Pular para o conteúdo
Malária
ORPHA:673CID-10 · B54CID-11 · 1F40ENDÊMICA NO BRASIL
Esta condição está no Orphanet, mas não é rara no Brasil. Endêmica Amazônia BR — ~140k casos/ano; notificação imediata. Fonte: PRC4-2017.
Esta doença tem causa genética. Recomendamos procurar um médico geneticista para diagnóstico, exames genéticos e aconselhamento familiar.
Sangue / imuneInício todas idadesHerança Unknown
Também conhecida comoPaludismoImpaludismoFebre palustreFebre intermitente

A malária é uma doença grave e por vezes fatal causada por um parasita que normalmente infecta um certo tipo de mosquito que se alimenta de seres humanos. A infecção com parasitas da malária pode resultar numa grande variedade de sintomas, desde sintomas ausentes ou muito ligeiros até doença grave e até morte. As pessoas que contraem malária geralmente ficam muito doentes, com febre alta, calafrios e sintomas semelhantes aos da gripe. Em geral, a malária é uma doença curável se for diagnosticada e tratada pronta e correctamente. O tratamento depende de muitos factores, incluindo a gravidade da doença, a espécie de parasita da malária que causa a infecção e a parte do mundo onde a infecção foi adquirida.

Última verificação: Fonte: sem afirmação sobre o SUS a verificarEm construçãohistóricoSugerir correção
Mantido por Agente Raras·Colaborar como especialista →

Introdução

O que você precisa saber de cara

💬
EM LINGUAGEM SIMPLES

A malária é uma doença infecciosa transmitida pela picada de mosquitos infectados por parasitas. O quadro costuma provocar febre alta, calafrios intensos, dores de cabeça e cansaço com aspecto de gripe forte. Em grande parte dos casos, a infecção tem cura se for diagnosticada e tratada de forma correta e sem atrasos. Embora a doença não figure na lista de PCDTs específicos de doenças raras do Ministério da Saúde, o atendimento ocorre pela rede pública de saúde.

📋
Informacoes curadas por IA — podem conter imprecisoes

A malária é uma doença grave e por vezes fatal causada por um parasita que normalmente infecta um certo tipo de mosquito que se alimenta de seres humanos. A infecção com parasitas da malária pode resultar numa grande variedade de sintomas, desde sintomas ausentes ou muito ligeiros até doença grave e até morte. As pessoas que contraem malária geralmente ficam muito doentes, com febre alta, calafrios e sintomas semelhantes aos da gripe. Em geral, a malária é uma doença curável se for diagnosticada e tratada pronta e correctamente. O tratamento depende de muitos factores, incluindo a gravidade da doença, a espécie de parasita da malária que causa a infecção e a parte do mundo onde a infecção foi adquirida.

Pesquisas ativas
85 ensaios
1132 total registrados no ClinicalTrials.gov
Publicações científicas
104.989 artigos
Último publicado: 2026 Apr 17
Medicamentos
3 com registro
COARTEM, LQFEX - MEFLOQUINA, doxycycline (DOXYCYCLINE)

Tem tratamento?

✓ 3 medicamentos específicos desta doença (registro ANVISA, FDA ou SUS/CEAF)
Ver detalhes, fases e interações →
COARTEMLQFEX - MEFLOQUINADOXYCYCLINE (DOXYCYCLINE)

Escala de raridade

CLASSIFICAÇÃO ORPHANET · BRASIL 2024
1-9 / 100 000
Ultra-rara
<1/50k
Muito rara
1/20k
Rara
1/10k
Pouco freq.
1/5k
Incomum
1/2k
Prevalência
3.0
Europe
Início
All ages
🏥
SUS: Cobertura mínimaScore: 0%
CID-10: B54
Você se identifica com essa condição?
O Raras está aqui pra te apoiar — com ou sem diagnóstico

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Entender a doença

Do básico ao detalhe, leia no seu ritmo

Preparando trilha educativa...

Sinais e sintomas

O que aparece no corpo e com que frequência cada sintoma acontece

Partes do corpo afetadas

🩸
Sangue
3 sintomas
👁️
Olhos
1 sintomas
🫁
Pulmão
1 sintomas
🧠
Neurológico
1 sintomas
🫃
Digestivo
1 sintomas
🫘
Rins
1 sintomas

+ 7 sintomas em outras categorias

Características mais comuns

90%prev.
Febre
Muito frequente (99-80%)
90%prev.
Anormalidade morfológica do sistema nervoso central
Muito frequente (99-80%)
90%prev.
Náusea e vômito
Muito frequente (99-80%)
90%prev.
Lesão renal aguda
Muito frequente (99-80%)
90%prev.
Concentração elevada de proteína C-reativa circulante
Muito frequente (99-80%)
90%prev.
Cefaleia
Muito frequente (99-80%)
16sintomas
Muito frequente (7)
Frequente (8)
Ocasional (1)

Os sintomas variam de pessoa para pessoa. Abaixo estão as 16 características clínicas mais associadas, ordenadas por frequência.

FebreFever
Muito frequente (99-80%)90%
Anormalidade morfológica do sistema nervoso centralMorphological central nervous system abnormality
Muito frequente (99-80%)90%
Náusea e vômitoNausea and vomiting
Muito frequente (99-80%)90%
Lesão renal agudaAcute kidney injury
Muito frequente (99-80%)90%
Concentração elevada de proteína C-reativa circulanteElevated circulating C-reactive protein concentration
Muito frequente (99-80%)90%

Linha do tempo da pesquisa

Publicações por ano — veja quando o interesse científico cresceu
Anos de pesquisa1desde 2026
Total histórico104.989PubMed
Últimos 10 anos200publicações
Pico2026196 papers
Linha do tempo
2026Hoje · 2026🧪 1982Primeiro ensaio clínico
Publicações por ano (últimos 10 anos)

Encontrou um erro ou informação desatualizada? Sugira uma correção →

Genética e causas

O que está alterado no DNA e como passa nas famílias

🧬

Nenhum gene associado encontrado

Os dados genéticos desta condição ainda estão sendo catalogados.

Diagnóstico

Os sinais que médicos procuram e os exames que confirmam

Carregando...

Tratamento e manejo

Remédios, cuidados de apoio e o que precisa acompanhar

Pipeline de tratamentos
Pipeline regulatório — de medicamentos já aprovados a drogas em pesquisa exploratória.
✓Aprovado11
3Fase 314
2Fase 210
1Fase 117
·Pré-clínico48
Medicamentos catalogadosEnsaios clínicos· 0 medicamentos · 100 ensaios
Carregando informações de tratamento...

Onde tratar no SUS

Hospitais de referência no Brasil e o protocolo oficial do SUS (PCDT)

🇧🇷 Atendimento SUS — Malária

🗺️

Selecione um estado ou use sua localização para ver resultados.

Dados de DATASUS/CNES, SBGM, ABNeuro e Ministério da Saúde. Sempre confirme a disponibilidade diretamente com o estabelecimento.

Pesquisa ativa

Ensaios clínicos abertos e novidades científicas recentes

Onde estão os ensaios

Com ensaio aberto em 37 países. O ponto verde marca onde há vaga agora.

🟢 Recrutando agora

44 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

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Publicações mais relevantes

Timeline de publicações
43.654 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 43.654

#1

Dengue transmission dynamics in an urban setting in western India.

PLoS neglected tropical diseases2026 Mar 23

Este estudo sobre a dengue em Goa, Índia, destaca um aumento acentuado de casos na última década, com projeções de crescimento contínuo, especialmente no norte da região. O sorotipo DENV-2 é o mais prevalente, e a transmissão está fortemente ligada a chuvas intensas com um atraso de 2-3 meses. Para pacientes, isso significa um risco elevado de dengue, especialmente em áreas como Candolim, Porvorim e Panaji, e a importância de precauções durante e após a estação chuvosa. Para médicos, o estudo ressalta a necessidade de vigilância focada em DENV-2, controle vetorial preventivo antes das monções e uso de alertas climáticos para antecipar e gerenciar surtos, priorizando as regiões de alto risco.

🇧🇷 traduzido
#2

Phase separation of heterochromatin protein 1 regulates virulence gene expression in Plasmodium falciparum.

Cell reports2026 Mar 22

O parasita da malária *Plasmodium falciparum* evade o sistema imunitário humano pela variação antigénica, um processo crucial onde apenas um gene *var* é expresso por vez para manter a sua virulência e persistência. Este estudo revela que a proteína PfHP1 silencia a maioria dos genes *var* através de um mecanismo de "separação de fase" que organiza o DNA. A interrupção desta separação leva à ativação de múltiplos genes *var*, sugerindo um novo alvo terapêutico para tornar o parasita mais vulnerável ou interferir na sua capacidade de causar doença.

🇧🇷 traduzido
#3

Temporal trends in Plasmodium vivax diversity in eastern Cambodia evidence declining transmission.

medRxiv : the preprint server for health sciences2026 Mar 04

A malária por *Plasmodium vivax* é um desafio devido às recaídas causadas por parasitas dormentes no fígado (hipnozoítos), embora o número de casos tenha diminuído no Camboja. Um estudo genético recente demonstrou uma queda significativa na diversidade do parasita e nas infecções múltiplas, indicando menor transmissão, o que coincide com o uso intensificado de primaquina (para cura radical). Esses achados fornecem evidências cruciais para médicos e pacientes de que a ampla aplicação da cura radical é fundamental para prevenir recaídas e conter eficazmente a transmissão da malária por *P. vivax*.

🇧🇷 traduzido
#4

Characterization of arbovirus infections in patients within Haiti by screening discarded malaria rapid diagnostic test cassettes.

PLoS neglected tropical diseases2026 Mar

Em meio à insegurança no Haiti que dificulta a vigilância de doenças, este estudo demonstrou que testes rápidos de malária descartados podem ser uma ferramenta eficaz para monitorar arbovírus circulantes. Eles identificaram exclusivamente um surto de Dengue tipo 3 em 2023, uma informação vital para médicos diagnosticarem e tratarem pacientes. Essa abordagem inovadora oferece uma maneira prática de identificar ameaças à saúde pública e orientar a resposta médica, mesmo em condições adversas.

🇧🇷 traduzido
#5

Malaria parasitemia and its association with liver function parameters, and lipid profile among malaria-infected adult patients in western Ethiopia: A comparative cross-sectional study.

PloS one2026

Este estudo mostra que pacientes adultos com malária em Assosa, Etiópia, apresentam alterações significativas na saúde. Eles têm níveis mais altos de enzimas hepáticas (AST, ALT) e bilirrubina, indicando disfunção do fígado, e níveis mais baixos de colesterol total, HDL e LDL. Para prevenir complicações da doença, é crucial que médicos avaliem rotineiramente a função hepática e o perfil lipídico em indivíduos infectados por malária.

🇧🇷 traduzido

Publicações recentes

Ver todas no PubMed

📚 EuropePMC64.783 artigos no totalmostrando 198

2026

Robust Bioconjugated Antigens Induce Immune Responses Preventing Malaria Infection and its Transmission.

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The research progress on the role of glucose-6-phosphate dehydrogenase in immune regulation.

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Identification of micro-level malaria hotspots and its Implications for achieving malaria elimination target in a remote district of India.

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[Diagnosis of lung cancer].

Deutsche medizinische Wochenschrift (1946)
2026

Dengue transmission dynamics in an urban setting in western India.

PLoS neglected tropical diseases
2026

Phase separation of heterochromatin protein 1 regulates virulence gene expression in Plasmodium falciparum.

Cell reports
2026

4-Aminoquinolines block heme iron reactivity and interfere with artemisinin action.

eLife
2026

Emerging insights into chemistry and therapeutic potentials of functionalized hexahydroquinolines.

Frontiers in chemistry
2026

Temporal trends in Plasmodium vivax diversity in eastern Cambodia evidence declining transmission.

medRxiv : the preprint server for health sciences
2026

Daily pattern of oviposition and fecundity in Anopheles pseudopunctipennis Theobald, the main vector of malaria in Mexico.

Malaria journal
2026

A systematic review of entomological outcomes and sampling approaches used in the evaluation of cluster randomised controlled trials for malaria vector control products.

Malaria journal
2026

Transfusion-transmitted infections among blood donors in Saudi Arabia: demographic and malaria risk differences by donation purpose.

Hematology (Amsterdam, Netherlands)
2026

Unique aspects of the acute kidney injury associated with infections in the tropics: presentation, challenges and opportunities.

Kidney international
2026

Molecular detection and epidemiological characterization of dengue and malaria coinfection in the Guiriko region, Burkina Faso.

Acta tropica
2026

High-throughput phenotypic screening of Medicines for Malaria Venture's Hit Generation Library 1 identifies new nematocidal chemotypes.

International journal for parasitology. Drugs and drug resistance
2026

Large-scale land investment, disease prevalence and infant mortality in Cambodia.

Health &amp; place
2026

Post-Artemisinin anti-malarial discovery from nature: unaltered natural products, lead optimisation, and advanced techniques in the discovery.

Natural product research
2026

[Data for cultural history of malaria in Hungary].

Orvosi hetilap
2026

Assessing the potential impact of the RTS,S/ASO1 vaccine on malaria burden in Benin: a mathematical modelling approach.

Malaria journal
2026

Prevalence of placental Plasmodium falciparum malaria and associated factors among pregnant women in health facilities in Eastern Uganda.

Malaria journal
2026

Flow cytometry-based evaluation of hepatic infection by non-fluorescent Plasmodium parasites.

International journal for parasitology
2026

Global burden shift from infectious to non-communicable neurological disorders in adolescents and young adults (10-24 years): findings from the global burden of disease study 1990-2021.

International journal of clinical pharmacy
2026

Host-directed therapeutic strategies against apicomplexan parasites: targeting purinergic P2 receptors.

Purinergic signalling
2026

Early childhood intervention for children at risk of developmental disabilities and their caregivers in Rwanda: study protocol for the PDC/Baby Ubuntu cluster randomised trial.

Trials
2026

Progression from uncomplicated to severe malaria among children in settings receiving different combinations of malaria control interventions in sub-Saharan Africa: a systematic review and meta-analysis.

Tropical medicine and health
2026

A simple bedside technique for managing a non-deflating Foley catheter balloon in a resource-limited setting - a case report.

International journal of emergency medicine
2026

Frequent Plasmodium ovale recurrence in coastal Tanzania.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2026

Gut check: converging evidence links microbiome to malaria risk.

Trends in parasitology
2026

Antiplasmodial and cytotoxic metabolites from the aerial parts of Vernonia glabra (Asteraceae).

Phytochemistry
2026

Women's perspectives on health service integration for multi-morbidity in pregnancy, childbirth, and postpartum in a high-burden setting.

Med (New York, N.Y.)
2026

Characterization of arbovirus infections in patients within Haiti by screening discarded malaria rapid diagnostic test cassettes.

PLoS neglected tropical diseases
2026

Malaria parasitemia and its association with liver function parameters, and lipid profile among malaria-infected adult patients in western Ethiopia: A comparative cross-sectional study.

PloS one
2026

Intelligent in-silico prioritization of antimalarial peptide candidates under explicit physicochemical windows via de novo CTCM-Neo generation and conformal-gated calibrated classification.

Frontiers in cellular and infection microbiology
2026

Prevalence, Morphological Types, and Associated Factors of Neonatal Anemia at a Rural Referral Hospital, Uganda.

Journal of blood medicine
2026

Mechanisms of carbamate resistance in the malaria vector: Anopheles gambiae.

Parasite epidemiology and control
2026

Integrative homology, AI-based modelling of PfSET3 and virtual screening of microbial-derived inhibitors as potential anti-malarial agents.

In silico pharmacology
2026

A diffusion model for mosquito control trials with spillover: application to calculations of power, sample size, and bias.

Trials
2026

Exploring the protective effects of thalassemia against malaria in Africa: a systematic review.

Systematic reviews
2026

Population pharmacokinetics of fosmidomycin and clindamycin in combination with artesunate for uncomplicated Plasmodium falciparum malaria in Gabonese children and adults.

Malaria journal
2026

Evaluation of malaria rapid diagnostic test kit performance in a high-transmission setting: a facility-based cross-sectional study in rural Ghana.

Malaria journal
2026

Evaluation of NxTek™ Eliminate Malaria-PF test and biocredit rapid diagnostic tests for detecting Plasmodium species in Southern Ethiopia.

BMC infectious diseases
2026

Systematic review of climate change interventions for improving child health.

BMJ paediatrics open
2026

Spatial distribution of HIV prevalence and associated factors in Guinea: retrospective cross-sectional study using Demographic and Health Surveys (DHS) data from 2012 and 2018.

BMJ open
2026

Structure-based design of new pyrazole inhibitors targeting Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH).

European journal of medicinal chemistry
2026

When yellow fever silenced the forest: Ecological collapse and reduced malaria transmission in the Rio de Janeiro Atlantic Forest, Brazil.

One health (Amsterdam, Netherlands)
2026

Prevalence and associated risk factors of malaria among febrile patients at Kidist Hana Health Center Fogera District, Amhara Regional State, Northwest Ethiopia.

Parasite epidemiology and control
2026

Spatio-temporal heterogeneity of urban malaria in Libreville, Gabon (2012-2023): neighborhood-level hotspot analysis for micro-stratified control.

Malaria journal
2026

Cerebral malaria caused by Plasmodium vivax in an afrodescendant adult in Colombia: case report.

Malaria journal
2026

Spatial distribution of urogenital schistosomiasis in school-aged children in Togo: an oversampling survey in three districts in 2022.

Parasites &amp; vectors
2026

Field and laboratory evaluation of Abbott-Bioline™ Malaria Ag Pf/Pv RDT performance in a high-transmission setting: contrasting results with a low-endemic area.

Malaria journal
2026

The genomics of insecticide resistance in Anopheles funestus: insights from a large bed-net trial.

BMC genomics
2026

Advancing global malaria control: therapeutic strategies, drug discovery, and formulation innovations.

Infection
2026

Botanical mystery solved: how plants make a crucial malaria drug.

Nature
2026

Mechanistic insights into coordinated var transcriptional switching in malaria parasites.

The EMBO journal
2026

Hydroxamate-based inhibitors reveal structural determinants of selectivity for Plasmodium falciparum aminopeptidase P.

The Journal of biological chemistry
2026

Global burden of adverse effects of medical treatment from 1990 to 2021: a Global Burden of Disease Study 2021.

The Korean journal of internal medicine
2026

Interrater Reliability of Electroencephalogram Interpretations in Febrile Comatose African Children: Implications for Automated Interpretation Algorithm Creation.

The American journal of tropical medicine and hygiene
2026

[Expansion of the use of technologies to reduce cases of malaria due to Plasmodium vivax in the Brazilian Amazon: a budget impact analysis].

Cadernos de saude publica
2026

Coinfection with malaria alters the fecundity and within-host persistence of an intestinal nematode.

PLoS neglected tropical diseases
2026

Microfluidic platform for automatic quantification of malaria parasite invasion under physiological flow conditions.

Lab on a chip
2026

Inhibition of prolyl-tRNA synthetase and efflux pumps as a dual-targeting strategy against multidrug-resistant bacteria.

Journal of enzyme inhibition and medicinal chemistry
2026

Targeting Iron Homeostasis Curtails Mosquito Fertility and Plasmodium Transmission Potential.

ACS infectious diseases
2026

Strengthening operational research to complement Global Fund grants for HIV, TB and malaria in Sierra Leone.

Public health action
2026

Enhancing TB case detection: a case study of Kenya's Global Fund-supported public-private mix.

Public health action
2026

Viral load testing coverage and suppression rate among children and adolescents on ART in Sierra Leone.

Public health action
2026

Minimum inoculum of resistance assay for evaluating for anti-toxoplasmosis compounds that target phenyl alanine tRNA synthetase.

bioRxiv : the preprint server for biology
2026

Host biological sex directs immune control of the Plasmodium parasite liver stage in mice.

Frontiers in immunology
2026

B and T cell responses to pre-erythrocytic R21/Matrix-M and blood-stage RH5.1/Matrix-M malaria vaccines in endemic settings.

Frontiers in immunology
2026

Targeted Genomic Surveillance Unveils Genetic Variations Linked to Regional Malaria Drug Resistance Dynamics in India.

Open forum infectious diseases
2026

Predicting risk of Plasmodium vivax microscopy-detected episodes using serological markers in patients with Plasmodium falciparum malaria: a multi-country diagnostic performance evaluation.

The Journal of infectious diseases
2026

Polypharmacology in malaria treatment: single drugs, multiple mechanisms, greater impact.

Trends in parasitology
2026

Single-shot dual-modality quantitative phase and polarization microscopy.

Optics express
2026

Detection of supergroup B Wolbachia strains and their co-infection with Plasmodium falciparum in wild Anopheles funestus in southeastern Tanzania: implications for malaria control.

Parasites &amp; vectors
2026

Delay in malaria care-seeking for children under five in Africa: a systematic review.

Malaria journal
2026

Geographical Heterogeneity in Antimalarial Resistance Markers by Genomic Surveillance in Angola, 2023.

The American journal of tropical medicine and hygiene
2026

Emerging Artemisinin Partial Resistance in Southern Africa.

The American journal of tropical medicine and hygiene
2026

Assessing the impact of climate and control interventions on spatio-temporal malaria dynamics using a stochastic metapopulation model.

PLoS computational biology
2026

A bibliometric analysis of the Web of Science database elucidates recent trends in research on Culicidae.

Journal of medical entomology
2026

LL-37 selectively targets Plasmodium-infected erythrocytes and exhibits antimalarial activity.

PLoS pathogens
2026

Prevalence and associations of trachoma before interventions in six departments of the Colombian Amazon and Orinoquía.

PloS one
2026

Prevalence and risk factors of gross neurologic deficits in children after severe malaria: A systematic review and meta-analysis.

PloS one
2026

Functional assessment of prevalent kelch13 mutations reveals high-level artemisinin resistance potential in Bangladeshi Plasmodium falciparum.

mBio
2026

Molecular markers of antimalarial drug resistance in pfk13, pfmdr1, pfdhfr, and pfdhps genes of Plasmodium falciparum in a rural municipality in Cubal, Benguela Province, Angola (2022-2023).

Malaria journal
2026

Phenotypic and genotypic characterization of Plasmodium falciparum field isolates lacking pfhrp2 gene.

Malaria journal
2026

Further insights into the sialome switch of Amblyomma americanum adult females.

BMC genomics
2026

Unravelling complex interactions during Toxoplasma, Plasmodium, and Leishmania co-infections in French Guiana.

Scientific reports
2026

Causes of death from community settings: insights from verbal autopsy implementation in Tanzania.

BMJ global health
2026

Antimalarial compounds from Solanum nigrum: In vitro antiplasmodial evaluation and network pharmacology-based investigation of host immunomodulatory mechanisms.

Journal of ethnopharmacology
2026

Effects of insecticides and awareness on the dynamics of a delayed malaria model: A real-data calibration.

Journal of theoretical biology
2026

Suitable ecological niches of invasive malaria vector under present and projected climatic conditions in South of Iran.

PLoS neglected tropical diseases
2026

Peripheral Blood Erythrophagocytosis in Plasmodium falciparum Malaria.

American journal of hematology
2026

Targeting the Highly Invasive Malaria Vector Anopheles stephensi using Yeast RNAi Pesticides.

Research square
2026

Heme oxygenase-1 and malaria pathogenesis.

Frontiers in immunology
2026

Severe Plasmodium falciparum Malaria Complicated by Post-artemisinin Delayed Hemolysis in a Non-immune Pediatric Returning Traveler.

Cureus
2026

Point-of-care molecular diagnostics and drug-resistance mechanisms in neglected infectious diseases: current advances and future therapeutic opportunities.

Frontiers in cellular and infection microbiology
2026

Healthcare workers' beliefs, readiness, and acceptance of malaria vaccine in Southwest Nigeria: addressing misconceptions and uptake barriers.

Malaria journal
2026

Capsaicinoids prevent intestinal fluid secretion and motility by inhibiting chloride channels.

Journal of ethnopharmacology
2026

The Cost and Budget Impact of Malaria Vaccine Introduction in Uganda.

Value in health regional issues
2025

50-Year Bibliometrics of International Scientific Biomedical Publications on "Parasitic Diseases": MEDLINE (1970-2019).

La Tunisie medicale
2026

Suboptimal uptake of the malaria vaccine in Sudan: what's behind the blinds?

Malaria journal
2026

Malaria immunity in the infant: progress and pitfalls.

Current opinion in immunology
2026

Intravenous drug abuse - a concern for falciparum malaria along with HIV.

Journal of vector borne diseases
2026

Cardiospermum halicacabum Extract Attenuates UVB-Induced Photoaging in Human Skin Fibroblasts via Inhibition of the PI3K/Akt/mTOR Signaling Pathway.

International journal of molecular sciences
2026

Profiling 26S Proteasome Activity of Plasmodium falciparum Monitored by a Live-Cell Assay.

International journal of molecular sciences
2026

A tiger is not always a satyr: role of male mating behaviour in interspecific mating interactions between Aedes aegypti and Aedes albopictus.

Parasites &amp; vectors
2026

Timing of the fourth dose of RTS,S/AS01 malaria vaccine in perennial settings: a modelling study.

Malaria journal
2026

Extreme weather events and malaria prevention in pregnancy: a mediation analysis of antenatal care and sulfadoxine-pyrimethamine use in two malaria-endemic counties of Kenya.

Malaria journal
2026

Ischemic stroke during dengue-Plasmodium vivax coinfection in a young woman: a case report.

Malaria journal
2026

CCND3 enhancer variant reduces malaria risk.

Nature genetics
2026

Illustrating neurological disabilities: temporal fictions in public health infographics.

Medical humanities
2026

Knockdown resistance in mosquito vectors: Molecular mechanisms, global spread, and future directions for sustainable vector control.

Molecular and biochemical parasitology
2026

The Plasmodium falciparum PPCS is a unique heteromeric complex with prokaryote-like activity and is a target of pantothenate analogs.

Science advances
2026

The Cutaneous leishmaniasis impact questionnaire: Translation, cross-cultural adaptation and validation in adults with Cutaneous leishmaniasis in Ethiopia.

PLoS neglected tropical diseases
2026

Improving malaria chemoprevention coverage in pregnancy: Surveying stakeholder preferences for new product profiles and community-delivery approaches across five African countries.

PLOS global public health
2026

Adapting lessons from the Indian subcontinent to accelerate elimination of visceral leishmaniasis as a public health problem in East Africa.

PLoS neglected tropical diseases
2026

Burden, risk factors, and clinical outcomes of pediatric malaria in Nigeria: A systematic review and meta-analysis protocol.

PloS one
2026

Morphological Differentiation Among Three Mitochondrial Lineages of Hydrobioides nassa Theobald, 1865 (Gastropoda: Bithyniidae) from Thailand.

Biology
2026

Structure-Based Screening of Deep-Sea Microbial Metabolites Against Plasmodium falciparum Dihydroorotate Dehydrogenase.

Biology
2026

Immunological surveillance using anti-gSG6-P1 IgG biomarker reveals spatio-temporal dynamics of Anopheles exposure and gaps in malaria risk assessment in the Greater Mekong Subregion.

Parasite (Paris, France)
2026

Malaria in Greece: From Ancient Scourge to Eradication.

Cureus
2025

Malaria and malnutrition in tribal areas of India: implications for paediatric health.

Frontiers in gastroenterology (Lausanne, Switzerland)
2026

Musings from a Vectosaur: Malaria in 2026.

MalariaWorld journal
2026

In- vitro assessment of the anti- malarial potential of Alpha Onocerin; cytotoxicity and hemolytic effect, multi-stage activity and molecular docking.

BMC pharmacology &amp; toxicology
2026

Co-creation of community-based innovations to improve access to malaria treatment in conflict-affected regions of Cameroon.

Malaria journal
2026

Resurgence of malaria in Ethiopia: a national landscape analysis of systemic and operational gaps.

Malaria journal
2026

Effect of external cephalic version in a resource-limited setting on the Thailand-Myanmar border: a retrospective cohort with propensity score analysis.

BMC pregnancy and childbirth
2026

Differential expression of mitochondria-associated genes in clinical samples of Plasmodium falciparum showing severe manifestations.

BMC genomics
2026

Genetic diversity of plasmodium vivax merozoite surface protein 3α and β field isolates.

Diagnostic microbiology and infectious disease
2026

Prevalence of Coinfection with Malaria and Intestinal Helminths among School-Aged Children in Nwoya District, Northern Uganda: A Cross-Sectional Study.

The American journal of tropical medicine and hygiene
2026

A Study on Prevalence of Malarial Retinopathy among Malaria Cases and to Determine Its Presence as a Marker of Severe Malaria: Observations from Eastern India.

The Journal of the Association of Physicians of India
2026

Clinical and Laboratory Profile of Patients with Tropical Coinfections Admitted at a Tertiary Care Center in North India.

The Journal of the Association of Physicians of India
2026

Emergence of artemisinin-based combination therapy resistance markers in Plasmodium falciparum from the Brazilian tri-border region of the Guiana Shield.

Antimicrobial agents and chemotherapy
2025

The risks of exclusive reliance on rapid diagnostic tests for malaria in Angola.

The Pan African medical journal
2026

Advancing Global Health Education: Preparing Emergency Medicine Trainees for Low-Resource Settings Through Simulation-Based Training.

MedEdPORTAL : the journal of teaching and learning resources
2026

A Standardized Culture Medium for Comparative Drug Efficacy Evaluation Across Plasmodium and Babesia Species.

Bio-protocol
2026

Inclusion of antimicrobial resistance in a pandemic agreement: why it matters and what comes next?

Health affairs scholar
2026

Functional language performance outcomes on paediatric cochlear implant patients in Malawi.

Cochlear implants international
2026

Safety of Matrix-M-adjuvanted COVID-19, seasonal influenza, combination influenza-COVID-19, and malaria vaccines: a review of the evidence.

Expert review of vaccines
2026

Factors influencing the utilisation of malaria preventive services during pregnancy in Ile Ife, Nigeria: a mixed method approach.

Malaria journal
2026

Incidence and trends of adverse drug reactions during seasonal malaria chemoprevention among children: evidence from Ghana's pharmacovigilance database, 2015-2023.

Malaria journal
2026

High rate of undiagnosed cases of fever among returning travelers from tropical areas tested for malaria: a single-center retrospective study.

Travel medicine and infectious disease
2026

Molecular and metabolic mechanisms of pyrethroid resistance in Anopheles gambiae complex (Diptera: Culicidae) in West Africa: a systematic review.

Journal of medical entomology
2026

Awareness, attitudes, and control measures regarding malaria and mosquitoes in the North Region of Cameroon.

Journal of medical entomology
2026

Host preference and resting behavior of Anopheles coluzzii (Diptera: Culicidae) on the island of São Tomé, West Africa.

Journal of medical entomology
2026

Newborn Screening Results for Sickle Cell Disease from the ASH Consortium on Newborn Screening in Africa (CONSA).

Blood advances
2026

Economic evaluation of anti-malarial drug policies across presidential regimes in Nigeria: A comparative analysis from 1999 to present.

PloS one
2026

Comprehensive immune profiling reveals IFN-γ signaling in T cells mediates parasite phagocytosis in a rodent malaria model.

mBio
2026

Identification of Potential Therapeutic Agents for Primary Amebic Meningoencephalitis Using Text Mining and Bioinformatics Analyses.

Analytical cellular pathology (Amsterdam)
2026

Transcriptomics of Plasmodium vivax rosetting.

Memorias do Instituto Oswaldo Cruz
2026

Evaluation of the insecticide custody chain and its relationship with malaria burden in the Brazilian Amazon: a process and exploratory impact assessment (2019-2023).

Memorias do Instituto Oswaldo Cruz
2026

Estimating malaria attributable fraction using quantitative PCR in a longitudinal cohort in Eastern Uganda.

medRxiv : the preprint server for health sciences
2026

Prioritisation and risk ranking of epidemic-prone diseases for emergency preparedness and response in Eastern Africa using a multi-criteria decision analysis framework, 2023.

Journal of public health in Africa
2026

High-resolution UAV dataset for identification of breeding sites for malaria and dengue vectors in rural and peri-urban Tanzania: An experimental approach with Gemma 3N E4B architecture.

Data in brief
2026

Diagnostic methods for protozoan diseases: a review focused on leishmaniasis, Chagas disease and malaria.

Frontiers in microbiology
2026

Provincial stratification and equity-weighted cost-effectiveness of malaria vaccines in Zambia under climate variability.

BMJ public health
2026

Metagenomic studies reveal diverse microbial community in the developmental stages of highly adaptable malarial vector Anopheles stephensi liston.

3 Biotech
2025

The Impact of Aging on Organ Systems in Sickle Cell Disease: a Comparative Review of Physiological Adaptation and Dysfunction.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
2026

Malaria Vector Surveillance in Indonesia: COX1 Phylogenetic Reveals Monophyletic Clades and Cryptic Diversity in Anopheles Mosquitoes.

Journal of vector borne diseases
2026

Plasmodium falciparum GTP-cyclohydrolase 1 (Pfgch1) Gene Copy Number Variation and Its Implications in antimalarial resistance from Northeast India.

Journal of vector borne diseases
2026

Inventory of the Anopheles fauna (Diptera: Culicidae) in the Eastern Rif region of Morocco.

Journal of vector borne diseases
2026

Evaluation of the impact of malaria and erythrocyte G6PD deficiency on anaemia outcomes among children in Jos Northcentral Nigeria.

BMC research notes
2026

Anopheles coluzzii from Sakassou, Central Côte d'Ivoire show aggravated resistance to pyrethroids and organophosphate but are fully susceptible to clothianidin.

Parasites &amp; vectors
2026

Integrative preclinical strategy for pharmacokinetic profiling and candidate selection of 3-hydroxypropanamidines: a promising antimalarial class.

Malaria journal
2026

Treatment outcome and associated factors of severe malaria among admitted children in the Gambella Region, Southwest Ethiopia: a retrospective study design.

Malaria journal
2026

Contrasting evolutionary trajectories of pyrimethamine resistance in human and zoonotic malaria parasites.

Malaria journal
2026

US new playbook for global health: balancing national interest and global responsibility.

BMJ global health
2026

Fifty shades of iron: Unorthodox mechanisms of iron acquisition and utilization in blood-stage Plasmodium parasites.

PLoS pathogens
2026

Post-infection symptoms in U.S. soldiers with malaria during the Second World War: major limitation to return to duty.

MSMR
2026

Women's right to science and health: 30 years on, progress and gaps remain.

International health
2026

Examining the effects of climate and environmental hazards on vector and water-borne diseases in Eastern Uganda.

Discover Environment
2026

Heterogeneous duplication and point mutation of ace-1 confer organophosphates and carbamates resistance to Anopheles sinensis field populations in Guizhou Province, China.

Infectious diseases of poverty
2026

Diagnostic challenges of histidine-rich protein 2-based rapid diagnostic tests due to pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria in Tanzania.

Infectious diseases of poverty
2026

Determination of the preliminary discriminating concentration of broflanilide against malaria vector mosquito Anopheles gambiae by multi-centre susceptibility testing.

Malaria journal
2026

Utilization of malaria control interventions and associated factors among women of reproductive age in Lira City, Northern Uganda.

BMC public health
2026

Efficacy of dolutegravir-based therapy in achieving virological suppression in PLHIV in low- and middle-income countries: real-world evidence from a large clinical cohort in Cameroon.

BMC infectious diseases
2026

Country-specific estimates of misclassification rates of computer-coded verbal autopsy algorithms.

BMJ global health
2026

Comparison of the efficacy of cell wall disruption methods for Saccharomyces cerevisiae INVSc1 cells expressing Toxoplasma gondii recombinant ROP6 protein.

Protein expression and purification
2026

SPICE-GRADE: Simultaneous Processing of Indirect Causal Evidence in Complex Pathways Using GRADE -An Exploratory Case Study.

Journal of clinical epidemiology
2026

Lagged effect of temperature and rainfall on malaria incidence in Colombia (2013-2023): An approach with Bayesian spatiotemporal adjustment.

PLOS global public health
2026

Electronic Health Record-Linked Biobank Expansion Reveals Global Health Inequities.

Annual review of biomedical data science
2026

Baseline Procalcitonin and C-Reactive Protein Levels in Asymptomatic Individuals From West Africa With and Without P. falciparum Parasitemia.

Open forum infectious diseases
2026

A Systematic Review and Meta-Analysis of Diagnostic Test Accuracy for Human Toxoplasmosis: Performance, Populations, and Validation Gaps.

Medical devices (Auckland, N.Z.)
2026

A study protocol for a baseline community-based cross-sectional study to investigate malaria and dengue transmission dynamics in a development area of new capital city, Indonesia.

Wellcome open research
2026

Severe Malaria Due to Plasmodium vivax With Pulmonary Involvement: A Case Report.

Cureus
2026

Clashing in Murky Waters: On Amphibian Mosquito Suppression.

Ecology and evolution
2026

Meropenem and fosfomycin against K. pneumoniae: towards a combination breakpoint using a pharmacometric approach.

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
2026

Exploring the gut micriobiome in Anopheles mosquitoes: A promising new approach to malaria control.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
2026

Herbal product use in urban slum communities of Freetown, Sierra Leone: Consumption patterns, predictors, and ethnomedicinal applications.

Journal of ethnobiology and ethnomedicine
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Associações

Organizações que acompanham esta doença — pra ter apoio e orientação

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Doença com base genética

Um médico geneticista pode ajudar no diagnóstico de Malária e no aconselhamento genético da família.

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Conselhos e sociedades

Doenças relacionadas

Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico

Perguntas frequentes

O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu

Respostas geradas por IA a partir das fontes citadas

Sim, em geral a malária é considerada uma doença curável quando identificada e tratada prontamente. A resposta depende da gravidade inicial, da espécie do parasita e da precocidade das intervenções.

Referências

Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete

10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.

  1. ORPHA:673
    Orphanet
  2. GARD:6961
    GARD (NIH)
  3. Q12156
    Wikidata

Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.

Citar este verbete

Raras. (s.d.). Malária. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/malaria

Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.

Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Malária
Compêndio · Raras BR

Malária

ORPHA:673 · MONDO:0005136
Prevalência
1-9 / 100 000
Herança
Not applicable
CID-10
B54 · Malária não especificada
CID-11
Ensaios
85 ativos
Início
All ages
Prevalência
3.0 (Europe)
MedGen
UMLS
C0024530
Repurposing
25 candidatos
amodiaquine — histamine receptor agonist
artemether — antimalarial agent
artemisinin — DNA synthesis inhibitor
+17 outros
Wikidata
Wikipedia
Papers 10a

📋 Origem dos dados

Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.

Doença rara (ontologia)
fonte: Orphanet
Identificador unificado
fonte: MONDO
Indexação biomédica
fonte: MeSH (NLM)
Dado público estruturado
fonte: Wikidata
Medicamentos aprovados FDA
fonte: FDA OpenFDA
Rara