Pular para o conteúdo
Fenda palatina
ORPHA:2014CID-10 · Q35CID-11 · LA42DOENÇA RARA
Esta doença tem causa genética. Recomendamos procurar um médico geneticista para diagnóstico, exames genéticos e aconselhamento familiar.
AudiçãoInício neonatalHerança Complex/Unknown

A fenda palatina é uma embriopatia do tipo fissura que afeta o palato mole e duro em graus variados.

Última verificação: Fonte: sem afirmação sobre o SUS a verificarEm construçãohistóricoSugerir correção
Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

💬
EM LINGUAGEM SIMPLES

A fenda palatina é uma abertura congênita no céu da boca que atinge o palato mole e o palato duro. Os bebês e as crianças com a condição podem ter dificuldade para mamar, refluxo de leite pelo nariz, infecções de ouvido recorrentes e alterações no som da fala. Embora a doença não tenha um PCDT específico nem remédios próprios dispensados na lista de doenças raras do SUS, a rede pública oferece procedimentos diagnósticos genéticos e atendimento em reabilitação. O cuidado envolve reabilitação contínua e procedimentos especializados, existindo diversas pesquisas clínicas em andamento no mundo e no Brasil.

📋
Informacoes curadas por IA — podem conter imprecisoes

A fenda palatina é uma embriopatia do tipo fissura que afeta o palato mole e duro em graus variados.

Pesquisas ativas
29 ensaios
127 total registrados no ClinicalTrials.gov
Publicações científicas
16.380 artigos
Último publicado: 2026 Apr 15

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-5 / 10 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
0.0
Europe
Início
Antenatal
+ neonatal
🏥
SUS: Cobertura mínimaScore: 15%
5 procedimentos SIGTAPCID-10: Q35
🇧🇷Dados SUS / DATASUS
EXAMES E PROCEDIMENTOS RELACIONADOS (5)
•
Cariótipo — bandas G, Q ou R
•
Pesquisa de microdeleções/microduplicações por FISH
•
Sequenciamento completo do exoma (WES)
•
Dosagem de alfa-fetoproteína
•
Atendimento em reabilitação — doenças raras
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

😀
Face
17 sintomas
🧬
Pele e cabelo
8 sintomas
🦷
Dentes
7 sintomas
🦴
Ossos e articulações
5 sintomas
👂
Ouvidos
3 sintomas
👁️
Olhos
3 sintomas

+ 19 sintomas em outras categorias

Características mais comuns

—
Estenose do canal auditivo externo
—
Má oclusão dentária
—
Dificuldades alimentares na infância
—
Apneia obstrutiva do sono
—
Comprometimento da linguagem
—
Morfologia anormal da cavidade oral
72sintomas
Sem dados (72)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 72 características clínicas mais associadas, ordenadas por frequência.

Estenose do canal auditivo externoStenosis of the external auditory canal
Má oclusão dentáriaDental malocclusion
Dificuldades alimentares na infânciaFeeding difficulties in infancy
Apneia obstrutiva do sonoObstructive sleep apnea
Comprometimento da linguagemLanguage impairment

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico16.380PubMed
Últimos 10 anos200publicações
Pico2026160 papers
Linha do tempo
2026Hoje · 2026🧪 1995Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

Genes associados

4 genes identificados com associação a esta condição. Padrão de herança: Multigenic/multifactorial, Not applicable.

TBX22T-box transcription factor TBX22Disease-causing germline mutation(s) inAltamente restrito
MECANISMO DE DOENÇA

Cleft palate with or without ankyloglossia, X-linked

A congenital mouth abnormality characterized by fissure of the soft and/or hard palate, due to faulty fusion. Some patients also manifest ankyloglossia, a condition in which movements of the tongue are restricted. Complete ankyloglossia is due to fusion between the tongue and the floor of the mouth. Partial ankyloglossia is due to a short lingual frenum or one which is attached too near the tip of the tongue.

EXPRESSÃO TECIDUAL(Tecido-específico)
Testículo
38.6 TPM
Tireoide
14.2 TPM
Aorta
0.2 TPM
Coração - Átrio
0.1 TPM
Nervo tibial
0.1 TPM
INTERAÇÕES PROTEICAS (4)
OUTRAS DOENÇAS (2)
Abruzzo-Erickson syndromecleft palate with or without ankyloglossia, X-linked
HGNC:11600UniProt:Q9Y458
GRHL3Grainyhead-like protein 3 homologCandidate gene tested inAltamente restrito
MECANISMO DE DOENÇA

Van der Woude syndrome 2

An autosomal dominant developmental disorder characterized by lower lip pits, cleft lip and/or cleft palate.

EXPRESSÃO TECIDUAL(Tecido-específico)
Esôfago - Mucosa
141.8 TPM
Vagina
78.8 TPM
Skin Not Sun Exposed Suprapubic
64.5 TPM
Skin Sun Exposed Lower leg
64.2 TPM
Testículo
3.9 TPM
INTERAÇÕES PROTEICAS (3)
OUTRAS DOENÇAS (6)
van der Woude syndrome 2submucosal cleft palatecleft soft palatebifid uvula
HGNC:25839UniProt:Q8TE85
UBBPolyubiquitin-BCandidate gene tested inTolerante
VIAS BIOLÓGICAS (1)
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
EXPRESSÃO TECIDUAL(Ubíquo)
Testículo
592.0 TPM
Linfócitos
427.6 TPM
Sangue
426.1 TPM
Brain Spinal cord cervical c-1
409.3 TPM
Pituitária
406.5 TPM
OUTRAS DOENÇAS (4)
submucosal cleft palatecleft soft palatebifid uvulacleft hard palate
HGNC:12463UniProt:P0CG47
TP63Tumor protein 63Disease-causing germline mutation(s) inAltamente restrito
VIAS BIOLÓGICAS (9)
TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseRegulation of TP53 Activity through Association with Co-factorsActivation of PUMA and translocation to mitochondriaTP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainTP53 Regulates Transcription of Death Receptors and Ligands
MECANISMO DE DOENÇA

Acro-dermato-ungual-lacrimal-tooth syndrome

A form of ectodermal dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial clefting. Inheritance is autosomal dominant.

EXPRESSÃO TECIDUAL(Tecido-específico)
Skin Not Sun Exposed Suprapubic
138.8 TPM
Skin Sun Exposed Lower leg
115.7 TPM
Vagina
77.8 TPM
Esôfago - Mucosa
71.8 TPM
Próstata
17.5 TPM
OUTRAS DOENÇAS (15)
orofacial cleft 8limb-mammary syndromepremature ovarian failure 21ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
HGNC:15979UniProt:Q9H3D4

Variantes genéticas (ClinVar)

233 variantes patogênicas registradas no ClinVar.

🧬 TBX22: GRCh37/hg19 Xq13.1-22.2(chrX:70460290-103312921)x3 ()
🧬 TBX22: GRCh37/hg19 Xq21.1-22.3(chrX:77574432-106660031)x1 ()
🧬 TBX22: NM_001109878.2(TBX22):c.331G>A (p.Glu111Lys) ()
🧬 TBX22: NM_001109878.2(TBX22):c.864-31G>A ()
🧬 TBX22: GRCh37/hg19 Xq13.1-22.3(chrX:69013433-104620838)x2 ()
Ver todas no ClinVar

Classificação de variantes (ClinVar)

Distribuição de 226 variantes classificadas pelo ClinVar.

23
180
23
Patogênica (10.2%)
VUS (79.6%)
Benigna (10.2%)
VARIANTES MAIS SIGNIFICATIVAS
ABL1: NM_005157.6(ABL1):c.2204C>T (p.Thr735Met) [Conflicting classifications of pathogenicity]
PPP3CA: NM_000944.5(PPP3CA):c.956-17C>A [Conflicting classifications of pathogenicity]
SPECC1L: NM_015330.6(SPECC1L):c.1628A>G (p.His543Arg) [Uncertain significance]
LOC129931382: NM_005850.5(SF3B4):c.33G>A (p.Gln11=) [Uncertain significance]
ROR2: NM_004560.4(ROR2):c.1457A>C (p.Lys486Thr) [Uncertain significance]

Vias biológicas (Reactome)

44 vias biológicas associadas aos genes desta condição.

Negative Regulation of CDH1 Gene Transcription Positive Regulation of CDH1 Gene Transcription Translesion synthesis by REV1 Recognition of DNA damage by PCNA-containing replication complex Translesion Synthesis by POLH Activation of NF-kappaB in B cells ISG15 antiviral mechanism Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants ER-Phagosome pathway Downregulation of ERBB4 signaling Spry regulation of FGF signaling Downregulation of ERBB2:ERBB3 signaling Budding and maturation of HIV virion NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment DDX58/IFIH1-mediated induction of interferon-alpha/beta APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Membrane binding and targetting of GAG proteins Assembly Of The HIV Virion APC-Cdc20 mediated degradation of Nek2A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G EGFR downregulation SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex TCF dependent signaling in response to WNT Activation of PUMA and translocation to mitochondria Pyroptosis TP53 Regulates Metabolic Genes TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Caspase Activators and Caspases TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin Developmental Lineage of Mammary Gland Luminal Epithelial Cells Developmental Lineage of Mammary Gland Myoepithelial Cells Developmental Lineage of Mammary Stem Cells

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
✓Aprovado5
3Fase 36
2Fase 27
1Fase 11
·Pré-clínico81
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 100 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Fenda palatina

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Onde estão os ensaios

Com ensaio aberto em 13 países. O ponto verde marca onde há vaga agora.

🟢 Recrutando agora

20 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT07752849 · Palatoplasty Techniques Using PRF and Gentamicin-Loaded PRF …Recrutando
NAYemen
NCT07048418 · Aesthetic and Functional Self-Assessment Following Rhinosept…Recrutando
🇫🇷 França
NCT06962306 · Optimizing Perioperative Analgesia to Lower Pain Following C…Recrutando
PHASE4🇺🇸 Estados Unidos
NCT06856330 · Effect of Furlow Palatoplasty With Buccal Myomucosal Flap on…Recrutando
🇪🇬 Egito
NCT05492266 · Expiratory Muscle Strength Training for Hypernasal Speech in…Recrutando
NA🇺🇸 Estados Unidos
NCT06905678 · The Financial and Emotional Impact of Cleft PalateRecrutando
🇧🇪 Bélgica
NCT07781566 · Perceptions of High and Low Intensity Speech Intervention in…Recrutando
🇧🇪 Bélgica
NCT06381713 · Effect and Cost-utility of of High Intensity vs. Low Intensi…Recrutando
NA🇧🇪 Bélgica
NCT06072495 · Etiological Study of Persistent Velopharyngeal Insufficiency…Recrutando
NA🇫🇷 França
NCT06420336 · QL vs LAI for PalatoplastyRecrutando
NA🇺🇸 Estados Unidos
NCT06505330 · Respiratory Tract Microbiome and Probiotics in Children With…Recrutando
NA🇧🇪 Bélgica
NCT05821972 · Nebulized Dexmedetomidine Combined With Ketamine Versus Nebu…Recrutando
PHASE4🇪🇬 Egito
NCT06143254 · Effect of Infant Sign Training on Speech-language Developmen…Recrutando
NA🇧🇪 Bélgica
NCT04928352 · Nebulized Bupivacaine Analgesia for Cleft Palate RepairRecrutando
PHASE3🇪🇬 Egito
NCT04342234 · Neural Network to Calculate Morphology of the Cleft Palate t…Recrutando
🇨🇭 Suíça
NCT07279883 · Length of Hospital Stay and Postoperative Analgesic Requirem…Recrutando
🇸🇪 Suécia
NCT01601171 · Genetics of Reproductive Disorders (Including Kallmann Syndr…Recrutando
🇨🇭 Suíça
NCT07692061 · Speech Intervention Frameworks in Cantonese-speaking Childre…Por convite
NAHong Kong
NCT06338319 · Book Sharing for Toddlers With CleftsPor convite
NA🇺🇸 Estados Unidos
NCT02702869 · Allied Cleft & Craniofacial Quality-Improvement and Research…Por convite
🇨🇦 Canadá · 🇺🇸 Estados Unidos

Outros ensaios clínicos

127 ensaios clínicos encontrados, 29 ativos.

Distribuição por fase
NCT07840911 · Furlow With Buccinator and Fistula FormationEm breve
NA
NCT07651904 · Perioperative Respiratory Adverse Events in Cleft Lip and Pa…Em breve
NCT07514091 · MRI Assessment of Velopharyngeal Anatomy After Modified Furl…Em breve
NA🇪🇬 Egito
NCT07434375 · Speech Intervention Via Telepractice for Children With Repai…Em breve
NA🇺🇸 Estados Unidos
NCT05357092 · Effects of AlignBabyCleft (ABaCleft)Em breve
NA
NCT07219901 · Early Intervention in Infants With Unrepaired Cleft Palate: …Em breve
NA🇺🇸 Estados Unidos
NCT06889181 · Role of Plasma Rich Growth Factor in Repair Primary Cleft Pa…Em breve
NA🇪🇬 Egito
NCT06730880 · Detection of Single Nucleotide Polymorphism (SNP) Rs2235371 …Em breve
NCT03632044 · Evaluation of Trigeminal Nerve BlockadeAtivo
PHASE4🇺🇸 Estados Unidos
NCT07734974 · Description of Pain in Pediatric Patients With Cleft Lip and…Concluído
PHASE1, PHASE2🇧🇷 Brasil
NCT00993551 · Timing of Primary Surgery for Cleft PalateConcluído
NA🇧🇷 Brasil · 🇩🇰 Dinamarca · 🇳🇴 Noruega +2
NCT00098319 · Oral Cleft Prevention Trial in BrazilConcluído
PHASE3🇧🇷 Brasil
NCT00097149 · Systematic Pediatric Care for Oral Clefts - South AmericaConcluído
NA🇧🇷 Brasil
NCT00004639 · Cleft Palate Surgery and Speech DevelopmentConcluído
PHASE2🇧🇷 Brasil · 🇺🇸 Estados Unidos
NCT07814625 · Improving the Outcomes of Nasoalveolar Molding in Complete B…Concluído
NA🇪🇬 Egito
NCT06494098 · Conventional Versus Modified Pre-surgical Naso-Alveolar Mold…Concluído
NA🇪🇬 Egito
NCT07610993 · Evaluating Salivary α - Amylase Levels Following Trigona Sp …Concluído
NAIndonesia
NCT06229587 · Furlow With Buccinator and Velopharyngeal FunctionConcluído
NA🇪🇬 Egito
NCT06807450 · Repair of Oronasal Fistula Using Interpositional Buccal Pad …Concluído
NA🇪🇬 Egito
NCT07384338 · Three Dimensional Evaluation of Dento-Skeletal Effects of Le…Concluído
NA🇪🇬 Egito
NCT06103162 · Comparison of Different Feeding Appliances for Cleft Palate …Concluído
NA🇪🇬 Egito
NCT05454670 · Effect of Collagen Matrix Graft on Palatal Fistula Formation…Concluído
NANigeria
NCT05331456 · Alveolar Cleft Repair Using Osteoinductive CeramicsConcluído
NA🇳🇱 Países Baixos
NCT05405738 · Cleft Palate Technique and Maxillary GrowthConcluído
🇪🇬 Egito
NCT07137169 · LIMA Protocol Towards Palatal Fistula and Maxillary Growth i…Concluído
NAIndonesia
NCT04928391 · A Single Bolus of Dexmedetomidine Versus Normal Saline in Po…Concluído
PHASE3🇪🇬 Egito
NCT04909619 · Suprazygomatic Maxillary Nerve Block in Cleft Palate Outcome…Concluído
NA🇺🇸 Estados Unidos
NCT04683978 · Effect of Neck Extension on Intraocular Pressure in Patients…Concluído
South Korea
NCT04616690 · Three-dimensional Cleft Lip and Palate Morphology Prior to O…Concluído
🇵🇱 Polônia
NCT04277273 · Characteristics of a Maxillofacial Prosthesis Consultation W…Concluído
NA🇫🇷 França
NCT04718558 · Optic Nerve Sheath Diameter Measurement in Cleft Palate Repa…Concluído
Turkey (Türkiye)
NCT03877666 · Assessment of the Influence of Cleft Repair on Microcirculat…Concluído
🇨🇭 Suíça
NCT05286398 · Effect of Cleft Palate Repair Using Alveolar Extension Techn…Concluído
NA🇪🇬 Egito
NCT05166408 · Fistiulation Rate Following Primary Cleft Repair≤Concluído
NA🇪🇬 Egito
NCT05196555 · Cleft Palate With Intravelar Veloplasty RepairConcluído
NA🇪🇬 Egito
NCT04489680 · Cleft Palate Surgical Simulator: Improvement in Surgical Tra…Concluído
NA🇬🇧 Reino Unido
NCT03994679 · Feasibility and Performance of Virtual Software for Virtual …Concluído
🇧🇪 Bélgica
NCT03708406 · Otologic and Rhinologic Outcomes in Children With Clef Palat…Concluído
🇫🇷 França
NCT03585608 · Optic Nerve Sheath Diameter in Patients Undergoing Palatopla…Concluído
South Korea
NCT04346173 · Palatal Lengthening Using Buccinator Myomucosal Flaps with F…Concluído
NA🇪🇬 Egito
NCT03549039 · Effect of Alveolar Bone GraftingConcluído
Turkey (Türkiye)
NCT03412474 · Suprazygomatic Block in Cleft Palate Surgery in ChildrenConcluído
PHASE2🇪🇬 Egito
NCT04725370 · Characterization of Cleft Lip and Palate Conditions in Guate…Concluído
🇺🇸 Estados Unidos
NCT06151340 · Delayed Language Development in Children With Cleft Palate a…Concluído
🇪🇬 Egito
NCT03966482 · Semi-occluded Vocal Tract Exercise in Velopharyngeal Dysfunc…Concluído
NA
NCT02923869 · Comparative Study Between Levobupivacaine and Bupivacaine fo…Concluído
PHASE2, PHASE3🇪🇬 Egito
NCT02247193 · Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Rep…Concluído
PHASE1, PHASE2🇺🇸 Estados Unidos
NCT02583100 · Improving Outcomes in Cleft Palate SurgeryConcluído
NA🇨🇦 Canadá · 🇺🇸 Estados Unidos
NCT02900014 · Validation of a Production Method of Stem Cell Isolated From…Concluído
NA🇫🇷 França
NCT03170505 · Using of Acellular Dermal Matrix in Cleft Palatal Fistula an…Concluído
NCT02415361 · Follow Ups of Parents With Infants With Cleft Lip and PalateConcluído
NA🇳🇴 Noruega
NCT04108416 · Unilateral Cleft Repair in One Surgery With Pure Primary Hea…Concluído
🇨🇭 Suíça
NCT02422056 · Acid Tranexamic Effectiveness in Reducing the Intraoperative…Concluído
PHASE4
NCT04366674 · Mordified Restoration of Tensor Veli Palatini in Cleft Palat…Concluído
NA
NCT01867632 · Acellular Dermal Matrix in Primary PalatoplastyConcluído
🇨🇦 Canadá
NCT01616953 · Cell Therapy for Craniofacial Bone DefectsConcluído
PHASE1, PHASE2🇺🇸 Estados Unidos
NCT01535131 · Furlow Palatoplasty With Tensor TenopexyConcluído
NA🇺🇸 Estados Unidos
NCT01500109 · Efficacy of Oral Versus Intravenous Acetaminophen for Primar…Concluído
NA🇺🇸 Estados Unidos
NCT02350803 · Does Use of Rigid Fixation After Removing Distraction Osteog…Concluído
PHASE2Iran
NCT02658318 · Postoperative Complications After Cleft Palate Closure in Pa…Concluído
🇧🇪 Bélgica
NCT01252264 · FaceBase BiorepositoryConcluído
🇺🇸 Estados Unidos
NCT00993993 · Relational Development in Children With Cleft Lips and Palat…Concluído
🇫🇷 França
NCT02329509 · Evaluation of Facial Growth in Two Primary Protocols Used in…Concluído
NA
NCT03976609 · Three Dimensional Changes on Nasal Septum and Alveolar Cleft…Concluído
NCT00829101 · Articulation and Phonology in Children With Unilateral Cleft…Concluído
🇸🇪 Suécia
NCT00760006 · Preventing Complications in Cleft Palate Repair With Antibio…Concluído
PHASE2🇺🇸 Estados Unidos
NCT00773994 · Pilot Study Evaluating Characteristic Closure Patterns of th…Concluído
NA🇺🇸 Estados Unidos
NCT00584272 · Retrospective Study on the Outcome of Cleft Palate Repair: C…Concluído
🇺🇸 Estados Unidos
NCT01380171 · Primary Palatoplasty in Pediatric Patients - A Retrospective…Concluído
🇺🇸 Estados Unidos
NCT01046591 · Sleep and Behavior in Children With Cleft PalateConcluído
🇺🇸 Estados Unidos
NCT00397917 · Oral Cleft Prevention ProgramConcluído
PHASE3🇺🇸 Estados Unidos
NCT00423072 · Middle Ear Pressure Disregulation in Cleft Palate PatientsConcluído
🇺🇸 Estados Unidos
NCT00405262 · A Comparison of Bupivacaine and Ketorolac for Postoperative …Concluído
PHASE3🇨🇦 Canadá
NCT04972370 · A Proposal for a New Classification of Secondary Cleft Lip a…Concluído
NCT00386269 · Double Blind Randomized Study Into the Efficacy of Codeine P…Concluído
PHASE4🇬🇧 Reino Unido
NCT00001721 · Study of Smith-Lemli-Opitz SyndromeConcluído
🇺🇸 Estados Unidos
NCT00340977 · Svangerskap, Arv, Og Miljo (Pregnancy, Heredity and Environm…Concluído
🇳🇴 Noruega
NCT04354116 · MARPE in Patients With Cleft Lip and PalateUNKNOWN
NA🇧🇷 Brasil
NCT06738927 · Otological Study of Facial Cleft Patients Over 10 Years of A…UNKNOWN
🇫🇷 França
NCT06589453 · Evaluation of Nasal Elevator Versus Grayson's Nasal Stent wi…UNKNOWN
PHASE1
Ver todos no ClinicalTrials.gov
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Publicações mais relevantes

Timeline de publicações
5.949 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 5.949

#1

Anaesthetic management of a paediatric patient with Goldenhar syndrome for oral rehabilitation and palatoplasty.

BMJ case reports2026 Mar 23

Este artigo destaca a complexidade da anestesia para palatoplastia em um paciente pediátrico com Síndrome de Goldenhar, que apresenta desafios significativos na via aérea e ventilação devido a deformidades craniofaciais. Para médicos, o caso enfatiza a importância crucial de uma avaliação pré-operatória minuciosa e um planejamento anestésico individualizado, focando na via aérea e em estratégias de ventilação protetora, para antecipar e reduzir riscos. Para pacientes e suas famílias, demonstra que, com um planejamento cuidadoso e especializado, cirurgias complexas podem ser realizadas com sucesso e segurança, minimizando complicações.

🇧🇷 traduzido
#2

Midline congenital upper lip sinus: a rare clinical case with analytical review of diagnostic and therapy strategies.

Frontiers in pediatrics2026

Este artigo aborda o seio congênito mediano do lábio superior, uma malformação extremamente rara que se manifesta como uma pequena abertura no lábio, da qual pode sair secreção esbranquiçada. Embora seja uma condição isolada na maioria dos casos, é importante que médicos e pacientes saibam que, em algumas raras situações, ela pode estar associada a outras anomalias faciais, como a fissura palatina. Portanto, o artigo destaca a necessidade de um diagnóstico preciso e uma avaliação completa para garantir as melhores estratégias de tratamento.

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#3

Acetylation-triggered degradation of MSX1 impairs palatal development.

Cell death discovery2026 Mar 19

Este estudo identifica a acetilação excessiva da proteína MSX1 como um fator chave na formação da fissura palatina, ao provocar a sua degradação e a morte de células essenciais para o desenvolvimento do palato. Crucialmente, a pesquisa demonstrou que a administração da enzima SIRT1 ou de uma versão modificada da proteína MSX1 pode reduzir significativamente a gravidade da fissura, indicando um promissor potencial preventivo e terapêutico para pacientes.

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#4

Toward Understanding the Role of miRNAs in Cleft Palate Only: Observations from Patient Tissues and In Vitro Assays.

International journal of molecular sciences2026 Feb 24

Este estudo identificou que microRNAs (pequenas moléculas reguladoras) estão significativamente desregulados no tecido de pacientes com fenda palatina isolada (CPO). Especificamente, observou-se a alteração de miR-205-5p, miR-200c-3p e miR-125a-5p, que impactam genes como o PAX9, fundamentais para o desenvolvimento do palato. Essas descobertas fornecem uma compreensão mais profunda dos mecanismos moleculares da CPO, abrindo caminho para novas pesquisas sobre suas causas e, futuramente, para potenciais estratégias terapêuticas.

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#5

Association of prenatal exposure to polychlorinated biphenyls with cleft lip and/or palate risk in offspring: A case-control study.

Journal of environmental sciences (China)2026 Apr

Este estudo pioneiro revelou uma associação significativa entre a exposição pré-natal a bifenilos policlorados (PCBs), poluentes ambientais que podem atravessar a placenta, e um maior risco de lábio leporino e/ou fenda palatina (CL/P) em crianças. Para pacientes e profissionais de saúde, estes resultados alertam sobre a importância de minimizar a exposição a esses químicos durante a gravidez e reforçam a necessidade urgente de intensificar os esforços para remediar ambientes contaminados, visando proteger a saúde materno-infantil.

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Publicações recentes

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📚 EuropePMC6.772 artigos no totalmostrando 200

2026

Anaesthetic management of a paediatric patient with Goldenhar syndrome for oral rehabilitation and palatoplasty.

BMJ case reports
2026

Silent complexity: a rare combination of polysplenia, cleft palate, retroaortic renal vein, and dorsal pancreatic agenesis.

Pediatric radiology
2026

Longitudinal Speech Outcomes in Foreign-Born and Native-Born Children in Sweden with Cleft Palate, and Influence of Palatal Surgery Timing.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

The Relationship Between Parent and Child Anxiety: Testing the Intergenerational Model of Anxiety in Children Born with a Cleft.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Midline congenital upper lip sinus: a rare clinical case with analytical review of diagnostic and therapy strategies.

Frontiers in pediatrics
2026

Acetylation-triggered degradation of MSX1 impairs palatal development.

Cell death discovery
2026

Prenatal Fentanyl Exposure Association With Characteristic Neonatal Anomalies.

Journal of addiction medicine
2026

Orthognathic Surgery for Cleft-Related Maxillomandibular Discrepancies.

Oral and maxillofacial surgery clinics of North America
2026

Management of Cleft-Related Speech Differences.

Oral and maxillofacial surgery clinics of North America
2026

Distinct Involvement of X-Inactivation in Organogenesis.

Journal of dental research
2026

Enhanced Recovery After Surgery Protocols Can Vastly Decrease Rates of Outpatient Opiate Prescribing in Pediatric Plastic Surgery Patients.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Does the Rigid External Distraction Device Allow for Long-Term Control of Maxillary Pitch in Cleft Maxillary Distraction?

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Cleft Lip and Palate is Common in PORCN-Related Focal Dermal Hypoplasia in Asians: Three New Case Reports and Literature Review.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Toward Understanding the Role of miRNAs in Cleft Palate Only: Observations from Patient Tissues and In Vitro Assays.

International journal of molecular sciences
2026

Corrigendum to "Accuracy of cephalometric landmark identification by artificial intelligence platform versus expert orthodontist in unilateral cleft palate patients: A retrospective study" [Int Orthod. 23 (2025) 100990].

International orthodontics
2026

Facial-palate correlation in unilateral cleft lip and palate: A data-driven 3D analysis.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
2026

What We Learnt in Unilateral Cleft Lip Repair Between Millard's and Tennison-Randall's Techniques: Comparison of the Outcomes in Adult Patients.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

What Are the Challenges Facing Comprehensive Cleft Care in Africa? A Qualitative Study Involving Cleft Care Providers Across Africa.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Suprazygomatic Maxillary Nerve Block is Associated with Reduced Postoperative Inpatient Opioid Requirement in Patients Undergoing Palatoplasty.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Comparison of Dental Relationship and Craniofacial Development in Children With Unilateral Cleft Lip and Palate Treated With/Without Presurgical Nasoalveolar Molding.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

A prospective study of the medial cleft edge as a cause of soft palate shortening and a simple technique to restore length during palatoplasty.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2026

A Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders.

Experimental dermatology
2026

Timing of middle ear normalization after furlow palatoplasty vs. intravelar veloplasty.

International journal of pediatric otorhinolaryngology
2026

Impact of Quad-Helix Expansion and Bone Grafting on Speech in Children With Unilateral Cleft Lip and Palate.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
2026

Prevalence of Malnutrition in Children with Cleft Conditions in Madagascar: A Cross-Sectional Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Ultra-low-dose cone-beam CT for cleft and craniofacial deformity surgery: radiation reduction and clinical applicability.

Maxillofacial plastic and reconstructive surgery
2026

Evaluating ChatGPT in Pediatric Craniofacial Surgery Counseling: A Vignette-Based Assessment of Educational Quality, Specificity, Readability, and Emotional Content.

The Journal of craniofacial surgery
2026

Do Patients With Cleft Lip and Palate Have an Increased Risk of Short-Term Complications After Le Fort I Osteotomy?

The Journal of craniofacial surgery
2026

Simultaneous Orthognathic Surgery and Costal Bone Grafting in Hemifacial Microsomia: A Rare Case Report and Literature Review.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Special Issue Introduction: 2026 Spotlight on Early-Career Researchers of the American Cleft Palate-Craniofacial Association.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Retinal detachment in patients with Sticklers syndrome: A comprehensive analysis for craniofacial surgeons.

JPRAS open
2026

Long term speech outcome post cleft palate repair in Kenya: Literature review.

JPRAS open
2026

Association of prenatal exposure to polychlorinated biphenyls with cleft lip and/or palate risk in offspring: A case-control study.

Journal of environmental sciences (China)
2026

Comparative Evaluation of Sella Turcica Morphology and Dimensions in Skeletal Class III Malocclusion and Cleft Lip and Palate Patients Versus Class I Individuals.

Clinical and experimental dental research
2026

Morphological Changes Occur in the Brains of Children With Non-Syndromic Cleft Lip and Palate After Speech Therapy.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Screening for Obstructive Sleep Apnoea in Patients With Cleft Lip and/or Palate in Saudi Arabia.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

MEK1/2 Inhibitor (U0126) and PI3K Inhibitor (LY294002) Suppress Herpes Simplex Virus Type 1 Replication by Targeting MAPK/ERK1/2 and PI3K/AKT Signaling Pathways: Implications for Oral Health and Translational Control of Orolabial HSV-1 Infection.

Iranian journal of pharmaceutical research : IJPR
2026

Morphometric Findings in Adolescents with Robin Sequence: A Photographic and Cephalometric Study of the Face and Mandible.

Children (Basel, Switzerland)
2026

Otopalatodigital Syndrome Type 2: A Case Report.

Neonatal network : NN
2026

Comparison of dentofacial changes after orthognathic surgery in adults with unilateral cleft lip and palate and isolated cleft palate.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
2026

Does Palatoplasty in Patients with Cleft Palate Really Improve Otitis Media with Effusion?

Dentistry journal
2026

Orofacial clefting in PHF6-related Börjeson-Forssman-Lehmann syndrome.

BMJ case reports
2026

Impact of perioperative circumstances on postoperative respiratory complications in cleft lip and palate patients undergoing palatoplasty.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
2026

Comprehensive Smile Component Analysis in Unilateral Cleft Lip and Palate Using Akhter-Anne Framework.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Cephalometric Comparison of Le Fort I Osteotomy in Growing and Non-Growing Patients With Clefts: A Retrospective Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Disparities in Cleft Care for Hispanic/Latino Patients in the United States: A Systematic Review and Meta-Analysis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Orofacial Cleft Disparities in American Indian and Alaska Native Populations: A Systematic Review and Meta-Analysis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Risk Factors for Infection, Dehiscence, and Unplanned Reintubation Following Cleft Lip Repair.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Levator Veli Palatini Reconstruction Using an Autologous Tendon Graft in Velopharyngeal Insufficiency: What I Do.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Skeletal Facial Patterns in Cleft Lip and/or Palate: A Cross-Sectional Study in a Brazilian Craniofacial Center.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

A Novel Association Between Mandibulofacial Dysostosis with Microcephaly and Congenital Diaphragmatic Hernia.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

The Use of Infrared Thermal Imaging for Real-Time Flap Perfusion in Revision Palatoplasty with Buccinator Myomucosal Flaps.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Velopharyngeal Insufficiency Effects on Life Outcome Scores and Decision-Making for Secondary Speech Surgery after Palatoplasty.

Plastic and reconstructive surgery
2026

Peripartum Management of Refractory Graves' Thyrotoxicosis.

Cureus
2026

Advanced Strategies in the Repair of Alveolar Cleft Defects: Biological Approaches, Biomaterials, and Future Perspectives.

Progress in molecular and subcellular biology
2026

Survey of Practice Patterns of Maxillary Distraction Osteogenesis Among Craniofacial Surgeons in Patients With Cleft Lip and Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

The Influence of Fluidic Flow Stress on the Development of the Secondary Palate.

Journal of developmental biology
2026

Integrated Phosphoproteomics Identifies TGFβ-Dependent Phosphorylation Events Linking Kinase Signaling to Autophagy in Palatogenesis.

Proteomes
2026

Fetal Cleft Lip and Palate.

Obstetrics and gynecology
2026

Exploring Sleep Behavior and Language Outcomes in Children with Cleft Lip and Palate Using Data from a National Cohort Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Expanding the Phenotype of TAB2-Related Syndrome: The First Case With Cleft Palate and Insights Into Palatal Development.

American journal of medical genetics. Part A
2026

Expansion of the 3MC Syndrome Spectrum: Novel COLEC10 Variants and a MASP1 Exon-Level Deletion.

American journal of medical genetics. Part A
2026

A Comparative Study of Cleft Management in Different Economic Settings: United States Versus Guatemala.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Comparison on the Success of Secondary Alveolar Bone Grafting Performed Below 12 Years and On or After 12 Years of Age for Patients With Cleft Alveolus: A Systematic Review and Meta-Analysis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Identification of Cost Categories of Cleft Care Incurred by the Parent and Child from Birth to Adulthood in the United Kingdom.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Corrigendum to "Neuroendocrine Axis Investigation in Patients with Arhinia, Hemiarhinia and Associated Malformations".

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

The Impact of Socioeconomic Deprivation on Timing and Long-Term Outcomes of Cleft Surgery: A 30-Year Retrospective Analysis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Rate of fistula repair following palatoplasty in patients with cleft lip and palate: A systematic review of the literature.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2026

Advances in genetic mechanisms and precision medicine research for cleft lip and palate.

Gene
2026

Globalizing Cleft Orthognathic Surgery: Technical Guidance and a Multidisciplinary Roadmap.

Annals of plastic surgery
2026

Anesthetic Considerations for Cleft Lip and Palate Surgery.

Annals of plastic surgery
2026

Impact of Medicaid Expansion on State-Level Medicaid Reimbursement for Orthodontia in Patients With Cleft Lip and Palate: A Cost Analysis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Treatment and Long-Term Outcomes of Children with Co-Occurring Childhood Apraxia of Speech and Velopharyngeal Dysfunction.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Construct Validity of Japanese Version of CLEFT-Q: Cleft-Specific Patient-Reported Outcomes Questionnaire.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Multidisciplinary Care Considerations for Children with Facial Clefts.

Oral and maxillofacial surgery clinics of North America
2026

Helmet Therapy in Infants with Positional Skull Deformity: A Retrospective Study of 455 Patients from a German Tertiary Care Center.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Leveraging the genetics of human face shape boosts the discovery of orofacial cleft risk loci.

medRxiv : the preprint server for health sciences
2026

Permanent maxillary canine eruption in children with clefts - a retrospective study.

Acta odontologica Scandinavica
2026

A cost analysis of speech-language pathology applications for telepractice during the COVID-19 pandemic.

BMC health services research
2026

Clinical and genetic characterization of patients with Digeorge syndrome: a single-center, first report from Sudan.

BMC pediatrics
2026

Behind the Screens-Social Media and Psychosocial Outcomes in Adolescents With Cleft Lip/Palate.

Annals of plastic surgery
2026

LIMA Protocol for Palatal Fistula Reduction and Early Postoperative Maxillary Morphology in Unilateral Cleft Lip and Palate: A Randomized Controlled Trial.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

IRF6 Gene Polymorphisms Influence the Susceptibility of Nonsyndromic Cleft Lips With or Without Palate: A MOOSE-Compliant Meta-Analysis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Addressing Competence and Educational Gaps Among Speech and Language Pathologists in Cleft Palate Care: A Cross-Sectional Study in Flanders.

International journal of language &amp; communication disorders
2026

The Most Efficient Surgical Technique to Treat Velopharyngeal Insufficiency After Primary Cleft Palate Repair: A Systematic Review and Meta-Analysis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

A Technique for Repositioning the Posteriorly Displaced Premaxilla Following Prior Repair of Complete Bilateral Cleft Lip.

Plastic and reconstructive surgery. Global open
2026

Loss of SPECC1L in cranial neural crest cells results in increased hedgehog signaling and frontonasal dysplasia.

Frontiers in physiology
2026

Timing of Secondary Palate Fusion in Human Embryos and Fetuses.

Birth defects research
2026

Collaboration begins with connection: Experiences of community-based speech-language pathologists in cleft palate continuity of care.

International journal of speech-language pathology
2026

Effects of Rapid Maxillary Expansion on Upper Airway Parameters in Children With Unilateral Cleft Lip and Palate: A Cone-Beam Computed Tomography (CBCT) Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Perceptions of Interdisciplinary Cleft Treatment: A Qualitative Pilot Study of Children With Cleft Palate and Their Parents.

International journal of language &amp; communication disorders
2026

Characterizing Secondary Velopharyngeal Surgery in Children With Cleft Palate at an Academic Center.

The Laryngoscope
2026

Academic achievement in children with orofacial clefts: A nationwide study in Sweden.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2026

Does a TEOAE refer / AABR pass profile at the neonatal hearing screening indicate risk?

International journal of pediatric otorhinolaryngology
2026

Understanding Appearance Concerns in Young People With Cleft Lip ± Palate: A Photo Elicitation Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Minor modification of soft palate surgical technique resulted in a considerable increase of residual cleft dimensions for unilateral cleft lip and palate.

Journal of plastic surgery and hand surgery
2026

Predictive Capabilities of the Asher-McDade Esthetic Index for Nasolabial Revision Surgery: A Pilot Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Timing Matters? Investigating the Impact of Age at Palatal Closure on Hearing in Filipino Individuals with Cleft Palate.

Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)
2026

Incidence of Ocular Abnormalities in Metopic Craniosynostosis: Cranial Vault Reconstruction Versus Endoscopic Suturectomy.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Demography and Surgical Interventions of Submucous Cleft Palate: A Single-center Retrospective Case Series.

Journal of plastic and reconstructive surgery
2026

Case Reviews for Two Families With Unique Variants in TBX22 Causing Abruzzo-Erickson Syndrome.

American journal of medical genetics. Part A
2026

Temporomandibular joint morphology in cleft lip and palate: evidence from a CBCT-based volumetric analysis.

BMC oral health
2026

Development of a zebrafish model of Loeys-Dietz syndrome through tgfbr2b knockdown.

Journal of human genetics
2026

Three-Dimensional Evaluation of the Maxillary Sinus in Unrepaired Adult Patients With Isolated Cleft Palate Using Cone-Beam Computed Tomography.

The Journal of craniofacial surgery
2026

Perfluorohexanesulfonic acid-induced inhibition of human palate cell proliferation through upregulation of miR-374a-5p.

Biomedical research (Tokyo, Japan)
2025

Comparison of treatment duration and complications between surgery-first and conventional orthognathic approaches: a retrospective study.

European journal of orthodontics
2026

Comparative analysis of knowledge and attitude regarding Naso-alveolar molding protocols in cleft care: insights from dental specialties.

BMC oral health
2026

Speaking Up: Communication Rights and the Lived Experiences of Children With Cleft Palate.

Language, speech, and hearing services in schools
2025

Cleft Lip and Palate: Overview of Causes, Surgical Repair, and Treatment Approaches: A Narrative Review.

World journal of plastic surgery
2026

Evaluation of Orbitomalar Region Projection İn Patients With Operated Cleft Lip and Palate Part 2: Effect of Maxillary Position.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Virtual Surgical Planning (VSP) in Orthognathic Surgery for Non-Syndromic Cleft Patients: A Scoping Review of Trends and Clinical Outcomes.

Journal of clinical medicine
2025

Digital Technologies in Diagnosing Solitary Median Maxillary Central Incisor Syndrome.

Children (Basel, Switzerland)
2026

Early maxillary arch development in unilateral cleft lip and palate: a retrospective 3D morphometric analysis following nasoalveolar molding and cheiloplasty.

BMC oral health
2026

Prophylactic Antibiotic Therapy in Cleft Surgery-A Scoping Review.

Dentistry journal
2026

Comparing Accuracy and Completeness of Google Search Versus ChatGPT-4 Responses to Questions Patients Have Regarding Common Craniofacial Conditions.

Annals of plastic surgery
2026

Analysis of the Chief Complaints at Consultation in 278 Patients With Submucous Cleft Palate.

The Journal of craniofacial surgery
2025

Parental knowledge and barriers to cleft lip and palate care: a cross-cultural study from the Middle East and South Asia.

Frontiers in public health
2025

Bone-on-Bone Telescopic Fixation With Step-Plate Stabilization: A Novel Approach for Enhanced Stability in LeFort I Maxillary Advancement for Cleft-Related Hypoplasia.

Cureus
2026

The "Dynamic Tongue Contraction Technique" for Diagnosis of Soft Palate Cleft in Cases of Cleft Lip and Palate Sequence.

Prenatal diagnosis
2026

Double-Opposing Z-Plasty for Velopharyngeal Insufficiency: Technical Advancements and Outcomes.

Annals of plastic surgery
2026

Multisystem Comorbidities Associated With Orofacial Dysfunction in the Appalachian Region: A Retrospective Analysis.

Plastic and reconstructive surgery. Global open
2026

Weight Gain in Infants With Pierre Robin Sequence: A Comparison of Nonsurgical Orthodontic Airway Plate Versus Surgical Mandibular Distraction Osteogenesis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Factor Affecting the Receiving Repeated Ventilation Tube Insertion in Children With Cleft Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Tissue Adhesive Versus Sutures for Skin Closure in Primary Cleft Lip Repair: A Systematic Review and Meta-Analysis.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Standardized Method for Description of Cleft Lip and Palate Phenotypes and Its Implementation in Daily Practice: Validation Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Dutch and Belgian Workflow for Ventilation Tubes Insertion in Children With Cleft Palate-A Survey Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

A Comparative Study on Vertical and Transverse Orthodontic Relapse in Patients with and Without Cleft Lip and Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Prenatal diagnosis of Blepharo-Cheilo-Dontic syndrome: a case report.

Archives of gynecology and obstetrics
2025

Malformation Pattern and Molecular Findings in the FGFR1-Related Hartsfield Syndrome Phenotype.

Medical sciences (Basel, Switzerland)
2026

Pharyngeal Flap and Sphincter Pharyngoplasty for Velopharyngeal Insufficiency in Cleft Patients: A Systematic Review and Meta-Analysis.

The Journal of craniofacial surgery
2026

Novel variants in STAG2 and PKD1 associate with multiple congenital malformations and autosomal dominant polycystic kidney disease in a Chinese family: A case report and literature review.

Experimental and therapeutic medicine
2026

Orthodontic Appliance-Related Mucosal Ulcerations in Newborns and Infants With Craniofacial Disorders.

Clinical and experimental dental research
2026

Parental knowledge and access barriers in the management of cleft lip and/or palate: A cross-sectional study from Saudi Arabia.

Medicine
2026

Food Security Impacts Health of Children With Orofacial Clefts: An 8-Year Review of the Global Burden of Disease Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Cleft Summit 2023: How NGOs can Promote Development of Sustainable Interdisciplinary Cleft Care.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Visualizing the Timeline of Care: Development of a Graphical Approach to Better Understanding Complex, Longitudinal Surgical Care of Cleft Lip/Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Comparative analysis of soft tissue response after orthognathic surgery in patients with and without cleft using 3D imaging: A preliminary study.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
2026

Bilateral orofacial clefts are associated with increased risk of psychiatric morbidity relative to unilateral clefts.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2026

The unfinished journey: A narrative review of inequities in secondary cleft lip and palate care in low- and middle-income countries.

Tropical doctor
2026

Structural birth defects and exposure to oil and gas wells during pregnancy.

Pediatric research
2025

Comparison of the nasal complex in individuals with and without cleft lip and palate using cone-beam computed tomography.

Imaging science in dentistry
2026

The role of Rho GTPases in facial morphogenesis.

Developmental dynamics : an official publication of the American Association of Anatomists
2026

Pleiotropic genes linking congenital hypogonadotropic hypogonadism and cleft lip/palate: evidence from a genomic CHH cohort study.

European journal of human genetics : EJHG
2026

Buccinator myomucosal flap with rotational flap in repair of midline and distal palatal Fistulas: A comparative study of 30 cases with speech outcome evaluation.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
2026

Descriptive Exploration of Features Among Infants With Prenatal Fentanyl Exposure in a Multisite Cohort of Maternal-Infant Dyads Affected by Opioid Use Disorder.

Journal of addiction medicine
2026

'This is the Test of Our Faith': An Exploratory Study of the Religio-spiritual and Cultural Construction of Cleft Lip and Palate Among Muslim Parents in Punjab, Pakistan.

Journal of religion and health
2025

Craniofacial features associated with Hutchinson - Gilford progeria syndrome - A case report.

Stomatologija
2025

Etiological Factors of Orofacial Clefts in a Hospital-Based Population: A Descriptive Analytical Study.

Cureus
2026

Long-Term Velopharyngeal Insufficiency-Related Quality of Life in Cleft Palate Patients: Speech and Surgical Factors.

International dental journal
2026

Prevalence and risk factors of cleft lip and/or palate in Ethiopia: A systematic review and meta-analysis.

Journal of stomatology, oral and maxillofacial surgery
2026

The association between paternal race and ethnicity and a spectrum of birth defects in a national case-control study.

Annals of epidemiology
2026

Out of the Laboratory and Into the Clinic: Out-of-Domain Validation of Machine Learning Models for Velopharyngeal Dysfunction Detection.

Annals of plastic surgery
2026

Examining Sociodemographic Disparities in Diagnostic Delays and Surgical Management of Non-Syndromic Craniosynostosis: A 10-Year Review.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Subcutaneous Emphysema Following Tracheocutaneous Fistula Closure in a Pediatric Patient: A Case Report.

Cureus
2026

Laterality and Completeness Patterns of Nonsyndromic Clefts in a Multiethnic Cohort.

medRxiv : the preprint server for health sciences
2025

rs2033806 at PAX3 Gene Associated with Non-syndromic Oral Cleft among the Chinese Population.

The Chinese journal of dental research
2026

The Suggestive Association Between the NOG rs227731 Polymorphism and Non-Syndromic Cleft Lip With or Without Palate Subtypes in a Japanese Cohort.

Congenital anomalies
2025

Comparison of palatal lengthening and perioperative outcomes of Furlow's Z-plasty versus von Langenbeck's palatoplasty in children with complete, non-syndromic cleft palate: a randomized controlled trial in India.

Archives of craniofacial surgery
2026

Prenatally Diagnosed 7q11.23 Copy Number Variations: A Retrospective Case Series.

Molecular genetics &amp; genomic medicine
2026

Surgical management and outcomes of recurrent palatal fistulae: Insights from CLAPP's institutional experience.

Journal of plastic, reconstructive &amp; aesthetic surgery : JPRAS
2025

[Early diagnosis of congenital craniofacial differences: a systematic review of current evidence].

Revista cientifica odontologica (Universidad Cientifica del Sur)
2026

Barriers and delays in access to cleft surgery among children with cleft deformities in Rwanda: a qualitative study.

BMJ open
2026

Buccal Sulcus Myomucosal Flap-an Approach for the Closure of Anterior Palatal Fistulae: A Retrospective Cohort Analysis of 132 Patients.

Annals of plastic surgery
2025

Associated congenital malformations, syndromes, and medical conditions in patients with orofacial clefts: a 10-year hospital-based study in Thailand.

Frontiers in oral health
2026

A history of the shared airway: anaesthesia in ENT.

The Journal of laryngology and otology
2026

3D-Printed Models in Oral Surgery Simulation Training: A Scoping Review.

Journal of dental education
2025

Do Pharyngeal Flaps Have a Greater Risk of Obstructive Sleep Apnea Than Other Speech Procedures? A Systematic Review and Meta-Analysis.

Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
2025

Dental anomalies in subjects with non-syndromic cleft lip and palate.

Stomatologija
2026

Detectable AI-Generated Text in the Journal of Craniofacial Surgery : A Comparison of 2014 and 2024 Publications.

The Journal of craniofacial surgery
2025

[Research progress on regulatory variants in non-coding regions in non-syndromic cleft lip with or without cleft palate].

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
2025

Different Characteristics of Maxillary Development and Bone Defect: An Observation from Unilateral Cleft Lip Patients With Complete and Incomplete Cleft Palate.

The Journal of craniofacial surgery
2026

Predictors of Vocabulary and Morphosyntax Ability in 2-Year-Old Children with Repaired Cleft Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Advancing Prediction of Secondary Speech Surgery After Palatoplasty.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Three-Dimensional Evaluation of Secondary Alveolar Bone Grafting in Patients With Bilateral Cleft Lip and/or Palate: A 2-3-Year Post-Operative Follow-Up.

Orthodontics &amp; craniofacial research
2025

Expanding the Genetic Spectrum of Non-Syndromic Cleft Lip and Palate Through Whole-Exome Sequencing.

International journal of molecular sciences
2025

Exploring Current Trends, Challenges and Future Directions of Intraoral Digital Impression in the Management of Patients with Cleft Lip and/or Palate: A Narrative Literature Review.

Children (Basel, Switzerland)
2025

Successful Premaxillary Reconstruction and Oronasal Fistula Closure in a Patient With VATER Syndrome With Bilateral Cleft and Missing Premaxilla.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Effect of Language Interpreter Modalities on Patient Satisfaction and Clinical Workflow: A Pilot Study in a Multidisciplinary Pediatric Craniofacial Clinic.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Surgical Outcomes of Submucous Cleft Palate Using Intravelar Veloplasty with a Buccinator Musculomucosal Flap: A Case Series.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Assessment of facial asymmetry in patients with orofacial cleft based on the biometric proposal of the average male face.

Clinical oral investigations
2025

Navigating Airway Obstacles: Effective Anesthesia Strategies for Severe Robinson Sequence in a 3 year old.

The Medical journal of Malaysia
2025

Haematological trends and associated congenital anomalies in children with cleft lip and palate.

The Medical journal of Malaysia
2025

Speech outcomes following Le Fort I maxillary advancement in cleft lip and palate patients: A retrospective evaluation using the Borel-Maisonny classification.

Journal of stomatology, oral and maxillofacial surgery
2025

Sustainable Health Programs: Challenges and Pathways to Success.

Annals of plastic surgery
2025

Orthodontic Care Delivery Across ACPA Teams in the US.

Annals of plastic surgery
2025

Orthodontic treatment planning in cleft and craniofacial patients with clear aligners: burden of care and informed consent.

The Journal of forensic odonto-stomatology
2025

Neuroendocrine Axis Investigation in Patients with Arhinia, Hemiarhinia and Associated Malformations.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Agreement Between Hypernasality Ratings and Nasalance Scores in Spanish-English Bilingual Patients with Cleft Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Otitis Media With Effusion in Patients With Cleft Palate.

Clinical pediatrics
2025

[Parent-of-origin effects of FGF/FGFR signaling pathway candidate gene polymorphisms on the risk of non-syndromic cleft lip with or without cleft palate].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi
2025

Audiological Characterization in Children With Isolated Robin Sequence During the First Year of Life: A Retrospective Study.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2026

Buccal Fat Pad Adjunctive Flap During Primary Cleft Palate Repair: Effects on Maxillary Dimensions and Molar Eruption.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

"Barriers to Care Associated with Pediatric Orofacial Clefts Global Disease Burden".

Plastic and reconstructive surgery
2025

Comparative Outcomes of Conventional Bardach Two-Flap Palatoplasty Versus Modified Alveolar Ridge/Crevicular Incision Technique in Isolated Cleft Palate Repair: A Prospective Observational Study.

Cureus
2025

Silver-Russell syndrome secondary to rare (epi)genotypes exhibits phenotypic heterogeneity challenging clinical diagnosis.

Clinical epigenetics
2026

Surgical treatment of 89 patients with craniofacial microsomia in a craniofacial national reference centre in Finland.

Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
2025

Which Prediction Works Best? A 3-Dimensional Evaluation of Mixed Dentition Analysis in Cleft Lip and Palate.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Corrigendum to "Geometric Morphometric Study of ear Shape in Four Chinese Ethnic Minority Populations".

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Morphometric Evaluation of the Pterygomaxillary Suture in Patients with Unilateral and Bilateral Cleft Lip and Palate Using Cone-Beam Computed Tomography.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
2025

Hong Kong and Macao Speech-Language Pathologists' Experiences in the Clinical Practice of Cleft Palate Speech/Velopharyngeal Dysfunction.

The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association
Ver todos os 6.772 no EuropePMC

Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

Ainda não temos associações cadastradas para Fenda palatina.

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Doença com base genética

Um médico geneticista pode ajudar no diagnóstico de Fenda palatina e no aconselhamento genético da família.

Vai consultar um especialista? Confirme o registro dele no conselho.
Conselhos e sociedades

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Perguntas frequentes

O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu

Respostas geradas por IA a partir das fontes citadas

A fenda palatina tem causa multifatorial e poligênica, envolvendo fatores biológicos e genéticos durante a gestação. Dentre os fatores genéticos identificados, há alterações documentadas em genes como TBX22, GRHL3, TP63 e UBB.

Referências

Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete

10 publicações do grafo RarasNet (PubMed) · 5 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.

  1. ORPHA:2014
    Orphanet
  2. Q27677677
    Wikidata

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Citar este verbete

Raras. (s.d.). Fenda palatina. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/fenda-palatina

Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Compêndio · Raras BR

Fenda palatina

ORPHA:2014 · MONDO:0016064
🇧🇷 Brasil SUS
SIGTAP
5 procedimentos
Geral
Prevalência
1-5 / 10 000
Herança
Multigenic/multifactorial, Not applicable
CID-10
Q35 · Fenda palatina
CID-11
Ensaios
29 ativos
Início
Antenatal, Neonatal
Prevalência
0.0 (Europe)
MedGen
UMLS
C1837218
EuropePMC
Wikidata
Papers 10a

📋 Origem dos dados

Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.

Doença rara (ontologia)
fonte: Orphanet
Identificador unificado
fonte: MONDO
Indexação biomédica
fonte: MeSH (NLM)
Dado público estruturado
fonte: Wikidata
Rara