DermatologyEosinophilic Fasciitis in a 68-Year-Old Female.
CureusJuvenile eosinophilic fasciitis: a single center case series.
Pediatric rheumatology online journalEosinophilic Fasciitis Illustrated by 18 F-FDG PET/CT.
Clinical nuclear medicineEosinophilic fasciitis following COVID-19: A case series of 3 patients.
JAAD case reportsIs there a Role for Anti-IL-5 Therapies in Eosinophilic Fasciitis?
Mediterranean journal of rheumatologyEosinophilic Fasciitis Presenting as Chronic Nonspecific Symptoms in a Young Adult.
Oxford medical case reportsRole of ultrasound in guiding the biopsy site in eosinophilic fasciitis.
Rheumatology and immunology researchThe realistic positioning of UVA1 phototherapy after 25 years of clinical experience and the availability of new biologics and small molecules: a retrospective clinical study.
Frontiers in medicineGroove sign in eosinophilic fasciitis.
QJM : monthly journal of the Association of PhysiciansThe first case of SARS-CoV-2-induced eosinophilic fasciitis.
Modern rheumatology case reportsThe clinical challenge of refractory eosinophilic fasciitis.
Porto biomedical journalNivolumab-induced eosinophilic fasciitis: An unusual immune-related adverse event that needs to be recognized by practitioners.
Annales de dermatologie et de venereologieEosinophilic Fasciitis Possibly Provoked by Exercise.
SkinmedMorphea, Eosinophilic Fasciitis and Cancer: A Scoping Review.
CancersHigh-resolution musculoskeletal ultrasonography and elastography for eosinophilic fasciitis diagnosis and follow-up: a case-based review.
Rheumatology internationalEosinophilic fasciitis in a young male auto mechanic exposed to organic solvents.
ReumatismoA case of paradoxical eosinophilic fasciitis in a patient on benralizumab.
JAAD case reportsUtility of magnetic resonance imaging in the diagnosis of eosinophilic fasciitis: A multicenter retrospective cohort study.
Journal of the American Academy of DermatologyEosinophilic fasciitis in eosinophilic granulomatosis with polyangiitis.
Rheumatology (Oxford, England)Immunologic and nonimmunologic sclerodermal skin conditions - review.
Frontiers in immunologyDiagnostic imaging for eosinophilic fasciitis: A systematic review.
JAAD internationalEosinophilic Fasciitis: A Rare Mimicker of Systemic Sclerosis.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseasesDiffuse fasciitis with eosinophilia in boys: a case-based review.
Rheumatology internationalCheckpoint Inhibitor-Associated Scleroderma and Scleroderma Mimics.
Pharmaceuticals (Basel, Switzerland)Mepolizumab for refractory eosinophilic fasciitis: a retrospective analysis from two tertiary care centres.
Clinical and experimental rheumatologyTocilizumab in the Treatment of Eosinophilic Fasciitis: A Case Study and Review of Literature.
Mediterranean journal of rheumatologyEosinophilic fasciitis difficult to differentiate from scleroderma: A case report.
World journal of clinical casesDiagnostic Utility of Magnetic Resonance Imaging in Eosinophilic Fasciitis: A Case Report and Review of Literature.
CureusEosinophil-related diseases during treatment with glucagon-like peptide one receptor (GLP-1 RA): a case report and review of the literature.
Clinical rheumatologyEosinophilic fasciitis following SARS-CoV-2 vaccination.
JAAD case reportsClinical characteristics and risk factors of patients with eosinophilic fasciitis associated with pleural effusion.
Scientific reportsEosinophilic fasciitis may present as a paraneoplastic syndrome of hematological malignancies-A systematic review.
JAAD internationalEosinophilic Fasciitis Presenting as an Ichthyosiform Eruption of the Bilateral Ankles.
Case reports in dermatology[Clinical characteristics, ultrasonic diagnosis, treatment and outcomes of eosinophilic fasciitis: a retrospective single-center analysis of 45 cases].
Nan fang yi ke da xue xue bao = Journal of Southern Medical UniversityAdditional Diagnoses to Consider in Eosinophilic Fasciitis.
The American journal of medicineClinical and histopathological features of hypereosinophilic syndrome with cutaneous involvement: The Mayo Clinic Experience.
Journal of cutaneous pathologyEosinophilic Fasciitis: Current and Remaining Challenges.
International journal of molecular sciences[Immune checkpoint inhibitor-induced eosinophilic fasciitis: a case report and literature review].
Zhonghua nei ke za zhi[Paraneoplastic syndromes in rheumatology].
Zeitschrift fur RheumatologieAutoimmune comorbidities and antibody markers associated with eosinophilic fasciitis.
JAAD internationalThe impact of skin disfigurement in patients with autoimmune connective tissue disorders on quality of life, willingness-to-pay, and time trade-off: A cross-sectional analysis.
JAAD internationalSuccessful treatment of eosinophilic fasciitis with the anti-IL5 receptor monoclonal antibody benralizumab.
Clinical and experimental rheumatologyCase report: Eosinophilic fasciitis induced by pembrolizumab with high FDG uptake on 18F-FDG-PET/CT.
Frontiers in medicineAn Unusual Presentation of a Rare Disease: Eosinophilic Fasciitis.
CureusEosinophilic Fasciitis Without Skin Sclerosis.
The Journal of rheumatologyLichen planus associated with eosinophilic fasciitis outside the setting of chronic graft-versus-host disease.
Annales de dermatologie et de venereologie[Eosinophilic dermatoses].
Dermatologie (Heidelberg, Germany)Diagnosis and Management of Cutaneous Manifestations of Autoimmune Connective Tissue Diseases.
Clinical, cosmetic and investigational dermatologyGleich syndrome and eosinophilic fasciitis overlap successfully treated with mepolizumab.
The Journal of dermatologyAn unusual case of eosinophilia, myalgia and skin contractures: Shulman's disease revisited.
Medical journal, Armed Forces IndiaEosinophilic fasciitis (Shulman syndrome)-recognition of the histological spectrum allows for new insights into possible pathomechanisms.
Rheumatology (Oxford, England)Dystrophic calcinosis in eosinophilic fasciitis.
Clinical rheumatologyGraft versus host disease-related eosinophilic fasciitis: cohort description and literature review.
Advances in rheumatology (London, England)Cluster analysis reveals eosinophilia and fibrosis as poor prognostic markers in 128 patients with eosinophilic fasciitis.
Journal of the American Academy of DermatologyDupilumab for treatment of eosinophilic fasciitis.
Clinical and experimental dermatologyThe groove sign in eosinophilic fasciitis.
Clinical rheumatologyHidden in Plain Sight: Eosinophilic Fasciitis.
The American journal of medicineEosinophilic Fasciitis: A Rare and Challenging Diagnosis in a Free Clinic Setting.
CureusEosinophilic fasciitis induced by certolizumab pegol: association or coincidence?
Clinical and experimental rheumatologyApplication of ultrasound in a case of eosinophilic fasciitis mimicking stiff-person syndrome.
Neuromuscular disorders : NMDEosinophilic Fasciitis with Concurrent Necrobiotic Granulomatous Dermatitis Related to Checkpoint Inhibition Therapy.
Journal of immunotherapy and precision oncologyMRI Findings of Eosinophilic Fasciitis.
Journal of the Belgian Society of Radiology[Imaging of eosinophilic fasciitis in ultrasound and MRI (magnetic resonance imaging): a case report].
Zeitschrift fur RheumatologieClinical guide to eosinophilic fasciitis: straddling dermatology and rheumatology.
Expert review of clinical immunologyEfficacy of methotrexate for steroid-resistant eosinophilic fasciitis with delayed start of treatment: a case report.
International journal of dermatologyEosinophilic Fasciitis and Smoldering Multiple Myeloma: An Exceptional Association in Young Adults.
CureusEosinophilic Fasciitis with Hypereosinophilia as the Initial Clinical Manifestation of Peripheral T-Cell Lymphoma, Not Otherwise Specified.
Internal medicine (Tokyo, Japan)Methotrexate injection site reactions: Case report and literature review.
JAAD case reportsRecalcitrant digital calcinosis cutis successfully treated with intralesional sodium thiosulfate under digital nerve blockade.
BMJ case reportsRefractory eosinophilic fasciitis successfully treated with infliximab: A case report.
Journal of scleroderma and related disordersTocilizumab in the treatment of eosinophilic fasciitis: Case report and literature review.
Revista clinica espanolaSclerotic skin disease development following COVID-19 vaccination.
JAAD case reportsEosinophilic Fasciitis following Checkpoint Inhibitor Therapy with Pembrolizumab.
Mediterranean journal of rheumatologyEosinophilic fasciitis: experience with a patient and review of the potential mimics.
Acute medicineEosinophilic fasciitis induced by a game of drumming probably via type 2 innate immunity.
International journal of rheumatic diseasesCutaneous Immune-Related Adverse Events Secondary to Immune Checkpoint Inhibitors and Their Management.
Critical reviews in immunologyEosinophilic fasciitis (Shulman disease) with clinical, imaging and pathological correlation.
BMJ case reportsBaricitinib for Refractory Eosinophilic Fasciitis: Myth or Reality?
The Journal of rheumatologyNivolumab-induced multiple morphea associated with eosinophilic fasciitis.
European journal of dermatology : EJDUVA-1 phototherapy as adjuvant treatment for eosinophilic fasciitis: in vitro and in vivo functional characterization.
International journal of dermatologyControversy around the morphea.
Postepy dermatologii i alergologiiDiagnosis and treatment of eosinophilic fasciitis: Report of two cases.
World journal of clinical casesEarly-life inflammation primes a T helper 2 cell-fibroblast niche in skin.
NatureCharacteristics and Outcomes of Eosinophilic Fasciitis-Associated Monoclonal Gammopathy.
JAMA dermatologyEosinophilic fasciitis as a paraneoplastic syndrome in melanoma.
JAAD case reportsEosinophilic Fasciitis Unmasking a Lung Cancer.
The American journal of medicineEosinophilic Fasciitis With a Malignant Outcome.
Journal of medical casesSystemic mesalazine treatment prevents spontaneous skin fibrosis in PLK2-deficient mice.
Naunyn-Schmiedeberg's archives of pharmacologyDrug-Associated Eosinophilic Fasciitis: A Case of Eosinophilic Fasciitis Secondary to Cemiplimab Therapy.
The American journal of case reportssQuiz your knowledge! Eosinophilic fasciitis.
European journal of dermatology : EJDSuccessful Treatment With Baricitinib in a Patient With Refractory Eosinophilic Fasciitis.
The Journal of rheumatologyComplete reversibility of pembrolizumab-induced eosinophilic fasciitis without corticosteroids: A case report.
SAGE open medical case reportsAntibody responses after documented COVID-19 disease in patients with autoimmune rheumatic disease.
Clinical rheumatologyDrug-induced eosinophilic fasciitis: A dual pharmacovigilance analysis.
Journal of the American Academy of DermatologyRituximab for refractory eosinophilic fasciitis: a case series with long-term follow-up and literature review.
Rheumatology internationalMusculoskeletal ultrasound as a diagnostic tool for eosinophilic fasciitis and correlation with magnetic resonance imaging findings.
International journal of rheumatic diseasesBiologic treatment outcomes in refractory eosinophilic fasciitis: A systematic review of published reports.
Journal of the American Academy of DermatologyClinical experience with biologic treatment in resistant eosinophilic fasciitis: Case reports and review of the literature.
MedicineThe enigmatic fascia: eosinophilic fasciitis.
Journal of osteopathic medicineNot just eosinophilic fasciitis.
Journal of medicine and lifeEosinophilic fasciitis (Shulman syndrome), a rare entity and diagnostic challenge, as a manifestation of severe chronic graft-versus-host disease: a case report.
Journal of medical case reportsThe place of 18F FDG PET/CT in the management of patients with eosinophilic fasciitis: a case report.
ReumatismoMycophenolate mofetil and mycophenolic acid for the treatment of eosinophilic fasciitis: report of two cases and literature review.
The Journal of dermatological treatmentEosinophilic fasciitis induced by natalizumab in a patient affected by multiple sclerosis.
Indian journal of dermatology, venereology and leprologyEosinophilic fasciitis in a pregnant woman with corticosteroid dependence and good response to infliximab.
Rheumatology international18F-FDG PET/CT and MRI findings of Shulman syndrome also known as eosinophilic fasciitis.
European journal of nuclear medicine and molecular imagingEosinophilic Fasciitis - Clinical Features and Therapeutic Management.
Acta dermatovenerologica Croatica : ADCSkin puckering and edema during durvalumab therapy.
JAAD case reportsA "groovy" diagnosis: Eosinophilic fasciitis.
Clinical case reportsNivolumab-induced plaque morphea in a malign melanoma patient.
Journal of cosmetic dermatologyAssociações
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Doenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Perguntas frequentes
O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu
A causa exata subjacente da afecção ainda é classificada como desconhecida pelos catálogos de genética médica. Até o momento, não foram catalogados genes causadores específicos nem variantes patogênicas no banco de dados ClinVar.
Referências
Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete
8 publicações do grafo RarasNet (PubMed) · 7 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Citar este verbete
Raras. (s.d.). Fasceíte eosinofílica. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/fasceite-eosinofilica
Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
Fasceíte eosinofílica
📋 Origem dos dados
Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.
- Doença rara (ontologia)
- fonte: Orphanet
- Identificador unificado
- fonte: MONDO
- Genética mendeliana
- fonte: OMIM
- Codificação WHO/SUS
- fonte: WHO ICD-10 / DATASUS
- CID-11 (futuro)
- fonte: WHO ICD-11
- NIH/GARD
- fonte: GARD (NIH)
- Indexação biomédica
- fonte: MeSH (NLM)
- Dado público estruturado
- fonte: Wikidata
- Ensaios clínicos
- fonte: ClinicalTrials.gov
