A malária é uma doença grave e por vezes fatal causada por um parasita que normalmente infecta um certo tipo de mosquito que se alimenta de seres humanos. A infecção com parasitas da malária pode resultar numa grande variedade de sintomas, desde sintomas ausentes ou muito ligeiros até doença grave e até morte. As pessoas que contraem malária geralmente ficam muito doentes, com febre alta, calafrios e sintomas semelhantes aos da gripe. Em geral, a malária é uma doença curável se for diagnosticada e tratada pronta e correctamente. O tratamento depende de muitos factores, incluindo a gravidade da doença, a espécie de parasita da malária que causa a infecção e a parte do mundo onde a infecção foi adquirida.
Introdução
O que você precisa saber de cara
A malária é uma doença infecciosa transmitida pela picada de mosquitos infectados por parasitas. O quadro costuma provocar febre alta, calafrios intensos, dores de cabeça e cansaço com aspecto de gripe forte. Em grande parte dos casos, a infecção tem cura se for diagnosticada e tratada de forma correta e sem atrasos. Embora a doença não figure na lista de PCDTs específicos de doenças raras do Ministério da Saúde, o atendimento ocorre pela rede pública de saúde.
A malária é uma doença grave e por vezes fatal causada por um parasita que normalmente infecta um certo tipo de mosquito que se alimenta de seres humanos. A infecção com parasitas da malária pode resultar numa grande variedade de sintomas, desde sintomas ausentes ou muito ligeiros até doença grave e até morte. As pessoas que contraem malária geralmente ficam muito doentes, com febre alta, calafrios e sintomas semelhantes aos da gripe. Em geral, a malária é uma doença curável se for diagnosticada e tratada pronta e correctamente. O tratamento depende de muitos factores, incluindo a gravidade da doença, a espécie de parasita da malária que causa a infecção e a parte do mundo onde a infecção foi adquirida.
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Sinais e sintomas
O que aparece no corpo e com que frequência cada sintoma acontece
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Características mais comuns
Os sintomas variam de pessoa para pessoa. Abaixo estão as 16 características clínicas mais associadas, ordenadas por frequência.
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Genética e causas
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Dengue transmission dynamics in an urban setting in western India.
Este estudo sobre a dengue em Goa, Índia, destaca um aumento acentuado de casos na última década, com projeções de crescimento contínuo, especialmente no norte da região. O sorotipo DENV-2 é o mais prevalente, e a transmissão está fortemente ligada a chuvas intensas com um atraso de 2-3 meses. Para pacientes, isso significa um risco elevado de dengue, especialmente em áreas como Candolim, Porvorim e Panaji, e a importância de precauções durante e após a estação chuvosa. Para médicos, o estudo ressalta a necessidade de vigilância focada em DENV-2, controle vetorial preventivo antes das monções e uso de alertas climáticos para antecipar e gerenciar surtos, priorizando as regiões de alto risco.
🇧🇷 traduzidoPhase separation of heterochromatin protein 1 regulates virulence gene expression in Plasmodium falciparum.
O parasita da malária *Plasmodium falciparum* evade o sistema imunitário humano pela variação antigénica, um processo crucial onde apenas um gene *var* é expresso por vez para manter a sua virulência e persistência. Este estudo revela que a proteína PfHP1 silencia a maioria dos genes *var* através de um mecanismo de "separação de fase" que organiza o DNA. A interrupção desta separação leva à ativação de múltiplos genes *var*, sugerindo um novo alvo terapêutico para tornar o parasita mais vulnerável ou interferir na sua capacidade de causar doença.
🇧🇷 traduzidoTemporal trends in Plasmodium vivax diversity in eastern Cambodia evidence declining transmission.
A malária por *Plasmodium vivax* é um desafio devido às recaídas causadas por parasitas dormentes no fígado (hipnozoítos), embora o número de casos tenha diminuído no Camboja. Um estudo genético recente demonstrou uma queda significativa na diversidade do parasita e nas infecções múltiplas, indicando menor transmissão, o que coincide com o uso intensificado de primaquina (para cura radical). Esses achados fornecem evidências cruciais para médicos e pacientes de que a ampla aplicação da cura radical é fundamental para prevenir recaídas e conter eficazmente a transmissão da malária por *P. vivax*.
🇧🇷 traduzidoCharacterization of arbovirus infections in patients within Haiti by screening discarded malaria rapid diagnostic test cassettes.
Em meio à insegurança no Haiti que dificulta a vigilância de doenças, este estudo demonstrou que testes rápidos de malária descartados podem ser uma ferramenta eficaz para monitorar arbovírus circulantes. Eles identificaram exclusivamente um surto de Dengue tipo 3 em 2023, uma informação vital para médicos diagnosticarem e tratarem pacientes. Essa abordagem inovadora oferece uma maneira prática de identificar ameaças à saúde pública e orientar a resposta médica, mesmo em condições adversas.
🇧🇷 traduzidoMalaria parasitemia and its association with liver function parameters, and lipid profile among malaria-infected adult patients in western Ethiopia: A comparative cross-sectional study.
Este estudo mostra que pacientes adultos com malária em Assosa, Etiópia, apresentam alterações significativas na saúde. Eles têm níveis mais altos de enzimas hepáticas (AST, ALT) e bilirrubina, indicando disfunção do fígado, e níveis mais baixos de colesterol total, HDL e LDL. Para prevenir complicações da doença, é crucial que médicos avaliem rotineiramente a função hepática e o perfil lipídico em indivíduos infectados por malária.
🇧🇷 traduzidoPublicações recentes
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Discover EnvironmentHeterogeneous duplication and point mutation of ace-1 confer organophosphates and carbamates resistance to Anopheles sinensis field populations in Guizhou Province, China.
Infectious diseases of povertyDiagnostic challenges of histidine-rich protein 2-based rapid diagnostic tests due to pfhrp2 and pfhrp3 gene deletions in asymptomatic malaria in Tanzania.
Infectious diseases of povertyDetermination of the preliminary discriminating concentration of broflanilide against malaria vector mosquito Anopheles gambiae by multi-centre susceptibility testing.
Malaria journalUtilization of malaria control interventions and associated factors among women of reproductive age in Lira City, Northern Uganda.
BMC public healthEfficacy of dolutegravir-based therapy in achieving virological suppression in PLHIV in low- and middle-income countries: real-world evidence from a large clinical cohort in Cameroon.
BMC infectious diseasesCountry-specific estimates of misclassification rates of computer-coded verbal autopsy algorithms.
BMJ global healthComparison of the efficacy of cell wall disruption methods for Saccharomyces cerevisiae INVSc1 cells expressing Toxoplasma gondii recombinant ROP6 protein.
Protein expression and purificationSPICE-GRADE: Simultaneous Processing of Indirect Causal Evidence in Complex Pathways Using GRADE -An Exploratory Case Study.
Journal of clinical epidemiologyLagged effect of temperature and rainfall on malaria incidence in Colombia (2013-2023): An approach with Bayesian spatiotemporal adjustment.
PLOS global public healthElectronic Health Record-Linked Biobank Expansion Reveals Global Health Inequities.
Annual review of biomedical data scienceBaseline Procalcitonin and C-Reactive Protein Levels in Asymptomatic Individuals From West Africa With and Without P. falciparum Parasitemia.
Open forum infectious diseasesA Systematic Review and Meta-Analysis of Diagnostic Test Accuracy for Human Toxoplasmosis: Performance, Populations, and Validation Gaps.
Medical devices (Auckland, N.Z.)A study protocol for a baseline community-based cross-sectional study to investigate malaria and dengue transmission dynamics in a development area of new capital city, Indonesia.
Wellcome open researchSevere Malaria Due to Plasmodium vivax With Pulmonary Involvement: A Case Report.
CureusClashing in Murky Waters: On Amphibian Mosquito Suppression.
Ecology and evolutionMeropenem and fosfomycin against K. pneumoniae: towards a combination breakpoint using a pharmacometric approach.
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious DiseasesExploring the gut micriobiome in Anopheles mosquitoes: A promising new approach to malaria control.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseasesHerbal product use in urban slum communities of Freetown, Sierra Leone: Consumption patterns, predictors, and ethnomedicinal applications.
Journal of ethnobiology and ethnomedicineAssociações
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Doença com base genética
Um médico geneticista pode ajudar no diagnóstico de Malária e no aconselhamento genético da família.
Doenças relacionadas
Doenças com sintomas parecidos — ajudam quem ainda está buscando diagnóstico
Perguntas frequentes
O que as famílias mais perguntam sobre esta doença — cada resposta com a fonte de onde saiu
Sim, em geral a malária é considerada uma doença curável quando identificada e tratada prontamente. A resposta depende da gravidade inicial, da espécie do parasita e da precocidade das intervenções.
Referências
Fontes citadas no texto, publicações do grafo e bases de dados usadas neste verbete
10 publicações do grafo RarasNet (PubMed) · 6 bases de dados. Títulos, periódicos e PMIDs vêm direto da fonte, sem intermediação de IA.
Dados compilados pelo RarasNet a partir de fontes abertas (Orphanet, OMIM, MONDO, PubMed/EuropePMC, ClinicalTrials.gov, DATASUS, PCDT/MS). Este conteúdo é informativo e não substitui avaliação médica.
Citar este verbete
Raras. (s.d.). Malária. Em Raras — Enciclopédia de Doenças Raras do Brasil. https://raras.org/doenca/malaria
Formato APA. Conteúdo sob CC BY 4.0 — reuso livre com atribuição.
Conteúdo mantido por Agente Raras · Médicos e pesquisadores podem colaborar

Malária
📋 Origem dos dados
Esta página agrega dados de fontes públicas e oficiais. Dados sobre cobertura no SUS (PCDT, CEAF) são verificados ativamente por agente proativo (ver badge no infobox). Demais dados têm atribuição de fonte + data da última sincronização — clique para abrir o original.
- Doença rara (ontologia)
- fonte: Orphanet
- Identificador unificado
- fonte: MONDO
- Codificação WHO/SUS
- fonte: WHO ICD-10 / DATASUS
- CID-11 (futuro)
- fonte: WHO ICD-11
- NIH/GARD
- fonte: GARD (NIH)
- Indexação biomédica
- fonte: MeSH (NLM)
- Dado público estruturado
- fonte: Wikidata
- Medicamentos aprovados FDA
- fonte: FDA OpenFDA
- Reposicionamento
- fonte: Drug Repurposing Hub
- Ensaios clínicos
- fonte: ClinicalTrials.gov