A fenda palatina é uma embriopatia do tipo fissura que afeta o palato mole e duro em graus variados.
Introdução
O que você precisa saber de cara
A fenda palatina é uma embriopatia do tipo fissura que afeta o palato mole e duro em graus variados.
Escala de raridade
<1/50kMuito rara
1/20kRara
1/10kPouco freq.
1/5kIncomum
1/2k
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
Partes do corpo afetadas
+ 19 sintomas em outras categorias
Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 72 características clínicas mais associadas, ordenadas por frequência.
Linha do tempo da pesquisa
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Genética e causas
O que está alterado no DNA e como passa nas famílias
Genes associados
4 genes identificados com associação a esta condição. Padrão de herança: Multigenic/multifactorial, Not applicable.
Probable transcriptional regulator involved in developmental processes. This is major determinant crucial to palatogenesis
Nucleus
Cleft palate with or without ankyloglossia, X-linked
A congenital mouth abnormality characterized by fissure of the soft and/or hard palate, due to faulty fusion. Some patients also manifest ankyloglossia, a condition in which movements of the tongue are restricted. Complete ankyloglossia is due to fusion between the tongue and the floor of the mouth. Partial ankyloglossia is due to a short lingual frenum or one which is attached too near the tip of the tongue.
Transcription factor playing important roles in primary neurulation and in the differentiation of stratified epithelia of both ectodermal and endodermal origin (By similarity). Binds directly to the consensus DNA sequence 5'-AACCGGTT-3' acting as an activator and repressor on distinct target genes (PubMed:21081122, PubMed:25347468). xhibits functional redundancy with GRHL2 in epidermal morphogenetic events and epidermal wound repair (By similarity). Exhibits functional redundancy with GRHL2 in e
Nucleus
Van der Woude syndrome 2
An autosomal dominant developmental disorder characterized by lower lip pits, cleft lip and/or cleft palate.
Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiqui
CytoplasmNucleusMitochondrion outer membrane
Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG
Nucleus
Acro-dermato-ungual-lacrimal-tooth syndrome
A form of ectodermal dysplasia. Ectodermal dysplasia defines a heterogeneous group of disorders due to abnormal development of two or more ectodermal structures. ADULT syndrome involves ectrodactyly, syndactyly, finger- and toenail dysplasia, hypoplastic breasts and nipples, intensive freckling, lacrimal duct atresia, frontal alopecia, primary hypodontia and loss of permanent teeth. ADULT syndrome differs significantly from EEC3 syndrome by the absence of facial clefting. Inheritance is autosomal dominant.
Variantes genéticas (ClinVar)
233 variantes patogênicas registradas no ClinVar.
Classificação de variantes (ClinVar)
Distribuição de 226 variantes classificadas pelo ClinVar.
Vias biológicas (Reactome)
44 vias biológicas associadas aos genes desta condição.
Diagnóstico
Os sinais que médicos procuram e os exames que confirmam
Tratamento e manejo
Remédios, cuidados de apoio e o que precisa acompanhar
Onde tratar no SUS
Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)
🇧🇷 Atendimento SUS — Fenda palatina
Selecione um estado ou use sua localização para ver resultados.
Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.
Pesquisa ativa
Ensaios clínicos abertos e novidades científicas recentes
Ensaios em destaque
🟢 Recrutando agora
20 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.
Outros ensaios clínicos
Publicações mais relevantes
Mostrando amostra de 200 publicações de um total de 5.949
Anaesthetic management of a paediatric patient with Goldenhar syndrome for oral rehabilitation and palatoplasty.
Este artigo destaca a complexidade da anestesia para palatoplastia em um paciente pediátrico com Síndrome de Goldenhar, que apresenta desafios significativos na via aérea e ventilação devido a deformidades craniofaciais. Para médicos, o caso enfatiza a importância crucial de uma avaliação pré-operatória minuciosa e um planejamento anestésico individualizado, focando na via aérea e em estratégias de ventilação protetora, para antecipar e reduzir riscos. Para pacientes e suas famílias, demonstra que, com um planejamento cuidadoso e especializado, cirurgias complexas podem ser realizadas com sucesso e segurança, minimizando complicações.
🇧🇷 traduzidoMidline congenital upper lip sinus: a rare clinical case with analytical review of diagnostic and therapy strategies.
Este artigo aborda o seio congênito mediano do lábio superior, uma malformação extremamente rara que se manifesta como uma pequena abertura no lábio, da qual pode sair secreção esbranquiçada. Embora seja uma condição isolada na maioria dos casos, é importante que médicos e pacientes saibam que, em algumas raras situações, ela pode estar associada a outras anomalias faciais, como a fissura palatina. Portanto, o artigo destaca a necessidade de um diagnóstico preciso e uma avaliação completa para garantir as melhores estratégias de tratamento.
🇧🇷 traduzidoAcetylation-triggered degradation of MSX1 impairs palatal development.
Este estudo identifica a acetilação excessiva da proteína MSX1 como um fator chave na formação da fissura palatina, ao provocar a sua degradação e a morte de células essenciais para o desenvolvimento do palato. Crucialmente, a pesquisa demonstrou que a administração da enzima SIRT1 ou de uma versão modificada da proteína MSX1 pode reduzir significativamente a gravidade da fissura, indicando um promissor potencial preventivo e terapêutico para pacientes.
🇧🇷 traduzidoToward Understanding the Role of miRNAs in Cleft Palate Only: Observations from Patient Tissues and In Vitro Assays.
Este estudo identificou que microRNAs (pequenas moléculas reguladoras) estão significativamente desregulados no tecido de pacientes com fenda palatina isolada (CPO). Especificamente, observou-se a alteração de miR-205-5p, miR-200c-3p e miR-125a-5p, que impactam genes como o PAX9, fundamentais para o desenvolvimento do palato. Essas descobertas fornecem uma compreensão mais profunda dos mecanismos moleculares da CPO, abrindo caminho para novas pesquisas sobre suas causas e, futuramente, para potenciais estratégias terapêuticas.
🇧🇷 traduzidoAssociation of prenatal exposure to polychlorinated biphenyls with cleft lip and/or palate risk in offspring: A case-control study.
Este estudo pioneiro revelou uma associação significativa entre a exposição pré-natal a bifenilos policlorados (PCBs), poluentes ambientais que podem atravessar a placenta, e um maior risco de lábio leporino e/ou fenda palatina (CL/P) em crianças. Para pacientes e profissionais de saúde, estes resultados alertam sobre a importância de minimizar a exposição a esses químicos durante a gravidez e reforçam a necessidade urgente de intensificar os esforços para remediar ambientes contaminados, visando proteger a saúde materno-infantil.
🇧🇷 traduzidoPublicações recentes
An RCT Evaluating the Efficacy of Using Platelet-Rich Fibrin (PRF) with Conventional Technique of Cleft Palate Repair.
Development and Validation of a Parent-Reported Clinical Screening Instrument for Team Care of Young Children with a Cleft: The CleftChild-8.
From Anatomy to Application: A Developmental Framework for Suprazygomatic Maxillary Nerve Block in Pediatric Palatoplasty.
Associations Between Alcohol Dehydrogenase Mutations and Cleft Lip/Palate: A Scoping Review.
Congenital hypothyroidism with preserved fifth digits in SMARCA4-related Coffin-Siris syndrome: a case report.
📚 EuropePMC6.772 artigos no totalmostrando 200
Anaesthetic management of a paediatric patient with Goldenhar syndrome for oral rehabilitation and palatoplasty.
BMJ case reportsSilent complexity: a rare combination of polysplenia, cleft palate, retroaortic renal vein, and dorsal pancreatic agenesis.
Pediatric radiologyLongitudinal Speech Outcomes in Foreign-Born and Native-Born Children in Sweden with Cleft Palate, and Influence of Palatal Surgery Timing.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationThe Relationship Between Parent and Child Anxiety: Testing the Intergenerational Model of Anxiety in Children Born with a Cleft.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationMidline congenital upper lip sinus: a rare clinical case with analytical review of diagnostic and therapy strategies.
Frontiers in pediatricsAcetylation-triggered degradation of MSX1 impairs palatal development.
Cell death discoveryPrenatal Fentanyl Exposure Association With Characteristic Neonatal Anomalies.
Journal of addiction medicineOrthognathic Surgery for Cleft-Related Maxillomandibular Discrepancies.
Oral and maxillofacial surgery clinics of North AmericaManagement of Cleft-Related Speech Differences.
Oral and maxillofacial surgery clinics of North AmericaDistinct Involvement of X-Inactivation in Organogenesis.
Journal of dental researchEnhanced Recovery After Surgery Protocols Can Vastly Decrease Rates of Outpatient Opiate Prescribing in Pediatric Plastic Surgery Patients.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationDoes the Rigid External Distraction Device Allow for Long-Term Control of Maxillary Pitch in Cleft Maxillary Distraction?
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCleft Lip and Palate is Common in PORCN-Related Focal Dermal Hypoplasia in Asians: Three New Case Reports and Literature Review.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationToward Understanding the Role of miRNAs in Cleft Palate Only: Observations from Patient Tissues and In Vitro Assays.
International journal of molecular sciencesCorrigendum to "Accuracy of cephalometric landmark identification by artificial intelligence platform versus expert orthodontist in unilateral cleft palate patients: A retrospective study" [Int Orthod. 23 (2025) 100990].
International orthodonticsFacial-palate correlation in unilateral cleft lip and palate: A data-driven 3D analysis.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryWhat We Learnt in Unilateral Cleft Lip Repair Between Millard's and Tennison-Randall's Techniques: Comparison of the Outcomes in Adult Patients.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationWhat Are the Challenges Facing Comprehensive Cleft Care in Africa? A Qualitative Study Involving Cleft Care Providers Across Africa.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationSuprazygomatic Maxillary Nerve Block is Associated with Reduced Postoperative Inpatient Opioid Requirement in Patients Undergoing Palatoplasty.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationComparison of Dental Relationship and Craniofacial Development in Children With Unilateral Cleft Lip and Palate Treated With/Without Presurgical Nasoalveolar Molding.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationA prospective study of the medial cleft edge as a cause of soft palate shortening and a simple technique to restore length during palatoplasty.
Journal of plastic, reconstructive & aesthetic surgery : JPRASA Novel Model System to Identify Cellular and Molecular Defects Underlying Rare Genetic Disorders.
Experimental dermatologyTiming of middle ear normalization after furlow palatoplasty vs. intravelar veloplasty.
International journal of pediatric otorhinolaryngologyImpact of Quad-Helix Expansion and Bone Grafting on Speech in Children With Unilateral Cleft Lip and Palate.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial SurgeonsPrevalence of Malnutrition in Children with Cleft Conditions in Madagascar: A Cross-Sectional Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationUltra-low-dose cone-beam CT for cleft and craniofacial deformity surgery: radiation reduction and clinical applicability.
Maxillofacial plastic and reconstructive surgeryEvaluating ChatGPT in Pediatric Craniofacial Surgery Counseling: A Vignette-Based Assessment of Educational Quality, Specificity, Readability, and Emotional Content.
The Journal of craniofacial surgeryDo Patients With Cleft Lip and Palate Have an Increased Risk of Short-Term Complications After Le Fort I Osteotomy?
The Journal of craniofacial surgerySimultaneous Orthognathic Surgery and Costal Bone Grafting in Hemifacial Microsomia: A Rare Case Report and Literature Review.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationSpecial Issue Introduction: 2026 Spotlight on Early-Career Researchers of the American Cleft Palate-Craniofacial Association.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationRetinal detachment in patients with Sticklers syndrome: A comprehensive analysis for craniofacial surgeons.
JPRAS openLong term speech outcome post cleft palate repair in Kenya: Literature review.
JPRAS openAssociation of prenatal exposure to polychlorinated biphenyls with cleft lip and/or palate risk in offspring: A case-control study.
Journal of environmental sciences (China)Comparative Evaluation of Sella Turcica Morphology and Dimensions in Skeletal Class III Malocclusion and Cleft Lip and Palate Patients Versus Class I Individuals.
Clinical and experimental dental researchMorphological Changes Occur in the Brains of Children With Non-Syndromic Cleft Lip and Palate After Speech Therapy.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationScreening for Obstructive Sleep Apnoea in Patients With Cleft Lip and/or Palate in Saudi Arabia.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationMEK1/2 Inhibitor (U0126) and PI3K Inhibitor (LY294002) Suppress Herpes Simplex Virus Type 1 Replication by Targeting MAPK/ERK1/2 and PI3K/AKT Signaling Pathways: Implications for Oral Health and Translational Control of Orolabial HSV-1 Infection.
Iranian journal of pharmaceutical research : IJPRMorphometric Findings in Adolescents with Robin Sequence: A Photographic and Cephalometric Study of the Face and Mandible.
Children (Basel, Switzerland)Otopalatodigital Syndrome Type 2: A Case Report.
Neonatal network : NNComparison of dentofacial changes after orthognathic surgery in adults with unilateral cleft lip and palate and isolated cleft palate.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryDoes Palatoplasty in Patients with Cleft Palate Really Improve Otitis Media with Effusion?
Dentistry journalOrofacial clefting in PHF6-related Börjeson-Forssman-Lehmann syndrome.
BMJ case reportsImpact of perioperative circumstances on postoperative respiratory complications in cleft lip and palate patients undergoing palatoplasty.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryComprehensive Smile Component Analysis in Unilateral Cleft Lip and Palate Using Akhter-Anne Framework.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCephalometric Comparison of Le Fort I Osteotomy in Growing and Non-Growing Patients With Clefts: A Retrospective Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationDisparities in Cleft Care for Hispanic/Latino Patients in the United States: A Systematic Review and Meta-Analysis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationOrofacial Cleft Disparities in American Indian and Alaska Native Populations: A Systematic Review and Meta-Analysis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationRisk Factors for Infection, Dehiscence, and Unplanned Reintubation Following Cleft Lip Repair.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationLevator Veli Palatini Reconstruction Using an Autologous Tendon Graft in Velopharyngeal Insufficiency: What I Do.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationSkeletal Facial Patterns in Cleft Lip and/or Palate: A Cross-Sectional Study in a Brazilian Craniofacial Center.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationA Novel Association Between Mandibulofacial Dysostosis with Microcephaly and Congenital Diaphragmatic Hernia.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationThe Use of Infrared Thermal Imaging for Real-Time Flap Perfusion in Revision Palatoplasty with Buccinator Myomucosal Flaps.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationVelopharyngeal Insufficiency Effects on Life Outcome Scores and Decision-Making for Secondary Speech Surgery after Palatoplasty.
Plastic and reconstructive surgeryPeripartum Management of Refractory Graves' Thyrotoxicosis.
CureusAdvanced Strategies in the Repair of Alveolar Cleft Defects: Biological Approaches, Biomaterials, and Future Perspectives.
Progress in molecular and subcellular biologySurvey of Practice Patterns of Maxillary Distraction Osteogenesis Among Craniofacial Surgeons in Patients With Cleft Lip and Palate.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationThe Influence of Fluidic Flow Stress on the Development of the Secondary Palate.
Journal of developmental biologyIntegrated Phosphoproteomics Identifies TGFβ-Dependent Phosphorylation Events Linking Kinase Signaling to Autophagy in Palatogenesis.
ProteomesFetal Cleft Lip and Palate.
Obstetrics and gynecologyExploring Sleep Behavior and Language Outcomes in Children with Cleft Lip and Palate Using Data from a National Cohort Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationExpanding the Phenotype of TAB2-Related Syndrome: The First Case With Cleft Palate and Insights Into Palatal Development.
American journal of medical genetics. Part AExpansion of the 3MC Syndrome Spectrum: Novel COLEC10 Variants and a MASP1 Exon-Level Deletion.
American journal of medical genetics. Part AA Comparative Study of Cleft Management in Different Economic Settings: United States Versus Guatemala.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationComparison on the Success of Secondary Alveolar Bone Grafting Performed Below 12 Years and On or After 12 Years of Age for Patients With Cleft Alveolus: A Systematic Review and Meta-Analysis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationIdentification of Cost Categories of Cleft Care Incurred by the Parent and Child from Birth to Adulthood in the United Kingdom.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCorrigendum to "Neuroendocrine Axis Investigation in Patients with Arhinia, Hemiarhinia and Associated Malformations".
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationThe Impact of Socioeconomic Deprivation on Timing and Long-Term Outcomes of Cleft Surgery: A 30-Year Retrospective Analysis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationRate of fistula repair following palatoplasty in patients with cleft lip and palate: A systematic review of the literature.
Journal of plastic, reconstructive & aesthetic surgery : JPRASAdvances in genetic mechanisms and precision medicine research for cleft lip and palate.
GeneGlobalizing Cleft Orthognathic Surgery: Technical Guidance and a Multidisciplinary Roadmap.
Annals of plastic surgeryAnesthetic Considerations for Cleft Lip and Palate Surgery.
Annals of plastic surgeryImpact of Medicaid Expansion on State-Level Medicaid Reimbursement for Orthodontia in Patients With Cleft Lip and Palate: A Cost Analysis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationTreatment and Long-Term Outcomes of Children with Co-Occurring Childhood Apraxia of Speech and Velopharyngeal Dysfunction.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationConstruct Validity of Japanese Version of CLEFT-Q: Cleft-Specific Patient-Reported Outcomes Questionnaire.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationMultidisciplinary Care Considerations for Children with Facial Clefts.
Oral and maxillofacial surgery clinics of North AmericaHelmet Therapy in Infants with Positional Skull Deformity: A Retrospective Study of 455 Patients from a German Tertiary Care Center.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationLeveraging the genetics of human face shape boosts the discovery of orofacial cleft risk loci.
medRxiv : the preprint server for health sciencesPermanent maxillary canine eruption in children with clefts - a retrospective study.
Acta odontologica ScandinavicaA cost analysis of speech-language pathology applications for telepractice during the COVID-19 pandemic.
BMC health services researchClinical and genetic characterization of patients with Digeorge syndrome: a single-center, first report from Sudan.
BMC pediatricsBehind the Screens-Social Media and Psychosocial Outcomes in Adolescents With Cleft Lip/Palate.
Annals of plastic surgeryLIMA Protocol for Palatal Fistula Reduction and Early Postoperative Maxillary Morphology in Unilateral Cleft Lip and Palate: A Randomized Controlled Trial.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationIRF6 Gene Polymorphisms Influence the Susceptibility of Nonsyndromic Cleft Lips With or Without Palate: A MOOSE-Compliant Meta-Analysis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationAddressing Competence and Educational Gaps Among Speech and Language Pathologists in Cleft Palate Care: A Cross-Sectional Study in Flanders.
International journal of language & communication disordersThe Most Efficient Surgical Technique to Treat Velopharyngeal Insufficiency After Primary Cleft Palate Repair: A Systematic Review and Meta-Analysis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationA Technique for Repositioning the Posteriorly Displaced Premaxilla Following Prior Repair of Complete Bilateral Cleft Lip.
Plastic and reconstructive surgery. Global openLoss of SPECC1L in cranial neural crest cells results in increased hedgehog signaling and frontonasal dysplasia.
Frontiers in physiologyTiming of Secondary Palate Fusion in Human Embryos and Fetuses.
Birth defects researchCollaboration begins with connection: Experiences of community-based speech-language pathologists in cleft palate continuity of care.
International journal of speech-language pathologyEffects of Rapid Maxillary Expansion on Upper Airway Parameters in Children With Unilateral Cleft Lip and Palate: A Cone-Beam Computed Tomography (CBCT) Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationPerceptions of Interdisciplinary Cleft Treatment: A Qualitative Pilot Study of Children With Cleft Palate and Their Parents.
International journal of language & communication disordersCharacterizing Secondary Velopharyngeal Surgery in Children With Cleft Palate at an Academic Center.
The LaryngoscopeAcademic achievement in children with orofacial clefts: A nationwide study in Sweden.
Journal of plastic, reconstructive & aesthetic surgery : JPRASDoes a TEOAE refer / AABR pass profile at the neonatal hearing screening indicate risk?
International journal of pediatric otorhinolaryngologyUnderstanding Appearance Concerns in Young People With Cleft Lip ± Palate: A Photo Elicitation Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationMinor modification of soft palate surgical technique resulted in a considerable increase of residual cleft dimensions for unilateral cleft lip and palate.
Journal of plastic surgery and hand surgeryPredictive Capabilities of the Asher-McDade Esthetic Index for Nasolabial Revision Surgery: A Pilot Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationTiming Matters? Investigating the Impact of Age at Palatal Closure on Hearing in Filipino Individuals with Cleft Palate.
Folia phoniatrica et logopaedica : official organ of the International Association of Logopedics and Phoniatrics (IALP)Incidence of Ocular Abnormalities in Metopic Craniosynostosis: Cranial Vault Reconstruction Versus Endoscopic Suturectomy.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationDemography and Surgical Interventions of Submucous Cleft Palate: A Single-center Retrospective Case Series.
Journal of plastic and reconstructive surgeryCase Reviews for Two Families With Unique Variants in TBX22 Causing Abruzzo-Erickson Syndrome.
American journal of medical genetics. Part ATemporomandibular joint morphology in cleft lip and palate: evidence from a CBCT-based volumetric analysis.
BMC oral healthDevelopment of a zebrafish model of Loeys-Dietz syndrome through tgfbr2b knockdown.
Journal of human geneticsThree-Dimensional Evaluation of the Maxillary Sinus in Unrepaired Adult Patients With Isolated Cleft Palate Using Cone-Beam Computed Tomography.
The Journal of craniofacial surgeryPerfluorohexanesulfonic acid-induced inhibition of human palate cell proliferation through upregulation of miR-374a-5p.
Biomedical research (Tokyo, Japan)Comparison of treatment duration and complications between surgery-first and conventional orthognathic approaches: a retrospective study.
European journal of orthodonticsComparative analysis of knowledge and attitude regarding Naso-alveolar molding protocols in cleft care: insights from dental specialties.
BMC oral healthSpeaking Up: Communication Rights and the Lived Experiences of Children With Cleft Palate.
Language, speech, and hearing services in schoolsCleft Lip and Palate: Overview of Causes, Surgical Repair, and Treatment Approaches: A Narrative Review.
World journal of plastic surgeryEvaluation of Orbitomalar Region Projection İn Patients With Operated Cleft Lip and Palate Part 2: Effect of Maxillary Position.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationVirtual Surgical Planning (VSP) in Orthognathic Surgery for Non-Syndromic Cleft Patients: A Scoping Review of Trends and Clinical Outcomes.
Journal of clinical medicineDigital Technologies in Diagnosing Solitary Median Maxillary Central Incisor Syndrome.
Children (Basel, Switzerland)Early maxillary arch development in unilateral cleft lip and palate: a retrospective 3D morphometric analysis following nasoalveolar molding and cheiloplasty.
BMC oral healthProphylactic Antibiotic Therapy in Cleft Surgery-A Scoping Review.
Dentistry journalComparing Accuracy and Completeness of Google Search Versus ChatGPT-4 Responses to Questions Patients Have Regarding Common Craniofacial Conditions.
Annals of plastic surgeryAnalysis of the Chief Complaints at Consultation in 278 Patients With Submucous Cleft Palate.
The Journal of craniofacial surgeryParental knowledge and barriers to cleft lip and palate care: a cross-cultural study from the Middle East and South Asia.
Frontiers in public healthBone-on-Bone Telescopic Fixation With Step-Plate Stabilization: A Novel Approach for Enhanced Stability in LeFort I Maxillary Advancement for Cleft-Related Hypoplasia.
CureusThe "Dynamic Tongue Contraction Technique" for Diagnosis of Soft Palate Cleft in Cases of Cleft Lip and Palate Sequence.
Prenatal diagnosisDouble-Opposing Z-Plasty for Velopharyngeal Insufficiency: Technical Advancements and Outcomes.
Annals of plastic surgeryMultisystem Comorbidities Associated With Orofacial Dysfunction in the Appalachian Region: A Retrospective Analysis.
Plastic and reconstructive surgery. Global openWeight Gain in Infants With Pierre Robin Sequence: A Comparison of Nonsurgical Orthodontic Airway Plate Versus Surgical Mandibular Distraction Osteogenesis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationFactor Affecting the Receiving Repeated Ventilation Tube Insertion in Children With Cleft Palate.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationTissue Adhesive Versus Sutures for Skin Closure in Primary Cleft Lip Repair: A Systematic Review and Meta-Analysis.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationStandardized Method for Description of Cleft Lip and Palate Phenotypes and Its Implementation in Daily Practice: Validation Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationDutch and Belgian Workflow for Ventilation Tubes Insertion in Children With Cleft Palate-A Survey Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationA Comparative Study on Vertical and Transverse Orthodontic Relapse in Patients with and Without Cleft Lip and Palate.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationPrenatal diagnosis of Blepharo-Cheilo-Dontic syndrome: a case report.
Archives of gynecology and obstetricsMalformation Pattern and Molecular Findings in the FGFR1-Related Hartsfield Syndrome Phenotype.
Medical sciences (Basel, Switzerland)Pharyngeal Flap and Sphincter Pharyngoplasty for Velopharyngeal Insufficiency in Cleft Patients: A Systematic Review and Meta-Analysis.
The Journal of craniofacial surgeryNovel variants in STAG2 and PKD1 associate with multiple congenital malformations and autosomal dominant polycystic kidney disease in a Chinese family: A case report and literature review.
Experimental and therapeutic medicineOrthodontic Appliance-Related Mucosal Ulcerations in Newborns and Infants With Craniofacial Disorders.
Clinical and experimental dental researchParental knowledge and access barriers in the management of cleft lip and/or palate: A cross-sectional study from Saudi Arabia.
MedicineFood Security Impacts Health of Children With Orofacial Clefts: An 8-Year Review of the Global Burden of Disease Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCleft Summit 2023: How NGOs can Promote Development of Sustainable Interdisciplinary Cleft Care.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationVisualizing the Timeline of Care: Development of a Graphical Approach to Better Understanding Complex, Longitudinal Surgical Care of Cleft Lip/Palate.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationComparative analysis of soft tissue response after orthognathic surgery in patients with and without cleft using 3D imaging: A preliminary study.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryBilateral orofacial clefts are associated with increased risk of psychiatric morbidity relative to unilateral clefts.
Journal of plastic, reconstructive & aesthetic surgery : JPRASThe unfinished journey: A narrative review of inequities in secondary cleft lip and palate care in low- and middle-income countries.
Tropical doctorStructural birth defects and exposure to oil and gas wells during pregnancy.
Pediatric researchComparison of the nasal complex in individuals with and without cleft lip and palate using cone-beam computed tomography.
Imaging science in dentistryThe role of Rho GTPases in facial morphogenesis.
Developmental dynamics : an official publication of the American Association of AnatomistsPleiotropic genes linking congenital hypogonadotropic hypogonadism and cleft lip/palate: evidence from a genomic CHH cohort study.
European journal of human genetics : EJHGBuccinator myomucosal flap with rotational flap in repair of midline and distal palatal Fistulas: A comparative study of 30 cases with speech outcome evaluation.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryDescriptive Exploration of Features Among Infants With Prenatal Fentanyl Exposure in a Multisite Cohort of Maternal-Infant Dyads Affected by Opioid Use Disorder.
Journal of addiction medicine'This is the Test of Our Faith': An Exploratory Study of the Religio-spiritual and Cultural Construction of Cleft Lip and Palate Among Muslim Parents in Punjab, Pakistan.
Journal of religion and healthCraniofacial features associated with Hutchinson - Gilford progeria syndrome - A case report.
StomatologijaEtiological Factors of Orofacial Clefts in a Hospital-Based Population: A Descriptive Analytical Study.
CureusLong-Term Velopharyngeal Insufficiency-Related Quality of Life in Cleft Palate Patients: Speech and Surgical Factors.
International dental journalPrevalence and risk factors of cleft lip and/or palate in Ethiopia: A systematic review and meta-analysis.
Journal of stomatology, oral and maxillofacial surgeryThe association between paternal race and ethnicity and a spectrum of birth defects in a national case-control study.
Annals of epidemiologyOut of the Laboratory and Into the Clinic: Out-of-Domain Validation of Machine Learning Models for Velopharyngeal Dysfunction Detection.
Annals of plastic surgeryExamining Sociodemographic Disparities in Diagnostic Delays and Surgical Management of Non-Syndromic Craniosynostosis: A 10-Year Review.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationSubcutaneous Emphysema Following Tracheocutaneous Fistula Closure in a Pediatric Patient: A Case Report.
CureusLaterality and Completeness Patterns of Nonsyndromic Clefts in a Multiethnic Cohort.
medRxiv : the preprint server for health sciencesrs2033806 at PAX3 Gene Associated with Non-syndromic Oral Cleft among the Chinese Population.
The Chinese journal of dental researchThe Suggestive Association Between the NOG rs227731 Polymorphism and Non-Syndromic Cleft Lip With or Without Palate Subtypes in a Japanese Cohort.
Congenital anomaliesComparison of palatal lengthening and perioperative outcomes of Furlow's Z-plasty versus von Langenbeck's palatoplasty in children with complete, non-syndromic cleft palate: a randomized controlled trial in India.
Archives of craniofacial surgeryPrenatally Diagnosed 7q11.23 Copy Number Variations: A Retrospective Case Series.
Molecular genetics & genomic medicineSurgical management and outcomes of recurrent palatal fistulae: Insights from CLAPP's institutional experience.
Journal of plastic, reconstructive & aesthetic surgery : JPRAS[Early diagnosis of congenital craniofacial differences: a systematic review of current evidence].
Revista cientifica odontologica (Universidad Cientifica del Sur)Barriers and delays in access to cleft surgery among children with cleft deformities in Rwanda: a qualitative study.
BMJ openBuccal Sulcus Myomucosal Flap-an Approach for the Closure of Anterior Palatal Fistulae: A Retrospective Cohort Analysis of 132 Patients.
Annals of plastic surgeryAssociated congenital malformations, syndromes, and medical conditions in patients with orofacial clefts: a 10-year hospital-based study in Thailand.
Frontiers in oral healthA history of the shared airway: anaesthesia in ENT.
The Journal of laryngology and otology3D-Printed Models in Oral Surgery Simulation Training: A Scoping Review.
Journal of dental educationDo Pharyngeal Flaps Have a Greater Risk of Obstructive Sleep Apnea Than Other Speech Procedures? A Systematic Review and Meta-Analysis.
Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial SurgeonsDental anomalies in subjects with non-syndromic cleft lip and palate.
StomatologijaDetectable AI-Generated Text in the Journal of Craniofacial Surgery : A Comparison of 2014 and 2024 Publications.
The Journal of craniofacial surgery[Research progress on regulatory variants in non-coding regions in non-syndromic cleft lip with or without cleft palate].
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatologyDifferent Characteristics of Maxillary Development and Bone Defect: An Observation from Unilateral Cleft Lip Patients With Complete and Incomplete Cleft Palate.
The Journal of craniofacial surgeryPredictors of Vocabulary and Morphosyntax Ability in 2-Year-Old Children with Repaired Cleft Palate.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationAdvancing Prediction of Secondary Speech Surgery After Palatoplasty.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationThree-Dimensional Evaluation of Secondary Alveolar Bone Grafting in Patients With Bilateral Cleft Lip and/or Palate: A 2-3-Year Post-Operative Follow-Up.
Orthodontics & craniofacial researchExpanding the Genetic Spectrum of Non-Syndromic Cleft Lip and Palate Through Whole-Exome Sequencing.
International journal of molecular sciencesExploring Current Trends, Challenges and Future Directions of Intraoral Digital Impression in the Management of Patients with Cleft Lip and/or Palate: A Narrative Literature Review.
Children (Basel, Switzerland)Successful Premaxillary Reconstruction and Oronasal Fistula Closure in a Patient With VATER Syndrome With Bilateral Cleft and Missing Premaxilla.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationEffect of Language Interpreter Modalities on Patient Satisfaction and Clinical Workflow: A Pilot Study in a Multidisciplinary Pediatric Craniofacial Clinic.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationSurgical Outcomes of Submucous Cleft Palate Using Intravelar Veloplasty with a Buccinator Musculomucosal Flap: A Case Series.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationAssessment of facial asymmetry in patients with orofacial cleft based on the biometric proposal of the average male face.
Clinical oral investigationsNavigating Airway Obstacles: Effective Anesthesia Strategies for Severe Robinson Sequence in a 3 year old.
The Medical journal of MalaysiaHaematological trends and associated congenital anomalies in children with cleft lip and palate.
The Medical journal of MalaysiaSpeech outcomes following Le Fort I maxillary advancement in cleft lip and palate patients: A retrospective evaluation using the Borel-Maisonny classification.
Journal of stomatology, oral and maxillofacial surgerySustainable Health Programs: Challenges and Pathways to Success.
Annals of plastic surgeryOrthodontic Care Delivery Across ACPA Teams in the US.
Annals of plastic surgeryOrthodontic treatment planning in cleft and craniofacial patients with clear aligners: burden of care and informed consent.
The Journal of forensic odonto-stomatologyNeuroendocrine Axis Investigation in Patients with Arhinia, Hemiarhinia and Associated Malformations.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationAgreement Between Hypernasality Ratings and Nasalance Scores in Spanish-English Bilingual Patients with Cleft Palate.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationOtitis Media With Effusion in Patients With Cleft Palate.
Clinical pediatrics[Parent-of-origin effects of FGF/FGFR signaling pathway candidate gene polymorphisms on the risk of non-syndromic cleft lip with or without cleft palate].
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhiAudiological Characterization in Children With Isolated Robin Sequence During the First Year of Life: A Retrospective Study.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationBuccal Fat Pad Adjunctive Flap During Primary Cleft Palate Repair: Effects on Maxillary Dimensions and Molar Eruption.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial Association"Barriers to Care Associated with Pediatric Orofacial Clefts Global Disease Burden".
Plastic and reconstructive surgeryComparative Outcomes of Conventional Bardach Two-Flap Palatoplasty Versus Modified Alveolar Ridge/Crevicular Incision Technique in Isolated Cleft Palate Repair: A Prospective Observational Study.
CureusSilver-Russell syndrome secondary to rare (epi)genotypes exhibits phenotypic heterogeneity challenging clinical diagnosis.
Clinical epigeneticsSurgical treatment of 89 patients with craniofacial microsomia in a craniofacial national reference centre in Finland.
Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial SurgeryWhich Prediction Works Best? A 3-Dimensional Evaluation of Mixed Dentition Analysis in Cleft Lip and Palate.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationCorrigendum to "Geometric Morphometric Study of ear Shape in Four Chinese Ethnic Minority Populations".
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationMorphometric Evaluation of the Pterygomaxillary Suture in Patients with Unilateral and Bilateral Cleft Lip and Palate Using Cone-Beam Computed Tomography.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationHong Kong and Macao Speech-Language Pathologists' Experiences in the Clinical Practice of Cleft Palate Speech/Velopharyngeal Dysfunction.
The Cleft palate-craniofacial journal : official publication of the American Cleft Palate-Craniofacial AssociationAssociações
Organizações que acompanham esta doença — pra ter apoio e orientação
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Referências e fontes
Bases de dados externas citadas neste artigo
Publicações científicas
Artigos indexados no PubMed ligados a esta doença no grafo RarasNet — título, periódico e PMID direto da fonte, sem intermediação de IA.
- Anaesthetic management of a paediatric patient with Goldenhar syndrome for oral rehabilitation and palatoplasty.
- Midline congenital upper lip sinus: a rare clinical case with analytical review of diagnostic and therapy strategies.
- Acetylation-triggered degradation of MSX1 impairs palatal development.
- Toward Understanding the Role of miRNAs in Cleft Palate Only: Observations from Patient Tissues and In Vitro Assays.
- Association of prenatal exposure to polychlorinated biphenyls with cleft lip and/or palate risk in offspring: A case-control study.
- An RCT Evaluating the Efficacy of Using Platelet-Rich Fibrin (PRF) with Conventional Technique of Cleft Palate Repair.
- Development and Validation of a Parent-Reported Clinical Screening Instrument for Team Care of Young Children with a Cleft: The CleftChild-8.
- From Anatomy to Application: A Developmental Framework for Suprazygomatic Maxillary Nerve Block in Pediatric Palatoplasty.
- Associations Between Alcohol Dehydrogenase Mutations and Cleft Lip/Palate: A Scoping Review.
- Congenital hypothyroidism with preserved fifth digits in SMARCA4-related Coffin-Siris syndrome: a case report.
Bases de dados e fontes oficiais
Identificadores e referências canônicas usadas para montar este verbete.
- ORPHA:2014(Orphanet)
- MONDO:0016064(MONDO)
- Variantes catalogadas(ClinVar)
- Busca completa no PubMed(PubMed)
- Q27677677(Wikidata)
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar
