Functional outcome after vertical parasagittal hemispherotomy in pediatric hemimegalencephaly: Insights from a single case.

Adjunctive cannabidiol in intractable pediatric epilepsy: A retrospective study on tolerability, efficacy, and safety across genetic and nongenetic etiologies.

Hemispherectomy in infants: an institutional experience with 21 patients.

Improvement in post-hemispherotomy cerebral salt-wasting syndrome following intubation: A case report.

A novel PTEN variant causing hemimegalencephaly and focal nodular heterotopias in the developing human brain.

Malformations of cortical development on fetal MRI.

Clinical and radiological evaluation of children with hemimegalencephaly and epilepsy: A single-center study.

Transarterial embolization versus hemispherectomy in infants with hemimegalencephaly and drug-resistant epilepsy.

Associations between fever following hemispherotomy, surgeon experience, and increased CSF protein.

Phase 1 study of ABI-009 (nab-rapamycin) for surgically refractory epilepsy (RaSuRE).

Electrical Status Epilepticus in Sleep in a Patient with Hemimegalencephaly and Tuberous Sclerosis Complex.

Transarterial embolization for infants under 3 months of age with refractory seizures due to hemimegalencephaly: complication analysis and evolution of treatment strategy.

mTORopathies in Epilepsy and Neurodevelopmental Disorders: The Future of Therapeutics and the Role of Gene Editing.

Uncrossed Cerebellar Diaschisis in Hemimegalencephaly: Evaluated by FDG-PET and Diffusion Tensor Tractography.

Corpus Callosotomy for Atonic Drop Seizures in Bilateral Malformations of Cortical Development: A Systematic Review of Literature.

Effectiveness and Safety of High-Dose Oral Phenobarbital in Children With Recurrent and Treatment-Refractory Seizures.

The fetal neurologist: Strategies to improve training, practice, and clinical care.

A Novel RHEB Germline Variant Associated With Intellectual Disability and Epilepsy: Expanding the Spectrum of mTORopathies.

Cytomegalic parvalbumin neurons in fetal cases of hemimegalencephaly.

The genetic landscape and classification of infantile epileptic spasms syndrome requiring surgery due to suspected focal brain malformations.

Newborn with Refractory Seizures due to Hemimegalencephaly and Tuberous Sclerosis Complex: Case Report and Literature Review.

Lopsided brain: a case of hemispheric dysplasia with cortical malformation in an infant.

Epileptiform discharges in the context of self-limited pediatric focal epilepsy (EDSelFEC) in pediatric hemispherotomy patients: Role of white matter abnormalities.

A case of acute functional hemispherotomy in a young woman with hemimegalencephaly and super-refractory status epilepticus.

Somatic variant analysis of resected brain tissue in epilepsy surgery patients.

Facial infiltrating lipomatosis with contralateral hemimegalencephaly.

Multi-disciplinary team approach for pediatric hemimegalencephaly: Insights from a single institutional case series.

[Malformations of cortical development: what's new?].

Alterations of the AKT Pathway in Sporadic Human Tumors, Inherited Susceptibility to Cancer, and Overgrowth Syndromes.

Transsylvian transopercular peri-central core hemispherotomy for treating epilepsy: anatomy, surgical technique, and clinical outcome.

Chloride deregulation and GABA depolarization in MTOR-related malformations of cortical development.

Hemispheric surgery in children: perisylvian technique.

Vertical Parasagittal Hemispherotomy.

Prenatal diagnosis of hemimegalencephaly via transabdominal and transvaginal ultrasonography: a case description.

Prenatal Diagnosis of Hemimegalencephaly Using Radiological Methods: A Case Report.

PAEDIATRIC SYMPTOMATIC SEIZURES IN INDIA: UNRAVELLING VARIED ETIOLOGIES AND NEUROIMAGING PATTERNS - A MULTICENTRIC STUDY.

Allelic heterogeneity in a patient with postzygotic MTOR-related hypomelanosis of Ito with neurodevelopmental abnormalities.

Clinical characteristics and surgical management of facial infiltrating lipomatosis: a single center experience.

Neuroimaging Findings in Fetal Hemimegalencephaly: Case Study and Review.

Interhemispheric Vertical Hemispherotomy: Technique, Outcome, and Pitfalls-A Bicentric Retrospective Case Series of 39 Cases.

Hemimegalencephaly: A Systematic Comparison of Functional and Anatomic Hemispherectomy for Drug-Resistant Epilepsy.

Tandem pediatric neurosurgery: treatment of synostosis and intractable epilepsy. Illustrative case.

Molecular characterization of 13 patients with PIK3CA-related overgrowth spectrum using a targeted deep sequencing approach.

mTOR Pathway Somatic Pathogenic Variants in Focal Malformations of Cortical Development: Novel Variants, Topographic Mapping, and Clinical Outcomes.

Hemispheric epilepsy surgery for hemimegalencephaly: The UCLA experience.

Predicting seizure outcomes and functional outcomes after hemispherotomy: are we any better?

Contralateral hippocampal sclerosis following functional hemispherectomy in children: A report of three cases.

Variants in PTEN Are Associated With a Diverse Spectrum of Cortical Dysplasia.

A novel approach to seizures in neonates.

Neuroectodermal Diseases: A Comparative Case Report Study.

Delineation of the phenotypes and genotypes of facial infiltrating lipomatosis associated with PIK3CA mutations.

The somatic p.T81dup variant in AKT3 gene underlies a mild cerebral phenotype and expands the spectrum including capillary malformation and lateralized overgrowth.

Technological and computational approaches to detect somatic mosaicism in epilepsy.

Vertical Hemispherotomy: Contribution of Advanced Three-Dimensional Modeling for Presurgical Planning and Training.

Facial infiltrating lipomatosis with hemimegalencephaly and lymphatic malformations caused by nonhotspot phosphatidylinositol 3-kinase catalytic subunit alpha mutation.

mTOR pathway: Insights into an established pathway for brain mosaicism in epilepsy.

Congenital Infiltrating Lipomatosis of Face Associated with Ipsilateral Hemimegalencephaly: An Uncommon Cause for Facial Asymmetry in a Child.

Hemispherotomy in an infant with hemimegalencephaly and Ohtahara syndrome.

An Initial Experience of Completion Hemispherotomy via Magnetic Resonance-Guided Laser Interstitial Therapy.

Pathogenic RHEB Somatic Variant in a Child With Tuberous Sclerosis Complex Without Pathogenic Variants in TSC1 or TSC2.

mTOR-therapy and targeted treatment opportunities in mTOR-related epilepsies associated with cortical malformations.

Not surgical technique, but etiology, contralateral MRI, prior surgery, and side of surgery determine seizure outcome after pediatric hemispherotomy.

A case report of hemimegalencephaly with super-refractory status epilepticus and brain atrophy associated with NPRL3 gene mutation.

Hemispherotomy in Infants with Hemimegalencephaly: Long-Term Seizure and Developmental Outcome in Early Treated Patients.

Prenatal diagnosis and delivery of megalencephaly-capillary malformation syndrome.

Somatic mosaicism of the PI3K-AKT-MTOR pathway is associated with hemimegalencephaly in fetal brains.

Definitive treatment of seizures due to hemimegalencephaly in neonates and young infants by transarterial embolization: technical considerations for 'endovascular embolic hemispherectomy'.

Neuroimaging features of genetic syndromes associated with CNS overgrowth.

Hemimegalencephaly: Evolution From an Atypical Focal Early Appearance on Fetal MRI to More Conventional MR Findings.

Refractory neonatal seizures caused by hemimegalencephaly.

The changing landscape in epilepsy imaging: Unmasking subtle and unique entities.

Prevalence and Risk Factors for Pharmacoresistance in Children With Focal Cortical Dysplasia-Related Epilepsy.

Functional hemispherotomy for epilepsy in the very young.

A rare case of hemimegalencephaly diagnosed prenatally.

Periodic cycles of seizure clustering and suppression in children with epilepsy strongly suggest focal cortical dysplasia.

Postmortem Diagnosis of the Proteus Syndrome by Next Generation Sequencing of Affected Brain Tissue.

Adult Hemimegalencephaly with Migraine as the First Symptom.

Infection-Induced Elevated Plasma Perampanel in a Patient with Hemimegalencephaly.

The utility of cerebrospinal fluid-derived cell-free DNA in molecular diagnostics for the PIK3CA-related megalencephaly-capillary malformation (MCAP) syndrome: a case report.

Somatic variants in diverse genes leads to a spectrum of focal cortical malformations.

Profiling PI3K-AKT-MTOR variants in focal brain malformations reveals new insights for diagnostic care.

Prenatal MR Imaging Phenotype of Fetuses with Tuberous Sclerosis: An Institutional Case Series and Literature Review.

Efficacy of Ketamine Use in Refractory Status Epilepticus Associated With Hemimegalencephaly.

Cortical Dysplasia and the mTOR Pathway: How the Study of Human Brain Tissue Has Led to Insights into Epileptogenesis.

Treatment of two infants with PIK3CA-related overgrowth spectrum by alpelisib.

Hemispherectomy for hemimegalencephaly in a 6.5-week-old infant with tuberous sclerosis complex.

Neurodevelopmental Findings and Epilepsy in Malformations of Cortical Development.

Case Report: Hemispherotomy in the First Days of Life to Treat Drug-Resistant Lesional Epilepsy.

Ictal and Interictal Arterial Spin Labelling (ASL) in Hemimegalencephaly.

Hemimegalencephaly: A rare congenital malformation of cortical development.

Viral expression of constitutively active AKT3 induces CST axonal sprouting and regeneration, but also promotes seizures.

[Lessons learnt from 101 hemispheric pediatric epilepsy surgeries part ii: pitfalls and complications].

Magnetic Resonance Imaging of Malformations of Cortical Development-A Comprehensive Review.

Vertical hemispherotomy for drug-resistant epilepsy: Toward confirmation of the HOPS study.

[Lessons learnt from 101 hemispherotomies in children with symptomatic epilepsy. Part I: seizure outcome].

Identification of a recurrent mosaic KRAS variant in brain tissue from an individual with nevus sebaceous syndrome.

Epilepsy Surgery: Special Circumstances.

Functional cognitive and language outcomes after cerebral hemispherectomy for hemimegalencephaly.

Precision Therapy for Epilepsy Related to Brain Malformations.

[Genotype and phenotype of children with DEPDC5 gene variants related epilepsy].

Endoscopic Hemispherotomy for Nonatrophic Rasmussen's Encephalopathy.

Role of epilepsy surgery in refractory status epilepticus in children.

Postoperative seizure and developmental outcomes of children with hemimegalencephaly and drug-resistant epilepsy.

Epilepsy surgery in children under 3 years of age: surgical and developmental outcomes.

Brain Tissue Low-Level Mosaicism for MTOR Mutation Causes Smith-Kingsmore Phenotype with Recurrent Hypoglycemia-A Novel Phenotype and a Further Proof for Testing of an Affected Tissue.

Vertical parasagittal hemispherotomy: a case report of postoperative mesio-temporal seizures via amygdalofugal pathway.

Clinical and molecular data in cases of prenatal localized overgrowth disorder: major implication of genetic variants in PI3K-AKT-mTOR signaling pathway.

Epilepsy surgery in infants up to 3 months of age: Safety, feasibility, and outcomes: A multicenter, multinational study.

PTEN somatic mutations contribute to spectrum of cerebral overgrowth.

Functional hemispherectomy: can preoperative imaging predict outcome?

The Fetus with Ganglionic Eminence Abnormality: Head Size and Extracranial Sonographic Findings Predict Genetic Diagnoses and Postnatal Outcomes.

Epileptic children with hemispheres' asymmetry. Quantitative brain magnetic resonance-based analysis of apparently unaffected hemisphere. Case-control study.

Clonally Focused Public and Private T Cells in Resected Brain Tissue From Surgeries to Treat Children With Intractable Seizures.

Detection of Brain Somatic Mutations in Cerebrospinal Fluid from Refractory Epilepsy Patients.

Clinical spectrum of MTOR-related hypomelanosis of Ito with neurodevelopmental abnormalities.

Robotic thermocoagulative hemispherotomy: concept, feasibility, outcomes, and safety of a new "bloodless" technique.

Rasmussen's encephalitis with persistent epilepsy in a young man.

Neuroimaging and genetic characteristics of malformation of cortical development due to mTOR pathway dysregulation: clues for the epileptogenic lesions and indications for epilepsy surgery.

Hemimegalencephaly and intractable seizures associated with the NPRL3 gene variant in a newborn: A case report.

Ganglionic Eminence Anomalies and Coexisting Cerebral Developmental Anomalies on Fetal MR Imaging: Multicenter-Based Review of 60 Cases.

Phosphorylation of S6 Protein as a Potential Biomarker in Surgically Treated Refractory Epilepsy.

The Putative Role of mTOR Inhibitors in Non-tuberous Sclerosis Complex-Related Epilepsy.

Clinical experience with the AKT1 inhibitor miransertib in two children with PIK3CA-related overgrowth syndrome.

Neurite Outgrowth Inhibitor (NogoA) Is Upregulated in White Matter Lesions of Complex Cortical Malformations.

A new case of Smith-Kingsmore syndrome with somatic MTOR pathogenic variant expands the phenotypic spectrum to lateralized overgrowth.

Gradient of brain mosaic RHEB variants causes a continuum of cortical dysplasia.

Neuroimaging manifestations of epidermal nevus syndrome.

Hemimegalencephaly and tuberous sclerosis complex: A rare yet challenging association.

Delayed transhemispheric propagation of electrographic seizures following functional hemispherectomy.

Custom Pediatric Oncology Next-Generation Sequencing Panel Identifies Somatic Mosaicism in Archival Tissue and Enhances Targeted Clinical Care.

Failed Hemispherotomy: Insights from Our Early Experience in 40 Patients.

Neurocutaneous melanocytosis (melanosis).

Hemispherotomy for Epilepsy: The Procedure Evolution and Outcome.

Mosaic trisomy of chromosome 1q in human brain tissue associates with unilateral polymicrogyria, very early-onset focal epilepsy, and severe developmental delay.

Hemi-Hemimegalencephaly or Posterior Quadrantic Dysplasia, a Rare Cause of Focal Epilepsy in an Otherwise Healthy Young Woman: A Case Report.

Detailed analysis of phenotypes and genotypes in megalencephaly-capillary malformation-polymicrogyria syndrome caused by somatic mosaicism of PIK3CA mutations.

Structural MRI and tract-based spatial statistical analysis of diffusion tensor imaging in children with hemimegalencephaly.

Maternal mosaicism underlies the inheritance of a rare germline AKT3 variant which is responsible for megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome in two Roma half-siblings.

Posterior quadrant disconnection for sub-hemispheric drug refractory epilepsy.

Long-term outcomes after surgery for catastrophic epilepsy in infants: institutional experience and review of the literature.

mTOR pathway somatic variants and the molecular pathogenesis of hemimegalencephaly.

Measure thrice, cut twice: On the benefit of reoperation for failed pediatric epilepsy surgery.

Minimizing blood loss in hemispherectomy for hemimegalencephaly in low-weight infants: technical note.

Transient water-electrolyte disturbance after hemispherotomy in young infants with epileptic encephalopathy.

A journey through formation and malformations of the neo-cortex.

PI3K/mTOR Pathway Inhibition: Opportunities in Oncology and Rare Genetic Diseases.

GATORopathies: The role of amino acid regulatory gene mutations in epilepsy and cortical malformations.

Widespread frontal lobe cortical dysplasia or partial hemimegalencephaly: a continuum of the spectrum.

Imaging Findings of Klippel-Trenaunay Syndrome.

Prenatal diagnosis of hemimegalencephaly revealing tuberous sclerosis complex.

An infant with epilepsy: don't forget the importance of skin examination.

Dissecting the genetic basis of focal cortical dysplasia: a large cohort study.

Megalencephaly syndromes associated with mutations of core components of the PI3K-AKT-MTOR pathway: PIK3CA, PIK3R2, AKT3, and MTOR.

Somatic double-hit in MTOR and RPS6 in hemimegalencephaly with intractable epilepsy.

Case 2: Asymmetrical Frontal Bossing and Refractory Seizures in a Newborn.

Inclusion of hemimegalencephaly into the phenotypic spectrum of NPRL3 pathogenic variants in familial focal epilepsy with variable foci.

Late adult-onset epilepsy in a patient with hemimegalencephaly.

Physical Growth of the Contralateral Cerebrum is Preserved After Hemispherotomy in Childhood.

New insights into a spectrum of developmental malformations related to mTOR dysregulations: challenges and perspectives.

The Space-Time Continuum of Cortical Dysplasia.

Posterior quadrantic dysplasia with localized hemimegalencephaly in a patient with giant congenital melanocytic nevus: First case report.

Pathological mTOR mutations impact cortical development.

Outcome after hemispherotomy in patients with intractable epilepsy: Comparison of techniques in the Italian experience.

The role of somatic mutational events in the pathogenesis of epilepsy.

Evidence for Innate and Adaptive Immune Responses in a Cohort of Intractable Pediatric Epilepsy Surgery Patients.

Contribution of Altered Endocannabinoid System to Overactive mTORC1 Signaling in Focal Cortical Dysplasia.

Malformations of Cerebral Cortex Development: Molecules and Mechanisms.

Disrupted cortico-ponto-cerebellar pathway in patients with hemimegalencephaly.

Application of Automated Brain Segmentation and Fiber Tracking in Hemimegalencephaly.

mTOR Inhibitors as a New Therapeutic Strategy in Treatment Resistant Epilepsy in Hemimegalencephaly: A Case Report.

Endoscope-assisted (with robotic guidance and using a hybrid technique) interhemispheric transcallosal hemispherotomy: a comparative study with open hemispherotomy to evaluate efficacy, complications, and outcome.

Identification of a somatic mutation in the RHEB gene through high depth and ultra-high depth next generation sequencing in a patient with Hemimegalencephaly and drug resistant Epilepsy.

Oxidative stress and inflammation in a spectrum of epileptogenic cortical malformations: molecular insights into their interdependence.

Clinical pitfalls in the diagnosis of segmental overgrowth syndromes: a child with the c.2740G > A mutation in PIK3CA gene.

Brain Somatic Mutations in MTOR Disrupt Neuronal Ciliogenesis, Leading to Focal Cortical Dyslamination.

Posterior Quadrantic Dysplasia: MRI Diagnosis of a Lesser Known Cause of Pediatric Intractable Epilepsy.

Hemimegalencephaly: Seizure Outcome in an Infant after Hemispherectomy.

The 2016 Bernard Sachs Lecture: Timing in Morphogenesis and Genetic Gradients During Normal Development and in Malformations of the Nervous System.

Dysplastic megalencephaly phenotype presenting with prenatal high-output cardiac failure.

Complex observation of scalp fast (40-150 Hz) oscillations in West syndrome and related disorders with structural brain pathology.

Hemimyoclonus: A rare presentation of hemimegalencephaly.

Hemimegalencephaly with Bannayan-Riley-Ruvalcaba syndrome.

Review: Mechanistic target of rapamycin (mTOR) pathway, focal cortical dysplasia and epilepsy.

Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias.

Dysplasia and overgrowth: magnetic resonance imaging of pediatric brain abnormalities secondary to alterations in the mechanistic target of rapamycin pathway.

Targeting the Mammalian Target of Rapamycin for Epileptic Encephalopathies and Malformations of Cortical Development.

Periinsular anterior quadrantotomy: technical note.

Unusual Cause of West Syndrome.

The importance of prenatal 3-dimensional sonography in a case of a segmental overgrowth syndrome with unclear chromosomal microarray results.

Mutations of AKT3 are associated with a wide spectrum of developmental disorders including extreme megalencephaly.

Hemimegalencephaly with intractable epilepsy: A case report.

A Case of Epilepsia Partialis Continua Due to Linear Nevus Syndrome with Hemimegalencephaly.

mTOR mutations in Smith-Kingsmore syndrome: Four additional patients and a review.

Somatic uniparental disomy of Chromosome 16p in hemimegalencephaly.

What to do in failed hemispherotomy? Our clinical series and review of the literature.

Proteus Syndrome with Neurological Manifestations: A Rare Presentation.

Brain Inflammation in an Infant With Hemimegalencephaly, Escalating Seizures, and Epileptic Encephalopathy.

Differential roles for Akt and mTORC1 in the hypertrophy of Pten mutant neurons, a cellular model of brain overgrowth disorders.

Pathologic Active mTOR Mutation in Brain Malformation with Intractable Epilepsy Leads to Cell-Autonomous Migration Delay.

Electrophysiological Sequelae of Hemispherotomy in Ipsilateral Human Cortex.