Leptospirose

Preventive Strategies for Early and Late Complications of Leptospirosis

NCT07127718

RECRUTANDO

Leptospirosis Registry - LeptoScope

NCT04288674

RECRUTANDO

Leptospirosis Care Bundle Study

NCT05425524

RECRUTANDO

Xpert® Tropical Fever Test on GeneXpert® Edge X System

NCT07520279

INSCRIÇÃO POR CONVITE

These Studies That Evaluated the Efficacy of Antibiotics for Leptospirosis Treatment.

NCT07865156

EM ANDAMENTO

Onde estão os ensaios

Com ensaio aberto em 5 países. O ponto verde marca onde há vaga agora.

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4 pesquisas recrutando participantes. Converse com seu médico sobre a possibilidade de participar.

NCT07127718 · Preventive Strategies for Early and Late Complications of Le…Recrutando

PHASE2Philippines

NCT04288674 · Leptospirosis Registry - LeptoScopeRecrutando

🇩🇪 Alemanha

NCT05425524 · Leptospirosis Care Bundle StudyRecrutando

NAThailand

NCT07520279 · Xpert® Tropical Fever Test on GeneXpert® Edge X SystemPor convite

🇺🇸 Estados Unidos

Outros ensaios clínicos

24 ensaios clínicos encontrados, 11 ativos.

Distribuição por fase

NCT07865156 · These Studies That Evaluated the Efficacy of Antibiotics for…Em breve

PHASE4

NCT07808775 · Assessment of the Risk of Zoonotic Infections in Prisons in …Em breve

French Guiana

NCT07611591 · Ex Vivo Study of Leukocyte Responses in the Blood of Patient…Em breve

NCT06945822 · Characterizing the Host Response to Leptospirosis for Better…Em breve

NA

NCT06859619 · Serological Measurement of Montpellier Professionals' Contac…Em breve

NA🇫🇷 França

NCT04211649 · Comparing Two Antibiotic Therapy Periods (3 Versus 7 Days) i…Em breve

PHASE4French Guiana · Guadeloupe · Martinique +2

NCT04034550 · Cohort of Hospitalized Patients Suspected of LeptospirosisAtivo

NA🇫🇷 França

NCT07821853 · N-Acetylcysteine in Patients With LeptospirosisConcluído

PHASE2Indonesia

NCT05436756 · Chronic Post-leptospirosis Manifestations in ReunionConcluído

NA🇫🇷 França · Reunion

NCT05300425 · Seroprevalence of Leptospirosis in Val Müstair, SwitzerlandConcluído

🇨🇭 Suíça

NCT05413720 · Study of the Innate Immune Response to the Acute Phase of Hu…Concluído

NAReunion

NCT03497572 · Seroprevalence Study to Evaluate the Persistence of Anti-lep…Concluído

🇫🇷 França

NCT03912506 · Severe Leptospirosis in Non-tropical AreasConcluído

🇫🇷 França

NCT01766830 · Rapid Diagnostic Tests and Clinical/Laboratory Predictors of…Concluído

NACambodia · Democratic Republic of the Congo · Nepal +1

NCT01080989 · The Sero-Prevalence and Genetic Study for the Infectious Dis…Concluído

NA🇹🇼 Taiwan

NCT04882046 · Study of the Incidence of Jarisch-Herxheimer Reaction in Lep…UNKNOWN

NANew Caledonia

NCT02898519 · Immune Response After Leptospirosis InfectionUNKNOWN

NCT02000635 · Study of Decreasing Kinetics of the Leptospiremia During Ant…UNKNOWN

Martinique

NCT01607047 · French West Indies Leptospirosis StudyUNKNOWN

🇫🇷 França

NCT00592566 · Desmopressin and Dexamethasone Adjunctive Treatment for Lept…Encerrado

PHASE2, PHASE3Thailand

Ver todos no ClinicalTrials.gov

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Publicações mais relevantes

Timeline de publicações

3.612 papers (10 anos)

Mostrando amostra de 200 publicações de um total de 3.612

#1

DMEM and EMEM as alternate growth media for pathogenic Leptospira.

PLoS neglected tropical diseases2026 Mar

Pathogenic Leptospira species can survive and thrive in a wide range of environments. Distinct environments expose the bacteria to different temperatures, osmolarities, and amounts and sources of nutrition. However, leptospires are mostly cultured in a laboratory setting under in vitro conditions that do not reflect natural environments. This constraint on laboratory cultures limits the applicability of in vitro studies to the understanding of even simple pathogenic processes. Here we report, investigate, and identify a medium and conditions that mimic the host environment during leptospirosis infection, expanding the available in vitro tools to evaluate leptospiral pathogenesis. We quantified genome-wide transcription of pathogenic Leptospira interrogans cultured in different in vitro media compositions and conditions-EMJH at 29 °C and DMEM, EMEM, and HAN at 37 °C and 5% CO2. Using EMJH as standard, we compared gene expression in these compositions to genome-wide transcription gathered in a host environment: whole blood (WB) of hamsters after infection with pathogenic leptospires. Leptospires cultured in DMEM and EMEM media shared 40% and 47% of all differentially expressed genes (DEGs) of leptospires present within WB (FDR < 0.01), while leptospires cultured in HAN media only shared 20% of DEGs with those from WB. Furthermore, gene and pathway expression of leptospires cultured on DMEM and EMEM media exhibited a better correlation with leptospires grown in WB, including promoting expression of a similar leptospiral lipid A profile to the one identified directly in host tissues. Taken together, these results indicate that commercial cell-culture media EMEM or DMEM are better surrogates for in vivo pathogenic studies than EMJH or HAN media in Leptospira. These alternative culture conditions, using media that are a standard supply worldwide, provide a reproducible and cost-effective approach that can accelerate research investigation and reduce the number of animal infections necessary for basic research of leptospirosis.

#2

Functional Validation of the Proteome-Identified LIC_13056 Putative Lipoprotein of Leptospira interrogans and the Potential Role in Pathogenesis.

International journal of molecular sciences2026 Feb 24

Leptospirosis is a widespread zoonosis of human and veterinary concern. The etiological agent of the disease is the pathogenic bacteria of the genus Leptospira. Transmission typically occurs through mucosal contact and/or injured skin with the urine of infected animals or contaminated environmental sources. Understanding the biology and pathogenesis of leptospires is the main focus of our study. In this work, we characterized a novel protein encoded by the LIC_13056 gene from L. interrogans serovar Copenhageni, having an OmpA-like domain. We show that this coding sequence (CDS), previously assigned as a hypothetical protein with an unknown function, is capable of binding to the cellular receptor α8 integrin subunit, potentially contributing to kidney colonization. Additionally, the protein bound to both purified and normal human serum (NHS) plasminogen (PLG). In both conditions, PLG bound to protein was able to generate plasmin (PLA). Furthermore, rLIC_13056 interacted with the complement system components C4b, C4BP, C8 and C9. The interaction of recombinant protein to the C9 had a negative impact on C9 polymerization. Taken together, the protein LIC_13056, having an OmpA-like domain, appears to be involved in leptospiral pathogenesis via different stages of the infection process; PLA generation together with the inhibition of the membrane attack complex (MAC) may contribute to the immune evasion mechanism of Leptospira, thus facilitating the infection.

#3

First report of pathogenic Leptospira in Sri Lankan bats: A potential reservoir risk?

PLoS neglected tropical diseases2026 Mar

The genus Leptospira, classified under the phylum Spirochaetes, includes saprophytic, intermediate, and pathogenic species. Pathogenic Leptospira spp. are the causative agents of leptospirosis, a widespread and often neglected zoonotic disease that causes severe illness in humans, particularly in tropical and subtropical regions. In Sri Lanka, leptospirosis causes annual outbreaks, especially during the monsoon seasons. While rodents are recognized as primary reservoirs, bats have also been identified as potential reservoir hosts. This study aimed to detect and characterize Leptospira species in bats roosting in Wavulgalge cave, Sri Lanka. Urine samples (n = 148) were collected during natural urination from four bat species: Miniopterus fuliginosus (n = 117), Hipposideros speoris (n = 8), Rousettus leschenaultii (n = 10), and Rhinolophus rouxii (n = 13). DNA was extracted and screened for Leptospira using real-time PCR targeting the lipL32 gene. Sixteen samples tested positive, including 14 from M. fuliginosus, one from H. speoris, and one from R. leschenaultii. Positive samples were further analyzed by amplifying additional loci (flaB, secY, and rrs2) for Sanger sequencing and phylogenetic analysis. Sequences were obtained from 12 samples. Leptospira borgpetersenii was identified in M. fuliginosus, while the sequence from R. leschenaultii represented a genetically distinct Leptospira species. Phylogenetic analysis showed clustering with sequences from the same bat host genera reported in other countries, and one L. borgpetersenii sequence clustered with strains previously detected in Sri Lankan hosts, including humans. This study provides the first molecular evidence of Leptospira in Sri Lankan bats and highlights their potential role as reservoirs contributing to the environmental circulation of pathogenic Leptospira.

#4

Bridging the gap: Multi-sector perspectives on human, domestic animal, and wildlife leptospirosis in Ontario, Canada.

PloS one2026

Although leptospirosis is one of the most common zoonotic diseases worldwide, limited surveillance and poor coordination between human and animal health sectors have resulted in scarce and disparate data on its occurrence. Strengthening integrated surveillance requires cross-sector collaboration, beginning with the engagement of key organizations. The aims of this study were to 1) determine key health experts' awareness and risk perceptions of leptospirosis and of zoonotic disease surveillance in Ontario, Canada, and 2) examine key components of engagement, such as perceived value and interest, during the initial stages of developing an integrated leptospirosis surveillance framework. A web-based survey was sent to 543 experts in human, animal, and environmental health in Ontario, and analyzed using a mixed-methods approach to identify key factors influencing perceptions of leptospirosis, including views on Leptospira distribution, the impact of human behavior, and the influence of environmental conditions. Leptospirosis was recognized as a health threat in Ontario by 90% (74/82) of respondents, and 91% (70/77) indicated that current surveillance efforts are inadequate. A higher proportion of animal health sector respondents identified leptospirosis as a threat to human (93%, 37/40) and animal health (90%, 44/49) compared to public health sector respondents (76%, 25/33 and 83%, 25/30, respectively). All participants (81/81) acknowledged the benefits of integrated surveillance over the current siloed approach. Our findings highlight that key public and animal health experts perceive leptospirosis as a health threat in Ontario and support more integrated disease surveillance to better respond to this emerging zoonotic pathogen.

#5

Pathogenic Leptospira species identified in dogs and cats during neutering in Thailand.

PLoS neglected tropical diseases2026 Feb

Pathogenic species of the genus Leptospira cause an underdiagnosed zoonosis in humans and animals called leptospirosis. Animal reservoirs often remain asymptomatic yet shed the active spirochete in urine, making the control of leptospirosis transmission to humans more challenging. Asymptomatic leptospirosis in human companions, such as dogs and cats, resulting in unrecognised infections, has been demonstrated in a few countries. Crucially, the current lack of molecular epidemiology data on Leptospira among companion animals in Thailand underscores the urgent need to investigate transmission dynamics for effective regional control. We investigated the prevalence of Leptospira infection in cats and dogs during neutering in seven provinces across Thailand. The urine samples were screened for Leptospira DNA by PCR targeting the rrs gene and further speciation using the Sanger Sequencing Analysis. The 56/567 (9.9%) animals were positive for Leptospira in the Pathogen clade, including 34/303 (11.2%) dogs and 22/264 (8.3%) cats. The partial rrs gene analysis identified L. interrogans, L. weilii, and L. borgpetersenii (4.4%) as well as Pathogen subclade 2 species (1.4%). Notably, this study reports the first molecular detection of L. yasudae (1.0%) in companion animals in Thailand. The identification of these three key pathogenic Leptospira species, common causes of human leptospirosis in Southeast Asia, in clinically healthy owned and free-roaming dogs and cats, suggests the risk of human leptospirosis in the areas investigated. These companion animals, often living in close contact with human, may contribute to daily risks. Therefore, enhanced surveillance and vaccination programs for dogs and cats, coupled with targeted public awareness campaigns, are critical for mitigating the risk of human infections.

Publicações recentes

One health perspectives on the epidemiological features and changing incidence of natural focus and vector-borne infectious diseases in China: An observational trend study.

One Health2026 Jun

Exploring Antileptospiral Agents of Phytochemicals from Cardiospermum Halicacabum Through In Silico Docking Approach.

Recent Adv Antiinfect Drug Discov2026 Apr 9

Wild Boar (Sus scrofa) as Reservoir of Pathogenic and Intermediate Leptospira.

Animals (Basel)2026 Mar 27

Development of an ELISA as a complement to MAT for swine leptospirosis diagnosis.

Res Vet Sci2026 Apr 2

Study of Leptospira spp. in rodents and water sources: implications for public health in rural environments from Buenos Aires province, Argentina.

Pathog Glob Health2026 Apr 10

Ver todas no PubMed

📚 EuropePMC6.340 artigos no totalmostrando 199

Biomedica : revista del Instituto Nacional de Salud

Acute pancreatitis due to Leptospira spp.: An uncommon case report of a common zoonosis.

Unique aspects of the acute kidney injury associated with infections in the tropics: presentation, challenges and opportunities.

Kidney international

Computers in biology and medicine

Hybrid neural-mechanistic modeling of leptospirosis transmission with environmental drivers: Evidence from Thailand.

Preventive veterinary medicine

Epidemiology and associated factors of human and canine leptospirosis in China: a systematic review and meta-analysis.

The American journal of tropical medicine and hygiene

Subclinical Leptospiral Infections and Antibody Waning During Pregnancy: A Population-Based Cohort Study from Rural Sri Lanka.

The Leptospira immunoglobulin-like protein LigB from Leptospira borgpetersenii serovar Arborea is not required for either acute or chronic infection.

Infection and immunity

Phylogenetic evidence of possible zoonotic circulation of Leptospira species between human febrile patients and bats within a same interface.

Brazilian journal of biology = Revista brasleira de biologia

First serological investigation of Toxoplasma gondii, Neospora caninum, Leishmania infantum and Leptospira spp. in dogs from a Fulni-ô Indigenous community in Pernambuco, Brazil: a One Health perspective.

DMEM and EMEM as alternate growth media for pathogenic Leptospira.

Clinical presentation and laboratory findings: key indicators for early diagnosis and severity prediction of leptospirosis in Sri Lanka.

International journal of molecular sciences

Functional Validation of the Proteome-Identified LIC_13056 Putative Lipoprotein of Leptospira interrogans and the Potential Role in Pathogenesis.

CRISPR-based mutagenesis of lipopolysaccharide biosynthesis genes in Leptospira interrogans reveals gene essentiality and confirms the role of an O-antigen polymerase.

Scientific reports

Operationalizing the One Health approach in a conflict-affected setting: A scientometric review of policy foundations, systemic gaps, and future pathways in Ukraine.

Veterinary world

Medical journal, Armed Forces India

A tale of dual battle against leptospira and scrub typhus coinfection at a peripheral hospital in Kashmir.

The Journal of the Association of Physicians of India

Clinical and Laboratory Profile of Patients with Tropical Coinfections Admitted at a Tertiary Care Center in North India.

Australian veterinary journal

Risk of infection in dogs in contact with clinical canine leptospirosis cases.

Open forum infectious diseases

Leptospirosis Incidence at Four Sites in Sub-Saharan Africa and South East Asia: An International Multi-Site Hybrid Surveillance Study.

IMPACT OF THE COVID-19 PANDEMIC ON THE SURVEILLANCE OF INFECTIOUS DISEASES: ASSESSMENT OF THE LEPTOSPIROSIS SURVEILLANCE SYSTEM IN THE ADJARA REGION (2020-2024).

Georgian medical news

Journal of medical microbiology

Association between spirochaetal infection and neurodegenerative diseases: a systematic review and quantitative synthesis of observational studies.

Journal of medical microbiology

Molecular epidemiology of rodent-borne Leptospira spp. in Sri Lanka: identification of novel sequence types and previously unrecognized reservoir animals.

First report of pathogenic Leptospira in Sri Lankan bats: A potential reservoir risk?

Journal of occupational medicine and toxicology (London, England)

Prevalence of antibodies against hantavirus, Leptospira, lymphocytic choriomeningitis virus and Chlamydia psittaci in pest control workers in Germany - a cross-sectional study.

Archives of Razi Institute

Expanded Leptospirosis Syndrome - An Unusual Case.

Bulletin of the World Health Organization

Flood preparedness and public health policy, Greece.

Vector borne and zoonotic diseases (Larchmont, N.Y.)

Emergence of a Highly Pathogenic Leptospira Serogroup 56601 Revealed by 15-Year Surveillance and Experimental Validation in a Rural Area of Zhejiang Province, China.

Discovery of Novel c-di-GMP-Related Genes in Leptospira interrogans.

Molecular Detection and Genotyping of Pathogenic Leptospira in Small Mammals from Southern Vietnam.

Leptospirosis in Central Romania: A 17-Year Single-Center Cohort Study of Hospitalized Adults.

Leptospira interrogans HtrA protease is a potent inducer of multifaceted cellular responses.

Antonie van Leeuwenhoek

Factors Associated with the Prevalence of Dengue-Leptospirosis Coinfection in Patients Hospitalized for Febrile Syndrome.

Transactions of the Royal Society of Tropical Medicine and Hygiene

Trend of zoonotic diseases outbreaks in India: a secondary data analysis of Integrated Disease Surveillance Programme data, 2010-2023.

Ictero-hemorrhagic leptospirosis -Weil's disease.

The Leptospira interrogans CdaA protein is a functional diadenylate cyclase.

Infection and immunity

Practical laboratory medicine

Evaluation of the Truenat® chip-based real-time PCR platform for infectious disease diagnostics.

Frontiers in cellular and infection microbiology

Computational identification of natural inhibitors targeting GroEL in Leptospira interrogans: an integrative virtual screening and molecular dynamics approach.

Journal of microbiological methods

Corrigendum to <'Evaluation of anti-LipL32 carbon nanotube immunofluorescence probe (carbo-lip) and comparison with MAT, IgM ELISA, IgM spot test and culture for early detection of leptospirosis at local hospital'> <[Journal of Microbiological Methods 195 (2022) 106448]>.

Prioritization of zoonotic diseases in Bhutan through a One Health framework.

One health outlook

bioRxiv : the preprint server for biology

Core-sheath coupling controls flagellar curvature and motility in Leptospira.

Zoonoses and public health

Bayesian Estimation of True Prevalence and Associated Risk Factors for Leptospira spp. Among Slaughterhouse Workers and Slaughtered Cattle in the Bahr El Ghazal Region of South Sudan.

Immunoinformatics design and in vivo evaluation of a multiepitope vaccine targeting OMPL1, Lipl32, Lipl41, and Lipl46 for leptospirosis in a male ICR mouse model.

Investigating the existing analytical methods deployed for leptospirosis detection and diagnostics.

The Analyst

The American journal of tropical medicine and hygiene

Acute Undifferentiated Febrile Illness in Hospitalized Adults in Western and Central Provinces, Sri Lanka: High Levels of Coinfections and Clinical Misdiagnoses of Etiology.

Tropical medicine & international health : TM & IH

Leptospirosis: Unveiling the Hidden Threat in a Non-Endemic Region of India.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Advances in ELISA-based detection of equine leptospirosis.

Australian and New Zealand journal of public health

A One Health approach to leptospirosis: Current serosurveillance practices and climate change leave Australia at increasing risk.

Computers in biology and medicine

Probing the conserved catalytic mechanism of ThiL protein in pathogenic Leptospira species: An in silico strategy for inhibitor discovery to combat leptospirosis.

Combined Biospectroscopy with Multivariate Analysis for the Differential Diagnosis of Leptospirosis Disease: A Pilot Study.

ACS omega

Diagnosis of Equine Genital Leptospirosis (EGL) in mares with poor reproductive performance.

Veterinary microbiology

Bridging the gap: Multi-sector perspectives on human, domestic animal, and wildlife leptospirosis in Ontario, Canada.

PloS one

Severe neurological complications of leptospirosis, presentation of two cases.

Open forum infectious diseases

Epidemiology, Management, and Outcomes of Patients Hospitalized With Community-Acquired Infection in a Resource-Limited Setting in Southeast Asia: A Prospective Observational Study.

Pathogenic Leptospira species identified in dogs and cats during neutering in Thailand.

Revista do Instituto de Medicina Tropical de Sao Paulo

Leptospirosis-associated pulmonary hemorrhagic syndrome: immune mechanisms, clinical manifestations, and experimental models.

Effect of a gut commensal Lactobacillus strain Limosilactobacillus caviae JL20 on leptospiral whole-cell inactivated vaccine in hamsters.

Application of leptospirosis surveillance study at primary health care center in Banyumas and Demak, Central Java, Indonesia.

Open veterinary journal

Indian journal of public health

Investigation of Outbreak of Leptospirosis in a Village in Koraput, Odisha, 2024.

Research and practice in thrombosis and haemostasis

Clinical characteristics of thrombocytopenia in tropical diseases and management in resource-limited settings.

Serological and molecular evidence of Leptospira spp. in martens from Poland.

BMC veterinary research

Applied and environmental microbiology

Leptospira prevalence and lineages vary across land-use types due to shifts in small mammal communities.

Frontiers in public health

Development of One Health-based community surveillance system to study zoonotic diseases: a study protocol.

Frontiers in public health

Finding the hiding spots: uneven distribution of pathogenic Leptospira spp. in the bovine genital tract.

Direct, indirect and intangible costs incurred by leptospirosis patients: the magnitude, aspects and methods of assessing the costs - a systematic review and meta-analysis protocol.

BMJ open

In vitro and in vivo endothelial interactions of Leptospira species are markers of virulence.

Leptospirosis in Southeast Asia: Investigating Seroprevalence, Transmission Patterns, and Diagnostic Challenges.

Concurrent Scrub Typhus, Dengue, and Leptospirosis: A Rare Triple Co-Infection: A Case Report and Comprehensive Literature Review.

Clinical case reports

Advances in protein chemistry and structural biology

Unraveling the role of antimicrobial proteins in leptospirosis: A comprehensive transcriptomic analysis.

International journal of medical microbiology : IJMM

Genomic comparison of Leptospira interrogans isolated from humans, dogs, and wild and feral animals in Japan.

Journal of medical case reports

Secondary hemophagocytic lymphohistiocytosis in a patient with severe leptospirosis: a case report.

World journal of microbiology & biotechnology

Comprehensive genotyping and taxonomic analysis uncovers extensive distribution of intermediate Leptospira species in Colombia.

Development of a Mobile App (MyLepto App) to Improve Knowledge, Attitude, and Practice Regarding Leptospirosis Among Wet Market Workers in Selangor, Malaysia: Protocol for a Quasi-Experimental Study.

JMIR research protocols

Recent advances in inflammation & allergy drug discovery

Clinical Profile and Severity Correlation of Acute Leptospirosis in Northern India, 2019-2023: A Tertiary Care Center-based study.

Annals of African medicine

Distinguishing Leptospirosis from Other Causes of Acute Encephalitis Syndrome: Clinical Insights.

Hyperferritinemia Drives Risk: Unravelling the Association Between Ferritin Levels and Multi-Organ Dysfunction in Acute Febrile Illness: An Emergency Medicine Perspective.

Infectious diseases of poverty

Evaluating the diagnostic accuracy of clinical judgement and rapid tests for leptospirosis in the Philippines: implications for public health management.

Veterinary research communications

Molecular surveillance of Leptospira infection in domestic dogs in Soledad, Northern Colombia.

Invasive alien mammals pose zoonotic risks to human health in Europe.

Transboundary and emerging diseases

Host-Driven Genetic Diversity of Leptospira in the Americas: A Continental Perspective.

Spatio-temporal dynamics of leptospirosis in Brazil between 2010 and 2023: Identifying high-risk regions and gender-specific patterns.

Acta tropica

Critical reviews in microbiology

Pathogenesis of leptospirosis-induced coagulopathy and hemorrhages.

Leptospirosis Complicated by Haemorrhagic Cardiac Tamponade: A Challenging Case of Weil's Disease.

Spatiotemporal patterns and climate influences on leptospirosis in Sri Lanka from 2009 to 2024.

Veterinary journal (London, England : 1997)

The genital route in experimental infection with Leptospira spp. in hamsters as a model for genital leptospirosis.

Evaluation of a recombinant Loa22-gold nanoparticle based lateral flow assay for the serodiagnosis of leptospirosis in canine and bovine.

Archives of microbiology

A Life-Threatening Case of Severe Leptospirosis in Wales, UK: Recognising Severe Disease in Non-endemic Settings.

Early diagnosis and treatment of leptospirosis: Optimizing clinical outcomes.

The Journal of infection

Leptospirosis in France: time to revise diagnostic algorithms and their reimbursement.

Infectious diseases now

Evaluation of Laboratory Techniques for the Diagnosis of Leptospira-Associated Equine Recurrent Uveitis (ERU) With Focus on the Goldmann-Witmer Coefficient.

Veterinary ophthalmology

Impact of nonpharmaceutical interventions on infectious disease patterns in Yunnan Province across the COVID-19 pandemic phases.

Severe leptospirosis in the intensive care unit: single centre prospective cohort study from Sri Lanka.

Typhoid Fever in Indonesia: Pitfalls in the Diagnosis of Typhoid Fever.

Acta medica Indonesiana

Spatiotemporal patterns and clinical characteristics of leptospirosis hospitalizations in Ecuador: a nationwide study (2018-2023).

Acta tropica

cGAS-STING dependent type I IFN reduces Leptospira interrogans renal colonization in mice.

PLoS pathogens

Indian journal of pharmacology

Outer membrane protein LipL21 as a potential candidate against Leptospira interrogans: An in silico prediction.

Severe meningococcaemia mimicking leptospirosis: a diagnostic challenge in a tropical setting.

BMJ case reports

Posterior reversible encephalopathy syndrome in a child with leptospira-associated glomerulonephritis: the 3 P'S framework.

BMJ case reports

New microbes and new infections

A case of disseminated intravascular coagulation by leptospirosis during the ongoing yellow fever outbreak in Colombia.

A one health approach to prioritizing emerging zoonotic diseases (EZDs) in northern Vietnam.

Projecting long-term excess risks of major infectious diseases associated with future extreme weather events in Thailand.

Journal of visualized experiments : JoVE

A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms.

Leptospirosis in the Caribbean Region between 2000 and 2022: A scoping review of morbidity and mortality.

Leptospira and Leptospirosis: A Review of Species Classifications, Genomes, Morphological Structures, Antimicrobial Resistances, Transmissions, and Clinical Manifestations.

Current microbiology

Electrocardiographic Abnormalities in Patients With Leptospirosis: A Clinical Observational Study.

Detection of Leptospira in cane toads (Rhinella jimi) from urban and rural Paraíba, Brazil.

The Veterinary record

Journal of intensive care

Extracorporeal membrane oxygenation support for tropical infections: a scoping review.

Tropical medicine and health

Francisella spp. as an overlooked cause of acute undifferentiated febrile illness in Colombia? Unexpected evidence from febrile patients negative for other common and neglected etiologies in Villeta municipality.

Mymensingh medical journal : MMJ

Prediction of Clinical Features and Outcome of Leptospirosis associated AKI according to Acute Kidney Injury Net work Classification in a Tertiary Care Hospital of Bangladesh.

Lung India : official organ of Indian Chest Society

Leptospirosis: An unusual cause of pulmonary haemorrhage and multi-organ failure.

Leptospirosis in the Delta Region of Tamil Nadu: A Retrospective Analysis in South India.

The Characteristics of Patients That Develop Severe Leptospirosis: A Scoping Review.

The Indian journal of medical research

Emergence of human leptospirosis in Meghalaya, India: Clinical evidence from a hilly non-endemic region.

mRNA vaccines targeting Leptospira immunoglobulin-like proteins confer partial protection in a hamster model of leptospirosis.

Equine veterinary journal

Equine leptospiral pulmonary haemorrhage syndrome: An atypical manifestation of equine leptospirosis.

The role of leptospiral proteins in immune evasion and inflammatory response stimulation in HEK293T cell monolayers.

Frontiers in immunology

A self-assembled Pirococcus abyssi exosome complex displaying outer membrane proteins of Leptospira interrogans elicits protective immunity against leptospirosis.

Lung Involvement in Patients with Leptospirosis in Tropical Australia; Associations, Clinical Course and Implications for Management.

JMIR public health and surveillance

Transforming One Health in India: National Multisectoral Mixed Method Study on Prioritization of Zoonotic Diseases.

Animal reproduction science

First detection of Leptospira spp. in cumulus-oocyte complexes from naturally infected cows.

The Science of the total environment

Corrigendum to "Rainfall-driven resuspension of pathogenic Leptospira in a leptospirosis hotspot" [Sci. Total Environ. (2024) 168700].

Whole-genome sequencing as a regulatory tool for quality control of Leptospira strains for vaccines and diagnostics.

Human leptospirosis in northern Iran: a population-based epidemiological study using infectious disease surveillance system data.

BMC research notes

Delayed psychiatric sequelae following multifocal central nervous system lesions in leptospirosis: A case report.

Preventive veterinary medicine

An economic framework for One Health investment: A critical tool for decision makers.

Transboundary and emerging diseases

Seroprevalence and Molecular Epidemiology of Leptospira spp. Infecting Dogs in the Yangtze River Region of China.

Journal of feline medicine and surgery

Evaluation of Leptospira species as a cause of endogenous uveitis in cats: a pilot study.

JPMA. The Journal of the Pakistan Medical Association

Leptospirosis in a male patient with systemic lupus erythematosus: A case report.

Frontiers in public health

Design and set-up of the leptospirosis registry LeptoScope for epidemiology, outbreaks and clinical studies on human leptospirosis.

Journal of preventive medicine and public health = Yebang Uihakhoe chi

The Role of Hydrometeorological Factors in Leptospirosis Transmission in Central Java, Indonesia.

[Two cases of indigenous leptospirosis in Sweden].

Lakartidningen

Impacts of infectious diseases on movement metrics in a large carnivore: Highly pathogenic avian influenza, leptospirosis, and pumas.

iScience

Veterinary research communications

Seroprevalence of pathogenic leptospira in domiciled and stray dogs from subtropical Mexico.

Detection of P1 and P2 Subclades of Leptospira carriage in swine in Sri Lanka.

BMC veterinary research

Culture-attenuated pathogenic Leptospira lose the ability to survive complement lytic activity due to decreased C4BP uptake.

Microbes and infection

Journal of clinical microbiology

Revisiting genital leptospirosis in large animals: impacts on reproductive health, diagnostic challenges, and future directions.

Vector borne and zoonotic diseases (Larchmont, N.Y.)

Reactive Arthritis Due to Leptospirosis in a 11-Year-Old Adolescent Boy.

Clinical microbiology reviews

Floods and infectious diseases: public health lessons from the 2024 southern Brazil disaster.

Leptospirosis: First Reported Case in Lebanon.

Recombinant chimeric proteins offer new hope to control of leptospirosis.

The Medical journal of Malaysia

Leptospirosis in Perak state for the year 2024: Hospitalisation rate and its associated factors.

Using step selection functions to analyse human mobility using telemetry data in infectious disease epidemiology: a case study of leptospirosis.

eLife

A case report of leptospirosis complicated by severe pulmonary hemorrhage treated with venovenous extracorporeal membrane oxygenation.

Frontiers in medicine

Alternative Sigma Factors of RNA Polymerase as Master Regulators in the Pathogenic Spirochaete Leptospira interrogans.

Five Leptospira spp. Antibody Point-of-Care Tests in Healthy Dogs Reveal Different Results After Revaccination Against Leptospirosis.

Genetic Diversity and Clonal Expansion of Pathogenic Leptospira in Brazil: A Multi-Host and Multi-Regional Panorama.

Flushing away disease: A one health perspective on sanitation, pathogen transmission, and rural health in China.

Veterinary research communications

Serological profile of infectious bovine rhinotracheitis, bovine viral diarrhea, leptospirosis, toxoplasmosis, and neosporosis in beef cattle herds in Tocantins, Northern Brazil.

Journal of medical primatology

A Guidance for Diagnosis, Control Measures, and Surveillance of Leptospirosis in Non-Human Primates From a Veterinary Perspective in a One-Health Approach.

Leptospirosis seroprevalence and exposure factors in three informal settlements of French Guiana: An opportunistic survey.

A Rare Case of Triple Infection with Leptospira, Hepatitis A Virus, and Hepatitis E Virus.

Reports (MDPI)

Atypical presentation of leptospirosis as aseptic meningitis in an immunocompromised patient: Impact of rituximab on recovery and prolonged inflammatory response.

The Lancet regional health. Western Pacific

Risk of dengue following prior SARS-CoV-2 infection: a population-based cohort study.

New microbes and new infections

Amazon environment sharing featuring humans - dogs - capybaras and more. Adapting a one-health approach to leptospirosis prevention in Indigenous riverine communities in Ecuador and beyond.

Case reports in infectious diseases

Bowel Necrosis in Leptospirosis: A Case Series of a Rare Complication.

Evaluation of the conserved subunit of the pathogenic Leptospira FlaB protein-based immunochromatographic test for the diagnosis of acute leptospirosis.

Microbiology spectrum

Preventive veterinary medicine

Canine leptospirosis and environmental risk factors in coastal New South Wales, Australia (2021 - 2023).

Co-expression network insights into Leptospira interrogans pathogenesis.

Research in microbiology

Zoonoses and public health

Genotyping Reveals Potential Sources of Human Leptospirosis Outbreaks in Aotearoa New Zealand.

Proceedings. Biological sciences

When science remembers what is neglected: addressing the risks of rodent-borne diseases in urban Latin America.

Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronic Leptospira interrogans infection.

Infection and immunity

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica

Exploring Eugenol as a Growth and Biofilm Inhibitor in Leptospira interrogans by a Combined Experimental and Computational Approach.

World journal of microbiology & biotechnology

Isolation of DNA aptamers by Tripartite-hybrid-high throughput SELEX (Tripartite-hybrid-HT SELEX) for the detection of pathogenic Leptospira.

Neonatal tropical infections: A case series and clinical insights.

Tropical doctor

The journal of the Royal College of Physicians of Edinburgh

Leptospiral infection overlapping with autoimmune hepatitis: A diagnostic conundrum.

Global Perspective on Acute Kidney Injury in Nepal.

Kidney360

Journal of clinical and experimental hepatology

Plasma Exchange to Treat Severe Leptospirosis With Cholestasis and Renal Failure - A Case Report and Review of Literature.

FEMS microbiology reviews

Look and you will find-a literature review of new strains of Leptospira spp., 2000-2025.

The American journal of tropical medicine and hygiene

Early Diagnosis of Human Leptospirosis by Detection of Antibodies to Leptospira-Secreted Virulence-Modifying Protein Exotoxins.

PLOS global public health

Sea surface temperature modulates El Niño and La Niña driven leptospirosis patterns: Evidence from causal machine learning in Colombia.

Distinct strategies of epithelial cell barrier disruption by Leptospira interrogans isolated from human patients in Okinawa, Japan.

Ecological range and host-biome associations of pathogenic Leptospira in Brazil: A One Health perspective from a tropical area.

Acta tropica

Cellular senescence links severe Leptospira infection to chronic kidney disease progression.

Life sciences

Iranian journal of veterinary research

Seroprevalence and carrier status of Leptospira spp. in rats captured in the central northern region of Algeria.

Journal of clinical microbiology

Diagnosis of leptospirosis in animals: challenges and perspectives.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases

Regional burden of undifferentiated fever and leading infectious etiologies of acute febrile illness in low- and middle-income countries: a meta-analysis.

Bioinformatic Identification of CRISPR-Cas Systems in Leptospira Genus: An Update on Their Distribution Across 77 Species.

Spotted Fever Rickettsioses in Panama: New Cases and the Gaps That Hinder Its Epidemiological Understanding.

Leptospirosis in the Philippines: Confronting the Structural Roots of a Recurring Threat.

Animals : an open access journal from MDPI

A Scoping Review of Antimicrobial Therapy in Leptospira Infections in Domestic Animals.

Comparative immunology, microbiology and infectious diseases

Modeling and field-derived insights into canine leptospirosis in feral and domestic dogs of Texcoco, Mexico: A One Health approach.

Comparative immunology, microbiology and infectious diseases

Vaccination with monovalent Leptospira interrogans serovar Copenhageni and its implication for the diagnosis of natural infection in dogs.

Impact of El Nino Southern Oscillation and Climate Change on Infectious Diseases with Ophthalmic Manifestations.

Endemicity, Clinical Features, Risk Factors, and the Potential for Severe Infection in Leptospira wolffii-Associated Leptospirosis in North-Central Bangladesh.

Deciphering Microscopic Agglutination Test (MAT) Serogroup Cross-Reactivity in Leptospirosis: The Influence of Age and Antibody Titers.

Emerging human and canine leptospirosis in New South Wales: insights from a One Health geospatial study.

Science in One Health

Brain, behavior, & immunity - health

Combined effects of calorie restriction and chronic stress on systemic inflammation and gut microbiota in rats exposed to Leptospira interrogans lipopolysaccharide.

A Rare Case Report of COVID-19 and Leptospirosis Co-infection Triggering Acute Myocarditis.

The Successful Management of Severe Leptospirosis by Using Meropenem and Corticosteroids in the Setting of Multi-Drug Hypersensitivity: A Case Report.

The American journal of tropical medicine and hygiene

Unprecedented Surge of Melioidosis after Typhoon Events in Taiwan 2024.

The American journal of tropical medicine and hygiene

Potential for Early Diagnosis of Leptospirosis in Experimentally Infected Rhesus Macaques Based on Detection of Leptospiral Virulence-Modifying Protein Exotoxin Antigen and Antibody.

Comparative analysis of acute kidney injury in tropical infections: A retrospective cohort study.

Tropical doctor

International urology and nephrology

Leptospirosis-associated acute kidney injury in Odisha, India.

Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]

Leptospira licerasiae, a zoonotic pathogen isolated from water sources in Santa Maria, Rio Grande do Sul, Brazil.

Geospatial mapping and risk factor analysis of Leptospira interrogans serovar Canicola Portland Vere in backyard cattle in Chiapas, Mexico.

Veterinary world

Describing diagnosis (MAT + PCR) and control (vaccine + streptomycin sulfate) of a leptospirosis outbreak in dairy cows with reproductive disorders.

Animal reproduction

Leptospira interrogans serovar Copenhageni infection and exudative glomerulonephritis in rehabilitated gray seals (Halichoerus grypus) and harbor seals (Phoca vitulina) in Ireland.

Veterinary microbiology

Veterinary medicine and science

Leptospirosis Seroprevalence in Humans and Livestock of East Africa: A Systematic Review and Meta-Analysis (2000-2024).

Leptospira interrogans biofilms in acute canine infection and their in vitro interactions with antibiotics and p-coumaric acid.

Veterinary microbiology

The Journal of infectious diseases

Leptospirosis Prevalence and Risk Factors Among Patients Presenting With Fever to 4 Healthcare Sites in Sub-Saharan Africa and South East Asia: An International Multisite Observational and Nested Case-Control Study.

Travel medicine and infectious disease

Leptospirosis in the United Kingdom: a decade of experience from a large regional hospital.

Ver todos os 6.340 no EuropePMC

A Diagnostically Challenging Leptospirosis Case in a Serviceman in a Combat Zone.

Military medicine

Próxima:Associações

Associações

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Doença com base genética

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Próxima:Doenças relacionadas

Doenças relacionadas

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Febre Q

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Febre hemorrágica Crimeia-Congo (CCHF)

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Peste

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Legionelose

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Doença do Legionário